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Aliases for DUSP13 Gene

Aliases for DUSP13 Gene

  • Dual Specificity Phosphatase 13 2 3 5
  • Testis- And Skeletal-Muscle-Specific DSP 3 4
  • Branching-Enzyme Interacting DSP 3 4
  • Muscle-Restricted DSP 3 4
  • EC 3.1.3.16 4 4
  • EC 3.1.3.48 4 4
  • DUSP13A 3 4
  • DUSP13B 3 4
  • BEDP 3 4
  • MDSP 3 4
  • TMDP 3 4
  • Branching-Enzyme Interacting Dual-Specificity Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 13 3
  • Dual Specificity Phosphatase SKRP4 4
  • SKRP4 3

External Ids for DUSP13 Gene

Previous GeneCards Identifiers for DUSP13 Gene

  • GC10M075808
  • GC10M075957
  • GC10M076746
  • GC10M076198
  • GC10M076524
  • GC10M076854
  • GC10M070852

Summaries for DUSP13 Gene

Entrez Gene Summary for DUSP13 Gene

  • Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP13 Gene

DUSP13 (Dual Specificity Phosphatase 13) is a Protein Coding gene. Diseases associated with DUSP13 include Ruvalcaba Syndrome and Epilepsy, Progressive Myoclonic 2B. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUPD1.

UniProtKB/Swiss-Prot for DUSP13 Gene

  • Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.

  • Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.

Gene Wiki entry for DUSP13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP13 Gene

Genomics for DUSP13 Gene

Regulatory Elements for DUSP13 Gene

Enhancers for DUSP13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F075107 1.1 ENCODE 29.5 -1.3 -1309 5.5 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 KAT6B DUSP13 ENSG00000234149 LOC102723439 AP3M1 PPIAP13 RPS26P42
GH10F075201 0.8 Ensembl ENCODE 24.5 -93.3 -93339 2.2 KLF1 ZNF146 JUN ZNF223 KLF17 MAX FEZF1 THRB ZNF664 ZBTB48 DUSP13 COMTD1 VDAC2 PIR38247
GH10F075191 0.9 Ensembl ENCODE 23.4 -84.8 -84793 5.9 ATF1 ARNT ARID4B SIN3A BRCA1 YY1 GATA2 FOS ZNF263 JUNB DUSP13 ZNF503-AS1 PPIAP13 PIR38247 VDAC2
GH10F075103 1.1 FANTOM5 Ensembl ENCODE 19 +3.8 3805 3.2 BCOR SMARCA5 ZNF146 STAT1 NR2F1 ZMYM3 CEBPB ZFHX2 IKZF1 KDM1A DUSP13 ADK AP3M1 SAMD8
GH10F075116 0.7 Ensembl 16.7 -8.5 -8480 1.8 KLF1 ZFHX2 KLF17 CEBPB KLF9 ZEB1 EGR2 ZNF503-AS1 DUSP13 DUPD1 PPIAP13 RPS26P42
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DUSP13 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP13 Gene

Chromosome:
10
Start:
75,094,432 bp from pter
End:
75,109,221 bp from pter
Size:
14,790 bases
Orientation:
Minus strand

Genomic View for DUSP13 Gene

Genes around DUSP13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP13 Gene

Proteins for DUSP13 Gene

  • Protein details for DUSP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6B8I1-DS13A_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 13 isoform A
    Protein Accession:
    Q6B8I1
    Secondary Accessions:
    • Q96J67

    Protein attributes for DUSP13 Gene

    Size:
    188 amino acids
    Molecular mass:
    20658 Da
    Quaternary structure:
    • Interacts with MAP3K5/ASK1; may compete with AKT1 preventing MAP3K5/ASK1 phosphorylation by AKT1.
    SequenceCaution:
    • Sequence=AAH09778.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAF84580.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAF84586.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG51843.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG54592.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG62362.1; Type=Erroneous termination; Positions=3; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAG62362.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for DUSP13 Gene

  • Protein details for DUSP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UII6-DS13B_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 13 isoform B
    Protein Accession:
    Q9UII6
    Secondary Accessions:
    • A8K776
    • A8K782
    • B3KPY1
    • B3KXT0
    • B4DUK0
    • Q5JSC6
    • Q6IAR0
    • Q96GC2

    Protein attributes for DUSP13 Gene

    Size:
    198 amino acids
    Molecular mass:
    22149 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP13 Gene

    Alternative splice isoforms for DUSP13 Gene

neXtProt entry for DUSP13 Gene

Post-translational modifications for DUSP13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUSP13 Gene

Domains & Families for DUSP13 Gene

Gene Families for DUSP13 Gene

Suggested Antigen Peptide Sequences for DUSP13 Gene

Graphical View of Domain Structure for InterPro Entry

Q6B8I1

UniProtKB/Swiss-Prot:

DS13B_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP13: view

Function for DUSP13 Gene

Molecular function for DUSP13 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.5 mM for p-nitrophenol phosphate (at pH 6.0) {ECO:0000269 PubMed:15252030};
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate.
UniProtKB/Swiss-Prot Function:
Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.
UniProtKB/Swiss-Prot Function:
Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.

Enzyme Numbers (IUBMB) for DUSP13 Gene

Gene Ontology (GO) - Molecular Function for DUSP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA,TAS --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IDA 24531476
genes like me logo Genes that share ontologies with DUSP13: view
genes like me logo Genes that share phenotypes with DUSP13: view

Animal Model Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUSP13 Gene

Localization for DUSP13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP13 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP13 Gene COMPARTMENTS Subcellular localization image for DUSP13 gene
Compartment Confidence
extracellular 3
chloroplast 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DUSP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DUSP13: view

Pathways & Interactions for DUSP13 Gene

SuperPathways for DUSP13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 10585869
GO:0007126 meiotic nuclear division TAS 10585869
GO:0007283 spermatogenesis TAS 10585869
GO:0016311 dephosphorylation IDA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP13: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP13 Gene

Drugs & Compounds for DUSP13 Gene

(9) Drugs for DUSP13 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0

(9) Additional Compounds for DUSP13 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with DUSP13: view

Transcripts for DUSP13 Gene

Unigene Clusters for DUSP13 Gene

Dual specificity phosphatase 13:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: - - - - - - -
SP4:
SP5: -
SP6: - - - -
SP7: - - - - - - - -
SP8: -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: -

Relevant External Links for DUSP13 Gene

GeneLoc Exon Structure for
DUSP13
ECgene alternative splicing isoforms for
DUSP13

Expression for DUSP13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP13 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP13 Gene

This gene is overexpressed in Muscle - Skeletal (x38.7) and Testis (x6.2).

Protein differential expression in normal tissues from HIPED for DUSP13 Gene

This gene is overexpressed in Spleen (54.3) and Liver (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP13 Gene



Protein tissue co-expression partners for DUSP13 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP13 Gene:

DUSP13

SOURCE GeneReport for Unigene cluster for DUSP13 Gene:

Hs.178170

mRNA Expression by UniProt/SwissProt for DUSP13 Gene:

Q6B8I1-DS13A_HUMAN
Tissue specificity: Skeletal muscle specific.
genes like me logo Genes that share expression patterns with DUSP13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DUSP13 Gene

Orthologs for DUSP13 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP13 34 35
  • 98.74 (n)
cow
(Bos Taurus)
Mammalia DUSP13 34
  • 91.08 (n)
-- 35
  • 22 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia DUSP13 34
  • 89.56 (n)
-- 35
  • 22 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Dusp13 34 16 35
  • 83.41 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909469 34
  • 80.71 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP13 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP13 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP13 34 35
  • 65.97 (n)
lizard
(Anolis carolinensis)
Reptilia DUSP13 35
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:172281 34
  • 60 (n)
DUSP13 (3 of 3) 35
  • 60 (a)
OneToMany
DUSP13 (1 of 3) 35
  • 52 (a)
OneToMany
DUSP13 (2 of 3) 35
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7378 35
  • 39 (a)
OneToMany
Species where no ortholog for DUSP13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP13 Gene

ENSEMBL:
Gene Tree for DUSP13 (if available)
TreeFam:
Gene Tree for DUSP13 (if available)

Paralogs for DUSP13 Gene

genes like me logo Genes that share paralogs with DUSP13: view

Variants for DUSP13 Gene

Sequence variations from dbSNP and Humsavar for DUSP13 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10128220 -- 75,102,528(+) CTTGG(A/C)CGGAT intron-variant
rs10762657 -- 75,099,007(+) GCCTA(C/T)AGGCC intron-variant, upstream-variant-2KB
rs10824271 -- 75,096,113(+) AGCCA(A/G)GCATG intron-variant
rs10824272 -- 75,096,364(+) TTGAG(C/T)TCAGG intron-variant
rs10824273 -- 75,102,162(+) GGCAT(A/T)TTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP13 Gene

Variant ID Type Subtype PubMed ID
dgv927n100 CNV gain 25217958
nsv516793 CNV gain 19592680
nsv518639 CNV loss 19592680
nsv7199 CNV insertion 18451855
nsv831913 CNV loss 17160897

Variation tolerance for DUSP13 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.71; 96.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP13 Gene

Disorders for DUSP13 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DUSP13 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
ruvalcaba syndrome
epilepsy, progressive myoclonic 2b
  • epilepsy, progressive myoclonic 2a
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DUSP13

Genetic Association Database (GAD)
DUSP13
Human Genome Epidemiology (HuGE) Navigator
DUSP13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP13
genes like me logo Genes that share disorders with DUSP13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP13 Gene

Publications for DUSP13 Gene

  1. Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. (PMID: 10585869) Nakamura K. … Kikuchi K. (Biochem. J. 1999) 2 3 4 22 64
  2. Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. (PMID: 17044055) Kim S.J. … Kim J.H. (Proteins 2007) 3 4 22 64
  3. Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. (PMID: 15252030) Chen H.-H. … Tonks N.K. (J. Biol. Chem. 2004) 3 4 22 64
  4. DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression. (PMID: 21360282) Katagiri C. … Shima H. (Mol. Cell. Biochem. 2011) 3 4 64
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64

Products for DUSP13 Gene

Sources for DUSP13 Gene

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