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DTYMK Gene

protein-coding   GIFtS: 67
GCID: GC02M242615

Deoxythymidylate Kinase (Thymidylate Kinase)

  Search for DTYMK
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deoxythymidylate Kinase (Thymidylate Kinase)1 2     Thymidylate (DTMP) Kinase1
DTMP Kinase1 2 3     PP37312
CDC82 3 5     Thymidylate Kinase2
TYMK2 3 5     EC 2.7.4.93
TMPK2 3     

External Ids:    HGNC: 30611   Entrez Gene: 18412   Ensembl: ENSG000001683937   OMIM: 1883455   UniProtKB: P239193   

Export aliases for DTYMK gene to outside databases

Previous GC identifers: GC02U990022 GC02P239574 GC02M242634 GC02M242935 GC02M242335 GC02M242263 GC02M234370


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DTYMK Gene:
DTYMK (deoxythymidylate kinase (thymidylate kinase)) is a protein-coding gene. GO annotations related to this gene include thymidylate kinase activity.

UniProtKB/Swiss-Prot: KTHY_HUMAN, P23919
Function: Catalyzes the conversion of dTMP to dTDP

Gene Wiki entry for DTYMK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DTYMK gene promoter:
         NF-1   NF-1/L   GATA-3   Nkx2-5   Ik-3   GATA-1   AREB6   c-Rel   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DTYMK promoter sequence
   Search Chromatin IP Primers for DTYMK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTYMK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37

DTYMK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTYMK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M242615:  view genomic region     (about GC identifiers)

Start:
242,615,157 bp from pter      End:
242,626,406 bp from pter
Size:
11,250 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KTHY_HUMAN, P23919 (See protein sequence)
Recommended Name: Thymidylate kinase  
Size: 212 amino acids; 23819 Da
Selected PDB 3D structures from and Proteopedia for DTYMK (see all 21):
1E2D (3D)        1E2E (3D)        1E2F (3D)        1E2G (3D)        1E2Q (3D)        1E98 (3D)    
Secondary accessions: Q6FGX1 Q9BUX4

Explore the universe of human proteins at neXtProt for DTYMK: NX_P23919

Explore proteomics data for DTYMK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys51
  • Modification sites at PhosphoSitePlus

  • See DTYMK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158503.1  NP_036277.2  

    ENSEMBL proteins: 
     ENSP00000304802   ENSP00000383581   ENSP00000408939   ENSP00000410647   ENSP00000387379  
    Reactome Protein details: P23919

    DTYMK Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DTYMK

     
    Search eBioscience for Proteins for DTYMK 

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    Search eBioscience for ELISAs for DTYMK 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR018094 Thymidylate_kinase
     IPR027417 P-loop_NTPase
     IPR018095 Thymidylate_kin_CS

    Graphical View of Domain Structure for InterPro Entry P23919

    ProtoNet protein and cluster: P23919

    1 Blocks protein domain: IPB000062 Thymidylate kinase

    UniProtKB/Swiss-Prot: KTHY_HUMAN, P23919
    Similarity: Belongs to the thymidylate kinase family


    Find genes that share domains with DTYMK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KTHY_HUMAN, P23919
    Function: Catalyzes the conversion of dTMP to dTDP
    Catalytic activity: ATP + dTMP = ADP + dTDP

         Genatlas biochemistry entry for DTYMK:
    deoxythymidylate kinase

         Enzyme Number (IUBMB): EC 2.7.4.91

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004798thymidylate kinase activity IDA8845311
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0050145nucleoside phosphate kinase activity EXP--
         
    Find genes that share ontologies with DTYMK           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DTYMK:
     Decreased telomerase activity  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DTYMK
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DTYMK

    miRNA
    Products:
        
    miRTarBase miRNAs that target DTYMK:
    hsa-mir-34a-5p (MIRT025515), hsa-mir-7-5p (MIRT025947), hsa-mir-183-5p (MIRT047109)

    Block miRNA regulation of human, mouse, rat DTYMK using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DTYMK
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    Inhib. RNA
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    Sino Biological Human cDNA Clone for DTYMK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTYMK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTYMK
    Addgene plasmids for DTYMK 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2
    chloroplast1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005759mitochondrial matrix IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with DTYMK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DTYMK About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    pyrimidine deoxyribonucleotides biosynthesis from CTP0.00
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    pyrimidine deoxyribonucleotide phosphorylation0.00
    pyrimidine deoxyribonucleotides de novo biosynthesis0.00
    3Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    Synthesis and interconversion of nucleotide di- and triphosphates0.00
    4Purine metabolism (KEGG)
    Pyrimidine metabolism0.38
    5Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics


    Find genes that share SuperPaths with DTYMK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for DTYMK
        superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    pyrimidine deoxyribonucleotide phosphorylation
    pyrimidine deoxyribonucleotides biosynthesis from CTP
    superpathway of pyrimidine deoxyribonucleoside salvage
    pyrimidine deoxyribonucleotides de novo biosynthesis


    1 Reactome Pathway for DTYMK
        Synthesis and interconversion of nucleotide di- and triphosphates

    1 PharmGKB Pathway for DTYMK
        Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    2 Kegg Pathways  (Kegg details for DTYMK):
        Pyrimidine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: KTHY_HUMAN, P23919
    Pathway: Pyrimidine metabolism; dTTP biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DTYMK
    Interactions:

        Search GeneGlobe Interaction Network for DTYMK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DTYMK (P239192, 3 ENSP000003048024) via UniProtKB, MINT, STRING, and/or I2D (see all 635)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL24P837312, 3MINT-7947479 I2D: score=1 
    SMARCA5O602642, 3MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7947479 I2D: score=1 
    CDK9P507502, 3, ENSP000003623614MINT-7947479 I2D: score=1 STRING: ENSP00000362361
    WRNIP1Q96S552, 3, ENSP000003701504MINT-7947479 I2D: score=1 STRING: ENSP00000370150
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006233dTDP biosynthetic process IEA--
    GO:0006235dTTP biosynthetic process IEA--
    GO:0007049cell cycle TAS8024690
    GO:0008283cell proliferation TAS8024690
    GO:0009165nucleotide biosynthetic process ----

    Find genes that share ontologies with DTYMK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DTYMK (KTHY)

    7 HMDB Compounds for DTYMK    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Thymidylic acid2'-Deoxythymidine 5'-monophosphate (see all 28)365-07-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Thymidine 3',5'-cyclic monophosphate3',5'-Cyclic TMP (see all 14)6453-60-7--
    dTDPDeoxy-tdp (see all 5)491-97-4--
    dUDP2'-deoxyuridine-5'-diphosphate (see all 3)4208-67-7--
    dUMP2'-Deoxy-5'-uridylate (see all 12)964-26-1--

    9 DrugBank Compounds for DTYMK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3'-Azido-3'-Deoxythymidine-5'-Monophosphate-- --target--17139284 17016423 10592235
    P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate-- --target--17139284 17016423 10592235
    Phosphoric Acid Mono-[3-Fluoro-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahyro-Furan-2-Ylmethyl] Ester-- --target--17139284 17016423 10592235
    Thymidine-5'-Phosphate2'-Deoxythymidine 5'-monophosphate (see all 36)365-07-1target--17139284 17016423 10592235
    2',3'-Dideoxythymidine-5'-Monophosphate-- --target--17139284 17016423
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate-- --target--17139284 17016423
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423
    Phosphoric Acid Mono-[3-Amino-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for DTYMK gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidylate 94.7 159 8024690 (7), 9826650 (4), 16461678 (4), 19749250 (4) (see all 77)
    aztmp 94.2 14 9826650 (3), 11071809 (2), 16248014 (1), 15134538 (1) (see all 8)
    aztdp 89.9 2 8941356 (1), 15722537 (1)
    nucleoside monophosphate 87.6 5 10873853 (1), 17999954 (1), 20065942 (1)
    triphosphate 82.7 4 11923581 (1), 15855530 (1), 20065942 (1)
    dttp 81.3 8 16103219 (3), 18523102 (1), 18413751 (1), 19296833 (1)
    zidovudine 75.6 35 11923581 (3), 18559937 (3), 9256287 (2), 11071809 (1) (see all 7)
    thymidine 74.1 31 9658118 (3), 11923581 (2), 11241312 (2), 2017365 (1) (see all 17)
    deoxycytidine 71.2 5 11275369 (1), 15748706 (1), 9658118 (1), 20516559 (1)
    nucleoside 69.1 3 16461678 (1), 17590962 (1), 19233899 (1)



    Find genes that share compounds with DTYMK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DTYMK gene (2 alternative transcripts): 
    NM_001165031.1  NM_012145.3  

    Unigene Cluster for DTYMK:

    Deoxythymidylate kinase (thymidylate kinase)
    Hs.471873  [show with all ESTs]
    Unigene Representative Sequence: AK022132
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305784(uc010zpa.2 uc002wbz.2 uc002wca.2 uc010zpb.2)
    ENST00000400770 ENST00000445261 ENST00000432348 ENST00000420144 ENST00000493095
    ENST00000464603
    miRNA
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    Clone
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    OriGene clones in human, mouse for DTYMK (see all 11)
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    GenScript: all cDNA clones in your preferred vector (see all 2): DTYMK (NM_012145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTYMK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTYMK
    Addgene plasmids for DTYMK 
    Primer
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    OriGene qPCR primer pairs and template standards for DTYMK
    OriGene qSTAR qPCR primer pairs in human, mouse for DTYMK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTYMK
      QuantiTect SYBR Green Assays in human, mouse, rat DTYMK
      QuantiFast Probe-based Assays in human, mouse, rat DTYMK

    Additional mRNA sequence: 

    AK022132.1 AK223434.1 BC001827.2 BC147006.1 BC147010.1 BC171894.1 BC171902.1 BC171903.1 
    CR541986.1 CR542015.1 NR_033255.1 X54729.1 

    18 DOTS entries:

    DT.75120001  DT.99954119  DT.97855060  DT.100028903  DT.92029550  DT.91758525  DT.86836386  DT.100641151 
    DT.100028902  DT.100764814  DT.100867068  DT.120958590  DT.95289177  DT.97766456  DT.97855061  DT.100867067 
    DT.102831795  DT.92033260 

    Selected AceView cDNA sequences (see all 293):

    BM674889 BX103646 BF939159 R05658 AK126180 CR542015 CR620414 CR599450 
    CR623128 CR593291 BM758825 BM552707 BQ229218 BU182335 CF528035 BM046159 
    CR604693 AA427389 BM717691 AI189369 AI096912 BU161701 AI095749 BM763180 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DTYMK (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:                                                  -     -     -     -                                       
    SP2:                                                  -     -     -     -           -                           
    SP3:                                                  -     -     -     -     -                                 
    SP4:                                            -     -     -     -     -     -                                 
    SP5:                                            -     -     -     -     -                                       


    ECgene alternative splicing isoforms for DTYMK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DTYMK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGAGCGA
    DTYMK Expression
    About this image


    DTYMK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    DTYMK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DTYMK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471873
        Custom PCR Arrays for DTYMK
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DTYMK
    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DTYMK gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtymk1 , 5 deoxythymidylate kinase1, 5 82.55(n)1
    81.13(a)1
      1 (47.34 cM)5
    219151  NM_001105667.11  NP_001099137.11 
     937925765 
    chicken
    (Gallus gallus)
    Aves DTYMK6
    Gallus gallus deoxythymidylate kinase (thymidylate...
    29(a)
    1 ↔ 1
    9(4282286-4287699)
    lizard
    (Anolis carolinensis)
    Reptilia DTYMK6
    deoxythymidylate kinase (thymidylate kinase)
    75(a)
    1 ↔ 1
    3(30562834-30571520)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193822 Xenopus laevis transcribed sequence with weak similarity more 72.54(n)    BX850634.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dtymk1 deoxythymidylate kinase (thymidylate kinase) 62.74(n)
    64.15(a)
      567734  NM_001037110.1  NP_001032187.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57571 , 3 thymidylate kinase3
    CG57571
    41(a)3
    49.68(n)1
    45.19(a)1
      55B43
    370621  NM_001274136.11  NP_001261065.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R53.21 , 3 thymidylate kinase3
    R53.21
    39(a)3
    47.29(n)1
    42.36(a)1
      II(9963073-9966991)3
    1745531  NM_063750.31  NP_496151.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC8(YJR057W)4
    CDC81
    Thymidylate and uridylate kinase, functions in de novo more4
    CDC81
    51.76(n)1
    52.8(a)1
      10(544062-544712)4
    8535201, 4  NP_012591.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ZEU11 ZEU1 50.9(n)
    51.23(a)
      836063  NM_180891.3  NP_851222.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06399001 Os07g0639900 53.78(n)
    54.67(a)
      4344056  NM_001066953.2  NP_001060418.2 


    ENSEMBL Gene Tree for DTYMK (if available)
    TreeFam Gene Tree for DTYMK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DTYMK gene
    11 SIMAP similar genes for DTYMK using alignment to 6 protein entries:     KTHY_HUMAN (see all proteins):
    LOC727761    LINC00596    FAM175A    AURA2    ZNF564    NF2
    UTY    FAM3A    SHANK2    SEPT2    ZNF74

    Find genes that share paralogs with DTYMK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DTYMK (see all 361)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850004391,2
    --242614677(+) GGCAAC/TATAGC 3 -- int10--------
    rs46759131,2
    C,F--242614709(-) CCTGGC/GTAATT 3 -- int12Minor allele frequency- G:0.33NA 6
    rs46759121,2
    C--242614718(-) TTCACC/TGTGCC 3 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs1463681731,2
    --242614750(+) AGGAGA/GCTGAA 3 -- int10--------
    rs1924462941,2
    --242614831(+) TGGGCA/GACAGT 3 -- int10--------
    rs1381720821,2
    --242615000(+) GGCTGC/TAACTG 3 -- int10--------
    rs1131427771,2
    C--242615033(+) CTCAAC/TTAGGC 3 -- int10--------
    rs1129320131,2
    F--242615148(+) TGAAGC/TGTTCC 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs781808291,2
    C,F--242615172(+) AGGTCT/GTTTTT 3 -- ut31 nc-transcript-variant3Minor allele frequency- G:0.33NA WA 6
    rs1838308481,2
    --242615175(+) TCGTTC/TTTTAC 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for DTYMK (242615157 - 242626406 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DTYMK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508901CNV Insertion20534489
    dgv4495n71CNV Loss21882294
    dgv4493n71CNV Loss21882294
    dgv4494n71CNV Loss21882294
    dgv4496n71CNV Loss21882294
    nsv876242CNV Loss21882294
    nsv876226CNV Loss21882294
    dgv4497n71CNV Loss21882294
    dgv165e55CNV Loss17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DTYMK
    DNA2.0 Custom Variant and Variant Library Synthesis for DTYMK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188345    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DTYMK:
    Smallpox

    Find genes that share disorders with DTYMK           About GenesLikeMe

    5 Novoseek inferred disease relationships for DTYMK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 52.3 23 17910427 (3), 12662932 (2), 12898625 (2), 15628853 (2) (see all 16)
    immunodeficiency 30.7 4 11923581 (1), 18559937 (1), 15722537 (1)
    herpes simplex 29.3 1 9281520 (1)
    infectious disease 23.4 1 16461678 (1)
    cancer 0 1 16461678 (1)


    Export disorders for DTYMK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DTYMK gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with DTYMK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. (PubMed id 8024690)1, 2, 3, 9 Huang S.H.... Jong A. (DNA Cell Biol. 1994)
    2. Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. (PubMed id 2017365)1, 2, 3, 9 Su J.Y. and Sclafani R.A. (Nucleic Acids Res. 1991)
    3. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. (PubMed id 12614151)1, 2, 9 Ostermann N.... Lavie A. (Biochemistry 2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. (PubMed id 18413751)1, 9 Hu C.M. and Chang Z.F. (Cancer Res. 2008)
    6. Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases. (PubMed id 11008000)1, 9 Van Rompay A.R....Karlsson A. (amp 2000)
    7. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1841 HGNC: 3061 AceView: DTYMK.1 Ensembl:ENSG00000168393 euGenes: HUgn1841
    ECgene: DTYMK Kegg: 1841 H-InvDB: DTYMK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DTYMK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DTYMK gene:
    Search GeneIP for patents involving DTYMK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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