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Aliases for DUS4L Gene

Aliases for DUS4L Gene

  • Dihydrouridine Synthase 4 Like 2 3 5
  • Protein Similar To E.Coli Yhdg And R. Capsulatus NifR3 2 3
  • PP35 3 4
  • TRNA-Dihydrouridine(20a/20b) Synthase [NAD(P)+]-Like 3
  • Dihydrouridine Synthase 4-Like (S. Cerevisiae) 2
  • TRNA-Dihydrouridine Synthase 4-Like 4
  • EC 1.3.1.- 4
  • DUS4 3

External Ids for DUS4L Gene

Previous GeneCards Identifiers for DUS4L Gene

  • GC07P106799
  • GC07P106991
  • GC07P107203
  • GC07P101565

Summaries for DUS4L Gene

GeneCards Summary for DUS4L Gene

DUS4L (Dihydrouridine Synthase 4 Like) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and FMN binding.

UniProtKB/Swiss-Prot for DUS4L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS4L Gene

Genomics for DUS4L Gene

Regulatory Elements for DUS4L Gene

Enhancers for DUS4L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G107742 1.4 ENCODE dbSUPER 10.3 +181.0 181016 4.8 CREB3L1 DMAP1 YY1 ZNF143 SP3 TBX21 MEF2D ZNF585B GLIS1 NBN HBP1 LOC101927974 RPL7P32 CBLL1 SLC26A4 SLC26A4-AS1 COG5 DUS4L ENSG00000272072
GH07G107594 1.1 Ensembl ENCODE 10.4 +32.5 32485 3.7 PKNOX1 FEZF1 RFX5 GATA2 ZNF366 ZSCAN5C FOS CEBPB OVOL3 ZEB2 COG5 SLC26A4 SLC26A4-AS1 DUS4L PIR46022 ENSG00000238832
GH07G107593 0.6 ENCODE 10.2 +29.6 29600 0.1 CTCF MTA2 IKZF1 DPF2 RAD21 IKZF2 SLC26A4 SLC26A4-AS1 COG5 DUS4L PIR46022 ENSG00000272854
GH07G107591 0.6 ENCODE 10.2 +29.0 28959 1.0 CTCF MTA2 IKZF1 MNT DPF2 IKZF2 SLC26A4 SLC26A4-AS1 COG5 DUS4L PIR46022 ENSG00000272854
GH07G107609 0.2 ENCODE 10 +46.4 46410 0.4 COG5 SLC26A4 SLC26A4-AS1 DUS4L ENSG00000238832 GC07M107613
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUS4L on UCSC Golden Path with GeneCards custom track

Promoters for DUS4L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216583 416 1801 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for DUS4L Gene

Chromosome:
7
Start:
107,563,484 bp from pter
End:
107,578,523 bp from pter
Size:
15,040 bases
Orientation:
Plus strand

Genomic View for DUS4L Gene

Genes around DUS4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUS4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUS4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS4L Gene

Proteins for DUS4L Gene

  • Protein details for DUS4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95620-DUS4L_HUMAN
    Recommended name:
    tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
    Protein Accession:
    O95620
    Secondary Accessions:
    • B4DLX0
    • Q2NKK1

    Protein attributes for DUS4L Gene

    Size:
    317 amino acids
    Molecular mass:
    35816 Da
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD00100.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};

    Alternative splice isoforms for DUS4L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUS4L Gene

Post-translational modifications for DUS4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUS4L Gene

Domains & Families for DUS4L Gene

Protein Domains for DUS4L Gene

Suggested Antigen Peptide Sequences for DUS4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95620

UniProtKB/Swiss-Prot:

DUS4L_HUMAN :
  • Belongs to the Dus family. Dus4 subfamily.
Family:
  • Belongs to the Dus family. Dus4 subfamily.
genes like me logo Genes that share domains with DUS4L: view

No data available for Gene Families for DUS4L Gene

Function for DUS4L Gene

Molecular function for DUS4L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS4L Gene

Gene Ontology (GO) - Molecular Function for DUS4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0017150 tRNA dihydrouridine synthase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with DUS4L: view
genes like me logo Genes that share phenotypes with DUS4L: view

Animal Model Products

CRISPR Products

miRNA for DUS4L Gene

miRTarBase miRNAs that target DUS4L

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS4L Gene

Localization for DUS4L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUS4L gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS4L Gene

Pathways & Interactions for DUS4L Gene

SuperPathways for DUS4L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS4L: view

No data available for Pathways by source and SIGNOR curated interactions for DUS4L Gene

Drugs & Compounds for DUS4L Gene

(1) Drugs for DUS4L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for DUS4L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5,6-Dihydrouridine
  • 5,6-Dihydrouridine
  • Dihydro-1-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydro-1-beta-delta-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydrouridine
5627-05-4
genes like me logo Genes that share compounds with DUS4L: view

Transcripts for DUS4L Gene

Unigene Clusters for DUS4L Gene

Dihydrouridine synthase 4-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUS4L Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6:
SP7: - -
SP8: - - - - - -
SP9:

Relevant External Links for DUS4L Gene

GeneLoc Exon Structure for
DUS4L
ECgene alternative splicing isoforms for
DUS4L

Expression for DUS4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUS4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUS4L Gene

This gene is overexpressed in Placenta (52.3) and Fetal Brain (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUS4L Gene



Protein tissue co-expression partners for DUS4L Gene

NURSA nuclear receptor signaling pathways regulating expression of DUS4L Gene:

DUS4L

SOURCE GeneReport for Unigene cluster for DUS4L Gene:

Hs.97627

Evidence on tissue expression from TISSUES for DUS4L Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DUS4L: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUS4L Gene

Orthologs for DUS4L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUS4L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUS4L 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia DUS4L 34 35
  • 93.06 (n)
cow
(Bos Taurus)
Mammalia DUS4L 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dus4l 34 16 35
  • 88.61 (n)
rat
(Rattus norvegicus)
Mammalia Dus4l 34
  • 88.19 (n)
oppossum
(Monodelphis domestica)
Mammalia DUS4L 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUS4L 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUS4L 34 35
  • 78.33 (n)
lizard
(Anolis carolinensis)
Reptilia DUS4L 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dus4l 34
  • 75.24 (n)
zebrafish
(Danio rerio)
Actinopterygii dus4l 34 35
  • 69.02 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002791 34
  • 51.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10495 34 35
  • 49.45 (n)
worm
(Caenorhabditis elegans)
Secernentea C45G9.2 34 35
  • 54.17 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02959g 34
  • 50.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS4 34 35 37
  • 50.39 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER075W 34
  • 47.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC777.15 34
  • 52.6 (n)
Species where no ortholog for DUS4L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUS4L Gene

ENSEMBL:
Gene Tree for DUS4L (if available)
TreeFam:
Gene Tree for DUS4L (if available)

Paralogs for DUS4L Gene

(2) SIMAP similar genes for DUS4L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DUS4L: view

No data available for Paralogs for DUS4L Gene

Variants for DUS4L Gene

Sequence variations from dbSNP and Humsavar for DUS4L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs115371930 Likely benign 107,564,376(+) TATCT(C/G)TTCCA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs55840928 Likely benign 107,563,995(+) GGCTC(C/T)AGGCC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs73419464 Likely benign 107,563,926(+) GTCAG(C/T)AGCAG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs114481539 Uncertain significance 107,564,340(+) ACTCA(A/C/G/T)AAGAG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs145603444 Uncertain significance 107,564,494(+) GAAGT(A/C)TGAAC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DUS4L Gene

Variant ID Type Subtype PubMed ID
esv3614462 CNV gain 21293372
nsv608074 CNV loss 21841781

Variation tolerance for DUS4L Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUS4L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUS4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUS4L Gene

Disorders for DUS4L Gene

Relevant External Links for DUS4L

Genetic Association Database (GAD)
DUS4L
Human Genome Epidemiology (HuGE) Navigator
DUS4L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUS4L

No disorders were found for DUS4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUS4L Gene

Publications for DUS4L Gene

  1. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. (PMID: 21068099) Evangelou E. … Spector T.D. (Ann. Rheum. Dis. 2011) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for DUS4L Gene

Sources for DUS4L Gene

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