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DUS2 Gene

protein-coding   GIFtS: 43
GCID: GC16P068021

Dihydrouridine Synthase 2

(Previous names: dihydrouridine synthase 2-like (SMM1, S. cerevisiae), dihydrouridine...)
(Previous symbol: DUS2L)
  See DUS2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dihydrouridine Synthase 21 2 3     SMM12
DUS2L1 2 3 5     Dihydrouridine Synthase 2-Like, SMM1 Homolog2
Up-Regulated In Lung Cancer Protein 82 3     SMM1 Homolog2
URLC82 3     TRNA-Dihydrouridine(20) Synthase [NAD(P)+]-Like2
Dihydrouridine Synthase 2-Like1     EC 1.3.1.-3
Dihydrouridine Synthase 2-Like (SMM1, S. Cerevisiae)1     hDUS23
Dihydrouridine Synthase 2-Like, SMM1 Homolog (S. Cerevisiae)1     TRNA-Dihydrouridine Synthase 2-Like3
SMM1 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 260141   Entrez Gene: 549202   Ensembl: ENSG000001672647   OMIM: 6097075   UniProtKB: Q9NX743   

Export aliases for DUS2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUS2 Gene:
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the
D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein
may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been
implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this
gene. (provided by RefSeq, Nov 2012)

GeneCards Summary for DUS2 Gene:
DUS2 (dihydrouridine synthase 2) is a protein-coding gene. Diseases associated with DUS2 include lung cancer. GO annotations related to this gene include protein kinase inhibitor activity and flavin adenine dinucleotide binding.

UniProtKB/Swiss-Prot: DUS2L_HUMAN, Q9NX74
Function: Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop
of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for DUS2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUS2 promoter sequence
   Search Chromatin IP Primers for DUS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

DUS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUS2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P068021:  view genomic region     (about GC identifiers)

Start:
68,021,649 bp from pter      End:
68,113,223 bp from pter
Size:
91,575 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DUS2L_HUMAN, Q9NX74 (See protein sequence)
Recommended Name: tRNA-dihydrouridine(20) synthase [NAD(P)+]-like  
Size: 493 amino acids; 55050 Da
Cofactor: FAD (By similarity)
Subunit: Interacts with EPRS. Interacts (via DRBM domain) with PRKRA and EIF2AK2/PKR (via DRBM 1 domain)
Secondary accessions: A8K3G3 Q4H4D9

Explore the universe of human proteins at neXtProt for DUS2: NX_Q9NX74

Explore proteomics data for DUS2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys170
  • Modification sites at PhosphoSitePlus

  • See DUS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258691.1  NP_001258692.1  NP_060273.1  

    ENSEMBL proteins: 
     ENSP00000458906   ENSP00000461244   ENSP00000461659   ENSP00000458152   ENSP00000454252  
     ENSP00000455229   ENSP00000351769   ENSP00000455977   ENSP00000454424   ENSP00000409498  
     ENSP00000456261   ENSP00000456677   ENSP00000463498   ENSP00000457292  

    DUS2 Human Recombinant Protein Products:

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    Novus Biologicals DUS2 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DUS2 

     
    antibodies-online proteins for DUS2 (4 products) 

     
    antibodies-online peptides for DUS2

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    antibodies-online antibodies for DUS2 (21 products) 

    DUS2 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for DUS2 
    antibodies-online kits for DUS2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR001269 tRNA_hU_synthase
     IPR018517 tRNA_hU_synthase_CS
     IPR014720 dsRNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9NX74

    ProtoNet protein and cluster: Q9NX74

    1 Blocks protein domain: IPB001269 Protein of unknown function UPF0034

    UniProtKB/Swiss-Prot: DUS2L_HUMAN, Q9NX74
    Similarity: Belongs to the Dus family. Dus2 subfamily
    Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain


    Find genes that share domains with DUS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS2L_HUMAN, Q9NX74
    Function: Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop
    of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR

         Enzyme Number (IUBMB): EC 1.3.1.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IDA18096616
    GO:0004860protein kinase inhibitor activity IDA18096616
    GO:0005515protein binding IPI18096616
    GO:0017150tRNA dihydrouridine synthase activity IEA--
    GO:0050660flavin adenine dinucleotide binding IEA--
         
    Find genes that share ontologies with DUS2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DUS2:
     Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DUS2

    miRNA
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    miRTarBase miRNAs that target DUS2:
    hsa-mir-324-3p (MIRT042984)

    Block miRNA regulation of human, mouse, rat DUS2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DUS2
    SwitchGear 3'UTR luciferase reporter plasmidDUS2 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat DUS2

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUS2

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS2L_HUMAN, Q9NX74: Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--

    Find genes that share ontologies with DUS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DUS2
    Interactions:

        Search GeneGlobe Interaction Network for DUS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DUS2 (Q9NX742, 3 ENSP000003517694) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271069 I2D: score=2 
    SMN2Q166372, 3MINT-8271069 I2D: score=2 
    TK1P041832, 3MINT-8273301 I2D: score=2 
    ENSG00000206288Q925043I2D: score=1 
    ENSG00000224399Q925043I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity IDA18096616
    GO:0008033tRNA processing ----
    GO:0055114oxidation-reduction process ----
    GO:0060548negative regulation of cell death IDA18096616

    Find genes that share ontologies with DUS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUS2 (DUS2L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DUS2 gene (3 alternative transcripts): 
    NM_001271762.1  NM_001271763.1  NM_017803.4  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000571081 ENST00000570709 ENST00000575677 ENST00000576994 ENST00000566306
    ENST00000565263(uc002evi.3) ENST00000358896(uc002evj.3) ENST00000564975
    ENST00000568099 ENST00000567100 ENST00000432752(uc010vkk.2) ENST00000569289
    ENST00000564781 ENST00000562246 ENST00000561965 ENST00000565980
    miRNA
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    Block miRNA regulation of human, mouse, rat DUS2 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidDUS2 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat DUS2
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    GenScript Custom all cDNA clones Services for DUS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUS2
    Primer
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    OriGene qPCR primer pairs and template standards for DUS2
    OriGene qSTAR qPCR primer pairs in human, mouse for DUS2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DUS2
      QuantiTect SYBR Green Assays in human, mouse, rat DUS2
      QuantiFast Probe-based Assays in human, mouse, rat DUS2

    Selected AceView cDNA sequences (see all 164):

    AW450641 BM696393 CR593912 BM927371 AA470745 BM796236 BC006527 CD674304 
    BM797500 CR624298 AI634323 AI360732 AI821002 BX280459 BM699928 C00316 
    BP356446 AL527986 BE675030 AA992987 AA928557 CB054195 BE017982 CR611004 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DUS2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
    SP1:                                            -                                                                 -                           
    SP2:                    -                       -                                                                 -                           
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          


    ECgene alternative splicing isoforms for DUS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DUS2 Expression
    About this image


    DUS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Lymph (Hematopoietic System)
    DUS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUS2 Protein Expression

    UniProtKB/Swiss-Prot: DUS2L_HUMAN, Q9NX74
    Tissue specificity: Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells
    (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUS2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dus2l5
    Dus21
    dihydrouridine synthase 2-like (SMM1, S. cerevisiae)5
    dihydrouridine synthase 21
    88.28(n)1
    90.45(a)1
      8 (53.07 cM)5
    663691  NM_025518.31  NP_079794.11 
     1059913375 
    chicken
    (Gallus gallus)
    Aves DUS2L1 dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) 68.03(n)
    71.57(a)
      415712  XM_004944167.1  XP_004944224.1 
    lizard
    (Anolis carolinensis)
    Reptilia DUS26
    dihydrouridine synthase 2
    71(a)
    1 ↔ 1
    LGc(6243383-6261283)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.36732 Transcribed sequence with weak similarity to protein more 72.45(n)    AL870454.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.264152 Transcribed sequence with weak similarity to protein more 74.09(n)    CA472905.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14341 CG1434 54.34(n)
    50.46(a)
      32377  NM_132722.2  NP_572950.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E5A.61 Y54E5A.6 50.52(n)
    42.96(a)
      173331  NM_061153.1  NP_493554.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMM1(YNR015W)4 Dihydrouridine synthase, member of a family of dihydrouridine more   --   14(653387-654541) 855749  NP_014412.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G496401 AT3G49640 54.29(n)
    50.49(a)
      824126  NM_114824.4  NP_190533.3 
    rice
    (Oryza sativa)
    Liliopsida Os04g05313001 Os04g0531300 54.64(n)
    52.32(a)
      4336488  NM_001059930.1  NP_001053395.1 


    ENSEMBL Gene Tree for DUS2 (if available)
    TreeFam Gene Tree for DUS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUS2 (see all 937)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480884131,2
    --68059946(+) TAGACG/TTCAGT 3 -- int10--------
    rs1158526121,2
    F--68059962(+) CATCTC/TGACTC 3 -- int11Minor allele frequency- T:0.03WA 118
    rs1418207551,2
    --68060080(+) GTAGAA/GATGAG 3 -- int10--------
    rs1506101691,2
    --68060165(+) CTGGGA/GTTACA 3 -- int10--------
    rs1162458821,2
    F--68060193(+) CCAGCC/TGAGAA 3 -- int11Minor allele frequency- T:0.01WA 118
    rs1868899191,2
    --68060300(+) AAAGTG/TCTATT 3 -- int10--------
    rs1396440511,2
    --68060355(+) TGTGCA/GCAGGT 3 -- int10--------
    rs746525271,2
    C,F--68060474(+) TTTCCC/TGAGTG 3 -- int11Minor allele frequency- T:0.12NA 120
    rs576160891,2
    C--68061059(+) AAATGA/CACTTT 3 -- int10--------
    rs80469751,2
    C,A--68061171(+) agtttC/Tgctct 3 -- int13Minor allele frequency- T:0.25WA CSA 4

    HapMap Linkage Disequilibrium report for DUS2 (68021649 - 68113223 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DUS2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DUS2
    DNA2.0 Custom Variant and Variant Library Synthesis for DUS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609707    OMIM disorders: --

    1 disease for DUS2:    
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    lung cancer


    Find genes that share disorders with DUS2           About GenesLikeMe


    Export disorders for DUS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUS2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with DUS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. (PubMed id 15994936)1, 2, 3, 9 Kato T.... Nakamura Y. (Cancer Res. 2005)
    2. Interaction of human tRNA-dihydrouridine synthase-2 with interferon- induced protein kinase PKR. (PubMed id 18096616)1, 2, 9 Mittelstadt M....Patel R.C. (Nucleic Acids Res. 2008)
    3. Molecular evolution of dihydrouridine synthases. (PubMed id 22741570)1, 3 Kasprzak J.M....Bujnicki J.M. (BMC Bioinformatics 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of human dihydrouridine synthase. (PubMed id 22442237)1 Griffiths S....Whelan F. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54920 HGNC: 26014 AceView: FLJ20399 Ensembl:ENSG00000167264 euGenes: HUgn54920
    ECgene: DUS2 H-InvDB: DUS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DUS2 gene:
    Search GeneIP for patents involving DUS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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