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DTX4 Gene

protein-coding   GIFtS: 50
GCID: GC11P058939

Deltex 4, E3 Ubiquitin Ligase

(Previous names: deltex 4 homolog (Drosophila), deltex homolog 4 (Drosophila))
  Search for DTX4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deltex 4, E3 Ubiquitin Ligase1 2     Deltex Homolog 42
Protein Deltex-42 3     deltex42
RNF1552 3     E3 Ubiquitin-Protein Ligase DTX42
RING Finger Protein 1552 3     Deltex43
Deltex 4 Homolog (Drosophila)1     EC 6.3.2.-3
Deltex Homolog 4 (Drosophila)1     KIAA09373
Deltex 4 Homolog2     

External Ids:    HGNC: 291511   Entrez Gene: 232202   Ensembl: ENSG000001100427   UniProtKB: Q9Y2E63   

Export aliases for DTX4 gene to outside databases

Previous GC identifers: GC11P058715 GC11P058695 GC11P055285


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DTX4 Gene:
DTX4 (deltex 4, E3 ubiquitin ligase) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is DTX1.

UniProtKB/Swiss-Prot: DTX4_HUMAN, Q9Y2E6
Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a
broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo,
mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires
interaction with NLRP4




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DTX4 gene promoter:
         Pax-5   NRSF form 1   MyoD   Nkx2-5   E4BP4   NRSF form 2   LCR-F1   AREB6   c-Myb   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DTX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.2

DTX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTX4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P058939:  view genomic region     (about GC identifiers)

Start:
58,938,903 bp from pter      End:
58,976,060 bp from pter
Size:
37,158 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DTX4_HUMAN, Q9Y2E6 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase DTX4  
Size: 619 amino acids; 67258 Da
Subunit: Interacts with NLRP4
Sequence caution: Sequence=BAA76781.1; Type=Erroneous initiation;
Secondary accessions: Q0VF38
Alternative splicing: 2 isoforms:  Q9Y2E6-1   Q9Y2E6-2   

Explore the universe of human proteins at neXtProt for DTX4: NX_Q9Y2E6

Explore proteomics data for DTX4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DTX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055992.1  
    ENSEMBL proteins: 
     ENSP00000434055   ENSP00000227451  
    Reactome Protein details: Q9Y2E6

    DTX4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DTX4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DTX4
    GenScript Custom Purified and Recombinant Proteins Services for DTX4
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DTX4

     
    Search eBioscience for Proteins for DTX4 

    DTX4 Antibody Products:

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    Abcam antibodies for DTX4
    Cloud-Clone Corp. Antibodies for DTX4
    Search ThermoFisher Antibodies for DTX4
    LSBio Antibodies in human, mouse, rat for DTX4

    DTX4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DTX4
    Cloud-Clone Corp. CLIAs for DTX4
    Search eBioscience for ELISAs for DTX4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR004170 WWE-dom
     IPR018123 WWE-dom_subgr
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y2E6

    ProtoNet protein and cluster: Q9Y2E6

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: DTX4_HUMAN, Q9Y2E6
    Domain: The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in
    ubiquitin ligases (By similarity)
    Similarity: Belongs to the Deltex family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 WWE domains


    Find genes that share domains with DTX4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DTX4_HUMAN, Q9Y2E6
    Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a
    broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo,
    mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires
    interaction with NLRP4

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with DTX4           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for DTX4:
     Increased cell death HMECs cel  Increased gamma-H2AX phosphory  Increased number of cells in m  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DTX4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DTX4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DTX4

    miRNA
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    miRTarBase miRNAs that target DTX4:
    hsa-mir-98-5p (MIRT027766)

    Block miRNA regulation of human, mouse, rat DTX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DTX4 (see all 68):
    hsa-miR-579 hsa-miR-642a hsa-miR-607 hsa-miR-128 hsa-miR-3916 hsa-miR-383 hsa-miR-4273 hsa-miR-27a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DTX4
    Predesigned siRNA for gene silencing in human, mouse, rat DTX4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DTX4

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DTX4 (NM_015177)
    Sino Biological Human cDNA Clone for DTX4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DTX4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DTX4_HUMAN, Q9Y2E6: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with DTX4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DTX4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH0.64
    3Cytosolic sensors of pathogen-associated DNA
    ZBP1(DAI) mediated induction of type I IFNs0.81
    Regulation of innate immune responses to cytosolic DNA0.00
    Cytosolic sensors of pathogen-associated DNA0.38
    STING mediated induction of host immune responses0.00
    IRF3 mediated activation of type 1 IFN0.00
    IRF3-mediated induction of type I IFN0.00
    4Signaling by NOTCH2
    Activated NOTCH1 Transmits Signal to the Nucleus0.61
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with DTX4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DTX4
        Notch Signaling Pathway


    4 Reactome Pathways for DTX4
        Regulation of innate immune responses to cytosolic DNA
    Activated NOTCH1 Transmits Signal to the Nucleus
    IRF3 mediated activation of type 1 IFN
    IRF3-mediated induction of type I IFN


    1 Kegg Pathway  (Kegg details for DTX4):
        Notch signaling pathway

    UniProtKB/Swiss-Prot: DTX4_HUMAN, Q9Y2E6
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including DTX4: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DTX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for DTX4 (Q9Y2E63 ENSP000002274514) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678703I2D: score=5 
    ENSG00000206406P678703I2D: score=5 
    ENSG00000224398P678703I2D: score=5 
    ENSG00000224774P678703I2D: score=5 
    ENSG00000228875P678703I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway IEA--
    GO:0016567protein ubiquitination IEA--
    GO:0032479regulation of type I interferon production TAS--
    GO:0032481positive regulation of type I interferon production TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with DTX4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DTX4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DTX4 gene: 
    NM_015177.1  

    Unigene Cluster for DTX4:

    Deltex homolog 4 (Drosophila)
    Hs.523696  [show with all ESTs]
    Unigene Representative Sequence: NM_015177
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532982 ENST00000227451(uc001nnr.2 uc001nns.2) ENST00000531902
    ENST00000527475
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DTX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DTX4 (see all 68):
    hsa-miR-579 hsa-miR-642a hsa-miR-607 hsa-miR-128 hsa-miR-3916 hsa-miR-383 hsa-miR-4273 hsa-miR-27a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DTX4
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    OriGene ORF clones in mouse, rat for DTX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DTX4 (NM_015177)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DTX4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTX4
      QuantiTect SYBR Green Assays in human, mouse, rat DTX4
      QuantiFast Probe-based Assays in human, mouse, rat DTX4

    Additional mRNA sequence: 

    AB023154.1 AF086290.1 BC015592.2 BC119011.1 BC122861.1 

    6 DOTS entries:

    DT.315109  DT.95304478  DT.86852856  DT.100700940  DT.95166859  DT.95166879 

    Selected AceView cDNA sequences (see all 166):

    AI078309 AW468955 BE675328 AI862931 AB023154 AL602075 AI014553 AW197004 
    AA344351 BG492311 AW589201 AF086290 T08372 AA716099 AI251759 BF439112 
    BQ028456 BM456588 AA346907 AA808423 BM712488 AI453415 BQ045149 AI589289 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DTX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTGTCTTT
    DTX4 Expression
    About this image


    DTX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             superior temporal gyrus   
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Heart (Cardiovascular System)
     
     Spinal Cord (Nervous System)
    DTX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DTX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523696
        Pathway & Disease-focused RT2 Profiler PCR Array including DTX4: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DTX4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTX4
    QuantiTect SYBR Green Assays in human, mouse, rat DTX4
    QuantiFast Probe-based Assays in human, mouse, rat DTX4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DTX4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtx41 , 5 deltex 4 homolog (Drosophila)1, 5 87.72(n)1
    94.32(a)1
      19 (8.72 cM)5
    2075211  NM_172442.31  NP_766030.31 
     124663415 
    chicken
    (Gallus gallus)
    Aves DTX41 deltex homolog 4 (Drosophila) 76.99(n)
    81.6(a)
      395516  XM_423367.4  XP_423367.4 
    lizard
    (Anolis carolinensis)
    Reptilia DTX46
    deltex homolog 4 (Drosophila)
    84(a)
    1 ↔ 1
    1(91153330-91197302)
    zebrafish
    (Danio rerio)
    Actinopterygii dtx11 deltex1 68.19(n)
    73.05(a)
      570481  NM_001127308.1  NP_001120780.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dx6
    deltex
    23(a)
    1 → many
    X(6428043-6432615)


    ENSEMBL Gene Tree for DTX4 (if available)
    TreeFam Gene Tree for DTX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for DTX4 gene
    DTX12  DTX3L2  DTX32  DTX22  
    3 SIMAP similar genes for DTX4 using alignment to 1 protein entry:     DTX4_HUMAN:
    DTX1    DTX2    DTX3

    Find genes that share paralogs with DTX4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DTX4 (see all 745)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161914291,2
    F--55283884(+) GGACAT/CAGGCA 1 -- int11Minor allele frequency- C:0.09WA 118
    rs1876777651,2
    --55283886(+) ACATAG/TGCAGG 1 -- int10--------
    rs798368221,2
    C,F--55283956(+) TGGTAG/ACCTGC 1 -- int12Minor allele frequency- A:0.03WA 120
    rs28399681,2
    C,F,A,H--55283959(+) TAGCCT/CGCTTA 1 -- int137Minor allele frequency- C:0.25NA NS EA WA 3558
    rs1510955841,2
    --55284047(+) TCCCCC/TTGAAT 1 -- int10--------
    rs800206561,2
    F--58937997(+) TCTTTC/TACACT 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs748319001,2
    C,F--58938041(+) CTCTGT/CGTTGT 1 -- us2k13Minor allele frequency- C:0.05WA CSA 121
    rs108969471,2
    C,F,A,H--58938083(+) TTGAGA/TCAGCC 1 -- us2k116Minor allele frequency- T:0.24NS EA NA WA 1262
    rs619022271,2
    C,F--58938150(+) TAGTTT/GAAATT 1 -- us2k17Minor allele frequency- G:0.25NA EA 250
    rs1401478271,2
    --58938281(+) TGTTTA/GGGTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DTX4 (58938903 - 58976060 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DTX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv386e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DTX4
    DNA2.0 Custom Variant and Variant Library Synthesis for DTX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DTX4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DTX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. (PubMed id 22388039)1, 2, 3 Cui J.... Wang R.F. (Nat. Immunol. 2012)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    3. Normal immune system development in mice lacking the Deltex-1 RING finger domain. (PubMed id 15684394)1, 2 Storck S.... Reynaud C.-A. (Mol. Cell. Biol. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    6. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23220 HGNC: 29151 AceView: DTX4 Ensembl:ENSG00000110042 euGenes: HUgn23220
    ECgene: DTX4 Kegg: 23220 H-InvDB: DTX4

    (According to HUGE)
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    HUGE: KIAA0937

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DTX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DTX4 gene:
    Search GeneIP for patents involving DTX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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