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Aliases for DUSP14 Gene

Aliases for DUSP14 Gene

  • Dual Specificity Phosphatase 14 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 6 3 4
  • MKP-1-Like Protein Tyrosine Phosphatase 3 4
  • MAP Kinase Phosphatase 6 3 4
  • MKP-6 3 4
  • MKP-L 3 4
  • MKP6 3 4
  • MKP-1 Like Protein Tyrosine Phosphatase 2
  • Dual Specificity Protein Phosphatase 14 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP14 Gene

Previous GeneCards Identifiers for DUSP14 Gene

  • GC17P035255
  • GC17P037802
  • GC17P035580
  • GC17P036045
  • GC17P032924
  • GC17P035850
  • GC17P031787

Summaries for DUSP14 Gene

Entrez Gene Summary for DUSP14 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP14 Gene

DUSP14 (Dual Specificity Phosphatase 14) is a Protein Coding gene. Diseases associated with DUSP14 include Chromosome 17Q12 Deletion Syndrome. Among its related pathways are TGF-Beta Pathway and Hypertrophy Model. GO annotations related to this gene include poly(A) RNA binding and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP18.

UniProtKB/Swiss-Prot for DUSP14 Gene

  • Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP14 Gene

Genomics for DUSP14 Gene

Regulatory Elements for DUSP14 Gene

Enhancers for DUSP14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DUSP14 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP14 Gene

Chromosome:
17
Start:
37,488,561 bp from pter
End:
37,513,501 bp from pter
Size:
24,941 bases
Orientation:
Plus strand

Genomic View for DUSP14 Gene

Genes around DUSP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP14 Gene

Proteins for DUSP14 Gene

  • Protein details for DUSP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95147-DUS14_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 14
    Protein Accession:
    O95147

    Protein attributes for DUSP14 Gene

    Size:
    198 amino acids
    Molecular mass:
    22255 Da
    Quaternary structure:
    • Interacts with CD28.

    Three dimensional structures from OCA and Proteopedia for DUSP14 Gene

neXtProt entry for DUSP14 Gene

Post-translational modifications for DUSP14 Gene

  • Ubiquitination at Lys 187
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP14 Gene

Domains & Families for DUSP14 Gene

Gene Families for DUSP14 Gene

Graphical View of Domain Structure for InterPro Entry

O95147

UniProtKB/Swiss-Prot:

DUS14_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP14: view

Function for DUSP14 Gene

Molecular function for DUSP14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.

Enzyme Numbers (IUBMB) for DUSP14 Gene

Gene Ontology (GO) - Molecular Function for DUSP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with DUSP14: view
genes like me logo Genes that share phenotypes with DUSP14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP14

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP14 Gene

Localization for DUSP14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP14 Gene COMPARTMENTS Subcellular localization image for DUSP14 gene
Compartment Confidence
cytosol 3
mitochondrion 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP14 Gene

Pathways & Interactions for DUSP14 Gene

SuperPathways for DUSP14 Gene

Superpath Contained pathways
1 TGF-Beta Pathway
2 Hypertrophy Model
genes like me logo Genes that share pathways with DUSP14: view

Pathways by source for DUSP14 Gene

1 BioSystems pathway for DUSP14 Gene
1 Qiagen pathway for DUSP14 Gene

Interacting Proteins for DUSP14 Gene

Gene Ontology (GO) - Biological Process for DUSP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IBA --
genes like me logo Genes that share ontologies with DUSP14: view

No data available for SIGNOR curated interactions for DUSP14 Gene

Drugs & Compounds for DUSP14 Gene

(3) Drugs for DUSP14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0

(1) Additional Compounds for DUSP14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with DUSP14: view

Transcripts for DUSP14 Gene

mRNA/cDNA for DUSP14 Gene

Unigene Clusters for DUSP14 Gene

Dual specificity phosphatase 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP14 Gene

No ASD Table

Relevant External Links for DUSP14 Gene

GeneLoc Exon Structure for
DUSP14
ECgene alternative splicing isoforms for
DUSP14

Expression for DUSP14 Gene

mRNA expression in normal human tissues for DUSP14 Gene

Protein differential expression in normal tissues from HIPED for DUSP14 Gene

This gene is overexpressed in Cervix (30.0), Hair follicle (17.8), and Urine (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP14 Gene



NURSA nuclear receptor signaling pathways regulating expression of DUSP14 Gene:

DUSP14

SOURCE GeneReport for Unigene cluster for DUSP14 Gene:

Hs.91448
genes like me logo Genes that share expression patterns with DUSP14: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DUSP14 Gene

Orthologs for DUSP14 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUSP14 34
  • 91.25 (n)
  • 98.99 (a)
dog
(Canis familiaris)
Mammalia DUSP14 34
  • 92.76 (n)
  • 98.48 (a)
mouse
(Mus musculus)
Mammalia Dusp14 34
  • 90.74 (n)
  • 93.94 (a)
Dusp14 16
chimpanzee
(Pan troglodytes)
Mammalia DUSP14 34
  • 100 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Dusp14 34
  • 90.74 (n)
  • 94.95 (a)
chicken
(Gallus gallus)
Aves DUSP14 34
  • 79.63 (n)
  • 85.35 (a)
zebrafish
(Danio rerio)
Actinopterygii dusp14 34
  • 70.7 (n)
  • 74.21 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006593 34
  • 54.56 (n)
  • 45.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15528 34
  • 48.43 (n)
  • 41.18 (a)
worm
(Caenorhabditis elegans)
Secernentea C04F12.8 36
  • 45 (a)
C04F12.8 34
  • 49.9 (n)
  • 46.75 (a)
Species where no ortholog for DUSP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DUSP14 Gene

ENSEMBL:
Gene Tree for DUSP14 (if available)
TreeFam:
Gene Tree for DUSP14 (if available)

Paralogs for DUSP14 Gene

(13) SIMAP similar genes for DUSP14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP14: view

Variants for DUSP14 Gene

Sequence variations from dbSNP and Humsavar for DUSP14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2814 -- 37,513,300(-) AGCTG(G/T)TATCA utr-variant-3-prime
rs712039 -- 37,490,447(+) TTTCT(C/T)TGCGG intron-variant, upstream-variant-2KB
rs1051838 -- 37,510,731(+) GATCC(A/G)GACCC utr-variant-5-prime
rs1051840 -- 37,512,683(+) GAGGC(A/G)TACAA reference, synonymous-codon
rs1051849 -- 37,513,222(+) TCACT(C/T)TGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DUSP14 Gene

Variant ID Type Subtype PubMed ID
esv3305513 CNV mobile element insertion 20981092
esv3376555 CNV insertion 20981092
esv3640494 CNV gain 21293372
nsv1070826 CNV deletion 25765185
nsv1136235 CNV deletion 24896259

Variation tolerance for DUSP14 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP14 Gene

Human Gene Mutation Database (HGMD)
DUSP14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP14 Gene

Disorders for DUSP14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUSP14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 17q12 deletion syndrome
  • 17q12 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DUSP14

Genetic Association Database (GAD)
DUSP14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP14
genes like me logo Genes that share disorders with DUSP14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP14 Gene

Publications for DUSP14 Gene

  1. Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. (PMID: 11123293) Marti F. … King P.D. (J. Immunol. 2001) 2 3 4 22 65
  2. Overproduction, purification and structure determination of human dual-specificity phosphatase 14. (PMID: 19770498) Lountos G.T. … Waugh D.S. (Acta Crystallogr. D 2009) 3 4 22 65
  3. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. (PMID: 20694014) Thye T. … Hill A.V. (Nat. Genet. 2010) 3 46 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. (PMID: 26521044) Yang C.Y. … Tan T.H. (Cell. Signal. 2016) 3 65

Products for DUSP14 Gene

Sources for DUSP14 Gene

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