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Aliases for DTYMK Gene

Aliases for DTYMK Gene

  • Deoxythymidylate Kinase (Thymidylate Kinase) 2 3
  • DTMP Kinase 2 3 4
  • CDC8 3 4 6
  • TYMK 3 4 6
  • TMPK 3 4
  • Thymidylate (DTMP) Kinase 2
  • Thymidylate Kinase 3
  • EC 2.7.4.9 4
  • PP3731 3

External Ids for DTYMK Gene

Summaries for DTYMK Gene

GeneCards Summary for DTYMK Gene

DTYMK (Deoxythymidylate Kinase (Thymidylate Kinase)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include thymidylate kinase activity.

UniProtKB/Swiss-Prot for DTYMK Gene

  • Catalyzes the conversion of dTMP to dTDP

Gene Wiki entry for DTYMK Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTYMK Gene

Genomics for DTYMK Gene

Genomic Location for DTYMK Gene

Start:
241,675,742 bp from pter
End:
241,686,991 bp from pter
Size:
11,250 bases
Orientation:
Minus strand

Genomic View for DTYMK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTYMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTYMK Gene

Regulatory Elements for DTYMK Gene

Proteins for DTYMK Gene

  • Protein details for DTYMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23919-KTHY_HUMAN
    Recommended name:
    Thymidylate kinase
    Protein Accession:
    P23919
    Secondary Accessions:
    • B7ZW70
    • Q6FGX1
    • Q9BUX4

    Protein attributes for DTYMK Gene

    Size:
    212 amino acids
    Molecular mass:
    23819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DTYMK Gene

    Alternative splice isoforms for DTYMK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTYMK Gene

Proteomics data for DTYMK Gene at MOPED

Post-translational modifications for DTYMK Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys51

Other Protein References for DTYMK Gene

No data available for DME Specific Peptides for DTYMK Gene

Domains for DTYMK Gene

Protein Domains for DTYMK Gene

UniProtKB/Swiss-Prot:

KTHY_HUMAN
Family:
  • Belongs to the thymidylate kinase family.:
    • P23919
genes like me logo Genes that share domains with DTYMK: view

No data available for Gene Families for DTYMK Gene

Function for DTYMK Gene

Molecular function for DTYMK Gene

GENATLAS Biochemistry: deoxythymidylate kinase
UniProtKB/Swiss-Prot CatalyticActivity: ATP + dTMP = ADP + dTDP
UniProtKB/Swiss-Prot Function: Catalyzes the conversion of dTMP to dTDP

Enzyme Numbers (IUBMB) for DTYMK Gene

Gene Ontology (GO) - Molecular Function for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004798 thymidylate kinase activity IDA 8845311
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity IBA --
GO:0016301 kinase activity --
GO:0050145 nucleoside phosphate kinase activity EXP --
genes like me logo Genes that share ontologies with DTYMK: view

Phenotypes for DTYMK Gene

genes like me logo Genes that share phenotypes with DTYMK: view

miRNA for DTYMK Gene

miRTarBase miRNAs that target DTYMK

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DTYMK Gene

Localization for DTYMK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTYMK Gene COMPARTMENTS Subcellular localization image for DTYMK gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005739 mitochondrion IBA --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005759 mitochondrial matrix IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DTYMK: view

Pathways for DTYMK Gene

genes like me logo Genes that share pathways with DTYMK: view

UniProtKB/Swiss-Prot P23919-KTHY_HUMAN

  • Pathway: Pyrimidine metabolism; dTTP biosynthesis

Gene Ontology (GO) - Biological Process for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006227 dUDP biosynthetic process IBA --
GO:0006233 dTDP biosynthetic process IBA --
GO:0006235 dTTP biosynthetic process IEA --
GO:0007049 cell cycle TAS 8024690
GO:0008283 cell proliferation TAS 8024690
genes like me logo Genes that share ontologies with DTYMK: view

Compounds for DTYMK Gene

(7) HMDB Compounds for DTYMK Gene

Compound Synonyms Cas Number PubMed IDs
5-Thymidylic acid
  • 2'-Deoxythymidine 5'-monophosphate
365-07-1
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
dTDP
  • Deoxy-tdp
491-97-4
dUDP
  • 2'-deoxyuridine-5'-diphosphate
4208-67-7

(22) Novoseek inferred chemical compound relationships for DTYMK Gene

Compound -log(P) Hits PubMed IDs
thymidylate 94.7 122
aztmp 94.2 11
aztdp 89.9 2
nucleoside monophosphate 87.6 3
triphosphate 82.7 3
genes like me logo Genes that share compounds with DTYMK: view

Transcripts for DTYMK Gene

Unigene Clusters for DTYMK Gene

Deoxythymidylate kinase (thymidylate kinase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTYMK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for DTYMK Gene

GeneLoc Exon Structure for
DTYMK
ECgene alternative splicing isoforms for
DTYMK

Expression for DTYMK Gene

mRNA expression in normal human tissues for DTYMK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DTYMK Gene

SOURCE GeneReport for Unigene cluster for DTYMK Gene Hs.471873

genes like me logo Genes that share expressions with DTYMK: view

Orthologs for DTYMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTYMK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTYMK 36
  • 99.84 (n)
  • 100 (a)
DTYMK 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DTYMK 36
  • 82.15 (n)
  • 82.94 (a)
DTYMK 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DTYMK 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtymk 36
  • 82.55 (n)
  • 81.13 (a)
Dtymk 16
Dtymk 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DTYMK 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtymk 36
  • 82.23 (n)
  • 81.13 (a)
chicken
(Gallus gallus)
Aves DTYMK 37
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTYMK 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19382 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dtymk 36
  • 64.94 (n)
  • 65.57 (a)
Str.7637 36
zebrafish
(Danio rerio)
Actinopterygii dtymk 36
  • 62.74 (n)
  • 64.15 (a)
dtymk 37
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005260 36
  • 54.84 (n)
  • 46.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5757 36
  • 49.68 (n)
  • 45.19 (a)
CG5757 37
  • 45 (a)
OneToOne
CG5757 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea R53.2 36
  • 47.29 (n)
  • 42.36 (a)
R53.2 37
  • 38 (a)
OneToOne
R53.2 38
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR369W 36
  • 52.9 (n)
  • 45.65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC8 36
  • 51.76 (n)
  • 52.8 (a)
CDC8 37
  • 44 (a)
OneToOne
CDC8 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06556g 36
  • 50.6 (n)
  • 47.18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ZEU1 36
  • 50.9 (n)
  • 51.23 (a)
rice
(Oryza sativa)
Liliopsida Os07g0639900 36
  • 53.78 (n)
  • 54.67 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07773 36
  • 52.92 (n)
  • 50.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tmp1 36
  • 52.33 (n)
  • 50.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToOne
Species with no ortholog for DTYMK:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTYMK Gene

ENSEMBL:
Gene Tree for DTYMK (if available)
TreeFam:
Gene Tree for DTYMK (if available)

Paralogs for DTYMK Gene

Selected SIMAP similar genes for DTYMK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DTYMK: view

No data available for Paralogs for DTYMK Gene

Variants for DTYMK Gene

Sequence variations from dbSNP and Humsavar for DTYMK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs5860 -- 241,676,047(+) GACTC(C/T)GCTGG utr-variant-3-prime, nc-transcript-variant
rs1131195 -- 241,678,635(-) CTAGA(C/T)TGGTG intron-variant, synonymous-codon, reference, nc-transcript-variant
rs1131266 -- 241,675,983(-) CTCTT(C/T)TGCCC utr-variant-3-prime, nc-transcript-variant
rs1803265 -- 241,676,066(-) CTCGC(A/G)GAAGG utr-variant-3-prime, nc-transcript-variant
rs1803266 -- 241,678,599(-) AAACC(C/T)GACCT intron-variant, reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DTYMK Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
dgv4493n71 CNV Loss 21882294
dgv4494n71 CNV Loss 21882294
dgv4495n71 CNV Loss 21882294
dgv165e55 CNV Loss 17911159
dgv4496n71 CNV Loss 21882294
nsv508901 CNV Insertion 20534489
nsv876242 CNV Loss 21882294
dgv4497n71 CNV Loss 21882294

Relevant External Links for DTYMK Gene

HapMap Linkage Disequilibrium report
DTYMK

Disorders for DTYMK Gene

(1) University of Copenhagen DISEASES for DTYMK Gene

(5) Novoseek inferred disease relationships for DTYMK Gene

Disease -log(P) Hits PubMed IDs
tuberculosis 52.3 22
immunodeficiency 30.7 3
herpes simplex 29.3 1
infectious disease 23.4 1
cancer 0 1
genes like me logo Genes that share disorders with DTYMK: view

No data available for UniProtKB/Swiss-Prot for DTYMK Gene

Publications for DTYMK Gene

  1. Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. (PMID: 8024690) Huang S.H. … Jong A. (DNA Cell Biol. 1994) 2 3 4 23
  2. Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. (PMID: 2017365) Su J.Y. … Sclafani R.A. (Nucleic Acids Res. 1991) 2 3 4 23
  3. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. (PMID: 12614151) Ostermann N. … Lavie A. (Biochemistry 2003) 3 4 23
  4. Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. (PMID: 18413751) Hu C.M. … Chang Z.F. (Cancer Res. 2008) 3 23
  5. Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases. (PMID: 11008000) Van Rompay A.R. … Karlsson A. (Pharmacol. Ther. 2000) 3 23

Products for DTYMK Gene

  • Addgene plasmids for DTYMK

Sources for DTYMK Gene

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