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Aliases for DUS3L Gene

Aliases for DUS3L Gene

  • Dihydrouridine Synthase 3-Like (S. Cerevisiae) 2 3
  • TRNA-Dihydrouridine(47) Synthase [NAD(P)(+)]-Like 3
  • TRNA-Dihydrouridine Synthase 3-Like 4
  • EC 1.3.1.- 4
  • DUS3 3

External Ids for DUS3L Gene

Previous GeneCards Identifiers for DUS3L Gene

  • GC19M005737
  • GC19M005546

Summaries for DUS3L Gene

GeneCards Summary for DUS3L Gene

DUS3L (Dihydrouridine Synthase 3-Like (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include flavin adenine dinucleotide binding and tRNA dihydrouridine synthase activity. An important paralog of this gene is ENSG00000267157.

UniProtKB/Swiss-Prot for DUS3L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS3L Gene

Genomics for DUS3L Gene

Regulatory Elements for DUS3L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUS3L Gene

Start:
5,784,832 bp from pter
End:
5,791,238 bp from pter
Size:
6,407 bases
Orientation:
Minus strand

Genomic View for DUS3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUS3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS3L Gene

Proteins for DUS3L Gene

  • Protein details for DUS3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G46-DUS3L_HUMAN
    Recommended name:
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
    Protein Accession:
    Q96G46
    Secondary Accessions:
    • Q96HM5
    • Q9BSU4
    • Q9H877
    • Q9NPR1

    Protein attributes for DUS3L Gene

    Size:
    650 amino acids
    Molecular mass:
    72594 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DUS3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUS3L Gene

Proteomics data for DUS3L Gene at MOPED

Post-translational modifications for DUS3L Gene

  • Ubiquitination at Lys134, Lys306, Lys416, Lys435, and Lys526
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DUS3L Gene

Domains for DUS3L Gene

Suggested Antigen Peptide Sequences for DUS3L Gene

Graphical View of Domain Structure for InterPro Entry

Q96G46

UniProtKB/Swiss-Prot:

DUS3L_HUMAN :
  • Q96G46
Family:
  • Belongs to the Dus family. Dus3 subfamily.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with DUS3L: view

No data available for Gene Families for DUS3L Gene

Function for DUS3L Gene

Molecular function for DUS3L Gene

UniProtKB/Swiss-Prot Function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS3L Gene

Gene Ontology (GO) - Molecular Function for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017150 tRNA dihydrouridine synthase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0046872 metal ion binding IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with DUS3L: view

Phenotypes for DUS3L Gene

GenomeRNAi human phenotypes for DUS3L:
genes like me logo Genes that share phenotypes with DUS3L: view

Animal Model Products

CRISPR Products

miRNA for DUS3L Gene

miRTarBase miRNAs that target DUS3L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUS3L

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUS3L Gene

Localization for DUS3L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUS3L Gene COMPARTMENTS Subcellular localization image for DUS3L gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS3L Gene

Pathways for DUS3L Gene

SuperPathways for DUS3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS3L: view

No data available for Pathways by source for DUS3L Gene

Compounds for DUS3L Gene

(2) HMDB Compounds for DUS3L Gene

Compound Synonyms Cas Number PubMed IDs
5,6-Dihydrouridine
  • 5,6-Dihydrouridine
5627-05-4
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
genes like me logo Genes that share compounds with DUS3L: view

Transcripts for DUS3L Gene

Unigene Clusters for DUS3L Gene

Dihydrouridine synthase 3-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUS3L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUS3L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: -
SP2: - - - - - -
SP3: - - - -
SP4: - - - -
SP5: -
SP6:
SP7:

Relevant External Links for DUS3L Gene

GeneLoc Exon Structure for
DUS3L
ECgene alternative splicing isoforms for
DUS3L

Expression for DUS3L Gene

mRNA expression in normal human tissues for DUS3L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUS3L Gene

SOURCE GeneReport for Unigene cluster for DUS3L Gene Hs.284297

genes like me logo Genes that share expressions with DUS3L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUS3L Gene

Orthologs for DUS3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUS3L 35
  • 94.44 (n)
  • 93.86 (a)
DUS3L 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUS3L 35
  • 85.35 (n)
  • 86.53 (a)
DUS3L 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUS3L 35
  • 86.35 (n)
  • 87.38 (a)
DUS3L 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dus3l 35
  • 81.18 (n)
  • 83.98 (a)
Dus3l 16
Dus3l 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUS3L 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUS3L 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dus3l 35
  • 79.17 (n)
  • 82.97 (a)
chicken
(Gallus gallus)
Aves DUS3L 35
  • 68.18 (n)
  • 68.93 (a)
DUS3L 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUS3L 36
  • 45 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53781 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dus3l 35
  • 63.55 (n)
  • 70.49 (a)
MGC76275 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4216 35
zebrafish
(Danio rerio)
Actinopterygii dus3l 35
  • 67.21 (n)
  • 66.89 (a)
zgc63779 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009171 35
  • 55.96 (n)
  • 48.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10463 35
  • 54.59 (n)
  • 48.32 (a)
CG10463 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y37E11B.5 35
  • 53.79 (n)
  • 54.96 (a)
Y37E11B.5 36
  • 50 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER070C 35
  • 56.59 (n)
  • 43.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS3 35
  • 47.53 (n)
  • 40.84 (a)
DUS3 36
  • 34 (a)
OneToMany
DUS3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03069g 35
  • 45.05 (n)
  • 38.66 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G38890 35
  • 51.3 (n)
  • 50.29 (a)
rice
(Oryza sativa)
Liliopsida Os.7618 35
Os04g0117600 35
  • 52.97 (n)
  • 53.78 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.25338 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02619 35
  • 56.03 (n)
  • 45.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dus3 35
  • 45.18 (n)
  • 39.78 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2732 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8801 36
  • 57 (a)
OneToMany
Species with no ortholog for DUS3L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DUS3L Gene

ENSEMBL:
Gene Tree for DUS3L (if available)
TreeFam:
Gene Tree for DUS3L (if available)

Paralogs for DUS3L Gene

Paralogs for DUS3L Gene

genes like me logo Genes that share paralogs with DUS3L: view

Variants for DUS3L Gene

Sequence variations from dbSNP and Humsavar for DUS3L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10811 -- 5,786,804(+) CAGTC(A/G)GCTAG reference, synonymous-codon, nc-transcript-variant
rs1046049 -- 5,786,817(-) GCGCT(A/G)CACCA reference, missense, nc-transcript-variant
rs1128792 -- 5,786,890(-) TCTGC(A/G)TCTCA intron-variant, nc-transcript-variant
rs2290776 -- 5,791,156(-) AGCGG(A/C/G)TGTGA utr-variant-5-prime, nc-transcript-variant
rs2290777 -- 5,790,700(-) CGAGT(A/G)CCGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUS3L Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
dgv3694n71 CNV Loss 21882294
nsv470119 CNV Loss 18288195
nsv525707 CNV Loss 19592680
dgv3696n71 CNV Loss 21882294
nsv910901 CNV Loss 21882294
nsv817812 CNV Loss 17921354
esv1024134 CNV Insertion 17803354
esv1693395 CNV Insertion 17803354

Relevant External Links for DUS3L Gene

HapMap Linkage Disequilibrium report
DUS3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUS3L Gene

Disorders for DUS3L Gene

No disorders were found for DUS3L Gene.

No data available for UniProtKB/Swiss-Prot for DUS3L Gene

Publications for DUS3L Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Purification and identification of endogenous polySUMO conjugates. (PMID: 21252943) Bruderer R. … Hay R.T. (EMBO Rep. 2011) 3

Products for DUS3L Gene

Sources for DUS3L Gene

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