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Aliases for DUS4L Gene

Aliases for DUS4L Gene

  • Dihydrouridine Synthase 4-Like (S. Cerevisiae) 2 3
  • Protein Similar To E.Coli Yhdg And R. Capsulatus NifR3 2 3
  • PP35 3 4
  • TRNA-Dihydrouridine(20a/20b) Synthase [NAD(P)+]-Like 3
  • TRNA-Dihydrouridine Synthase 4-Like 4
  • EC 1.3.1.- 4
  • DUS4 3

External Ids for DUS4L Gene

Previous GeneCards Identifiers for DUS4L Gene

  • GC07P106799
  • GC07P106991
  • GC07P107203
  • GC07P101565

Summaries for DUS4L Gene

GeneCards Summary for DUS4L Gene

DUS4L (Dihydrouridine Synthase 4-Like (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include flavin adenine dinucleotide binding and tRNA dihydrouridine synthase activity.

UniProtKB/Swiss-Prot for DUS4L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS4L Gene

Genomics for DUS4L Gene

Regulatory Elements for DUS4L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUS4L Gene

Start:
107,563,484 bp from pter
End:
107,578,523 bp from pter
Size:
15,040 bases
Orientation:
Plus strand

Genomic View for DUS4L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUS4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS4L Gene

Proteins for DUS4L Gene

  • Protein details for DUS4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95620-DUS4L_HUMAN
    Recommended name:
    tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
    Protein Accession:
    O95620
    Secondary Accessions:
    • B4DLX0
    • Q2NKK1

    Protein attributes for DUS4L Gene

    Size:
    317 amino acids
    Molecular mass:
    35816 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD00100.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};

    Alternative splice isoforms for DUS4L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUS4L Gene

Proteomics data for DUS4L Gene at MOPED

Post-translational modifications for DUS4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUS4L Gene

No data available for DME Specific Peptides for DUS4L Gene

Domains for DUS4L Gene

Protein Domains for DUS4L Gene

Suggested Antigen Peptide Sequences for DUS4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95620

UniProtKB/Swiss-Prot:

DUS4L_HUMAN :
  • O95620
Family:
  • Belongs to the Dus family. Dus4 subfamily.
genes like me logo Genes that share domains with DUS4L: view

No data available for Gene Families for DUS4L Gene

Function for DUS4L Gene

Molecular function for DUS4L Gene

UniProtKB/Swiss-Prot Function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS4L Gene

Gene Ontology (GO) - Molecular Function for DUS4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010181 FMN binding --
GO:0016491 oxidoreductase activity --
GO:0017150 tRNA dihydrouridine synthase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with DUS4L: view
genes like me logo Genes that share phenotypes with DUS4L: view

Animal Model Products

CRISPR Products

miRNA for DUS4L Gene

miRTarBase miRNAs that target DUS4L

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUS4L Gene

Localization for DUS4L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUS4L Gene COMPARTMENTS Subcellular localization image for DUS4L gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS4L Gene

Pathways for DUS4L Gene

SuperPathways for DUS4L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS4L: view

No data available for Pathways by source for DUS4L Gene

Compounds for DUS4L Gene

(2) HMDB Compounds for DUS4L Gene

Compound Synonyms Cas Number PubMed IDs
5,6-Dihydrouridine
  • 5,6-Dihydrouridine
5627-05-4
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
genes like me logo Genes that share compounds with DUS4L: view

Transcripts for DUS4L Gene

Unigene Clusters for DUS4L Gene

Dihydrouridine synthase 4-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUS4L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUS4L Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6:
SP7: - -
SP8: - - - - - -
SP9:

Relevant External Links for DUS4L Gene

GeneLoc Exon Structure for
DUS4L
ECgene alternative splicing isoforms for
DUS4L

Expression for DUS4L Gene

mRNA expression in normal human tissues for DUS4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUS4L Gene

SOURCE GeneReport for Unigene cluster for DUS4L Gene Hs.97627

genes like me logo Genes that share expressions with DUS4L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUS4L Gene

Orthologs for DUS4L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUS4L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUS4L 35
  • 99.79 (n)
  • 100 (a)
DUS4L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUS4L 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUS4L 35
  • 93.06 (n)
  • 93.69 (a)
DUS4L 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dus4l 35
  • 88.61 (n)
  • 90.51 (a)
Dus4l 16
Dus4l 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUS4L 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUS4L 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dus4l 35
  • 88.19 (n)
  • 90.19 (a)
chicken
(Gallus gallus)
Aves DUS4L 35
  • 78.33 (n)
  • 78.85 (a)
DUS4L 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUS4L 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dus4l 35
  • 75.24 (n)
  • 76.21 (a)
zebrafish
(Danio rerio)
Actinopterygii dus4l 35
  • 69.02 (n)
  • 70.47 (a)
dus4l 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002791 35
  • 51.76 (n)
  • 51.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10495 35
  • 49.45 (n)
  • 45.07 (a)
CG10495 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C45G9.2 35
  • 54.17 (n)
  • 49.29 (a)
C45G9.2 36
  • 49 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER075W 35
  • 47.75 (n)
  • 41.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS4 35
  • 50.39 (n)
  • 43.43 (a)
DUS4 36
  • 34 (a)
OneToOne
DUS4 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02959g 35
  • 50.72 (n)
  • 42.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC777.15 35
  • 52.6 (n)
  • 43.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for DUS4L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUS4L Gene

ENSEMBL:
Gene Tree for DUS4L (if available)
TreeFam:
Gene Tree for DUS4L (if available)

Paralogs for DUS4L Gene

Selected SIMAP similar genes for DUS4L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DUS4L: view

No data available for Paralogs for DUS4L Gene

Variants for DUS4L Gene

Sequence variations from dbSNP and Humsavar for DUS4L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs711442 -- 107,577,588(+) ATATA(C/T)ACTTT utr-variant-3-prime, nc-transcript-variant
rs1468335 -- 107,567,673(+) ctcga(C/T)cattt intron-variant
rs1468336 -- 107,567,805(+) gttcc(C/T)cacag intron-variant
rs3839819 -- 107,576,624(-) CCCCC(-/C)AATTA intron-variant
rs4730250 -- 107,567,250(+) TTTTA(A/G)AAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUS4L Gene

Variant ID Type Subtype PubMed ID
nsv888940 CNV Loss 21882294

Relevant External Links for DUS4L Gene

HapMap Linkage Disequilibrium report
DUS4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUS4L Gene

Disorders for DUS4L Gene

Relevant External Links for DUS4L

Genetic Association Database (GAD)
DUS4L
Human Genome Epidemiology (HuGE) Navigator
DUS4L
genes like me logo Genes that share disorders with DUS4L: view

No data available for UniProtKB/Swiss-Prot for DUS4L Gene

Publications for DUS4L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. (PMID: 21068099) Evangelou E. … Spector T.D. (Ann. Rheum. Dis. 2011) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for DUS4L Gene

Sources for DUS4L Gene

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