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Aliases for DUSP15 Gene

Aliases for DUSP15 Gene

  • Dual Specificity Phosphatase 15 2 3 5
  • Vaccinia Virus VH1-Related Dual-Specific Protein Phosphatase Y 3 4
  • Dual Specificity Phosphatase-Like 15 2 3
  • VH1-Related Member Y 3 4
  • C20orf57 3 4
  • VHY 3 4
  • Chromosome 20 Open Reading Frame 57 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP15 Gene

Previous HGNC Symbols for DUSP15 Gene

  • C20orf57

Previous GeneCards Identifiers for DUSP15 Gene

  • GC20M030237
  • GC20M030183
  • GC20M031133
  • GC20M031180
  • GC20M031181
  • GC20M029899
  • GC20M029912
  • GC20M030437
  • GC20M030439
  • GC20M030443
  • GC20M030446

Summaries for DUSP15 Gene

Entrez Gene Summary for DUSP15 Gene

  • The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for DUSP15 Gene

DUSP15 (Dual Specificity Phosphatase 15) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP21.

Gene Wiki entry for DUSP15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP15 Gene

Genomics for DUSP15 Gene

Regulatory Elements for DUSP15 Gene

Promoters for DUSP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP15 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP15 Gene

Chromosome:
20
Start:
31,847,637 bp from pter
End:
31,870,747 bp from pter
Size:
23,111 bases
Orientation:
Minus strand

Genomic View for DUSP15 Gene

Genes around DUSP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP15 Gene

Proteins for DUSP15 Gene

  • Protein details for DUSP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1R2-DUS15_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 15
    Protein Accession:
    Q9H1R2
    Secondary Accessions:
    • A6NH79
    • A8MVC8
    • Q5QP62
    • Q5QP63
    • Q5QP65
    • Q6PGN7
    • Q8N826
    • Q9BX24

    Protein attributes for DUSP15 Gene

    Size:
    295 amino acids
    Molecular mass:
    31882 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP15 Gene

    Alternative splice isoforms for DUSP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP15 Gene

Proteomics data for DUSP15 Gene at MOPED

Post-translational modifications for DUSP15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DUSP15 Gene

Domains & Families for DUSP15 Gene

Gene Families for DUSP15 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1R2

UniProtKB/Swiss-Prot:

DUS15_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP15: view

Function for DUSP15 Gene

Molecular function for DUSP15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for DUSP15 Gene

Gene Ontology (GO) - Molecular Function for DUSP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP15: view
genes like me logo Genes that share phenotypes with DUSP15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP15

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUSP15 Gene

Localization for DUSP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP15 Gene

Cytoplasm.
Isoform 3: Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP15 Gene COMPARTMENTS Subcellular localization image for DUSP15 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DUSP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DUSP15: view

Pathways & Interactions for DUSP15 Gene

SuperPathways for DUSP15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway IBA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0042127 regulation of cell proliferation IBA --
genes like me logo Genes that share ontologies with DUSP15: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP15 Gene

Drugs & Compounds for DUSP15 Gene

(1) Drugs for DUSP15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(3) Additional Compounds for DUSP15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUSP15: view

Transcripts for DUSP15 Gene

Unigene Clusters for DUSP15 Gene

Dual specificity phosphatase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3:

Relevant External Links for DUSP15 Gene

GeneLoc Exon Structure for
DUSP15
ECgene alternative splicing isoforms for
DUSP15

Expression for DUSP15 Gene

mRNA expression in normal human tissues for DUSP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP15 Gene

This gene is overexpressed in Testis (x19.6) and Kidney - Cortex (x7.2).

Protein differential expression in normal tissues from HIPED for DUSP15 Gene

This gene is overexpressed in Spinal cord (37.8) and Frontal cortex (30.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP15 Gene



SOURCE GeneReport for Unigene cluster for DUSP15 Gene Hs.585017

mRNA Expression by UniProt/SwissProt for DUSP15 Gene

Q9H1R2-DUS15_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with DUSP15: view

Protein tissue co-expression partners for DUSP15 Gene

Primer Products

In Situ Assay Products

Orthologs for DUSP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUSP15 35
  • 91.49 (n)
  • 93.19 (a)
DUSP15 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP15 35
  • 92.48 (n)
  • 94.47 (a)
DUSP15 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp15 35
  • 87.09 (n)
  • 88.94 (a)
Dusp15 16
Dusp15 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUSP15 35
  • 99.01 (n)
  • 98.3 (a)
DUSP15 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp15 35
  • 86.95 (n)
  • 88.94 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP15 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP15 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP15 35
  • 69.63 (n)
  • 71.03 (a)
DUSP15 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP15 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dusp22a 36
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10089 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C16A3.2 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9033 36
  • 37 (a)
OneToMany
Species with no ortholog for DUSP15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DUSP15 Gene

ENSEMBL:
Gene Tree for DUSP15 (if available)
TreeFam:
Gene Tree for DUSP15 (if available)

Paralogs for DUSP15 Gene

(4) SIMAP similar genes for DUSP15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DUSP15: view

Variants for DUSP15 Gene

Sequence variations from dbSNP and Humsavar for DUSP15 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs12569 -- 31,861,378(-) CTCCC(A/C/G/T)ACTTC utr-variant-3-prime
rs947310 -- 31,861,522(+) CTGCA(C/G)GGTTC reference, missense
rs947311 -- 31,864,289(+) ATGGG(A/T)GGGAG intron-variant
rs2377318 -- 31,865,231(+) TCAGC(A/G)GCGTG intron-variant
rs2889598 -- 31,865,619(+) AATGG(A/C)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP15 Gene

Variant ID Type Subtype PubMed ID
nsv833952 CNV Gain 17160897
nsv912836 CNV Loss 21882294

Variation tolerance for DUSP15 Gene

Gene Damage Index Score: 3.52; 55.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP15 Gene

HapMap Linkage Disequilibrium report
DUSP15
Human Gene Mutation Database (HGMD)
DUSP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP15 Gene

Disorders for DUSP15 Gene

Relevant External Links for DUSP15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP15

No disorders were found for DUSP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP15 Gene

Publications for DUSP15 Gene

  1. VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. (PMID: 15138252) Alonso A. … Mustelin T. (J. Biol. Chem. 2004) 2 3 4 67
  2. Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach. (PMID: 22792334) Schmidt F. … Hooft van Huijsduijnen R. (PLoS ONE 2012) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3

Products for DUSP15 Gene

Sources for DUSP15 Gene

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