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Aliases for DUPD1 Gene

Aliases for DUPD1 Gene

  • Dual Specificity Phosphatase And Pro Isomerase Domain Containing 1 2 3 5
  • Dual Specificity Phosphatase 27 3 4
  • DUSP27 3 4
  • Atypical Dual-Specific Protein Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • FMDSP 3

External Ids for DUPD1 Gene

Previous GeneCards Identifiers for DUPD1 Gene

  • GC10M076142
  • GC10M076467
  • GC10U900628
  • GC10M076797
  • GC10M070796

Summaries for DUPD1 Gene

GeneCards Summary for DUPD1 Gene

DUPD1 (Dual Specificity Phosphatase And Pro Isomerase Domain Containing 1) is a Protein Coding gene. Diseases associated with DUPD1 include Cervix Carcinoma. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP15.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUPD1 Gene

Genomics for DUPD1 Gene

Regulatory Elements for DUPD1 Gene

Enhancers for DUPD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DUPD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUPD1 Gene

Chromosome:
10
Start:
75,037,472 bp from pter
End:
75,073,632 bp from pter
Size:
36,161 bases
Orientation:
Minus strand

Genomic View for DUPD1 Gene

Genes around DUPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUPD1 Gene

Proteins for DUPD1 Gene

  • Protein details for DUPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68J44-DUPD1_HUMAN
    Recommended name:
    Dual specificity phosphatase DUPD1
    Protein Accession:
    Q68J44
    Secondary Accessions:
    • B2RP93

    Protein attributes for DUPD1 Gene

    Size:
    220 amino acids
    Molecular mass:
    25336 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DUPD1 Gene

neXtProt entry for DUPD1 Gene

Proteomics data for DUPD1 Gene at MOPED

Post-translational modifications for DUPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUPD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUPD1 Gene

Domains & Families for DUPD1 Gene

Gene Families for DUPD1 Gene

Suggested Antigen Peptide Sequences for DUPD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68J44

UniProtKB/Swiss-Prot:

DUPD1_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUPD1: view

Function for DUPD1 Gene

Molecular function for DUPD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for DUPD1 Gene

Gene Ontology (GO) - Molecular Function for DUPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUPD1: view

Phenotypes for DUPD1 Gene

GenomeRNAi human phenotypes for DUPD1:
genes like me logo Genes that share phenotypes with DUPD1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUPD1 Gene

Localization for DUPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUPD1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUPD1 Gene COMPARTMENTS Subcellular localization image for DUPD1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DUPD1 Gene

Pathways & Interactions for DUPD1 Gene

SuperPathways for DUPD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUPD1: view

No data available for Pathways by source and SIGNOR curated interactions for DUPD1 Gene

Drugs & Compounds for DUPD1 Gene

(2) Additional Compounds for DUPD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUPD1: view

Transcripts for DUPD1 Gene

mRNA/cDNA for DUPD1 Gene

(4) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DUPD1 Gene

No ASD Table

Relevant External Links for DUPD1 Gene

GeneLoc Exon Structure for
DUPD1
ECgene alternative splicing isoforms for
DUPD1

Expression for DUPD1 Gene

mRNA expression in normal human tissues for DUPD1 Gene

mRNA differential expression in normal tissues according to GTEx for DUPD1 Gene

This gene is overexpressed in Muscle - Skeletal (x50.5).

Protein differential expression in normal tissues from HIPED for DUPD1 Gene

This gene is overexpressed in Bone (58.1) and Heart (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUPD1 Gene



SOURCE GeneReport for Unigene cluster for DUPD1 Gene Hs.535090

mRNA Expression by UniProt/SwissProt for DUPD1 Gene

Q68J44-DUPD1_HUMAN
Tissue specificity: Skeletal muscle, liver and adipose tissue.
genes like me logo Genes that share expression patterns with DUPD1: view

Protein tissue co-expression partners for DUPD1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DUPD1 Gene

Orthologs for DUPD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUPD1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Dupd1 35
  • 86.33 (n)
  • 87.5 (a)
Dupd1 16
Dupd1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUPD1 35
  • 99.09 (n)
  • 98.18 (a)
DUPD1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dupd1 35
  • 85.69 (n)
  • 83.49 (a)
cow
(Bos Taurus)
Mammalia DUPD1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUPD1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUPD1 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUPD1 35
  • 71.53 (n)
  • 73.44 (a)
DUPD1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUPD1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dupd1 35
  • 68.06 (n)
  • 75.6 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:136906 35
  • 67.06 (n)
  • 60.36 (a)
DUPD1 (1 of 12) 36
  • 19 (a)
OneToMany
DUPD1 (10 of 12) 36
  • 40 (a)
OneToMany
DUPD1 (11 of 12) 36
  • 22 (a)
OneToMany
DUPD1 (12 of 12) 36
  • 20 (a)
OneToMany
DUPD1 (2 of 12) 36
  • 35 (a)
OneToMany
DUPD1 (3 of 12) 36
  • 16 (a)
OneToMany
DUPD1 (4 of 12) 36
  • 26 (a)
OneToMany
DUPD1 (5 of 12) 36
  • 55 (a)
OneToMany
DUPD1 (6 of 12) 36
  • 31 (a)
OneToMany
DUPD1 (7 of 12) 36
  • 36 (a)
OneToMany
DUPD1 (8 of 12) 36
  • 20 (a)
OneToMany
DUPD1 (9 of 12) 36
  • 22 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7378 36
  • 37 (a)
OneToMany
Species with no ortholog for DUPD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUPD1 Gene

ENSEMBL:
Gene Tree for DUPD1 (if available)
TreeFam:
Gene Tree for DUPD1 (if available)

Paralogs for DUPD1 Gene

(4) SIMAP similar genes for DUPD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUPD1: view

Variants for DUPD1 Gene

Sequence variations from dbSNP and Humsavar for DUPD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs16931938 - 75,043,809(+) GTCGC(G/T)TAGCG reference, missense
rs11594934 - 75,058,319(+) CTCAT(C/T)GCCAA reference, missense
rs1868624 -- 75,037,902(+) ACCAG(C/T)TGCTT reference, synonymous-codon
rs1972997 -- 75,070,006(+) GATCA(C/T)GCCAC intron-variant
rs1993005 -- 75,058,179(+) GAAGG(C/T)AAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUPD1 Gene

Variant ID Type Subtype PubMed ID
nsv7188 CNV Insertion 18451855

Variation tolerance for DUPD1 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DUPD1 Gene

Disorders for DUPD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUPD1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cervix carcinoma
  • cancer of cervix
- elite association - COSMIC cancer census association via MalaCards
Search DUPD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUPD1

Genetic Association Database (GAD)
DUPD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUPD1
genes like me logo Genes that share disorders with DUPD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUPD1 Gene

Publications for DUPD1 Gene

  1. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. (PMID: 17498703) Friedberg I. … Mustelin T. (FEBS Lett. 2007) 3 4 23 67
  2. Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. (PMID: 25390645) Otowa T. … Hettema J.M. (PLoS ONE 2014) 3
  3. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PMID: 19851299) Johansson A. … Gyllensten U. (Obesity (Silver Spring) 2010) 3
  4. Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR. (PMID: 18505570) Henkens R. … Rahmouni S. (BMC Cancer 2008) 23
  5. The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains. (PMID: 18039372) Brenchley R. … Tabernero L. (BMC Genomics 2007) 23

Products for DUPD1 Gene

Sources for DUPD1 Gene

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