DUSP11 Gene
protein-coding GIFtS: 51
GCID: GC02M073989
|
|
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
| |
Aliases
for DUSP11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dual Specificity Phosphatase 11 (RNA/RNP Complex 1-Interacting)1 2 | | RNA/RNP Complex-1-Interacting Phosphatase2 | | PIR11 2 3 5 | | RNA/RNP Complex-Interacting Phosphatase2 | | Dual Specificity Protein Phosphatase 112 3 | | Serine/Threonine Specific Protein Phosphatase2 | | Phosphatase That Interacts With RNA/RNP Complex 12 3 | | EC 3.1.3.-3 |
Export aliases for DUSP11 gene to outside databasesPrevious GC identifers: GC02M073998 GC02M074200 GC02M073963 GC02M073900 GC02M073723 |
Summaries
for DUSP11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DUSP11:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatasesinactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38),which is associated with cellular proliferation and differentiation. Different members of the family of dualspecificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distributionand subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. Thisgene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested toparticipate in nuclear mRNA metabolism. (provided by RefSeq, Sep 2008)
UniProtKB/Swiss-Prot: DUS11_HUMAN, O75319Function: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosinephosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism
|
Genomic Views
for DUSP11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DUSP11 gene promoter:
FOXI1 HFH-3 RFX1 E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for DUSP11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p13.1 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13.1DUSP11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M073989: view genomic region
(about GC identifiers)
Start:
|
73,989,311 bp from pter |
End:
|
74,007,284 bp from pter |
Size:
|
17,974 bases |
Orientation:
|
minus strand |
|
Proteins
for DUSP11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DUS11_HUMAN, O75319 (See
protein sequence)Recommended Name: RNA/RNP complex-1-interacting phosphatase Size: 330 amino acids; 38939 Da
Subunit: Interacts with SFRS7 and SFRS9/SRP30C
Subcellular location: Nucleus
Sequence caution: Sequence=CAH10467.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RCT8 Q6AI47 Q9BWE3Alternative splicing: 2 isoforms: O75319-1 O75319-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DUSP11: NX_O75319
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75319
DUSP11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003575.2
ENSEMBL proteins: ENSP00000272444 ENSP00000413444 ENSP00000394535 ENSP00000366935
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
DUSP11 for ontologies About GeneDecksing
DUSP11 Antibody Products:
Assay Products for DUSP11: |
Protein
Domains /
Families
for DUSP11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DUSP11 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75319ProtoNet protein and cluster: O75319 UniProtKB/Swiss-Prot: DUS11_HUMAN, O75319Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamilySimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function
for DUSP11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DUS11_HUMAN, O75319Function: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosinephosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolismEnzyme Number (IUBMB): EC 3.1.3.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for DUSP11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP11 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003723 | RNA binding |
IEA | -- | | GO:0004725 | protein tyrosine phosphatase activity |
IEA | -- | | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
IEA | -- |
DUSP11 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DUSP11:
|
Pathways & Interactions
for DUSP11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP11
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for DUSP11 (O753192, 3 ENSP000002724444) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
DUSP11 for ontologies About GeneDecksing
|
Drugs & Compounds
for DUSP11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DUSP11
Search CenterWatch for drugs/clinical trials and news about DUSP11 / DUS11
|
Transcripts
for DUSP11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DUSP11 gene: NM_003584.2 Unigene Cluster for DUSP11: Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) Hs.14611 [show with all ESTs]Unigene Representative Sequence: CR6273686 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000272444(uc002sjp.3) ENST00000480948 ENST00000477458 ENST00000443070(uc002sjq.4)
ENST00000452812 ENST00000377706
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP11 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DUSP11 (NM_003584) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUSP11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP11 |
Additional cDNA sequence: AF023917.1 AK315271.1 BC000346.2 CR627368.1 9 DOTS entries: DT.446921 DT.40199180 DT.100788426 DT.95276856 DT.120970522 DT.120970536 DT.99974072 DT.100788424 DT.91812075 24/214 AceView cDNA sequences (see all 214): CR608498 AA137118 AA968634 BU521178 AI469531 BI860793 AI360160 BM969982 AI095429 AA903047 AA808083 AA137036 AA227599 N43846 BQ773450 AA037514 AI632375 AW085972 AI354917 CA435386 AA186890 AA678896 AI367353 BQ575338
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP11 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for DUSP11
|
Expression
for DUSP11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUSP11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTACCAGAG
About this image
See DUSP11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUSP11
SOURCE GeneReport for Unigene cluster: Hs.14611
SABiosciences Custom PCR Arrays for DUSP11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP11 |
Orthologs
for DUSP11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DUSP11 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DUSP116 |
Uncharacterized protein |
42(a) |
1 ↔ 1 |
6(22237896-22247746) |
lizard
(Anolis carolinensis) |
Reptilia |
DUSP116 |
-- |
58(a) |
1 ↔ 1 |
GL343608.1(252402-257532) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.324812 |
Xenopus laevis transcribed sequence with weak similarity more |
75.38(n) |
|
BJ619513.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa05e012 |
wufa05e01 |
69.71(n) |
|
334858 57046164 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG131971 |
CG13197 |
47.5(n)
41.25(a) |
|
36253 NM_136852.1 NP_610696.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
T23G7.53
pir-11 |
tyrosine specific protein phosphatase3
Protein PIR-11 |
42(a)
(best of 2)3
51.75(n)1
42.86(a)1 |
|
II(9177150-9178307)3
1744601 NM_063558.21 NP_495959.11 |
ENSEMBL Gene Tree for DUSP11 (if available)
TreeFam Gene Tree for DUSP11 (if available) |
Paralogs
for DUSP11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DUSP11 gene
- RNGTT2
18 SIMAP similar genes for DUSP11 using alignment to 4 protein entries: DUS11_HUMAN (see all proteins):HC6 CASC4 CATSPERD ZRSR2 MST132 SEC14L3
COQ5 LOC100996300 FLJ16124 KIAA1651 pp12301 KIAA0101
SH2B3 FP6778 GALK2 GEMIN6 TUBA1C PFKFB3
DUSP11 for paralogs About GeneDecksing
|
Genomic Variants
for DUSP11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DUSP11 (73989311 - 74007284 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for DUSP11
4 CNVs: 35849 3365 35850 35851 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP11 |
|
Disorders
/ Diseases
for DUSP11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DUSP11 for disorders About GeneDecksing
OMIM gene information: 603092
OMIM disorders: --
4  diseases for DUSP11: About MalaCardskidney disease colon carcinoma carcinoma malaria
Export disorders for DUSP11 gene to outside databases
|
Publications
for DUSP11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DUSP11 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with DUSP11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PIR1, a novel phosphatase that exhibits high affinity to RNA ribonucleoprotein complexes. (PubMed id 9685386)1, 2, 3 Yuan Y.... Sun H. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activities. (PubMed id 10347225)1, 2 Deshpande T.... Charbonneau H. (1999)
- Isolation and characterization of DUSP11, a novel p53 target gene. (PubMed id 19120688)1, 9 Caprara G....Helin K. (2009)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A genome-wide metabolic QTL analysis in Europeans impl icates two loci shaped by recent positive selection. (PubMed id 21931564)1 Nicholson G....Holmes C.C. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
- Genetic loci influencing kidney function and chronic kidney disease. (PubMed id 20383145)1 Chambers J.C....Kooner J.S. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for DUSP11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DUSP11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DUSP11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DUSP11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DUSP11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DUSP11 gene:
Search GeneIP for patents involving DUSP11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DUSP11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP11 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP11 |
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