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Aliases for DUSP12 Gene

Aliases for DUSP12 Gene

  • Dual Specificity Phosphatase 12 2 3 5
  • Serine/Threonine Specific Protein Phosphatase 2 3
  • Dual Specificity Tyrosine Phosphatase YVH1 3 4
  • YVH1 Protein-Tyrosine Phosphatase (S. Cerevisiae) Ortholog 2
  • YVH1 Protein-Tyrosine Phosphatase Ortholog 3
  • Dual Specificity Protein Phosphatase 12 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP1 3
  • YVH1 3

External Ids for DUSP12 Gene

Previous GeneCards Identifiers for DUSP12 Gene

  • GC01P159354
  • GC01P157370
  • GC01P158415
  • GC01P158906
  • GC01P158451
  • GC01P159989
  • GC01P161719
  • GC01P132964

Summaries for DUSP12 Gene

Entrez Gene Summary for DUSP12 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP12 Gene

DUSP12 (Dual Specificity Phosphatase 12) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and kinase binding. An important paralog of this gene is DUSP27.

UniProtKB/Swiss-Prot for DUSP12 Gene

  • Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476).

Gene Wiki entry for DUSP12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP12 Gene

Genomics for DUSP12 Gene

Regulatory Elements for DUSP12 Gene

Enhancers for DUSP12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G161096 1.2 ENCODE 126.6 -652.1 -652080 2.9 AGO1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 SP3 MCM3 TBX21 DUSP12 RPSAP18 ENSG00000228606 KLHDC9 ATF6 FCER1G NDUFS2 B4GALT3 NIT1 NECTIN4
GH01G161127 1.1 Ensembl 88.6 -622.0 -621958 0.8 HDGF ARNT SIN3A FEZF1 YBX1 ZNF2 YY1 ZNF302 ZNF416 ZNF548 DUSP12 RPSAP18 ENSG00000228606 ATF6 KLHDC9 B4GALT3 PIR61783 DEDD
GH01G161158 1.2 ENCODE 75.7 -589.3 -589261 4.9 AGO1 DMAP1 YBX1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 DUSP12 ENSG00000228606 RPSAP18 ATF6 NIT1 TSTD1 USP21 PPOX
GH01G161130 1.2 ENCODE 74.4 -617.4 -617378 3.9 CREB3L1 FEZF1 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 DUSP12 ENSG00000228606 ATF6 RPSAP18 B4GALT3 DEDD PIR61783
GH01G162700 1 dbSUPER 56.3 +954.2 954192 6.1 GLI4 TCF12 GATA2 FOS YY2 JUNB ZNF488 TSHZ1 ZNF662 MEF2D DUSP12 DDR2 RN7SL861P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUSP12 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014740 342 1401 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5

Genomic Location for DUSP12 Gene

Chromosome:
1
Start:
161,749,758 bp from pter
End:
161,757,238 bp from pter
Size:
7,481 bases
Orientation:
Plus strand

Genomic View for DUSP12 Gene

Genes around DUSP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP12 Gene

Proteins for DUSP12 Gene

  • Protein details for DUSP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNI6-DUS12_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 12
    Protein Accession:
    Q9UNI6
    Secondary Accessions:
    • Q5VXA8

    Protein attributes for DUSP12 Gene

    Size:
    340 amino acids
    Molecular mass:
    37687 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DUSP12 Gene

neXtProt entry for DUSP12 Gene

Post-translational modifications for DUSP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP12 Gene

No data available for DME Specific Peptides for DUSP12 Gene

Domains & Families for DUSP12 Gene

Gene Families for DUSP12 Gene

Suggested Antigen Peptide Sequences for DUSP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNI6

UniProtKB/Swiss-Prot:

DUS12_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP12: view

Function for DUSP12 Gene

Molecular function for DUSP12 Gene

GENATLAS Biochemistry:
dual specificity phosphatase 12
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476).

Enzyme Numbers (IUBMB) for DUSP12 Gene

Gene Ontology (GO) - Molecular Function for DUSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,TAS --
GO:0005515 protein binding IPI 16189514
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0008270 zinc ion binding IDA 10446167
genes like me logo Genes that share ontologies with DUSP12: view
genes like me logo Genes that share phenotypes with DUSP12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP12

CRISPR Products

miRNA for DUSP12 Gene

miRTarBase miRNAs that target DUSP12

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP12 Gene

Localization for DUSP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP12 Gene

Nucleus. Cytoplasm, cytosol. Note=Primarily nuclear. Detected in a mesh-like pattern in the cytosol. {ECO:0000269 PubMed:10446167}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP12 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DUSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10446167
GO:0005737 cytoplasm IDA,IEA 10446167
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with DUSP12: view

Pathways & Interactions for DUSP12 Gene

SuperPathways for DUSP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10446167
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IDA 10446167
GO:0033133 positive regulation of glucokinase activity IEA,IBA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP12: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP12 Gene

Drugs & Compounds for DUSP12 Gene

(3) Drugs for DUSP12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0

(1) Additional Compounds for DUSP12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with DUSP12: view

Transcripts for DUSP12 Gene

Unigene Clusters for DUSP12 Gene

Dual specificity phosphatase 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP12 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for DUSP12 Gene

GeneLoc Exon Structure for
DUSP12
ECgene alternative splicing isoforms for
DUSP12

Expression for DUSP12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP12 Gene

Protein differential expression in normal tissues from HIPED for DUSP12 Gene

This gene is overexpressed in Lung (51.3) and Breast (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUSP12 Gene



Protein tissue co-expression partners for DUSP12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUSP12 Gene:

DUSP12

SOURCE GeneReport for Unigene cluster for DUSP12 Gene:

Hs.416216

mRNA Expression by UniProt/SwissProt for DUSP12 Gene:

Q9UNI6-DUS12_HUMAN
Tissue specificity: Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung.
genes like me logo Genes that share expression patterns with DUSP12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP12 Gene

Orthologs for DUSP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP12 34 35
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia DUSP12 34 35
  • 86.84 (n)
dog
(Canis familiaris)
Mammalia DUSP12 34 35
  • 86.43 (n)
mouse
(Mus musculus)
Mammalia Dusp12 34 16 35
  • 82.1 (n)
rat
(Rattus norvegicus)
Mammalia Dusp12 34
  • 82.05 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP12 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP12 34 35
  • 64.5 (n)
lizard
(Anolis carolinensis)
Reptilia DUSP12 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp12 34
  • 62.33 (n)
Str.2015 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16207 34
zebrafish
(Danio rerio)
Actinopterygii dusp12 34 35
  • 62.02 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4868 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002108 34
  • 45.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta MKP-4 34 35
  • 45.3 (n)
worm
(Caenorhabditis elegans)
Secernentea C24F3.2 35
  • 28 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17997g 34
  • 46.27 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YVH1 34 35 37
  • 44.71 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL102W 34
  • 42.38 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18593 34
  • 49.85 (n)
rice
(Oryza sativa)
Liliopsida Os12g0133700 34
  • 52.1 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08158 34
  • 42.15 (n)
Species where no ortholog for DUSP12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP12 Gene

ENSEMBL:
Gene Tree for DUSP12 (if available)
TreeFam:
Gene Tree for DUSP12 (if available)

Paralogs for DUSP12 Gene

Pseudogenes.org Pseudogenes for DUSP12 Gene

genes like me logo Genes that share paralogs with DUSP12: view

Variants for DUSP12 Gene

Sequence variations from dbSNP and Humsavar for DUSP12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000018263 -- 161,749,678(+) CCTGC(-/G)GCCGA upstream-variant-2KB
rs1000187820 -- 161,748,865(+) CTTTT(G/T)CTTCC upstream-variant-2KB
rs1001347210 -- 161,749,550(+) AGAAA(A/C)CCTGT upstream-variant-2KB
rs1001502933 -- 161,755,627(+) ATTTA(C/T)TGTTT intron-variant
rs1001743802 -- 161,751,177(+) TTACG(C/G)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP12 Gene

Variant ID Type Subtype PubMed ID
esv33393 CNV gain+loss 17666407
esv3445971 CNV insertion 20981092
nsv428257 CNV loss 18775914
nsv464184 CNV gain 19166990
nsv548075 CNV gain 21841781

Variation tolerance for DUSP12 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP12 Gene

Disorders for DUSP12 Gene

Relevant External Links for DUSP12

Genetic Association Database (GAD)
DUSP12
Human Genome Epidemiology (HuGE) Navigator
DUSP12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP12

No disorders were found for DUSP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP12 Gene

Publications for DUSP12 Gene

  1. Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function. (PMID: 10446167) Muda M. … Dixon J.E. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PMID: 18269685) Hasstedt S.J. … Elbein S.C. (Ann. Hum. Genet. 2008) 3 22 46 64
  3. [Association of -6735T-->C variant of glucokinase-associated dual-specificity phosphatase 12 gene with type 2 diabetes in Chinese]. (PMID: 19087671) Gao F. … Xiang K.S. (Zhonghua Yi Xue Za Zhi 2008) 3 22 46 64
  4. Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. (PMID: 16936214) Das S.K. … Elbein S.C. (Diabetes 2006) 3 22 46 64
  5. The family-wide structure and function of human dual-specificity protein phosphatases. (PMID: 24531476) Jeong D.G. … Ryu S.E. (Acta Crystallogr. D 2014) 3 4 64

Products for DUSP12 Gene

Sources for DUSP12 Gene

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