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Aliases for DUSP10 Gene

Aliases for DUSP10 Gene

  • Dual Specificity Phosphatase 10 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 5 3 4
  • MKP-5 3 4
  • MKP5 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Phosphatase MKP-5 3
  • Map Kinase Phosphatase 5 3
  • MAP Kinase Phosphatase 5 4
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP10 Gene

Previous GeneCards Identifiers for DUSP10 Gene

  • GC01M220468
  • GC01M217790
  • GC01M218406
  • GC01M218931
  • GC01M218263
  • GC01M219941
  • GC01M221874
  • GC01M192550

Summaries for DUSP10 Gene

Entrez Gene Summary for DUSP10 Gene

  • Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for DUSP10 Gene

DUSP10 (Dual Specificity Phosphatase 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP10 Gene

  • Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.

Gene Wiki entry for DUSP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP10 Gene

Genomics for DUSP10 Gene

Regulatory Elements for DUSP10 Gene

Promoters for DUSP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP10 Gene

Chromosome:
1
Start:
221,701,420 bp from pter
End:
221,742,176 bp from pter
Size:
40,757 bases
Orientation:
Minus strand

Genomic View for DUSP10 Gene

Genes around DUSP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP10 Gene

Proteins for DUSP10 Gene

  • Protein details for DUSP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6W6-DUS10_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 10
    Protein Accession:
    Q9Y6W6
    Secondary Accessions:
    • D3DTB4
    • Q6GSI4
    • Q9H9Z5

    Protein attributes for DUSP10 Gene

    Size:
    482 amino acids
    Molecular mass:
    52642 Da
    Quaternary structure:
    • Monomer. Interacts with MAPK14.

    Three dimensional structures from OCA and Proteopedia for DUSP10 Gene

    Alternative splice isoforms for DUSP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP10 Gene

Proteomics data for DUSP10 Gene at MOPED

Post-translational modifications for DUSP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP10 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DUSP10 (MKP-5)

No data available for DME Specific Peptides for DUSP10 Gene

Domains & Families for DUSP10 Gene

Gene Families for DUSP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6W6

UniProtKB/Swiss-Prot:

DUS10_HUMAN :
  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP10: view

Function for DUSP10 Gene

Molecular function for DUSP10 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 10,expressed in various tissues and organs,located evently in nucleus and cytoplasm and inactivating p38 and SAPK/SNK kinases
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.

Enzyme Numbers (IUBMB) for DUSP10 Gene

Gene Ontology (GO) - Molecular Function for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP10: view
genes like me logo Genes that share phenotypes with DUSP10: view

Animal Models for DUSP10 Gene

MGI Knock Outs for DUSP10:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP10 Gene

Localization for DUSP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP10 Gene COMPARTMENTS Subcellular localization image for DUSP10 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10391943
genes like me logo Genes that share ontologies with DUSP10: view

Pathways & Interactions for DUSP10 Gene

SuperPathways for DUSP10 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 MAPK signaling pathway
genes like me logo Genes that share pathways with DUSP10: view

Pathways by source for DUSP10 Gene

SIGNOR curated interactions for DUSP10 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IDA 22375048
GO:0002819 regulation of adaptive immune response IEA --
GO:0006950 response to stress TAS 10391943
GO:0010033 response to organic substance IEA --
GO:0032496 response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with DUSP10: view

Drugs & Compounds for DUSP10 Gene

(2) Drugs for DUSP10 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(4) Additional Compounds for DUSP10 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUSP10: view

Transcripts for DUSP10 Gene

Unigene Clusters for DUSP10 Gene

Dual specificity phosphatase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for DUSP10 Gene

GeneLoc Exon Structure for
DUSP10
ECgene alternative splicing isoforms for
DUSP10

Expression for DUSP10 Gene

mRNA expression in normal human tissues for DUSP10 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP10 Gene

This gene is overexpressed in Liver (x4.4).

Protein differential expression in normal tissues from HIPED for DUSP10 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP10 Gene



SOURCE GeneReport for Unigene cluster for DUSP10 Gene Hs.497822

mRNA Expression by UniProt/SwissProt for DUSP10 Gene

Q9Y6W6-DUS10_HUMAN
Tissue specificity: Detected in brain.
genes like me logo Genes that share expression patterns with DUSP10: view

Protein tissue co-expression partners for DUSP10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DUSP10 Gene

Orthologs for DUSP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP10 35
  • 99.65 (n)
  • 99.79 (a)
DUSP10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP10 36
  • 97 (a)
OneToOne
DUSP10 35
  • 94.4 (n)
  • 96.68 (a)
dog
(Canis familiaris)
Mammalia DUSP10 35
  • 94.26 (n)
  • 96.27 (a)
DUSP10 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp10 16
Dusp10 35
  • 92.25 (n)
  • 96.68 (a)
Dusp10 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP10 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP10 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp10 35
  • 91.22 (n)
  • 95.85 (a)
chicken
(Gallus gallus)
Aves DUSP10 35
  • 83.51 (n)
  • 88.47 (a)
DUSP10 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP10 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497288 35
  • 80.88 (n)
  • 90.05 (a)
zebrafish
(Danio rerio)
Actinopterygii DUSP10 36
  • 69 (a)
OneToOne
si:ch211-180b22.4 35
  • 69.33 (n)
  • 71.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta puc 37
  • 42 (a)
puc 36
  • 22 (a)
OneToOne
Species with no ortholog for DUSP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP10 Gene

ENSEMBL:
Gene Tree for DUSP10 (if available)
TreeFam:
Gene Tree for DUSP10 (if available)

Paralogs for DUSP10 Gene

Paralogs for DUSP10 Gene

(11) SIMAP similar genes for DUSP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP10: view

Variants for DUSP10 Gene

Sequence variations from dbSNP and Humsavar for DUSP10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs982292 -- 221,718,010(-) TCAGG(A/C/T)AGCCC intron-variant
rs982293 -- 221,718,001(-) CCACA(A/G)GTTTT intron-variant
rs1136448 -- 221,739,466(-) GCCCA(A/G)ACCCA intron-variant, reference, synonymous-codon
rs1474159 -- 221,721,397(+) ACTGG(A/C)AGAAG intron-variant
rs2280340 -- 221,702,784(-) ATTCA(C/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP10 Gene

Variant ID Type Subtype PubMed ID
nsv469786 CNV Complex 16826518
esv7152 CNV Gain 19470904

Variation tolerance for DUSP10 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP10 Gene

HapMap Linkage Disequilibrium report
DUSP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP10 Gene

Disorders for DUSP10 Gene

Relevant External Links for DUSP10

Genetic Association Database (GAD)
DUSP10
Human Genome Epidemiology (HuGE) Navigator
DUSP10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP10

No disorders were found for DUSP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP10 Gene

Publications for DUSP10 Gene

  1. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. (PMID: 10391943) Tanoue T. … Nishida E. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. (PMID: 16806267) Jeong D.G. … Kim S.J. (J. Mol. Biol. 2006) 3 23
  3. JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. (PMID: 16166642) Kadoya T. … Ronai Z. (Mol. Cell. Biol. 2005) 3 23
  4. Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10. (PMID: 11060451) Masuda K. … Matsuda Y. (Cytogenet. Cell Genet. 2000) 3 23
  5. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. (PMID: 10597297) Theodosiou A. … Ashworth A. (Oncogene 1999) 2 3

Products for DUSP10 Gene

Sources for DUSP10 Gene

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