Aliases for DUSP1 Gene
External Ids for DUSP1 Gene
Previous HGNC Symbols for DUSP1 Gene
Previous GeneCards Identifiers for DUSP1 Gene
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for DUSP1 Gene
DUSP1 (Dual Specificity Phosphatase 1) is a Protein Coding gene. Diseases associated with DUSP1 include Vaccinia and Amyotrophic Lateral Sclerosis 7. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Circadian entrainment. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.
UniProtKB/Swiss-Prot for DUSP1 Gene
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both Thr-183 and Tyr-185, regulating its activity during the meiotic cell cycle.