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Aliases for DUSP12 Gene

Aliases for DUSP12 Gene

  • Dual Specificity Phosphatase 12 2 3 5
  • Serine/Threonine Specific Protein Phosphatase 2 3
  • Dual Specificity Tyrosine Phosphatase YVH1 3 4
  • YVH1 Protein-Tyrosine Phosphatase (S. Cerevisiae) Ortholog 2
  • YVH1 Protein-Tyrosine Phosphatase Ortholog 3
  • EC 4
  • EC 4
  • DUSP1 3
  • YVH1 3

External Ids for DUSP12 Gene

Previous GeneCards Identifiers for DUSP12 Gene

  • GC01P159354
  • GC01P157370
  • GC01P158415
  • GC01P158906
  • GC01P158451
  • GC01P159989
  • GC01P161719
  • GC01P132964

Summaries for DUSP12 Gene

Entrez Gene Summary for DUSP12 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP12 Gene

DUSP12 (Dual Specificity Phosphatase 12) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and kinase binding.

Gene Wiki entry for DUSP12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP12 Gene

Genomics for DUSP12 Gene

Regulatory Elements for DUSP12 Gene

Enhancers for DUSP12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DUSP12 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP12 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP12 Gene

161,749,758 bp from pter
161,757,238 bp from pter
7,481 bases
Plus strand

Genomic View for DUSP12 Gene

Genes around DUSP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP12 Gene

Proteins for DUSP12 Gene

  • Protein details for DUSP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 12
    Protein Accession:
    Secondary Accessions:
    • Q5VXA8

    Protein attributes for DUSP12 Gene

    340 amino acids
    Molecular mass:
    37687 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP12 Gene

neXtProt entry for DUSP12 Gene

Proteomics data for DUSP12 Gene at MOPED

Post-translational modifications for DUSP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP12 Gene

Antibody Products

No data available for DME Specific Peptides for DUSP12 Gene

Domains & Families for DUSP12 Gene

Gene Families for DUSP12 Gene

Suggested Antigen Peptide Sequences for DUSP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP12: view

Function for DUSP12 Gene

Molecular function for DUSP12 Gene

GENATLAS Biochemistry:
dual specificity phosphatase 12
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for DUSP12 Gene

Gene Ontology (GO) - Molecular Function for DUSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016791 phosphatase activity IEA --
GO:0019900 kinase binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DUSP12: view
genes like me logo Genes that share phenotypes with DUSP12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP12

miRNA for DUSP12 Gene

miRTarBase miRNAs that target DUSP12

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP12 Gene

Localization for DUSP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP12 Gene

Subcellular locations from

Jensen Localization Image for DUSP12 Gene COMPARTMENTS Subcellular localization image for DUSP12 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DUSP12 Gene

Pathways & Interactions for DUSP12 Gene

SuperPathways for DUSP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033133 positive regulation of glucokinase activity IEA,IBA --
genes like me logo Genes that share ontologies with DUSP12: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP12 Gene

Drugs & Compounds for DUSP12 Gene

(1) Drugs for DUSP12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(3) Additional Compounds for DUSP12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DUSP12: view

Transcripts for DUSP12 Gene

Unigene Clusters for DUSP12 Gene

Dual specificity phosphatase 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP12 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for DUSP12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP12 Gene

mRNA expression in normal human tissues for DUSP12 Gene

Protein differential expression in normal tissues from HIPED for DUSP12 Gene

This gene is overexpressed in Lung (51.3) and Breast (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP12 Gene

SOURCE GeneReport for Unigene cluster for DUSP12 Gene Hs.416216

mRNA Expression by UniProt/SwissProt for DUSP12 Gene

Tissue specificity: Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung.
genes like me logo Genes that share expression patterns with DUSP12: view

Protein tissue co-expression partners for DUSP12 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DUSP12 Gene

Orthologs for DUSP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUSP12 35
  • 86.84 (n)
  • 82.79 (a)
DUSP12 36
  • 81 (a)
(Canis familiaris)
Mammalia DUSP12 35
  • 86.43 (n)
  • 85.55 (a)
DUSP12 36
  • 83 (a)
(Mus musculus)
Mammalia Dusp12 35
  • 82.1 (n)
  • 83.78 (a)
Dusp12 16
Dusp12 36
  • 84 (a)
(Pan troglodytes)
Mammalia DUSP12 35
  • 99.71 (n)
  • 100 (a)
DUSP12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dusp12 35
  • 82.05 (n)
  • 83.14 (a)
(Monodelphis domestica)
Mammalia DUSP12 36
  • 77 (a)
(Gallus gallus)
Aves DUSP12 35
  • 64.5 (n)
  • 63.31 (a)
DUSP12 36
  • 60 (a)
(Anolis carolinensis)
Reptilia DUSP12 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp12 35
  • 62.33 (n)
  • 63.33 (a)
Str.2015 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16207 35
(Danio rerio)
Actinopterygii dusp12 35
  • 62.02 (n)
  • 62.59 (a)
dusp12 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4868 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002108 35
  • 45.95 (n)
  • 38.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta MKP-4 35
  • 45.3 (n)
  • 39.02 (a)
MKP-4 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea C24F3.2 36
  • 28 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL102W 35
  • 42.38 (n)
  • 33.33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17997g 35
  • 46.27 (n)
  • 35.45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YVH1 35
  • 44.71 (n)
  • 35.52 (a)
YVH1 36
  • 29 (a)
YVH1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18593 35
  • 49.85 (n)
  • 46.02 (a)
(Oryza sativa)
Liliopsida Os12g0133700 35
  • 52.1 (n)
  • 44.09 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08158 35
  • 42.15 (n)
  • 36.06 (a)
Species with no ortholog for DUSP12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP12 Gene

Gene Tree for DUSP12 (if available)
Gene Tree for DUSP12 (if available)

Paralogs for DUSP12 Gene Pseudogenes for DUSP12 Gene

genes like me logo Genes that share paralogs with DUSP12: view

No data available for Paralogs for DUSP12 Gene

Variants for DUSP12 Gene

Sequence variations from dbSNP and Humsavar for DUSP12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35106830 - 161,749,953(+) GGAAG(A/C)GGGCA reference, missense, utr-variant-5-prime
rs905593 -- 161,747,949(+) CACAT(C/T)GGCAG upstream-variant-2KB
rs953301 -- 161,749,589(-) ACCCC(C/T)AAAGT upstream-variant-2KB
rs1063178 -- 161,751,917(+) GGATA(C/T)GAAGT reference, synonymous-codon
rs1063179 -- 161,752,414(+) ACTAC(C/T)GTTTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DUSP12 Gene

Variant ID Type Subtype PubMed ID
nsv428257 CNV Loss 18775914
esv33393 CNV Gain+Loss 17666407
nsv464184 CNV Gain 19166990

Variation tolerance for DUSP12 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DUSP12 Gene

Disorders for DUSP12 Gene

Relevant External Links for DUSP12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DUSP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP12 Gene

Publications for DUSP12 Gene

  1. Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function. (PMID: 10446167) Muda M. … Dixon J.E. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PMID: 18269685) Hasstedt S.J. … Elbein S.C. (Ann. Hum. Genet. 2008) 3 23
  3. [Association of -6735T-->C variant of glucokinase-associated dual-specificity phosphatase 12 gene with type 2 diabetes in Chinese]. (PMID: 19087671) Gao F. … Xiang K.S. (Zhonghua Yi Xue Za Zhi 2008) 3 23
  4. Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. (PMID: 16936214) Das S.K. … Elbein S.C. (Diabetes 2006) 3 23
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for DUSP12 Gene

Sources for DUSP12 Gene