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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP14 Gene

protein-coding   GIFtS: 58
GCID: GC17P035850

Dual Specificity Phosphatase 14

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 141 2     MAP Kinase Phosphatase 62 3
MKP62 3 5     MKP-1-Like Protein Tyrosine Phosphatase2 3
MKP-1 Like Protein Tyrosine Phosphatase1 2     Dual Specificity Protein Phosphatase 142
Mitogen-Activated Protein Kinase Phosphatase 62 3     EC 3.1.3.163
MKP-62 3     EC 3.1.3.483
MKP-L2 3     

External Ids:    HGNC: 170071   Entrez Gene: 110722   Ensembl: ENSG000001613267   OMIM: 6066185   UniProtKB: O951473   

Export aliases for DUSP14 gene to outside databases

Previous GC identifers: GC17P035255 GC17P037802 GC17P035580 GC17P036045 GC17P032924 GC17P031787


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP14 Gene:
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based
protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both
tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling
pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain
found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by
Patterson et al., 2009 (PubMed 19228121)).(supplied by OMIM, Dec 2009)

GeneCards Summary for DUSP14 Gene: 
DUSP14 (dual specificity phosphatase 14) is a protein-coding gene. Diseases associated with DUSP14 include ataxia telangiectasia, and ataxia, and among its related super-pathways are MAPK Family Pathway and MAPK signaling pathway. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS14_HUMAN, O95147
Function: Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP14 gene promoter:
         FOXF2   CUTL1   POU3F2   E47   PPAR-gamma1   FOXO4   Hand1   IRF-7A   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP14 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

DUSP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP14 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P035850:  view genomic region     (about GC identifiers)

Start:
35,849,937 bp from pter      End:
35,873,603 bp from pter
Size:
23,667 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DUS14_HUMAN, O95147 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 14  
Size: 198 amino acids; 22255 Da
Subunit: Interacts with CD28
1 PDB 3D structure from and Proteopedia for DUSP14:
2WGP (3D)    

Explore the universe of human proteins at neXtProt for DUSP14: NX_O95147

Explore proteomics data for DUSP14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95147

  • DUSP14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DUSP14 Protein Expression
    REFSEQ proteins: NP_008957.1  
    ENSEMBL proteins: 
     ENSP00000377912   ENSP00000377910   ENSP00000466299  

    Human Recombinant Protein Products for DUSP14: 
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    OriGene MassSpec for DUSP14 
    OriGene Custom Protein Services for DUSP14
    GenScript Custom Purified and Recombinant Proteins Services for DUSP14
    Novus Biologicals DUSP14 Protein
    Novus Biologicals DUSP14 Lysates
    Sino Biological Recombinant Protein for DUSP14
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DUSP14 


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    LSBio Antibodies in human, mouse, rat for DUSP14 

    Assay Products for DUSP14: 
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    Cloud-Clone Corp. ELISAs for DUSP14 
    Cloud-Clone Corp. CLIAs for DUSP14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

    5/7 InterPro protein domains (see all 7):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR020417 Atypical_DUSP
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry O95147

    ProtoNet protein and cluster: O95147

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: DUS14_HUMAN, O95147
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    DUSP14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS14_HUMAN, O95147
    Function: Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
    GO:0016791phosphatase activity ----
    GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IEA--
         
    DUSP14 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DUSP14:
     Decreased focal adhesion (FA)   Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DUSP14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DUSP14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP14 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP14
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP14:
    hsa-miR-548g hsa-miR-3908 hsa-miR-586 hsa-miR-3662 hsa-miR-548c-3p hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidDUSP14 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DUSP14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP14

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DUSP14

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP14
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                         Customized lentivirus expression plasmids for stable overexpression of DUSP14 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DUSP14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TGF-Beta Pathway
    JNK Pathway0.51
    2MAPK signaling pathway
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DUSP14
        JNK Pathway



    1         Kegg Pathway  (Kegg details for DUSP14):
        MAPK signaling pathway


    DUSP14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP14

    2 Interacting proteins for DUSP14 (O951473) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD28P107473I2D: score=2 
    UCHL5Q9Y5K53I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation IBA--

    DUSP14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP14 (DUS14)

    3 HMDB Compounds for DUSP14    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about DUSP14 / DUS14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DUSP14 gene: 
    NM_007026.2  

    Unigene Cluster for DUSP14:

    Dual specificity phosphatase 14
    Hs.91448  [show with all ESTs]
    Unigene Representative Sequence: AK027210
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394389(uc002hnx.2) ENST00000394386 ENST00000487847(uc002hnz.2)

    miRNA
    Products:
         
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP14:
    hsa-miR-548g hsa-miR-3908 hsa-miR-586 hsa-miR-3662 hsa-miR-548c-3p hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidDUSP14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DUSP14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP14
    Clone
    Products:
         
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    OriGene ORF clones in mouse, rat for DUSP14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DUSP14 (NM_007026)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP14
    Sirion Biotech Customized lentivirus for stable overexpression of DUSP14 
                         Customized lentivirus expression plasmids for stable overexpression of DUSP14 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DUSP14
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP14

    Additional mRNA sequence: 

    AF038844.1 AF120032.1 AK027210.1 AK314894.1 BC000370.2 BC001894.1 BC004448.1 CR536500.1 
    CR541800.1 

    11 DOTS entries:

    DT.75134105  DT.120987456  DT.92434921  DT.40261958  DT.100783372  DT.95125000  DT.100698286  DT.100783376 
    DT.40118316  DT.92434925  DT.92434923 

    24/183 AceView cDNA sequences (see all 183):

    AL527826 CR604963 CR623161 BF219817 CR617844 BU165903 BM709347 BG113495 
    AA297955 CR599138 CR541800 CR608141 CR536500 AA126103 AL556366 AA595226 
    CR623231 BQ898275 AW261913 CR595784 AA744940 AL556367 BE673302 CR603252 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP14 expression in normal human tissues (normalized intensities)      DUSP14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCCAGGAT
    DUSP14 Expression
    About this image


    DUSP14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Adrenal Gland (Endocrine System)

    See DUSP14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP14

    SOURCE GeneReport for Unigene cluster: Hs.91448
        SABiosciences Expression via Pathway-Focused PCR Arrays including DUSP14: 
              Insulin Signaling Pathway in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Protein Phosphatases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DUSP14 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp141 , 5 dual specificity phosphatase 141, 5 90.74(n)1
    93.94(a)1
      11 (51.29 cM)5
    564051  NM_019819.31  NP_062793.21 
     840480415 
    chicken
    (Gallus gallus)
    Aves DUSP141 dual specificity phosphatase 14 79.63(n)
    85.35(a)
      417657  XM_415902.3  XP_415902.2 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP146
    --
    Uncharacterized protein
    72(a)
    62(a)
    1 ↔ 1
    possible ortholog
    GL343439.1(29412-30011)
    GL343606.1(348060-348632)
    zebrafish
    (Danio rerio)
    Actinopterygii dusp141 dual specificity phosphatase 14 70.7(n)
    74.21(a)
      450040  NM_001006060.1  NP_001006060.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG155281 CG15528 48.43(n)
    41.18(a)
      43575  NM_143510.2  NP_651767.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C04F12.81 , 3 Dual specificity phosphatase, catalytic
    domain3
    Protein C04F12.81
    45(a)3
    49.22(n)1
    46.47(a)1
      I(9705535-9707799)3
    1822281  NM_060179.11  NP_492580.11 


    ENSEMBL Gene Tree for DUSP14 (if available)
    TreeFam Gene Tree for DUSP14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP14 gene
    DUSP42  DUSP212  SSH22  DUSP102  DUSP62  DUSP282  DUSP82  DUSP72  
    DUSP52  SSH32  DUSP162  DUSP92  DUSP22  DUSP182  SSH12  DUSP12  
    13 SIMAP similar genes for DUSP14 using alignment to 2 protein entries:     DUS14_HUMAN (see all proteins):
    DUSP18    DUSP21    DUSP26    DUSP6    DUSP9    DUSP7
    SSH2    DUSP10    DUSP13    DUSP16    SSH1    DUSP28
    DUSP8

    DUSP14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/546 SNPs in DUSP14 are shown (see all 546)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80744891,2
    C,F--35848033(+) atttcG/Atgttc 1 -- us2k13Minor allele frequency- A:0.20WA 122
    rs8531941,2
    C--35848045(+) gtagcC/Aacatg 1 -- us2k111Minor allele frequency- A:0.23NA WA CSA EA 372
    rs762259131,2
    C,F--35848134(+) GTCCAG/AAAGAG 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1175806771,2
    F--35848211(+) ATAAAG/CCGCCT 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1158199241,2
    F--35848227(+) CCCCAG/AGGCAT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs8531951,2
    C,F,A,H--35848255(+) ATGGTA/CTGACT 1 -- us2k123Minor allele frequency- C:0.22NS EA NA WA CSA 2350
    rs1915313831,2
    --35848266(+) CCAGCA/CCTTCT 1 -- us2k10--------
    rs1452603201,2
    C--35848277(+) TCTAC-/TTAA  
            
    TTAAT
    1 -- us2k10--------
    rs1828788381,2
    --35848280(+) TACTTA/GATCTC 1 -- us2k10--------
    rs1857090861,2
    --35848364(+) CTCTTC/GATGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DUSP14 (35849937 - 35873603 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DUSP14:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv269790CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606618    OMIM disorders: --

    4 diseases for DUSP14:    About MalaCards
    ataxia telangiectasia    ataxia    hepatocellular carcinoma    tuberculosis


    DUSP14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DUSP14

    Export disorders for DUSP14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP14 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with DUSP14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. (PubMed id 11123293)1, 2, 3, 9 Marti F....King P.D. (2001)
    2. Overproduction, purification and structure determinat ion of human dual-specificity phosphatase 14. (PubMed id 19770498)1, 2, 9 Lountos G.T....Waugh D.S. (2009)
    3. Genome-wide association analyses identifies a suscept ibility locus for tuberculosis on chromosome 18q11.2. (PubMed id 20694014)1, 4 Thye T....Hill A.V. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. GWAS meta-analysis and replication identifies three ne w susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (2013)
    6. The dual-specificity phosphatase DUSP14 negatively reg ulates tumor necrosis factor- and interleukin-1-induced nuclear factor-kB activa tion by dephosphorylating the protein kinase TAK1. (PubMed id 23229544)1 Zheng H....Shu H.B. (2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
    9. Deciphering the genetic architecture of variation in t he immune response to Mycobacterium tuberculosis infection. (PubMed id 22233810)1 Barreiro L.B....Gilad Y. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11072 HGNC: 17007 AceView: DUSP14 Ensembl:ENSG00000161326 euGenes: HUgn11072
    ECgene: DUSP14 Kegg: 11072 H-InvDB: DUSP14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP14 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DUSP14 gene:
    Search GeneIP for patents involving DUSP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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