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DUOXA1 Gene

protein-coding   GIFtS: 48
GCID: GC15M045409

Dual Oxidase Maturation Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Oxidase Maturation Factor 11 2     Dual Oxidase Maturation Factor 1 Delta2
Dual Oxidase Activator 12 3     Dual Oxidase Maturation Factor 1 Gamma2
NIP2 3     Homolog Of Drosophila Numb-Interacting Protein2
NUMBIP2 3     mol2
Dual Oxidase Maturation Factor 1 Alpha2     Numb-Interacting Protein3
Dual Oxidase Maturation Factor 1 Beta2     

External Ids:    HGNC: 265071   Entrez Gene: 905272   Ensembl: ENSG000001402547   OMIM: 6127715   UniProtKB: Q1HG433   

Export aliases for DUOXA1 gene to outside databases

Previous GC identifers: GC15M043198 GC15M022233


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUOXA1 Gene:
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for
thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively,
which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1
activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the
transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed
with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of
this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid
hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This
protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple
alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2013)

GeneCards Summary for DUOXA1 Gene:
DUOXA1 (dual oxidase maturation factor 1) is a protein-coding gene. Diseases associated with DUOXA1 include dyshormonogenic goiter, and aortic valve insufficiency. An important paralog of this gene is DUOXA2.

UniProtKB/Swiss-Prot: DOXA1_HUMAN, Q1HG43
Function: May be required for the maturation and the transport from the endoplasmic reticulum to the plasma
membrane of functional DUOX1 (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUOXA1 gene promoter:
         GR   c-Fos   p53   AP-1   ATF-2   IRF-1   C/EBPalpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUOXA1 promoter sequence
   Search Chromatin IP Primers for DUOXA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUOXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.1

DUOXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUOXA1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M045409:  view genomic region     (about GC identifiers)

Start:
45,409,569 bp from pter      End:
45,422,136 bp from pter
Size:
12,568 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DOXA1_HUMAN, Q1HG43 (See protein sequence)
Recommended Name: Dual oxidase maturation factor 1  
Size: 343 amino acids; 37815 Da
Subunit: May interact with NUMB
Secondary accessions: Q8N6K9 Q96MI4
Alternative splicing: 3 isoforms:  Q1HG43-1   Q1HG43-2   Q1HG43-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DUOXA1: NX_Q1HG43

Explore proteomics data for DUOXA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn84, Asn109, Asn121

  • See DUOXA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001263193.1  NP_001263194.1  NP_001263195.1  NP_001263196.1  NP_001263197.1  NP_653166.2  

    ENSEMBL proteins: 
     ENSP00000267803   ENSP00000453569   ENSP00000454019   ENSP00000415512   ENSP00000453614  
     ENSP00000453836   ENSP00000454084   ENSP00000454117   ENSP00000453809   ENSP00000452782  
     ENSP00000453295   ENSP00000452795   ENSP00000453217  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018469 Dual_oxidase_maturation_fac

    Graphical View of Domain Structure for InterPro Entry Q1HG43

    ProtoNet protein and cluster: Q1HG43

    UniProtKB/Swiss-Prot: DOXA1_HUMAN, Q1HG43
    Similarity: Belongs to the DUOXA family


    DUOXA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOXA1_HUMAN, Q1HG43
    Function: May be required for the maturation and the transport from the endoplasmic reticulum to the plasma
    membrane of functional DUOX1 (Probable)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    DUOXA1 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Duoxa1):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  limbs/digits/tail  mortality/aging  nervous system  respiratory system 
     skeleton  vision/eye 

    DUOXA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DUOXA1: Duoxa1tm1Lex Duoxa1/Duoxa2Duoxa1/tm1.1Sref

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUOXA1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUOXA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUOXA1

    miRNA
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    miRTarBase miRNAs that target DUOXA1:
    hsa-mir-335-5p (MIRT017747)

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUOXA1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DOXA1_HUMAN, Q1HG43: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum2
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    DUOXA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DUOXA1
    Interactions:

        Search GeneGlobe Interaction Network for DUOXA1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for DUOXA1 (ENSP000002678034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICKENSP000002630434STRING: ENSP00000263043
    MOKENSP000003553044STRING: ENSP00000355304
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0045666positive regulation of neuron differentiation IEA--
    GO:2000379positive regulation of reactive oxygen species metabolic process IEA--

    DUOXA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUOXA1 (DOXA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DUOXA1 gene (6 alternative transcripts): 
    NM_001276264.1  NM_001276265.1  NM_001276266.1  NM_001276267.1  NM_001276268.1  NM_144565.3  

    Unigene Cluster for DUOXA1:

    Dual oxidase maturation factor 1
    Hs.356664  [show with all ESTs]
    Unigene Representative Sequence: NM_001276267
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267803(uc001zup.3) ENST00000559014(uc010uem.2 uc010bec.3)
    ENST00000558996(uc010bed.1) ENST00000430224 ENST00000559013(uc001zuq.1)
    ENST00000558422(uc001zur.1) ENST00000560572 ENST00000558326 ENST00000559988
    ENST00000559226 ENST00000558377 ENST00000559644 ENST00000558851 ENST00000559407
    ENST00000558976
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUOXA1
      QuantiTect SYBR Green Assays in human, mouse, rat DUOXA1
      QuantiFast Probe-based Assays in human, mouse, rat DUOXA1

    Additional mRNA sequence: 

    AK056896.1 AK292771.1 BC020841.1 BC029819.1 DQ489735.1 EU927394.1 EU927395.1 EU927396.1 
    EU927397.1 

    7 DOTS entries:

    DT.99939778  DT.75102990  DT.91660041  DT.97836325  DT.121016596  DT.97803223  DT.423397 

    Selected AceView cDNA sequences (see all 27):

    AK056896 NM_144565 CA444325 CB850544 BC029819 CB305399 AI653921 AL709690 
    AI924216 BG536379 BM977797 BC020841 BM977010 BQ017315 CD511927 AA630445 
    AL709691 AI572329 W80832 BM973444 BF843140 CA429351 AK027187 BI821671 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DUOXA1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                                                                                              
    SP2:                    -     -     -           -     -     -                                                                     
    SP3:                          -                 -     -     -                                                                     
    SP4:                                -           -           -                                                                     
    SP5:                                -           -     -     -                                                                     


    ECgene alternative splicing isoforms for DUOXA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUOXA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACACGGCA
    DUOXA1 Expression
    About this image


    DUOXA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Thyroid (Endocrine System)
     
     Esophagus (Gastrointestinal Tract)
    DUOXA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUOXA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356664

    UniProtKB/Swiss-Prot: DOXA1_HUMAN, Q1HG43
    Tissue specificity: Specifically expressed in thyroid gland. Also detected in esophagus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUOXA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DUOXA1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Duoxa11 , 5 dual oxidase maturation factor 11, 5 84.46(n)1
    83.87(a)1
      2 (60.62 cM)5
    2136961  NM_145395.21  NP_663370.21 
     1223021915 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    48(a)
    43(a)
    many ↔ many
    many ↔ many
    10(529850-533783)
    10(536876-541826)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    1 → many
    GL343490.1(227341-238894)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia duoxa11 dual oxidase maturation factor 1 58.1(n)
    49.65(a)
      780018  NM_001079095.1  NP_001072563.1 
    zebrafish
    (Danio rerio)
    Actinopterygii DUOXA16
    dual oxidase maturation factor 1
    40(a)
    1 → many
    25(32922750-32933968) ENSDARG00000078962
    fruit fly
    (Drosophila melanogaster)
    Insecta mol1 moladietz 45.36(n)
    35.05(a)
      34872  NM_001042897.2  NP_001036362.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C06E1.31 C06E1.3 46.25(n)
    36.53(a)
      182313  NM_066485.5  NP_498886.2 


    ENSEMBL Gene Tree for DUOXA1 (if available)
    TreeFam Gene Tree for DUOXA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUOXA1 gene
    DUOXA22  
    1 SIMAP similar gene for DUOXA1 using alignment to 12 protein entries:     DOXA1_HUMAN (see all proteins):
    DUOXA2

    DUOXA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUOXA1 (see all 265)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2002566391,2
    --25478028(+) ATGTCA/CTGGGA 12 Q H mis10--------
    rs1998559831,2
    C--25478039(+) CTTGGG/TACTGT 12 T P mis10--------
    rs169776861,2,,4
    C,F,H--25478042(+) GGGACT/CGTCAG 12 /S /G mis1 ese317Minor allele frequency- C:0.01NA NS EA WA EU 7441
    rs1995592251,2
    C--25478062(+) GGTAGC/TGGGGG 12 H R mis10--------
    rs1437922831,2
    C--25478109(+) ATGGGG/TTCTTC 12 E D mis10--------
    rs1488494571,2
    C--25478138(+) GAAAGC/ACTTCA 12 /A /S mis11Minor allele frequency- A:0.00NA 4536
    rs798978091,2
    C--25478170(+) GGGCCA/CCCGCC 12 G V mis10--------
    rs1860636571,2
    C--25478253(+) ACACCC/TGCCGA 6 -- int10--------
    rs169776871,2
    C,F,H--25478257(+) CTGCCG/AAGGAT 6 -- int19Minor allele frequency- A:0.10NA NS EA CSA WA 680
    rs129108071,2
    C,F,H--25478276(+) CTGGGA/TGTGTC 6 -- int18Minor allele frequency- T:0.02NS EA NA 544

    HapMap Linkage Disequilibrium report for DUOXA1 (45409569 - 45422136 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DUOXA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1002924CNV Deletion20482838
    dgv2378n71CNV Loss21882294
    nsv457125CNV Loss19166990
    nsv518213CNV Gain19592680
    dgv744e1CNV Complex17122850
    nsv7264OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612771    OMIM disorders: --

    9 diseases for DUOXA1:    
    About MalaCards
    dyshormonogenic goiter    aortic valve insufficiency    congenital hypothyroidism    goiter
    hypothyroidism    thyroiditis    neuronitis    malaria
    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for DUOXA1:
    Dyshormonogenic goiter     Congenital hypothyroidism

    DUOXA1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DUOXA1
    Human Genome Epidemiology (HuGE) Navigator: DUOXA1 (2 documents)

    Export disorders for DUOXA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUOXA1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with DUOXA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent. (PubMed id 16651268)1, 2, 3 Grasberger H. and Refetoff S. (J. Biol. Chem. 2006)
    2. A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division. (PubMed id 14670962)1, 2, 9 Qin H.... Li S.S.-C. (J. Biol. Chem. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    6. Sexual dimorphism of thyroid reactive oxygen species production due to higher NADPH oxidase 4 expression in female thyroid glands. (PubMed id 23033809)1 Fortunato R.S....Carvalho D.P. (Thyroid 2013)
    7. Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2. (PubMed id 23010498)1 Raad H....De Deken X. (amp 2013)
    8. Regulation of dual oxidase expression and H2O2 production by thyroglobulin. (PubMed id 22874065)1 Yoshihara A....Suzuki K. (Thyroid 2012)
    9. Regulation of dual oxidase (DUOX) expression and H2O2 production by thyroglobulin. (PubMed id 22612456)1 Yoshihara A....Suzuki K. (Thyroid 2012)
    10. The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA. (PubMed id 22814254)1 Hoste C....De Deken X. (Exp. Cell Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90527 HGNC: 26507 AceView: NIP Ensembl:ENSG00000140254 euGenes: HUgn90527
    ECgene: DUOXA1 H-InvDB: DUOXA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DUOXA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DUOXA1 gene:
    Search GeneIP for patents involving DUOXA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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