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Aliases for DUSP14 Gene

Aliases for DUSP14 Gene

  • Dual Specificity Phosphatase 14 2 3
  • MKP6 3 4 6
  • Mitogen-Activated Protein Kinase Phosphatase 6 3 4
  • MKP-1 Like Protein Tyrosine Phosphatase 2 3
  • MKP-1-Like Protein Tyrosine Phosphatase 3 4
  • MAP Kinase Phosphatase 6 3 4
  • MKP-6 3 4
  • MKP-L 3 4
  • Dual Specificity Protein Phosphatase 14 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP14 Gene

Summaries for DUSP14 Gene

Entrez Gene Summary for DUSP14 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP14 Gene

DUSP14 (Dual Specificity Phosphatase 14) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and Hypertrophy Model. GO annotations related to this gene include protein tyrosine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot for DUSP14 Gene

  • Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP14 Gene

Genomics for DUSP14 Gene

Genomic Location for DUSP14 Gene

Start:
37,489,831 bp from pter
End:
37,513,501 bp from pter
Size:
23,671 bases
Orientation:
Plus strand

Genomic View for DUSP14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP14 Gene

Regulatory Elements for DUSP14 Gene

Proteins for DUSP14 Gene

  • Protein details for DUSP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95147-DUS14_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 14
    Protein Accession:
    O95147
    Secondary Accessions:

    Protein attributes for DUSP14 Gene

    Size:
    198 amino acids
    Molecular mass:
    22255 Da
    Quaternary structure:
    • Interacts with CD28.

    Three dimensional structures from OCA and Proteopedia for DUSP14 Gene

neXtProt entry for DUSP14 Gene

Proteomics data for DUSP14 Gene at MOPED

Post-translational modifications for DUSP14 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys187

Other Protein References for DUSP14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP14 Gene

Domains for DUSP14 Gene

Gene Families for DUSP14 Gene

HGNC:
  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Graphical View of Domain Structure for InterPro Entry

O95147

UniProtKB/Swiss-Prot:

DUS14_HUMAN
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.:
    • O95147
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.:
    • O95147
genes like me logo Genes that share domains with DUSP14: view

Function for DUSP14 Gene

Molecular function for DUSP14 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases

Enzyme Numbers (IUBMB) for DUSP14 Gene

Gene Ontology (GO) - Molecular Function for DUSP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP14: view

Phenotypes for DUSP14 Gene

GenomeRNAi human phenotypes for DUSP14:
genes like me logo Genes that share phenotypes with DUSP14: view

miRNA for DUSP14 Gene

miRTarBase miRNAs that target DUSP14

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUSP14 Gene

Localization for DUSP14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP14 Gene COMPARTMENTS Subcellular localization image for DUSP14 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP14 Gene

Pathways for DUSP14 Gene

SuperPathways for DUSP14 Gene

Superpath Contained pathways
1 TGF-Beta Pathway
2 Hypertrophy Model
genes like me logo Genes that share pathways with DUSP14: view

Pathways by source for DUSP14 Gene

1 Qiagen pathway for DUSP14 Gene
1 BioSystems pathway for DUSP14 Gene

Interacting Proteins for DUSP14 Gene

Selected Interacting proteins: O95147-DUS14_HUMAN for DUSP14 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for DUSP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0006470 protein dephosphorylation --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IBA --
genes like me logo Genes that share ontologies with DUSP14: view

Compounds for DUSP14 Gene

(3) HMDB Compounds for DUSP14 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with DUSP14: view

Transcripts for DUSP14 Gene

Unigene Clusters for DUSP14 Gene

Dual specificity phosphatase 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP14 Gene

No ASD Table

Relevant External Links for DUSP14 Gene

GeneLoc Exon Structure for
DUSP14
ECgene alternative splicing isoforms for
DUSP14

Expression for DUSP14 Gene

mRNA expression in normal human tissues for DUSP14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DUSP14 Gene

SOURCE GeneReport for Unigene cluster for DUSP14 Gene Hs.91448

genes like me logo Genes that share expressions with DUSP14: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUSP14 Gene

Orthologs for DUSP14 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP14 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia DUSP14 35
  • 91.25 (n)
  • 98.99 (a)
dog
(Canis familiaris)
Mammalia DUSP14 35
  • 92.76 (n)
  • 98.48 (a)
mouse
(Mus musculus)
Mammalia Dusp14 35
  • 90.74 (n)
  • 93.94 (a)
Dusp14 16
rat
(Rattus norvegicus)
Mammalia Dusp14 35
  • 90.74 (n)
  • 94.95 (a)
chicken
(Gallus gallus)
Aves DUSP14 35
  • 79.63 (n)
  • 85.35 (a)
zebrafish
(Danio rerio)
Actinopterygii dusp14 35
  • 70.7 (n)
  • 74.21 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006593 35
  • 54.56 (n)
  • 45.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15528 35
  • 48.43 (n)
  • 41.18 (a)
worm
(Caenorhabditis elegans)
Secernentea C04F12.8 35
  • 49.9 (n)
  • 46.75 (a)
C04F12.8 37
  • 45 (a)
Species with no ortholog for DUSP14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DUSP14 Gene

ENSEMBL:
Gene Tree for DUSP14 (if available)
TreeFam:
Gene Tree for DUSP14 (if available)

Paralogs for DUSP14 Gene

Selected SIMAP similar genes for DUSP14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP14: view

No data available for Paralogs for DUSP14 Gene

Variants for DUSP14 Gene

Sequence variations from dbSNP and Humsavar for DUSP14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2814 -- 37,513,300(-) AGCTG(G/T)TATCA utr-variant-3-prime
rs712039 -- 37,490,447(+) TTTCT(C/T)TGCGG intron-variant, upstream-variant-2KB
rs853194 -- 37,487,939(+) gtagc(A/C)acatg upstream-variant-2KB
rs853195 -- 37,488,149(+) ATGGT(A/C)TGACT upstream-variant-2KB
rs853196 -- 37,488,553(+) CAGGC(A/T)CGATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DUSP14 Gene

Variant ID Type Subtype PubMed ID
esv269790 CNV Insertion 20981092

Relevant External Links for DUSP14 Gene

HapMap Linkage Disequilibrium report
DUSP14
Human Gene Mutation Database (HGMD)
DUSP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP14 Gene

Disorders for DUSP14 Gene

Relevant External Links for DUSP14

Genetic Association Database (GAD)
DUSP14
genes like me logo Genes that share disorders with DUSP14: view

No data available for UniProtKB/Swiss-Prot for DUSP14 Gene

Publications for DUSP14 Gene

  1. Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. (PMID: 11123293) Marti F. … King P.D. (J. Immunol. 2001) 2 3 4 23
  2. Overproduction, purification and structure determination of human dual-specificity phosphatase 14. (PMID: 19770498) Lountos G.T. … Waugh D.S. (Acta Crystallogr. D 2009) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. (PMID: 20694014) Thye T. … Hill A.V. (Nat. Genet. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for DUSP14 Gene

Sources for DUSP14 Gene

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