Aliases for DUS2 Gene
- Dihydrouridine Synthase 2 2 3 4 5
- TRNA-Dihydrouridine(20) Synthase (NAD(P)(+)) 2 3
- Up-Regulated In Lung Cancer Protein 8 3 4
- DUS2L 3 4
- URLC8 3 4
- Dihydrouridine Synthase 2-Like, SMM1 Homolog (S. Cerevisiae) 2
- Dihydrouridine Synthase 2-Like (SMM1, S. Cerevisiae) 2
- Dihydrouridine Synthase 2-Like, SMM1 Homolog 3
External Ids for DUS2 Gene
Previous HGNC Symbols for DUS2 Gene
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
GeneCards Summary for DUS2 Gene
DUS2 (Dihydrouridine Synthase 2) is a Protein Coding gene. Diseases associated with DUS2 include lung cancer and kabuki syndrome 1. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include flavin adenine dinucleotide binding and protein kinase inhibitor activity.
UniProtKB/Swiss-Prot for DUS2 Gene
Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.