Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DUS4L Gene

protein-coding   GIFtS: 54
GCID: GC07P107203

Dihydrouridine Synthase 4-Like (S. Cerevisiae)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dihydrouridine Synthase 4-Like (S. Cerevisiae)1 2     TRNA-Dihydrouridine(20a/20b) Synthase [NAD(P)+]-Like2
Protein Similar To E.Coli Yhdg And R. Capsulatus NifR31 2     EC 1.3.1.-3
DUS42     pp353
PP352     TRNA-Dihydrouridine Synthase 4-Like3

External Ids:    HGNC: 215171   Entrez Gene: 110622   Ensembl: ENSG000001058657   UniProtKB: O956203   
ORGUL members:         

Export aliases for DUS4L gene to outside databases

Previous GC identifers: GC07P106799 GC07P106991 GC07P101565


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DUS4L Gene:
DUS4L (dihydrouridine synthase 4-like (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include tRNA dihydrouridine synthase activity and flavin adenine dinucleotide binding.

UniProtKB/Swiss-Prot: DUS4L_HUMAN, O95620
Function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUS4L gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   NCX/Ncx   Nkx3-1 v1   Tal-1beta   Gfi-1   E47   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DUS4L promoter sequence
   Search Chromatin IP Primers for DUS4L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUS4L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22-q31   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22-q31

DUS4L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUS4L gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P107203:  view genomic region     (about GC identifiers)

Start:
107,203,929 bp from pter      End:
107,218,968 bp from pter
Size:
15,040 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 106,565,521-106,580,056     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DUS4L_HUMAN, O95620 (See protein sequence)
Recommended Name: tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like  
Size: 317 amino acids; 35816 Da
Cofactor: FAD (By similarity)
Sequence caution: Sequence=AAD00100.1; Type=Frameshift; Positions=14;
Secondary accessions: B4DLX0 Q2NKK1
Alternative splicing: 2 isoforms:  O95620-1   O95620-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for DUS4L: NX_O95620

Explore proteomics data for DUS4L at MOPED


See DUS4L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001257348.1  NP_853559.1  

ENSEMBL proteins: 
 ENSP00000402887   ENSP00000265720   ENSP00000388904   ENSP00000388061   ENSP00000412739  
 ENSP00000399375   ENSP00000385274  

DUS4L Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for DUS4L
OriGene Custom MassSpec
OriGene Custom Protein Services for DUS4L
GenScript Custom Purified and Recombinant Proteins Services for DUS4L
Novus Biologicals DUS4L Protein
Novus Biologicals DUS4L Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for DUS4L

 
Search eBioscience for Proteins for DUS4L 

 
antibodies-online proteins for DUS4L (3 products) 

 
antibodies-online peptides for DUS4L

DUS4L Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for DUS4L
Novus Biologicals DUS4L Antibodies
Abcam antibodies for DUS4L
Cloud-Clone Corp. Antibodies for DUS4L
ThermoFisher Antibodies for DUS4L
antibodies-online antibodies for DUS4L (14 products) 

DUS4L Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DUS4L
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for DUS4L
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for DUS4L
Cloud-Clone Corp. CLIAs for DUS4L
Search eBioscience for ELISAs for DUS4L 
antibodies-online kits for DUS4L (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
3 InterPro protein domains:
 IPR013785 Aldolase_TIM
 IPR001269 tRNA_hU_synthase
 IPR018517 tRNA_hU_synthase_CS

Graphical View of Domain Structure for InterPro Entry O95620

ProtoNet protein and cluster: O95620

1 Blocks protein domain: IPB001269 Protein of unknown function UPF0034

UniProtKB/Swiss-Prot: DUS4L_HUMAN, O95620
Similarity: Belongs to the Dus family. Dus4 subfamily


Find genes that share domains with DUS4L           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: DUS4L_HUMAN, O95620
Function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By
similarity)

     Enzyme Number (IUBMB): EC 1.3.1.-1

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0010181FMN binding ----
GO:0016491oxidoreductase activity ----
GO:0017150tRNA dihydrouridine synthase activity IEA--
GO:0050660flavin adenine dinucleotide binding IEA--
     
Find genes that share ontologies with DUS4L           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for DUS4L:
 Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for DUS4L

miRNA
Products:
    
miRTarBase miRNAs that target DUS4L:
hsa-mir-124-3p (MIRT023098)

Block miRNA regulation of human, mouse, rat DUS4L using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate DUS4L:
hsa-miR-3671 hsa-miR-607 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-3148 hsa-miR-3921
SwitchGear 3'UTR luciferase reporter plasmidDUS4L 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DUS4L
Predesigned siRNA for gene silencing in human, mouse, rat DUS4L

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DUS4L

Clone
Products:
     
OriGene clones in human, mouse for DUS4L (see all 6)
OriGene ORF clones in mouse, rat for DUS4L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DUS4L (NM_181581)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUS4L
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUS4L

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DUS4L
Browse ESI BIO Cell Lines and PureStem Progenitors for DUS4L 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUS4L


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
extracellular1
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DUS4L
Interactions:

    Search GeneGlobe Interaction Network for DUS4L

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

Selected Interacting proteins for DUS4L (O956203 ENSP000002657204) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
InteractantInteraction Details
GeneCardExternal ID(s)
FANCAO153603, ENSP000003739524I2D: score=1 STRING: ENSP00000373952
METTL1Q9UBP63, ENSP000003144414I2D: score=1 STRING: ENSP00000314441
TOP1P113873, ENSP000003545224I2D: score=1 STRING: ENSP00000354522
BYSLQ138953I2D: score=1 
CCT6AP402273I2D: score=1 
About this table

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000105histidine biosynthetic process ----
GO:0008033tRNA processing ----
GO:0055114oxidation-reduction process ----

Find genes that share ontologies with DUS4L           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DUS4L

2 HMDB Compounds for DUS4L    About this table
CompoundSynonyms CAS #PubMed Ids
5,6-Dihydrouridine5,6-Dihydrouridine (see all 4)5627-05-4--
FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DUS4L gene (2 alternative transcripts): 
NM_001270419.1  NM_181581.2  

Unigene Cluster for DUS4L:

Dihydrouridine synthase 4-like (S. cerevisiae)
Hs.97627  [show with all ESTs]
Unigene Representative Sequence: NR_073002
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000498786 ENST00000422290 ENST00000265720(uc003veh.3 uc011klw.2 uc011klx.2 uc010ljl.3)
ENST00000431839 ENST00000443233 ENST00000436411(uc022ajw.1) ENST00000458611
ENST00000467916 ENST00000471763 ENST00000497798 ENST00000485825 ENST00000402620

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DUS4L using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate DUS4L:
hsa-miR-3671 hsa-miR-607 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-3148 hsa-miR-3921
SwitchGear 3'UTR luciferase reporter plasmidDUS4L 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DUS4L
Predesigned siRNA for gene silencing in human, mouse, rat DUS4L
Clone
Products:
     
OriGene clones in human, mouse for DUS4L (see all 6)
OriGene ORF clones in mouse, rat for DUS4L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DUS4L (NM_181581)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUS4L
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUS4L
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DUS4L
OriGene qSTAR qPCR primer pairs in human, mouse for DUS4L
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUS4L
  QuantiTect SYBR Green Assays in human, mouse, rat DUS4L
  QuantiFast Probe-based Assays in human, mouse, rat DUS4L

Additional mRNA sequence: 

AK294095.1 AK297195.1 AK308472.1 NR_073002.1 NR_073003.1 NR_073004.1 NR_073005.1 U62767.1 

12 DOTS entries:

DT.110148  DT.121102930  DT.100877360  DT.121103182  DT.100877354  DT.40119094  DT.91748830  DT.100667358 
DT.100723879  DT.102836929  DT.70102487  DT.91706089 

Selected AceView cDNA sequences (see all 72):

CR605496 AI378669 BX504337 AI275853 NM_181581 BQ771928 AI609138 BG250736 
CR625341 CA428914 AW163754 AW157722 CR602101 AV718761 AV714249 BU621752 
AL523141 AI522040 CB851456 BX357552 H59368 BP375403 AI679397 BX356318 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DUS4L (see all 9)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b
SP1:                          -     -                       -     -                 -     -                                             
SP2:                                -                       -                       -     -                                             
SP3:                                -                       -     -           -     -     -                                             
SP4:                                                        -     -           -     -     -                                             
SP5:                                -                                                                                                   


ECgene alternative splicing isoforms for DUS4L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DUS4L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CACTGCAAGA
DUS4L Expression
About this image


DUS4L expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Limb (Muscoskeletal System)
         Limb Muscle Progenitor Cells Forelimb Myotome
 
 Skeletal Muscle (Muscoskeletal System)
         Limb Muscle Progenitor Cells Forelimb Myotome
DUS4L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DUS4L Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.97627
    Custom PCR Arrays for DUS4L
Primer
Products:
OriGene qPCR primer pairs and template standards for DUS4L
OriGene qSTAR qPCR primer pairs in human, mouse for DUS4L
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUS4L
QuantiTect SYBR Green Assays in human, mouse, rat DUS4L
QuantiFast Probe-based Assays in human, mouse, rat DUS4L
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUS4L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUS4L gene from Selected species (see all 22)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dus4l1 , 5 dihydrouridine synthase 4-like (S. cerevisiae)1, 5 88.61(n)1
90.51(a)1
  12 (13.68 cM)5
719161  NM_028002.21  NP_082278.11 
 316400555 
chicken
(Gallus gallus)
Aves DUS4L1 dihydrouridine synthase 4-like (S. cerevisiae) 78.33(n)
78.85(a)
  769352  XM_001231914.3  XP_001231915.2 
lizard
(Anolis carolinensis)
Reptilia DUS4L6
dihydrouridine synthase 4-like (S. cerevisiae)
74(a)
1 ↔ 1
5(97612290-97622050)
African clawed frog
(Xenopus laevis)
Amphibia BU913916.12   -- 76.91(n)    BU913916.1 
zebrafish
(Danio rerio)
Actinopterygii dus4l1 dihydrouridine synthase 4-like (S. cerevisiae) 69.02(n)
70.47(a)
  445096  NM_001003490.2  NP_001003490.2 
fruit fly
(Drosophila melanogaster)
Insecta CG104951 CG10495 49.45(n)
45.07(a)
  35179  NM_136095.3  NP_609939.1 
worm
(Caenorhabditis elegans)
Secernentea C45G9.21 C45G9.2 54.17(n)
49.29(a)
  183479  NM_065677.6  NP_498078.2 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS4(YLR405W)4
DUS41
Dihydrouridine synthase, member of a widespread family more4
DUS41
50.39(n)1
43.43(a)1
  12(929789-930892)4
8511211, 4  NP_013509.11, 4 


ENSEMBL Gene Tree for DUS4L (if available)
TreeFam Gene Tree for DUS4L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for DUS4L gene
2 SIMAP similar genes for DUS4L using alignment to 4 protein entries:     DUS4L_HUMAN (see all proteins):
PP35    DUS1L

Find genes that share paralogs with DUS4L           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for DUS4L (see all 210)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs102730851,2
C,F,H--107207090(+) AACTTT/ACCTGA 6 -- int14Minor allele frequency- A:0.00NS EA 404
rs1922108161,2
--107207094(+) TTCCTA/GAATAA 6 -- int10--------
rs777317941,2
--107207227(+) ACATGC/GTAAAC 6 -- int10--------
rs58864191,2
C--107207237(+) AAAAA-/ATCTCG 6 -- int1 trp30--------
rs1155832201,2
F--107207253(+) AATCTC/TGTTTT 6 -- int11Minor allele frequency- T:0.05WA 118
rs1421481751,2
--107207300(+) TTCCAC/TATCTA 6 -- int10--------
rs1173258891,2
C,F--107207410(+) AAATAT/CATGTT 6 -- int11Minor allele frequency- C:0.03NA 120
rs2014669961,2
C--107207539(+) CAAACA/GACAAT 8 T syn10--------
rs1995106741,2
F--107207597(+) AGCTGG/ATAAAA 8 /I /V mis11Minor allele frequency- A:0.00EU 1321
rs2006810461,2
C--107207639(+) AAGTGC/TTGCAA 6 -- int10--------

HapMap Linkage Disequilibrium report for DUS4L (107203929 - 107218968 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for DUS4L:    About this table    
Variant IDTypeSubtypePubMed ID
nsv888940CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DUS4L
DNA2.0 Custom Variant and Variant Library Synthesis for DUS4L

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

Find genes that share disorders with DUS4L           About GenesLikeMe

Genetic Association Database (GAD): DUS4L
Human Genome Epidemiology (HuGE) Navigator: DUS4L (2 documents)

Export disorders for DUS4L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DUS4L gene integrated from 10 sources:
(articles sorted by number of sources associating them with DUS4L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. (PubMed id 21068099)1, 4 Evangelou E....Spector T.D. (Ann. Rheum. Dis. 2011)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (Science 2003)
  7. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. (PubMed id 14499622)1 Reuter T.Y....Huber P.A. (Exp. Cell Res. 2003)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (Genome Res. 1996)
  10. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 11062 HGNC: 21517 AceView: PP35 Ensembl:ENSG00000105865 euGenes: HUgn11062
ECgene: DUS4L H-InvDB: DUS4L

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for DUS4L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for DUS4L gene:
Search GeneIP for patents involving DUS4L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DUS4L  
 OriGene qPCR primer pairs and template standards for DUS4L   OriGene Protein Over-expression Lysate for DUS4L  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for DUS4L  
 OriGene qSTAR qPCR primer pairs in human, mouse for DUS4L   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for DUS4L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DUS4L   OriGene Custom Protein Services for DUS4L  

 
 
 Block miRNA regulation of human, mouse, rat DUS4L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DUS4L
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUS4L Predesigned siRNA for gene silencing in human, mouse, rat DUS4L
 QuantiFast Probe-based Assays in human, mouse, rat DUS4L QuantiTect SYBR Green Assays in human, mouse, rat DUS4L
 Custom PCR Arrays for DUS4L Search Chromatin IP Primers for DUS4L
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUS4L  Search GeneGlobe Interaction Network for DUS4L
 Regulatory tfbs in DUS4L promoter
 GenScript Custom Purified and Recombinant Proteins Services for DUS4L GenScript cDNA clones with any tag delivered in your preferred vector for DUS4L
 GenScript Custom Assay Services for DUS4L GenScript Custom overexpressing Cell Line Services for DUS4L
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for DUS4L
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 DUS4L antibodies
 DUS4L proteins
 DUS4L lysates
 Antibodies for DUS4L
 See all of Abcam's Antibodies, Kits and Proteins for DUS4L
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for DUS4L
 Antibodies for DUS4L
 ELISAs for DUS4L
 CLIAs for DUS4L



 Browse ESI BIO Cell Lines and PureStem Progenitors for DUS4L
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUS4L
 SwitchGear 3'UTR luciferase reporter plasmids for DUS4L
 SwitchGear Promoter luciferase reporter plasmids for DUS4L
 ThermoFisher Antibodies for DUS4L
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUS4L
 Browse compounds at ApexBio
 Search Addgene for plasmids for DUS4L
  Search eBioscience for proteins for DUS4L
  Search eBioscience for elisas for DUS4L
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for DUS4L
 antibodies-online antibodies for DUS4L (14 products)
 antibodies-online kits for DUS4L (4 products)
 antibodies-online peptides for DUS4L
 antibodies-online proteins for DUS4L (3 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DUS4L gene at Home site.
Version: 3.12.250 16 Nov 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4