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DUSP1 Gene

protein-coding   GIFtS: 69
GCID: GC05M172195

Dual Specificity Phosphatase 1


(Previous symbol: PTPN10)
  See DUSP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 11 2     MAP Kinase Phosphatase 12 3
PTPN101 2 3 5     HVH12
CL1002 3 5     Dual Specificity Protein Phosphatase 12
Dual Specificity Protein Phosphatase HVH12 3     Serine/Threonine Specific Protein Phosphatase2
Mitogen-Activated Protein Kinase Phosphatase 12 3     EC 3.1.3.163
Protein-Tyrosine Phosphatase CL1002 3     EC 3.1.3.483
MKP-12 3     VH13
MKP12 3     

External Ids:    HGNC: 30641   Entrez Gene: 18432   Ensembl: ENSG000001201297   OMIM: 6007145   UniProtKB: P285623   

Export aliases for DUSP1 gene to outside databases

Previous GC identifers: GC05M172450 GC05M172896 GC05M172130 GC05M172176 GC05M172127 GC05M167290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP1 Gene:
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It
specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine
phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase
encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic
phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the
concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it
suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an
important role in the human cellular response to environmental stress as well as in the negative regulation of
cellular proliferation. (provided by RefSeq, Jul 2008)

GeneCards Summary for DUSP1 Gene:
DUSP1 (dual specificity phosphatase 1) is a protein-coding gene. Diseases associated with DUSP1 include vaccinia. GO annotations related to this gene include protein tyrosine/threonine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562
Function: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and
'Tyr-185', regulating its activity during the meiotic cell cycle (By similarity)

Gene Wiki entry for DUSP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP1 gene promoter:
         CREB   Elk-1   Sp1   deltaCREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DUSP1 promoter sequence
   Search Chromatin IP Primers for DUSP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

DUSP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M172195:  view genomic region     (about GC identifiers)

Start:
172,195,093 bp from pter      End:
172,198,203 bp from pter
Size:
3,111 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 1  
Size: 367 amino acids; 39298 Da
Secondary accessions: D3DQL9 Q2V508

Explore the universe of human proteins at neXtProt for DUSP1: NX_P28562

Explore proteomics data for DUSP1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation (By
    similarity)1
  • Ubiquitination2 at Lys280
  • Modification sites at PhosphoSitePlus

  • See DUSP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004408.1  
    ENSEMBL proteins: 
     ENSP00000239223  

    DUSP1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DUSP1

     
    Search eBioscience for Proteins for DUSP1 

     
    antibodies-online proteins for DUSP1 (7 products) 

     
    antibodies-online peptides for DUSP1

    DUSP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DUSP1
    R&D Systems Antibodies for DUSP1 (MKP-1)
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    OriGene Antibodies for DUSP1
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    Novus Biologicals DUSP1 Antibodies
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    antibodies-online antibodies for DUSP1 (96 products) 

    DUSP1 Assay Products:

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    Cloud-Clone Corp. ELISAs for DUSP1
    Cloud-Clone Corp. CLIAs for DUSP1
    Search eBioscience for ELISAs for DUSP1 
    antibodies-online kits for DUSP1 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    Selected InterPro protein domains (see all 8):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR020417 Atypical_DUSP

    Graphical View of Domain Structure for InterPro Entry P28562

    ProtoNet protein and cluster: P28562

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with DUSP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS1_HUMAN, P28562
    Function: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and
    'Tyr-185', regulating its activity during the meiotic cell cycle (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Induction: By oxidative stress and heat shock

         Genatlas biochemistry entry for DUSP1:
    dual specificity (tyr/thr) phosphatase 1,reversing the activation of mitogen-activated protein (MAP) kinase
    family,vaccinia virus phosphatase VH1-like 1,induced by EGF,predominantly expressed in
    lung,placenta,pancreas,involved in signal transduction

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity TAS1406996
    GO:0005515protein binding IPI10617468
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0008330protein tyrosine/threonine phosphatase activity IEA--
         
    Find genes that share ontologies with DUSP1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DUSP1:
     Decreased focal adhesion (FA)   Decreased viability with pacli 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dusp1) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  muscle  nervous system  pigmentation  respiratory system 

    Find genes that share phenotypes with DUSP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DUSP1: Dusp1tm1Brv Dusp1tm1(KOMP)Wtsi

       genOway: Develop your customized and physiologically relevant rodent model for DUSP1

    miRNA
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    miRTarBase miRNAs that target DUSP1:
    hsa-mir-101-3p (MIRT005876), hsa-mir-26b-5p (MIRT028795)

    Block miRNA regulation of human, mouse, rat DUSP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DUSP1 (see all 29):
    hsa-let-7d hsa-miR-429 hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-miR-144 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDUSP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DUSP1
    Predesigned siRNA for gene silencing in human, mouse, rat DUSP1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: DUSP1 (NM_004417)
    Sino Biological Human cDNA Clone for DUSP1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS1_HUMAN, P28562: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    extracellular1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA7593328
    GO:0005654nucleoplasm IBA--
    GO:0005737cytoplasm IDA7593328

    Find genes that share ontologies with DUSP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DUSP1 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2ERK Signaling
    ERK Signaling0.61
    3Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    4TGF-Beta Pathway
    JNK Pathway0.51
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Aldosterone Signaling in Epithelial Cells0.47


    Find genes that share SuperPaths with DUSP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DUSP1
        ERK Signaling
    NTHi-Induced Signaling
    Aldosterone Signaling in Epithelial Cells
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for DUSP1
        Phosphatases
    MAP Kinase Signaling

    3 GeneGo (Thomson Reuters) Pathways for DUSP1
        Signal transduction Erk Interactions- Inhibition of Erk
    Transcription P53 signaling pathway
    Development EGFR signaling pathway

    Selected BioSystems Pathways for DUSP1 (see all 7)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    Direct p53 effectors
    Regulation of p38-alpha and p38-beta
    ATF-2 transcription factor network



    2 Kegg Pathways  (Kegg details for DUSP1):
        MAPK signaling pathway
    Serotonergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DUSP1 (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DUSP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DUSP1 (P285621, 2, 3 ENSP000002392234) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284821, 2, 3, ENSP000002158324EBI-975493,EBI-959949 MINT-8291556 MINT-8291551 MINT-8217047 I2D: score=6 STRING: ENSP00000215832
    SKP2Q133091, 3, ENSP000002742554EBI-975493,EBI-456291 I2D: score=4 STRING: ENSP00000274255
    UBBP0CG471, 3, ENSP000003046974EBI-975493,EBI-413034 I2D: score=3 STRING: ENSP00000304697
    MAPK9P459842, 3, ENSP000003214104MINT-8217423 I2D: score=2 STRING: ENSP00000321410
    JUNP054122, 3, ENSP000003602664MINT-8287203 I2D: score=1 STRING: ENSP00000360266
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity ISS--
    GO:0001706endoderm formation IBA--
    GO:0006470protein dephosphorylation IBA--
    GO:0006979response to oxidative stress TAS1406996
    GO:0007049cell cycle ----

    Find genes that share ontologies with DUSP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP1 (DUS1)

    3 HMDB Compounds for DUSP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for DUSP1 gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 100 95.9 82 7780739 (7), 8106404 (7), 8168826 (6), 8390041 (5) (see all 27)
    triptolide 74 21 19893732 (5), 19289102 (1), 19476641 (1), 19755862 (1) (see all 9)
    pd 98,059 61.9 14 9202001 (1), 10473620 (1), 16081065 (1), 10873641 (1) (see all 12)
    sodium orthovanadate 60.7 6 11278958 (2), 15242861 (1), 7585624 (1)
    dexamethasone 57.1 78 12391149 (6), 17513787 (5), 15476200 (4), 18652821 (4) (see all 26)
    sb 203580 53.2 6 19648110 (1), 11577072 (1), 9501207 (1), 11689710 (1) (see all 5)
    tyrosine 52.8 57 18434324 (3), 7780739 (2), 17207923 (2), 8390041 (2) (see all 24)
    ag 1478 51.9 5 19175673 (2), 16081869 (1)
    vanadate 50.9 11 12529177 (2), 19893732 (2), 12186877 (1), 7700643 (1) (see all 6)
    manumycin 48.5 3 12452012 (3)



    Find genes that share compounds with DUSP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DUSP1 gene: 
    NM_004417.3  

    Unigene Cluster for DUSP1:

    Dual specificity phosphatase 1
    Hs.171695  [show with all ESTs]
    Unigene Representative Sequence: NM_004417
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000239223(uc003mbu.2 uc003mbv.2)
    miRNA
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    hsa-let-7d hsa-miR-429 hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-miR-144 hsa-let-7a
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP1
      QuantiTect SYBR Green Assays in human, mouse, rat DUSP1
      QuantiFast Probe-based Assays in human, mouse, rat DUSP1

    Additional mRNA sequence: 

    AJ227912.1 AK298047.1 AK298658.1 AK299391.1 AK300487.1 AK304475.1 AK316321.1 BC022463.1 
    X68277.1 

    18 DOTS entries:

    DT.450715  DT.97854855  DT.101961185  DT.100878604  DT.100878597  DT.100878602  DT.95169301  DT.120864071 
    DT.120864104  DT.91667554  DT.100878599  DT.100878606  DT.95169300  DT.100878594  DT.100878596  DT.100878600 
    DT.120864086  DT.92049103 

    Selected AceView cDNA sequences (see all 622):

    AI674311 AI923677 BQ722472 BE856575 BM695010 AI497863 AI972380 AI885305 
    NM_004417 AI199628 BQ637272 AI671264 AA374155 AA488364 BM710062 BQ694319 
    CB268799 BX107375 BI834585 AA385080 BF358306 BI909181 AI831017 AI369288 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                          -                           
    SP2:                                                      
    SP3:                          -     -                     
    SP4:                                                      


    ECgene alternative splicing isoforms for DUSP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DUSP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGACATAC
    DUSP1 Expression
    About this image


    DUSP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
             Nucleus Pulposus
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
     
     Ovary (Reproductive System)
             Secondary follicles
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Brain (Nervous System)
             Cerebellum
    DUSP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171695

    UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562
    Tissue specificity: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the
    heart and skeletal muscle. Lower levels found in the brain and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DUSP1 (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DUSP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp11 , 5 dual specificity phosphatase 11, 5 90.19(n)1
    96.46(a)1
      17 (13.28 cM)5
    192521  NM_013642.31  NP_038670.11 
     265055905 
    chicken
    (Gallus gallus)
    Aves DUSP11 dual specificity phosphatase 1 80.37(n)
    83.84(a)
      374192  NM_001085359.1  NP_001078828.1 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP16
    dual specificity phosphatase 1
    81(a)
    1 ↔ 1
    2(124308379-124311065)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC055962.12   -- 76.55(n)    BC055962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.24132 Danio rerio mRNA similar to dual specificity phosphatase more 76.14(n)    BC045494.1 


    ENSEMBL Gene Tree for DUSP1 (if available)
    TreeFam Gene Tree for DUSP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUSP1 gene
    DUSP42  SSH22  DUSP52  DUSP102  DUSP62  SSH32  DUSP162  DUSP92  
    DUSP22  DUSP82  DUSP72  SSH12  
    8 SIMAP similar genes for DUSP1 using alignment to 1 protein entry:     DUS1_HUMAN:
    DUSP4    DUSP2    DUSP5    DUSP10    DUSP6    DUSP8
    DUSP7    DUSP9

    Find genes that share paralogs with DUSP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP1 (see all 190)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352654881,2
    C,F--172194628(-) AACTC-/TTGAGCAA 1 -- cds15Minor allele frequency- TTG:0.04NS 188
    rs1472747841,2
    C--172194728(+) GGAAGA/GCGACT 1 -- ds50010--------
    rs359167241,2
    C,F--172194757(-) TTTAAT/CACCCT 1 -- ds50016Minor allele frequency- C:0.02NS WA 308
    rs1898223371,2
    --172194852(+) TACAGA/GGCCGC 1 -- ds50010--------
    rs3223511,2
    C,F,A,H--172194873(+) ATGGGC/TAGACA 1 -- ds500125Minor allele frequency- T:0.27NS EA NA WA 3830
    rs2005876481,2
    --172194928(+) ATGAT-/ACTC  
            
    ACTTG
    1 -- ds50010--------
    rs2019650271,2
    C--172194932(+) TACTC-/ACTT  
            
    GTCTT
    1 -- ds50010--------
    rs780814951,2
    C--172195063(+) AGGGAC/TTGGGT 1 -- ds50010--------
    rs38054761,2
    C,F--172195092(+) AAAGCG/ATTGAA 1 -- ds500113Minor allele frequency- A:0.25NA NS WA CSA EA 558
    rs344127221,2
    C--172195133(-) TTTTTA/GTACAA 1 -- ut316Minor allele frequency- G:0.01NS WA 308

    HapMap Linkage Disequilibrium report for DUSP1 (172195093 - 172198203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DUSP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6370n71CNV Loss21882294
    nsv883110CNV Loss21882294
    nsv883111CNV Loss21882294
    nsv883109CNV Loss21882294
    essv9266CNV CNV17122850
    dgv1873e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600714    OMIM disorders: --

    1 disease for DUSP1:    
    About MalaCards
    vaccinia


    Find genes that share disorders with DUSP1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DUSP1 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 32.5 12 15640643 (3), 15569826 (1), 18495502 (1), 18508759 (1) (see all 8)
    tumors 29.7 49 8909245 (4), 15640643 (3), 12432554 (3), 9010448 (2) (see all 24)
    shock 27.1 17 15640643 (4), 12748284 (2), 15677475 (1), 7780739 (1) (see all 10)
    prostatic intraepithelial neoplasia 17.6 2 9645439 (1)
    hypertrophy 16.7 1 15313208 (1)
    ovarian cancer 16 4 18089824 (2), 19755862 (1), 19697705 (1)
    breast cancer 14.9 24 19417026 (6), 20111893 (2), 17483361 (2), 14695202 (2) (see all 9)
    cancer 13.4 14 18922965 (3), 15243131 (2), 15856297 (1), 11710837 (1) (see all 9)
    breast carcinoma 11.2 4 19417026 (1), 15448190 (1), 8909245 (1), 17483361 (1)
    inflammation 4.66 6 16387640 (2), 18922786 (1), 20043958 (1), 16317391 (1)

    Genetic Association Database (GAD): DUSP1
    Human Genome Epidemiology (HuGE) Navigator: DUSP1 (13 documents)

    Export disorders for DUSP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP1 gene, integrated from 10 sources (see all 386):
    (articles sorted by number of sources associating them with DUSP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. (PubMed id 1406996)1, 2, 3 Keyes S.M. and Emslie E.A. (Nature 1992)
    2. Isolation and characterization of a human dual specificity protein- tyrosine phosphatase gene. (PubMed id 8106404)1, 2, 9 Kwak S.P.... Dixon J.E. (J. Biol. Chem. 1994)
    3. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PubMed id 20805296)1, 4 Coulthard L.R....McDermott M.F. (Ann. Rheum. Dis. 2011)
    4. Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients. (PubMed id 20673984)1, 4 Jin Y....Williams L.K. (J. Allergy Clin. Immunol. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PubMed id 20689807)1, 4 Wang X....Bell D.A. (PLoS ONE 2010)
    7. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (PubMed id 19262425)1, 4 Bowes J.D....Barton A. (Pharmacogenet. Genomics 2009)
    8. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)1, 4 O'Doherty C....Vandenbroeck K. (Pharmacogenomics 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Association of homozygous deletion of the Humhv3005 and the VH3-30.3 genes with renal involvement in systemic lupus erythematosus. (PubMed id 12765304)1, 4 Cho M.L....Cho C.S. (Lupus 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1843 HGNC: 3064 AceView: DUSP1 Ensembl:ENSG00000120129 euGenes: HUgn1843
    ECgene: DUSP1 Kegg: 1843 H-InvDB: DUSP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUSP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/dusp1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DUSP1 gene:
    Search GeneIP for patents involving DUSP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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