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Aliases for DUSP12 Gene

Aliases for DUSP12 Gene

  • Dual Specificity Phosphatase 12 2 3
  • Serine/Threonine Specific Protein Phosphatase 2 3
  • Dual Specificity Tyrosine Phosphatase YVH1 3 4
  • DUSP1 3 6
  • YVH1 3 6
  • YVH1 Protein-Tyrosine Phosphatase (S. Cerevisiae) Ortholog 2
  • YVH1 Protein-Tyrosine Phosphatase Ortholog 3
  • Dual Specificity Protein Phosphatase 12 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP12 Gene

Summaries for DUSP12 Gene

Entrez Gene Summary for DUSP12 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP12 Gene

DUSP12 (Dual Specificity Phosphatase 12) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and ERK Signaling. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity.

Gene Wiki entry for DUSP12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP12 Gene

Genomics for DUSP12 Gene

Genomic Location for DUSP12 Gene

Start:
161,749,758 bp from pter
End:
161,757,238 bp from pter
Size:
7,481 bases
Orientation:
Plus strand

Genomic View for DUSP12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP12 Gene

Regulatory Elements for DUSP12 Gene

Proteins for DUSP12 Gene

  • Protein details for DUSP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNI6-DUS12_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 12
    Protein Accession:
    Q9UNI6
    Secondary Accessions:
    • Q5VXA8

    Protein attributes for DUSP12 Gene

    Size:
    340 amino acids
    Molecular mass:
    37687 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP12 Gene

neXtProt entry for DUSP12 Gene

Proteomics data for DUSP12 Gene at MOPED

Post-translational modifications for DUSP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP12 Gene

No data available for DME Specific Peptides for DUSP12 Gene

Domains for DUSP12 Gene

Gene Families for DUSP12 Gene

HGNC:
  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

UniProtKB/Swiss-Prot:

DUS12_HUMAN
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q9UNI6
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.:
    • Q9UNI6
genes like me logo Genes that share domains with DUSP12: view

Function for DUSP12 Gene

Molecular function for DUSP12 Gene

GENATLAS Biochemistry: dual specificity phosphatase 12
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

Enzyme Numbers (IUBMB) for DUSP12 Gene

Gene Ontology (GO) - Molecular Function for DUSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0008270 zinc ion binding TAS 10446167
genes like me logo Genes that share ontologies with DUSP12: view

Phenotypes for DUSP12 Gene

GenomeRNAi human phenotypes for DUSP12:
genes like me logo Genes that share phenotypes with DUSP12: view

miRNA for DUSP12 Gene

miRTarBase miRNAs that target DUSP12

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUSP12 Gene

Localization for DUSP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP12 Gene COMPARTMENTS Subcellular localization image for DUSP12 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DUSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DUSP12: view

Pathways for DUSP12 Gene

genes like me logo Genes that share pathways with DUSP12: view

Pathways by source for DUSP12 Gene

Gene Ontology (GO) - Biological Process for DUSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10446167
GO:0006470 protein dephosphorylation IBA --
GO:0016311 dephosphorylation --
GO:0033133 positive regulation of glucokinase activity IBA --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 10446167
genes like me logo Genes that share ontologies with DUSP12: view

Compounds for DUSP12 Gene

(3) HMDB Compounds for DUSP12 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with DUSP12: view

Transcripts for DUSP12 Gene

Unigene Clusters for DUSP12 Gene

Dual specificity phosphatase 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP12 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for DUSP12 Gene

GeneLoc Exon Structure for
DUSP12
ECgene alternative splicing isoforms for
DUSP12

Expression for DUSP12 Gene

mRNA expression in normal human tissues for DUSP12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP12 Gene

SOURCE GeneReport for Unigene cluster for DUSP12 Gene Hs.416216

mRNA Expression by UniProt/SwissProt for DUSP12 Gene

Q9UNI6-DUS12_HUMAN
Tissue specificity: Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung
genes like me logo Genes that share expressions with DUSP12: view

Orthologs for DUSP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP12 36
  • 99.71 (n)
  • 100 (a)
DUSP12 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP12 36
  • 86.84 (n)
  • 82.79 (a)
DUSP12 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP12 36
  • 86.43 (n)
  • 85.55 (a)
DUSP12 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp12 36
  • 82.1 (n)
  • 83.78 (a)
Dusp12 16
Dusp12 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP12 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp12 36
  • 82.05 (n)
  • 83.14 (a)
chicken
(Gallus gallus)
Aves DUSP12 36
  • 64.5 (n)
  • 63.31 (a)
DUSP12 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP12 37
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16207 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp12 36
  • 62.33 (n)
  • 63.33 (a)
Str.2015 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4868 36
zebrafish
(Danio rerio)
Actinopterygii dusp12 36
  • 62.02 (n)
  • 62.59 (a)
dusp12 37
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002108 36
  • 45.95 (n)
  • 38.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta MKP-4 36
  • 45.3 (n)
  • 39.02 (a)
MKP-4 37
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C24F3.2 37
  • 28 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL102W 36
  • 42.38 (n)
  • 33.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YVH1 36
  • 44.71 (n)
  • 35.52 (a)
YVH1 37
  • 29 (a)
OneToOne
YVH1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17997g 36
  • 46.27 (n)
  • 35.45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18593 36
  • 49.85 (n)
  • 46.02 (a)
rice
(Oryza sativa)
Liliopsida Os12g0133700 36
  • 52.1 (n)
  • 44.09 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08158 36
  • 42.15 (n)
  • 36.06 (a)
Species with no ortholog for DUSP12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP12 Gene

ENSEMBL:
Gene Tree for DUSP12 (if available)
TreeFam:
Gene Tree for DUSP12 (if available)

Paralogs for DUSP12 Gene

Pseudogenes.org Pseudogenes for DUSP12 Gene

genes like me logo Genes that share paralogs with DUSP12: view

No data available for Paralogs for DUSP12 Gene

Variants for DUSP12 Gene

Sequence variations from dbSNP and Humsavar for DUSP12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs905593 -- 161,747,949(+) CACAT(C/T)GGCAG upstream-variant-2KB
rs953301 -- 161,749,589(-) ACCCC(C/T)AAAGT upstream-variant-2KB
rs1063178 -- 161,751,917(+) GGATA(C/T)GAAGT reference, synonymous-codon
rs1063179 -- 161,752,414(+) ACTAC(C/T)GTTTC reference, synonymous-codon
rs3767638 -- 161,757,161(-) AGTAT(C/G)TGGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DUSP12 Gene

Variant ID Type Subtype PubMed ID
nsv428257 CNV Loss 18775914
esv33393 CNV Gain+Loss 17666407
nsv464184 CNV Gain 19166990

Relevant External Links for DUSP12 Gene

HapMap Linkage Disequilibrium report
DUSP12

Disorders for DUSP12 Gene

Relevant External Links for DUSP12

Genetic Association Database (GAD)
DUSP12
Human Genome Epidemiology (HuGE) Navigator
DUSP12
genes like me logo Genes that share disorders with DUSP12: view

No data available for UniProtKB/Swiss-Prot for DUSP12 Gene

Publications for DUSP12 Gene

  1. Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function. (PMID: 10446167) Muda M. … Dixon J.E. (J. Biol. Chem. 1999) 2 3 4 23
  2. Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. (PMID: 16936214) Das S.K. … Elbein S.C. (Diabetes 2006) 3 23 49
  3. Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PMID: 18269685) Hasstedt S.J. … Elbein S.C. (Ann. Hum. Genet. 2008) 3 23 49
  4. [Association of -6735T-->C variant of glucokinase-associated dual-specificity phosphatase 12 gene with type 2 diabetes in Chinese]. (PMID: 19087671) Gao F. … Xiang K.S. (Zhonghua Yi Xue Za Zhi 2008) 3 23 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DUSP12 Gene

Sources for DUSP12 Gene

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