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Aliases for DUS1L Gene

Aliases for DUS1L Gene

  • Dihydrouridine Synthase 1-Like (S. Cerevisiae) 2 3
  • TRNA-Dihydrouridine(16/17) Synthase [NAD(P)(+)]-Like 3
  • TRNA-Dihydrouridine Synthase 1-Like 4
  • EC 1.3.1.- 4
  • PP3111 3
  • DUS1 3

External Ids for DUS1L Gene

Summaries for DUS1L Gene

GeneCards Summary for DUS1L Gene

DUS1L (Dihydrouridine Synthase 1-Like (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include flavin adenine dinucleotide binding and tRNA dihydrouridine synthase activity.

UniProtKB/Swiss-Prot for DUS1L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS1L Gene

Genomics for DUS1L Gene

Genomic Location for DUS1L Gene

Start:
82,057,506 bp from pter
End:
82,065,887 bp from pter
Size:
8,382 bases
Orientation:
Minus strand

Genomic View for DUS1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS1L Gene

Regulatory Elements for DUS1L Gene

Proteins for DUS1L Gene

  • Protein details for DUS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1R4-DUS1L_HUMAN
    Recommended name:
    tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
    Protein Accession:
    Q6P1R4
    Secondary Accessions:
    • A6NHV4
    • Q96AI3

    Protein attributes for DUS1L Gene

    Size:
    473 amino acids
    Molecular mass:
    53230 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for DUS1L Gene

Proteomics data for DUS1L Gene at MOPED

Post-translational modifications for DUS1L Gene

No data available for DME Specific Peptides for DUS1L Gene

Domains for DUS1L Gene

Protein Domains for DUS1L Gene

UniProtKB/Swiss-Prot:

DUS1L_HUMAN
Family:
  • Belongs to the Dus family. Dus1 subfamily.:
    • Q6P1R4
genes like me logo Genes that share domains with DUS1L: view

No data available for Gene Families for DUS1L Gene

Function for DUS1L Gene

Molecular function for DUS1L Gene

UniProtKB/Swiss-Prot Function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS1L Gene

Gene Ontology (GO) - Molecular Function for DUS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017150 tRNA dihydrouridine synthase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with DUS1L: view

miRNA for DUS1L Gene

miRTarBase miRNAs that target DUS1L

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DUS1L Gene

Localization for DUS1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUS1L Gene COMPARTMENTS Subcellular localization image for DUS1L gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DUS1L Gene

Pathways for DUS1L Gene

SuperPathways for DUS1L Gene

No Data Available

Interacting Proteins for DUS1L Gene

Gene Ontology (GO) - Biological Process for DUS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS1L: view

No data available for Pathways by source for DUS1L Gene

Compounds for DUS1L Gene

(2) HMDB Compounds for DUS1L Gene

Compound Synonyms Cas Number PubMed IDs
5,6-Dihydrouridine
  • 5,6-Dihydrouridine
5627-05-4
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
genes like me logo Genes that share compounds with DUS1L: view

Transcripts for DUS1L Gene

Unigene Clusters for DUS1L Gene

Dihydrouridine synthase 1-like (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUS1L Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a ·
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: - -
SP7:
SP8: - -
SP9:
SP10:
SP11:

ExUns: 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DUS1L Gene

GeneLoc Exon Structure for
DUS1L
ECgene alternative splicing isoforms for
DUS1L

Expression for DUS1L Gene

mRNA expression in normal human tissues for DUS1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUS1L Gene

SOURCE GeneReport for Unigene cluster for DUS1L Gene Hs.514599

genes like me logo Genes that share expressions with DUS1L: view

Orthologs for DUS1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUS1L 36
  • 99.22 (n)
  • 99.79 (a)
DUS1L 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUS1L 36
  • 88.75 (n)
  • 93.33 (a)
DUS1L 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUS1L 36
  • 90.35 (n)
  • 93.45 (a)
DUS1L 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dus1l 36
  • 85.34 (n)
  • 91.33 (a)
Dus1l 16
Dus1l 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUS1L 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pp3111 36
  • 84.87 (n)
  • 90.09 (a)
chicken
(Gallus gallus)
Aves DUS1L 36
  • 77.11 (n)
  • 82.94 (a)
lizard
(Anolis carolinensis)
Reptilia DUS1L 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24034 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dus1l 36
  • 74.83 (n)
  • 82.02 (a)
Str.1993 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
dus1l 36
  • 72.71 (n)
  • 76.83 (a)
dus1l 37
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008484 36
  • 60.03 (n)
  • 52.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3645 36
  • 60.14 (n)
  • 54.21 (a)
CG3645 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F36A2.2 36
  • 45.88 (n)
  • 43.29 (a)
F36A2.2 37
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS1 37
  • 38 (a)
OneToOne
DUS1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G67220 36
  • 53.22 (n)
  • 47.59 (a)
rice
(Oryza sativa)
Liliopsida Os06g0712900 36
  • 53.64 (n)
  • 49.46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8130 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6459 37
  • 53 (a)
OneToOne
Species with no ortholog for DUS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUS1L Gene

ENSEMBL:
Gene Tree for DUS1L (if available)
TreeFam:
Gene Tree for DUS1L (if available)

Paralogs for DUS1L Gene

Selected SIMAP similar genes for DUS1L Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for DUS1L Gene

genes like me logo Genes that share paralogs with DUS1L: view

No data available for Paralogs for DUS1L Gene

Variants for DUS1L Gene

Sequence variations from dbSNP and Humsavar for DUS1L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4280314 -- 82,058,576(+) ACCCC(A/C)ACCCA intron-variant, reference, missense
rs4531805 -- 82,063,098(+) GGCAG(C/T)CCGGG intron-variant
rs4606789 -- 82,066,115(+) GTTCG(A/C)ATTGG upstream-variant-2KB
rs8068632 -- 82,064,391(+) AAAGC(C/T)GGGAG intron-variant
rs8068796 -- 82,064,485(+) ATCTC(C/T)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUS1L Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv909166 CNV Loss 21882294
nsv457975 CNV Loss 19166990
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
dgv3347n71 CNV Loss 21882294
nsv909181 CNV Loss 21882294
dgv3349n71 CNV Loss 21882294
nsv457976 CNV Gain 19166990
nsv470621 CNV Gain 18288195
nsv909186 CNV Loss 21882294
dgv3350n71 CNV Loss 21882294
nsv909188 CNV Loss 21882294
dgv3351n71 CNV Loss 21882294
dgv3352n71 CNV Loss 21882294
nsv909192 CNV Gain 21882294
dgv3353n71 CNV Loss 21882294

Relevant External Links for DUS1L Gene

HapMap Linkage Disequilibrium report
DUS1L

Disorders for DUS1L Gene

No disorders were found for DUS1L Gene.

No data available for UniProtKB/Swiss-Prot for DUS1L Gene

Publications for DUS1L Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for DUS1L Gene

Sources for DUS1L Gene

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