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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP15 Gene

protein-coding   GIFtS: 50
GCID: GC20M030439

dual specificity phosphatase 15

(Previous name: dual specificity phosphatase-like 15 )
 Explore 2 diseases affiliated with
DUSP15 via our new
 Human Malady Compendium 
Biological research products
for DUSP15
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 151 2     BA243J16.61
VHY1 2 3     Dual Specificity Protein Phosphatase 152
Dual Specificity Phosphatase-Like 151 2     C20orf573
Vaccinia Virus VH1-Related Dual-Specific Protein Phosphatase Y2 3     EC 3.1.3.163
VH1-Related Member Y2 3     EC 3.1.3.483

External Ids:    HGNC: 162361   Entrez Gene: 1288532   Ensembl: ENSG000001495997   UniProtKB: Q9H1R23   

Export aliases for DUSP15 gene to outside databases

Previous GC identifers: GC20M030237 GC20M030183 GC20M031133 GC20M031180 GC20M031181 GC20M029899 GC20M029912 GC20M030437


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP15:
The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The
encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and
therefore is known as a dual specificity phosphatase. Three transcript variants encoding two different isoforms have
been found for this gene. (provided by RefSeq, Jul 2008)

Gene Wiki entry for DUSP15


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP15 gene promoter:
         AREB6   Nkx2-5   POU3F2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP15 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

DUSP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP15 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M030439:  view genomic region     (about GC identifiers)

Start:
30,435,440 bp from pter      End:
30,458,550 bp from pter
Size:
23,111 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 15  
Size: 295 amino acids; 31882 Da
Subcellular location: Cytoplasm (Probable)
Subcellular location: Isoform 3: Cell membrane; Lipid-anchor; Cytoplasmic side
Caution: Although assigned as two separate genes (c20orf57 and DUSP15), it is probable that C20orf57 does not exist by
itself and is a part of the DUSP15 gene
1 PDB 3D structure from and Proteopedia for DUSP15:
1YZ4 (3D)    
Secondary accessions: A6NH79 A8MVC8 Q5QP62 Q5QP63 Q5QP65 Q6PGN7 Q8N826 Q9BX24
Alternative splicing: 4 isoforms:  Q9H1R2-1   Q9H1R2-2   Q9H1R2-3   Q9H1R2-4   (Initiator Met-1 is removed. Myristoylated on Gly-2)

Explore the universe of human proteins at neXtProt for DUSP15: NX_Q9H1R2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H1R2

  • DUSP15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001012662.1  NP_542178.2  NP_817130.1  

    ENSEMBL proteins: 
     ENSP00000278979   ENSP00000397486   ENSP00000381158   ENSP00000341658   ENSP00000419818  
     ENSP00000365133   ENSP00000390355   ENSP00000381157  

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    Uscn Proteins for DUSP15

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--


    DUSP15 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DUSP15 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR000387 Tyr/Dual-sp_Pase
     IPR008984 SMAD_FHA_domain
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR017855 SMAD_dom-like
     IPR016130 Tyr_Pase_AS

    Graphical View of Domain Structure for InterPro Entry Q9H1R2

    ProtoNet protein and cluster: Q9H1R2

    1 Blocks protein family: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

    Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

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    hsa-miR-3910 hsa-miR-647 hsa-miR-103a hsa-miR-361-3p hsa-miR-214 hsa-miR-1184 hsa-miR-124 hsa-miR-593*
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI17474147
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--


    DUSP15 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUSP15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for DUSP15 (Q9H1R21, 2, 3 ENSP000003416584) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191741, 2, 3, ENSP000002440074EBI-1752795,EBI-79387 MINT-8112495 I2D: score=3 STRING: ENSP00000244007
    ABL1P005192, 3, ENSP000003614234MINT-8110287 I2D: score=3 STRING: ENSP00000361423
    PIK3R1P279862, 3, ENSP000002743354MINT-8111907 I2D: score=3 STRING: ENSP00000274335
    NCK1P163331, 3, ENSP000002889864EBI-1752795,EBI-3448658 I2D: score=2 STRING: ENSP00000288986
    SRCP129312, 3, ENSP000003509414MINT-8113071 I2D: score=3 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IBA--


    DUSP15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP15

    3 HMDB Compounds for DUSP15    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about DUSP15 / DUS15 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DUSP15 gene (3 alternative transcripts): 
    NM_001012644.1  NM_080611.3  NM_177991.1  

    Unigene Cluster for DUSP15:

    Dual specificity phosphatase 15
    Hs.585017  [show with all ESTs]
    Unigene Representative Sequence: AK091960
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278979(uc002wwu.1) ENST00000447647 ENST00000398084(uc002www.1)
    ENST00000339738(uc002wwx.1) ENST00000486996 ENST00000375966 ENST00000459848
    ENST00000493115 ENST00000428829 ENST00000398083(uc002wwv.1)

    miRNA
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    Additional cDNA sequence: 

    AK091960.1 BC056911.1 

    6 DOTS entries:

    DT.95270086  DT.443790  DT.95270085  DT.100741390  DT.97792550  DT.99930631 

    24/48 AceView cDNA sequences (see all 48):

    NM_177991 AW338231 BX280906 CR617339 AK000652 AI024644 BX114315 AW137822 
    NM_080611 BI826770 AK091960 BF732835 BC056911 BM554314 BV187109 BI831210 
    AI051640 AA938628 BI829823 AW406620 BI757411 AW593296 AI243454 AI208538 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP15    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                          -           -           -                           
    SP2:                          -           -                                       
    SP3:                                                                              


    ECgene alternative splicing isoforms for DUSP15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTCACCCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    DUSP15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyGlomerulusKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DUSP15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP15

    SOURCE GeneReport for Unigene cluster: Hs.585017

    UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2
    Tissue specificity: Highly expressed in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUSP15 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DUSP151 dual specificity phosphatase 15 69.63(n)
    71.03(a)
      419277  XM_417451.2  XP_417451.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100896
    --
    20(a)
    1 → many
    3L(13458909-13467643)
    worm
    (Caenorhabditis elegans)
    Secernentea C16A3.26
    Protein C16A3.2
    20(a)
    possible ortholog
    III(6389780-6390785)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MKP26
    DSPTP16
    dual specificity protein phosphatase 1
    31(a)
    22(a)
    many ↔ many
    many ↔ many
    3(1843413-1845014)
    3(8478122-8479857)
    rice
    (Oryza sativa)
    Liliopsida --
    dual specificity protein phosphatase, putative, ex...
    29(a)
    1 → many
    1(16510500-16517634)


    ENSEMBL Gene Tree for DUSP15 (if available)
    TreeFam Gene Tree for DUSP15 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP15 gene
    DUSP222  DUSP122  STYX2  
    4 SIMAP similar genes for DUSP15 using alignment to 3 protein entries:     DUS15_HUMAN (see all proteins):
    DUSP22    DUSP19    DUSP18    DUSP21

    DUSP15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/178 NCBI SNPs in DUSP15 are shown (see all 178    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432627301,2
    --30448403(+) TCTGG-/CTGTGT 3 -- ds50010--------
    rs793190471,2
    --30448465(+) ATTAAG/ATGAAC 3 -- ds50012Minor allele frequency- A:0.06NA EA 122
    rs1426182811,2
    --30448532(+) TTGTGA/CACAGG 3 -- ds50010--------
    rs49115351,2
    C,F,A,--30448565(+) GGAGGG/AGCCCC 3 -- ds5001 trp32Minor allele frequency- A:0.15NA EA 240
    rs1846431601,2
    --30448606(+) GAAGGG/TGGTTC 3 -- ds50010--------
    rs1468467241,2
    --30449043(+) TGGGGA/GCGCTG 3 -- ut310--------
    rs125691,2
    C,F,H,--30449181(-) CTCCCC/TACTTC 3 -- ut31 ese313Minor allele frequency- T:0.10EA NS NA WA EU 1881
    rs1135057271,2
    C,F,--30449183(+) AGTGGA/C/GGAGCC 6 -- ut312CSA EU 251
    rs2004746171,2
    C,--30449234(+) GACACC/TGGGGG 6 Q R mis10--------
    rs9473101,2
    C,F,A,H,--30449325(+) CTGCAC/GGGTTC 6 L V mis110Minor allele frequency- G:0.43NS EA NA WA CSA 661

    HapMap Linkage Disequilibrium report for DUSP15 (30435440 - 30458550 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DUSP15: --
    Human Gene Mutation Database (HGMD): DUSP15

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for DUSP15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DUSP15 for disorders           About GeneDecksing

    2 diseases for DUSP15:    About MalaCards
    vaccinia    malaria


    Export disorders for DUSP15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP15 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with DUSP15)
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    1. VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. (PubMed id 15138252)1, 2, 3 Alonso A.... Mustelin T. (2004)
    2. Crystal structure of the catalytic domain of human VHY, a dual- specificity protein phosphatase. (PubMed id 16170801)1, 2 Yoon T.-S.... Kim S.J. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 128853 HGNC: 16236 AceView: DUSP15 Ensembl:ENSG00000149599 euGenes: HUgn128853
    ECgene: DUSP15 H-InvDB: DUSP15

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DUSP15 gene:
    Search GeneIP for patents involving DUSP15

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