DUSP12 Gene
protein-coding GIFtS: 55
GCID: GC01P161719
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|
dual specificity phosphatase 12
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Aliases for DUSP12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Dual Specificity Phosphatase 121 2 | | Serine/Threonine Specific Protein Phosphatase2 | | DUSP11 2 5 | | YVH1 Protein-Tyrosine Phosphatase Ortholog2 | | YVH11 2 5 | | EC 3.1.3.163 | | Dual Specificity Tyrosine Phosphatase YVH12 3 | | EC 3.1.3.483 | | Dual Specificity Protein Phosphatase 122 | | |
Export aliases for DUSP12 gene to outside databasesPrevious GC identifers: GC01P159354 GC01P157370 GC01P158415 GC01P158906 GC01P158451 GC01P159989 GC01P132964 |
Summaries for DUSP12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for DUSP12: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatasesinactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38),which is associated with cellular proliferation and differentiation. Different members of the family of dualspecificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distributionand subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. Thisgene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localizedpredominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. (provided byRefSeq, Jul 2008) Gene Wiki entry for DUSP12
|
Genomic Views for DUSP12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DUSP12 gene promoter: STAT1 AML1a STAT4 STAT1beta STAT1alpha CREB deltaCREB STAT2 STAT3 ATF6 Other transcription factors
Search SABiosciences Chromatin IP Primers for DUSP12
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP12 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21-q22 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q21-q22DUSP12 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P161719: view genomic region
(about GC identifiers)
Start:
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161,719,548 bp from pter |
End:
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161,727,028 bp from pter |
Size:
|
7,481 bases |
Orientation:
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plus strand |
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Proteins for DUSP12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DUS12_HUMAN, Q9UNI6 (See
protein sequence)Recommended Name: Dual specificity protein phosphatase 12 Size: 340 amino acids; 37687 Da
Cofactor: Binds 2 zinc ions per subunit
Subcellular location: Nucleus
Secondary accessions: Q5VXA8Explore the universe of human proteins at neXtProt for DUSP12: NX_Q9UNI6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UNI6 DUSP12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009171.1 ENSEMBL proteins: ENSP00000356920 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
DUSP12 for ontologies About GeneDecksing
DUSP12 Antibody Products: Assay Products for DUSP12: |
Protein
Domains / Families for DUSP12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DUSP12 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9UNI6ProtoNet protein and cluster: Q9UNI6 1 Blocks protein family: IPB000340 Dual specificity protein phosphatase
UniProtKB/Swiss-Prot: DUS12_HUMAN, Q9UNI6Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamilySimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function for DUSP12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: DUS12_HUMAN, Q9UNI6Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphate Genatlas biochemistry entry for DUSP12:dual specificity phosphatase 12 Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP12 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DUSP12 (NM_007240) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUSP12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP12  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP12 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004721 | phosphoprotein phosphatase activity |
-- | -- | | GO:0004725 | protein tyrosine phosphatase activity |
IEA | -- | | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
IBA | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0019900 | kinase binding |
IEA | -- |
DUSP12 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DUSP12:
|
Pathways & Interactions for DUSP12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
 5/40 Interacting proteins for DUSP12 (Q9UNI62, 3 ENSP000003569204) via UniProtKB, MINT, STRING, and/or I2D (see all 40)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
DUSP12 for ontologies About GeneDecksing
|
Drugs & Compounds for DUSP12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for DUSP12
3 HMDB Compounds for DUSP12 About this table Search CenterWatch for drugs/clinical trials and news about DUSP12 / DUS12 
|
Transcripts for DUSP12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DUSP12 gene: NM_007240.1 Unigene Cluster for DUSP12: Dual specificity phosphatase 12 Hs.416216 [show with all ESTs]Unigene Representative Sequence: BC0062865 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000484291 ENST00000367943(uc001gbo.3) ENST00000464004 ENST00000490591 ENST00000463365
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP12 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DUSP12 (NM_007240) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUSP12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP12  |
Additional cDNA sequence: AF119226.1 AK000259.1 BC006286.1 BT006633.1 6 DOTS entries: DT.86839113 DT.441722 DT.91743497 DT.100678121 DT.100779348 DT.100839118 24/161 AceView cDNA sequences (see all 161): CR599391 BQ423889 CB146889 AK000259 BM714291 CB852566 AL047655 AA374202 CB159708 AA031672 AA927984 CB240728 BM709742 AA464391 BM474343 BU622998 BU731552 BI712932 BM782644 CR611136 CA776245 BM807904 AA485951 AA147450 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP12 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for DUSP12
|
Expression for DUSP12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUSP12 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TACATTTTAT
About this image See DUSP12 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DUSP12
SOURCE GeneReport for Unigene cluster: Hs.416216 UniProtKB/Swiss-Prot: DUS12_HUMAN, Q9UNI6Tissue specificity: Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lowerexpression in liver and lung SABiosciences Expression via Pathway-Focused PCR Array including DUSP12:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP12 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP12 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP12 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP12 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP12 |
Orthologs for DUSP12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DUSP12 gene from 10/31 species (see all 31) About this table
ENSEMBL Gene Tree for DUSP12 (if available) TreeFam Gene Tree for DUSP12 (if available)  |
Paralogs for DUSP12 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for DUSP12 gene
- DUSP152 DUSP222 STYX2
DUSP12 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DUSP12 PGOHUM00000237695
|
Genomic Variants for DUSP12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for DUSP12 (161719548 - 161727028 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for DUSP12 1 CNV: 6791  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP12 |
|
Disorders
/ Diseases for DUSP12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DUSP12 for disorders About GeneDecksing
OMIM gene information: 604835
OMIM disorders: --
2 diseases for DUSP12: About MalaCardssarcoma malaria Human Genome Epidemiology (HuGE) Navigator: DUSP12 (4 documents) Export disorders for DUSP12 gene to outside databases
|
Publications for DUSP12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DUSP12 gene, integrated from 9 sources (see all 21): (articles sorted by number of sources associating them with DUSP12) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function. (PubMed id 10446167)1, 2, 3, 9 Muda M.... Dixon J.E. (1999)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- [Association of -6735T-->C variant of glucokinase-associated dual-specificity phosphatase 12 gene with type 2 diabetes in Chinese] (PubMed id 19087671)1, 9 Gao F....Xiang K.S. (2008)
- Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. (PubMed id 16936214)1, 9 Das S.K....Elbein S.C. (2006)
- Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PubMed id 18269685)1, 9 Hasstedt S.J....Elbein S.C. (2008)
- Lack of association between genetic polymorphisms wit hin DUSP12 - ATF6 locus and glucose metabolism related traits in a Chinese popu lation. (PubMed id 21211013)1 Hu C....Jia W. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- The dual-specificity phosphatase hYVH1 (DUSP12) is a novel modulator of cellular DNA content. (PubMed id 21521943)1 Kozarova A....Vacratsis P.O. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
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External Searches for DUSP12 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DUSP12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DUSP12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DUSP12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for DUSP12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DUSP12 gene: Search GeneIP for patents involving DUSP12
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for DUSP12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | OriGene Custom Antibody Services for DUSP12 | | OriGene Custom Protein Services for DUSP12 | | OriGene Custom Immunoassay Development | | |
| |  |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUSP12 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP12 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP12 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP12 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP12 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP12 |
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| | | Search Tocris compounds for DUSP12 |
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 | | DUSP12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP12 |
|  |  |  | | | ThermoFisher Antibodies for DUSP12 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP12 |
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