Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DUSP11 Gene

Aliases for DUSP11 Gene

  • Dual Specificity Phosphatase 11 2 3 5
  • Phosphatase That Interacts With RNA/RNP Complex 1 3 4
  • Dual Specificity Protein Phosphatase 11 3 4
  • RNA/RNP Complex 1-Interacting 2 3
  • PIR1 3 4
  • Dual Specificity Phosphatase 11 (RNA/RNP Complex 1-Interacting) 2
  • Serine/Threonine Specific Protein Phosphatase 3
  • RNA/RNP Complex-1-Interacting Phosphatase 3
  • RNA/RNP Complex-Interacting Phosphatase 3
  • EC 3.1.3.- 4

External Ids for DUSP11 Gene

Previous GeneCards Identifiers for DUSP11 Gene

  • GC02M073998
  • GC02M074200
  • GC02M073963
  • GC02M073900
  • GC02M073989
  • GC02M073723

Summaries for DUSP11 Gene

Entrez Gene Summary for DUSP11 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

GeneCards Summary for DUSP11 Gene

DUSP11 (Dual Specificity Phosphatase 11) is a Protein Coding gene. Diseases associated with DUSP11 include Amyotrophic Lateral Sclerosis 1. Gene Ontology (GO) annotations related to this gene include phosphatase activity. An important paralog of this gene is RNGTT.

UniProtKB/Swiss-Prot for DUSP11 Gene

  • Possesses RNA 5-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.

Additional gene information for DUSP11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP11 Gene

Genomics for DUSP11 Gene

GeneHancer (GH) Regulatory Elements for DUSP11 Gene

Promoters and enhancers for DUSP11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I073778 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563 +0.4 375 2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 DUSP11 ENSG00000273245 TPRKB TTC31 PCGF1 ENSG00000280037
GH02I073232 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 64.7 +545.8 545824 3.9 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 NFYC CCT7 PRADC1 DUSP11 ENSG00000273245 MOB1A FBXO41 TPRKB ALMS1 DGUOK-AS1 PIR47890
GH02I074196 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 38.6 -418.6 -418590 3.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ENSG00000279070 MTHFD2 PCGF1 DUSP11 INO80B ENSG00000273245 WBP1 AUP1 TTC31 MOB1A
GH02I073069 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.9 +709.2 709218 3.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 SFXN5 DUSP11 CCT7 ENSG00000273245 ALMS1 TPRKB SMYD5 DGUOK-AS1 RAB11FIP5 GC02M073119
GH02I073109 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.8 +668.3 668262 5.2 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 FOS SP3 RAB11FIP5 ENSG00000272702 DUSP11 ENSG00000273245 SFXN5 EMX1 SPR SMYD5 PIR41361 GC02M073116
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DUSP11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP11 gene promoter:

Genomic Locations for DUSP11 Gene

Genomic Locations for DUSP11 Gene
chr2:73,762,184-73,780,157
(GRCh38/hg38)
Size:
17,974 bases
Orientation:
Minus strand
chr2:73,989,311-74,007,284
(GRCh37/hg19)

Genomic View for DUSP11 Gene

Genes around DUSP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP11 Gene

Proteins for DUSP11 Gene

  • Protein details for DUSP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75319-DUS11_HUMAN
    Recommended name:
    RNA/RNP complex-1-interacting phosphatase
    Protein Accession:
    O75319
    Secondary Accessions:
    • B2RCT8
    • Q6AI47
    • Q9BWE3

    Protein attributes for DUSP11 Gene

    Size:
    330 amino acids
    Molecular mass:
    38939 Da
    Quaternary structure:
    • Monomer (PubMed:24531476). May interact with SFRS7 and SFRS9/SRP30C (PubMed:24447265).
    SequenceCaution:
    • Sequence=CAH10467.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUSP11 Gene

    Alternative splice isoforms for DUSP11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP11 Gene

Post-translational modifications for DUSP11 Gene

  • Ubiquitination at posLast=6464 and Lys231

Other Protein References for DUSP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP11 Gene

Domains & Families for DUSP11 Gene

Gene Families for DUSP11 Gene

Suggested Antigen Peptide Sequences for DUSP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75319

UniProtKB/Swiss-Prot:

DUS11_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP11: view

Function for DUSP11 Gene

Molecular function for DUSP11 Gene

UniProtKB/Swiss-Prot Function:
Possesses RNA 5-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.

Enzyme Numbers (IUBMB) for DUSP11 Gene

Gene Ontology (GO) - Molecular Function for DUSP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IDA 9685386
GO:0004651 polynucleotide 5-phosphatase activity IDA 10347225
GO:0004725 protein tyrosine phosphatase activity IEA,IDA 9685386
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUSP11: view
genes like me logo Genes that share phenotypes with DUSP11: view

Animal Models for DUSP11 Gene

MGI Knock Outs for DUSP11:

Animal Model Products

CRISPR Products

miRNA for DUSP11 Gene

miRTarBase miRNAs that target DUSP11

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP11 Gene

Localization for DUSP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP11 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP11 gene
Compartment Confidence
nucleus 5
extracellular 4
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Cytokinetic bridge (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0016607 nuclear speck IEA,IDA 9685386
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with DUSP11: view

Pathways & Interactions for DUSP11 Gene

SuperPathways for DUSP11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 9685386
GO:0006470 protein dephosphorylation IEA,IDA 9685386
GO:0016070 RNA metabolic process IDA 10347225
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP11: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP11 Gene

Drugs & Compounds for DUSP11 Gene

No Compound Related Data Available

Transcripts for DUSP11 Gene

Unigene Clusters for DUSP11 Gene

Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2:
SP3: - -
SP4: - -

Relevant External Links for DUSP11 Gene

GeneLoc Exon Structure for
DUSP11
ECgene alternative splicing isoforms for
DUSP11

Expression for DUSP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP11 Gene

Protein differential expression in normal tissues from HIPED for DUSP11 Gene

This gene is overexpressed in Adipocyte (19.6), CD8 Tcells (17.1), Fetal ovary (10.9), Placenta (6.9), and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUSP11 Gene



Protein tissue co-expression partners for DUSP11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUSP11 Gene:

DUSP11

SOURCE GeneReport for Unigene cluster for DUSP11 Gene:

Hs.14611

Evidence on tissue expression from TISSUES for DUSP11 Gene

  • Nervous system(4.5)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with DUSP11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP11 Gene

Orthologs for DUSP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP11 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia DUSP11 33 34
  • 87.03 (n)
cow
(Bos Taurus)
Mammalia LOC786531 33
  • 85.01 (n)
DUSP11 34
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp11 33 16 34
  • 79.83 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911499 33
  • 78.05 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP11 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP11 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP11 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP11 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20492 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.32481 33
zebrafish
(Danio rerio)
Actinopterygii dusp11 33 34
  • 62.36 (n)
wufa05e01 33
fruit fly
(Drosophila melanogaster)
Insecta CG13197 34
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pir-1 33 34
  • 51.75 (n)
T23G7.5 35
  • 42 (a)
F54C8.4 35 34
  • 38 (a)
Species where no ortholog for DUSP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP11 Gene

ENSEMBL:
Gene Tree for DUSP11 (if available)
TreeFam:
Gene Tree for DUSP11 (if available)

Paralogs for DUSP11 Gene

Paralogs for DUSP11 Gene

genes like me logo Genes that share paralogs with DUSP11: view

Variants for DUSP11 Gene

Sequence variations from dbSNP and Humsavar for DUSP11 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000366231 -- 73,767,723(-) T/C intron_variant
rs1000529318 -- 73,779,275(-) T/C intron_variant
rs1000530558 -- 73,778,545(-) C/T intron_variant
rs1000782872 -- 73,765,849(-) T/C intron_variant
rs1000801749 -- 73,772,605(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP11 Gene

Variant ID Type Subtype PubMed ID
dgv3870n100 CNV gain 25217958
esv2759060 CNV gain 17122850
nsv2780 CNV deletion 18451855
nsv508842 CNV insertion 20534489
nsv511053 OTHER complex 20534489
nsv834260 CNV gain 17160897

Variation tolerance for DUSP11 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP11 Gene

Disorders for DUSP11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUSP11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DUSP11

genes like me logo Genes that share disorders with DUSP11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP11 Gene

Publications for DUSP11 Gene

  1. PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. (PMID: 9685386) Yuan Y … Sun H (The Journal of biological chemistry 1998) 2 3 4 58
  2. Structure of human PIR1, an atypical dual-specificity phosphatase. (PMID: 24447265) Sankhala RS … Cingolani G (Biochemistry 2014) 3 4 58
  3. Isolation and characterization of DUSP11, a novel p53 target gene. (PMID: 19120688) Caprara G … Helin K (Journal of cellular and molecular medicine 2009) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activities. (PMID: 10347225) Deshpande T … Charbonneau H (The Journal of biological chemistry 1999) 3 4 58

Products for DUSP11 Gene

Sources for DUSP11 Gene

Content
Loading form....