Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUOXA1 Gene

protein-coding   GIFtS: 45
GCID: GC15M045409

dual oxidase maturation factor 1

 Explore 6 diseases affiliated with
DUOXA1 via our new
 Human Malady Compendium 
Biological research products
for DUOXA1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Dual Oxidase Maturation Factor 11 2     Dual Oxidase Maturation Factor 1 Alpha2
NIP1 2 3     Dual Oxidase Maturation Factor 1 Beta2
NUMBIP1 2 3     Dual Oxidase Maturation Factor 1 Delta2
Mol1     Dual Oxidase Maturation Factor 1 Gamma2
Dual Oxidase Activator 12 3     Homolog Of Drosophila Numb-Interacting Protein2
FLJ323341     Numb-Interacting Protein3

External Ids:    HGNC: 265071   Entrez Gene: 905272   Ensembl: ENSG000001402547   OMIM: 6127715   UniProtKB: Q1HG433   

Export aliases for DUOXA1 gene to outside databases

Previous GC identifers: GC15M043198 GC15M022233


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUOXA1:
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for
thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively,
which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator
or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the
DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained
in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is
not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of
the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor
involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: DOXA1_HUMAN, Q1HG43
Function: May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of
functional DUOX1 (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUOXA1 gene promoter:
         GR   c-Fos   p53   AP-1   ATF-2   IRF-1   C/EBPalpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUOXA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUOXA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUOXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.1

DUOXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUOXA1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M045409:  view genomic region     (about GC identifiers)

Start:
45,409,569 bp from pter      End:
45,422,136 bp from pter
Size:
12,568 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DOXA1_HUMAN, Q1HG43 (See protein sequence)
Recommended Name: Dual oxidase maturation factor 1  
Size: 343 amino acids; 37815 Da
Subunit: May interact with NUMB
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q8N6K9 Q96MI4
Alternative splicing: 3 isoforms:  Q1HG43-1   Q1HG43-2   Q1HG43-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DUOXA1: NX_Q1HG43

DUOXA1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (6 alternative transcripts): 
NP_001263193.1  NP_001263194.1  NP_001263195.1  NP_001263196.1  NP_001263197.1  NP_653166.2  

ENSEMBL proteins: 
 ENSP00000267803   ENSP00000453569   ENSP00000454019   ENSP00000415512   ENSP00000453614  
 ENSP00000453836   ENSP00000454084   ENSP00000454117   ENSP00000453809   ENSP00000452782  
 ENSP00000453295   ENSP00000452795   ENSP00000453217  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
OriGene Custom Protein Services for DUOXA1 
GenScript Custom Purified and Recombinant Proteins Services for DUOXA1
Novus Biologicals DUOXA1 Proteins
Novus Biologicals DUOXA1 Lysate
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for DUOXA1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane IEA--
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--


DUOXA1 for ontologies           About GeneDecksing



DUOXA1 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for DUOXA1 
GenScript Custom Superior Antibodies Services for DUOXA1
Novus Biologicals DUOXA1 Antibodies
Search for Antibodies for DUOXA1 at Abcam  
Uscn Antibodies for DUOXA1
Search ThermoFisher Antibodies for DUOXA1

Assay Products for DUOXA1: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for DUOXA1
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for DUOXA1


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DUOXA1 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR018469 Dual_oxidase_maturation_fac

Graphical View of Domain Structure for InterPro Entry Q1HG43

ProtoNet protein and cluster: Q1HG43

UniProtKB/Swiss-Prot: DOXA1_HUMAN, Q1HG43
Similarity: Belongs to the DUOXA family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: DOXA1_HUMAN, Q1HG43
Function: May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of
functional DUOX1 (Probable)

miRNA
Products:
    
Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUOXA1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DUOXA1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUOXA1 (see all 7)
OriGene shRNA RFP: DUOXA1
OriGene siRNA: DUOXA1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUOXA1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DUOXA1

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUOXA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUOXA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: DUOXA1 (NM_144565)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUOXA1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUOXA1 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DUOXA1
Search LifeMap BioReagents cell lines for DUOXA1

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUOXA1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----


DUOXA1 for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-out Duoxa1tm1Lex for DUOXA1
     1 MGI phenotypic allele for Duoxa1 (no phenotypes)

DUOXA1 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUOXA1

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0015031protein transport IEA--
GO:0045666positive regulation of neuron differentiation IEA--
GO:2000379positive regulation of reactive oxygen species metabolic process IEA--


DUOXA1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DUOXA1
Search CenterWatch for drugs/clinical trials and news about DUOXA1 / DOXA1 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DUOXA1 gene (6 alternative transcripts): 
NM_001276264.1  NM_001276265.1  NM_001276266.1  NM_001276267.1  NM_001276268.1  NM_144565.3  

Unigene Cluster for DUOXA1:

Dual oxidase maturation factor 1
Hs.356664  [show with all ESTs]
Unigene Representative Sequence: AK056896
15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000267803(uc001zup.3) ENST00000559014(uc010uem.2 uc010bec.3)
ENST00000558996(uc010bed.1) ENST00000430224 ENST00000559013(uc001zuq.1)
ENST00000558422(uc001zur.1) ENST00000560572 ENST00000558326 ENST00000559988
ENST00000559226 ENST00000558377 ENST00000559644 ENST00000558851 ENST00000559407
ENST00000558976

miRNA
Products:
     
Browse 3'-UTR reporter clones for miRNA target validation
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUOXA1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DUOXA1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUOXA1 (see all 7)
OriGene shRNA RFP: DUOXA1
OriGene siRNA: DUOXA1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUOXA1
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUOXA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUOXA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: DUOXA1 (NM_144565)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUOXA1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUOXA1 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUOXA1
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUOXA1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUOXA1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUOXA1

Additional cDNA sequence: 

AK056896.1 AK292771.1 BC020841.1 BC029819.1 DQ489735.1 EU927394.1 EU927395.1 EU927396.1 
EU927397.1 

10 DOTS entries:

DT.99939778  DT.75102990  DT.121016711  DT.91660041  DT.97836325  DT.121016596  DT.121016602  DT.121016767 
DT.97803223  DT.423397 

24/27 AceView cDNA sequences (see all 27):

CB850544 CA444325 BC029819 NM_144565 CB305399 AK056896 BC020841 BM977797 
AL709690 CD511927 AI924216 BM977010 AL709691 BQ017315 BG536379 AI653921 
AA630445 AI572329 BM973444 W80832 CA429351 BF843140 AK027187 BI821671 

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for DUOXA1 (see all 9)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9
SP1:                                                                                                                              
SP2:                    -     -     -           -     -     -                                                                     
SP3:                          -                 -     -     -                                                                     
SP4:                                -           -           -                                                                     
SP5:                                -           -     -     -                                                                     


ECgene alternative splicing isoforms for DUOXA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DUOXA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACACGGCA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See DUOXA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUOXA1

SOURCE GeneReport for Unigene cluster: Hs.356664

UniProtKB/Swiss-Prot: DOXA1_HUMAN, Q1HG43
Tissue specificity: Specifically expressed in thyroid gland. Also detected in esophagus

    SABiosciences Custom PCR Arrays for DUOXA1
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUOXA1
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUOXA1
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUOXA1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUOXA1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUOXA1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DUOXA1 gene from 6/16 species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Duoxa11 , 5 dual oxidase maturation factor 11, 5 84.8(n)1
84.5(a)1
  2 (60.62 cM)5
2136961  NM_145395.21  NP_663370.21 
 1223021915 
chicken
(Gallus gallus)
Aves DUOXA11 dual oxidase maturation factor 1 64.26(n)
54.51(a)
  427484  XM_425055.2  XP_425055.2 
lizard
(Anolis carolinensis)
Reptilia --
--
45(a)
1 → many
GL343490.1(227341-236741)
zebrafish
(Danio rerio)
Actinopterygii CABZ01038908.16
--
40(a)
1 → many
25(32922750-32933968)
fruit fly
(Drosophila melanogaster)
Insecta mol1 moladietz 44.12(n)
34.11(a)
  34872  NM_001042898.1  NP_001036363.1 
worm
(Caenorhabditis elegans)
Secernentea C06E1.31 Protein C06E1.3 45.88(n)
36.53(a)
  182313  NM_066485.4  NP_498886.2 


ENSEMBL Gene Tree for DUOXA1 (if available)
TreeFam Gene Tree for DUOXA1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for DUOXA1 gene
DUOXA22  
2 SIMAP similar genes for DUOXA1 using alignment to 11 protein entries:     DOXA1_HUMAN (see all proteins):
NIP    DUOXA2

DUOXA1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/30 NCBI SNPs in DUOXA1 are shown (see all 30    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs47745181,2
C,F,H,pathogenic80148334(+) CAGTAC/G/TGGCGC 1 -- int17NS EA EU 1179
rs13476321,2
C,H--22233655(+) TCCGCC/ATAGGC 1 -- int14Minor allele frequency- A:0.00NS EA 420
rs607311281,2
C,F,--22235053(+) GTACCA/GAAAGG 1 -- int11Minor allele frequency- G:0.20WA 118
rs1119058761,2
--22235194(+) GAAGTG/TAGGTT 1 -- int11Minor allele frequency- T:0.50CSA 2
rs752307961,2
--22235213(+) TAGCAA/TCTTGA 1 -- int10--------
rs798978091,2
C,--22235739(+) GGGCCA/CCCGCC 2 G V mis10--------
rs169776871,2
C,F,H,--22235826(+) CTGCCG/AAGGAT 1 -- int19Minor allele frequency- A:0.10NA NS EA CSA WA 680
rs1114726601,2
--22236214(+) GGTATC/TTGGAG 1 -- int11Minor allele frequency- T:0.50CSA 2
rs802775941,2
F,--22236328(+) AGGAGG/TGGGGG 1 -- int11Minor allele frequency- T:0.03WA 118
rs13701141,2
C,F,A,H,--45409196(+) CTTTGG/ACGCTG 1 -- int117Minor allele frequency- A:0.01NS EA NA WA CSA 795

HapMap Linkage Disequilibrium report for DUOXA1 (45409569 - 45422136 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for DUOXA1
     1 CNV: 3961
     6 Indels: 87668 76962 76959 87667 76961 76960

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUOXA1
DNA2.0 Custom Variant and Variant Library Synthesis for DUOXA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DUOXA1 for disorders           About GeneDecksing

OMIM gene information: 612771    OMIM disorders: --

6 diseases for DUOXA1:    About MalaCards
dyshormonogenic goiter    aortic valve insufficiency    congenital hypothyroidism    hypothyroidism
breast cancer    thyroiditis

2 diseases from the University of Copenhagen DISEASES database for DUOXA1:
Dyshormonogenic goiter     Congenital hypothyroidism
Human Genome Epidemiology (HuGE) Navigator: DUOXA1 (2 documents)

Export disorders for DUOXA1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for DUOXA1 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with DUOXA1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent. (PubMed id 16651268)1, 2, 3 Grasberger H. and Refetoff S. (2006)
  2. A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division. (PubMed id 14670962)1, 2, 9 Qin H.... Li S.S.-C. (2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. Sexual dimorphism of thyroid reactive oxygen species p roduction due to higher NADPH oxidase 4 expression in female thyroid glands. (PubMed id 23033809)1 Fortunato R.S....Carvalho D.P. (2013)
  6. Thyroid hydrogen peroxide production is enhanced by th e Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidas e 2and its maturation factorDUOXA2. (PubMed id 23010498)1 Raad H....De Deken X. (2013)
  7. Regulation of dual oxidase expression and H2O2 product ion by thyroglobulin. (PubMed id 22874065)1 Yoshihara A....Suzuki K. (2012)
  8. Regulation of dual oxidase (DUOX) expression and H2O2 production by thyroglobulin. (PubMed id 22612456)1 Yoshihara A....Suzuki K. (2012)
  9. The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA. (PubMed id 22814254)1 Hoste C....De Deken X. (2012)
  10. p53-mediated regulation of neuronal differentiation vi a regulation of dual oxidase maturation factor 1. (PubMed id 21362455)1 Ostrakhovitch E.A. and Semenikhin O.A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 90527 HGNC: 26507 AceView: NIP Ensembl:ENSG00000140254 euGenes: HUgn90527
ECgene: DUOXA1 H-InvDB: DUOXA1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for DUOXA1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for DUOXA1 gene:
Search GeneIP for patents involving DUOXA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
 Browse OriGene Antibodies   OriGene shRNA RFP for DUOXA1  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUOXA1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUOXA1  
 Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for DUOXA1   Browse 3'-UTR reporter clones for miRNA target validation  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUOXA1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUOXA1  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DUOXA1   OriGene Custom Protein Services for DUOXA1  
 OriGene Custom Immunoassay Development  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUOXA1
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUOXA1
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUOXA1
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUOXA1
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUOXA1
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUOXA1
 GenScript Custom Purified and Recombinant Proteins Services for DUOXA1 GenScript cDNA clones with any tag delivered in your preferred vector for DUOXA1
 GenScript Custom Assay Services for DUOXA1 GenScript Custom Superior Antibodies Services for DUOXA1
 GenScript Custom overexpressing Cell Line Services for DUOXA1 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in DUOXA1 promoter
 Search Chromatin IP Primers for DUOXA1
 RT2 qPCR Primer Assay in human, mouse, rat DUOXA1
 Search GNC Networks for DUOXA1
 SABiosciences Custom PCR Arrays for DUOXA1
 Search Tocris compounds for DUOXA1
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 DUOXA1 antibodies
 DUOXA1 proteins
 DUOXA1 lysates
 Search for Antibodies for DUOXA1 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for DUOXA1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 DUOXA1 Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for DUOXA1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUOXA1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for DUOXA1
 SwitchGear Promoter luciferase reporter plasmids for DUOXA1
 Search ThermoFisher Antibodies for DUOXA1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUOXA1
       
GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category
VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DUOXA1 gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4