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Aliases for DTX3L Gene

Aliases for DTX3L Gene

  • Deltex 3 Like, E3 Ubiquitin Ligase 2 3 5
  • B-Lymphoma- And BAL-Associated Protein 3 4
  • Rhysin 2 2 3
  • Rhysin-2 3 4
  • Rhysin2 3 4
  • BBAP 3 4
  • Deltex 3-Like (Drosophila) 2
  • Protein Deltex-3-Like 4
  • Deltex 3-Like 3
  • EC 6.3.2.- 4

External Ids for DTX3L Gene

Previous GeneCards Identifiers for DTX3L Gene

  • GC03P123766
  • GC03P122284
  • GC03P119656

Summaries for DTX3L Gene

Entrez Gene Summary for DTX3L Gene

  • DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

GeneCards Summary for DTX3L Gene

DTX3L (Deltex 3 Like, E3 Ubiquitin Ligase) is a Protein Coding gene. Among its related pathways are Immune System and Notch signaling pathway (KEGG). GO annotations related to this gene include ligase activity and histone binding. An important paralog of this gene is DTX3.

UniProtKB/Swiss-Prot for DTX3L Gene

  • Ubiquitin ligase that mediates monoubiquitination of Lys-91 of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-20 methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX3L Gene

Genomics for DTX3L Gene

Regulatory Elements for DTX3L Gene

Promoters for DTX3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DTX3L on UCSC Golden Path with GeneCards custom track

Genomic Location for DTX3L Gene

Chromosome:
3
Start:
122,564,238 bp from pter
End:
122,575,203 bp from pter
Size:
10,966 bases
Orientation:
Plus strand

Genomic View for DTX3L Gene

Genes around DTX3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTX3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTX3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX3L Gene

Proteins for DTX3L Gene

  • Protein details for DTX3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDB6-DTX3L_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase DTX3L
    Protein Accession:
    Q8TDB6
    Secondary Accessions:
    • B3KWH6
    • Q53ZZ3
    • Q5MJP7

    Protein attributes for DTX3L Gene

    Size:
    740 amino acids
    Molecular mass:
    83554 Da
    Quaternary structure:
    • Homodimer and heterodimer. Can heterodimerize with DTX1, enhancing its ubiquitin ligase activity in vitro. Interacts with PARP9/BAL1. Found in a complex with MYO6.

    Three dimensional structures from OCA and Proteopedia for DTX3L Gene

    Alternative splice isoforms for DTX3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX3L Gene

Proteomics data for DTX3L Gene at MOPED

Post-translational modifications for DTX3L Gene

  • Ubiquitination at Lys 198, Lys 232, Lys 259, Lys 316, Lys 337, Lys 401, Lys 593, Lys 653, Lys 675, Lys 709, and Lys 728
  • Modification sites at PhosphoSitePlus

Other Protein References for DTX3L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DTX3L (DTX3L)

No data available for DME Specific Peptides for DTX3L Gene

Domains & Families for DTX3L Gene

Gene Families for DTX3L Gene

Protein Domains for DTX3L Gene

Suggested Antigen Peptide Sequences for DTX3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDB6

UniProtKB/Swiss-Prot:

DTX3L_HUMAN :
  • Belongs to the Deltex family.
  • Contains 1 RING-type zinc finger.
Family:
  • Belongs to the Deltex family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with DTX3L: view

Function for DTX3L Gene

Molecular function for DTX3L Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin ligase that mediates monoubiquitination of Lys-91 of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-20 methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma.

Enzyme Numbers (IUBMB) for DTX3L Gene

Gene Ontology (GO) - Molecular Function for DTX3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
GO:0042393 histone binding IDA 19818714
genes like me logo Genes that share ontologies with DTX3L: view
genes like me logo Genes that share phenotypes with DTX3L: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTX3L Gene

Localization for DTX3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX3L Gene

Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTX3L Gene COMPARTMENTS Subcellular localization image for DTX3L gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DTX3L Gene

Pathways & Interactions for DTX3L Gene

genes like me logo Genes that share pathways with DTX3L: view

Pathways by source for DTX3L Gene

1 GeneTex pathway for DTX3L Gene
1 BioSystems pathway for DTX3L Gene

UniProtKB/Swiss-Prot Q8TDB6-DTX3L_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DTX3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair IMP 23230272
genes like me logo Genes that share ontologies with DTX3L: view

No data available for SIGNOR curated interactions for DTX3L Gene

Drugs & Compounds for DTX3L Gene

No Compound Related Data Available

Transcripts for DTX3L Gene

mRNA/cDNA for DTX3L Gene

Unigene Clusters for DTX3L Gene

Deltex 3-like (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTX3L Gene

No ASD Table

Relevant External Links for DTX3L Gene

GeneLoc Exon Structure for
DTX3L
ECgene alternative splicing isoforms for
DTX3L

Expression for DTX3L Gene

mRNA expression in normal human tissues for DTX3L Gene

Protein differential expression in normal tissues from HIPED for DTX3L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.8), Lymph node (13.8), and Pancreas (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DTX3L Gene



SOURCE GeneReport for Unigene cluster for DTX3L Gene Hs.518201

genes like me logo Genes that share expression patterns with DTX3L: view

Protein tissue co-expression partners for DTX3L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DTX3L Gene

Orthologs for DTX3L Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTX3L 35
  • 99.59 (n)
  • 99.19 (a)
DTX3L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DTX3L 36
  • 65 (a)
OneToOne
DTX3L 35
  • 78.58 (n)
  • 65.21 (a)
dog
(Canis familiaris)
Mammalia DTX3L 35
  • 77.95 (n)
  • 66.71 (a)
DTX3L 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtx3l 16
Dtx3l 36
  • 57 (a)
OneToOne
Dtx3l 35
  • 70.52 (n)
  • 60.33 (a)
oppossum
(Monodelphis domestica)
Mammalia DTX3L 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTX3L 36
  • 31 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtx3l 35
  • 72.56 (n)
  • 63.11 (a)
chicken
(Gallus gallus)
Aves DTX3L 35
  • 52.89 (n)
  • 39.63 (a)
DTX3L 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTX3L 36
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DTX3L 36
  • 20 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dx 36
  • 17 (a)
OneToMany
Species with no ortholog for DTX3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX3L Gene

ENSEMBL:
Gene Tree for DTX3L (if available)
TreeFam:
Gene Tree for DTX3L (if available)

Paralogs for DTX3L Gene

Paralogs for DTX3L Gene

(1) SIMAP similar genes for DTX3L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DTX3L: view

Variants for DTX3L Gene

Sequence variations from dbSNP and Humsavar for DTX3L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_036098 A breast cancer sample
rs2332285 - 122,569,363(+) GGACA(A/G)GCAGG reference, missense
rs9868175 - 122,570,522(+) TAATA(A/T)GGAAG reference, missense
rs1045089 -- 122,574,362(+) TTAAA(C/T)GGTTC utr-variant-3-prime
rs7616403 -- 122,572,506(+) TTCTG(C/T)TTTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DTX3L Gene

Variant ID Type Subtype PubMed ID
nsv877391 CNV Gain 21882294
esv2672720 CNV Deletion 23128226

Variation tolerance for DTX3L Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTX3L Gene

HapMap Linkage Disequilibrium report
DTX3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX3L Gene

Disorders for DTX3L Gene

Relevant External Links for DTX3L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTX3L

No disorders were found for DTX3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTX3L Gene

Publications for DTX3L Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K. … Shipp M.A. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. Fold of the conserved DTC domain in deltex proteins. (PMID: 22411408) Obiero J. … Dhe-Paganon S. (Proteins 2012) 2 3
  3. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. (PMID: 24886089) Bachmann S.B. … Hassa P.O. (Mol. Cancer 2014) 3

Products for DTX3L Gene

Sources for DTX3L Gene

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