DUSP10 Gene
protein-coding GIFtS: 65
GCID: GC01M221874
|
|
dual specificity phosphatase 10
| |
Aliases
for DUSP10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dual Specificity Phosphatase 101 2 | | Dual Specificity Phosphatase MKP-52 | | MKP-51 2 3 | | Dual Specificity Protein Phosphatase 102 | | MKP51 2 3 | | Serine/Threonine Specific Protein Phosphatase2 | | MAP Kinase Phosphatase 52 3 | | EC 3.1.3.163 | | Mitogen-Activated Protein Kinase Phosphatase 52 3 | | EC 3.1.3.483 |
Export aliases for DUSP10 gene to outside databasesPrevious GC identifers: GC01M220468 GC01M217790 GC01M218406 GC01M218931 GC01M218263 GC01M219941 GC01M192550 |
Summaries
for DUSP10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DUSP10:
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both thephosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily(MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members ofthis family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissuedistribution and subcellular localization, and different modes of inducibility of their expression by extracellularstimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localizationis unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in varioustissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two differentisoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DUS10_HUMAN, Q9Y6W6Function: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for theMAPK11/MAPK12/MAPK13/MAPK14 subfamily
Gene Wiki entry for DUSP10
|
Genomic Views
for DUSP10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DUSP10 gene promoter:
MZF-1 PPAR-gamma1 RFX1 FOXJ2 LUN-1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for DUSP10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41DUSP10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M221874: view genomic region
(about GC identifiers)
Start:
|
221,874,766 bp from pter |
End:
|
221,915,518 bp from pter |
Size:
|
40,753 bases |
Orientation:
|
minus strand |
|
Proteins
for DUSP10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DUS10_HUMAN, Q9Y6W6 (See
protein sequence)Recommended Name: Dual specificity protein phosphatase 10 Size: 482 amino acids; 52642 Da
Subunit: Monomer. Interacts with MAPK14
Subcellular location: Cytoplasm. Nucleus
4 PDB 3D structures from  and Proteopedia  for DUSP10:1ZZW (3D)
2OUC (3D)
2OUD (3D)
3TG1 (3D)
Secondary accessions: D3DTB4 Q6GSI4 Q9H9Z5Alternative splicing: 2 isoforms: Q9Y6W6-1 Q9Y6W6-2 Explore the universe of human proteins at neXtProt for DUSP10: NX_Q9Y6W6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6W6
DUSP10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_009138.1 NP_653329.1 NP_653330.1
ENSEMBL proteins: ENSP00000355866 ENSP00000322015 ENSP00000441302
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
DUSP10 for ontologies About GeneDecksing
DUSP10 Antibody Products:
Assay Products for DUSP10: |
Protein
Domains /
Families
for DUSP10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DUSP10 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9Y6W6ProtoNet protein and cluster: Q9Y6W6 3 Blocks protein families: IPB000340 Dual specificity protein phosphatase IPB001762 Disintegrin IPB001763 Rhodanese-like
UniProtKB/Swiss-Prot: DUS10_HUMAN, Q9Y6W6Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamilySimilarity: Contains 1 rhodanese domainSimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function
for DUSP10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DUS10_HUMAN, Q9Y6W6Function: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for theMAPK11/MAPK12/MAPK13/MAPK14 subfamilyCatalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphate Genatlas biochemistry entry for DUSP10:dual specificity (tyr/thr) phosphatase 10,expressed in various tissues and organs,located evently in nucleus andcytoplasm and inactivating p38 and SAPK/SNK kinases
Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP10 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP10 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): DUSP10 (NM_007207) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUSP10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP10 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
DUSP10 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for DUSP10:
Animal Models:
Mouse knock-out Dusp10tm1Flv for DUSP10
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Dusp10):
DUSP10 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DUSP10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MAPK signaling pathway | | | 2 | MAP Kinase Signaling | | | 3 | ATF-2 transcription factor network | | | 4 | Regulation of p38-alpha and p38-beta | | | 5 | Phosphatases | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DUSP10
2 
Cell Signaling Technology (CST) Pathways for DUSP10
3  BioSystems Pathways for DUSP10
1 
Kegg Pathway (Kegg details for DUSP10):
DUSP10 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/19 Interacting proteins for DUSP10 (Q9Y6W62, 3 ENSP000003558664) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
DUSP10 for ontologies About GeneDecksing
|
Drugs & Compounds
for DUSP10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DUSP10 for compounds About GeneDecksing
 Browse Tocris compounds for DUSP10
3 HMDB Compounds for DUSP10 About this table
2 Novoseek chemical compound relationships for DUSP10 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| vitamin d |
56.2 |
4 |
16618780 (2) |
| 1,25 dihydroxy vitamin d3 |
54.7 |
2 |
16618780 (1) |
Search CenterWatch for drugs/clinical trials and news about DUSP10 / DUS10
|
Transcripts
for DUSP10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DUSP10 gene (3 alternative transcripts): NM_007207.4 NM_144728.2 NM_144729.2 Unigene Cluster for DUSP10: Dual specificity phosphatase 10 Hs.497822 [show with all ESTs]Unigene Representative Sequence: NM_0072076 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366899(uc001hmy.2 uc001hmz.2) ENST00000468085 ENST00000477026
ENST00000494642 ENST00000323825 ENST00000544095(uc001hmx.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP10 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP10 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): DUSP10 (NM_007207) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUSP10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP10 |
Additional cDNA sequence: AB026436.1 AF179212.1 AK022513.1 AK293287.1 BC020608.1 BC031405.1 BC063826.1 CR457092.1 7 DOTS entries: DT.443511 DT.100737575 DT.97839824 DT.91846896 DT.121386986 DT.40121383 DT.95188463 24/114 AceView cDNA sequences (see all 114): CA432678 BP340815 NM_144728 BQ083503 AA436489 BI820348 AA257057 W94942 BC063826 F31067 BC031405 NM_007207 BQ082194 NM_144729 N51762 CA426702 CA448106 BQ000769 AI273215 BI855715 BG747178 BI910451 BM309863 CA488656
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP10 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | - | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | - | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for DUSP10
|
Expression
for DUSP10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUSP10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCAGTTGC
About this image
See DUSP10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUSP10
SOURCE GeneReport for Unigene cluster: Hs.497822
UniProtKB/Swiss-Prot: DUS10_HUMAN, Q9Y6W6Tissue specificity: Detected in brain
SABiosciences Expression via Pathway-Focused PCR Array including DUSP10:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP10 |
Orthologs
for DUSP10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DUSP10 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DUSP101 |
dual specificity phosphatase 10 |
83.79(n)
89.52(a) |
|
421340 NM_001031044.1 NP_001026215.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DUSP106 |
-- |
89(a) |
1 ↔ 1 |
1(244009006-244060646) |
zebrafish
(Danio rerio) |
Actinopterygii |
BM185549.12 |
-- |
79.23(n) |
|
BM185549.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
puc3 |
protein amino acid dephosphorylation protein
tyrosine more |
42(a) |
|
-- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
DSPTP1E6 |
protein-tyrosine-phosphatase IBR5 |
18(a) |
possible ortholog |
2(1588360-1590166) |
rice
(Oryza sativa) |
Liliopsida |
---- |
dual specificity protein phosphatase, putative, ex...dual specificity protein phosphatase, putative, ex... |
16(a)16(a) |
possible orthologpossible ortholog |
2(29876197-29879380) 6(11683181-11686916) |
ENSEMBL Gene Tree for DUSP10 (if available)
TreeFam Gene Tree for DUSP10 (if available) |
Paralogs
for DUSP10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DUSP10 gene
- DUSP42 DUSP212 SSH22 DUSP62 DUSP192 DUSP142 DUSP282 DUSP82
- DUSP72 DUSP52 SSH32 DUSP162 DUSP92 DUSP22 DUSP182 SSH12
- DUSP12
13 SIMAP similar genes for DUSP10 using alignment to 2 protein entries: DUS10_HUMAN (see all proteins):DUSP19 DUSP22 DUSP3 MKP7 DUSP6 DUSP18
DUSP4 DUSP1 DUSP2 DUSP14 DUSP21 DUSP28
DUSP9
DUSP10 for paralogs About GeneDecksing
|
Genomic Variants
for DUSP10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DUSP10 (221874766 - 221915518 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DUSP10
1 Indel: 59986 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP10 |
|
Disorders
/ Diseases
for DUSP10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DUSP10 for disorders About GeneDecksing
OMIM gene information: 608867
OMIM disorders: --
5  diseases for DUSP10: About MalaCardsprostate cancer colorectal cancer prostatitis leukemia
colorectal cancer 1
2 Novoseek disease relationships for DUSP10 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| prostate cancer |
47.6 |
3 |
14642090 (2), 16618780 (1) |
| cancer |
0 |
1 |
16618780 (1) |
Human Genome Epidemiology (HuGE) Navigator: DUSP10 (4 documents)
Export disorders for DUSP10 gene to outside databases
|
Publications
for DUSP10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DUSP10 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with DUSP10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. (PubMed id 10391943)1, 2, 3, 9 Tanoue T.... Nishida E. (1999)
- MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. (PubMed id 10597297)1, 2, 3 Theodosiou A.... Ashworth A. (1999)
- Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. (PubMed id 16806267)1, 2, 9 Jeong D.G....Kim S.J. (2006)
- A distinct interaction mode revealed by the crystal st ructure of the kinase p38a with the MAPK binding domain of the phosphatase MKP5. (PubMed id 22375048)1, 2 Zhang Y.Y....Wang Z.X. (2011)
- Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5. (PubMed id 17400920)1, 2 Tao X. and Tong L. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression and comparative chromosomal mapping of MKP -5 genes DUSP10/Dusp10. (PubMed id 11060451)1, 9 Masuda K....Matsuda Y. (2000)
- Dual specificity phosphatases 10 and 16 are positive r egulators of EGF-stimulated ERK activity: indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases. (PubMed id 22245064)1 Finch A.R....McArdle C.A. (2012)
- Novel function of MKP-5/DUSP10, a phosphatase of stres s-activated kinases, on ERK-dependent gene expression, and upregulation of its g ene expression in colon carcinomas. (PubMed id 22711061)1 Nomura M....Shima H. (2012)
|
External Searches for DUSP10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DUSP10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DUSP10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DUSP10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DUSP10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DUSP10 gene:
Search GeneIP for patents involving DUSP10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DUSP10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for DUSP10 | | OriGene shRNA RFP for DUSP10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP10 | | | OriGene Protein Over-expression Lysate for DUSP10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DUSP10 | | OriGene 3'-UTR Clone for DUSP10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DUSP10 | | OriGene Custom Protein Services for DUSP10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUSP10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP10 |
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| | Antibodies & Assays for DUSP10 (MKP-5) |
| | | | Search Tocris compounds for DUSP10 |
| |  |  |  |  | | | | | | Recombinant Protein for DUSP10 |
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 | | | DUSP10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP10 |
|  |  |  | | | | ThermoFisher Antibodies for DUSP10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP10 |
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