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Aliases for DUS1L Gene

Aliases for DUS1L Gene

  • Dihydrouridine Synthase 1 Like 2 3 5
  • TRNA-Dihydrouridine(16/17) Synthase [NAD(P)(+)]-Like 3
  • Dihydrouridine Synthase 1-Like (S. Cerevisiae) 2
  • TRNA-Dihydrouridine Synthase 1-Like 4
  • EC 1.3.1.- 4
  • PP3111 3
  • DUS1 3

External Ids for DUS1L Gene

Previous GeneCards Identifiers for DUS1L Gene

  • GC17M077610
  • GC17M080015
  • GC17M075415

Summaries for DUS1L Gene

GeneCards Summary for DUS1L Gene

DUS1L (Dihydrouridine Synthase 1 Like) is a Protein Coding gene. GO annotations related to this gene include flavin adenine dinucleotide binding and tRNA dihydrouridine synthase activity.

UniProtKB/Swiss-Prot for DUS1L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS1L Gene

Genomics for DUS1L Gene

Regulatory Elements for DUS1L Gene

Enhancers for DUS1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G082064 1.2 ENCODE 11.2 +0.2 212 2.4 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC CEP131 ENSG00000262049 GPS1 ENSG00000265678 ENSG00000263321 ENSG00000262877 DUS1L LOC100130370 TSPAN10 ENSG00000264548
GH17G082095 2.1 FANTOM5 Ensembl ENCODE dbSUPER 6 -35.9 -35923 13.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 CCDC57 ARL16 DCXR TSPAN10 ENSG00000262049 RFNG DUS1L HEXDC GCGR OXLD1
GH17G082492 2.1 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -429.6 -429606 6.0 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 NARF ENSG00000262049 HGS ENSG00000262652 ARL2BPP9 ALYREF NARF-IT1 RFNG ENSG00000265678 OGFOD3
GH17G082200 1.5 FANTOM5 ENCODE dbSUPER 1.4 -135.0 -135028 1.8 HDAC1 HDGF TBP PKNOX1 TBL1XR1 ARNT NFRKB ZBTB40 TCF12 ELK1 CCDC57 HGS NARF-IT1 ACTG1 TEPSIN ENSG00000262049 ARHGDIA ALYREF CD7 HEXDC
GH17G082072 0.4 FANTOM5 5.1 -6.2 -6243 0.1 HLF DUS1L HEXDC GC17P082085
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUS1L on UCSC Golden Path with GeneCards custom track

Promoters for DUS1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099529 287 1201 MLX ARNT CREB3L1 AGO1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 YY1

Genomic Location for DUS1L Gene

Chromosome:
17
Start:
82,057,506 bp from pter
End:
82,065,887 bp from pter
Size:
8,382 bases
Orientation:
Minus strand

Genomic View for DUS1L Gene

Genes around DUS1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUS1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS1L Gene

Proteins for DUS1L Gene

  • Protein details for DUS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1R4-DUS1L_HUMAN
    Recommended name:
    tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
    Protein Accession:
    Q6P1R4
    Secondary Accessions:
    • A6NHV4
    • Q96AI3

    Protein attributes for DUS1L Gene

    Size:
    473 amino acids
    Molecular mass:
    53230 Da
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available

neXtProt entry for DUS1L Gene

Post-translational modifications for DUS1L Gene

  • Ubiquitination at isoforms=199
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DUS1L Gene

Domains & Families for DUS1L Gene

Protein Domains for DUS1L Gene

Suggested Antigen Peptide Sequences for DUS1L Gene

Graphical View of Domain Structure for InterPro Entry

Q6P1R4

UniProtKB/Swiss-Prot:

DUS1L_HUMAN :
  • Belongs to the Dus family. Dus1 subfamily.
Family:
  • Belongs to the Dus family. Dus1 subfamily.
genes like me logo Genes that share domains with DUS1L: view

No data available for Gene Families for DUS1L Gene

Function for DUS1L Gene

Molecular function for DUS1L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS1L Gene

Gene Ontology (GO) - Molecular Function for DUS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0017150 tRNA dihydrouridine synthase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with DUS1L: view
genes like me logo Genes that share phenotypes with DUS1L: view

Animal Model Products

CRISPR Products

miRNA for DUS1L Gene

miRTarBase miRNAs that target DUS1L

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS1L Gene

Localization for DUS1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUS1L gene
Compartment Confidence
nucleus 3
plasma membrane 2
extracellular 2
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS1L Gene

Pathways & Interactions for DUS1L Gene

SuperPathways for DUS1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS1L: view

No data available for Pathways by source and SIGNOR curated interactions for DUS1L Gene

Drugs & Compounds for DUS1L Gene

(1) Drugs for DUS1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for DUS1L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5,6-Dihydrouridine
  • 5,6-Dihydrouridine
  • Dihydro-1-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydro-1-beta-delta-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Dihydrouridine
5627-05-4
genes like me logo Genes that share compounds with DUS1L: view

Transcripts for DUS1L Gene

Unigene Clusters for DUS1L Gene

Dihydrouridine synthase 1-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUS1L Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a ·
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: - -
SP7:
SP8: - -
SP9:
SP10:
SP11:

ExUns: 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DUS1L Gene

GeneLoc Exon Structure for
DUS1L
ECgene alternative splicing isoforms for
DUS1L

Expression for DUS1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUS1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUS1L Gene

This gene is overexpressed in Lung (37.2), Peripheral blood mononuclear cells (12.2), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUS1L Gene



Protein tissue co-expression partners for DUS1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUS1L Gene:

DUS1L

SOURCE GeneReport for Unigene cluster for DUS1L Gene:

Hs.514599

Evidence on tissue expression from TISSUES for DUS1L Gene

  • Nervous system(4.7)
  • Intestine(4.4)
  • Pancreas(4.3)
  • Lung(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with DUS1L: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUS1L Gene

Orthologs for DUS1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUS1L 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia DUS1L 34 35
  • 90.35 (n)
cow
(Bos Taurus)
Mammalia DUS1L 34 35
  • 88.75 (n)
mouse
(Mus musculus)
Mammalia Dus1l 34 16 35
  • 85.34 (n)
rat
(Rattus norvegicus)
Mammalia Pp3111 34
  • 84.87 (n)
oppossum
(Monodelphis domestica)
Mammalia DUS1L 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUS1L 34
  • 77.11 (n)
lizard
(Anolis carolinensis)
Reptilia DUS1L 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dus1l 34
  • 74.83 (n)
Str.1993 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24034 34
zebrafish
(Danio rerio)
Actinopterygii dus1l 34 35
  • 72.71 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG3645 34 35
  • 60.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008484 34
  • 60.03 (n)
worm
(Caenorhabditis elegans)
Secernentea F36A2.2 34 35
  • 45.88 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS1 35 37
  • 38 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G67220 34
  • 53.22 (n)
rice
(Oryza sativa)
Liliopsida Os06g0712900 34
  • 53.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6459 35
  • 53 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8130 34
Species where no ortholog for DUS1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUS1L Gene

ENSEMBL:
Gene Tree for DUS1L (if available)
TreeFam:
Gene Tree for DUS1L (if available)

Paralogs for DUS1L Gene

Pseudogenes.org Pseudogenes for DUS1L Gene

genes like me logo Genes that share paralogs with DUS1L: view

No data available for Paralogs for DUS1L Gene

Variants for DUS1L Gene

Sequence variations from dbSNP and Humsavar for DUS1L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000871419 -- 82,065,975(+) GAGGG(A/G)TCGGG upstream-variant-2KB
rs1000903772 -- 82,065,025(+) GGGTG(C/T)GGCTC nc-transcript-variant, reference, missense
rs1001096022 -- 82,065,260(+) GACCT(A/C/T)GGGGG intron-variant
rs1001435731 -- 82,059,088(+) CAGCC(C/T)TATCT intron-variant
rs1001618553 -- 82,059,409(+) TGTCA(A/G)AGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUS1L Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv457975 CNV loss 19166990
nsv457976 CNV gain 19166990
nsv470620 CNV loss 18288195
nsv470621 CNV gain 18288195
nsv576183 CNV loss 21841781
nsv576187 CNV gain 21841781
nsv576188 CNV loss 21841781
nsv952392 CNV deletion 24416366

Variation tolerance for DUS1L Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUS1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUS1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUS1L Gene

Disorders for DUS1L Gene

Relevant External Links for DUS1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUS1L

No disorders were found for DUS1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUS1L Gene

Publications for DUS1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64

Products for DUS1L Gene

Sources for DUS1L Gene

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