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Aliases for DUSP16 Gene

Aliases for DUSP16 Gene

  • Dual Specificity Phosphatase 16 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 7 3 4
  • MAP Kinase Phosphatase 7 3 4
  • MAPK Phosphatase-7 2 3
  • MKP-7 3 4
  • MKP7 3 4
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • KIAA1700 4

External Ids for DUSP16 Gene

Previous GeneCards Identifiers for DUSP16 Gene

  • GC12M012354
  • GC12M012771
  • GC12M012527
  • GC12M012518
  • GC12M012520
  • GC12M012628

Summaries for DUSP16 Gene

Entrez Gene Summary for DUSP16 Gene

  • This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

GeneCards Summary for DUSP16 Gene

DUSP16 (Dual Specificity Phosphatase 16) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP16 Gene

  • Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.

Gene Wiki entry for DUSP16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP16 Gene

Genomics for DUSP16 Gene

Regulatory Elements for DUSP16 Gene

Promoters for DUSP16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP16 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP16 Gene

Chromosome:
12
Start:
12,473,282 bp from pter
End:
12,562,839 bp from pter
Size:
89,558 bases
Orientation:
Minus strand

Genomic View for DUSP16 Gene

Genes around DUSP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP16 Gene

Proteins for DUSP16 Gene

  • Protein details for DUSP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY84-DUS16_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 16
    Protein Accession:
    Q9BY84
    Secondary Accessions:
    • Q547C7
    • Q96QS2
    • Q9C0G3

    Protein attributes for DUSP16 Gene

    Size:
    665 amino acids
    Molecular mass:
    73102 Da
    Quaternary structure:
    • Interacts with ARRB2.
    SequenceCaution:
    • Sequence=BAB21791.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUSP16 Gene

    Alternative splice isoforms for DUSP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP16 Gene

Proteomics data for DUSP16 Gene at MOPED

Post-translational modifications for DUSP16 Gene

  • Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP16 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DUSP16 (MKP-7)

No data available for DME Specific Peptides for DUSP16 Gene

Domains & Families for DUSP16 Gene

Gene Families for DUSP16 Gene

Suggested Antigen Peptide Sequences for DUSP16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BY84

UniProtKB/Swiss-Prot:

DUS16_HUMAN :
  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP16: view

Function for DUSP16 Gene

Molecular function for DUSP16 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.

Enzyme Numbers (IUBMB) for DUSP16 Gene

Gene Ontology (GO) - Molecular Function for DUSP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0016791 phosphatase activity IEA --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP16: view
genes like me logo Genes that share phenotypes with DUSP16: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP16 Gene

Localization for DUSP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP16 Gene

Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP16 Gene COMPARTMENTS Subcellular localization image for DUSP16 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for DUSP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016023 cytoplasmic, membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with DUSP16: view

Pathways & Interactions for DUSP16 Gene

SuperPathways for DUSP16 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 MAPK signaling pathway
genes like me logo Genes that share pathways with DUSP16: view

Pathways by source for DUSP16 Gene

1 BioSystems pathway for DUSP16 Gene
1 KEGG pathway for DUSP16 Gene
1 Qiagen pathway for DUSP16 Gene

SIGNOR curated interactions for DUSP16 Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for DUSP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0045209 MAPK phosphatase export from nucleus, leptomycin B sensitive TAS 11489891
genes like me logo Genes that share ontologies with DUSP16: view

Drugs & Compounds for DUSP16 Gene

(1) Drugs for DUSP16 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(3) Additional Compounds for DUSP16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUSP16: view

Transcripts for DUSP16 Gene

Unigene Clusters for DUSP16 Gene

Dual specificity phosphatase 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP16 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3:
SP4: -

Relevant External Links for DUSP16 Gene

GeneLoc Exon Structure for
DUSP16
ECgene alternative splicing isoforms for
DUSP16

Expression for DUSP16 Gene

mRNA expression in normal human tissues for DUSP16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP16 Gene

This gene is overexpressed in Plasma (57.5) and Adrenal (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP16 Gene



SOURCE GeneReport for Unigene cluster for DUSP16 Gene Hs.536535

genes like me logo Genes that share expression patterns with DUSP16: view

Protein tissue co-expression partners for DUSP16 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUSP16 Gene

Orthologs for DUSP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUSP16 35
  • 82.91 (n)
  • 84.43 (a)
DUSP16 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP16 35
  • 91.29 (n)
  • 93.5 (a)
DUSP16 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp16 35
  • 88.64 (n)
  • 91.36 (a)
Dusp16 16
Dusp16 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUSP16 35
  • 99.45 (n)
  • 99.4 (a)
DUSP16 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp16 35
  • 88.08 (n)
  • 91.21 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP16 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP16 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP16 35
  • 78.69 (n)
  • 82.19 (a)
DUSP16 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP16 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp16 35
  • 68.22 (n)
  • 71.03 (a)
zebrafish
(Danio rerio)
Actinopterygii dusp16 35
  • 64.48 (n)
  • 65.92 (a)
dusp16 36
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vhp-1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for DUSP16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP16 Gene

ENSEMBL:
Gene Tree for DUSP16 (if available)
TreeFam:
Gene Tree for DUSP16 (if available)

Paralogs for DUSP16 Gene

Paralogs for DUSP16 Gene

(11) SIMAP similar genes for DUSP16 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DUSP16: view

Variants for DUSP16 Gene

Sequence variations from dbSNP and Humsavar for DUSP16 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs36049447 - 12,521,031(+) TTTCC(A/G)TTCCA reference, missense, utr-variant-5-prime
rs3809199 - 12,477,735(+) CTGCA(C/T)GCTGG reference, missense
rs16727 -- 12,474,391(+) TACAC(-/AT)GTCCT utr-variant-3-prime
rs736106 -- 12,474,475(+) GTAGA(A/C)GCGAG utr-variant-3-prime
rs736107 -- 12,474,476(+) TAGAC(A/G)CGAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DUSP16 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv898810 CNV Loss 21882294
dgv479e1 CNV Complex 17122850
nsv898811 CNV Gain 21882294
nsv523366 CNV Gain 19592680
esv33583 CNV Loss 17666407
nsv523022 CNV Loss 19592680
nsv8922 CNV Gain 18304495

Variation tolerance for DUSP16 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.60; 82.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP16 Gene

HapMap Linkage Disequilibrium report
DUSP16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP16 Gene

Disorders for DUSP16 Gene

Relevant External Links for DUSP16

Genetic Association Database (GAD)
DUSP16
Human Genome Epidemiology (HuGE) Navigator
DUSP16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP16

No disorders were found for DUSP16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP16 Gene

Publications for DUSP16 Gene

  1. MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein. (PMID: 11489891) Masuda K. … Kikuchi K. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. (PMID: 20122898) Masuda K. … Shima H. (Biochem. Biophys. Res. Commun. 2010) 3 23
  3. SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration. (PMID: 19307591) Pi X. … Patterson C. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  4. Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2. (PMID: 15888437) Willoughby E.A. … Collins M.K. (J. Biol. Chem. 2005) 2 3
  5. MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation. (PMID: 14586399) Hoornaert I. … Baens M. (Oncogene 2003) 3 23

Products for DUSP16 Gene

Sources for DUSP16 Gene

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