Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DUSP13 Gene

protein-coding   GIFtS: 55
GCID: GC10M076854

Dual Specificity Phosphatase 13

  See DUSP13-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dual Specificity Phosphatase 131 2     DUSP13B2 3
MDSP2 3 5     SKRP42
TMDP2 3 5     Branching-Enzyme Interacting Dual-Specificity Protein Phosphatase2
Branching-Enzyme Interacting DSP2 3     Dual Specificity Protein Phosphatase 132
Muscle-Restricted DSP2 3     EC 3.1.3.163
Testis- And Skeletal-Muscle-Specific DSP2 3     EC 3.1.3.483
BEDP2 3     Dual Specificity Phosphatase SKRP43
DUSP13A2 3     

External Ids:    HGNC: 196811   Entrez Gene: 512072   Ensembl: ENSG000000793937   OMIM: 6131915   UniProtKB: Q6B8I13   
UniProtKB: Q9UII63   

Export aliases for DUSP13 gene to outside databases

Previous GC identifers: GC10M075808 GC10M075957 GC10M076746 GC10M076198 GC10M076524 GC10M070852


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DUSP13 Gene:
Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell
proliferation and differentiation. This superfamily is separated into two families based on the substrate that is
dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and
phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of
non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters.
Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be
involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in
skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a
similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but
the full-length sequence of only some were determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for DUSP13 Gene:
DUSP13 (dual specificity phosphatase 13) is a protein-coding gene. Diseases associated with DUSP13 include bannayan-riley-ruvalcaba syndrome, and ruvalcaba syndrome. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot: DS13B_HUMAN, Q9UII6
Function: Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in
vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with
similar specific activities in vitro

Gene Wiki entry for DUSP13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP13 gene promoter:
         GR   NF-1   NF-1/L   FOXF2   GR-beta   AREB6   HOXA5   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP13 promoter sequence
   Search Chromatin IP Primers for DUSP13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q23.1

DUSP13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP13 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M076854:  view genomic region     (about GC identifiers)

Start:
76,854,190 bp from pter      End:
76,868,979 bp from pter
Size:
14,790 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DS13A_HUMAN, Q6B8I1 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 13 isoform A  
Size: 188 amino acids; 20658 Da
Subunit: Interacts with MAP3K5/ASK1; may compete with AKT1 preventing MAP3K5/ASK1 phosphorylation by AKT1
Sequence caution: Sequence=AAH09778.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAF84580.1;
Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAF84586.1; Type=Erroneous translation; Note=Wrong
choice of CDS; Sequence=BAG51843.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG54592.1;
Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG62362.1; Type=Erroneous termination;
Positions=3; Note=Translated as Glu; Sequence=BAG62362.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q96J67
Alternative promoter usage, Alternative splicing: 7 isoforms:  Q6B8I1-1   Q9UII6-1   Q6B8I1-5   Q9UII6-4   Q6B8I1-2   Q6B8I1-3   Q6B8I1-4   (Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

UniProtKB/Swiss-Prot: DS13B_HUMAN, Q9UII6 (See protein sequence)

Recommended Name: Dual specificity protein phosphatase 13 isoform B  
Size: 198 amino acids; 22149 Da
2 PDB 3D structures from and Proteopedia for DUSP13:
2GWO (3D)        2PQ5 (3D)    
Secondary accessions: A8K776 A8K782 B3KPY1 B3KXT0 B4DUK0 Q5JSC6 Q6IAR0 Q96GC2
Alternative promoter usage, Alternative splicing: 7 isoforms:  Q9UII6-1   Q6B8I1-5   Q9UII6-4   Q6B8I1-1   Q6B8I1-2   Q6B8I1-3   Q6B8I1-4   (Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DUSP13: NX_Q9UII6

Explore proteomics data for DUSP13 at MOPED


See DUSP13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_001007272.1  NP_001007273.1  NP_001007274.1  NP_057448.3  

ENSEMBL proteins: 
 ENSP00000444580   ENSP00000361787   ENSP00000434041   ENSP00000475675   ENSP00000475626  
 ENSP00000311051   ENSP00000474298   ENSP00000452702   ENSP00000474689   ENSP00000361785  
 ENSP00000475851   ENSP00000475732   ENSP00000436312   ENSP00000475801  

DUSP13 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Proteins for DUSP13
OriGene Protein Over-expression Lysate for DUSP13
OriGene MassSpec for DUSP13
OriGene Custom Protein Services for DUSP13
GenScript Custom Purified and Recombinant Proteins Services for DUSP13
Novus Biologicals DUSP13 Proteins
Novus Biologicals DUSP13 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for DUSP13
Cloud-Clone Corp. Proteins for DUSP13

 
Search eBioscience for Proteins for DUSP13 

DUSP13 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for DUSP13
Novus Biologicals DUSP13 Antibodies
Abcam antibodies for DUSP13
Cloud-Clone Corp. Antibodies for DUSP13
ThermoFisher Antibodies for DUSP13
LSBio Antibodies in human, mouse, rat for DUSP13

DUSP13 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DUSP13
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for DUSP13
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for DUSP13
Cloud-Clone Corp. CLIAs for DUSP13
Search eBioscience for ELISAs for DUSP13 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Selected InterPro protein domains (see all 7):
 IPR000387 Tyr/Dual-sp_Pase
 IPR020422 Dual-sp_phosphatase_subgr_cat
 IPR016130 Tyr_Pase_AS
 IPR020417 Atypical_DUSP
 IPR024950 DUSP

Graphical View of Domain Structure for InterPro Entry Q6B8I1
Graphical View of Domain Structure for InterPro Entry Q9UII6

ProtoNet protein and cluster: Q6B8I1

1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

UniProtKB/Swiss-Prot: DS13A_HUMAN, Q6B8I1
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
Similarity: Contains 1 tyrosine-protein phosphatase domain

UniProtKB/Swiss-Prot: DS13B_HUMAN, Q9UII6
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
Similarity: Contains 1 tyrosine-protein phosphatase domain


Find genes that share domains with DUSP13           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: DS13A_HUMAN, Q6B8I1
Function: Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in
MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on
MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Enzyme regulation: Inhibited by vanadate
Biophysicochemical properties: Kinetic parameters: KM=7.5 mM for p-nitrophenol phosphate (at pH 6.0);

     UniProtKB/Swiss-Prot: DS13B_HUMAN, Q9UII6
Function: Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in
vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with
similar specific activities in vitro
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

     Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004725protein tyrosine phosphatase activity IEA--
GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
GO:0016791phosphatase activity ----
     
Find genes that share ontologies with DUSP13           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for DUSP13:
 Decreased cilium length after   Increased apoptosis 

     1 MGI phenotypic allele for Dusp13 (no phenotypes)

Find genes that share phenotypes with DUSP13           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP13
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DUSP13

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP13
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP13

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat DUSP13 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate DUSP13:
hsa-miR-1266 hsa-miR-186 hsa-miR-3133
SwitchGear 3'UTR luciferase reporter plasmidDUSP13 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DUSP13
Predesigned siRNA for gene silencing in human, mouse, rat DUSP13

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DUSP13

Clone
Products:
     
OriGene clones in human, mouse for DUSP13 (see all 18)
OriGene ORF clones in mouse, rat for DUSP13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): DUSP13 (NM_001007272)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP13
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP13

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DUSP13
Browse ESI BIO Cell Lines and PureStem Progenitors for DUSP13 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP13


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
DS13A_HUMAN, Q6B8I1: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytosol1
endoplasmic reticulum1
nucleus1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA15252030

Find genes that share ontologies with DUSP13           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DUSP13
Interactions:

    Search GeneGlobe Interaction Network for DUSP13

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

Selected Interacting proteins for DUSP13 (Q9UII62, 3 ENSP000003617874 Q6B8I12, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
CCDC85BQ158342, ENSP000003116954MINT-67607 STRING: ENSP00000311695
ACVR1ENSP000002636404STRING: ENSP00000263640
SMURF1ENSP000003546214STRING: ENSP00000354621
TGFBR1ENSP000003641334STRING: ENSP00000364133
MRTO4ENSP000003643204STRING: ENSP00000364320
About this table

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006470protein dephosphorylation IBA--
GO:0007126meiotic nuclear division TAS10585869
GO:0007283spermatogenesis TAS10585869
GO:0016311dephosphorylation ----

Find genes that share ontologies with DUSP13           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DUSP13 (DS13B)

3 HMDB Compounds for DUSP13    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
PhosphateNFB Orthophosphate (see all 13)14265-44-2--
WaterDihydrogen oxide (see all 2)7732-18-5--

Selected Novoseek inferred chemical compound relationships for DUSP13 gene (see all 14)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cl 100 81.4 3 8390041 (1), 8910287 (1), 9119028 (1)
phosphothreonine 73.2 3 10620697 (1), 10627275 (1), 17044055 (1)
phosphotyrosine 71.8 7 11001928 (1), 10620697 (1), 11341829 (1), 15252030 (1) (see all 7)
phosphoserine 70.9 3 11001928 (1), 15252030 (1), 19426873 (1)
threonine 63.3 12 9030581 (1), 11001928 (1), 18669639 (1), 20139719 (1) (see all 11)
tyrosine 56.4 19 17044055 (3), 9030581 (1), 10543950 (1), 8242750 (1) (see all 15)
tungstate 53.8 1 10543950 (1)
serine 39.4 5 18669639 (1), 11341829 (1), 16988418 (1), 20180778 (1) (see all 5)
cysteine 29.7 2 15541888 (1), 8128219 (1)
phosphatidylinositol 16.9 2 15090541 (1), 10400993 (1)



Find genes that share compounds with DUSP13           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DUSP13 gene (6 alternative transcripts): 
NM_001007271.1  NM_001007272.1  NM_001007273.1  NM_016364.3  NM_001007274.1  NM_001007275.1  

Unigene Cluster for DUSP13:

Dual specificity phosphatase 13
Hs.178170  [show with all ESTs]
Unigene Representative Sequence: NM_001007271
15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000472493(uc001jwr.3) ENST00000372702 ENST00000464872 ENST00000605915
ENST00000478873 ENST00000308475 ENST00000479884 ENST00000394707 ENST00000494588
ENST00000372700 ENST00000607487 ENST00000607009 ENST00000473072 ENST00000491677(uc001jws.3 uc001jwu.3 uc001jww.3 uc009xrs.3 uc001jwt.3 uc001jwv.3)
ENST00000607131
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DUSP13 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate DUSP13:
hsa-miR-1266 hsa-miR-186 hsa-miR-3133
SwitchGear 3'UTR luciferase reporter plasmidDUSP13 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DUSP13
Predesigned siRNA for gene silencing in human, mouse, rat DUSP13
Clone
Products:
     
OriGene clones in human, mouse for DUSP13 (see all 18)
OriGene ORF clones in mouse, rat for DUSP13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): DUSP13 (NM_001007272)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP13
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP13
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DUSP13
OriGene qSTAR qPCR primer pairs in human, mouse for DUSP13
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DUSP13
  QuantiTect SYBR Green Assays in human, mouse, rat DUSP13
  QuantiFast Probe-based Assays in human, mouse, rat DUSP13

Additional mRNA sequence: 

AB027004.1 AB103375.1 AK057012.1 AK127886.1 AK291891.1 AK291897.1 AK300679.1 AY040091.1 
AY674051.1 BC009778.1 CR457094.1 

8 DOTS entries:

DT.99954558  DT.92414714  DT.40114008  DT.311925  DT.95369993  DT.101981171  DT.121267042  DT.91722178 

Selected AceView cDNA sequences (see all 35):

AY674051 F24441 AW444890 AJ571820 BX500580 NM_016364 AA774585 BU580940 
AK127886 BF212271 AY040091 BC009778 AI971328 F19634 F36785 AB027004 
AA435513 AA602372 AK057012 AA346094 BI835341 BX091889 AA723271 CR457094 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DUSP13 (see all 11)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1:                          -                                         -                                                         
SP2:                          -           -                             -                                                         
SP3:                          -     -     -     -     -     -           -                                                         
SP4:                                                                                                                              
SP5:                          -                                                                                                   


ECgene alternative splicing isoforms for DUSP13

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DUSP13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACGCTGGTAG
DUSP13 Expression
About this image

DUSP13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DUSP13 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.178170

UniProtKB/Swiss-Prot: DS13A_HUMAN, Q6B8I1
Tissue specificity: Skeletal muscle specific

UniProtKB/Swiss-Prot: DS13B_HUMAN, Q9UII6
Tissue specificity: Most abundantly expressed in the testis. Also found in the skeletal muscle. Testis-specific
(at protein level)

    Custom PCR Arrays for DUSP13
Primer
Products:
OriGene qPCR primer pairs and template standards for DUSP13
OriGene qSTAR qPCR primer pairs in human, mouse for DUSP13
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DUSP13
QuantiTect SYBR Green Assays in human, mouse, rat DUSP13
QuantiFast Probe-based Assays in human, mouse, rat DUSP13
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP13

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for DUSP13 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dusp131 , 5 dual specificity phosphatase 131, 5 83.41(n)1
85.17(a)1
  14 (11.85 cM)5
273891  NM_013849.31  NP_038877.21 
 217333945 
chicken
(Gallus gallus)
Aves DUSP131 dual specificity phosphatase 13 65.97(n)
65.62(a)
  423732  XM_421607.3  XP_421607.3 
lizard
(Anolis carolinensis)
Reptilia DUSP136
dual specificity phosphatase 13
56(a)
1 ↔ 1
GL343196.1(2451149-2505885)
zebrafish
(Danio rerio)
Actinopterygii zgc:1722811 zgc:172281 60(n)
58.24(a)
  568887  NM_001110395.1  NP_001103865.1 
fruit fly
(Drosophila melanogaster)
Insecta CG73786
--
39(a)
1 → many
X(18794443-18803330)


ENSEMBL Gene Tree for DUSP13 (if available)
TreeFam Gene Tree for DUSP13 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for DUSP13 gene
DUSP262  DUSP212  DUPD12  DUSP32  DUSP272  STYX2  DUSP142  DUSP192  
DUSP282  DUSP152  DUSP222  DUSP182  
10 SIMAP similar genes for DUSP13 using alignment to 9 protein entries:     DS13A_HUMAN (see all proteins):
DUSP3    DUSP27    DUPD1    DUSP26    DUSP18    DUSP9
DUSP21    DUSP16    DUSP14    DUSP22

Find genes that share paralogs with DUSP13           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for DUSP13 (see all 363)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1132539421,2
C--76853779(+) TTTGTG/TAGGAG 4 -- ds50011Minor allele frequency- T:0.50CSA 2
rs1821199261,2
--76853889(+) TTGGGA/TAGGAT 4 -- ds50010--------
rs1451682061,2
C--76853902(+) GCATGA/GAGATA 4 -- ds50010--------
rs1856481611,2
--76853954(+) CTATTA/GGGTGA 4 -- ds50010--------
rs665812781,2
C--76853964(+) AGGGT-/ATGAGG
AGGACAAG
ATGAG
4 -- ds50011Minor allele frequency- ATGAGGAGGACAAG:0.50CSA 2
rs724055471,2
C--76853971(+) GAGGA-/GGACAA
GATGAGGA
CGAGG
4 -- ds50010--------
rs748079151,2
C--76853985(+) GAGGAC/GGACAA 4 -- ds50010--------
rs1389910691,2
--76854063(+) TATCAC/TGAATT 4 -- ds50010--------
rs1489348681,2
--76854090(+) CTCCCC/TGAGGC 4 -- ds50010--------
rs169319941,2
C,F,H--76854117(+) CAGAGT/GTGGCA 4 -- ds500121Minor allele frequency- G:0.26NA NS EA WA 2482

HapMap Linkage Disequilibrium report for DUSP13 (76854190 - 76868979 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for DUSP13:    About this table    
Variant IDTypeSubtypePubMed ID
nsv7199CNV Insertion18451855
nsv831913CNV Loss17160897
nsv518639CNV Loss19592680
nsv516793CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DUSP13
DNA2.0 Custom Variant and Variant Library Synthesis for DUSP13

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 613191    OMIM disorders: --

5 diseases for DUSP13:    
About MalaCards
bannayan-riley-ruvalcaba syndrome    ruvalcaba syndrome    juvenile polyposis syndrome    cowden disease
endometrial carcinoma

1 disease from the University of Copenhagen DISEASES database for DUSP13:
Vaccinia

Find genes that share disorders with DUSP13           About GenesLikeMe

7 Novoseek inferred disease relationships for DUSP13 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lafora disease 77.2 1 11579433 (1)
myopathy 19.1 1 9689104 (1)
endometrial carcinoma 12.1 1 10568810 (1)
tumors 7.29 7 19074854 (1), 11021816 (1), 12717346 (1), 15532706 (1) (see all 7)
cancer 5.99 3 11021816 (1), 12717346 (1), 20477815 (1)
prostate cancer 4.38 2 12717346 (1), 19501628 (1)
genetic disorder 0.832 1 11686296 (1)

Genetic Association Database (GAD): DUSP13
Human Genome Epidemiology (HuGE) Navigator: DUSP13 (2 documents)

Export disorders for DUSP13 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DUSP13 gene, integrated from 10 sources (see all 128):
(articles sorted by number of sources associating them with DUSP13)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. (PubMed id 10585869)1, 2, 3, 9 Nakamura K.... Kikuchi K. (Biochem. J. 1999)
  2. Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. (PubMed id 15252030)1, 2, 9 Chen H.-H.... Tonks N.K. (J. Biol. Chem. 2004)
  3. Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. (PubMed id 17044055)1, 2, 9 Kim S.J....Kim J.H. (Proteins 2007)
  4. DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression. (PubMed id 21360282)1, 2 Katagiri C....Shima H. (Mol. Cell. Biochem. 2011)
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
  6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
  7. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
  8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  9. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 51207 HGNC: 19681 AceView: DUSP13 Ensembl:ENSG00000079393 euGenes: HUgn51207
ECgene: DUSP13 H-InvDB: DUSP13

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for DUSP13 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for DUSP13 gene:
Search GeneIP for patents involving DUSP13

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DUSP13  
 OriGene qPCR primer pairs and template standards for DUSP13   OriGene Protein Over-expression Lysate for DUSP13  
 OriGene MassSpec something-or-other for DUSP13   OriGene clones in human, mouse for DUSP13  
 OriGene qSTAR qPCR primer pairs in human, mouse for DUSP13   OriGene Purified Protein for DUSP13  
 OriGene ORF clones in mouse, rat for DUSP13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DUSP13   OriGene Custom Protein Services for DUSP13  

 
 
 Block miRNA regulation of human, mouse, rat DUSP13 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DUSP13
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP13 Predesigned siRNA for gene silencing in human, mouse, rat DUSP13
 QuantiFast Probe-based Assays in human, mouse, rat DUSP13 QuantiTect SYBR Green Assays in human, mouse, rat DUSP13
 Custom PCR Arrays for DUSP13 Search Chromatin IP Primers for DUSP13
 Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DUSP13  Search GeneGlobe Interaction Network for DUSP13
 Regulatory tfbs in DUSP13 promoter
 GenScript Custom Purified and Recombinant Proteins Services for DUSP13 GenScript cDNA clones with any tag delivered in your preferred vector for DUSP13
 GenScript Custom Assay Services for DUSP13 GenScript Custom overexpressing Cell Line Services for DUSP13
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for DUSP13 (DS13B)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 DUSP13 antibodies
 DUSP13 proteins
 DUSP13 lysates
 Antibodies for DUSP13
 See all of Abcam's Antibodies, Kits and Proteins for DUSP13
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for DUSP13
 Proteins for DUSP13
 Antibodies for DUSP13
 ELISAs for DUSP13
 CLIAs for DUSP13



 Browse ESI BIO Cell Lines and PureStem Progenitors for DUSP13
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP13
 SwitchGear 3'UTR luciferase reporter plasmids for DUSP13
 SwitchGear Promoter luciferase reporter plasmids for DUSP13
 ThermoFisher Antibodies for DUSP13
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP13
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP13
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DUSP13
 LSBio Antibodies in human, mouse, rat for DUSP13
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for DUSP13
  Search eBioscience for proteins for DUSP13
  Search eBioscience for elisas for DUSP13
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DUSP13 gene at Home site.
Version: 3.12.224 13 Oct 2014
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4