Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUS2L Gene

protein-coding   GIFtS: 51
GCID: GC16P068058

dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)

(Previous names: dihydrouridine synthase 2-like (SMM1, S. cerevisiae) )
 Explore 1 disease affiliated with
DUS2L via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DUS2L    

Aliases
for DUS2L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dihydrouridine Synthase 2-Like, SMM1 Homolog (S. Cerevisiae)1 2     Dihydrouridine Synthase 2-Like (SMM1, S. Cerevisiae)1
DUS21 2 3 5     TRNA-Dihydrouridine(20) Synthase [NAD(P)+]-Like2
SMM11 2     EC 1.3.1.-3
Up-Regulated In Lung Cancer Protein 82 3     HDUS21
URLC82 3     TRNA-Dihydrouridine Synthase 2-Like3
FLJ203991     

External Ids:    HGNC: 260141   Entrez Gene: 549202   Ensembl: ENSG000001672647   OMIM: 6097075   UniProtKB: Q9NX743   

Export aliases for DUS2L gene to outside databases

Previous GC identifers: GC16P066615 GC16P053930


Summaries
for DUS2L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DUS2L:
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the
D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may
increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in
pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. (provided by
RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: DUS2L_HUMAN, Q9NX74
Function: Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of
most tRNAs




Genomic Views
for DUS2L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUS2L gene promoter:
         AML1a   NF-YA   Nkx2-5   NF-YB   POU2F1   CBF-B   CBF-A   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DUS2L promoter sequence
   Search SABiosciences Chromatin IP Primers for DUS2L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUS2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

DUS2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUS2L gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P068058:  view genomic region     (about GC identifiers)

Start:
 68,021,649 bp from pter      End:
 68,113,223 bp from pter
Size:
 91,575 bases      Orientation:
 plus strand

Proteins
for DUS2L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DUS2L_HUMAN, Q9NX74 (See protein sequence)
Recommended Name: tRNA-dihydrouridine(20) synthase [NAD(P)+]-like  
Size: 493 amino acids; 55050 Da
Cofactor: FAD (By similarity)
Subunit: Interacts with EPRS
Subcellular location: Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum
Secondary accessions: A8K3G3 Q4H4D9

Explore the universe of human proteins at neXtProt for DUS2L: NX_Q9NX74

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NX74

    • DUS2L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258691.1  NP_001258692.1  NP_060273.1  

    ENSEMBL proteins: 
     ENSP00000458906   ENSP00000461244   ENSP00000461659   ENSP00000458152   ENSP00000454252  
     ENSP00000455229   ENSP00000351769   ENSP00000455977   ENSP00000454424   ENSP00000409498  
     ENSP00000456261   ENSP00000456677   ENSP00000463498   ENSP00000457292  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: DUS2L
    OriGene Protein Over-expression Lysate: DUS2L
    OriGene Custom Protein Services for DUS2L 
    GenScript Custom Purified and Recombinant Proteins Services for DUS2L
    Novus Biologicals DUS2L Protein
    Novus Biologicals DUS2L Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DUS2L

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--


    DUS2L for ontologies           About GeneDecksing



    DUS2L Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DUS2L 
    GenScript Custom Superior Antibodies Services for DUS2L
    Novus Biologicals DUS2L Antibodies
    Search for Antibodies for DUS2L at Abcam  
    Uscn Antibodies for DUS2L
    Search ThermoFisher Antibodies for DUS2L

    Assay Products for DUS2L: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DUS2L
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DUS2L

    Protein Domains /
    Families
    for DUS2L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DUS2L for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013785 Aldolase_TIM
     IPR001159 Ds-RNA-bd
     IPR001269 tRNA_hU_synthase
     IPR018517 tRNA_hU_synthase_CS
     IPR014720 dsRNA-bd-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NX74

    ProtoNet protein and cluster: Q9NX74

    1 Blocks protein family: IPB001269 Protein of unknown function UPF0034

    UniProtKB/Swiss-Prot: DUS2L_HUMAN, Q9NX74
    Similarity: Belongs to the dus family. Dus2 subfamily
    Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain


    Function
    for DUS2L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DUS2L_HUMAN, Q9NX74
    Function: Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of
    most tRNAs

    Enzyme Number (IUBMB): EC 1.3.1.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DUS2L
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUS2L
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DUS2L (see all 9):
    hsa-miR-137 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-511 hsa-miR-3622b-3p hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmid: DUS2L 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUS2L (see all 7)
    OriGene shRNA RFP: DUS2L
    OriGene siRNA: DUS2L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUS2L

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DUS2L

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUS2L (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUS2L (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DUS2L (NM_017803)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUS2L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUS2L 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DUS2L
    Search LifeMap BioReagents cell lines for DUS2L

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUS2L

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IEA--
    GO:0017150tRNA dihydrouridine synthase activity IEA--
    GO:0050660flavin adenine dinucleotide binding IEA--


    DUS2L for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DUS2L:
     Synthetic lethal with c-Myc af 


    Pathways & Interactions
    for DUS2L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUS2L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/33 Interacting proteins for DUS2L (Q9NX742, 3 ENSP000003517694) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271069 I2D: score=2 
    SMN2Q166372, 3MINT-8271069 I2D: score=2 
    TK1P041832, 3MINT-8273301 I2D: score=2 
    EIF2S1P051983, ENSP000002563834I2D: score=1 STRING: ENSP00000256383
    METTL1Q9UBP63, ENSP000003144414I2D: score=1 STRING: ENSP00000314441
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008033tRNA processing ----


    DUS2L for ontologies           About GeneDecksing



    Drugs & Compounds
    for DUS2L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUS2L

    2 HMDB Compounds for DUS2L    About this table
    CompoundSynonyms CAS #PubMed Ids
    5,6-Dihydrouridine5,6-Dihydrouridine (see all 4)5627-05-4--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Search CenterWatch for drugs/clinical trials and news about DUS2L 

    Transcripts
    for DUS2L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DUS2L gene (3 alternative transcripts): 
    NM_001271762.1  NM_001271763.1  NM_017803.4  

    Unigene Cluster for DUS2L:

    Dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
    Hs.534460  [show with all ESTs]
    Unigene Representative Sequence: NM_017803
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000571081 ENST00000570709 ENST00000575677 ENST00000576994 ENST00000566306
    ENST00000565263(uc002evi.3) ENST00000358896(uc002evj.3) ENST00000564975
    ENST00000568099 ENST00000567100 ENST00000432752(uc010vkk.2) ENST00000569289
    ENST00000564781 ENST00000562246 ENST00000561965 ENST00000565980

    miRNA
    Products:             		 OriGene 3'-UTR Clone: DUS2L
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUS2L
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DUS2L (see all 9):
    hsa-miR-137 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-511 hsa-miR-3622b-3p hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmid: DUS2L 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUS2L (see all 7)
    OriGene shRNA RFP: DUS2L
    OriGene siRNA: DUS2L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUS2L
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUS2L (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUS2L (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DUS2L (NM_017803)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUS2L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUS2L 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUS2L
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUS2L
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUS2L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUS2L

    Additional cDNA sequence: 

    AB101210.1 AK000406.1 AK290578.1 AK296663.1 BC006527.2 

    12 DOTS entries:

    DT.92443416  DT.101958141  DT.97846387  DT.100781561  DT.100699167  DT.100781566  DT.120665024  DT.120665168 
    DT.120665186  DT.95195381  DT.111847  DT.444077 

    24/164 AceView cDNA sequences (see all 164):

    CD674304 CR611004 AI829086 BX280459 BQ923495 BM927371 AU280519 BQ057742 
    AA470745 AI498808 AI634323 BM142096 AA992987 AW628942 BQ934619 AI360732 
    NM_017803 BQ058977 CR593912 AA928557 CR613036 BM797500 CA396152 CB054195 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DUS2L    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
    SP1:                                            -                                                                 -                           
    SP2:                    -                       -                                                                 -                           
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          


    ECgene alternative splicing isoforms for DUS2L

    Expression
    for DUS2L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUS2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCAGGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DUS2L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUS2L

    SOURCE GeneReport for Unigene cluster: Hs.534460

    UniProtKB/Swiss-Prot: DUS2L_HUMAN, Q9NX74
    Tissue specificity: Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at
    protein level)

        SABiosciences Custom PCR Arrays for DUS2L
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUS2L
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUS2L
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUS2L
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUS2L
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUS2L

    Orthologs
    for DUS2L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for DUS2L gene from 10/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DUS2L1 dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) less 67.7(n)
    71.84(a)    		   415712  XM_414079.3  XP_414079.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DUS2L6
    		 --
    		 71(a)
    		 1 ↔ 1
    		 LGc(6243392-6261422)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.36732 Transcribed sequence with weak similarity to protein refNP_060273.1 (H.sapiens) hypothetical protein FLJ20399 [Homo sapiens] less 72.45(n)    AL870454.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.264152 Transcribed sequence with weak similarity to protein refNP_060273.1 (H.sapiens) hypothetical protein FLJ20399 [Homo sapiens] less 74.09(n)    CA472905.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG14341 CG1434 54.64(n)
    50.91(a)    		   32377  NM_132722.2  NP_572950.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y54E5A.61 Protein Y54E5A.6 50.52(n)
    42.96(a)    		   173331  NM_061153.1  NP_493554.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SMM1(YNR015W)4
    SMM11    		 Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs less4
    Smm1p1    		 49.04(n)1
    42.09(a)1    		   14(653387-654541)4
    8557491, 4  NP_014412.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G496401 tRNA-dihydrouridine synthase 2 54.4(n)
    50.49(a)    		   824126  NM_114824.4  NP_190533.3 
    rice
    (Oryza sativa)    		 Liliopsida Os04g05313001 hypothetical protein 54.64(n)
    52.32(a)    		   4336488  NM_001059930.1  NP_001053395.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria dusC6
    dusA6
    		 tRNA-dihydrouridine synthase A
    		 20(a)
    16(a)
    		 possible ortholog
    possible ortholog
    		 Chromosome(2227460-2228407)
    Chromosome(4259737-4260729)


    ENSEMBL Gene Tree for DUS2L (if available)
    TreeFam Gene Tree for DUS2L (if available) 

    Paralogs
    for DUS2L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DUS2L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/779 NCBI SNPs in DUS2L are shown (see all 779)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1441107321,2
    		--68055247(+) TGACAC/TGATAC 2 -- us2k1 ut310--------
    rs20745751,2
    		C,F,H,--68055378(-) TGTCGG/ACTCCT 2 -- ut31 us2k18Minor allele frequency- A:0.18EA NS NA 2032
    rs1908842681,2
    		--68055380(+) GAGCCA/GACAGG 2 -- ut31 us2k10--------
    rs1486677641,2
    		C,--68055444(+) AAGATC/TCCTGT 2 -- ut31 us2k10--------
    rs1809957351,2
    		C,--68055448(+) TCCCTA/GTTCTA 2 -- us2k1 ut310--------
    rs769023721,2
    		C,F,--68057158(+) GCCGCG/CACCTC 2 -- us2k1 ut511Minor allele frequency- C:0.14WA 118
    rs1509337261,2
    		--68057169(+) GCGTAA/CGGTGG 2 -- ut51 us2k10--------
    rs1406572631,2
    		--68057232(+) AGGTTA/CTTTTT 2 -- ut510--------
    rs735964001,2
    		C,F,--68057442(+) GTTCCC/TCATTG 2 -- ut51 int12Minor allele frequency- T:0.50WA 4
    rs1830943751,2
    		--68057552(+) TGAATA/GAATGA 2 -- int1 ut510--------

    HapMap Linkage Disequilibrium report for DUS2L (68021649 - 68113223 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DUS2L: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUS2L
    DNA2.0 Custom Variant and Variant Library Synthesis for DUS2L

    Disorders / Diseases
    for DUS2L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DUS2L for disorders           About GeneDecksing

    OMIM gene information: 609707    OMIM disorders: --

    1 disease for DUS2L:    About MalaCards
    lung cancer

    1 disease from the University of Copenhagen DISEASES database for DUS2L:
    Lung cancer
    Human Genome Epidemiology (HuGE) Navigator: DUS2L (1 document)

    Export disorders for DUS2L gene to outside databases

    Publications
    for DUS2L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUS2L gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with DUS2L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. (PubMed id 15994936)1, 2, 9 Kato T.... Nakamura Y. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR. (PubMed id 18096616)1, 9 Mittelstadt M....Patel R.C. (2008)
    6. Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of human dihydrouridine synthase. (PubMed id 22442237)1 Griffiths S....Whelan F. (2012)
    7. Molecular evolution of dihydrouridine synthases. (PubMed id 22741570)1 Kasprzak J.M....Bujnicki J.M. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    External Searches for DUS2L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DUS2L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54920 HGNC: 26014 AceView: FLJ20399 Ensembl:ENSG00000167264 euGenes: HUgn54920
    ECgene: DUS2L H-InvDB: DUS2L

    Other Databases showing DUS2L gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DUS2L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUS2L Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DUS2L gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DUS2L gene:
    Search GeneIP for patents involving DUS2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DUS2L gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for DUS2L  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUS2L   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUS2L  
     OriGene Protein Over-expression Lysate for DUS2L   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for DUS2L   OriGene 3'-UTR Clone for DUS2L  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUS2L   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUS2L  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for DUS2L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DUS2L   OriGene Custom Protein Services for DUS2L  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUS2L
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUS2L
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUS2L
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUS2L
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUS2L
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUS2L
     GenScript Custom Purified and Recombinant Proteins Services for DUS2L GenScript cDNA clones with any tag delivered in your preferred vector for DUS2L
     GenScript Custom Assay Services for DUS2L GenScript Custom Superior Antibodies Services for DUS2L
     GenScript Custom overexpressing Cell Line Services for DUS2L CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DUS2L promoter
     Search Chromatin IP Primers for DUS2L
     RT2 qPCR Primer Assay in human, mouse, rat DUS2L
     Search GNC Networks for DUS2L
     SABiosciences Custom PCR Arrays for DUS2L
     Search Tocris compounds for DUS2L
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DUS2L antibodies
     DUS2L proteins
     DUS2L lysates
     Search for Antibodies for DUS2L at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DUS2L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     DUS2L Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for DUS2L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUS2L
     SwitchGear 3'UTR luciferase reporter plasmids for DUS2L
     SwitchGear Promoter luciferase reporter plasmids for DUS2L
     Search ThermoFisher Antibodies for DUS2L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUS2L
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      DUS2L gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4