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Aliases for DUSP11 Gene

Aliases for DUSP11 Gene

  • Dual Specificity Phosphatase 11 (RNA/RNP Complex 1-Interacting) 2 3
  • PIR1 3 4 6
  • Phosphatase That Interacts With RNA/RNP Complex 1 3 4
  • Dual Specificity Protein Phosphatase 11 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • RNA/RNP Complex-1-Interacting Phosphatase 3
  • RNA/RNP Complex-Interacting Phosphatase 3
  • EC 3.1.3.- 4

External Ids for DUSP11 Gene

Summaries for DUSP11 Gene

Entrez Gene Summary for DUSP11 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

GeneCards Summary for DUSP11 Gene

DUSP11 (Dual Specificity Phosphatase 11 (RNA/RNP Complex 1-Interacting)) is a Protein Coding gene. GO annotations related to this gene include RNA binding and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is RNGTT.

UniProtKB/Swiss-Prot for DUSP11 Gene

  • Possesses RNA 5-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP11 Gene

Genomics for DUSP11 Gene

Genomic Location for DUSP11 Gene

Start:
73,762,184 bp from pter
End:
73,780,157 bp from pter
Size:
17,974 bases
Orientation:
Minus strand

Genomic View for DUSP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP11 Gene

Regulatory Elements for DUSP11 Gene

Proteins for DUSP11 Gene

  • Protein details for DUSP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75319-DUS11_HUMAN
    Recommended name:
    RNA/RNP complex-1-interacting phosphatase
    Protein Accession:
    O75319
    Secondary Accessions:
    • B2RCT8
    • Q6AI47
    • Q9BWE3

    Protein attributes for DUSP11 Gene

    Size:
    330 amino acids
    Molecular mass:
    38939 Da
    Quaternary structure:
    • May interact with SFRS7 and SFRS9/SRP30C.
    SequenceCaution:
    • Sequence=CAH10467.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUSP11 Gene

    Alternative splice isoforms for DUSP11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP11 Gene

Proteomics data for DUSP11 Gene at MOPED

Post-translational modifications for DUSP11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys64 and Lys231

Other Protein References for DUSP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP11 Gene

Domains for DUSP11 Gene

Gene Families for DUSP11 Gene

HGNC:
  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

UniProtKB/Swiss-Prot:

DUS11_HUMAN
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.:
    • O75319
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.:
    • O75319
genes like me logo Genes that share domains with DUSP11: view

Function for DUSP11 Gene

Molecular function for DUSP11 Gene

UniProtKB/Swiss-Prot Function: Possesses RNA 5-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.

Enzyme Numbers (IUBMB) for DUSP11 Gene

Gene Ontology (GO) - Molecular Function for DUSP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9685386
GO:0004651 polynucleotide 5-phosphatase activity IDA 10347225
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016791 phosphatase activity IDA 24447265
genes like me logo Genes that share ontologies with DUSP11: view

Phenotypes for DUSP11 Gene

GenomeRNAi human phenotypes for DUSP11:
genes like me logo Genes that share phenotypes with DUSP11: view

miRNA for DUSP11 Gene

miRTarBase miRNAs that target DUSP11

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUSP11 Gene

Localization for DUSP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP11 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP11 Gene COMPARTMENTS Subcellular localization image for DUSP11 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DUSP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9685386
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with DUSP11: view

Pathways for DUSP11 Gene

SuperPathways for DUSP11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 9685386
GO:0006470 protein dephosphorylation --
GO:0016070 RNA metabolic process IDA 10347225
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 9685386
genes like me logo Genes that share ontologies with DUSP11: view

No data available for Pathways by source for DUSP11 Gene

Transcripts for DUSP11 Gene

Unigene Clusters for DUSP11 Gene

Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2:
SP3: - -
SP4: - -

Relevant External Links for DUSP11 Gene

GeneLoc Exon Structure for
DUSP11
ECgene alternative splicing isoforms for
DUSP11

Expression for DUSP11 Gene

mRNA expression in normal human tissues for DUSP11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP11 Gene

SOURCE GeneReport for Unigene cluster for DUSP11 Gene Hs.14611

genes like me logo Genes that share expressions with DUSP11: view

Orthologs for DUSP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP11 36
  • 99.56 (n)
  • 98.94 (a)
DUSP11 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP11 37
  • 75 (a)
OneToOne
LOC786531 36
  • 85.01 (n)
  • 76.9 (a)
dog
(Canis familiaris)
Mammalia DUSP11 36
  • 87.03 (n)
  • 79.64 (a)
DUSP11 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp11 36
  • 79.83 (n)
  • 71.66 (a)
Dusp11 16
Dusp11 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP11 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP11 37
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911499 36
  • 78.05 (n)
  • 70.19 (a)
chicken
(Gallus gallus)
Aves DUSP11 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP11 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32481 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20492 36
zebrafish
(Danio rerio)
Actinopterygii dusp11 36
  • 62.36 (n)
  • 63.27 (a)
dusp11 37
  • 40 (a)
OneToOne
wufa05e01 36
fruit fly
(Drosophila melanogaster)
Insecta CG13197 37
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F54C8.4 37
  • 21 (a)
OneToMany
pir-1 36
  • 51.75 (n)
  • 42.86 (a)
pir-1 37
  • 35 (a)
OneToMany
T23G7.5 38
  • 42 (a)
F54C8.4 38
  • 38 (a)
Species with no ortholog for DUSP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP11 Gene

ENSEMBL:
Gene Tree for DUSP11 (if available)
TreeFam:
Gene Tree for DUSP11 (if available)

Paralogs for DUSP11 Gene

Paralogs for DUSP11 Gene

genes like me logo Genes that share paralogs with DUSP11: view

Variants for DUSP11 Gene

Sequence variations from dbSNP and Humsavar for DUSP11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1802053 -- 73,762,462(-) TCTGT(C/T)ATTCC utr-variant-3-prime, downstream-variant-500B
rs1802054 -- 73,774,929(-) TCAAC(G/T)CTATT reference, missense, nc-transcript-variant
rs2116367 -- 73,773,574(+) TGAGC(C/T)AGTTC intron-variant
rs2272051 -- 73,780,009(-) GGCCG(A/G)CTTGG reference, missense, nc-transcript-variant
rs2421559 -- 73,772,527(+) AAAAT(A/G)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP11 Gene

Variant ID Type Subtype PubMed ID
dgv1197e1 CNV Complex 17122850
essv105 CNV CNV 17122850
nsv834260 CNV Gain 17160897
nsv511053 CNV Complex 20534489
nsv2780 CNV Loss 18451855
nsv508842 CNV Insertion 20534489

Relevant External Links for DUSP11 Gene

HapMap Linkage Disequilibrium report
DUSP11

Disorders for DUSP11 Gene

No disorders were found for DUSP11 Gene.

No data available for UniProtKB/Swiss-Prot for DUSP11 Gene

Publications for DUSP11 Gene

  1. PIR1, a novel phosphatase that exhibits high affinity to RNA ribonucleoprotein complexes. (PMID: 9685386) Yuan Y. … Sun H. (J. Biol. Chem. 1998) 2 3 4
  2. Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activities. (PMID: 10347225) Deshpande T. … Charbonneau H. (J. Biol. Chem. 1999) 3 4
  3. Structure of human PIR1, an atypical dual-specificity phosphatase. (PMID: 24447265) Sankhala R.S. … Cingolani G. (Biochemistry 2014) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Isolation and characterization of DUSP11, a novel p53 target gene. (PMID: 19120688) Caprara G. … Helin K. (J. Cell. Mol. Med. 2009) 3 23

Products for DUSP11 Gene

Sources for DUSP11 Gene

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