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Aliases for DUSP1 Gene

Aliases for DUSP1 Gene

  • Dual Specificity Phosphatase 1 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 1 3 4
  • Dual Specificity Protein Phosphatase HVH1 3 4
  • Protein-Tyrosine Phosphatase CL100 3 4
  • MAP Kinase Phosphatase 1 3 4
  • PTPN10 3 4
  • CL100 3 4
  • MKP-1 3 4
  • MKP1 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • CL 100 3
  • HVH1 3
  • VH1 4

External Ids for DUSP1 Gene

Previous HGNC Symbols for DUSP1 Gene

  • PTPN10

Previous GeneCards Identifiers for DUSP1 Gene

  • GC05M172450
  • GC05M172896
  • GC05M172130
  • GC05M172176
  • GC05M172127
  • GC05M167290
  • GC05M172195

Summaries for DUSP1 Gene

Entrez Gene Summary for DUSP1 Gene

  • The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP1 Gene

DUSP1 (Dual Specificity Phosphatase 1) is a Protein Coding gene. Diseases associated with DUSP1 include vaccinia and amyotrophic lateral sclerosis 7. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP1 Gene

  • Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both Thr-183 and Tyr-185, regulating its activity during the meiotic cell cycle.

Gene Wiki entry for DUSP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP1 Gene

Genomics for DUSP1 Gene

Regulatory Elements for DUSP1 Gene

Promoters for DUSP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP1 Gene

Chromosome:
5
Start:
172,768,090 bp from pter
End:
172,771,200 bp from pter
Size:
3,111 bases
Orientation:
Minus strand

Genomic View for DUSP1 Gene

Genes around DUSP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP1 Gene

Proteins for DUSP1 Gene

  • Protein details for DUSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28562-DUS1_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 1
    Protein Accession:
    P28562
    Secondary Accessions:
    • D3DQL9
    • Q2V508

    Protein attributes for DUSP1 Gene

    Size:
    367 amino acids
    Molecular mass:
    39298 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUSP1 Gene

Proteomics data for DUSP1 Gene at MOPED

Post-translational modifications for DUSP1 Gene

  • Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.
  • Ubiquitination at Lys 280
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DUSP1 (MKP-1)

No data available for DME Specific Peptides for DUSP1 Gene

Domains & Families for DUSP1 Gene

Gene Families for DUSP1 Gene

Graphical View of Domain Structure for InterPro Entry

P28562

UniProtKB/Swiss-Prot:

DUS1_HUMAN :
  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP1: view

Function for DUSP1 Gene

Molecular function for DUSP1 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 1,reversing the activation of mitogen-activated protein (MAP) kinase family,vaccinia virus phosphatase VH1-like 1,induced by EGF,predominantly expressed in lung,placenta,pancreas,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both Thr-183 and Tyr-185, regulating its activity during the meiotic cell cycle.
UniProtKB/Swiss-Prot Induction:
By oxidative stress and heat shock.

Enzyme Numbers (IUBMB) for DUSP1 Gene

Gene Ontology (GO) - Molecular Function for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8626452
GO:0008330 protein tyrosine/threonine phosphatase activity IEA --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA,ISS --
GO:0019838 growth factor binding IEA --
genes like me logo Genes that share ontologies with DUSP1: view
genes like me logo Genes that share phenotypes with DUSP1: view

Animal Models for DUSP1 Gene

MGI Knock Outs for DUSP1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP1 Gene

Localization for DUSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP1 Gene COMPARTMENTS Subcellular localization image for DUSP1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DUSP1 Gene

Pathways & Interactions for DUSP1 Gene

SuperPathways for DUSP1 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 MAPK signaling pathway
genes like me logo Genes that share pathways with DUSP1: view

SIGNOR curated interactions for DUSP1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity ISS --
GO:0001706 endoderm formation IBA --
GO:0006470 protein dephosphorylation IEA --
GO:0006979 response to oxidative stress TAS 1406996
GO:0009416 response to light stimulus IEA --
genes like me logo Genes that share ontologies with DUSP1: view

Drugs & Compounds for DUSP1 Gene

(28) Drugs for DUSP1 Gene - From: Novoseek, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Salbutamol Approved Pharma Partial agonist, Agonist 0
calcium Nutra 0

(28) Additional Compounds for DUSP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUSP1: view

Transcripts for DUSP1 Gene

mRNA/cDNA for DUSP1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(622) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP1 Gene

Dual specificity phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -
SP4:

Relevant External Links for DUSP1 Gene

GeneLoc Exon Structure for
DUSP1
ECgene alternative splicing isoforms for
DUSP1

Expression for DUSP1 Gene

mRNA expression in normal human tissues for DUSP1 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP1 Gene

This gene is overexpressed in Whole Blood (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP1 Gene



SOURCE GeneReport for Unigene cluster for DUSP1 Gene Hs.171695

mRNA Expression by UniProt/SwissProt for DUSP1 Gene

P28562-DUS1_HUMAN
Tissue specificity: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.
genes like me logo Genes that share expression patterns with DUSP1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for DUSP1 Gene

Orthologs for DUSP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUSP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP1 35
  • 99.73 (n)
  • 100 (a)
DUSP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP1 36
  • 97 (a)
OneToOne
DUSP1 35
  • 92.82 (n)
  • 96.73 (a)
dog
(Canis familiaris)
Mammalia DUSP1 35
  • 84.83 (n)
  • 83.38 (a)
DUSP1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp1 16
Dusp1 35
  • 90.19 (n)
  • 96.46 (a)
Dusp1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp1 35
  • 89.55 (n)
  • 97 (a)
chicken
(Gallus gallus)
Aves DUSP1 35
  • 80.37 (n)
  • 83.84 (a)
DUSP1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp1 35
  • 70.59 (n)
  • 79.73 (a)
Str.6379 35
zebrafish
(Danio rerio)
Actinopterygii dusp1 36
  • 71 (a)
OneToOne
Dr.2413 35
dusp1 35
  • 68.53 (n)
  • 72.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPS1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5253 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for DUSP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP1 Gene

ENSEMBL:
Gene Tree for DUSP1 (if available)
TreeFam:
Gene Tree for DUSP1 (if available)

Paralogs for DUSP1 Gene

Paralogs for DUSP1 Gene

(8) SIMAP similar genes for DUSP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP1: view

Variants for DUSP1 Gene

Sequence variations from dbSNP and Humsavar for DUSP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_025201 -
VAR_025202 -
rs78081495 -- 172,768,060(+) AGGGA(C/T)TGGGT downstream-variant-500B
rs77348539 -- 172,768,236(+) AAAAA(A/C/T)CCCAA utr-variant-3-prime
rs149004705 -- 172,769,163(+) TACTT(C/G)AGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP1 Gene

Variant ID Type Subtype PubMed ID
dgv1873e1 CNV Complex 17122850
essv9266 CNV CNV 17122850
nsv883109 CNV Loss 21882294
nsv883110 CNV Loss 21882294
nsv883111 CNV Loss 21882294
dgv6370n71 CNV Loss 21882294

Variation tolerance for DUSP1 Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP1 Gene

HapMap Linkage Disequilibrium report
DUSP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP1 Gene

Disorders for DUSP1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for DUSP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vaccinia
amyotrophic lateral sclerosis 7
  • amyotrophic lateral sclerosis type 7
multiple cranial nerve palsy
  • multiple cranial nerve palsies
amyotrophic lateral sclerosis 9
  • amyotrophic lateral sclerosis type 9
glossopharyngeal nerve disease
  • glossopharyngeal nerve diseases
- elite association - COSMIC cancer census association via MalaCards
Search DUSP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUSP1

Genetic Association Database (GAD)
DUSP1
Human Genome Epidemiology (HuGE) Navigator
DUSP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP1
genes like me logo Genes that share disorders with DUSP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP1 Gene

Publications for DUSP1 Gene

  1. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. (PMID: 1406996) Keyes S.M. … Emslie E.A. (Nature 1992) 2 3 4 67
  2. Mitogen-activated protein kinase phosphatase-1 negatively regulates the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in A549 human lung epithelial cells. (PMID: 20089808) Turpeinen T. … Korhonen R. (J. Pharmacol. Exp. Ther. 2010) 3 23
  3. Angiotensin II signaling via type 2 receptors in a human model of vascular hyporeactivity: implications for hypertension. (PMID: 19797979) CalA^ L.A. … Pessina A.C. (J. Hypertens. 2010) 3 23
  4. Proteasomal inhibition upregulates the endogenous MAPK deactivator MKP-1 in human airway smooth muscle: mechanism of action and effect on cytokine secretion. (PMID: 20043958) Moutzouris J.P. … Ammit A.J. (Biochim. Biophys. Acta 2010) 3 23
  5. KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. (PMID: 19411256) Liu R. … Chen C. (J. Biol. Chem. 2009) 3 23

Products for DUSP1 Gene

Sources for DUSP1 Gene

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