Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP10 Gene

protein-coding   GIFtS: 64
GCID: GC01M221874

Dual Specificity Phosphatase 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 101 2     Dual Specificity Phosphatase MKP-52
MAP Kinase Phosphatase 52 3     Dual Specificity Protein Phosphatase 102
Mitogen-Activated Protein Kinase Phosphatase 52 3     Serine/Threonine Specific Protein Phosphatase2
MKP-52 3     EC 3.1.3.163
MKP52 3     EC 3.1.3.483

External Ids:    HGNC: 30651   Entrez Gene: 112212   Ensembl: ENSG000001435077   OMIM: 6088675   UniProtKB: Q9Y6W63   

Export aliases for DUSP10 gene to outside databases

Previous GC identifers: GC01M220468 GC01M217790 GC01M218406 GC01M218931 GC01M218263 GC01M219941 GC01M192550


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP10 Gene:
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily
(MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members
of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue
distribution and subcellular localization, and different modes of inducibility of their expression by
extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its
subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is
widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three
transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DUSP10 Gene: 
DUSP10 (dual specificity phosphatase 10) is a protein-coding gene. Diseases associated with DUSP10 include colorectal cancer, and prostate cancer, and among its related super-pathways are MAPK signaling pathway and MAPK Family Pathway. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS10_HUMAN, Q9Y6W6
Function: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the
MAPK11/MAPK12/MAPK13/MAPK14 subfamily

Gene Wiki entry for DUSP10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP10 gene promoter:
         MZF-1   PPAR-gamma1   RFX1   FOXJ2   LUN-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP10 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

DUSP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M221874:  view genomic region     (about GC identifiers)

Start:
221,874,764 bp from pter      End:
221,915,518 bp from pter
Size:
40,755 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DUS10_HUMAN, Q9Y6W6 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 10  
Size: 482 amino acids; 52642 Da
Subunit: Monomer. Interacts with MAPK14
Subcellular location: Cytoplasm. Nucleus
4 PDB 3D structures from and Proteopedia for DUSP10:
1ZZW (3D)        2OUC (3D)        2OUD (3D)        3TG1 (3D)    
Secondary accessions: D3DTB4 Q6GSI4 Q9H9Z5
Alternative splicing: 2 isoforms:  Q9Y6W6-1   Q9Y6W6-2   

Explore the universe of human proteins at neXtProt for DUSP10: NX_Q9Y6W6

Explore proteomics data for DUSP10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6W6

  • DUSP10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DUSP10 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_009138.1  NP_653329.1  NP_653330.1  

    ENSEMBL proteins: 
     ENSP00000355866   ENSP00000322015   ENSP00000441302  

    Human Recombinant Protein Products for DUSP10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for DUSP10
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DUSP10
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DUSP10
    GenScript Custom Purified and Recombinant Proteins Services for DUSP10
    Novus Biologicals DUSP10 Proteins
    Novus Biologicals DUSP10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DUSP10
    Cloud-Clone Corp. Proteins for DUSP10 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS10391943
    GO:0005794Golgi apparatus IDA--

    DUSP10 for ontologies           About GeneDecksing



    DUSP10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DUSP10  (MKP-5)
    OriGene Antibodies for DUSP10
    OriGene Custom Antibody Services for DUSP10
    GenScript Custom Superior Antibodies Services for DUSP10
    Novus Biologicals DUSP10 Antibodies
    Abcam antibodies for DUSP10
    Cloud-Clone Corp. Antibodies for DUSP10 
    ThermoFisher Antibody for DUSP10
    LSBio Antibodies in human, mouse, rat for DUSP10 

    Assay Products for DUSP10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DUSP10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DUSP10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DUSP10 
    Cloud-Clone Corp. CLIAs for DUSP10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    5/8 InterPro protein domains (see all 8):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR020417 Atypical_DUSP

    Graphical View of Domain Structure for InterPro Entry Q9Y6W6

    ProtoNet protein and cluster: Q9Y6W6

    3 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001762 Disintegrin
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS10_HUMAN, Q9Y6W6
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    DUSP10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS10_HUMAN, Q9Y6W6
    Function: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the
    MAPK11/MAPK12/MAPK13/MAPK14 subfamily
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for DUSP10:
    dual specificity (tyr/thr) phosphatase 10,expressed in various tissues and organs,located evently in nucleus and
    cytoplasm and inactivating p38 and SAPK/SNK kinases

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS10391943
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016791phosphatase activity IDA16806267
    GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IBA--
         
    DUSP10 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DUSP10:
     Decreased nuclei size in G2M  Decreased telomerase activity  Increased Erk phosphorylation   Increased apoptosis 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dusp10):
     cellular  hematopoietic system  immune system 

    DUSP10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dusp10tm1Flv for DUSP10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DUSP10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DUSP10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP10 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP10
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP10 (see all 20):
    hsa-miR-411* hsa-miR-362-3p hsa-miR-379* hsa-miR-181c hsa-miR-137 hsa-miR-450a hsa-miR-25 hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidDUSP10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DUSP10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DUSP10
    Sirion Biotech Customized adenovirus for overexpression of DUSP10

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DUSP10 (see all 20)
    OriGene ORF clones in mouse, rat for DUSP10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DUSP10 (NM_007207)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP10
    Sirion Biotech Customized lentivirus for stable overexpression of DUSP10 
                         Customized lentivirus expression plasmids for stable overexpression of DUSP10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DUSP10
    Search LifeMap BioReagents cell lines for DUSP10
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DUSP10 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2TGF-Beta Pathway
    JNK Pathway0.51
    3Regulation of p38-alpha and p38-beta
    Regulation of p38-alpha and p38-beta
    4MAP Kinase Signaling
    MAP Kinase Signaling
    5ATF-2 transcription factor network
    ATF-2 transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DUSP10
        JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for DUSP10
        Phosphatases
    MAP Kinase Signaling

    3 BioSystems Pathways for DUSP10
        MAPK signaling pathway
    ATF-2 transcription factor network
    Regulation of p38-alpha and p38-beta


    1         Kegg Pathway  (Kegg details for DUSP10):
        MAPK signaling pathway


    DUSP10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for DUSP10 (Q9Y6W62, 3 ENSP000003558664) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CMTM6Q9NX762, 3, ENSP000002056364MINT-8252560 I2D: score=2 STRING: ENSP00000205636
    MAPK10P537793, ENSP000003521574I2D: score=4 STRING: ENSP00000352157
    MAPK8P459833, ENSP000003534834I2D: score=4 STRING: ENSP00000353483
    MAPK11Q157593, ENSP000003336854I2D: score=3 STRING: ENSP00000333685
    MAPK3P273613, ENSP000002630254I2D: score=2 STRING: ENSP00000263025
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IDA--
    GO:0002819regulation of adaptive immune response IEA--
    GO:0006470protein dephosphorylation IDA--
    GO:0006950response to stress TAS10391943
    GO:0007254JNK cascade TAS10391943

    DUSP10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DUSP10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP10 (DUS10)

    3 HMDB Compounds for DUSP10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for DUSP10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 56.2 4 16618780 (2)
    1,25 dihydroxy vitamin d3 54.7 2 16618780 (1)

    Search CenterWatch for drugs/clinical trials and news about DUSP10 / DUS10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DUSP10 gene (3 alternative transcripts): 
    NM_007207.4  NM_144728.2  NM_144729.2  

    Unigene Cluster for DUSP10:

    Dual specificity phosphatase 10
    Hs.497822  [show with all ESTs]
    Unigene Representative Sequence: NM_007207
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366899(uc001hmy.2 uc001hmz.2) ENST00000468085 ENST00000477026
    ENST00000494642 ENST00000323825 ENST00000544095(uc001hmx.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP10
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP10 (see all 20):
    hsa-miR-411* hsa-miR-362-3p hsa-miR-379* hsa-miR-181c hsa-miR-137 hsa-miR-450a hsa-miR-25 hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidDUSP10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DUSP10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP10
    Clone
    Products:
         
    OriGene clones in human, mouse for DUSP10 (see all 20)
    OriGene ORF clones in mouse, rat for DUSP10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DUSP10 (NM_007207)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP10
    Sirion Biotech Customized lentivirus for stable overexpression of DUSP10 
                         Customized lentivirus expression plasmids for stable overexpression of DUSP10 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DUSP10
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP10

    Additional mRNA sequence: 

    AB026436.1 AF179212.1 AK022513.1 AK293287.1 BC020608.1 BC031405.1 BC063826.1 CR457092.1 

    7 DOTS entries:

    DT.443511  DT.100737575  DT.97839824  DT.91846896  DT.121386986  DT.40121383  DT.95188463 

    24/114 AceView cDNA sequences (see all 114):

    W94942 BQ083503 NM_144728 F31067 CA448106 CA432678 N51762 BP340815 
    BC063826 BQ000769 NM_144729 BQ082194 BI820348 NM_007207 AA436489 AA257057 
    CA426702 BC031405 N49875 CA422794 AI494150 BE927275 BU183551 AI806058 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                    -     -     -           -               
    SP2:              -     -     -     -           -               
    SP3:                                            -               
    SP4:                          -     -           -               
    SP5:                                -                           


    ECgene alternative splicing isoforms for DUSP10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP10 expression in normal human tissues (normalized intensities)      DUSP10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAGTTGC
    DUSP10 Expression
    About this image


    DUSP10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
             endometrial endothelial cell   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cd8+ t cell   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See DUSP10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP10

    SOURCE GeneReport for Unigene cluster: Hs.497822

    UniProtKB/Swiss-Prot: DUS10_HUMAN, Q9Y6W6
    Tissue specificity: Detected in brain

        SABiosciences Expression via Pathway-Focused PCR Array including DUSP10: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DUSP10
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DUSP10 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp101 , 5 dual specificity phosphatase 101, 5 92.25(n)1
    96.68(a)1
      1 (88.20 cM)5
    639531  NM_022019.51  NP_071302.21 
     1840133025 
    chicken
    (Gallus gallus)
    Aves DUSP101 dual specificity phosphatase 10 83.79(n)
    89.52(a)
      421340  NM_001031044.1  NP_001026215.1 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP106
    --
    Uncharacterized protein
    89(a)
    48(a)
    1 ↔ 1
    possible ortholog
    1(244005458-244065052)
    GL343699.1(28943-34302)
    zebrafish
    (Danio rerio)
    Actinopterygii BM185549.12   -- 79.23(n)    BM185549.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta puc3 protein amino acid dephosphorylation
    protein tyrosine more
    42(a)     --


    ENSEMBL Gene Tree for DUSP10 (if available)
    TreeFam Gene Tree for DUSP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP10 gene
    DUSP42  DUSP212  SSH22  DUSP62  DUSP142  DUSP282  DUSP82  DUSP72  
    DUSP52  SSH32  DUSP162  DUSP92  DUSP22  DUSP182  SSH12  DUSP12  
    11 SIMAP similar genes for DUSP10 using alignment to 2 protein entries:     DUS10_HUMAN (see all proteins):
    DUSP19    DUSP22    DUSP3    MKP7    DUSP6    DUSP18
    DUSP4    DUSP1    DUSP2    DUSP14    DUSP21

    DUSP10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/922 SNPs in DUSP10 are shown (see all 922)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866319451,2
    --221874273(+) TGCAAC/TGCATT 3 -- ds50010--------
    rs1431427191,2
    C--221874328(+) GGGGT-/GGGGGG 3 -- ds50010--------
    rs1405041681,2
    --221874337(+) GGGTGG/TGGGGA 3 -- ds50010--------
    rs731108171,2
    C,F--221874389(+) TATCAT/AATAGC 3 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1825949061,2
    --221874466(+) CAGATG/TGGATC 3 -- ds50010--------
    rs23784551,2
    C,F,A,H--221874493(-) TGCATT/CGGGGA 3 -- ds500116Minor allele frequency- C:0.35NS EA NA WA CSA 788
    rs1174956441,2
    C,F--221874623(+) ACTGGA/TTATGT 3 -- ds50011Minor allele frequency- T:0.04EA 120
    rs1881178101,2
    --221874656(+) CTATAC/TAAAAA 3 -- ds50010--------
    rs9088571,2
    C,F,O,A,H--221874684(-) ATATAT/CAACAA 3 -- ds500126Minor allele frequency- C:0.37MN NS EA NA WA CSA 2530
    rs1456741981,2
    --221874700(+) TTACCA/TGAGCT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for DUSP10 (221874764 - 221915518 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DUSP10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv7152CNV Gain19470904
    nsv469786CNV Complex16826518

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DUSP10
    DNA2.0 Custom Variant and Variant Library Synthesis for DUSP10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608867    OMIM disorders: --

    5 diseases for DUSP10:    About MalaCards
    colorectal cancer    prostate cancer    prostatitis    gastric cancer
    leukemia


    DUSP10 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DUSP10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 47.6 3 14642090 (2), 16618780 (1)
    cancer 0 1 16618780 (1)

    Genetic Association Database (GAD): DUSP10
    Human Genome Epidemiology (HuGE) Navigator: DUSP10 (4 documents)

    Export disorders for DUSP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP10 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with DUSP10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. (PubMed id 10391943)1, 2, 3, 9 Tanoue T.... Nishida E. (1999)
    2. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. (PubMed id 10597297)1, 2, 3 Theodosiou A.... Ashworth A. (1999)
    3. Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. (PubMed id 16806267)1, 2, 9 Jeong D.G....Kim S.J. (2006)
    4. A distinct interaction mode revealed by the crystal st ructure of the kinase p38a with the MAPK binding domain of the phosphatase MKP5. (PubMed id 22375048)1, 2 Zhang Y.Y....Wang Z.X. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Meta-analysis of three genome-wide association studie s identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.1 3 and 20q13.33. (PubMed id 20972440)1, 4 Houlston R.S....Tomlinson I.P. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5. (PubMed id 17400920)1, 2 Tao X. and Tong L. (2007)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11221 HGNC: 3065 AceView: DUSP10 Ensembl:ENSG00000143507 euGenes: HUgn11221
    ECgene: DUSP10 Kegg: 11221 H-InvDB: DUSP10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DUSP10 gene:
    Search GeneIP for patents involving DUSP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DUSP10   OriGene RNAi products in human, mouse, rat for DUSP10  
     OriGene qPCR primer pairs and template standards for DUSP10   OriGene Protein Over-expression Lysate for DUSP10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DUSP10  
     OriGene qSTAR qPCR primer pairs in human, mouse for DUSP10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DUSP10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DUSP10   OriGene Custom Protein Services for DUSP10  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUSP10
     QIAGEN SeqTarget long-range PCR primers for resequencing DUSP10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP10
     GenScript Custom Purified and Recombinant Proteins Services for DUSP10 GenScript cDNA clones with any tag delivered in your preferred vector for DUSP10
     GenScript Custom Assay Services for DUSP10 GenScript Custom Superior Antibodies Services for DUSP10
     GenScript Custom overexpressing Cell Line Services for DUSP10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for DUSP10  (MKP-5)

     Regulatory tfbs in DUSP10 promoter
     Search Chromatin IP Primers for DUSP10
     RT2 qPCR Primer Assay in human, mouse, rat DUSP10
     GNC Network for DUSP10
     SABiosciences PCR Arrays including human, mouse, rat DUSP10
     Search Tocris compounds for DUSP10 (DUS10)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for DUSP10
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DUSP10 antibodies
     DUSP10 proteins
     DUSP10 lysates
     Antibodies for DUSP10
     See all of Abcam's Antibodies, Kits and Proteins for DUSP10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DUSP10




     Proteins for DUSP10
     Antibodies for DUSP10
     ELISAs for DUSP10
     CLIAs for DUSP10
     Search LifeMap BioReagents cell lines for DUSP10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP10
     SwitchGear 3'UTR luciferase reporter plasmids for DUSP10
     SwitchGear Promoter luciferase reporter plasmids for DUSP10
     ThermoFisher Antibody for DUSP10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP10
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DUSP10
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DUSP10
    Customized:
     lentivirus for stable overexpression of DUSP10
     lentivirus expression plasmids for stable overexpression of DUSP10
     adenovirus for overexpression of DUSP10
     LSBio Antibodies in human, mouse, rat for DUSP10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DUSP10 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4