DTX3L Gene
protein-coding GIFtS: 50
GCID: GC03P122284
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deltex 3-like (Drosophila)
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Aliases for DTX3L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Deltex 3-Like (Drosophila)1 2 | | Rhysin23 | | BBAP1 2 3 5 | | EC 6.3.2.-3 | | B-Lymphoma- And BAL-Associated Protein2 3 | | Rhysin-23 | | E3 Ubiquitin-Protein Ligase DTX3L2 | | Rhysin23 | | Rhysin 22 | | Protein Deltex-3-Like3 | | Rhysin-23 | | |
Export aliases for DTX3L gene to outside databasesPrevious GC identifers: GC03P123766 GC03P119656 |
Summaries for DTX3L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for DTX3L: DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)).(supplied by OMIM, Nov 2009) UniProtKB/Swiss-Prot: DTX3L_HUMAN, Q8TDB6Function: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNAdamage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is stillunclear but it may function as a licensing signal for additional histone H4 post-translational modifications such asH4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediatingH4K91ub1 formation
|
Genomic Views for DTX3L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DTX3L gene promoter: Bach1 AML1a Nkx2-5 C/EBPalpha MZF-1 CP2 GCNF-1 IRF-7A FOXO1a FOXO1 Other transcription factors
Search SABiosciences Chromatin IP Primers for DTX3L
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTX3L |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.1 Ensembl cytogenetic band: 3q21.1 HGNC cytogenetic band: 3q21.1DTX3L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P122284: view genomic region
(about GC identifiers)
Start:
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122,283,085 bp from pter |
End:
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122,294,050 bp from pter |
Size:
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10,966 bases |
Orientation:
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plus strand |
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Proteins for DTX3L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DTX3L_HUMAN, Q8TDB6 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase DTX3L Size: 740 amino acids; 83554 Da
Subunit: Homodimer and heterodimer. Can heterodimerize with DTX1, enhancing its ubiquitin ligase activity in vitro.Interacts with PARP9/BAL1. Found in a complex with MYO6
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from and Proteopedia for DTX3L:3PG6 (3D)
 
Secondary accessions: B3KWH6 Q53ZZ3 Q5MJP7Alternative splicing: 2 isoforms: Q8TDB6-1 Q8TDB6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DTX3L: NX_Q8TDB6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TDB6 DTX3L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612144.1 ENSEMBL proteins: ENSP00000296161 ENSP00000373157 Reactome Protein details: Q8TDB6 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
DTX3L for ontologies About GeneDecksing
DTX3L Antibody Products: Assay Products for DTX3L: |
Protein
Domains / Families for DTX3L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DTX3L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TDB6ProtoNet protein and cluster: Q8TDB6 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: DTX3L_HUMAN, Q8TDB6Similarity: Belongs to the Deltex familySimilarity: Contains 1 RING-type zinc finger |
Function for DTX3L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: DTX3L_HUMAN, Q8TDB6Function: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNAdamage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is stillunclear but it may function as a licensing signal for additional histone H4 post-translational modifications such asH4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediatingH4K91ub1 formationInduction: By IFNG/IFN-gammaEnzyme Number (IUBMB): EC 6.3.2.-1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DTX3L (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DTX3L OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DTX3L (NM_138287) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DTX3L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX3L  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX3L |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
DTX3L for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DTX3L:
|
Pathways & Interactions for DTX3L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | | | 3 | Notch Signaling Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
1 BioSystems Pathway for DTX3L 
5
Reactome Pathways for DTX3L
1
Kegg Pathway (Kegg details for DTX3L): UniProtKB/Swiss-Prot: DTX3L_HUMAN, Q8TDB6Pathway: Protein modification; protein ubiquitination
DTX3L for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DTX3L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
 5/41 Interacting proteins for DTX3L (Q8TDB63 ENSP000002961614) via UniProtKB, MINT, STRING, and/or I2D (see all 41) About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
DTX3L for ontologies About GeneDecksing
|
Drugs & Compounds for DTX3L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for DTX3L Search CenterWatch for drugs/clinical trials and news about DTX3L 
|
Transcripts for DTX3L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DTX3L gene: NM_138287.3 Unigene Cluster for DTX3L: Deltex 3-like (Drosophila) Hs.518201 [show with all ESTs]Unigene Representative Sequence: BX6482672 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000296161(uc003efk.3 uc010hrj.3) ENST00000383661
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DTX3L (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DTX3L OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DTX3L (NM_138287) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DTX3L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX3L  |
Additional cDNA sequence: AF484416.1 AK025135.1 AK056406.1 AK093782.1 AK125086.1 AL833598.1 AY225123.1 AY780792.1 BC016846.2 BC040372.1 BC042191.1 BC060509.1 BX648267.1 BX648645.1 8 DOTS entries: DT.95164903 DT.316670 DT.120924882 DT.100033398 DT.100033874 DT.100793605 DT.100793607 DT.87015902 24/195 AceView cDNA sequences (see all 195): BC042191 BU686482 AI659256 BU172335 AA577672 AI380800 CB269634 BM467961 AF484416 BM769101 AI473584 BQ435134 BQ428321 AY225123 AA301252 BU195281 AW772239 BM478541 AA513421 BM454871 BE502052 BP380033 AI520826 N57147 GeneLoc Exon Structure
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Expression for DTX3L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DTX3L expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GTGTGGGAGA
About this image See DTX3L Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DTX3L
SOURCE GeneReport for Unigene cluster: Hs.518201 SABiosciences Custom PCR Arrays for DTX3L
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DTX3L Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DTX3L | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTX3L | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTX3L | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX3L |
Orthologs for DTX3L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DTX3L gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for DTX3L (if available) TreeFam Gene Tree for DTX3L (if available)  |
Paralogs for DTX3L gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for DTX3L gene
- DTX42 DTX12 DTX32 DTX22
1 SIMAP similar gene for DTX3L using alignment to 1 protein entry: DTX3L_HUMAN:DTX3
DTX3L for paralogs About GeneDecksing
|
Genomic Variants for DTX3L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for DTX3L (122283085 - 122294050 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DTX3L: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DTX3L |
|
Disorders
/ Diseases for DTX3L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DTX3L for disorders About GeneDecksing
OMIM gene information: 613143
OMIM disorders: --
4 diseases for DTX3L: About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas cervical cancer cervicitis Export disorders for DTX3L gene to outside databases
|
Publications for DTX3L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DTX3L gene, integrated from 9 sources (see all 23): (articles sorted by number of sources associating them with DTX3L) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PubMed id 12670957)1, 2, 3, 9 Takeyama K.... Shipp M.A. (2003)
- Fold of the conserved DTC domain in deltex proteins. (PubMed id 22411408)1, 2 Obiero J.... Dhe-Paganon S. (2012)
- BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PubMed id 19818714)1, 2 Yan Q....Shipp M.A. (2009)
- BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. (PubMed id 16809771)1, 2 Juszczynski P....Shipp M.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1 (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
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External Searches for DTX3L gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DTX3L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DTX3L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DTX3L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for DTX3L | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DTX3L gene: Search GeneIP for patents involving DTX3L
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for DTX3L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for DTX3L | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DTX3L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DTX3L | | OriGene Protein Over-expression Lysate for DTX3L | | Browse OriGene Fluorogenic Cell Assay Kits | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for DTX3L | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DTX3L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DTX3L | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for DTX3L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DTX3L | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DTX3L | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTX3L | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTX3L | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTX3L | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTX3L |
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| | | Search Tocris compounds for DTX3L |
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 | | DTX3L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX3L |
|  |  |  | | | Search ThermoFisher Antibodies for DTX3L |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX3L |
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