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DUSP16 Gene

protein-coding   GIFtS: 64
GCID: GC12M012628

Dual Specificity Phosphatase 16

  Search for DUSP16
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 161 2     MAP Kinase Phosphatase 72 3
MKP72 3 5     KIAA17003 5
MAPK Phosphatase-71 2     Dual Specificity Protein Phosphatase 162
Mitogen-Activated Protein Kinase Phosphatase 72 3     EC 3.1.3.163
MKP-72 3     EC 3.1.3.483

External Ids:    HGNC: 179091   Entrez Gene: 808242   Ensembl: ENSG000001112667   OMIM: 6071755   UniProtKB: Q9BY843   

Export aliases for DUSP16 gene to outside databases

Previous GC identifers: GC12M012354 GC12M012771 GC12M012527 GC12M012518 GC12M012520


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP16 Gene:
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein
phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun
amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.(provided by RefSeq, May
2010)

GeneCards Summary for DUSP16 Gene:
DUSP16 (dual specificity phosphatase 16) is a protein-coding gene. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS16_HUMAN, Q9BY84
Function: Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates
MAPK10 bound to ARRB2

Gene Wiki entry for DUSP16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP16 gene promoter:
         COUP-TF1   AP-1   ATF-2   COUP   HNF-4alpha1   POU2F1   COUP-TF   HOXA5   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DUSP16 promoter sequence
   Search Chromatin IP Primers for DUSP16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

DUSP16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP16 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M012628:  view genomic region     (about GC identifiers)

Start:
12,626,216 bp from pter      End:
12,715,448 bp from pter
Size:
89,233 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DUS16_HUMAN, Q9BY84 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 16  
Size: 665 amino acids; 73102 Da
Subunit: Interacts with ARRB2
Sequence caution: Sequence=BAB21791.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for DUSP16:
2VSW (3D)        3TG3 (3D)    
Secondary accessions: Q547C7 Q9C0G3

Explore the universe of human proteins at neXtProt for DUSP16: NX_Q9BY84

Explore proteomics data for DUSP16 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK
    MAPK activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DUSP16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_085143.1  
    ENSEMBL proteins: 
     ENSP00000228862   ENSP00000443039   ENSP00000441250   ENSP00000298573  

    DUSP16 Human Recombinant Protein Products:

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    Novus Biologicals DUSP16 Protein
    Novus Biologicals DUSP16 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DUSP16

     
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    DUSP16 Assay Products:

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    Search eBioscience for ELISAs for DUSP16 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    Selected InterPro protein domains (see all 7):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q9BY84

    ProtoNet protein and cluster: Q9BY84

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS16_HUMAN, Q9BY84
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with DUSP16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS16_HUMAN, Q9BY84
    Function: Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates
    MAPK10 bound to ARRB2
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS11489891
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with DUSP16           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DUSP16:
     Synthetic lethal with Ras  Upregulation of NF-kappaB path 

         1 MGI phenotypic allele for Dusp16 (no phenotypes)

    Find genes that share phenotypes with DUSP16           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DUSP16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP16

    miRNA
    Products:
        
    miRTarBase miRNAs that target DUSP16:
    hsa-mir-192-5p (MIRT026190), hsa-mir-335-5p (MIRT016920)

    Block miRNA regulation of human, mouse, rat DUSP16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DUSP16 (see all 67):
    hsa-miR-140-5p hsa-miR-1321 hsa-miR-640 hsa-miR-1260b hsa-miR-938 hsa-miR-342-3p hsa-miR-10b* hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidDUSP16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DUSP16
    Predesigned siRNA for gene silencing in human, mouse, rat DUSP16

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector: DUSP16 (NM_030640)
    Sino Biological Human cDNA Clone for DUSP16
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP16
    Addgene plasmids for DUSP16 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DUSP16 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS16_HUMAN, Q9BY84: Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation,
    re-associates with ARRB2 on endocytic vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS11489891
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS11489891
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    Find genes that share ontologies with DUSP16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DUSP16 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1TGF-Beta Pathway
    JNK Pathway0.51
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    3MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31
    4Transcription P53 signaling pathway
    Transcription P53 signaling pathway
    5Signal transduction Erk Interactions Inhibition of Erk
    Signal transduction Erk Interactions Inhibition of Erk


    Find genes that share SuperPaths with DUSP16           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DUSP16
        JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for DUSP16
        Phosphatases
    MAP Kinase Signaling

    2 GeneGo (Thomson Reuters) Pathways for DUSP16
        Signal transduction Erk Interactions- Inhibition of Erk
    Transcription P53 signaling pathway

    1 BioSystems Pathway for DUSP16
        Regulation of p38-alpha and p38-beta



    1 Kegg Pathway  (Kegg details for DUSP16):
        MAPK signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP16: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DUSP16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for DUSP16 (Q9BY843 ENSP000002288624) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284823, ENSP000002158324I2D: score=3 STRING: ENSP00000215832
    MAPK8IP1Q9UQF23, ENSP000002410144I2D: score=3 STRING: ENSP00000241014
    MAPK9P459843, ENSP000003214104I2D: score=3 STRING: ENSP00000321410
    MAPK10P537793, ENSP000003521574I2D: score=2 STRING: ENSP00000352157
    MAPK8IP2Q133873, ENSP000003305724I2D: score=2 STRING: ENSP00000330572
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity TAS11489891
    GO:0006470protein dephosphorylation IBA--
    GO:0016311dephosphorylation TAS11489891
    GO:0043409negative regulation of MAPK cascade ----
    GO:0045204MAPK export from nucleus TAS11489891

    Find genes that share ontologies with DUSP16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP16 (DUS16)

    3 HMDB Compounds for DUSP16    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DUSP16 gene: 
    NM_030640.2  

    Unigene Cluster for DUSP16:

    Dual specificity phosphatase 16
    Hs.536535  [show with all ESTs]
    Unigene Representative Sequence: NM_030640
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228862(uc001ran.2 uc001rao.2) ENST00000545864 ENST00000539940
    ENST00000541207 ENST00000536236 ENST00000298573
    miRNA
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    Block miRNA regulation of human, mouse, rat DUSP16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DUSP16 (see all 67):
    hsa-miR-140-5p hsa-miR-1321 hsa-miR-640 hsa-miR-1260b hsa-miR-938 hsa-miR-342-3p hsa-miR-10b* hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidDUSP16 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DUSP16
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DUSP16 (NM_030640)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP16
    Addgene plasmids for DUSP16 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DUSP16
      QuantiFast Probe-based Assays in human, mouse, rat DUSP16

    Additional mRNA sequence: 

    AB051487.1 AB052156.1 AF506796.1 AK022103.1 AK055973.1 AK093617.1 AK097936.1 AK098310.1 
    AL137633.1 AL833073.2 AY038927.1 BC031643.1 BC042101.1 BC109234.1 BC109235.1 

    8 DOTS entries:

    DT.442185  DT.97779061  DT.100819736  DT.97807742  DT.91752317  DT.75193717  DT.424720  DT.95309666 

    Selected AceView cDNA sequences (see all 187):

    AI637845 AL833073 T23935 BI816954 AA159408 AA372871 AA350994 CB133347 
    CA944683 AY038927 CB158240 BQ670989 AI659120 R56208 AW014773 AF506796 
    AW028027 AA081569 BM906608 BC031643 BF725331 BM684162 AI654997 BM826936 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP16    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:        -     -     -                                                         
    SP2:                                                        -                     
    SP3:                                                                              
    SP4:                    -                                                         


    ECgene alternative splicing isoforms for DUSP16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUSP16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTTAATG
    DUSP16 Expression
    About this image


    DUSP16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Lung (Respiratory System)
             Trachea
     
     Kidney (Urinary System)
             Metanephros
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
    DUSP16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.536535
        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP16: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP16
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    QuantiFast Probe-based Assays in human, mouse, rat DUSP16
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DUSP16 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp161 , 5 dual specificity phosphatase 161, 5 88.64(n)1
    91.36(a)1
      6 (65.77 cM)5
    706861  NM_130447.31  NP_569714.21 
     1347154735 
    chicken
    (Gallus gallus)
    Aves DUSP161 dual specificity phosphatase 16 78.69(n)
    82.19(a)
      431336  XM_428887.4  XP_428887.3 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP166
    dual specificity phosphatase 16
    76(a)
    1 ↔ 1
    5(82959500-83009005)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dusp161 dual specificity phosphatase 16 68.22(n)
    71.03(a)
      100036691  NM_001097242.1  NP_001090711.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dusp161 dual specificity phosphatase 16 64.48(n)
    65.92(a)
      406523  NM_213240.1  NP_998405.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vhp-16
    Protein VHP-1, isoform a
    27(a)
    1 → many
    II(5323007-5340818) WBGene00006923


    ENSEMBL Gene Tree for DUSP16 (if available)
    TreeFam Gene Tree for DUSP16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for DUSP16 gene
    DUSP42  SSH22  DUSP52  DUSP102  DUSP62  SSH32  DUSP92  DUSP22  
    DUSP82  DUSP12  DUSP72  SSH12  
    11 SIMAP similar genes for DUSP16 using alignment to 4 protein entries:     DUS16_HUMAN (see all proteins):
    MKP7    DUSP8    DUSP21    DUSP22    DUSP13    DUSP6
    DUSP3    DUSP14    DUSP18    DUSP2    DUSP4

    Find genes that share paralogs with DUSP16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP16 (see all 1913)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38399781,2
    C--12397463(+) AAAAA-/A/AC  
            
    CTTGG
    1 -- int11NA 2
    rs1830071351,2
    --12404670(+) TGTGTC/GTGTGT 1 -- int10--------
    rs2007846391,2
    C--12405526(+) TAAAG-/AAAAAA 1 -- int10--------
    rs1123439361,2
    C--12406424(+) CCTACTTTG/-  
            
    CTTTA
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1502465721,2
    C--12406425(+) CTACT-/TTTG  
            
    TTAAC
    1 -- int10--------
    rs2001317281,2
    C--12406427(+) ACTTT-/GTTT  
            
    AACCT
    1 -- int10--------
    rs352682751,2
    C--12407829(+) CAATC-/AAAAGA 1 -- int10--------
    rs1410065421,2
    C--12408579(+) AAAAC-/AAAAAA 1 -- int10--------
    rs764889691,2
    C,F--12408587(+) AAAAAA/CCCCTT 1 -- int12Minor allele frequency- C:0.16NA EA 240
    rs1394299671,2
    C--12427514(+) CAAAA-/TTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for DUSP16 (12626216 - 12715448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DUSP16:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745567CNV Deletion23290073
    esv33583CNV Loss17666407
    nsv898810CNV Loss21882294
    nsv523022CNV Loss19592680
    nsv523366CNV Gain19592680
    nsv8922CNV Gain18304495
    nsv898811CNV Gain21882294
    dgv479e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607175    OMIM disorders: --


    Find genes that share disorders with DUSP16           About GenesLikeMe

    Genetic Association Database (GAD): DUSP16
    Human Genome Epidemiology (HuGE) Navigator: DUSP16 (1 document)

    Export disorders for DUSP16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP16 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with DUSP16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein. (PubMed id 11489891)1, 2, 3, 9 Masuda K.... Kikuchi K. (J. Biol. Chem. 2001)
    2. Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2. (PubMed id 15888437)1, 2, 3 Willoughby E.A. and Collins M.K. (J. Biol. Chem. 2005)
    3. MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation. (PubMed id 14586399)1, 2, 9 Hoornaert I.... Baens M. (Oncogene 2003)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446. (PubMed id 12794087)1, 2 Masuda K.... Kikuchi K. (J. Biol. Chem. 2003)
    7. A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. (PubMed id 11359773)1, 3 Tanoue T.... Nishida E. (J. Biol. Chem. 2001)
    8. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    9. MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. (PubMed id 20122898)1, 9 Masuda K....Shima H. (Biochem. Biophys. Res. Commun. 2010)
    10. SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration. (PubMed id 19307591)1, 9 Pi X....Patterson C. (Proc. Natl. Acad. Sci. U.S.A. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80824 HGNC: 17909 AceView: DUSP16 Ensembl:ENSG00000111266 euGenes: HUgn80824
    ECgene: DUSP16 Kegg: 80824 H-InvDB: DUSP16

    (According to HUGE)
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    HUGE: KIAA1700

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUSP16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DUSP16 gene:
    Search GeneIP for patents involving DUSP16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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