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Aliases for DUS3L Gene

Aliases for DUS3L Gene

  • Dihydrouridine Synthase 3 Like 2 3
  • Dihydrouridine Synthase 3-Like 3 5
  • Dihydrouridine Synthase 3-Like (S. Cerevisiae) 2
  • TRNA-Dihydrouridine Synthase 3-Like 4
  • EC 1.3.1.- 4
  • DUS3 3

External Ids for DUS3L Gene

Previous GeneCards Identifiers for DUS3L Gene

  • GC19M005737
  • GC19M005546

Summaries for DUS3L Gene

GeneCards Summary for DUS3L Gene

DUS3L (Dihydrouridine Synthase 3 Like) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and tRNA dihydrouridine synthase activity. An important paralog of this gene is ENSG00000267157.

UniProtKB/Swiss-Prot for DUS3L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS3L Gene

Genomics for DUS3L Gene

Regulatory Elements for DUS3L Gene

Enhancers for DUS3L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DUS3L on UCSC Golden Path with GeneCards custom track

Promoters for DUS3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUS3L on UCSC Golden Path with GeneCards custom track

Genomic Location for DUS3L Gene

5,784,832 bp from pter
5,791,238 bp from pter
6,407 bases
Minus strand

Genomic View for DUS3L Gene

Genes around DUS3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUS3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUS3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS3L Gene

Proteins for DUS3L Gene

  • Protein details for DUS3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
    Protein Accession:
    Secondary Accessions:
    • Q96HM5
    • Q9BSU4
    • Q9H877
    • Q9NPR1

    Protein attributes for DUS3L Gene

    650 amino acids
    Molecular mass:
    72594 Da
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DUS3L Gene


neXtProt entry for DUS3L Gene

Proteomics data for DUS3L Gene at MOPED

Post-translational modifications for DUS3L Gene

  • Ubiquitination at Lys 134, Lys 306, Lys 416, Lys 435, and Lys 526
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DUS3L Gene

Domains & Families for DUS3L Gene

Suggested Antigen Peptide Sequences for DUS3L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Dus family. Dus3 subfamily.
  • Contains 2 C3H1-type zinc fingers.
  • Belongs to the Dus family. Dus3 subfamily.
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with DUS3L: view

No data available for Gene Families for DUS3L Gene

Function for DUS3L Gene

Molecular function for DUS3L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS3L Gene

Gene Ontology (GO) - Molecular Function for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DUS3L: view
genes like me logo Genes that share phenotypes with DUS3L: view

Animal Model Products

miRNA for DUS3L Gene

miRTarBase miRNAs that target DUS3L

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS3L Gene

Localization for DUS3L Gene

Subcellular locations from

Jensen Localization Image for DUS3L Gene COMPARTMENTS Subcellular localization image for DUS3L gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS3L Gene

Pathways & Interactions for DUS3L Gene

SuperPathways for DUS3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS3L: view

No data available for Pathways by source and SIGNOR curated interactions for DUS3L Gene

Drugs & Compounds for DUS3L Gene

(1) Drugs for DUS3L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for DUS3L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5,6-Dihydrouridine
  • Dihydro-1-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydro-1-beta-delta-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydrouridine
genes like me logo Genes that share compounds with DUS3L: view

Transcripts for DUS3L Gene

Unigene Clusters for DUS3L Gene

Dihydrouridine synthase 3-like (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUS3L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: -
SP2: - - - - - -
SP3: - - - -
SP4: - - - -
SP5: -

Relevant External Links for DUS3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUS3L Gene

mRNA expression in normal human tissues for DUS3L Gene

Protein differential expression in normal tissues from HIPED for DUS3L Gene

This gene is overexpressed in Testis (12.5), Peripheral blood mononuclear cells (10.1), Breast (7.6), Blymphocyte (7.1), Pancreas (6.6), and Lung (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUS3L Gene

SOURCE GeneReport for Unigene cluster for DUS3L Gene Hs.284297

genes like me logo Genes that share expression patterns with DUS3L: view

Protein tissue co-expression partners for DUS3L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUS3L Gene

Orthologs for DUS3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS3L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUS3L 35
  • 85.35 (n)
  • 86.53 (a)
DUS3L 36
  • 86 (a)
(Canis familiaris)
Mammalia DUS3L 35
  • 86.35 (n)
  • 87.38 (a)
DUS3L 36
  • 86 (a)
(Mus musculus)
Mammalia Dus3l 35
  • 81.18 (n)
  • 83.98 (a)
Dus3l 16
Dus3l 36
  • 83 (a)
(Pan troglodytes)
Mammalia DUS3L 35
  • 94.44 (n)
  • 93.86 (a)
DUS3L 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dus3l 35
  • 79.17 (n)
  • 82.97 (a)
(Monodelphis domestica)
Mammalia DUS3L 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia DUS3L 36
  • 65 (a)
(Gallus gallus)
Aves DUS3L 35
  • 68.18 (n)
  • 68.93 (a)
DUS3L 36
  • 66 (a)
(Anolis carolinensis)
Reptilia DUS3L 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dus3l 35
  • 63.55 (n)
  • 70.49 (a)
MGC76275 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53781 35
(Danio rerio)
Actinopterygii dus3l 35
  • 67.21 (n)
  • 66.89 (a)
zgc63779 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4216 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009171 35
  • 55.96 (n)
  • 48.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10463 35
  • 54.59 (n)
  • 48.32 (a)
CG10463 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea Y37E11B.5 35
  • 53.79 (n)
  • 54.96 (a)
Y37E11B.5 36
  • 50 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER070C 35
  • 56.59 (n)
  • 43.77 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03069g 35
  • 45.05 (n)
  • 38.66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS3 35
  • 47.53 (n)
  • 40.84 (a)
DUS3 36
  • 34 (a)
DUS3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G38890 35
  • 51.3 (n)
  • 50.29 (a)
(Oryza sativa)
Liliopsida Os.7618 35
Os04g0117600 35
  • 52.97 (n)
  • 53.78 (a)
(Triticum aestivum)
Liliopsida Ta.25338 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2732 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02619 35
  • 56.03 (n)
  • 45.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dus3 35
  • 45.18 (n)
  • 39.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8801 36
  • 57 (a)
Species with no ortholog for DUS3L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DUS3L Gene

Gene Tree for DUS3L (if available)
Gene Tree for DUS3L (if available)

Paralogs for DUS3L Gene

Paralogs for DUS3L Gene

genes like me logo Genes that share paralogs with DUS3L: view

Variants for DUS3L Gene

Sequence variations from dbSNP and Humsavar for DUS3L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2436487 - 5,789,554(-) ACCTG(A/G)GGCCC intron-variant, nc-transcript-variant, reference, missense
VAR_027093 -
rs12977448 -- 5,787,229(+) GGTGG(C/G)AGGTG intron-variant
rs7508740 -- 5,792,038(+) gtgtg(C/G/T)tggct upstream-variant-2KB
rs8101416 -- 5,792,463(+) TCGGA(A/T)ACACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DUS3L Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
dgv3694n71 CNV Loss 21882294
nsv470119 CNV Loss 18288195
nsv525707 CNV Loss 19592680
dgv3696n71 CNV Loss 21882294
nsv910901 CNV Loss 21882294
nsv817812 CNV Loss 17921354
esv1024134 CNV Insertion 17803354
esv1693395 CNV Insertion 17803354

Variation tolerance for DUS3L Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.81; 91.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DUS3L Gene

Disorders for DUS3L Gene

Relevant External Links for DUS3L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DUS3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUS3L Gene

Publications for DUS3L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar F.J. … Moffat J. (Mol. Syst. Biol. 2013) 3

Products for DUS3L Gene

Sources for DUS3L Gene