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Aliases for DUSP11 Gene

Aliases for DUSP11 Gene

  • Dual Specificity Phosphatase 11 2 3 5
  • Dual Specificity Phosphatase 11 (RNA/RNP Complex 1-Interacting) 2 3
  • Phosphatase That Interacts With RNA/RNP Complex 1 3 4
  • Dual Specificity Protein Phosphatase 11 3 4
  • RNA/RNP Complex 1-Interacting 2 3
  • PIR1 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • RNA/RNP Complex-1-Interacting Phosphatase 3
  • RNA/RNP Complex-Interacting Phosphatase 3
  • EC 3.1.3.- 4

External Ids for DUSP11 Gene

Previous GeneCards Identifiers for DUSP11 Gene

  • GC02M073998
  • GC02M074200
  • GC02M073963
  • GC02M073900
  • GC02M073989
  • GC02M073723

Summaries for DUSP11 Gene

Entrez Gene Summary for DUSP11 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

GeneCards Summary for DUSP11 Gene

DUSP11 (Dual Specificity Phosphatase 11) is a Protein Coding gene. Diseases associated with DUSP11 include Amyotrophic Lateral Sclerosis 1. GO annotations related to this gene include poly(A) RNA binding and phosphatase activity. An important paralog of this gene is RNGTT.

UniProtKB/Swiss-Prot for DUSP11 Gene

  • Possesses RNA 5-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP11 Gene

Genomics for DUSP11 Gene

Regulatory Elements for DUSP11 Gene

Enhancers for DUSP11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DUSP11 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP11 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP11 Gene

Chromosome:
2
Start:
73,762,184 bp from pter
End:
73,780,157 bp from pter
Size:
17,974 bases
Orientation:
Minus strand

Genomic View for DUSP11 Gene

Genes around DUSP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP11 Gene

Proteins for DUSP11 Gene

  • Protein details for DUSP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75319-DUS11_HUMAN
    Recommended name:
    RNA/RNP complex-1-interacting phosphatase
    Protein Accession:
    O75319
    Secondary Accessions:
    • B2RCT8
    • Q6AI47
    • Q9BWE3

    Protein attributes for DUSP11 Gene

    Size:
    330 amino acids
    Molecular mass:
    38939 Da
    Quaternary structure:
    • Monomer (PubMed:24531476). May interact with SFRS7 and SFRS9/SRP30C (PubMed:24447265).
    SequenceCaution:
    • Sequence=CAH10467.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUSP11 Gene

    Alternative splice isoforms for DUSP11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP11 Gene

Post-translational modifications for DUSP11 Gene

  • Ubiquitination at Lys 64 and Lys 231
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP11 Gene

Domains & Families for DUSP11 Gene

Gene Families for DUSP11 Gene

Suggested Antigen Peptide Sequences for DUSP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75319

UniProtKB/Swiss-Prot:

DUS11_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP11: view

Function for DUSP11 Gene

Molecular function for DUSP11 Gene

UniProtKB/Swiss-Prot Function:
Possesses RNA 5-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.

Enzyme Numbers (IUBMB) for DUSP11 Gene

Gene Ontology (GO) - Molecular Function for DUSP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 9685386
GO:0004651 polynucleotide 5-phosphatase activity IDA 10347225
GO:0004725 protein tyrosine phosphatase activity IEA,IDA 9685386
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016791 phosphatase activity IDA 24447265
genes like me logo Genes that share ontologies with DUSP11: view
genes like me logo Genes that share phenotypes with DUSP11: view

Animal Models for DUSP11 Gene

MGI Knock Outs for DUSP11:

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP11

CRISPR Products

miRNA for DUSP11 Gene

miRTarBase miRNAs that target DUSP11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP11 Gene

Localization for DUSP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP11 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP11 Gene COMPARTMENTS Subcellular localization image for DUSP11 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DUSP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9685386
GO:0016607 nuclear speck IEA,IDA 9685386
genes like me logo Genes that share ontologies with DUSP11: view

Pathways & Interactions for DUSP11 Gene

SuperPathways for DUSP11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 9685386
GO:0006470 protein dephosphorylation IDA 9685386
GO:0016070 RNA metabolic process IDA 10347225
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0098507 polynucleotide 5 dephosphorylation IDA 10347225
genes like me logo Genes that share ontologies with DUSP11: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP11 Gene

Drugs & Compounds for DUSP11 Gene

No Compound Related Data Available

Transcripts for DUSP11 Gene

Unigene Clusters for DUSP11 Gene

Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2:
SP3: - -
SP4: - -

Relevant External Links for DUSP11 Gene

GeneLoc Exon Structure for
DUSP11
ECgene alternative splicing isoforms for
DUSP11

Expression for DUSP11 Gene

mRNA expression in normal human tissues for DUSP11 Gene

Protein differential expression in normal tissues from HIPED for DUSP11 Gene

This gene is overexpressed in Adipocyte (19.6), CD8 Tcells (17.1), Fetal ovary (10.9), Placenta (6.9), and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUSP11 Gene



Protein tissue co-expression partners for DUSP11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUSP11 Gene:

DUSP11

SOURCE GeneReport for Unigene cluster for DUSP11 Gene:

Hs.14611
genes like me logo Genes that share expression patterns with DUSP11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUSP11 Gene

Orthologs for DUSP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC786531 34
  • 85.01 (n)
  • 76.9 (a)
DUSP11 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP11 34
  • 87.03 (n)
  • 79.64 (a)
DUSP11 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp11 34
  • 79.83 (n)
  • 71.66 (a)
Dusp11 16
Dusp11 35
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUSP11 34
  • 99.56 (n)
  • 98.94 (a)
DUSP11 35
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911499 34
  • 78.05 (n)
  • 70.19 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP11 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP11 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP11 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP11 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20492 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.32481 34
zebrafish
(Danio rerio)
Actinopterygii dusp11 34
  • 62.36 (n)
  • 63.27 (a)
wufa05e01 34
dusp11 35
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13197 35
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F54C8.4 36
  • 38 (a)
T23G7.5 36
  • 42 (a)
pir-1 34
  • 51.75 (n)
  • 42.86 (a)
F54C8.4 35
  • 21 (a)
OneToMany
pir-1 35
  • 35 (a)
OneToMany
Species where no ortholog for DUSP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP11 Gene

ENSEMBL:
Gene Tree for DUSP11 (if available)
TreeFam:
Gene Tree for DUSP11 (if available)

Paralogs for DUSP11 Gene

Paralogs for DUSP11 Gene

genes like me logo Genes that share paralogs with DUSP11: view

Variants for DUSP11 Gene

Sequence variations from dbSNP and Humsavar for DUSP11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2272051 -- 73,780,009(-) GGCCG(A/G)CTTGG nc-transcript-variant, reference, missense
rs7588611 -- 73,776,307(+) ctact(A/C)aggag intron-variant
rs11463165 -- 73,761,762(+) TCTCA(-/A)AAAAA downstream-variant-500B
rs11538238 -- 73,762,367(+) AGAAA(A/G)ACAAG downstream-variant-500B, utr-variant-3-prime
rs1802053 -- 73,762,462(-) TCTGT(C/T)ATTCC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DUSP11 Gene

Variant ID Type Subtype PubMed ID
dgv3870n100 CNV gain 25217958
esv2759060 CNV gain 17122850
nsv2780 CNV deletion 18451855
nsv508842 CNV insertion 20534489
nsv511053 OTHER complex 20534489
nsv834260 CNV gain 17160897

Variation tolerance for DUSP11 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP11 Gene

Disorders for DUSP11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUSP11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DUSP11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP11
genes like me logo Genes that share disorders with DUSP11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP11 Gene

Publications for DUSP11 Gene

  1. PIR1, a novel phosphatase that exhibits high affinity to RNA ribonucleoprotein complexes. (PMID: 9685386) Yuan Y. … Sun H. (J. Biol. Chem. 1998) 2 3 4 65
  2. Structure of human PIR1, an atypical dual-specificity phosphatase. (PMID: 24447265) Sankhala R.S. … Cingolani G. (Biochemistry 2014) 3 4 65
  3. Isolation and characterization of DUSP11, a novel p53 target gene. (PMID: 19120688) Caprara G. … Helin K. (J. Cell. Mol. Med. 2009) 3 22 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activities. (PMID: 10347225) Deshpande T. … Charbonneau H. (J. Biol. Chem. 1999) 3 4 65

Products for DUSP11 Gene

Sources for DUSP11 Gene

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