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Aliases for DTYMK Gene

Aliases for DTYMK Gene

  • Deoxythymidylate Kinase 2 3 5
  • DTMP Kinase 2 3 4
  • Deoxythymidylate Kinase (Thymidylate Kinase) 2 3
  • CDC8 3 4
  • TMPK 3 4
  • TYMK 3 4
  • Thymidylate (DTMP) Kinase 2
  • EC 2.7.4.9 4
  • PP3731 3

External Ids for DTYMK Gene

Previous GeneCards Identifiers for DTYMK Gene

  • GC02U990022
  • GC02P239574
  • GC02M242634
  • GC02M242935
  • GC02M242335
  • GC02M242263
  • GC02M234370
  • GC02M242615

Summaries for DTYMK Gene

GeneCards Summary for DTYMK Gene

DTYMK (Deoxythymidylate Kinase) is a Protein Coding gene. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include kinase activity and thymidylate kinase activity.

UniProtKB/Swiss-Prot for DTYMK Gene

  • Catalyzes the conversion of dTMP to dTDP.

Gene Wiki entry for DTYMK Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTYMK Gene

Genomics for DTYMK Gene

Regulatory Elements for DTYMK Gene

Enhancers for DTYMK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DTYMK on UCSC Golden Path with GeneCards custom track

Promoters for DTYMK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DTYMK on UCSC Golden Path with GeneCards custom track

Genomic Location for DTYMK Gene

Chromosome:
2
Start:
241,675,742 bp from pter
End:
241,686,991 bp from pter
Size:
11,250 bases
Orientation:
Minus strand

Genomic View for DTYMK Gene

Genes around DTYMK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTYMK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTYMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTYMK Gene

Proteins for DTYMK Gene

  • Protein details for DTYMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23919-KTHY_HUMAN
    Recommended name:
    Thymidylate kinase
    Protein Accession:
    P23919
    Secondary Accessions:
    • B7ZW70
    • Q6FGX1
    • Q9BUX4

    Protein attributes for DTYMK Gene

    Size:
    212 amino acids
    Molecular mass:
    23819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DTYMK Gene

    Alternative splice isoforms for DTYMK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTYMK Gene

Proteomics data for DTYMK Gene at MOPED

Post-translational modifications for DTYMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DTYMK Gene

Domains & Families for DTYMK Gene

Protein Domains for DTYMK Gene

Suggested Antigen Peptide Sequences for DTYMK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23919

UniProtKB/Swiss-Prot:

KTHY_HUMAN :
  • Belongs to the thymidylate kinase family.
Family:
  • Belongs to the thymidylate kinase family.
genes like me logo Genes that share domains with DTYMK: view

No data available for Gene Families for DTYMK Gene

Function for DTYMK Gene

Molecular function for DTYMK Gene

GENATLAS Biochemistry:
deoxythymidylate kinase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + dTMP = ADP + dTDP.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of dTMP to dTDP.

Enzyme Numbers (IUBMB) for DTYMK Gene

Gene Ontology (GO) - Molecular Function for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009041 uridylate kinase activity IBA --
genes like me logo Genes that share ontologies with DTYMK: view
genes like me logo Genes that share phenotypes with DTYMK: view

Animal Model Products

miRNA for DTYMK Gene

miRTarBase miRNAs that target DTYMK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTYMK Gene

Localization for DTYMK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTYMK Gene COMPARTMENTS Subcellular localization image for DTYMK gene
Compartment Confidence
cytosol 5
mitochondrion 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IBA --
genes like me logo Genes that share ontologies with DTYMK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DTYMK Gene

Pathways & Interactions for DTYMK Gene

genes like me logo Genes that share pathways with DTYMK: view

UniProtKB/Swiss-Prot P23919-KTHY_HUMAN

  • Pathway: Pyrimidine metabolism; dTTP biosynthesis.

Gene Ontology (GO) - Biological Process for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006227 dUDP biosynthetic process IBA --
GO:0006233 dTDP biosynthetic process IEA,IBA --
GO:0006235 dTTP biosynthetic process IEA --
GO:0045445 myoblast differentiation IEA --
GO:0046686 response to cadmium ion IEA --
genes like me logo Genes that share ontologies with DTYMK: view

No data available for SIGNOR curated interactions for DTYMK Gene

Drugs & Compounds for DTYMK Gene

(17) Drugs for DTYMK Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
5-Thymidylic acid Experimental Pharma Target 0
2',3'-Dideoxythymidine-5'-Monophosphate Experimental Pharma Target 0
3'-Azido-3'-Deoxythymidine-5'-Monophosphate Experimental Pharma Target 0
P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate Experimental Pharma Target 0

(18) Additional Compounds for DTYMK Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
dudp
  • 2'-Deoxyuridine-5'-diphosphate
  • Deoxyuridine-diphosphate
  • dUDP
4208-67-7
Thymidine 3',5'-cyclic monophosphate
  • 3',5'-Cyclic thymidine monophosphate
  • 3',5'-Cyclic TMP
  • 4H-Furo[3,2-D]-1,3,2-dioxaphosphorin thymidine deriv.
  • cTMP
  • Cyclic 3',5'-dTMP
6453-60-7
genes like me logo Genes that share compounds with DTYMK: view

Transcripts for DTYMK Gene

Unigene Clusters for DTYMK Gene

Deoxythymidylate kinase (thymidylate kinase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTYMK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for DTYMK Gene

GeneLoc Exon Structure for
DTYMK
ECgene alternative splicing isoforms for
DTYMK

Expression for DTYMK Gene

mRNA expression in normal human tissues for DTYMK Gene

Protein differential expression in normal tissues from HIPED for DTYMK Gene

This gene is overexpressed in Bone (14.2) and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DTYMK Gene



SOURCE GeneReport for Unigene cluster for DTYMK Gene Hs.471873

genes like me logo Genes that share expression patterns with DTYMK: view

Protein tissue co-expression partners for DTYMK Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DTYMK Gene

Orthologs for DTYMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTYMK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DTYMK 35
  • 82.15 (n)
  • 82.94 (a)
DTYMK 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtymk 35
  • 82.55 (n)
  • 81.13 (a)
Dtymk 16
Dtymk 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DTYMK 35
  • 99.84 (n)
  • 100 (a)
DTYMK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtymk 35
  • 82.23 (n)
  • 81.13 (a)
dog
(Canis familiaris)
Mammalia DTYMK 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DTYMK 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTYMK 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTYMK 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtymk 35
  • 64.94 (n)
  • 65.57 (a)
Str.7637 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19382 35
zebrafish
(Danio rerio)
Actinopterygii dtymk 35
  • 62.74 (n)
  • 64.15 (a)
dtymk 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5757 37
  • 41 (a)
CG5757 35
  • 49.68 (n)
  • 45.19 (a)
CG5757 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005260 35
  • 54.84 (n)
  • 46.8 (a)
worm
(Caenorhabditis elegans)
Secernentea R53.2 37
  • 39 (a)
R53.2 35
  • 47.29 (n)
  • 42.36 (a)
R53.2 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR369W 35
  • 52.9 (n)
  • 45.65 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06556g 35
  • 50.6 (n)
  • 47.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC8 35
  • 51.76 (n)
  • 52.8 (a)
CDC8 36
  • 44 (a)
OneToOne
CDC8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ZEU1 35
  • 50.9 (n)
  • 51.23 (a)
rice
(Oryza sativa)
Liliopsida Os07g0639900 35
  • 53.78 (n)
  • 54.67 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07773 35
  • 52.92 (n)
  • 50.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tmp1 35
  • 52.33 (n)
  • 50.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for DTYMK:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTYMK Gene

ENSEMBL:
Gene Tree for DTYMK (if available)
TreeFam:
Gene Tree for DTYMK (if available)

Paralogs for DTYMK Gene

(11) SIMAP similar genes for DTYMK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DTYMK: view

No data available for Paralogs for DTYMK Gene

Variants for DTYMK Gene

Sequence variations from dbSNP and Humsavar for DTYMK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1803265 -- 241,676,066(-) CTCGC(A/G)GAAGG nc-transcript-variant, utr-variant-3-prime
rs1803266 -- 241,678,599(-) AAACC(C/T)GACCT intron-variant, nc-transcript-variant, reference, synonymous-codon
rs1803267 -- 241,678,561(-) GGATG(A/C)TGCCA nc-transcript-variant, reference, missense
rs3209844 -- 241,676,057(-) GGCCC(C/T)GTCCC nc-transcript-variant, utr-variant-3-prime
rs1131195 -- 241,678,635(-) CTAGA(C/T)TGGTG intron-variant, nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DTYMK Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
dgv4493n71 CNV Loss 21882294
dgv4494n71 CNV Loss 21882294
dgv4495n71 CNV Loss 21882294
dgv165e55 CNV Loss 17911159
dgv4496n71 CNV Loss 21882294
nsv508901 CNV Insertion 20534489
nsv876242 CNV Loss 21882294
dgv4497n71 CNV Loss 21882294

Variation tolerance for DTYMK Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTYMK Gene

HapMap Linkage Disequilibrium report
DTYMK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTYMK Gene

Disorders for DTYMK Gene

Relevant External Links for DTYMK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTYMK

No disorders were found for DTYMK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTYMK Gene

Publications for DTYMK Gene

  1. Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. (PMID: 8024690) Huang S.H. … Jong A. (DNA Cell Biol. 1994) 2 3 4 23 67
  2. Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. (PMID: 2017365) Su J.Y. … Sclafani R.A. (Nucleic Acids Res. 1991) 2 3 23
  3. Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. (PMID: 18413751) Hu C.M. … Chang Z.F. (Cancer Res. 2008) 3 23
  4. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. (PMID: 12614151) Ostermann N. … Lavie A. (Biochemistry 2003) 3 23
  5. Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases. (PMID: 11008000) Van Rompay A.R. … Karlsson A. (Pharmacol. Ther. 2000) 3 23

Products for DTYMK Gene

Sources for DTYMK Gene

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