DUOX1 Gene
protein-coding GIFtS: 52
GCID: GC15P045422
|
|
dual oxidase 1
| |
Aliases
for DUOX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dual Oxidase 11 2 | | NADPH Thyroid Oxidase 12 3 | | THOX11 2 3 5 | | Flavoprotein NADPH Oxidase2 | | LNOX11 2 3 | | Nicotinamide Adenine Dinucleotide Phosphate Oxidase2 | | NOXEF11 2 | | DUOX3 | | Large NOX 12 3 | | EC 1.11.1.-3 | | Long NOX 12 3 | | EC 1.6.3.13 | | Thyroid Oxidase 12 3 | | |
Export aliases for DUOX1 gene to outside databasesPrevious GC identifers: GC15P040980 GC15P038469 GC15P043001 GC15P043138 GC15P043209 GC15P022246 |
Summaries
for DUOX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DUOX1:
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroidhormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complexcontains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded bythis gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homologydomain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity ofthyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Twoalternatively spliced transcript variants encoding the same protein have been described for this gene. (provided byRefSeq, Jul 2012)
UniProtKB/Swiss-Prot: DUOX1_HUMAN, Q9NRD9Function: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO andlactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense atthe surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain
Gene Wiki entry for DUOX1 (Dual oxidase 1)
|
Genomic Views
for DUOX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DUOX1 gene promoter:
GR ER-alpha p53 AP-1 GR-beta IRF-1 C/EBPalpha HEN1 PPAR-gamma1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for DUOX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUOX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.3 Ensembl cytogenetic band: 15q21.1 HGNC cytogenetic band: 15q21DUOX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P045422: view genomic region
(about GC identifiers)
Start:
|
45,422,131 bp from pter |
End:
|
45,457,774 bp from pter |
Size:
|
35,644 bases |
Orientation:
|
plus strand |
|
Proteins
for DUOX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DUOX1_HUMAN, Q9NRD9 (See
protein sequence)Recommended Name: Dual oxidase 1 precursor Size: 1551 amino acids; 177235 Da
Subunit: Interacts with TXNDC11, TPO and CYBA
Subcellular location: Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane ofepithelial cells
Developmental stage: Widely expressed in fetal tissues
Sequence caution: Sequence=AK128591; Type=Erroneous termination; Positions=967; Note=Translated as Arg;Sequence=BAD18816.1; Type=Erroneous initiation;
Secondary accessions: A6NH28 Q14C94 Q6ZMB3 Q6ZR09 Q9NZC1Alternative splicing: 2 isoforms: Q9NRD9-1 Q9NRD9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DUOX1: NX_Q9NRD9
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NRD9
DUOX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_059130.2 NP_787954.1
ENSEMBL proteins: ENSP00000317997 ENSP00000373689 ENSP00000454121 ENSP00000452623 ENSP00000454065 ENSP00000400283
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
DUOX1 for ontologies About GeneDecksing
DUOX1 Antibody Products:
Assay Products for DUOX1: |
Protein
Domains /
Families
for DUOX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DUOX1 for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry Q9NRD9ProtoNet protein and cluster: Q9NRD9 2 Blocks protein families: IPB010255 Haem peroxidase IPB013130 Ferric reductase-like transmembrane component
UniProtKB/Swiss-Prot: DUOX1_HUMAN, Q9NRD9Similarity: In the N-terminal section; belongs to the peroxidase familySimilarity: Contains 3 EF-hand domainsSimilarity: Contains 1 FAD-binding FR-type domainSimilarity: Contains 1 ferric oxidoreductase domain |
Function
for DUOX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DUOX1_HUMAN, Q9NRD9Function: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO andlactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense atthe surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domainCatalytic activity: NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2)Enzyme regulation: The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited byaminobenzohydrazideInduction: By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13Enzyme Numbers (IUBMB): EC 1.11.1.-1 EC 1.6.3.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUOX1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUOX1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for DUOX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUOX1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUOX1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
DUOX1 for ontologies About GeneDecksing
|
Pathways & Interactions
for DUOX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: DUOX1_HUMAN, Q9NRD9Pathway: Hormone biosynthesis; thyroid hormone biosynthesisInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUOX1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for DUOX1 (Q9NRD93 ENSP000003179974) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
DUOX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DUOX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DUOX1 for compounds About GeneDecksing
 Browse Tocris compounds for DUOX1
5 HMDB Compounds for DUOX1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Calcium | Ca (see all 2) | 7440-70-2 | -- | | FAD | 1H-Purin-6-amine flavin dinucleotide (see all 21) | 146-14-5 | -- | | Hydrogen peroxide | Hydrogen peroxide (see all 44) | 7722-84-1 | -- | | NAD | 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28) | 53-84-9 | -- | | NADPH | 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23) | 53-57-6 | -- |
6 Novoseek chemical compound relationships for DUOX1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nadph |
78 |
25 |
19339556 (2), 16111680 (2), 15972824 (1), 17142770 (1) (see all 16) |
| iodide |
72 |
4 |
14557483 (1), 16987011 (1), 14960641 (1) |
| h2o2 |
63.9 |
14 |
15972824 (2), 18230830 (2), 12824283 (2), 16134168 (1) (see all 10) |
| diphenyleneiodonium |
52.3 |
1 |
17337509 (1) |
| superoxide |
44.7 |
4 |
19460756 (1), 18802092 (1) |
| oxygen |
43.5 |
10 |
17142770 (2), 19074510 (1), 17220369 (1), 17218812 (1) |
Search CenterWatch for drugs/clinical trials and news about DUOX1
|
Transcripts
for DUOX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DUOX1 gene (2 alternative transcripts): NM_017434.3 NM_175940.1 Unigene Cluster for DUOX1: Dual oxidase 1 Hs.272813 [show with all ESTs]Unigene Representative Sequence: NM_01743413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321429(uc001zus.1 uc001zut.1 uc010bee.1) ENST00000389037
ENST00000558322 ENST00000561220 ENST00000558991 ENST00000561166 ENST00000559219
ENST00000557893(uc001zuu.3) ENST00000558446 ENST00000559716 ENST00000559221
ENST00000558744 ENST00000431588
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUOX1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUOX1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DUOX1 (NM_175940) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUOX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUOX1 |
Additional cDNA sequence: AF213465.1 AF230495.1 AK075268.1 AK128591.1 AK129611.1 AK172859.1 AK290372.1 AL137592.1 BC114628.1 BC114938.1 11 DOTS entries: DT.86858071 DT.91652102 DT.86995815 DT.97769689 DT.95202677 DT.91764193 DT.91849682 DT.97825157 DT.91764196 DT.91994859 DT.95102249 24/59 AceView cDNA sequences (see all 59): NM_175940 AL708623 AW188742 AL137592 NM_017434 AA331154 BF844465 AF213465 CD628230 BV197737 CD628228 AK128591 AW150028 CB996666 BF877751 AF230495 CD628226 CD628225 BI768821 BE140896 BG290606 CB850552 AK075268 BG681772
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DUOX1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DUOX1
|
Expression
for DUOX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUOX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGGTAATCC
About this image
See DUOX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUOX1
SOURCE GeneReport for Unigene cluster: Hs.272813
UniProtKB/Swiss-Prot: DUOX1_HUMAN, Q9NRD9Tissue specificity: Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed inthyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart
SABiosciences Expression via Pathway-Focused PCR Arrays including DUOX1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUOX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUOX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUOX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUOX1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUOX1 |
Orthologs
for DUOX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DUOX1 gene from 7/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DUOX26 |
Uncharacterized protein |
65(a) |
1 → many |
10(412560-429995) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
54(a) |
1 → many |
GL343490.1(251761-309268) |
zebrafish
(Danio rerio) |
Actinopterygii |
duox6 |
dual oxidase |
56(a) |
1 → many |
25(32936631-32997395) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG31313 |
superoxide-generating NADPH oxidase |
39(a) |
|
23B2 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
F56C11.13 |
-- |
34(a)
(best of 2) |
|
I(146623-154819) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RBOHB1 |
Respiratory burst oxidase-B |
43.1(n)
32.87(a) |
|
837430 NM_202070.1 NP_973799.1 |
rice
(Oryza sativa) |
Liliopsida |
----(see all 9) |
respiratory burst oxidase, putative, expressed(see all 9) |
24(a)22(a)(see all 9) |
many ↔ manymany ↔ many(see all 9) |
1(30621627-30633361) 1(35812105-35816641) |
ENSEMBL Gene Tree for DUOX1 (if available)
TreeFam Gene Tree for DUOX1 (if available) |
Paralogs
for DUOX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DUOX1 gene
- NOX12 CYBB2 NOX32 NOX42 DUOX22 NOX52
7 SIMAP similar genes for DUOX1 using alignment to 5 protein entries: DUOX1_HUMAN (see all proteins):DKFZp434L0610 DUOX2 CALM3 CALM1 CALM2 NOX3
NOX1
DUOX1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DUOX1
PGOHUM00000262060
|
Genomic Variants
for DUOX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DUOX1 (45422131 - 45457774 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DUOX1
3 CNVs: 3961 49557 76963 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUOX1 |
|
Disorders
/ Diseases
for DUOX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DUOX1 for disorders About GeneDecksing
OMIM gene information: 606758
OMIM disorders: --
17  diseases for DUOX1: About MalaCardsthyroiditis congenital hypothyroidism chronic obstructive pulmonary disease chronic granulomatous disease
hypothyroidism follicular thyroid carcinoma thyroid carcinoma hepatopulmonary syndrome
pulmonary disease alcoholic hepatitis liver disease carcinoma
alcoholism hepatocellular carcinoma lung cancer hepatitis
prostatitis
2 diseases from the University of Copenhagen DISEASES database for DUOX1:Chronic granulomatous disease Vascular disease 6 Novoseek disease relationships for DUOX1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: DUOX1 (5 documents)
Export disorders for DUOX1 gene to outside databases
|
Publications
for DUOX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DUOX1 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with DUOX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. (PubMed id 10806195)1, 2, 3, 9 De Deken X.... Miot F. (2000)
- Identification of a novel partner of duox: EFP1, a thioredoxin- related protein. (PubMed id 15561711)1, 2, 9 Wang D....Miot F. (2005)
- Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. (PubMed id 16111680)1, 2, 9 Harper R.W.... Wu R. (2005)
- Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. (PubMed id 12824283)1, 2, 9 Geiszt M.... Leto T.L. (2003)
- Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system. (PubMed id 11822874)1, 2, 9 De Deken X.... Miot F. (2002)
- Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity. (PubMed id 15972824)1, 2, 9 Ameziane-El-Hassani R.... Dupuy C. (2005)
- NADPH oxidase-dependent acid production in airway epithelial cells. (PubMed id 15210697)1, 2 Schwarzer C.... Fischer H. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox. (PubMed id 11514595)1, 2 Edens W.A....Lambeth J.D. (2001)
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External Searches for DUOX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing DUOX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing DUOX1 gene
(According to HUGE)
About This Section
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Specialized Databases showing DUOX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for DUOX1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DUOX1 gene:
Search GeneIP for patents involving DUOX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DUOX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DUOX1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUOX1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUOX1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DUOX1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUOX1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUOX1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DUOX1 | | OriGene Custom Protein Services for DUOX1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUOX1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUOX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUOX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUOX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUOX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUOX1 |
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| | | | Search Tocris compounds for DUOX1 |
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 | | | DUOX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUOX1 |
|  |  |  | | | | Search ThermoFisher Antibodies for DUOX1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUOX1 |
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