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Aliases for DTX3 Gene

Aliases for DTX3 Gene

  • Deltex E3 Ubiquitin Ligase 3 2 3 5
  • RING-Type E3 Ubiquitin Transferase DTX3 3 4
  • RING Finger Protein 154 3 4
  • Protein Deltex-3 3 4
  • Deltex3 3 4
  • RNF154 3 4
  • Probable E3 Ubiquitin-Protein Ligase DTX3 3
  • Deltex 3 Homolog (Drosophila) 2
  • Deltex Homolog 3 (Drosophila) 2
  • Deltex 3, E3 Ubiquitin Ligase 3
  • Deltex Homolog 3 3
  • EC 2.3.2.27 4

External Ids for DTX3 Gene

Previous GeneCards Identifiers for DTX3 Gene

  • GC12P056284
  • GC12P057998
  • GC12P055036

Summaries for DTX3 Gene

Entrez Gene Summary for DTX3 Gene

  • DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

GeneCards Summary for DTX3 Gene

DTX3 (Deltex E3 Ubiquitin Ligase 3) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG) and Notch Signaling Pathway (sino). GO annotations related to this gene include ligase activity. An important paralog of this gene is DTX3L.

UniProtKB/Swiss-Prot for DTX3 Gene

  • Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Additional gene information for DTX3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX3 Gene

Genomics for DTX3 Gene

Regulatory Elements for DTX3 Gene

Enhancers for DTX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H057109 1.5 ENCODE dbSUPER 91 -493.1 -493074 3 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 MCM3 MEF2D SSRP1 NEMP1 BAZ2A EEF1AKMT3 ENSG00000257740 SMARCC2 CDK4 CTDSP2 PAN2 ANKRD52 DTX3
GH12H057245 1.2 ENCODE dbSUPER 36.2 -359.1 -359095 0 PKNOX1 ZNF2 ATF7 YY2 REST ZNF662 ZNF491 ZNF518A ZNF610 GLIS1 ENSG00000257740 DTX3 NEMP1 PAN2 LOC283387 ANKRD52 ENSG00000224713 NAB2 EEF1AKMT3 ZBTB39
GH12H057516 1.4 ENCODE dbSUPER 26.1 -83.2 -83239 8 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 MEF2D NEMP1 BAZ2A RN7SL809P DTX3 ZBTB39 MBD6 ENSG00000224713 CTDSP2 EEF1AKMT3 DCTN2
GH12H056631 1.4 ENCODE dbSUPER 16.8 -969.4 -969408 6 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ENSG00000224713 BAZ2A IKZF4 NEMP1 SMARCC2 DTX3 ENSG00000257740 ZC3H10 ARHGEF25 PAN2
GH12H057207 0.7 dbSUPER 33.1 -395.6 -395560 2 ZBTB21 ZNF140 ZNF266 ZNF697 ZNF121 ZNF791 ZNF547 KLF7 ZNF433 ZNF202 NEMP1 BAZ2A PAN2 EEF1AKMT3 ZBTB39 CDK4 DTX3 CTDSP2 RN7SL809P TSPAN31
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DTX3 on UCSC Golden Path with GeneCards custom track

Promoters for DTX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052688 573 1001 MXI1 ZBTB21 ZNF223 ZNF76 RFX5 YY1 ZFHX2 POLR2A PATZ1 SCRT2

Genomic Location for DTX3 Gene

Chromosome:
12
Start:
57,604,327 bp from pter
End:
57,609,804 bp from pter
Size:
5,478 bases
Orientation:
Plus strand

Genomic View for DTX3 Gene

Genes around DTX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX3 Gene

Proteins for DTX3 Gene

  • Protein details for DTX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9I9-DTX3_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase DTX3
    Protein Accession:
    Q8N9I9
    Secondary Accessions:
    • Q53ZZ2
    • Q8NAU6
    • Q8NDS8

    Protein attributes for DTX3 Gene

    Size:
    347 amino acids
    Molecular mass:
    37988 Da
    Quaternary structure:
    • Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1.
    SequenceCaution:
    • Sequence=CAD38593.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for DTX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX3 Gene

Post-translational modifications for DTX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DTX3 Gene

Domains & Families for DTX3 Gene

Gene Families for DTX3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DTX3 Gene

Suggested Antigen Peptide Sequences for DTX3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N9I9

UniProtKB/Swiss-Prot:

DTX3_HUMAN :
  • Belongs to the Deltex family.
Family:
  • Belongs to the Deltex family.
genes like me logo Genes that share domains with DTX3: view

Function for DTX3 Gene

Molecular function for DTX3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Enzyme Numbers (IUBMB) for DTX3 Gene

Phenotypes From GWAS Catalog for DTX3 Gene

Gene Ontology (GO) - Molecular Function for DTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19549727
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DTX3: view
genes like me logo Genes that share phenotypes with DTX3: view

Animal Model Products

CRISPR Products

miRNA for DTX3 Gene

miRTarBase miRNAs that target DTX3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DTX3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTX3 Gene

Localization for DTX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTX3 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DTX3: view

Pathways & Interactions for DTX3 Gene

genes like me logo Genes that share pathways with DTX3: view

Pathways by source for DTX3 Gene

1 Sino Biological pathway for DTX3 Gene
1 GeneTex pathway for DTX3 Gene
1 BioSystems pathway for DTX3 Gene
1 KEGG pathway for DTX3 Gene

UniProtKB/Swiss-Prot Q8N9I9-DTX3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DTX3: view

No data available for SIGNOR curated interactions for DTX3 Gene

Drugs & Compounds for DTX3 Gene

No Compound Related Data Available

Transcripts for DTX3 Gene

Unigene Clusters for DTX3 Gene

Deltex homolog 3 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DTX3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DTX3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: - -
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for DTX3 Gene

GeneLoc Exon Structure for
DTX3
ECgene alternative splicing isoforms for
DTX3

Expression for DTX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DTX3 Gene

This gene is overexpressed in Retina (12.8), Rectum (11.2), Fetal Brain (8.6), and Stomach (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DTX3 Gene



Protein tissue co-expression partners for DTX3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DTX3 Gene:

DTX3

SOURCE GeneReport for Unigene cluster for DTX3 Gene:

Hs.32374

Evidence on tissue expression from TISSUES for DTX3 Gene

  • Nervous system(4.7)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with DTX3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTX3 Gene

Orthologs for DTX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTX3 33 34
  • 97.08 (n)
cow
(Bos Taurus)
Mammalia DTX3 33 34
  • 92.32 (n)
dog
(Canis familiaris)
Mammalia DTX3 33 34
  • 91.24 (n)
rat
(Rattus norvegicus)
Mammalia Dtx3 33
  • 90.97 (n)
mouse
(Mus musculus)
Mammalia Dtx3 33 16 34
  • 90.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DTX3 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia DTX3 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtx3 33
  • 68.43 (n)
Str.17194 33
zebrafish
(Danio rerio)
Actinopterygii zgc:66440 33
  • 59.18 (n)
DTX3 34
  • 42 (a)
OneToOne
zgc66440 33
fruit fly
(Drosophila melanogaster)
Insecta dx 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
Species where no ortholog for DTX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX3 Gene

ENSEMBL:
Gene Tree for DTX3 (if available)
TreeFam:
Gene Tree for DTX3 (if available)

Paralogs for DTX3 Gene

Paralogs for DTX3 Gene

(3) SIMAP similar genes for DTX3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DTX3: view

Variants for DTX3 Gene

Sequence variations from dbSNP and Humsavar for DTX3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000700275 -- 57,607,160(+) AGGCA(C/G)GGGGA reference, missense
rs1001378807 -- 57,610,282(+) GGCAT(A/G)CTGCG downstream-variant-500B, upstream-variant-2KB, reference, missense
rs1001638897 -- 57,603,538(+) CCCTA(A/C)CTAAG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001900918 -- 57,605,200(+) CCCCC(A/G)GGGAC intron-variant, utr-variant-5-prime
rs1002192094 -- 57,606,510(+) TCTTC(A/G)GGATC reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DTX3 Gene

Variant ID Type Subtype PubMed ID
esv2759901 CNV gain 17122850
nsv428283 CNV gain 18775914
nsv482992 CNV gain+loss 15286789
nsv559034 CNV loss 21841781

Variation tolerance for DTX3 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX3 Gene

Disorders for DTX3 Gene

Relevant External Links for DTX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTX3

No disorders were found for DTX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTX3 Gene

Publications for DTX3 Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K … Shipp MA (The Journal of biological chemistry 2003) 2 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for DTX3 Gene

Sources for DTX3 Gene

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