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Aliases for DTX4 Gene

Aliases for DTX4 Gene

  • Deltex 4, E3 Ubiquitin Ligase 2 3
  • RING Finger Protein 155 3 4
  • Protein Deltex-4 3 4
  • Deltex4 3 4
  • RNF155 3 4
  • E3 Ubiquitin-Protein Ligase DTX4 3
  • Deltex 4 Homolog (Drosophila) 2
  • Deltex Homolog 4 (Drosophila) 2
  • Deltex 4 Homolog 3
  • Deltex Homolog 4 3
  • EC 6.3.2.- 4
  • KIAA0937 4

External Ids for DTX4 Gene

Previous GeneCards Identifiers for DTX4 Gene

  • GC11P058715
  • GC11P058695
  • GC11P058939
  • GC11P055285

Summaries for DTX4 Gene

GeneCards Summary for DTX4 Gene

DTX4 (Deltex 4, E3 Ubiquitin Ligase) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ligase activity. An important paralog of this gene is DTX2.

UniProtKB/Swiss-Prot for DTX4 Gene

  • Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating Lys48-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX4 Gene

Genomics for DTX4 Gene

Regulatory Elements for DTX4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DTX4 Gene

Start:
59,171,430 bp from pter
End:
59,208,587 bp from pter
Size:
37,158 bases
Orientation:
Plus strand

Genomic View for DTX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX4 Gene

Proteins for DTX4 Gene

  • Protein details for DTX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2E6-DTX4_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase DTX4
    Protein Accession:
    Q9Y2E6
    Secondary Accessions:
    • Q0VF38

    Protein attributes for DTX4 Gene

    Size:
    619 amino acids
    Molecular mass:
    67258 Da
    Quaternary structure:
    • Interacts with NLRP4.
    SequenceCaution:
    • Sequence=BAA76781.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DTX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX4 Gene

Proteomics data for DTX4 Gene at MOPED

Post-translational modifications for DTX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTX4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DTX4 Gene

Domains for DTX4 Gene

Gene Families for DTX4 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for DTX4 Gene

Suggested Antigen Peptide Sequences for DTX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2E6

UniProtKB/Swiss-Prot:

DTX4_HUMAN :
  • Q9Y2E6
Domain:
  • The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • Contains 2 WWE domains.
Family:
  • Belongs to the Deltex family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with DTX4: view

Function for DTX4 Gene

Molecular function for DTX4 Gene

UniProtKB/Swiss-Prot Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating Lys48-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.

Enzyme Numbers (IUBMB) for DTX4 Gene

Gene Ontology (GO) - Molecular Function for DTX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with DTX4: view
genes like me logo Genes that share phenotypes with DTX4: view

Animal Model Products

miRNA for DTX4 Gene

miRTarBase miRNAs that target DTX4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DTX4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DTX4 Gene

Localization for DTX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTX4 Gene COMPARTMENTS Subcellular localization image for DTX4 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DTX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DTX4: view

Pathways for DTX4 Gene

genes like me logo Genes that share pathways with DTX4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9Y2E6-DTX4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DTX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
GO:0032479 regulation of type I interferon production TAS --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with DTX4: view

Transcripts for DTX4 Gene

Unigene Clusters for DTX4 Gene

Deltex homolog 4 (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DTX4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DTX4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTX4 Gene

No ASD Table

Relevant External Links for DTX4 Gene

GeneLoc Exon Structure for
DTX4
ECgene alternative splicing isoforms for
DTX4

Expression for DTX4 Gene

mRNA expression in normal human tissues for DTX4 Gene

mRNA differential expression in normal tissues according to GTEx for DTX4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DTX4 Gene

SOURCE GeneReport for Unigene cluster for DTX4 Gene Hs.523696

genes like me logo Genes that share expressions with DTX4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DTX4 Gene

Orthologs for DTX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTX4 35
  • 99.84 (n)
  • 99.68 (a)
DTX4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DTX4 35
  • 87.9 (n)
  • 92.47 (a)
DTX4 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DTX4 35
  • 88.93 (n)
  • 92.84 (a)
DTX4 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtx4 35
  • 87.72 (n)
  • 94.32 (a)
Dtx4 16
Dtx4 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DTX4 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTX4 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtx4 35
  • 88.44 (n)
  • 94.69 (a)
chicken
(Gallus gallus)
Aves DTX4 35
  • 76.99 (n)
  • 81.6 (a)
DTX4 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTX4 36
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dtx1 35
  • 68.19 (n)
  • 73.05 (a)
DTX4 (1 of 2) 36
  • 61 (a)
OneToMany
DTX4 (2 of 2) 36
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dx 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7641 36
  • 29 (a)
OneToMany
Species with no ortholog for DTX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX4 Gene

ENSEMBL:
Gene Tree for DTX4 (if available)
TreeFam:
Gene Tree for DTX4 (if available)

Paralogs for DTX4 Gene

Paralogs for DTX4 Gene

Selected SIMAP similar genes for DTX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DTX4: view

Variants for DTX4 Gene

Sequence variations from dbSNP and Humsavar for DTX4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs13173 -- 59,207,531(+) GGGGA(A/G)CATTC utr-variant-3-prime
rs491558 -- 59,187,058(-) TAAGG(A/G)AGGTT intron-variant
rs492660 -- 59,176,101(-) CACTT(C/T)TCACC intron-variant
rs498211 -- 59,175,508(-) TCTAG(G/T)CAGTC intron-variant
rs519287 -- 59,178,390(-) AGGCA(C/G)AACGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTX4 Gene

Variant ID Type Subtype PubMed ID
dgv386e1 CNV Complex 17122850

Relevant External Links for DTX4 Gene

HapMap Linkage Disequilibrium report
DTX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX4 Gene

Disorders for DTX4 Gene

No disorders were found for DTX4 Gene.

No data available for UniProtKB/Swiss-Prot for DTX4 Gene

Publications for DTX4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. (PMID: 22388039) Cui J. … Wang R.F. (Nat. Immunol. 2012) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Normal immune system development in mice lacking the Deltex-1 RING finger domain. (PMID: 15684394) Storck S. … Reynaud C.-A. (Mol. Cell. Biol. 2005) 3 4
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3

Products for DTX4 Gene

Sources for DTX4 Gene

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