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Aliases for DUS3L Gene

Aliases for DUS3L Gene

  • Dihydrouridine Synthase 3 Like 2 3 5
  • TRNA-Dihydrouridine(47) Synthase [NAD(P)(+)]-Like 3
  • Dihydrouridine Synthase 3-Like (S. Cerevisiae) 2
  • TRNA-Dihydrouridine Synthase 3-Like 4
  • EC 1.3.1.- 4
  • DUS3 3

External Ids for DUS3L Gene

Previous GeneCards Identifiers for DUS3L Gene

  • GC19M005737
  • GC19M005546

Summaries for DUS3L Gene

GeneCards Summary for DUS3L Gene

DUS3L (Dihydrouridine Synthase 3 Like) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and tRNA dihydrouridine synthase activity. An important paralog of this gene is ENSG00000267157.

UniProtKB/Swiss-Prot for DUS3L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS3L Gene

Genomics for DUS3L Gene

Regulatory Elements for DUS3L Gene

Enhancers for DUS3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DUS3L on UCSC Golden Path with GeneCards custom track

Promoters for DUS3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUS3L on UCSC Golden Path with GeneCards custom track

Genomic Location for DUS3L Gene

Chromosome:
19
Start:
5,784,832 bp from pter
End:
5,791,238 bp from pter
Size:
6,407 bases
Orientation:
Minus strand

Genomic View for DUS3L Gene

Genes around DUS3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUS3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUS3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS3L Gene

Proteins for DUS3L Gene

  • Protein details for DUS3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G46-DUS3L_HUMAN
    Recommended name:
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
    Protein Accession:
    Q96G46
    Secondary Accessions:
    • Q96HM5
    • Q9BSU4
    • Q9H877
    • Q9NPR1

    Protein attributes for DUS3L Gene

    Size:
    650 amino acids
    Molecular mass:
    72594 Da
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DUS3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUS3L Gene

Post-translational modifications for DUS3L Gene

  • Ubiquitination at Lys 134, Lys 306, Lys 416, Lys 435, and Lys 526
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DUS3L Gene

Domains & Families for DUS3L Gene

Suggested Antigen Peptide Sequences for DUS3L Gene

Graphical View of Domain Structure for InterPro Entry

Q96G46

UniProtKB/Swiss-Prot:

DUS3L_HUMAN :
  • Belongs to the Dus family. Dus3 subfamily.
  • Contains 2 C3H1-type zinc fingers.
Family:
  • Belongs to the Dus family. Dus3 subfamily.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with DUS3L: view

No data available for Gene Families for DUS3L Gene

Function for DUS3L Gene

Molecular function for DUS3L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS3L Gene

Gene Ontology (GO) - Molecular Function for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017150 tRNA dihydrouridine synthase activity IBA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0046872 metal ion binding IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with DUS3L: view
genes like me logo Genes that share phenotypes with DUS3L: view

Animal Model Products

CRISPR Products

miRNA for DUS3L Gene

miRTarBase miRNAs that target DUS3L

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS3L Gene

Localization for DUS3L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUS3L Gene COMPARTMENTS Subcellular localization image for DUS3L gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with DUS3L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DUS3L Gene

Pathways & Interactions for DUS3L Gene

SuperPathways for DUS3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS3L: view

No data available for Pathways by source and SIGNOR curated interactions for DUS3L Gene

Drugs & Compounds for DUS3L Gene

(1) Drugs for DUS3L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for DUS3L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5,6-Dihydrouridine
  • 5,6-Dihydrouridine
  • Dihydro-1-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydro-1-beta-delta-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydrouridine
5627-05-4
genes like me logo Genes that share compounds with DUS3L: view

Transcripts for DUS3L Gene

Unigene Clusters for DUS3L Gene

Dihydrouridine synthase 3-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUS3L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: -
SP2: - - - - - -
SP3: - - - -
SP4: - - - -
SP5: -
SP6:
SP7:

Relevant External Links for DUS3L Gene

GeneLoc Exon Structure for
DUS3L
ECgene alternative splicing isoforms for
DUS3L

Expression for DUS3L Gene

mRNA expression in normal human tissues for DUS3L Gene

Protein differential expression in normal tissues from HIPED for DUS3L Gene

This gene is overexpressed in Testis (12.5), Peripheral blood mononuclear cells (10.1), Breast (7.6), Blymphocyte (7.1), Pancreas (6.6), and Lung (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUS3L Gene



Protein tissue co-expression partners for DUS3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUS3L Gene:

DUS3L

SOURCE GeneReport for Unigene cluster for DUS3L Gene:

Hs.284297
genes like me logo Genes that share expression patterns with DUS3L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUS3L Gene

Orthologs for DUS3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS3L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUS3L 34
  • 85.35 (n)
  • 86.53 (a)
DUS3L 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUS3L 34
  • 86.35 (n)
  • 87.38 (a)
DUS3L 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dus3l 34
  • 81.18 (n)
  • 83.98 (a)
Dus3l 16
Dus3l 35
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUS3L 34
  • 94.44 (n)
  • 93.86 (a)
DUS3L 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dus3l 34
  • 79.17 (n)
  • 82.97 (a)
oppossum
(Monodelphis domestica)
Mammalia DUS3L 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUS3L 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUS3L 34
  • 68.18 (n)
  • 68.93 (a)
DUS3L 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUS3L 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dus3l 34
  • 63.55 (n)
  • 70.49 (a)
MGC76275 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53781 34
zebrafish
(Danio rerio)
Actinopterygii dus3l 34
  • 67.21 (n)
  • 66.89 (a)
zgc63779 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4216 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009171 34
  • 55.96 (n)
  • 48.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10463 34
  • 54.59 (n)
  • 48.32 (a)
CG10463 35
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y37E11B.5 34
  • 53.79 (n)
  • 54.96 (a)
Y37E11B.5 35
  • 50 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER070C 34
  • 56.59 (n)
  • 43.77 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03069g 34
  • 45.05 (n)
  • 38.66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS3 34
  • 47.53 (n)
  • 40.84 (a)
DUS3 35
  • 34 (a)
OneToMany
DUS3 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G38890 34
  • 51.3 (n)
  • 50.29 (a)
rice
(Oryza sativa)
Liliopsida Os.7618 34
Os04g0117600 34
  • 52.97 (n)
  • 53.78 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.25338 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2732 34
bread mold
(Neurospora crassa)
Ascomycetes NCU02619 34
  • 56.03 (n)
  • 45.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dus3 34
  • 45.18 (n)
  • 39.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8801 35
  • 57 (a)
OneToMany
Species where no ortholog for DUS3L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DUS3L Gene

ENSEMBL:
Gene Tree for DUS3L (if available)
TreeFam:
Gene Tree for DUS3L (if available)

Paralogs for DUS3L Gene

Paralogs for DUS3L Gene

genes like me logo Genes that share paralogs with DUS3L: view

Variants for DUS3L Gene

Sequence variations from dbSNP and Humsavar for DUS3L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2436487 - 5,789,554(-) ACCTG(A/G)GGCCC intron-variant, nc-transcript-variant, reference, missense
VAR_027093 -
rs3210615 -- 5,787,073(-) GGCGT(C/G)GCACT nc-transcript-variant, reference, synonymous-codon
rs10682953 -- 5,792,314(+) AAAAA(-/A)GTAAA upstream-variant-2KB
rs4297808 -- 5,792,362(+) taatt(A/T)gttga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DUS3L Gene

Variant ID Type Subtype PubMed ID
esv1024134 CNV insertion 17803354
esv1693395 CNV insertion 17803354
esv3393878 CNV duplication 20981092
esv3399820 CNV insertion 20981092
nsv1062851 CNV gain 25217958
nsv470119 CNV loss 18288195
nsv525707 CNV loss 19592680
nsv817812 CNV loss 17921354

Variation tolerance for DUS3L Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.81; 91.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUS3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUS3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUS3L Gene

Disorders for DUS3L Gene

Relevant External Links for DUS3L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUS3L

No disorders were found for DUS3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUS3L Gene

Publications for DUS3L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for DUS3L Gene

Sources for DUS3L Gene

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