Aliases for DUSP11 Gene
External Ids for DUSP11 Gene
Previous GeneCards Identifiers for DUSP11 Gene
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
GeneCards Summary for DUSP11 Gene
DUSP11 (Dual Specificity Phosphatase 11 (RNA/RNP Complex 1-Interacting)) is a Protein Coding gene. Diseases associated with DUSP11 include amyotrophic lateral sclerosis 1. GO annotations related to this gene include poly(A) RNA binding and phosphatase activity. An important paralog of this gene is RNGTT.
UniProtKB/Swiss-Prot for DUSP11 Gene
Possesses RNA 5-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.