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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DUSP1 Gene

protein-coding GIFtS: 68
GCID: GC05M172195

dual specificity phosphatase 1

(Previous symbol: PTPN10)

Explore 51 diseases affiliated with
DUSP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 1¹ ²		MKP1² ³
CL100¹ ² ³ ⁵		MAP Kinase Phosphatase 1² ³
PTPN10¹ ² ³ ⁵		Dual Specificity Protein Phosphatase 1²
MKP-1¹ ² ³		Serine/Threonine Specific Protein Phosphatase²
HVH1¹ ²		EC 3.1.3.16³
Dual Specificity Protein Phosphatase HVH1² ³		EC 3.1.3.48³
Mitogen-Activated Protein Kinase Phosphatase 1² ³		VH1³
Protein-Tyrosine Phosphatase CL100² ³

External Ids:	HGNC: 3064¹	Entrez Gene: 1843²	Ensembl: ENSG00000120129⁷	OMIM: 600714⁵	UniProtKB: P28562³

Export aliases for DUSP1 gene to outside databases

Previous GC identifers: GC05M172450 GC05M172896 GC05M172130 GC05M172176 GC05M172127 GC05M167290

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP1:

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It

specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase

family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late

gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity,

and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of

both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by

oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to

environmental stress as well as in the negative regulation of cellular proliferation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562

Function: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185',

regulating its activity during the meiotic cell cycle (By similarity)

Gene Wiki entry for DUSP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DUSP1 gene promoter:
CREB Elk-1 Sp1 deltaCREB STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DUSP1 promoter sequence

Search SABiosciences Chromatin IP Primers for DUSP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34 Ensembl cytogenetic band: 5q35.1 HGNC cytogenetic band: 5q35.1

DUSP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M172195: view genomic region (about GC identifiers)

Start:	172,195,093 bp from pter	End:	172,198,203 bp from pter
Size:	3,111 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562 (See protein sequence)

Recommended Name: Dual specificity protein phosphatase 1

Size: 367 amino acids; 39298 Da

Subcellular location: Nucleus (By similarity)

Secondary accessions: D3DQL9 Q2V508

Explore the universe of human proteins at neXtProt for DUSP1: NX_P28562

Post-translational modifications:

Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P28562

DUSP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004408.1

ENSEMBL proteins:

ENSP00000239223

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant DUSP1 Protein
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DUSP1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	IBA	--

DUSP1 for ontologies About GeneDecksing

DUSP1 Antibody Products:

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	Novus Biologicals DUSP1 Antibodies
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	Uscn Antibodies for DUSP1
	ThermoFisher Antibodies for DUSP1

Assay Products for DUSP1:

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	GenScript Custom Assay Services for DUSP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DUSP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DUSP1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR001763 Rhodanese-like_dom

IPR000387 Tyr/Dual-sp_Pase

IPR020422 Dual-sp_phosphatase_subgr_cat

IPR016130 Tyr_Pase_AS

IPR020417 Atypical_DUSP

Graphical View of Domain Structure for InterPro Entry P28562

ProtoNet protein and cluster: P28562

2 Blocks protein families:

IPB000340 Dual specificity protein phosphatase

IPB001763 Rhodanese-like

UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily

Similarity: Contains 1 rhodanese domain

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562

Function: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185',

regulating its activity during the meiotic cell cycle (By similarity)

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

Induction: By oxidative stress and heat shock

Genatlas biochemistry entry for DUSP1:

dual specificity (tyr/thr) phosphatase 1,reversing the activation of mitogen-activated protein (MAP) kinase

family,vaccinia virus phosphatase VH1-like 1,induced by EGF,predominantly expressed in lung,placenta,pancreas,involved

in signal transduction

Enzyme Numbers (IUBMB): EC 3.1.3.16¹ EC 3.1.3.48¹

miRNA Products:		miRTarBase miRNAs that target DUSP1: hsa-mir-101 (MIRT005876)

		OriGene 3'-UTR Clone: DUSP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP1
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP1 (see all 29):
		hsa-let-7d hsa-miR-429 hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-miR-144 hsa-let-7a

		SwitchGear 3'UTR luciferase reporter plasmid: DUSP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP1 (see all 7) OriGene shRNA RFP: DUSP1 OriGene siRNA: DUSP1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DUSP1

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		GenScript: all cDNA clones in your preferred vector: DUSP1 (NM_004417)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DUSP1
		Search LifeMap BioReagents cell lines for DUSP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	TAS	1406996
GO:0005515	protein binding	IPI	16286470
GO:0008330	protein tyrosine/threonine phosphatase activity	IEA	--
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	IBA	--

DUSP1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for DUSP1:

Decreased focal adhesion (FA)

Decreased viability with pacli

Animal Models:
Mouse knock-outs for DUSP1: Dusp1^tm1Brv Dusp1^{tm1(KOMP)Wtsi}
14 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dusp1):

adipose tissue	behavior/neurological	cardiovascular system	cellular	growth/size
hematopoietic system	homeostasis/metabolism	immune system	liver/biliary system	mortality/aging
muscle	nervous system	respiratory system	skeleton

DUSP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription_P53 signaling pathway

Transcription_P53 signaling pathway

1.00

Transcription P53 signaling pathway

0.98

Signal transduction Erk Interactions: Inhibition of Erk

Signal transduction Erk Interactions: Inhibition of Erk

1.00

Signal transduction_Erk Interactions- Inhibition of Erk

0.92

MAPK signaling pathway

MAPK signaling pathway

1.00

MAPK signaling pathway

0.50

Development EGFR signaling pathway

Development EGFR signaling pathway

1.00

Development_EGFR signaling pathway

0.87

Phosphatases

Phosphatases

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for DUSP1

	Selected targets of GCR-alpha
	Development EGFR signaling pathway
	Signal transduction Erk Interactions- Inhibition of Erk
	Transcription P53 signaling pathway

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DUSP1

	ERK Signaling
	NTHi-Induced Signaling
	Aldosterone Signaling in Epithelial Cells
	JNK Pathway

2 Cell Signaling Technology (CST) Pathways for DUSP1

	Phosphatases
	MAP Kinase Signaling

3 GeneGo (Thomson Reuters) Pathways for DUSP1

	Signal transduction Erk Interactions- Inhibition of Erk
	Transcription P53 signaling pathway
	Development EGFR signaling pathway

5/7 BioSystems Pathways for DUSP1 (see all 7)

	EGFR1 Signaling Pathway
	MAPK signaling pathway
	ErbB1 downstream signaling
	Fc-epsilon receptor I signaling in mast cells
	Regulation of p38-alpha and p38-beta

1 Kegg Pathway (Kegg details for DUSP1):

MAPK signaling pathway

DUSP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DUSP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/32 Interacting proteins for DUSP1 (P28562^{1, 2, 3} ENSP00000239223⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK1	P28482¹^,²^,³, ENSP00000215832⁴	EBI-975493,EBI-959949 MINT-8291556 MINT-8291551 MINT-8217047 I2D: score=6 STRING: ENSP00000215832
SKP2	Q13309¹^,³, ENSP00000274255⁴	EBI-975493,EBI-456291 I2D: score=4 STRING: ENSP00000274255
UBB	P0CG47¹^,³, ENSP00000304697⁴	EBI-975493,EBI-413034 I2D: score=3 STRING: ENSP00000304697
MAPK9	P45984²^,³, ENSP00000321410⁴	MINT-8217423 I2D: score=2 STRING: ENSP00000321410
JUN	P05412²^,³, ENSP00000360266⁴	MINT-8287203 I2D: score=1 STRING: ENSP00000360266

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000188	inactivation of MAPK activity	IBA	--
GO:0001706	endoderm formation	IBA	--
GO:0006470	protein dephosphorylation	IBA	--
GO:0006979	response to oxidative stress	TAS	1406996
GO:0007049	cell cycle	IEA	--

DUSP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DUSP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DUSP1

3 HMDB Compounds for DUSP1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/52 Novoseek chemical compound relationships for DUSP1 gene (see all 52) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cl 100	95.9	82	7780739 (7), 8106404 (7), 8168826 (6), 8390041 (5) (see all 27)
triptolide	74	21	19893732 (5), 19289102 (1), 19476641 (1), 19755862 (1) (see all 9)
pd 98,059	61.9	14	9202001 (1), 10473620 (1), 16081065 (1), 10873641 (1) (see all 12)
sodium orthovanadate	60.7	6	11278958 (2), 15242861 (1), 7585624 (1)
dexamethasone	57.1	78	12391149 (6), 17513787 (5), 15476200 (4), 18652821 (4) (see all 26)
sb 203580	53.2	6	19648110 (1), 11577072 (1), 9501207 (1), 11689710 (1) (see all 5)
tyrosine	52.8	57	18434324 (3), 7780739 (2), 17207923 (2), 8390041 (2) (see all 24)
ag 1478	51.9	5	19175673 (2), 16081869 (1)
vanadate	50.9	11	12529177 (2), 19893732 (2), 12186877 (1), 7700643 (1) (see all 6)
manumycin	48.5	3	12452012 (3)

Search CenterWatch for drugs/clinical trials and news about DUSP1 / DUS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DUSP1 gene:

NM_004417.3

Unigene Cluster for DUSP1:

Dual specificity phosphatase 1

Hs.171695 [show with all ESTs]

Unigene Representative Sequence: NM_004417

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000239223(uc003mbu.2 uc003mbv.2)

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		hsa-let-7d hsa-miR-429 hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-miR-144 hsa-let-7a

		SwitchGear 3'UTR luciferase reporter plasmid: DUSP1 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DUSP1 (NM_004417)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP1

Additional cDNA sequence:

AJ227912.1 AK298047.1 AK298658.1 AK299391.1 AK300487.1 AK304475.1 AK316321.1 BC022463.1

X68277.1

18 DOTS entries:

DT.450715 DT.97854855 DT.101961185 DT.100878604 DT.100878597 DT.100878602 DT.95169301 DT.120864071

DT.120864104 DT.91667554 DT.100878599 DT.100878606 DT.95169300 DT.100878594 DT.100878596 DT.100878600

DT.120864086 DT.92049103

24/622 AceView cDNA sequences (see all 622):

AI190594 AI685606 BI770809 AI004940 BF589269 AI305811 CA397855 CD674224

CA418601 AA393264 AI200726 AI126316 BG739959 AI524312 AI952977 AI247358

BF221829 BE856682 CF131933 W90037 AI635760 AI224392 AA074913 AI972380

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c
SP1:									-
SP2:
SP3:									-		-
SP4:

ECgene alternative splicing isoforms for DUSP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DUSP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGACATAC

About this image

DUSP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Bone

Bone

Lumbar Intervertebral Disc

Cartilage

Primitive Streak

Notochord

Primitive Streak

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

Nkx2-1 GFP+ cells (Efficient derivation...)

See DUSP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUSP1

SOURCE GeneReport for Unigene cluster: Hs.171695

UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562

Tissue specificity: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the

heart and skeletal muscle. Lower levels found in the brain and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including DUSP1 (see all 7):

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

TNF Ligands & Receptors in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

EGF / PDGF Signaling Pathway in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP1 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dusp1^{1 , 5}	dual specificity phosphatase 1^{1, 5}	90.19(n)¹ 96.46(a)¹		17 (13.28 cM)⁵ 19252¹ NM_013642.3¹ NP_038670.1¹ 26505590⁵
chicken (Gallus gallus)	Aves	DUSP1¹	dual specificity phosphatase 1	80.37(n) 83.84(a)		374192 NM_001085359.1 NP_001078828.1
lizard (Anolis carolinensis)	Reptilia	DUSP1⁶	--	80(a)	1 ↔ 1	2(124308388-124311065)
African clawed frog (Xenopus laevis)	Amphibia	BC055962.1²	--	76.55(n)		BC055962.1
zebrafish (Danio rerio)	Actinopterygii	Dr.2413²	Danio rerio mRNA similar to dual specificity phosphatase more	76.14(n)		BC045494.1
thale cress (Arabidopsis thaliana)	eudicotyledons	DSPTP1E⁶	protein-tyrosine-phosphatase IBR5	21(a)	possible ortholog	2(1588360-1590166)
rice (Oryza sativa)	Liliopsida	-- --	dual specificity protein phosphatase, putative, ex... dual specificity protein phosphatase, putative, ex...	18(a) 17(a)	possible ortholog possible ortholog	2(29876197-29879380) 6(11683181-11686916)

ENSEMBL Gene Tree for DUSP1 (if available)
TreeFam Gene Tree for DUSP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DUSP1 gene

DUSP4² DUSP21² SSH2² DUSP10² DUSP6² DUSP19² DUSP14² DUSP28²

DUSP8² DUSP7² DUSP5² SSH3² DUSP16² DUSP9² DUSP2² DUSP18²

SSH1²

8 SIMAP similar genes for DUSP1 using alignment to 1 protein entry: DUS1_HUMAN:

DUSP4 DUSP2 DUSP5 DUSP10 DUSP6 DUSP8

DUSP7 DUSP9

DUSP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35265488^1,2	C,F,	--	172194628(-)	`AACTC-/TTGAGCAA`	1	--	ds500¹		5		NS	188
rs147274784^1,2		--	172194728(+)	`GGAAGA/GCGACT`	1	--	ds500¹		0	--	--	--	--
rs35916724^1,2	C,F,	--	172194757(-)	`TTTAAT/CACCCT`	1	--	ds500¹		6		NS WA	308
rs189822337^1,2		--	172194852(+)	`TACAGA/GGCCGC`	1	--	ds500¹		0	--	--	--	--
rs322351^1,2	C,F,A,H,	--	172194873(+)	`ATGGGC/TAGACA`	1	--	ds500¹		25		NS EA NA WA	3830
rs200587648^1,2		--	172194928(+)	`ATGAT-/ACTC ACTTG`	1	--	ds500¹		0	--	--	--	--
rs201965027^1,2		--	172194932(+)	`TACTC-/ACTT GTCTT`	1	--	ds500¹		0	--	--	--	--
rs78081495^1,2		--	172195063(+)	`AGGGAC/TTGGGT`	1	--	ds500¹		0	--	--	--	--
rs3805476^1,2	C,F,	--	172195092(+)	`AAAGCG/ATTGAA`	1	--	ds500¹		13		NA NS WA CSA EA	558
rs34412722^1,2	C,	--	172195133(-)	`TTTTTA/GTACAA`	1	--	ut3¹		6		NS WA	308

HapMap Linkage Disequilibrium report for DUSP1 (172195093 - 172198203 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DUSP1
1 CNV: 2608

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP1

DNA2.0 Custom Variant and Variant Library Synthesis for DUSP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DUSP1 for disorders           About GeneDecksing

OMIM gene information: 600714    OMIM disorders: --

20/51 diseases for DUSP1 (see all 51):    About MalaCards

vaccinia inclusion body myositis insulin resistance haemophilus influenzae

lymphoblastic leukemia systemic lupus erythematosus squamous cell carcinoma lupus erythematosus

lung squamous cell carcinoma acute lymphoblastic leukemia myositis epithelial ovarian cancer

ovarian cancer pheochromocytoma hyperglycemia bronchitis

hepatocellular carcinoma ovarian carcinoma rheumatoid arthritis multiple sclerosis

10/28 Novoseek disease relationships for DUSP1 gene (see all 28) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	32.5	12	15640643 (3), 15569826 (1), 18495502 (1), 18508759 (1) (see all 8)
tumors	29.7	49	8909245 (4), 15640643 (3), 12432554 (3), 9010448 (2) (see all 24)
shock	27.1	17	15640643 (4), 12748284 (2), 15677475 (1), 7780739 (1) (see all 10)
prostatic intraepithelial neoplasia	17.6	2	9645439 (1)
hypertrophy	16.7	1	15313208 (1)
ovarian cancer	16	4	18089824 (2), 19755862 (1), 19697705 (1)
breast cancer	14.9	24	19417026 (6), 20111893 (2), 17483361 (2), 14695202 (2) (see all 9)
cancer	13.4	14	18922965 (3), 15243131 (2), 15856297 (1), 11710837 (1) (see all 9)
breast carcinoma	11.2	4	19417026 (1), 15448190 (1), 8909245 (1), 17483361 (1)
inflammation	4.66	6	16387640 (2), 18922786 (1), 20043958 (1), 16317391 (1)

Genetic Association Database (GAD): DUSP1
Human Genome Epidemiology (HuGE) Navigator: DUSP1 (13 documents)

Export disorders for DUSP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DUSP1 gene, integrated from 9 sources (see all 377):
(articles sorted by number of sources associating them with DUSP1)

Utopia: connect your pdf to the dynamic
world of online information

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. (PubMed id 1406996)^{1, 2, 3} Keyes S.M. and Emslie E.A. (1992)
Isolation and characterization of a human dual specificity protein- tyrosine phosphatase gene. (PubMed id 8106404)^{1, 2, 9} Kwak S.P.... Dixon J.E. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Association of homozygous deletion of the Humhv3005 and the VH3-30.3 genes with renal involvement in systemic lupus erythematosus. (PubMed id 12765304)^{1, 4} Cho M.L....Cho C.S. (2003)
Chromosomal localization of four human VH1-like protein-tyrosine phosphatases. (PubMed id 7806236)^{1, 3} Martell K.J....Trent J.M. (1994)
Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma. (PubMed id 12432554)^{1, 9} Denkert C....Hauptmann S. (2002)
VEGF and thrombin induce MKP-1 through distinct signaling pathways: role for MKP-1 in endothelial cell migration. (PubMed id 18003751)^{1, 9} Kinney C.M....DiCorleto P.E. (2008)
Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin. (PubMed id 19417026)^{1, 9} Rojo F....Albanell J. (2009)
KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. (PubMed id 19411256)^{1, 9} Liu R....Chen C. (2009)
ERK-dependent MKP-1-mediated cisplatin resistance in human ovarian cancer cells. (PubMed id 18089824)^{1, 9} Wang J....Wu G.S. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1843	HGNC: 3064	AceView: DUSP1	Ensembl:ENSG00000120129	euGenes: HUgn1843
ECgene: DUSP1	Kegg: 1843	H-InvDB: DUSP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DUSP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DUSP1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/dusp1/

Intellectual Property for DUSP1 gene
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Patent Information for DUSP1 gene:
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GeneCards and IP:
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dual specificity phosphatase 1

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