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DUSP12 Gene

protein-coding   GIFtS: 57
GCID: GC01P161719

Dual Specificity Phosphatase 12

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 121 2     YVH1 Protein-Tyrosine Phosphatase (S. Cerevisiae) Ortholog1
Serine/Threonine Specific Protein Phosphatase1 2     Dual Specificity Protein Phosphatase 122
Dual Specificity Tyrosine Phosphatase YVH12 3     YVH1 Protein-Tyrosine Phosphatase Ortholog2
DUSP12 5     EC 3.1.3.163
YVH12 5     EC 3.1.3.483

External Ids:    HGNC: 30671   Entrez Gene: 112662   Ensembl: ENSG000000817217   OMIM: 6048355   UniProtKB: Q9UNI63   

Export aliases for DUSP12 gene to outside databases

Previous GC identifers: GC01P159354 GC01P157370 GC01P158415 GC01P158906 GC01P158451 GC01P159989 GC01P132964


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP12 Gene:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These
phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and
phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase
superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for
various MAP kinases, different tissue distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the
Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is
novel in that it contains, and is regulated by a zinc finger domain. (provided by RefSeq, Jul 2008)

GeneCards Summary for DUSP12 Gene:
DUSP12 (dual specificity phosphatase 12) is a protein-coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity.

Gene Wiki entry for DUSP12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP12 gene promoter:
         STAT1   AML1a   STAT4   STAT1beta   STAT1alpha   CREB   deltaCREB   STAT2   STAT3   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP12 promoter sequence
   Search Chromatin IP Primers for DUSP12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q21-q22

DUSP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP12 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161719:  view genomic region     (about GC identifiers)

Start:
161,719,548 bp from pter      End:
161,727,028 bp from pter
Size:
7,481 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DUS12_HUMAN, Q9UNI6 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 12  
Size: 340 amino acids; 37687 Da
Cofactor: Binds 2 zinc ions per subunit
Secondary accessions: Q5VXA8

Explore the universe of human proteins at neXtProt for DUSP12: NX_Q9UNI6

Explore proteomics data for DUSP12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DUSP12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009171.1  
    ENSEMBL proteins: 
     ENSP00000476528   ENSP00000356920   ENSP00000476912   ENSP00000477122  

    DUSP12 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DUSP12

     
    Search eBioscience for Proteins for DUSP12 

     
    antibodies-online proteins for DUSP12 (7 products) 

     
    antibodies-online peptides for DUSP12

    DUSP12 Antibody Products:

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    DUSP12 Assay Products:

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    Cloud-Clone Corp. CLIAs for DUSP12
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    antibodies-online kits for DUSP12 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

    Selected InterPro protein domains (see all 6):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom
     IPR016278 DUSP12

    Graphical View of Domain Structure for InterPro Entry Q9UNI6

    ProtoNet protein and cluster: Q9UNI6

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: DUS12_HUMAN, Q9UNI6
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with DUSP12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS12_HUMAN, Q9UNI6
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Genatlas biochemistry entry for DUSP12:
    dual specificity phosphatase 12

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
    GO:0008270zinc ion binding TAS10446167
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with DUSP12           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DUSP12:
     Decreased focal adhesion (FA)   Increased apoptosis 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DUSP12

    miRNA
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    miRTarBase miRNAs that target DUSP12:
    hsa-let-7b-5p (MIRT001636), hsa-mir-26b-5p (MIRT030074)

    Block miRNA regulation of human, mouse, rat DUSP12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DUSP12:
    hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidDUSP12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DUSP12
    Predesigned siRNA for gene silencing in human, mouse, rat DUSP12

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP12

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS12_HUMAN, Q9UNI6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with DUSP12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DUSP12
        ERK Signaling
    NTHi-Induced Signaling
    Aldosterone Signaling in Epithelial Cells
    JNK Pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP12: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DUSP12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DUSP12 (Q9UNI62, 3 ENSP000003569204) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MBD6Q96DN62, 3, ENSP000003478964MINT-65783 I2D: score=5 STRING: ENSP00000347896
    KIAA1377Q9P2H02, 3MINT-65784 I2D: score=5 
    PTNP212462, 3MINT-65782 I2D: score=5 
    RABAC1Q9UI142, 3, ENSP000002220084MINT-67416 I2D: score=5 STRING: ENSP00000222008
    NR1H2P550552, 3, ENSP000002537274MINT-8254567 I2D: score=2 STRING: ENSP00000253727
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS10446167
    GO:0006470protein dephosphorylation IBA--
    GO:0007254NOT JNK cascade IRD--
    GO:0016311dephosphorylation ----
    GO:0033133positive regulation of glucokinase activity IBA--

    Find genes that share ontologies with DUSP12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP12 (DUS12)

    3 HMDB Compounds for DUSP12    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DUSP12 gene: 
    NM_007240.1  

    Unigene Cluster for DUSP12:

    Dual specificity phosphatase 12
    Hs.416216  [show with all ESTs]
    Unigene Representative Sequence: BC006286
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484291 ENST00000367943(uc001gbo.3) ENST00000464004 ENST00000490591
    ENST00000463365
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate DUSP12:
    hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidDUSP12 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DUSP12
    Predesigned siRNA for gene silencing in human, mouse, rat DUSP12
    Clone
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    OriGene clones in human, mouse for DUSP12 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: DUSP12 (NM_007240)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP12
    Primer
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    OriGene qPCR primer pairs and template standards for DUSP12
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP12
      QuantiTect SYBR Green Assays in human, mouse, rat DUSP12
      QuantiFast Probe-based Assays in human, mouse, rat DUSP12

    Additional mRNA sequence: 

    AF119226.1 AK000259.1 BC006286.1 BT006633.1 

    6 DOTS entries:

    DT.86839113  DT.441722  DT.91743497  DT.100678121  DT.100779348  DT.100839118 

    Selected AceView cDNA sequences (see all 161):

    CB146889 AW511560 BM824434 BQ423889 CA776245 AI368582 BQ574040 BM782644 
    AA031673 AL047655 BM714291 BM782356 BM708890 BM782671 CR619976 AA147450 
    AK000259 CR599391 CB159708 BM999738 CR603104 BU181951 CB240728 AA485951 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP12    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                      -     -                                       
    SP2:                                      -                                             
    SP3:                                -     -                                             
    SP4:                                      -     -     -                                 
    SP5:                                -                                                   


    ECgene alternative splicing isoforms for DUSP12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUSP12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATTTTAT
    DUSP12 Expression
    About this image

    DUSP12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.416216

    UniProtKB/Swiss-Prot: DUS12_HUMAN, Q9UNI6
    Tissue specificity: Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and
    lower expression in liver and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP12: 
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUSP12 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp121 , 5 dual specificity phosphatase 121, 5 82.1(n)1
    83.78(a)1
      1 (77.27 cM)5
    809151  NM_023173.21  NP_075662.21 
     1708734985 
    chicken
    (Gallus gallus)
    Aves DUSP121 dual specificity phosphatase 12 64.5(n)
    63.31(a)
      425349  NM_001278099.1  NP_001265028.1 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP126
    dual specificity phosphatase 12
    59(a)
    1 ↔ 1
    GL343218.1(938623-948877)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162072 Xenopus laevis transcribed sequence with weak similarity more 79.57(n)    BJ098033.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dusp121 dual specificity phosphatase 12 62.02(n)
    62.59(a)
      573998  NM_001025177.1  NP_001020348.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MKP-41 MAPK Phosphatase 4 45.3(n)
    39.02(a)
      32963  NM_134488.2  NP_608332.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C24F3.26
    Protein C24F3.2 (C24F3.2) mRNA, complete cds
    28(a)
    1 ↔ 1
    IV(10222511-10223751) WBGene00007697
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YVH1(YIR026C)4
    YVH11
    Protein phosphatase involved in vegetative growth at more4
    YVH11
    44.71(n)1
    35.52(a)1
      9(405967-404873)4
    8548441, 4  NP_012292.31  NP_012292.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G185931 AT4G18593 49.85(n)
    46.02(a)
      827592  NM_117974.2  NP_567561.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g01337001 Os12g0133700 52.1(n)
    44.09(a)
      4351431  NM_001072622.1  NP_001066090.1 


    ENSEMBL Gene Tree for DUSP12 (if available)
    TreeFam Gene Tree for DUSP12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUSP12 gene

    Find genes that share paralogs with DUSP12           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DUSP12
    PGOHUM00000237695


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP12 (see all 206)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402209531,2
    --168268296(+) ATTGGC/TGAGCT 1 -- us2k10--------
    rs1455807781,2
    C--168268422(+) ACCCAC/TGCTTT 1 -- us2k10--------
    rs120974821,2
    F,H--168268677(+) cggtcG/Attaga 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1465057901,2
    --168268763(+) ATGAAA/GCTTTC 1 -- us2k10--------
    rs1408332061,2
    --168268964(+) CTAACA/GTATAT 1 -- us2k10--------
    rs1916792991,2
    --168269010(+) GTGACA/GTGGGT 1 -- us2k10--------
    rs1143109911,2
    C,F--168269322(+) TCCTGG/AACCAC 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs64276251,2
    C,F,A,H--168269453(+) agacaG/Cgtcga 1 -- us2k118Minor allele frequency- C:0.38NS EA NA WA CSA 1088
    rs1839582861,2
    --168269641(+) CCCCAA/GATAAA 1 -- us2k10--------
    rs64276261,2
    C,F,A,H--168269662(+) ctgtaT/Gaggat 1 -- us2k125Minor allele frequency- G:0.36NS EA NA WA CSA 2512

    HapMap Linkage Disequilibrium report for DUSP12 (161719548 - 161727028 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DUSP12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428257CNV Loss18775914
    nsv464184CNV Gain19166990
    esv33393CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604835    OMIM disorders: --


    Find genes that share disorders with DUSP12           About GenesLikeMe

    Genetic Association Database (GAD): DUSP12
    Human Genome Epidemiology (HuGE) Navigator: DUSP12 (4 documents)

    Export disorders for DUSP12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP12 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with DUSP12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function. (PubMed id 10446167)1, 2, 3, 9 Muda M.... Dixon J.E. (J. Biol. Chem. 1999)
    2. [Association of -6735T--&gt;C variant of glucokinase-associated dual-specificity phosphatase 12 gene with type 2 diabetes in Chinese]. (PubMed id 19087671)1, 4, 9 Gao F....Xiang K.S. (Zhonghua Yi Xue Za Zhi 2008)
    3. Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. (PubMed id 16936214)1, 4, 9 Das S.K....Elbein S.C. (Diabetes 2006)
    4. Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PubMed id 18269685)1, 4, 9 Hasstedt S.J....Elbein S.C. (Ann. Hum. Genet. 2008)
    5. Lack of association between genetic polymorphisms within DUSP12 - ATF6 locus and glucose metabolism related traits in a Chinese population. (PubMed id 21211013)1, 4 Hu C....Jia W. (BMC Med. Genet. 2011)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11266 HGNC: 3067 AceView: DUSP12 Ensembl:ENSG00000081721 euGenes: HUgn11266
    ECgene: DUSP12 H-InvDB: DUSP12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUSP12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DUSP12 gene:
    Search GeneIP for patents involving DUSP12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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