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Aliases for DUPD1 Gene

Aliases for DUPD1 Gene

  • Dual Specificity Phosphatase And Pro Isomerase Domain Containing 1 2 3
  • Dual Specificity Phosphatase 27 3 4
  • DUSP27 3 4
  • Atypical Dual-Specific Protein Phosphatase 3
  • Dual Specificity Phosphatase DUPD1 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • FMDSP 3

External Ids for DUPD1 Gene

Previous GeneCards Identifiers for DUPD1 Gene

  • GC10M076142
  • GC10M076467
  • GC10U900628
  • GC10M076797
  • GC10M070796

Summaries for DUPD1 Gene

GeneCards Summary for DUPD1 Gene

DUPD1 (Dual Specificity Phosphatase And Pro Isomerase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP26.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUPD1 Gene

Genomics for DUPD1 Gene

Regulatory Elements for DUPD1 Gene

Genomic Location for DUPD1 Gene

Start:
75,037,472 bp from pter
End:
75,073,625 bp from pter
Size:
36,154 bases
Orientation:
Minus strand

Genomic View for DUPD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUPD1 Gene

Proteins for DUPD1 Gene

  • Protein details for DUPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68J44-DUPD1_HUMAN
    Recommended name:
    Dual specificity phosphatase DUPD1
    Protein Accession:
    Q68J44
    Secondary Accessions:
    • B2RP93

    Protein attributes for DUPD1 Gene

    Size:
    220 amino acids
    Molecular mass:
    25336 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DUPD1 Gene

neXtProt entry for DUPD1 Gene

Proteomics data for DUPD1 Gene at MOPED

Post-translational modifications for DUPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUPD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUPD1 Gene

Domains for DUPD1 Gene

Gene Families for DUPD1 Gene

HGNC:
  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Suggested Antigen Peptide Sequences for DUPD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68J44

UniProtKB/Swiss-Prot:

DUPD1_HUMAN :
  • Q68J44
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUPD1: view

Function for DUPD1 Gene

Molecular function for DUPD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

Enzyme Numbers (IUBMB) for DUPD1 Gene

Gene Ontology (GO) - Molecular Function for DUPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with DUPD1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUPD1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DUPD1 Gene

Localization for DUPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUPD1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUPD1 Gene COMPARTMENTS Subcellular localization image for DUPD1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DUPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DUPD1: view

Pathways for DUPD1 Gene

SuperPathways for DUPD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IBA --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUPD1: view

No data available for Pathways by source for DUPD1 Gene

Transcripts for DUPD1 Gene

mRNA/cDNA for DUPD1 Gene

(4) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUPD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUPD1 Gene

No ASD Table

Relevant External Links for DUPD1 Gene

GeneLoc Exon Structure for
DUPD1
ECgene alternative splicing isoforms for
DUPD1

Expression for DUPD1 Gene

mRNA expression in normal human tissues for DUPD1 Gene

mRNA differential expression in normal tissues according to GTEx for DUPD1 Gene

This gene is overexpressed in Muscle - Skeletal (50.5).

Protein differential expression in normal tissues for DUPD1 Gene

This gene is overexpressed in Bone (58.1) and Heart (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DUPD1 Gene

SOURCE GeneReport for Unigene cluster for DUPD1 Gene Hs.535090

mRNA Expression by UniProt/SwissProt for DUPD1 Gene

Q68J44-DUPD1_HUMAN
Tissue specificity: Skeletal muscle, liver and adipose tissue.
genes like me logo Genes that share expressions with DUPD1: view

Expression partners for DUPD1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DUPD1 Gene

Orthologs for DUPD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUPD1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Dupd1 35
  • 86.33 (n)
  • 87.5 (a)
Dupd1 16
Dupd1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUPD1 35
  • 99.09 (n)
  • 98.18 (a)
DUPD1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dupd1 35
  • 85.69 (n)
  • 83.49 (a)
cow
(Bos Taurus)
Mammalia DUPD1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUPD1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUPD1 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUPD1 35
  • 71.53 (n)
  • 73.44 (a)
DUPD1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUPD1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dupd1 35
  • 68.06 (n)
  • 75.6 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:136906 35
  • 67.06 (n)
  • 60.36 (a)
DUPD1 (1 of 12) 36
  • 19 (a)
OneToMany
DUPD1 (10 of 12) 36
  • 40 (a)
OneToMany
DUPD1 (11 of 12) 36
  • 22 (a)
OneToMany
DUPD1 (12 of 12) 36
  • 20 (a)
OneToMany
DUPD1 (2 of 12) 36
  • 35 (a)
OneToMany
DUPD1 (3 of 12) 36
  • 16 (a)
OneToMany
DUPD1 (4 of 12) 36
  • 26 (a)
OneToMany
DUPD1 (5 of 12) 36
  • 55 (a)
OneToMany
DUPD1 (6 of 12) 36
  • 31 (a)
OneToMany
DUPD1 (7 of 12) 36
  • 36 (a)
OneToMany
DUPD1 (8 of 12) 36
  • 20 (a)
OneToMany
DUPD1 (9 of 12) 36
  • 22 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7378 36
  • 37 (a)
OneToMany
Species with no ortholog for DUPD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUPD1 Gene

ENSEMBL:
Gene Tree for DUPD1 (if available)
TreeFam:
Gene Tree for DUPD1 (if available)

Paralogs for DUPD1 Gene

Selected SIMAP similar genes for DUPD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUPD1: view

Variants for DUPD1 Gene

Sequence variations from dbSNP and Humsavar for DUPD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs750531 -- 75,070,387(-) TGACT(C/G)TGTGC intron-variant
rs755228 -- 75,069,616(+) AAGGC(A/G)AGGGG intron-variant
rs921325 -- 75,072,734(+) TCCTG(C/T)TCGCT intron-variant
rs921326 -- 75,072,752(+) TTTCC(A/G)CTTTC intron-variant
rs921327 -- 75,072,760(+) TTCCC(A/G)AACGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUPD1 Gene

Variant ID Type Subtype PubMed ID
nsv7188 CNV Insertion 18451855

Relevant External Links for DUPD1 Gene

HapMap Linkage Disequilibrium report
DUPD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUPD1 Gene

Disorders for DUPD1 Gene

Relevant External Links for DUPD1

Genetic Association Database (GAD)
DUPD1

No disorders were found for DUPD1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DUPD1 Gene

Publications for DUPD1 Gene

  1. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. (PMID: 17498703) Friedberg I. … Mustelin T. (FEBS Lett. 2007) 3 4 23
  2. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PMID: 19851299) Johansson A. … Gyllensten U. (Obesity (Silver Spring) 2010) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Structure of human dual-specificity phosphatase 27 at 2.38 A resolution. (PMID: 21543850) Lountos G.T. … Waugh D.S. (Acta Crystallogr. D 2011) 4
  5. The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains. (PMID: 18039372) Brenchley R. … Tabernero L. (BMC Genomics 2007) 23

Products for DUPD1 Gene

Sources for DUPD1 Gene

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