Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DUS1L Gene

Aliases for DUS1L Gene

  • Dihydrouridine Synthase 1-Like (S. Cerevisiae) 2 3
  • TRNA-Dihydrouridine(16/17) Synthase [NAD(P)(+)]-Like 3
  • TRNA-Dihydrouridine Synthase 1-Like 4
  • EC 1.3.1.- 4
  • PP3111 3
  • DUS1 3

External Ids for DUS1L Gene

Previous GeneCards Identifiers for DUS1L Gene

  • GC17M077610
  • GC17M080015
  • GC17M075415

Summaries for DUS1L Gene

GeneCards Summary for DUS1L Gene

DUS1L (Dihydrouridine Synthase 1-Like (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include flavin adenine dinucleotide binding and tRNA dihydrouridine synthase activity.

UniProtKB/Swiss-Prot for DUS1L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS1L Gene

Genomics for DUS1L Gene

Regulatory Elements for DUS1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUS1L Gene

82,057,506 bp from pter
82,065,887 bp from pter
8,382 bases
Minus strand

Genomic View for DUS1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS1L Gene

Proteins for DUS1L Gene

  • Protein details for DUS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
    Protein Accession:
    Secondary Accessions:
    • A6NHV4
    • Q96AI3

    Protein attributes for DUS1L Gene

    473 amino acids
    Molecular mass:
    53230 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for DUS1L Gene

Proteomics data for DUS1L Gene at MOPED

Post-translational modifications for DUS1L Gene

  • Ubiquitination at Lys199
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DUS1L Gene

Domains for DUS1L Gene

Protein Domains for DUS1L Gene

Suggested Antigen Peptide Sequences for DUS1L Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6P1R4
  • Belongs to the Dus family. Dus1 subfamily.
genes like me logo Genes that share domains with DUS1L: view

No data available for Gene Families for DUS1L Gene

Function for DUS1L Gene

Molecular function for DUS1L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS1L Gene

Gene Ontology (GO) - Molecular Function for DUS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017150 tRNA dihydrouridine synthase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with DUS1L: view

Animal Model Products

miRNA for DUS1L Gene

miRTarBase miRNAs that target DUS1L

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DUS1L Gene

Localization for DUS1L Gene

Subcellular locations from

Jensen Localization Image for DUS1L Gene COMPARTMENTS Subcellular localization image for DUS1L gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS1L Gene

Pathways for DUS1L Gene

SuperPathways for DUS1L Gene

No Data Available

Interacting Proteins for DUS1L Gene

Gene Ontology (GO) - Biological Process for DUS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS1L: view

No data available for Pathways by source for DUS1L Gene

Compounds for DUS1L Gene

(2) HMDB Compounds for DUS1L Gene

Compound Synonyms Cas Number PubMed IDs
  • 5,6-Dihydrouridine
  • 1H-Purin-6-amine flavin dinucleotide
genes like me logo Genes that share compounds with DUS1L: view

Transcripts for DUS1L Gene

Unigene Clusters for DUS1L Gene

Dihydrouridine synthase 1-like (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUS1L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUS1L Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a ·
SP1: -
SP2: - -
SP3: - -
SP5: - -
SP6: - -
SP8: - -

ExUns: 14b · 14c

Relevant External Links for DUS1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUS1L Gene

mRNA expression in normal human tissues for DUS1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DUS1L Gene

This gene is overexpressed in Lung (37.2), Peripheral blood mononuclear cells (12.2), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUS1L Gene

SOURCE GeneReport for Unigene cluster for DUS1L Gene Hs.514599

genes like me logo Genes that share expressions with DUS1L: view

Expression partners for DUS1L Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUS1L Gene

Orthologs for DUS1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUS1L 35
  • 88.75 (n)
  • 93.33 (a)
DUS1L 36
  • 90 (a)
(Canis familiaris)
Mammalia DUS1L 35
  • 90.35 (n)
  • 93.45 (a)
DUS1L 36
  • 93 (a)
(Mus musculus)
Mammalia Dus1l 35
  • 85.34 (n)
  • 91.33 (a)
Dus1l 16
Dus1l 36
  • 91 (a)
(Pan troglodytes)
Mammalia DUS1L 35
  • 99.22 (n)
  • 99.79 (a)
DUS1L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pp3111 35
  • 84.87 (n)
  • 90.09 (a)
(Monodelphis domestica)
Mammalia DUS1L 36
  • 83 (a)
(Gallus gallus)
Aves DUS1L 35
  • 77.11 (n)
  • 82.94 (a)
(Anolis carolinensis)
Reptilia DUS1L 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dus1l 35
  • 74.83 (n)
  • 82.02 (a)
Str.1993 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24034 35
(Danio rerio)
Actinopterygii -- 35
dus1l 35
  • 72.71 (n)
  • 76.83 (a)
dus1l 36
  • 67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008484 35
  • 60.03 (n)
  • 52.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3645 35
  • 60.14 (n)
  • 54.21 (a)
CG3645 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea F36A2.2 35
  • 45.88 (n)
  • 43.29 (a)
F36A2.2 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS1 36
  • 38 (a)
DUS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G67220 35
  • 53.22 (n)
  • 47.59 (a)
(Oryza sativa)
Liliopsida Os06g0712900 35
  • 53.64 (n)
  • 49.46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8130 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6459 36
  • 53 (a)
Species with no ortholog for DUS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUS1L Gene

Gene Tree for DUS1L (if available)
Gene Tree for DUS1L (if available)

Paralogs for DUS1L Gene

Selected SIMAP similar genes for DUS1L Gene using alignment to 10 proteins: Pseudogenes for DUS1L Gene

genes like me logo Genes that share paralogs with DUS1L: view

No data available for Paralogs for DUS1L Gene

Variants for DUS1L Gene

Sequence variations from dbSNP and Humsavar for DUS1L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4280314 -- 82,058,576(+) ACCCC(A/C)ACCCA intron-variant, reference, missense
rs4531805 -- 82,063,098(+) GGCAG(C/T)CCGGG intron-variant
rs4606789 -- 82,066,115(+) GTTCG(A/C)ATTGG upstream-variant-2KB
rs8068632 -- 82,064,391(+) AAAGC(C/T)GGGAG intron-variant
rs8068796 -- 82,064,485(+) ATCTC(C/T)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUS1L Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv909166 CNV Loss 21882294
nsv457975 CNV Loss 19166990
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
dgv3347n71 CNV Loss 21882294
nsv909181 CNV Loss 21882294
dgv3349n71 CNV Loss 21882294
nsv457976 CNV Gain 19166990
nsv470621 CNV Gain 18288195
nsv909186 CNV Loss 21882294
dgv3350n71 CNV Loss 21882294
nsv909188 CNV Loss 21882294
dgv3351n71 CNV Loss 21882294
dgv3352n71 CNV Loss 21882294
nsv909192 CNV Gain 21882294
dgv3353n71 CNV Loss 21882294

Relevant External Links for DUS1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUS1L Gene

Disorders for DUS1L Gene

No disorders were found for DUS1L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DUS1L Gene

Publications for DUS1L Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for DUS1L Gene

Sources for DUS1L Gene

Back to Top