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Aliases for DUS2 Gene

Aliases for DUS2 Gene

  • Dihydrouridine Synthase 2 2 3 4 5
  • TRNA-Dihydrouridine(20) Synthase (NAD(P)(+)) 2 3
  • Up-Regulated In Lung Cancer Protein 8 3 4
  • DUS2L 3 4
  • URLC8 3 4
  • Dihydrouridine Synthase 2-Like, SMM1 Homolog (S. Cerevisiae) 2
  • Dihydrouridine Synthase 2-Like (SMM1, S. Cerevisiae) 2
  • Dihydrouridine Synthase 2-Like, SMM1 Homolog 3
  • TRNA-Dihydrouridine Synthase 2-Like 4
  • Dihydrouridine Synthase 2-Like 2
  • SMM1 Homolog (S. Cerevisiae) 2
  • SMM1 Homolog 3
  • EC 1.3.1.- 4
  • HDUS2 4
  • SMM1 3

External Ids for DUS2 Gene

Previous HGNC Symbols for DUS2 Gene

  • DUS2L

Summaries for DUS2 Gene

Entrez Gene Summary for DUS2 Gene

  • This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for DUS2 Gene

DUS2 (Dihydrouridine Synthase 2) is a Protein Coding gene. Diseases associated with DUS2 include lung cancer and kabuki syndrome 1. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include flavin adenine dinucleotide binding and protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for DUS2 Gene

  • Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS2 Gene

Genomics for DUS2 Gene

Genomic Location for DUS2 Gene

Chromosome:
16
Start:
67,987,746 bp from pter
End:
68,079,323 bp from pter
Size:
91,578 bases
Orientation:
Plus strand

Genomic View for DUS2 Gene

Genes around DUS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS2 Gene

No data available for Regulatory Elements for DUS2 Gene

Proteins for DUS2 Gene

  • Protein details for DUS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX74-DUS2L_HUMAN
    Recommended name:
    tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
    Protein Accession:
    Q9NX74
    Secondary Accessions:
    • A8K3G3
    • Q4H4D9

    Protein attributes for DUS2 Gene

    Size:
    493 amino acids
    Molecular mass:
    55050 Da
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    • Interacts with EPRS. Interacts (via DRBM domain) with PRKRA and EIF2AK2/PKR (via DRBM 1 domain).

    Three dimensional structures from OCA and Proteopedia for DUS2 Gene

neXtProt entry for DUS2 Gene

Proteomics data for DUS2 Gene at MOPED

Post-translational modifications for DUS2 Gene

  • Ubiquitination at Lys 170
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DUS2 Gene

Domains & Families for DUS2 Gene

Protein Domains for DUS2 Gene

Suggested Antigen Peptide Sequences for DUS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX74

UniProtKB/Swiss-Prot:

DUS2L_HUMAN :
  • Contains 1 DRBM (double-stranded RNA-binding) domain.
  • Belongs to the Dus family. Dus2 subfamily.
Domain:
  • Contains 1 DRBM (double-stranded RNA-binding) domain.
Family:
  • Belongs to the Dus family. Dus2 subfamily.
genes like me logo Genes that share domains with DUS2: view

No data available for Gene Families for DUS2 Gene

Function for DUS2 Gene

Molecular function for DUS2 Gene

UniProtKB/Swiss-Prot Function:
Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.

Enzyme Numbers (IUBMB) for DUS2 Gene

Gene Ontology (GO) - Molecular Function for DUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017150 tRNA dihydrouridine synthase activity IEA,IBA --
genes like me logo Genes that share ontologies with DUS2: view
genes like me logo Genes that share phenotypes with DUS2: view

Animal Model Products

miRNA for DUS2 Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS2 Gene

Localization for DUS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUS2 Gene

Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DUS2 Gene

Pathways & Interactions for DUS2 Gene

genes like me logo Genes that share pathways with DUS2: view

Pathways by source for DUS2 Gene

Gene Ontology (GO) - Biological Process for DUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS2: view

No data available for SIGNOR curated interactions for DUS2 Gene

Drugs & Compounds for DUS2 Gene

(1) Drugs for DUS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for DUS2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5,6-Dihydrouridine
  • 5,6-Dihydrouridine
  • Dihydro-1-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydro-1-beta-delta-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydrouridine
5627-05-4
genes like me logo Genes that share compounds with DUS2: view

Transcripts for DUS2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for DUS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for DUS2 Gene

GeneLoc Exon Structure for
DUS2
ECgene alternative splicing isoforms for
DUS2

Expression for DUS2 Gene

mRNA expression in normal human tissues for DUS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUS2 Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for DUS2 Gene

This gene is overexpressed in Bone marrow stromal cell (31.5), Testis (6.9), and Heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUS2 Gene



mRNA Expression by UniProt/SwissProt for DUS2 Gene

Q9NX74-DUS2L_HUMAN
Tissue specificity: Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).
genes like me logo Genes that share expression patterns with DUS2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for DUS2 Gene

Orthologs for DUS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUS2L 36
  • 99 (a)
OneToOne
DUS2L 35
  • 99.59 (n)
  • 99.39 (a)
cow
(Bos Taurus)
Mammalia DUS2L 36
  • 92 (a)
OneToOne
DUS2L 35
  • 89.93 (n)
  • 91.68 (a)
dog
(Canis familiaris)
Mammalia DUS2 35
  • 89.86 (n)
  • 91.08 (a)
DUS2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dus2 16
Dus2l 36
  • 90 (a)
OneToOne
Dus2 35
  • 88.28 (n)
  • 90.45 (a)
oppossum
(Monodelphis domestica)
Mammalia DUS2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUS2 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dus2 35
  • 87.87 (n)
  • 89.23 (a)
chicken
(Gallus gallus)
Aves DUS2 36
  • 67 (a)
OneToOne
DUS2L 35
  • 68.03 (n)
  • 71.57 (a)
lizard
(Anolis carolinensis)
Reptilia DUS2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dus2 35
  • 65.94 (n)
  • 65.28 (a)
Str.3673 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26415 35
dus2 35
  • 66.74 (n)
  • 67.26 (a)
dus2 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000856 35
  • 54.56 (n)
  • 48.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1434 36
  • 46 (a)
OneToOne
CG1434 35
  • 54.34 (n)
  • 50.46 (a)
worm
(Caenorhabditis elegans)
Secernentea Y54E5A.6 36
  • 41 (a)
OneToOne
Y54E5A.6 35
  • 50.52 (n)
  • 42.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMM1 36
  • 34 (a)
OneToOne
SMM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49640 35
  • 54.29 (n)
  • 50.49 (a)
rice
(Oryza sativa)
Liliopsida Os04g0531300 35
  • 54.64 (n)
  • 52.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3263 36
  • 53 (a)
OneToOne
Species with no ortholog for DUS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUS2 Gene

ENSEMBL:
Gene Tree for DUS2 (if available)
TreeFam:
Gene Tree for DUS2 (if available)

Paralogs for DUS2 Gene

No data available for Paralogs for DUS2 Gene

Variants for DUS2 Gene

Sequence variations from dbSNP and Humsavar for DUS2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3785106 -- 68,072,602(+) CCAGC(A/C)GGGGC intron-variant
rs3785107 -- 68,072,942(+) TTTTA(C/T)CCACG intron-variant
rs7193014 -- 68,028,218(+) ATGAT(A/G)GCAGT intron-variant
rs7193659 -- 68,028,016(+) CCTTA(C/T)ATTTA intron-variant
rs7186991 -- 68,034,128(+) tggta(C/T)gatat intron-variant

Variation tolerance for DUS2 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 55.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUS2 Gene

HapMap Linkage Disequilibrium report
DUS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DUS2 Gene

Disorders for DUS2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DUS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
kabuki syndrome 1
  • kabuki syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DUS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUS2
genes like me logo Genes that share disorders with DUS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUS2 Gene

Publications for DUS2 Gene

  1. A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. (PMID: 15994936) Kato T. … Nakamura Y. (Cancer Res. 2005) 2 3 4 23 67
  2. Molecular evolution of dihydrouridine synthases. (PMID: 22741570) Kasprzak J.M. … Bujnicki J.M. (BMC Bioinformatics 2012) 2 3
  3. Interaction of human tRNA-dihydrouridine synthase-2 with interferon- induced protein kinase PKR. (PMID: 18096616) Mittelstadt M. … Patel R.C. (Nucleic Acids Res. 2008) 3 23
  4. Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of human dihydrouridine synthase. (PMID: 22442237) Griffiths S. … Whelan F. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for DUS2 Gene

Sources for DUS2 Gene

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