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Aliases for DTX3L Gene

Aliases for DTX3L Gene

  • Deltex 3 Like, E3 Ubiquitin Ligase 2 3
  • BBAP 3 4 6
  • B-Lymphoma- And BAL-Associated Protein 3 4
  • Rhysin 2 2 3
  • Rhysin-2 3 4
  • Rhysin2 3 4
  • E3 Ubiquitin-Protein Ligase DTX3L 3
  • Deltex 3-Like (Drosophila) 2
  • Protein Deltex-3-Like 4
  • Deltex 3-Like 3
  • EC 6.3.2.- 4

External Ids for DTX3L Gene

Summaries for DTX3L Gene

Entrez Gene Summary for DTX3L Gene

  • DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

GeneCards Summary for DTX3L Gene

DTX3L (Deltex 3 Like, E3 Ubiquitin Ligase) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and histone binding. An important paralog of this gene is DTX4.

UniProtKB/Swiss-Prot for DTX3L Gene

  • Ubiquitin ligase that mediates monoubiquitination of Lys-91 of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-20 methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX3L Gene

Genomics for DTX3L Gene

Genomic Location for DTX3L Gene

Start:
122,564,238 bp from pter
End:
122,575,203 bp from pter
Size:
10,966 bases
Orientation:
Plus strand

Genomic View for DTX3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTX3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX3L Gene

Regulatory Elements for DTX3L Gene

Proteins for DTX3L Gene

  • Protein details for DTX3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDB6-DTX3L_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase DTX3L
    Protein Accession:
    Q8TDB6
    Secondary Accessions:
    • B3KWH6
    • Q53ZZ3
    • Q5MJP7

    Protein attributes for DTX3L Gene

    Size:
    740 amino acids
    Molecular mass:
    83554 Da
    Quaternary structure:
    • Homodimer and heterodimer. Can heterodimerize with DTX1, enhancing its ubiquitin ligase activity in vitro. Interacts with PARP9/BAL1. Found in a complex with MYO6.

    Three dimensional structures from OCA and Proteopedia for DTX3L Gene

    Alternative splice isoforms for DTX3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX3L Gene

Proteomics data for DTX3L Gene at MOPED

Post-translational modifications for DTX3L Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys198, Lys232, Lys259, Lys306, Lys316, Lys337, Lys401, Lys593, Lys653, Lys675, Lys709, and Lys728

Other Protein References for DTX3L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DTX3L Gene

Domains for DTX3L Gene

Gene Families for DTX3L Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for DTX3L Gene

UniProtKB/Swiss-Prot:

DTX3L_HUMAN
Family:
  • Belongs to the Deltex family.:
    • Q8TDB6
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q8TDB6
genes like me logo Genes that share domains with DTX3L: view

Function for DTX3L Gene

Molecular function for DTX3L Gene

UniProtKB/Swiss-Prot Function: Ubiquitin ligase that mediates monoubiquitination of Lys-91 of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-20 methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma.

Enzyme Numbers (IUBMB) for DTX3L Gene

Gene Ontology (GO) - Molecular Function for DTX3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 23230272
GO:0005515 protein binding IPI 16809771
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0042393 histone binding IDA 19818714
genes like me logo Genes that share ontologies with DTX3L: view

Phenotypes for DTX3L Gene

genes like me logo Genes that share phenotypes with DTX3L: view

miRNA for DTX3L Gene

miRTarBase miRNAs that target DTX3L

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DTX3L Gene

Localization for DTX3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX3L Gene

Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTX3L Gene COMPARTMENTS Subcellular localization image for DTX3L gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DTX3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16809771
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with DTX3L: view

Pathways for DTX3L Gene

genes like me logo Genes that share pathways with DTX3L: view

Pathways by source for DTX3L Gene

UniProtKB/Swiss-Prot Q8TDB6-DTX3L_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DTX3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair IMP 23230272
GO:0006974 cellular response to DNA damage stimulus IMP 19818714
GO:0010390 histone monoubiquitination IDA 19818714
genes like me logo Genes that share ontologies with DTX3L: view

Transcripts for DTX3L Gene

mRNA/cDNA for DTX3L Gene

Unigene Clusters for DTX3L Gene

Deltex 3-like (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTX3L Gene

No ASD Table

Relevant External Links for DTX3L Gene

GeneLoc Exon Structure for
DTX3L
ECgene alternative splicing isoforms for
DTX3L

Expression for DTX3L Gene

mRNA expression in normal human tissues for DTX3L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DTX3L Gene

SOURCE GeneReport for Unigene cluster for DTX3L Gene Hs.518201

genes like me logo Genes that share expressions with DTX3L: view

Orthologs for DTX3L Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTX3L 36
  • 99.59 (n)
  • 99.19 (a)
DTX3L 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DTX3L 36
  • 78.58 (n)
  • 65.21 (a)
DTX3L 37
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DTX3L 36
  • 77.95 (n)
  • 66.71 (a)
DTX3L 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtx3l 36
  • 70.52 (n)
  • 60.33 (a)
Dtx3l 16
Dtx3l 37
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DTX3L 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTX3L 37
  • 31 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtx3l 36
  • 72.56 (n)
  • 63.11 (a)
chicken
(Gallus gallus)
Aves DTX3L 36
  • 52.89 (n)
  • 39.63 (a)
DTX3L 37
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTX3L 37
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DTX3L 37
  • 20 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dx 37
  • 17 (a)
OneToMany
Species with no ortholog for DTX3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX3L Gene

ENSEMBL:
Gene Tree for DTX3L (if available)
TreeFam:
Gene Tree for DTX3L (if available)

Paralogs for DTX3L Gene

Paralogs for DTX3L Gene

Selected SIMAP similar genes for DTX3L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DTX3L: view

Variants for DTX3L Gene

Sequence variations from dbSNP and Humsavar for DTX3L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7071 -- 122,574,926(-) TTTTT(A/T)AAAAA utr-variant-3-prime
rs1045089 -- 122,574,362(+) TTAAA(C/T)GGTTC utr-variant-3-prime
rs2036342 -- 122,571,732(+) AAAGC(C/T)AAAGG reference, synonymous-codon
rs2332285 - 122,569,363(+) GGACA(A/G)GCAGG missense, reference
rs4678198 -- 122,572,165(+) GCCTC(A/G)GCCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DTX3L Gene

Variant ID Type Subtype PubMed ID
nsv877391 CNV Gain 21882294
esv2672720 CNV Deletion 23128226

Relevant External Links for DTX3L Gene

HapMap Linkage Disequilibrium report
DTX3L

Disorders for DTX3L Gene

No disorders were found for DTX3L Gene.

No data available for UniProtKB/Swiss-Prot for DTX3L Gene

Publications for DTX3L Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K. … Shipp M.A. (J. Biol. Chem. 2003) 2 3 4 23
  2. Fold of the conserved DTC domain in deltex proteins. (PMID: 22411408) Obiero J. … Dhe-Paganon S. (Proteins 2012) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. (PMID: 16809771) Juszczynski P. … Shipp M.A. (Mol. Cell. Biol. 2006) 3 4

Products for DTX3L Gene

  • Addgene plasmids for DTX3L

Sources for DTX3L Gene

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