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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DTYMK Gene

protein-coding   GIFtS: 67
GCID: GC02M242634

Deoxythymidylate Kinase (Thymidylate Kinase)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Deoxythymidylate Kinase (Thymidylate Kinase)1 2     Thymidylate (DTMP) Kinase1
DTMP Kinase1 2 3     PP37312
CDC82 3     Thymidylate Kinase2
TMPK2 3     EC 2.7.4.93
TYMK2 3     

External Ids:    HGNC: 30611   Entrez Gene: 18412   Ensembl: ENSG000001683937   OMIM: 1883455   UniProtKB: P239193   
ORGUL members:         
NONCODE14:n409132      

Export aliases for DTYMK gene to outside databases

Previous GC identifers: GC02U990022 GC02P239574 GC02M242935 GC02M242335 GC02M242263 GC02M234370


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DTYMK Gene: 
DTYMK (deoxythymidylate kinase (thymidylate kinase)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with DTYMK include chickenpox, and smallpox, and among its related super-pathways are pyrimidine deoxyribonucleotides biosynthesis from CTP and Metabolic pathways. GO annotations related to this gene include thymidylate kinase activity and ATP binding.

UniProtKB/Swiss-Prot: KTHY_HUMAN, P23919
Function: Catalyzes the conversion of dTMP to dTDP

Gene Wiki entry for DTYMK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005416.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DTYMK gene promoter:
         NF-1   NF-1/L   GATA-3   Nkx2-5   Ik-3   GATA-1   AREB6   c-Rel   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DTYMK promoter sequence
   Search SABiosciences Chromatin IP Primers for DTYMK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTYMK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37

DTYMK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTYMK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M242634:  view genomic region     (about GC identifiers)

Start:
242,615,157 bp from pter      End:
242,626,406 bp from pter
Size:
11,250 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KTHY_HUMAN, P23919 (See protein sequence)
Recommended Name: Thymidylate kinase  
Size: 212 amino acids; 23819 Da
6/21 PDB 3D structures from and Proteopedia for DTYMK (see all 21):
1E2D (3D)        1E2E (3D)        1E2F (3D)        1E2G (3D)        1E2Q (3D)        1E98 (3D)    
Secondary accessions: Q6FGX1 Q9BUX4

Explore the universe of human proteins at neXtProt for DTYMK: NX_P23919

Explore proteomics data for DTYMK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P23919

  • DTYMK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DTYMK Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001158503.1  NP_036277.2  

    ENSEMBL proteins: 
     ENSP00000304802   ENSP00000383581   ENSP00000408939   ENSP00000410647   ENSP00000387379  
    Reactome Protein details: P23919
    Human Recombinant Protein Products for DTYMK: 
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    Novus Biologicals DTYMK Proteins
    Novus Biologicals DTYMK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DTYMK
    Cloud-Clone Corp. Proteins for DTYMK 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005759mitochondrial matrix IEA--
    GO:0005829cytosol TAS--

    DTYMK for ontologies           About GeneDecksing



    DTYMK Antibody Products: 
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    Cloud-Clone Corp. ELISAs for DTYMK 
    Cloud-Clone Corp. CLIAs for DTYMK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR018094 Thymidylate_kinase
     IPR027417 P-loop_NTPase
     IPR018095 Thymidylate_kin_CS

    Graphical View of Domain Structure for InterPro Entry P23919

    ProtoNet protein and cluster: P23919

    1 Blocks protein domain: IPB000062 Thymidylate kinase

    UniProtKB/Swiss-Prot: KTHY_HUMAN, P23919
    Similarity: Belongs to the thymidylate kinase family


    DTYMK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KTHY_HUMAN, P23919
    Function: Catalyzes the conversion of dTMP to dTDP
    Catalytic activity: ATP + dTMP = ADP + dTDP

         Genatlas biochemistry entry for DTYMK:
    deoxythymidylate kinase

         Enzyme Number (IUBMB): EC 2.7.4.91

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004798thymidylate kinase activity IDA8845311
    GO:0005524ATP binding IEA--
    GO:0050145nucleoside phosphate kinase activity EXP--
         
    DTYMK for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DTYMK:
     Decreased telomerase activity  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DTYMK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DTYMK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DTYMK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DTYMK 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DTYMK
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    Inhib. RNA
    Products:
        
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DTYMK (NM_012145)
    Sino Biological Human cDNA Clone for DTYMK
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTYMK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DTYMK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
    pyrimidine deoxyribonucleotides de novo biosynthesis I0.88
    pyrimidine deoxyribonucleotides de novo biosynthesis II0.73
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)0.88
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.71
    pyrimidine deoxyribonucleotides biosynthesis from CTP0.88
    superpathway of pyrimidine deoxyribonucleoside salvage0.65
    pyrimidine deoxyribonucleotide phosphorylation0.77
    Synthesis and interconversion of nucleotide di- and triphosphates0.30
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Purine metabolism
    Metabolism of nucleotides0.42
    4Purine metabolism
    Pyrimidine metabolism0.38
    5Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7 BioSystems Pathways for DTYMK (see all 7)
        superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
    superpathway of pyrimidine deoxyribonucleoside salvage
    pyrimidine deoxyribonucleotides de novo biosynthesis I
    pyrimidine deoxyribonucleotides de novo biosynthesis II


    3        Reactome Pathways for DTYMK
        Metabolism of nucleotides
    Synthesis and interconversion of nucleotide di- and triphosphates
    Metabolism

    1 PharmGKB Pathway for DTYMK
        Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    2         Kegg Pathways  (Kegg details for DTYMK):
        Pyrimidine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: KTHY_HUMAN, P23919
    Pathway: Pyrimidine metabolism; dTTP biosynthesis


    DTYMK for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DTYMK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/621 Interacting proteins for DTYMK (P239192, 3 ENSP000003048024) via UniProtKB, MINT, STRING, and/or I2D (see all 621)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL24P837312, 3MINT-7947479 I2D: score=1 
    SMARCA5O602642, 3MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7947479 I2D: score=1 
    CDK9P507502, 3, ENSP000003623614MINT-7947479 I2D: score=1 STRING: ENSP00000362361
    FEN1P397482, 3, ENSP000003054804MINT-7947479 I2D: score=1 STRING: ENSP00000305480
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006233dTDP biosynthetic process IEA--
    GO:0006235dTTP biosynthetic process IEA--
    GO:0007049cell cycle TAS8024690
    GO:0008283cell proliferation TAS8024690
    GO:0009165nucleotide biosynthetic process ----

    DTYMK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DTYMK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DTYMK (KTHY)

    7 HMDB Compounds for DTYMK    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Thymidylic acid2'-Deoxythymidine 5'-monophosphate (see all 28)365-07-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Thymidine 3',5'-cyclic monophosphate3',5'-Cyclic TMP (see all 14)6453-60-7--
    dTDPDeoxy-tdp (see all 5)491-97-4--
    dUDP2'-deoxyuridine-5'-diphosphate (see all 3)4208-67-7--
    dUMP2'-Deoxy-5'-uridylate (see all 12)964-26-1--

    9 DrugBank Compounds for DTYMK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3'-Azido-3'-Deoxythymidine-5'-Monophosphate-- --target--17139284 17016423 10592235
    P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate-- --target--17139284 17016423 10592235
    Phosphoric Acid Mono-[3-Fluoro-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahyro-Furan-2-Ylmethyl] Ester-- --target--17139284 17016423 10592235
    Thymidine-5'-Phosphate2'-Deoxythymidine 5'-monophosphate (see all 36)365-07-1target--17139284 17016423 10592235
    2',3'-Dideoxythymidine-5'-Monophosphate-- --target--17139284 17016423
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate-- --target--17139284 17016423
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423
    Phosphoric Acid Mono-[3-Amino-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester-- --target--17139284 17016423

    10/22 Novoseek inferred chemical compound relationships for DTYMK gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidylate 94.7 159 8024690 (7), 9826650 (4), 16461678 (4), 19749250 (4) (see all 77)
    aztmp 94.2 14 9826650 (3), 11071809 (2), 16248014 (1), 15134538 (1) (see all 8)
    aztdp 89.9 2 8941356 (1), 15722537 (1)
    nucleoside monophosphate 87.6 5 10873853 (1), 17999954 (1), 20065942 (1)
    triphosphate 82.7 4 11923581 (1), 15855530 (1), 20065942 (1)
    dttp 81.3 8 16103219 (3), 18523102 (1), 18413751 (1), 19296833 (1)
    zidovudine 75.6 35 11923581 (3), 18559937 (3), 9256287 (2), 11071809 (1) (see all 7)
    thymidine 74.1 31 9658118 (3), 11923581 (2), 11241312 (2), 2017365 (1) (see all 17)
    deoxycytidine 71.2 5 11275369 (1), 15748706 (1), 9658118 (1), 20516559 (1)
    nucleoside 69.1 3 16461678 (1), 17590962 (1), 19233899 (1)

    Search CenterWatch for drugs/clinical trials and news about DTYMK / KTHY

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DTYMK gene (2 alternative transcripts): 
    NM_001165031.1  NM_012145.3  

    Unigene Cluster for DTYMK:

    Deoxythymidylate kinase (thymidylate kinase)
    Hs.471873  [show with all ESTs]
    Unigene Representative Sequence: AK022132
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305784(uc010zpa.2 uc002wbz.2 uc002wca.2 uc010zpb.2)
    ENST00000400770 ENST00000445261 ENST00000432348 ENST00000420144 ENST00000493095
    ENST00000464603
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTYMK
    Sirion Biotech Customized lentivirus for stable overexpression of DTYMK 
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    Primer
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    Additional mRNA sequence: 

    AK022132.1 AK223434.1 BC001827.2 BC147006.1 BC147010.1 BC171894.1 BC171902.1 BC171903.1 
    CR541986.1 CR542015.1 NR_033255.1 X54729.1 

    18 DOTS entries:

    DT.75120001  DT.99954119  DT.97855060  DT.100028903  DT.92029550  DT.91758525  DT.86836386  DT.100641151 
    DT.100028902  DT.100764814  DT.100867068  DT.120958590  DT.95289177  DT.97766456  DT.97855061  DT.100867067 
    DT.102831795  DT.92033260 

    24/293 AceView cDNA sequences (see all 293):

    CR620414 CR606301 NM_012145 CF528035 CR542015 BM674889 BM717691 BQ229218 
    BF939159 BM552707 CR623128 BM763180 AI189369 CA489016 BU161701 CR593291 
    BX103646 CR604693 AA427389 BM046159 BU182335 CR599450 AK126180 AI096912 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DTYMK (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:                                                  -     -     -     -                                       
    SP2:                                                  -     -     -     -           -                           
    SP3:                                                  -     -     -     -     -                                 
    SP4:                                            -     -     -     -     -     -                                 
    SP5:                                            -     -     -     -     -                                       


    ECgene alternative splicing isoforms for DTYMK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DTYMK expression in normal human tissues (normalized intensities)      DTYMK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGAGCGA
    DTYMK Expression
    About this image


    DTYMK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Thalamus
             Septum   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; endothelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See DTYMK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DTYMK

    SOURCE GeneReport for Unigene cluster: Hs.471873
        SABiosciences Custom PCR Arrays for DTYMK
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DTYMK gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtymk1 , 5 deoxythymidylate kinase1, 5 82.55(n)1
    81.13(a)1
      1 (47.34 cM)5
    219151  NM_001105667.11  NP_001099137.11 
     937925765 
    chicken
    (Gallus gallus)
    Aves DTYMK6
    thymidylate kinase
    30(a)
    1 ↔ 1
    9(4282286-4287699)
    lizard
    (Anolis carolinensis)
    Reptilia DTYMK6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    3(30562834-30571520)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193822 Xenopus laevis transcribed sequence with weak similarity more 72.54(n)    BX850634.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dtymk1 deoxythymidylate kinase (thymidylate kinase) 62.74(n)
    64.15(a)
      567734  NM_001037110.1  NP_001032187.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57571 , 3 thymidylate kinase3
    CG57571
    41(a)3
    49.68(n)1
    45.19(a)1
      55B43
    370621  NM_137446.21  NP_611290.31 
    worm
    (Caenorhabditis elegans)
    Secernentea R53.21 , 3 thymidylate kinase3
    Protein R53.21
    39(a)3
    47.62(n)1
    42.36(a)1
      II(9963073-9966991)3
    1745531  NM_063750.21  NP_496151.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC8(YJR057W)4
    CDC81
    Thymidylate and uridylate kinase, functions in de novo more4
    Cdc8p1
    51.76(n)1
    52.8(a)1
      10(544062-544712)4
    8535201, 4  NP_012591.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ZEU11 protein ZEU1 (ZEUS1) 50.74(n)
    51.23(a)
      836063  NM_180891.3  NP_851222.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06399001 hypothetical protein 53.78(n)
    54.67(a)
      4344056  NM_001066953.2  NP_001060418.2 


    ENSEMBL Gene Tree for DTYMK (if available)
    TreeFam Gene Tree for DTYMK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DTYMK gene
    11 SIMAP similar genes for DTYMK using alignment to 6 protein entries:     KTHY_HUMAN (see all proteins):
    LOC727761    LINC00596    FAM175A    AURA2    ZNF564    NF2
    UTY    FAM3A    SHANK2    SEPT2    ZNF74

    DTYMK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/361 SNPs in DTYMK are shown (see all 361)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850004391,2
    --242614677(+) GGCAAC/TATAGC 3 -- int10--------
    rs46759131,2
    C,F--242614709(-) CCTGGC/GTAATT 3 -- int12Minor allele frequency- G:0.33NA 6
    rs46759121,2
    C--242614718(-) TTCACC/TGTGCC 3 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs1463681731,2
    --242614750(+) AGGAGA/GCTGAA 3 -- int10--------
    rs1924462941,2
    --242614831(+) TGGGCA/GACAGT 3 -- int10--------
    rs1381720821,2
    --242615000(+) GGCTGC/TAACTG 3 -- int10--------
    rs1131427771,2
    C--242615033(+) CTCAAC/TTAGGC 3 -- int10--------
    rs1129320131,2
    F--242615148(+) TGAAGC/TGTTCC 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs781808291,2
    C,F--242615172(+) AGGTCT/GTTTTT 3 -- ut31 nc-transcript-variant3Minor allele frequency- G:0.33NA WA 6
    rs1838308481,2
    --242615175(+) TCGTTC/TTTTAC 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for DTYMK (242615157 - 242626406 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DTYMK:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508901CNV Insertion20534489
    dgv4495n71CNV Loss21882294
    dgv4493n71CNV Loss21882294
    dgv4494n71CNV Loss21882294
    dgv4496n71CNV Loss21882294
    nsv876242CNV Loss21882294
    nsv876226CNV Loss21882294
    dgv4497n71CNV Loss21882294
    dgv165e55CNV Loss17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 188345    OMIM disorders: --

    9 diseases for DTYMK:    About MalaCards
    chickenpox    smallpox    herpes simplex    tuberculosis
    vaccinia    chronic lymphocytic leukemia    colon cancer    leukemia
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for DTYMK:
    Smallpox

    DTYMK for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    5 Novoseek inferred disease relationships for DTYMK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 52.3 23 17910427 (3), 12662932 (2), 12898625 (2), 15628853 (2) (see all 16)
    immunodeficiency 30.7 4 11923581 (1), 18559937 (1), 15722537 (1)
    herpes simplex 29.3 1 9281520 (1)
    infectious disease 23.4 1 16461678 (1)
    cancer 0 1 16461678 (1)


    Export disorders for DTYMK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DTYMK gene, integrated from 9 sources (see all 98):
    (articles sorted by number of sources associating them with DTYMK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. (PubMed id 8024690)1, 2, 3, 9 Huang S.H....Jong A. (1994)
    2. Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. (PubMed id 2017365)1, 2, 3, 9 Su J.Y. and Sclafani R.A. (1991)
    3. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. (PubMed id 12614151)1, 2, 9 Ostermann N.... Lavie A. (2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. (PubMed id 18413751)1, 9 Hu C.M. and Chang Z.F. (2008)
    6. Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases. (PubMed id 11008000)1, 9 Van Rompay A.R....Karlsson A. (2000)
    7. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1841 HGNC: 3061 AceView: DTYMK.1 Ensembl:ENSG00000168393 euGenes: HUgn1841
    ECgene: DTYMK Kegg: 1841 H-InvDB: DTYMK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DTYMK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DTYMK gene:
    Search GeneIP for patents involving DTYMK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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