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Aliases for DUSP1 Gene

Aliases for DUSP1 Gene

  • Dual Specificity Phosphatase 1 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 1 3 4
  • Dual Specificity Protein Phosphatase HVH1 3 4
  • Protein-Tyrosine Phosphatase CL100 3 4
  • MAP Kinase Phosphatase 1 3 4
  • PTPN10 3 4
  • CL100 3 4
  • MKP-1 3 4
  • MKP1 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 1 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • CL 100 3
  • HVH1 3
  • VH1 4

External Ids for DUSP1 Gene

Previous HGNC Symbols for DUSP1 Gene

  • PTPN10

Previous GeneCards Identifiers for DUSP1 Gene

  • GC05M172450
  • GC05M172896
  • GC05M172130
  • GC05M172176
  • GC05M172127
  • GC05M167290
  • GC05M172195

Summaries for DUSP1 Gene

Entrez Gene Summary for DUSP1 Gene

  • The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]

GeneCards Summary for DUSP1 Gene

DUSP1 (Dual Specificity Phosphatase 1) is a Protein Coding gene. Diseases associated with DUSP1 include Multiple Cranial Nerve Palsy and Amyotrophic Lateral Sclerosis 9. Among its related pathways are RET signaling and RAF-independent MAPK1/3 activation. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot for DUSP1 Gene

  • Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both Thr-183 and Tyr-185, regulating its activity during the meiotic cell cycle.

Gene Wiki entry for DUSP1 Gene

Additional gene information for DUSP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP1 Gene

Genomics for DUSP1 Gene

Regulatory Elements for DUSP1 Gene

Enhancers for DUSP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H172763 2.4 VISTA FANTOM5 ENCODE dbSUPER 41.1 -1.0 -1000 16 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A DUSP1 CREBRF KLF3P1 ERGIC1 ENSG00000253628 ENSG00000253172 SMIM23 BOD1 EFCAB9 LOC100268168
GH05H172877 2 FANTOM5 Ensembl ENCODE dbSUPER 19.1 -109.6 -109566 6 HDGF PKNOX1 ATF1 ZNF766 ELK1 ZNF143 ZNF207 FOS ATF7 RUNX3 DUSP1 ERGIC1 ENSG00000254295 RPL26L1 LOC100268168 BNIP1 CREBRF
GH05H172884 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.4 -115.5 -115547 4 SIN3A RAD21 RARA YY1 THAP11 CEBPB REST NR2F2 TGIF2 NFIL3 DUSP1 ENSG00000253445 ERGIC1 ENSG00000254295 RPL26L1 LOC100268168 CREBRF
GH05H172894 2 FANTOM5 Ensembl ENCODE dbSUPER 16.4 -129.7 -129748 12 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B KLF3P1 BOD1 BNIP1 SH3PXD2B UBTD2 ERGIC1 DUSP1 ENSG00000253628 ENSG00000253172 CREBRF
GH05H172787 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -24.5 -24543 16 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B YBX1 ZBTB7B YY1 ZNF766 ERGIC1 CREBRF BOD1 SH3PXD2B DUSP1 FBXW11 LOC105377730 LOC401218 LOC100130394 ENSG00000270243
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUSP1 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000318586 300 3401 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A PPARGC1A

Genomic Location for DUSP1 Gene

Chromosome:
5
Start:
172,768,090 bp from pter
End:
172,771,200 bp from pter
Size:
3,111 bases
Orientation:
Minus strand

Genomic View for DUSP1 Gene

Genes around DUSP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP1 Gene

Proteins for DUSP1 Gene

  • Protein details for DUSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28562-DUS1_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 1
    Protein Accession:
    P28562
    Secondary Accessions:
    • D3DQL9
    • Q2V508

    Protein attributes for DUSP1 Gene

    Size:
    367 amino acids
    Molecular mass:
    39298 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUSP1 Gene

Post-translational modifications for DUSP1 Gene

  • Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.
  • Ubiquitination at isoforms=280
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DUSP1 (DUSP1)

No data available for DME Specific Peptides for DUSP1 Gene

Domains & Families for DUSP1 Gene

Gene Families for DUSP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P28562

UniProtKB/Swiss-Prot:

DUS1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP1: view

Function for DUSP1 Gene

Molecular function for DUSP1 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 1,reversing the activation of mitogen-activated protein (MAP) kinase family,vaccinia virus phosphatase VH1-like 1,induced by EGF,predominantly expressed in lung,placenta,pancreas,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both Thr-183 and Tyr-185, regulating its activity during the meiotic cell cycle.
UniProtKB/Swiss-Prot Induction:
By oxidative stress and heat shock.

Enzyme Numbers (IUBMB) for DUSP1 Gene

Phenotypes From GWAS Catalog for DUSP1 Gene

Gene Ontology (GO) - Molecular Function for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS 1406996
GO:0005515 protein binding IPI 8626452
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA,IDA 17498703
genes like me logo Genes that share ontologies with DUSP1: view
genes like me logo Genes that share phenotypes with DUSP1: view

Animal Models for DUSP1 Gene

MGI Knock Outs for DUSP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DUSP1
  • Applied Biological Materials Clones for DUSP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP1 Gene

Localization for DUSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 7593328
GO:0005737 cytoplasm IDA 7593328
genes like me logo Genes that share ontologies with DUSP1: view

Pathways & Interactions for DUSP1 Gene

SuperPathways for DUSP1 Gene

SuperPathway Contained pathways
1 RET signaling
2 MAPK signaling pathway
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with DUSP1: view

SIGNOR curated interactions for DUSP1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity ISS --
GO:0001706 endoderm formation IBA --
GO:0006470 protein dephosphorylation IEA --
GO:0006979 response to oxidative stress TAS 1406996
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with DUSP1: view

Drugs & Compounds for DUSP1 Gene

(36) Drugs for DUSP1 Gene - From: PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Salbutamol Approved, Vet_approved Pharma Partial agonist, Agonist 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0
Sanguinarine chloride Pharma Inhibitor of PP2C and MKP-1 0

(21) Additional Compounds for DUSP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2

(1) ApexBio Compounds for DUSP1 Gene

Compound Action Cas Number
Sanguinarine chloride Inhibitor of PP2C and MKP-1 5578-73-4
genes like me logo Genes that share compounds with DUSP1: view

Drug Products

Transcripts for DUSP1 Gene

mRNA/cDNA for DUSP1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(622) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP1 Gene

Dual specificity phosphatase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DUSP1
  • Applied Biological Materials Clones for DUSP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -
SP4:

Relevant External Links for DUSP1 Gene

GeneLoc Exon Structure for
DUSP1
ECgene alternative splicing isoforms for
DUSP1

Expression for DUSP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP1 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP1 Gene

This gene is overexpressed in Whole Blood (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUSP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of DUSP1 Gene:

DUSP1

SOURCE GeneReport for Unigene cluster for DUSP1 Gene:

Hs.171695

mRNA Expression by UniProt/SwissProt for DUSP1 Gene:

P28562-DUS1_HUMAN
Tissue specificity: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.

Evidence on tissue expression from TISSUES for DUSP1 Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Eye(3.9)
  • Muscle(3.9)
  • Heart(3.5)
  • Kidney(3.5)
  • Blood(3.4)
  • Liver(3.4)
  • Pancreas(3.4)
  • Intestine(3.2)
  • Bone marrow(3)
  • Skin(3)
  • Adrenal gland(2.9)
  • Spleen(2.9)
  • Thyroid gland(2.7)
  • Lymph node(2.6)
  • Gall bladder(2.5)
  • Bone(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with DUSP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP1 Gene

Orthologs for DUSP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUSP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP1 33 34
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia DUSP1 33 34
  • 92.82 (n)
mouse
(Mus musculus)
Mammalia Dusp1 16 34 33
  • 90.19 (n)
rat
(Rattus norvegicus)
Mammalia Dusp1 33
  • 89.55 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP1 34
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP1 33 34
  • 84.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP1 34 33
  • 80.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP1 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp1 33
  • 70.59 (n)
Str.6379 33
zebrafish
(Danio rerio)
Actinopterygii dusp1 33 34
  • 68.53 (n)
Dr.2413 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPS1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5253 33
Species where no ortholog for DUSP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP1 Gene

ENSEMBL:
Gene Tree for DUSP1 (if available)
TreeFam:
Gene Tree for DUSP1 (if available)

Paralogs for DUSP1 Gene

Paralogs for DUSP1 Gene

(8) SIMAP similar genes for DUSP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP1: view

Variants for DUSP1 Gene

Sequence variations from dbSNP and Humsavar for DUSP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000222677 -- 172,772,183(+) GGCTC(C/T)AGACT upstream-variant-2KB
rs1000517485 -- 172,771,375(+) AGCCT(C/T)GGAGC upstream-variant-2KB
rs1000685993 -- 172,770,999(+) TCTTT(G/T)TCTGT upstream-variant-2KB, utr-variant-5-prime
rs1000823494 -- 172,771,213(+) CCGGG(A/G)AGCGC upstream-variant-2KB
rs1001351105 -- 172,767,879(+) CACAC(G/T)GATCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DUSP1 Gene

Variant ID Type Subtype PubMed ID
esv2759393 CNV gain 17122850
nsv600294 CNV loss 21841781

Variation tolerance for DUSP1 Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP1 Gene

Human Gene Mutation Database (HGMD)
DUSP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP1 Gene

Disorders for DUSP1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DUSP1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
multiple cranial nerve palsy
  • multiple cranial nerve palsies
amyotrophic lateral sclerosis 9
  • amyotrophic lateral sclerosis type 9
amyotrophic lateral sclerosis 7
  • amyotrophic lateral sclerosis type 7
glossopharyngeal nerve disease
  • glossopharyngeal nerve diseases
- elite association - COSMIC cancer census association via MalaCards
Search DUSP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUSP1

Genetic Association Database (GAD)
DUSP1
Human Genome Epidemiology (HuGE) Navigator
DUSP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP1
genes like me logo Genes that share disorders with DUSP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP1 Gene

Publications for DUSP1 Gene

  1. Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene. (PMID: 8106404) Kwak SP … Dixon JE (The Journal of biological chemistry 1994) 3 4 22 60
  2. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. (PMID: 1406996) Keyse SM … Emslie EA (Nature 1992) 2 3 4 60
  3. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PMID: 20805296) Coulthard LR … McDermott MF (Annals of the rheumatic diseases 2011) 3 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Angiotensin II signaling via type 2 receptors in a human model of vascular hyporeactivity: implications for hypertension. (PMID: 19797979) Calò LA … Pessina AC (Journal of hypertension 2010) 3 22 60

Products for DUSP1 Gene

  • Addgene plasmids for DUSP1

Sources for DUSP1 Gene

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