Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DTYMK Gene

Aliases for DTYMK Gene

  • Deoxythymidylate Kinase 2 3 5
  • DTMP Kinase 2 3 4
  • Deoxythymidylate Kinase (Thymidylate Kinase) 2 3
  • CDC8 3 4
  • TMPK 3 4
  • TYMK 3 4
  • Thymidylate (DTMP) Kinase 2
  • Thymidylate Kinase 3
  • EC 2.7.4.9 4
  • PP3731 3

External Ids for DTYMK Gene

Previous GeneCards Identifiers for DTYMK Gene

  • GC02U990022
  • GC02P239574
  • GC02M242634
  • GC02M242935
  • GC02M242335
  • GC02M242263
  • GC02M234370
  • GC02M242615

Summaries for DTYMK Gene

GeneCards Summary for DTYMK Gene

DTYMK (Deoxythymidylate Kinase) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include kinase activity and thymidylate kinase activity.

UniProtKB/Swiss-Prot for DTYMK Gene

  • Catalyzes the conversion of dTMP to dTDP.

Gene Wiki entry for DTYMK Gene

Additional gene information for DTYMK Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTYMK Gene

Genomics for DTYMK Gene

Regulatory Elements for DTYMK Gene

Enhancers for DTYMK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H241543 1.3 Ensembl ENCODE 19.2 +140.8 140790 4 HDGF PKNOX1 ZNF133 ARID4B YBX1 ZNF2 ZNF121 ZNF766 FOS ZNF548 ENSG00000223374 MTERF4 ATG4B ANKMY1 ING5 CAPN10 FARP2 SNED1 D2HGDH DTYMK
GH02H241616 1.2 ENCODE dbSUPER 20 +68.0 67985 4 HDGF PKNOX1 GLI4 YY1 ETS1 ZNF143 FOS SP3 YY2 REST ENSG00000223374 ING5 SNED1 ENSG00000235351 MTERF4 FARP2 BOK D2HGDH DTYMK SEPT2
GH02H241313 1.4 ENCODE dbSUPER 10.5 +370.9 370938 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SEPT2 ANKMY1 FARP2 MTERF4 HDLBP ING5 ATG4B ENSG00000235351 ANO7 ENSG00000223374
GH02H241733 1 ENCODE 10.5 -48.0 -48020 2 HDGF ATF1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF121 GLIS2 ZNF143 D2HGDH ENSG00000223374 ENSG00000235351 SNED1 FARP2 DTYMK ING5 GAL3ST2 PIR35530 GC02P241738
GH02H241664 1.1 Ensembl ENCODE 9.5 +21.3 21276 2 PKNOX1 ARID4B SIN3A RAD21 ZEB1 GLIS2 ZNF366 SCRT2 FOS EGR2 ING5 ATG4B D2HGDH ENSG00000234793 DTYMK GC02M241661
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DTYMK on UCSC Golden Path with GeneCards custom track

Promoters for DTYMK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133313 -109 2201 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for DTYMK Gene

Chromosome:
2
Start:
241,675,742 bp from pter
End:
241,686,991 bp from pter
Size:
11,250 bases
Orientation:
Minus strand

Genomic View for DTYMK Gene

Genes around DTYMK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTYMK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTYMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTYMK Gene

Proteins for DTYMK Gene

  • Protein details for DTYMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23919-KTHY_HUMAN
    Recommended name:
    Thymidylate kinase
    Protein Accession:
    P23919
    Secondary Accessions:
    • B7ZW70
    • Q6FGX1
    • Q9BUX4

    Protein attributes for DTYMK Gene

    Size:
    212 amino acids
    Molecular mass:
    23819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DTYMK Gene

    Alternative splice isoforms for DTYMK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTYMK Gene

Post-translational modifications for DTYMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for DTYMK
  • Santa Cruz Biotechnology (SCBT) Antibodies for DTYMK

No data available for DME Specific Peptides for DTYMK Gene

Domains & Families for DTYMK Gene

Gene Families for DTYMK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DTYMK Gene

Suggested Antigen Peptide Sequences for DTYMK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23919

UniProtKB/Swiss-Prot:

KTHY_HUMAN :
  • Belongs to the thymidylate kinase family.
Family:
  • Belongs to the thymidylate kinase family.
genes like me logo Genes that share domains with DTYMK: view

Function for DTYMK Gene

Molecular function for DTYMK Gene

GENATLAS Biochemistry:
deoxythymidylate kinase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + dTMP = ADP + dTDP.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of dTMP to dTDP.

Enzyme Numbers (IUBMB) for DTYMK Gene

Phenotypes From GWAS Catalog for DTYMK Gene

Gene Ontology (GO) - Molecular Function for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004798 thymidylate kinase activity IEA,IDA 8845311
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity IBA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DTYMK: view
genes like me logo Genes that share phenotypes with DTYMK: view

Animal Model Products

CRISPR Products

miRNA for DTYMK Gene

miRTarBase miRNAs that target DTYMK

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DTYMK
  • Applied Biological Materials Clones for DTYMK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTYMK Gene

Localization for DTYMK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTYMK gene
Compartment Confidence
cytosol 5
mitochondrion 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005759 mitochondrial matrix IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DTYMK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DTYMK Gene

Pathways & Interactions for DTYMK Gene

genes like me logo Genes that share pathways with DTYMK: view

UniProtKB/Swiss-Prot P23919-KTHY_HUMAN

  • Pathway: Pyrimidine metabolism; dTTP biosynthesis.

Gene Ontology (GO) - Biological Process for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006227 dUDP biosynthetic process IBA --
GO:0006233 dTDP biosynthetic process IBA,IEA --
GO:0006235 dTTP biosynthetic process IBA,IEA --
GO:0007049 cell cycle TAS 8024690
GO:0008283 cell proliferation TAS 8024690
genes like me logo Genes that share ontologies with DTYMK: view

No data available for SIGNOR curated interactions for DTYMK Gene

Drugs & Compounds for DTYMK Gene

(14) Drugs for DTYMK Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
5-Thymidylic acid Experimental Pharma Target 0
2',3'-Dideoxythymidine-5'-Monophosphate Experimental Pharma Target 0
3'-Azido-3'-Deoxythymidine-5'-Monophosphate Experimental Pharma Target 0
P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate Experimental Pharma Target 0
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate Experimental Pharma Target 0

(20) Additional Compounds for DTYMK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
dudp
  • 2'-Deoxyuridine-5'-diphosphate
  • Deoxyuridine-diphosphate
  • dUDP
4208-67-7
dUMP
  • 2'-Deoxy-5'-uridylate
  • 2'-Deoxy-5'-uridylic acid
  • 2'-Deoxyuridine 5'-monophosphate
  • 2'-Deoxyuridine 5'-phosphate
  • 2'-Deoxyuridylate
964-26-1
Thymidine 3',5'-cyclic monophosphate
  • 3',5'-Cyclic thymidine monophosphate
  • 3',5'-Cyclic TMP
  • 4H-Furo[3,2-D]-1,3,2-dioxaphosphorin thymidine deriv.
  • cTMP
  • Cyclic 3',5'-dTMP
6453-60-7
genes like me logo Genes that share compounds with DTYMK: view

Transcripts for DTYMK Gene

Unigene Clusters for DTYMK Gene

Deoxythymidylate kinase (thymidylate kinase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DTYMK
  • Applied Biological Materials Clones for DTYMK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DTYMK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for DTYMK Gene

GeneLoc Exon Structure for
DTYMK
ECgene alternative splicing isoforms for
DTYMK

Expression for DTYMK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTYMK Gene

Protein differential expression in normal tissues from HIPED for DTYMK Gene

This gene is overexpressed in Bone (14.2) and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DTYMK Gene



Protein tissue co-expression partners for DTYMK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DTYMK Gene:

DTYMK

SOURCE GeneReport for Unigene cluster for DTYMK Gene:

Hs.471873

Evidence on tissue expression from TISSUES for DTYMK Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with DTYMK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTYMK Gene

Orthologs for DTYMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTYMK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTYMK 33 34
  • 99.84 (n)
mouse
(Mus musculus)
Mammalia Dtymk 33 16 34
  • 82.55 (n)
rat
(Rattus norvegicus)
Mammalia Dtymk 33
  • 82.23 (n)
cow
(Bos Taurus)
Mammalia DTYMK 33 34
  • 82.15 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 80 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DTYMK 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTYMK 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTYMK 34
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTYMK 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtymk 33
  • 64.94 (n)
Str.7637 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19382 33
zebrafish
(Danio rerio)
Actinopterygii dtymk 33 34
  • 62.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005260 33
  • 54.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5757 35 33 34
  • 49.68 (n)
worm
(Caenorhabditis elegans)
Secernentea R53.2 35 33 34
  • 47.29 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR369W 33
  • 52.9 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC8 33 34 36
  • 51.76 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06556g 33
  • 50.6 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ZEU1 33
  • 50.9 (n)
rice
(Oryza sativa)
Liliopsida Os07g0639900 33
  • 53.78 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07773 33
  • 52.92 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tmp1 33
  • 52.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToOne
Species where no ortholog for DTYMK was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTYMK Gene

ENSEMBL:
Gene Tree for DTYMK (if available)
TreeFam:
Gene Tree for DTYMK (if available)

Paralogs for DTYMK Gene

(11) SIMAP similar genes for DTYMK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DTYMK: view

No data available for Paralogs for DTYMK Gene

Variants for DTYMK Gene

Sequence variations from dbSNP and Humsavar for DTYMK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000242398 -- 241,688,233(+) CACTC(C/T)TACCT intron-variant, upstream-variant-2KB
rs1000405985 -- 241,677,678(+) GCCTG(C/T)GAGTC intron-variant
rs1000472141 -- 241,686,872(+) AGCTA(A/G)TATTT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000588761 -- 241,682,832(+) GGCAG(A/G)AGAAT intron-variant, reference, missense
rs1000672993 -- 241,682,166(+) GAGAC(C/T)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTYMK Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
nsv508901 CNV insertion 20534489
nsv584974 CNV gain 21841781

Variation tolerance for DTYMK Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTYMK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTYMK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTYMK Gene

Disorders for DTYMK Gene

Relevant External Links for DTYMK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTYMK

No disorders were found for DTYMK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTYMK Gene

Publications for DTYMK Gene

  1. Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. (PMID: 8024690) Huang SH … Jong A (DNA and cell biology 1994) 2 3 4 22 60
  2. Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. (PMID: 2017365) Su JY … Sclafani RA (Nucleic acids research 1991) 2 3 4 22 60
  3. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. (PMID: 12614151) Ostermann N … Lavie A (Biochemistry 2003) 3 4 22 60
  4. Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. (PMID: 18413751) Hu CM … Chang ZF (Cancer research 2008) 3 22 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for DTYMK Gene

  • Addgene plasmids for DTYMK

Sources for DTYMK Gene

Content
Loading form....