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Aliases for DTX3L Gene

Aliases for DTX3L Gene

  • Deltex E3 Ubiquitin Ligase 3L 2 3 5
  • RING-Type E3 Ubiquitin Transferase DTX3L 3 4
  • B-Lymphoma- And BAL-Associated Protein 3 4
  • Rhysin-2 3 4
  • Rhysin2 3 4
  • BBAP 3 4
  • Deltex 3 Like, E3 Ubiquitin Ligase 3
  • E3 Ubiquitin-Protein Ligase DTX3L 3
  • Deltex 3-Like (Drosophila) 2
  • Protein Deltex-3-Like 4
  • Deltex 3-Like 3
  • EC 2.3.2.27 4
  • Rhysin 2 2

External Ids for DTX3L Gene

Previous GeneCards Identifiers for DTX3L Gene

  • GC03P123766
  • GC03P122284
  • GC03P119656

Summaries for DTX3L Gene

Entrez Gene Summary for DTX3L Gene

  • DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

GeneCards Summary for DTX3L Gene

DTX3L (Deltex E3 Ubiquitin Ligase 3L) is a Protein Coding gene. Among its related pathways are DNA Damage and Notch signaling pathway (KEGG). GO annotations related to this gene include ligase activity and histone binding. An important paralog of this gene is DTX2.

UniProtKB/Swiss-Prot for DTX3L Gene

  • Ubiquitin ligase that mediates monoubiquitination of Lys-91 of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-20 methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

Additional gene information for DTX3L Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX3L Gene

Genomics for DTX3L Gene

Regulatory Elements for DTX3L Gene

Enhancers for DTX3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H122678 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +117.1 117060 5 HDGF SIN3A ZNF2 YY1 GLIS2 ZNF143 ZNF207 ATF7 RUNX3 YY2 PARP14 DTX3L PARP9 HSPBAP1 DIRC2 LINC02035 CSTA KPNA1
GH03H122773 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +209.9 209903 1 CTCF PKNOX1 FOSL1 EED ATF7 IKZF2 SMARCA5 ZNF687 HLF NR2F1 PARP14 HSPBAP1 DTX3L PARP9 DIRC2 CSTA KPNA1
GH03H122073 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -486.8 -486809 7 HDGF PKNOX1 FOXA2 TBL1XR1 SIN3A BMI1 BATF RFX5 ZNF143 ATF7 CD86 ENSG00000202388 DTX3L PARP9 CCDC58 FAM162A IQCB1 EAF2 CSTA HCLS1
GH03H122766 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +204.1 204084 3 POLR2A DIRC2 HSPBAP1 PARP14 PARP9 DTX3L LINC02035 CSTA KPNA1
GH03H122099 1.3 FANTOM5 ENCODE dbSUPER 9.2 -463.9 -463946 2 CTCF ZNF687 RFX1 CHD4 RFX5 EED CREB1 IKZF2 CREM PARP9 DTX3L CD86 HCLS1 CSTA EAF2 ILDR1 CASR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DTX3L on UCSC Golden Path with GeneCards custom track

Promoters for DTX3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157339 62 1801 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ZNF143 KLF7 ATF7 SP3

Genomic Location for DTX3L Gene

Chromosome:
3
Start:
122,564,238 bp from pter
End:
122,575,203 bp from pter
Size:
10,966 bases
Orientation:
Plus strand

Genomic View for DTX3L Gene

Genes around DTX3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTX3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTX3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX3L Gene

Proteins for DTX3L Gene

  • Protein details for DTX3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDB6-DTX3L_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase DTX3L
    Protein Accession:
    Q8TDB6
    Secondary Accessions:
    • B3KWH6
    • Q53ZZ3
    • Q5MJP7

    Protein attributes for DTX3L Gene

    Size:
    740 amino acids
    Molecular mass:
    83554 Da
    Quaternary structure:
    • Homodimer and heterodimer. Can heterodimerize with DTX1, enhancing its ubiquitin ligase activity in vitro. Interacts with PARP9/BAL1. Found in a complex with MYO6.

    Three dimensional structures from OCA and Proteopedia for DTX3L Gene

    Alternative splice isoforms for DTX3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX3L Gene

Post-translational modifications for DTX3L Gene

  • Ubiquitination at isoforms=198, posLast=232232, posLast=259259, posLast=316316, isoforms=337, isoforms=401, posLast=593593, posLast=653653, posLast=675675, posLast=709709, and isoforms=2728
  • Modification sites at PhosphoSitePlus

Other Protein References for DTX3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DTX3L Gene

Domains & Families for DTX3L Gene

Gene Families for DTX3L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DTX3L Gene

Suggested Antigen Peptide Sequences for DTX3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDB6

UniProtKB/Swiss-Prot:

DTX3L_HUMAN :
  • Belongs to the Deltex family.
Family:
  • Belongs to the Deltex family.
genes like me logo Genes that share domains with DTX3L: view

Function for DTX3L Gene

Molecular function for DTX3L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Ubiquitin ligase that mediates monoubiquitination of Lys-91 of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-20 methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma.

Enzyme Numbers (IUBMB) for DTX3L Gene

Phenotypes From GWAS Catalog for DTX3L Gene

Gene Ontology (GO) - Molecular Function for DTX3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0004857 enzyme inhibitor activity IMP 24790097
GO:0005515 protein binding IPI 16809771
GO:0008047 enzyme activator activity IDA 28525742
genes like me logo Genes that share ontologies with DTX3L: view
genes like me logo Genes that share phenotypes with DTX3L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DTX3L
  • Applied Biological Materials Clones for DTX3L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTX3L Gene

Localization for DTX3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX3L Gene

Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTX3L gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DTX3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 colocalizes_with nucleus IEA,IDA 26479788
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 16809771
GO:0005764 lysosome IDA 24790097
GO:0005769 colocalizes_with early endosome IDA 24790097
genes like me logo Genes that share ontologies with DTX3L: view

Pathways & Interactions for DTX3L Gene

genes like me logo Genes that share pathways with DTX3L: view

Pathways by source for DTX3L Gene

1 GeneTex pathway for DTX3L Gene
2 Cell Signaling Technology pathways for DTX3L Gene
1 BioSystems pathway for DTX3L Gene

UniProtKB/Swiss-Prot Q8TDB6-DTX3L_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DTX3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0002230 positive regulation of defense response to virus by host IGI 26479788
GO:0006281 DNA repair IEA --
GO:0006302 double-strand break repair IMP 23230272
GO:0006974 cellular response to DNA damage stimulus IMP 19818714
genes like me logo Genes that share ontologies with DTX3L: view

No data available for SIGNOR curated interactions for DTX3L Gene

Drugs & Compounds for DTX3L Gene

No Compound Related Data Available

Transcripts for DTX3L Gene

mRNA/cDNA for DTX3L Gene

Unigene Clusters for DTX3L Gene

Deltex 3-like (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DTX3L
  • Applied Biological Materials Clones for DTX3L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DTX3L Gene

No ASD Table

Relevant External Links for DTX3L Gene

GeneLoc Exon Structure for
DTX3L
ECgene alternative splicing isoforms for
DTX3L

Expression for DTX3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTX3L Gene

Protein differential expression in normal tissues from HIPED for DTX3L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.8), Lymph node (13.8), and Pancreas (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DTX3L Gene



Protein tissue co-expression partners for DTX3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DTX3L Gene:

DTX3L

SOURCE GeneReport for Unigene cluster for DTX3L Gene:

Hs.518201

Evidence on tissue expression from TISSUES for DTX3L Gene

  • Liver(4.4)
genes like me logo Genes that share expression patterns with DTX3L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTX3L Gene

Orthologs for DTX3L Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTX3L 33 34
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia DTX3L 33 34
  • 78.58 (n)
dog
(Canis familiaris)
Mammalia DTX3L 33 34
  • 77.95 (n)
rat
(Rattus norvegicus)
Mammalia Dtx3l 33
  • 72.56 (n)
mouse
(Mus musculus)
Mammalia Dtx3l 33 16 34
  • 70.52 (n)
oppossum
(Monodelphis domestica)
Mammalia DTX3L 34
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTX3L 34
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTX3L 34 33
  • 52.89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTX3L 34
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DTX3L 34
  • 20 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dx 34
  • 17 (a)
OneToMany
Species where no ortholog for DTX3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX3L Gene

ENSEMBL:
Gene Tree for DTX3L (if available)
TreeFam:
Gene Tree for DTX3L (if available)

Paralogs for DTX3L Gene

Paralogs for DTX3L Gene

(1) SIMAP similar genes for DTX3L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DTX3L: view

Variants for DTX3L Gene

Sequence variations from dbSNP and Humsavar for DTX3L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_036098 A breast cancer sample
rs1000455364 -- 122,571,256(+) CGATG(A/C)CCCCC intron-variant
rs1000724738 -- 122,572,651(+) TGGCT(C/T)ACTGC utr-variant-3-prime
rs1000819033 -- 122,566,193(+) TAGGC(A/G)CTGGA intron-variant, upstream-variant-2KB
rs1001535967 -- 122,563,304(+) CCAGT(C/G)TGAAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DTX3L Gene

Variant ID Type Subtype PubMed ID
esv2672720 CNV deletion 23128226
esv3597613 CNV loss 21293372

Variation tolerance for DTX3L Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTX3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTX3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX3L Gene

Disorders for DTX3L Gene

Relevant External Links for DTX3L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTX3L

No disorders were found for DTX3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTX3L Gene

Publications for DTX3L Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K … Shipp MA (The Journal of biological chemistry 2003) 2 3 4 22 60
  2. Fold of the conserved DTC domain in Deltex proteins. (PMID: 22411408) Obiero J … Dhe-Paganon S (Proteins 2012) 2 3 4 60
  3. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. (PMID: 23230272) Yan Q … Shipp MA (Molecular and cellular biology 2013) 3 4 60
  4. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PMID: 19818714) Yan Q … Shipp MA (Molecular cell 2009) 3 4 60
  5. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. (PMID: 16809771) Juszczynski P … Shipp MA (Molecular and cellular biology 2006) 3 4 60

Products for DTX3L Gene

  • Addgene plasmids for DTX3L

Sources for DTX3L Gene

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