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Aliases for DUS2 Gene

Aliases for DUS2 Gene

  • Dihydrouridine Synthase 2 2 3 4
  • Up-Regulated In Lung Cancer Protein 8 3 4
  • DUS2L 3 4
  • URLC8 3 4
  • Dihydrouridine Synthase 2-Like, SMM1 Homolog (S. Cerevisiae) 2
  • Dihydrouridine Synthase 2-Like (SMM1, S. Cerevisiae) 2
  • TRNA-Dihydrouridine(20) Synthase [NAD(P)+]-Like 3
  • Dihydrouridine Synthase 2-Like, SMM1 Homolog 3
  • TRNA-Dihydrouridine Synthase 2-Like 4
  • Dihydrouridine Synthase 2-Like 2
  • SMM1 Homolog (S. Cerevisiae) 2
  • SMM1 Homolog 3
  • EC 1.3.1.- 4
  • DUS2L, 6
  • HDUS2 4
  • SMM1 3

External Ids for DUS2 Gene

Previous Symbols for DUS2 Gene

  • DUS2L

Summaries for DUS2 Gene

Entrez Gene Summary for DUS2 Gene

  • This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for DUS2 Gene

DUS2 (Dihydrouridine Synthase 2) is a Protein Coding gene. Diseases associated with DUS2 include lung cancer. GO annotations related to this gene include flavin adenine dinucleotide binding and protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for DUS2 Gene

  • Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS2 Gene

Genomics for DUS2 Gene

Genomic Location for DUS2 Gene

Start:
67,987,746 bp from pter
End:
68,079,323 bp from pter
Size:
91,578 bases
Orientation:
Plus strand

Genomic View for DUS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS2 Gene

No data available for Regulatory Elements for DUS2 Gene

Proteins for DUS2 Gene

  • Protein details for DUS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX74-DUS2L_HUMAN
    Recommended name:
    tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
    Protein Accession:
    Q9NX74
    Secondary Accessions:
    • A8K3G3
    • Q4H4D9

    Protein attributes for DUS2 Gene

    Size:
    493 amino acids
    Molecular mass:
    55050 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with EPRS. Interacts (via DRBM domain) with PRKRA and EIF2AK2/PKR (via DRBM 1 domain).

    Three dimensional structures from OCA and Proteopedia for DUS2 Gene

neXtProt entry for DUS2 Gene

Proteomics data for DUS2 Gene at MOPED

Post-translational modifications for DUS2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys170

No data available for DME Specific Peptides for DUS2 Gene

Domains for DUS2 Gene

UniProtKB/Swiss-Prot:

DUS2L_HUMAN
Domain:
  • Contains 1 DRBM (double-stranded RNA-binding) domain.:
    • Q9NX74
Family:
  • Belongs to the Dus family. Dus2 subfamily.:
    • Q9NX74
genes like me logo Genes that share domains with DUS2: view

No data available for Gene Families for DUS2 Gene

Function for DUS2 Gene

Molecular function for DUS2 Gene

UniProtKB/Swiss-Prot Function: Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.

Enzyme Numbers (IUBMB) for DUS2 Gene

Gene Ontology (GO) - Molecular Function for DUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 18096616
GO:0004860 protein kinase inhibitor activity IDA 18096616
GO:0005515 protein binding IPI 18096616
GO:0017150 tRNA dihydrouridine synthase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with DUS2: view

Phenotypes for DUS2 Gene

GenomeRNAi human phenotypes for DUS2:
genes like me logo Genes that share phenotypes with DUS2: view

miRNA for DUS2 Gene

miRTarBase miRNAs that target DUS2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUS2 Gene

Localization for DUS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUS2 Gene

Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for DUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with DUS2: view

Pathways for DUS2 Gene

SuperPathways for DUS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0006469 negative regulation of protein kinase activity IDA 18096616
GO:0008033 tRNA processing --
GO:0055114 oxidation-reduction process IEA --
GO:0060548 negative regulation of cell death IDA 18096616
genes like me logo Genes that share ontologies with DUS2: view

No data available for Pathways by source for DUS2 Gene

Transcripts for DUS2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for DUS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for DUS2 Gene

GeneLoc Exon Structure for
DUS2
ECgene alternative splicing isoforms for
DUS2

Expression for DUS2 Gene

mRNA expression in normal human tissues for DUS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUS2 Gene

This gene is overexpressed in Whole Blood (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUS2 Gene

mRNA Expression by UniProt/SwissProt for DUS2 Gene

Q9NX74-DUS2L_HUMAN
Tissue specificity: Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).
genes like me logo Genes that share expressions with DUS2: view

Orthologs for DUS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUS2L 36
  • 99.59 (n)
  • 99.39 (a)
DUS2L 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUS2L 36
  • 89.93 (n)
  • 91.68 (a)
DUS2L 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUS2 36
  • 89.86 (n)
  • 91.08 (a)
DUS2 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dus2 36
  • 88.28 (n)
  • 90.45 (a)
Dus2l 16
Dus2l 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUS2 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUS2 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dus2 36
  • 87.87 (n)
  • 89.23 (a)
chicken
(Gallus gallus)
Aves DUS2 37
  • 67 (a)
OneToOne
DUS2L 36
  • 68.03 (n)
  • 71.57 (a)
lizard
(Anolis carolinensis)
Reptilia DUS2 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dus2 36
  • 65.94 (n)
  • 65.28 (a)
Str.3673 36
zebrafish
(Danio rerio)
Actinopterygii Dr.26415 36
dus2 36
  • 66.74 (n)
  • 67.26 (a)
dus2 37
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000856 36
  • 54.56 (n)
  • 48.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1434 36
  • 54.34 (n)
  • 50.46 (a)
CG1434 37
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y54E5A.6 36
  • 50.52 (n)
  • 42.96 (a)
Y54E5A.6 37
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMM1 37
  • 34 (a)
OneToOne
SMM1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49640 36
  • 54.29 (n)
  • 50.49 (a)
rice
(Oryza sativa)
Liliopsida Os04g0531300 36
  • 54.64 (n)
  • 52.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3263 37
  • 53 (a)
OneToOne
Species with no ortholog for DUS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUS2 Gene

ENSEMBL:
Gene Tree for DUS2 (if available)
TreeFam:
Gene Tree for DUS2 (if available)

Paralogs for DUS2 Gene

No data available for Paralogs for DUS2 Gene

Variants for DUS2 Gene

Sequence variations from dbSNP and Humsavar for DUS2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs171113 -- 68,047,204(-) gtggc(A/G)cgtgc intron-variant
rs237832 -- 68,064,642(-) AAGGG(C/G)GGGAC intron-variant
rs1127629 -- 68,079,180(+) TGGAT(C/T)TGAGT utr-variant-3-prime
rs1985437 -- 68,040,954(+) Cgccg(A/G)gcgtg intron-variant
rs2158368 -- 68,051,698(-) aaaca(A/G)aaaca intron-variant

Relevant External Links for DUS2 Gene

HapMap Linkage Disequilibrium report
DUS2

No data available for Structural Variations from Database of Genomic Variants (DGV) for DUS2 Gene

Disorders for DUS2 Gene

(1) MalaCards Diseases for DUS2 Gene

Search for DUS2 Gene in MalaCards »
genes like me logo Genes that share disorders with DUS2: view

No data available for UniProtKB/Swiss-Prot for DUS2 Gene

Publications for DUS2 Gene

  1. A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. (PMID: 15994936) Kato T. … Nakamura Y. (Cancer Res. 2005) 2 3 4 23
  2. Interaction of human tRNA-dihydrouridine synthase-2 with interferon- induced protein kinase PKR. (PMID: 18096616) Mittelstadt M. … Patel R.C. (Nucleic Acids Res. 2008) 3 4 23
  3. Molecular evolution of dihydrouridine synthases. (PMID: 22741570) Kasprzak J.M. … Bujnicki J.M. (BMC Bioinformatics 2012) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DUS2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DUS2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DUS2
    • Block miRNA regulation of DUS2 using miScript Target Protectors

    Sources for DUS2 Gene

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