Aliases for DTX3L Gene
External Ids for DTX3L Gene
Previous GeneCards Identifiers for DTX3L Gene
DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
GeneCards Summary for DTX3L Gene
DTX3L (Deltex E3 Ubiquitin Ligase 3L) is a Protein Coding gene. Among its related pathways are DNA Damage and Notch signaling pathway (KEGG). GO annotations related to this gene include ligase activity and histone binding. An important paralog of this gene is DTX2.
UniProtKB/Swiss-Prot for DTX3L Gene
Ubiquitin ligase that mediates monoubiquitination of Lys-91 of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-20 methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.