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Aliases for DUSP16 Gene

Aliases for DUSP16 Gene

  • Dual Specificity Phosphatase 16 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 7 3 4
  • MAP Kinase Phosphatase 7 3 4
  • MAPK Phosphatase-7 2 3
  • MKP-7 3 4
  • MKP7 3 4
  • Dual Specificity Protein Phosphatase 16 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • KIAA1700 4

External Ids for DUSP16 Gene

Previous GeneCards Identifiers for DUSP16 Gene

  • GC12M012354
  • GC12M012771
  • GC12M012527
  • GC12M012518
  • GC12M012520
  • GC12M012628

Summaries for DUSP16 Gene

Entrez Gene Summary for DUSP16 Gene

  • This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

GeneCards Summary for DUSP16 Gene

DUSP16 (Dual Specificity Phosphatase 16) is a Protein Coding gene. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP8.

UniProtKB/Swiss-Prot for DUSP16 Gene

  • Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.

Gene Wiki entry for DUSP16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP16 Gene

Genomics for DUSP16 Gene

Regulatory Elements for DUSP16 Gene

Enhancers for DUSP16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F012378 1.4 FANTOM5 Ensembl ENCODE 19.6 +182.5 182495 3.1 PKNOX1 MLX RAD21 RARA CREM MIXL1 TBX21 ZFP41 GLIS1 IKZF1 CDKN1B DUSP16 MANSC1 ENSG00000240424 BORCS5 APOLD1 BCL2L14 GC12M012376 GC12P012364
GH12F012439 1.2 FANTOM5 Ensembl ENCODE 18.2 +120.9 120861 5.9 HDGF PKNOX1 ARID4B YY1 SLC30A9 GATA2 FOS NFYC REST KAT8 BORCS5 DUSP16 DDX47 ENSG00000240424 CDKN1B CREBL2 APOLD1 BCL2L14 GPR19 GC12P012450
GH12F012508 1.3 FANTOM5 Ensembl ENCODE 17.4 +53.1 53103 2.7 CEBPB SIN3A ZNF121 JUND RAD51 FOS PRDM10 MAFK DUSP16 ENSG00000240424 CREBL2 BORCS5 DDX55P1 BCL2L14 PIR41199
GH12F012456 1.3 FANTOM5 Ensembl ENCODE 16.7 +105.7 105676 2.1 CTCF HLF MAFG ZBTB40 ZNF664 ZNF121 MAFF ZNF316 ZNF512 KLF9 DUSP16 ENSG00000240424 CREBL2 BORCS5 BCL2L14 ENSG00000271370 GC12P012465
GH12F012448 1.7 FANTOM5 Ensembl ENCODE 16.7 +112.6 112649 3.2 PKNOX1 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 NFYC MXD4 DUSP16 CREBL2 ENSG00000240424 ENSG00000255670 GPR19 BORCS5 BCL2L14 GC12P012450 GC12P012411
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DUSP16 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001461476 1639 4401 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 CBX5 ZNF263 SP3 SP5

Genomic Location for DUSP16 Gene

Chromosome:
12
Start:
12,473,282 bp from pter
End:
12,562,839 bp from pter
Size:
89,558 bases
Orientation:
Minus strand

Genomic View for DUSP16 Gene

Genes around DUSP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP16 Gene

Proteins for DUSP16 Gene

  • Protein details for DUSP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY84-DUS16_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 16
    Protein Accession:
    Q9BY84
    Secondary Accessions:
    • Q547C7
    • Q96QS2
    • Q9C0G3

    Protein attributes for DUSP16 Gene

    Size:
    665 amino acids
    Molecular mass:
    73102 Da
    Quaternary structure:
    • Interacts with ARRB2.
    SequenceCaution:
    • Sequence=BAB21791.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUSP16 Gene

    Alternative splice isoforms for DUSP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP16 Gene

Post-translational modifications for DUSP16 Gene

  • Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUSP16 Gene

Domains & Families for DUSP16 Gene

Gene Families for DUSP16 Gene

Suggested Antigen Peptide Sequences for DUSP16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BY84

UniProtKB/Swiss-Prot:

DUS16_HUMAN :
  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP16: view

Function for DUSP16 Gene

Molecular function for DUSP16 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.

Enzyme Numbers (IUBMB) for DUSP16 Gene

Gene Ontology (GO) - Molecular Function for DUSP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS 11489891
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IDA 24531476
genes like me logo Genes that share ontologies with DUSP16: view
genes like me logo Genes that share phenotypes with DUSP16: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP16 Gene

Localization for DUSP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP16 Gene

Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP16 Gene COMPARTMENTS Subcellular localization image for DUSP16 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for DUSP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 11489891
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 11489891
GO:0005829 cytosol IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with DUSP16: view

Pathways & Interactions for DUSP16 Gene

SuperPathways for DUSP16 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Immune System
5 Signaling by GPCR
genes like me logo Genes that share pathways with DUSP16: view

Pathways by source for DUSP16 Gene

1 Cell Signaling Technology pathway for DUSP16 Gene
1 BioSystems pathway for DUSP16 Gene
1 KEGG pathway for DUSP16 Gene
1 Qiagen pathway for DUSP16 Gene

SIGNOR curated interactions for DUSP16 Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for DUSP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 11489891
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation TAS 11489891
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0043409 negative regulation of MAPK cascade IEA --
genes like me logo Genes that share ontologies with DUSP16: view

Drugs & Compounds for DUSP16 Gene

(3) Drugs for DUSP16 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0

(1) Additional Compounds for DUSP16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with DUSP16: view

Transcripts for DUSP16 Gene

Unigene Clusters for DUSP16 Gene

Dual specificity phosphatase 16:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP16 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3:
SP4: -

Relevant External Links for DUSP16 Gene

GeneLoc Exon Structure for
DUSP16
ECgene alternative splicing isoforms for
DUSP16

Expression for DUSP16 Gene

mRNA expression in normal human tissues for DUSP16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP16 Gene

This gene is overexpressed in Plasma (57.5) and Adrenal (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUSP16 Gene



Protein tissue co-expression partners for DUSP16 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP16 Gene:

DUSP16

SOURCE GeneReport for Unigene cluster for DUSP16 Gene:

Hs.536535
genes like me logo Genes that share expression patterns with DUSP16: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUSP16 Gene

Orthologs for DUSP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP16 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia DUSP16 34 35
  • 91.29 (n)
mouse
(Mus musculus)
Mammalia Dusp16 34 16 35
  • 88.64 (n)
rat
(Rattus norvegicus)
Mammalia Dusp16 34
  • 88.08 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP16 35
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP16 34 35
  • 82.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP16 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP16 34 35
  • 78.69 (n)
lizard
(Anolis carolinensis)
Reptilia DUSP16 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp16 34
  • 68.22 (n)
zebrafish
(Danio rerio)
Actinopterygii dusp16 34 35
  • 64.48 (n)
worm
(Caenorhabditis elegans)
Secernentea vhp-1 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for DUSP16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP16 Gene

ENSEMBL:
Gene Tree for DUSP16 (if available)
TreeFam:
Gene Tree for DUSP16 (if available)

Paralogs for DUSP16 Gene

Paralogs for DUSP16 Gene

(11) SIMAP similar genes for DUSP16 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DUSP16: view

Variants for DUSP16 Gene

Sequence variations from dbSNP and Humsavar for DUSP16 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10538570 -- 12,532,659(+) TAAGA(-/AGA)TGAGA intron-variant
rs10555943 -- 12,495,237(+) ATTAC(-/A)AAAAA intron-variant
rs10685981 -- 12,541,828(+) AAATA(-/AACT)ATTTA intron-variant
rs10695021 -- 12,525,470(+) GTCAG(-/TCAG)GCTGG intron-variant
rs10743988 -- 12,501,692(+) TTTAA(C/T)ATTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP16 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV deletion 23290073
esv2759880 CNV gain 17122850
esv33583 CNV loss 17666407
esv3628615 CNV loss 21293372
esv3628616 CNV loss 21293372
nsv1046355 CNV loss 25217958
nsv1070096 CNV deletion 25765185
nsv1112617 CNV deletion 24896259
nsv1143559 CNV deletion 24896259
nsv523022 CNV loss 19592680
nsv523366 CNV gain 19592680
nsv8922 CNV gain 18304495

Variation tolerance for DUSP16 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.60; 82.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP16 Gene

Disorders for DUSP16 Gene

Relevant External Links for DUSP16

Genetic Association Database (GAD)
DUSP16
Human Genome Epidemiology (HuGE) Navigator
DUSP16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP16

No disorders were found for DUSP16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP16 Gene

Publications for DUSP16 Gene

  1. MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein. (PMID: 11489891) Masuda K. … Kikuchi K. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2. (PMID: 15888437) Willoughby E.A. … Collins M.K. (J. Biol. Chem. 2005) 2 3 4 64
  3. MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation. (PMID: 14586399) Hoornaert I. … Baens M. (Oncogene 2003) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. (PMID: 20122898) Masuda K. … Shima H. (Biochem. Biophys. Res. Commun. 2010) 3 22 64

Products for DUSP16 Gene

Sources for DUSP16 Gene

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