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DTX3L Gene

protein-coding   GIFtS: 55
GCID: GC03P122284

Deltex 3 Like, E3 Ubiquitin Ligase

(Previous name: deltex 3-like (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deltex 3 Like, E3 Ubiquitin Ligase1 2     rhysin-22
BBAP2 3 5     rhysin22
Rhysin 21 2     EC 6.3.2.-3
B-Lymphoma- And BAL-Associated Protein2 3     Rhysin-23
Deltex 3-Like (Drosophila)1     Rhysin23
Deltex 3-Like2     Protein Deltex-3-Like3
E3 Ubiquitin-Protein Ligase DTX3L2     

External Ids:    HGNC: 303231   Entrez Gene: 1516362   Ensembl: ENSG000001638407   OMIM: 6131435   UniProtKB: Q8TDB63   

Export aliases for DTX3L gene to outside databases

Previous GC identifers: GC03P123766 GC03P119656


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DTX3L Gene:
DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)).(supplied by OMIM, Nov 2009)

GeneCards Summary for DTX3L Gene:
DTX3L (deltex 3 like, E3 ubiquitin ligase) is a protein-coding gene. Diseases associated with DTX3L include major depressive disorder, and diffuse large b-cell lymphoma. GO annotations related to this gene include ubiquitin-protein ligase activity and histone binding. An important paralog of this gene is DTX1.

UniProtKB/Swiss-Prot: DTX3L_HUMAN, Q8TDB6
Function: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to
DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is
still unclear but it may function as a licensing signal for additional histone H4 post-translational
modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of
DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage
repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of
53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the DTX3L gene promoter:
         Bach1   AML1a   Nkx2-5   C/EBPalpha   MZF-1   CP2   GCNF-1   IRF-7A   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDTX3L promoter sequence
   Search Chromatin IP Primers for DTX3L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTX3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.1   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21.1

DTX3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTX3L gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P122284:  view genomic region     (about GC identifiers)

Start:
122,283,085 bp from pter      End:
122,294,050 bp from pter
Size:
10,966 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DTX3L_HUMAN, Q8TDB6 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase DTX3L  
Size: 740 amino acids; 83554 Da
Subunit: Homodimer and heterodimer. Can heterodimerize with DTX1, enhancing its ubiquitin ligase activity in
vitro. Interacts with PARP9/BAL1. Found in a complex with MYO6
1 PDB 3D structure from and Proteopedia for DTX3L:
3PG6 (3D)    
Secondary accessions: B3KWH6 Q53ZZ3 Q5MJP7
Alternative splicing: 2 isoforms:  Q8TDB6-1   Q8TDB6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DTX3L: NX_Q8TDB6

Explore proteomics data for DTX3L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys198, Lys232, Lys259, Lys306, Lys316, Lys337, Lys401, Lys593, Lys653, Lys675,
                                 Lys709, Lys728
  • Modification sites at PhosphoSitePlus

  • See DTX3L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612144.1  
    ENSEMBL proteins: 
     ENSP00000296161   ENSP00000373157  
    Reactome Protein details: Q8TDB6

    DTX3L Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8TDB6

    ProtoNet protein and cluster: Q8TDB6

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: DTX3L_HUMAN, Q8TDB6
    Similarity: Belongs to the Deltex family
    Similarity: Contains 1 RING-type zinc finger


    DTX3L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DTX3L_HUMAN, Q8TDB6
    Function: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to
    DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is
    still unclear but it may function as a licensing signal for additional histone H4 post-translational
    modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of
    DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage
    repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of
    53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites
    Induction: By IFNG/IFN-gamma

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP--
    GO:0005515protein binding IPI16809771
    GO:0008270zinc ion binding IEA--
    GO:0042393histone binding IDA19818714
         
    DTX3L for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DTX3L:
     Decreased Hepatitis C virus re  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DTX3L
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    miRNA
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    miRTarBase miRNAs that target DTX3L:
    hsa-mir-21-5p (MIRT030687)

    Block miRNA regulation of human, mouse, rat DTX3L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DTX3L (see all 27):
    hsa-miR-100* hsa-miR-4251 hsa-miR-4328 hsa-miR-340 hsa-miR-519a hsa-miR-373* hsa-miR-508-5p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidDTX3L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DTX3L

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    Sino Biological Human cDNA Clone for DTX3L
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX3L

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX3L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DTX3L_HUMAN, Q8TDB6: Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    DTX3L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DTX3L About    
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DTX3L
        Notch Signaling Pathway


    1 Reactome Pathway for DTX3L
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for DTX3L):
        Notch signaling pathway

    UniProtKB/Swiss-Prot: DTX3L_HUMAN, Q8TDB6
    Pathway: Protein modification; protein ubiquitination


    DTX3L for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DTX3L
    Interactions:

        GeneGlobe Interaction Network for DTX3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DTX3L (Q8TDB63 ENSP000002961614) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006302double-strand break repair IMP--
    GO:0006974cellular response to DNA damage stimulus IMP19818714
    GO:0010390histone monoubiquitination IDA19818714

    DTX3L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DTX3L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DTX3L gene: 
    NM_138287.3  

    Unigene Cluster for DTX3L:

    Deltex 3-like (Drosophila)
    Hs.518201  [show with all ESTs]
    Unigene Representative Sequence: BX648267
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296161(uc003efk.3 uc010hrj.3) ENST00000383661
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DTX3L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DTX3L (see all 27):
    hsa-miR-100* hsa-miR-4251 hsa-miR-4328 hsa-miR-340 hsa-miR-519a hsa-miR-373* hsa-miR-508-5p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidDTX3L 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: DTX3L (NM_138287)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX3L
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DTX3L
      QuantiFast Probe-based Assays in human, mouse, rat DTX3L

    Additional mRNA sequence: 

    AF484416.1 AK025135.1 AK056406.1 AK093782.1 AK125086.1 AL833598.1 AY225123.1 AY780792.1 
    BC016846.2 BC040372.1 BC042191.1 BC060509.1 BX648267.1 BX648645.1 

    8 DOTS entries:

    DT.95164903  DT.316670  DT.120924882  DT.100033398  DT.100033874  DT.100793605  DT.100793607  DT.87015902 

    Selected AceView cDNA sequences (see all 195):

    BQ428321 AI274035 AI520826 AA577672 BU195281 NM_138287 CA440453 BM769101 
    AW026888 AA952891 BM467961 BM478541 CB161337 AI753715 AI659256 BX483261 
    AI473584 AA301252 BU172335 BP348508 AW772239 AF484416 AY225123 BU154891 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DTX3L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTGGGAGA
    DTX3L Expression
    About this image

    DTX3L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DTX3L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518201
        Custom PCR Arrays for DTX3L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX3L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DTX3L gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtx3l1 , 5 deltex 3-like (Drosophila)1, 5 70.52(n)1
    60.33(a)1
      16 (25.43 cM)5
    2092001  NM_001013371.21  NP_001013389.21 
     359265115 
    chicken
    (Gallus gallus)
    Aves DTX3L1 deltex 3-like (Drosophila) 52.89(n)
    39.63(a)
      424267  XM_422114.4  XP_422114.4 
    lizard
    (Anolis carolinensis)
    Reptilia DTX3L6
    deltex 3-like (Drosophila)
    36(a)
    1 ↔ 1
    1(77444413-77454717)
    zebrafish
    (Danio rerio)
    Actinopterygii DTX3L6
    deltex 3-like (Drosophila)
    20(a)
    1 ↔ 1
    11(1550019-1572550) ENSDARG00000075504
    fruit fly
    (Drosophila melanogaster)
    Insecta dx6
    deltex
    17(a)
    1 → many
    X(6428043-6432615)


    ENSEMBL Gene Tree for DTX3L (if available)
    TreeFam Gene Tree for DTX3L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DTX3L gene
    DTX12  DTX42  DTX32  DTX22  
    1 SIMAP similar gene for DTX3L using alignment to 1 protein entry:     DTX3L_HUMAN:
    DTX3

    DTX3L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DTX3L (see all 220)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360984
    A breast cancer sample4--see VAR_0360982 K N mis40--------
    rs1811172741,2
    --122285616(+) ACTGCC/GTACTG 1 -- int10--------
    rs622638671,2
    C--122285672(+) GGCAGA/TCTCGG 1 -- int13Minor allele frequency- T:0.06NA EA 242
    rs99177291,2
    C,F,A,H--122285701(+) TCTAGT/AGAGAG 1 -- int1 trp313Minor allele frequency- A:0.39NS EA WA NA CSA 787
    rs1400437361,2
    --122285918(+) GAGCTA/GACATT 1 -- int10--------
    rs124862851,2
    C,F,H--122286160(+) TGAACG/ATAGAA 1 -- int19Minor allele frequency- A:0.21NS EA NA CSA WA 780
    rs117069141,2
    C,H--122286163(+) acgtaG/Taaagg 1 -- int1 trp34Minor allele frequency- T:0.00NS EA 416
    rs1449286061,2
    --122286208(+) GGTTGC/TAGTGC 1 -- int10--------
    rs1858920871,2
    --122286276(+) ATGGCG/TGGATT 1 -- int10--------
    rs1898184451,2
    --122286410(+) CTGGCA/GTGTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for DTX3L (122283085 - 122294050 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DTX3L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672720CNV Deletion23128226
    nsv877391CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613143    OMIM disorders: --

    7 diseases for DTX3L:    
    About MalaCards
    major depressive disorder    diffuse large b-cell lymphoma    b-cell lymphomas    breast and colorectal cancer
    cervical cancer    cervicitis    colorectal cancer


    DTX3L for disorders           About GeneDecksing


    Export disorders for DTX3L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DTX3L gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with DTX3L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PubMed id 12670957)1, 2, 3, 9 Takeyama K.... Shipp M.A. (J. Biol. Chem. 2003)
    2. Fold of the conserved DTC domain in deltex proteins. (PubMed id 22411408)1, 2, 3 Obiero J.... Dhe-Paganon S. (Proteins 2012)
    3. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. (PubMed id 23230272)1, 2 Yan Q.... Shipp M.A. (Mol. Cell. Biol. 2013)
    4. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PubMed id 19818714)1, 2 Yan Q....Shipp M.A. (Mol. Cell 2009)
    5. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. (PubMed id 16809771)1, 2 Juszczynski P....Shipp M.A. (Mol. Cell. Biol. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1  ....Sullivan P.F. (Mol. Psychiatry 2013)
    9. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 151636 HGNC: 30323 AceView: BBAP Ensembl:ENSG00000163840 euGenes: HUgn151636
    ECgene: DTX3L Kegg: 151636 H-InvDB: DTX3L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DTX3L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DTX3L gene:
    Search GeneIP for patents involving DTX3L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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