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DTX3 Gene

protein-coding   GIFtS: 52
GCID: GC12P057998

Deltex 3, E3 Ubiquitin Ligase

(Previous names: deltex 3 homolog (Drosophila), deltex homolog 3 (Drosophila))
  Search for DTX3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Deltex 3, E3 Ubiquitin Ligase1 2     Deltex Homolog 32
Protein Deltex-32 3     deltex32
RNF1542 3     Probable E3 Ubiquitin-Protein Ligase DTX32
RING Finger Protein 1542 3     Deltex33
Deltex 3 Homolog (Drosophila)1     EC 6.3.2.-3
Deltex Homolog 3 (Drosophila)1     

External Ids:    HGNC: 244571   Entrez Gene: 1964032   Ensembl: ENSG000001784987   OMIM: 6131425   UniProtKB: Q8N9I93   
ORGUL members:         

Export aliases for DTX3 gene to outside databases

Previous GC identifers: GC12P056284 GC12P055036


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DTX3 Gene:
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)).(supplied by OMIM, Nov 2009)

GeneCards Summary for DTX3 Gene:
DTX3 (deltex 3, E3 ubiquitin ligase) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is DTX1.

UniProtKB/Swiss-Prot: DTX3_HUMAN, Q8N9I9
Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a
broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch,
depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in
vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DTX3 gene promoter:
         Tal-1   IRF-1   AP-4   NF-kappaB   Tal-1beta   E47   RORalpha1   Pax-3   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDTX3 promoter sequence
   Search Chromatin IP Primers for DTX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.2

DTX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTX3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057998:  view genomic region     (about GC identifiers)

Start:
57,998,405 bp from pter      End:
58,003,587 bp from pter
Size:
5,183 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DTX3_HUMAN, Q8N9I9 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase DTX3  
Size: 347 amino acids; 37988 Da
Subunit: Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1 (By
similarity)
Sequence caution: Sequence=CAD38593.2; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: Q53ZZ2 Q8NAU6 Q8NDS8
Alternative splicing: 2 isoforms:  Q8N9I9-1   Q8N9I9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DTX3: NX_Q8N9I9

Explore proteomics data for DTX3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DTX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273174.1  NP_001273175.1  NP_848597.1  

    ENSEMBL proteins: 
     ENSP00000449294   ENSP00000449118   ENSP00000449950   ENSP00000449688   ENSP00000338050  
     ENSP00000447873   ENSP00000448696   ENSP00000448224   ENSP00000446996  

    DTX3 Human Recombinant Protein Products:

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    Novus Biologicals DTX3 Protein
    Novus Biologicals DTX3 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DTX3

     
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    LSBio Antibodies in human, mouse, rat for DTX3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8N9I9

    ProtoNet protein and cluster: Q8N9I9

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: DTX3_HUMAN, Q8N9I9
    Similarity: Belongs to the Deltex family
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with DTX3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DTX3_HUMAN, Q8N9I9
    Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a
    broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch,
    depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in
    vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with DTX3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for DTX3:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DTX3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DTX3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DTX3

    miRNA
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    miRTarBase miRNAs that target DTX3:
    hsa-mir-320a (MIRT044416)

    Block miRNA regulation of human, mouse, rat DTX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DTX3 (see all 10):
    hsa-miR-3173-3p hsa-miR-448 hsa-miR-4271 hsa-miR-622 hsa-miR-548v hsa-miR-139-5p hsa-miR-4306 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidDTX3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DTX3

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DTX3 (NM_138287)
    Sino Biological Human cDNA Clone for DTX3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DTX3_HUMAN, Q8N9I9: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DTX3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DTX3 About    
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84


    Find genes that share SuperPaths with DTX3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DTX3
        Notch Signaling Pathway



    1 Kegg Pathway  (Kegg details for DTX3):
        Notch signaling pathway

    UniProtKB/Swiss-Prot: DTX3_HUMAN, Q8N9I9
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including DTX3: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DTX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DTX3 (Q8N9I93 ENSP000003380504) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2L6O149333, ENSP000002871564I2D: score=2 STRING: ENSP00000287156
    UBE2V1Q134043, ENSP000003403054I2D: score=2 STRING: ENSP00000340305
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway IEA--
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with DTX3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DTX3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DTX3 gene (3 alternative transcripts): 
    NM_001286245.1  NM_001286246.1  NM_178502.3  

    Unigene Cluster for DTX3:

    Deltex homolog 3 (Drosophila)
    Hs.32374  [show with all ESTs]
    Unigene Representative Sequence: AL831941
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548804 ENST00000550596 ENST00000551835 ENST00000549583 ENST00000337737(uc001sow.1 uc001sox.1)
    ENST00000548198(uc001sov.1 uc001soy.1) ENST00000551632 ENST00000548478
    ENST00000550300
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DTX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DTX3 (see all 10):
    hsa-miR-3173-3p hsa-miR-448 hsa-miR-4271 hsa-miR-622 hsa-miR-548v hsa-miR-139-5p hsa-miR-4306 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidDTX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DTX3
    Predesigned siRNA for gene silencing in human, mouse, rat DTX3
    Clone
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    OriGene clones in human, mouse for DTX3 (see all 6)
    OriGene ORF clones in mouse, rat for DTX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DTX3 (NM_138287)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX3
    Primer
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    OriGene qPCR primer pairs and template standards for DTX3
    OriGene qSTAR qPCR primer pairs in human, mouse for DTX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTX3
      QuantiTect SYBR Green Assays in human, mouse, rat DTX3
      QuantiFast Probe-based Assays in human, mouse, rat DTX3

    Additional mRNA sequence: 

    AK092085.1 AK094385.1 AL831941.1 AY225126.1 BC035831.1 BC114441.1 BC114498.1 

    13 DOTS entries:

    DT.307909  DT.97779508  DT.100775026  DT.97840707  DT.448678  DT.95272160  DT.121125578  DT.121125598 
    DT.121125594  DT.91694202  DT.97825454  DT.91986402  DT.95272161 

    Selected AceView cDNA sequences (see all 210):

    AI222166 BE551883 N42852 AL831941 CA865625 AY225126 H30680 AK092085 
    BF508540 BU790035 AI382672 AI224573 BF115533 BM314583 AI031895 BF508038 
    AW054832 AW517855 BG222952 AI338184 BF195613 BQ271298 AI672665 CA776637 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DTX3 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7a · 7b ^ 8 ^ 9
    SP1:              -     -                                                                                                   
    SP2:              -           -     -                                                                                       
    SP3:              -     -     -     -                                                                                       
    SP4:              -     -     -     -                       -                                                               
    SP5:                          -     -                                                                                       


    ECgene alternative splicing isoforms for DTX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DTX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCGGCTG
    DTX3 Expression
    About this image


    DTX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
     
     Ovary (Reproductive System)
    DTX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DTX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32374
        Pathway & Disease-focused RT2 Profiler PCR Array including DTX3: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DTX3
    OriGene qSTAR qPCR primer pairs in human, mouse for DTX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTX3
    QuantiTect SYBR Green Assays in human, mouse, rat DTX3
    QuantiFast Probe-based Assays in human, mouse, rat DTX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DTX3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtx31 , 5 deltex 3 homolog (Drosophila)1, 5 90.11(n)1
    97.12(a)1
      10 (74.50 cM)5
    809041  NM_030714.21  NP_109639.11 
     1271903785 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    24(a)
    many ↔ many
    27(5109324-5111363)
    lizard
    (Anolis carolinensis)
    Reptilia DTX36
    deltex homolog 3 (Drosophila)
    76(a)
    1 ↔ 1
    GL343212.1(250893-264063)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171942 Transcribed sequence with weak similarity to protein more 77.24(n)    142022230 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc664402 hypothetical protein MGC66440 73.31(n)   393500  BC055658.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dx6
    deltex
    13(a)
    1 → many
    X(6428043-6432615)


    ENSEMBL Gene Tree for DTX3 (if available)
    TreeFam Gene Tree for DTX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DTX3 gene
    DTX12  DTX42  DTX3L2  DTX22  
    3 SIMAP similar genes for DTX3 using alignment to 4 protein entries:     DTX3_HUMAN (see all proteins):
    DTX4    DTX3L    DTX2

    Find genes that share paralogs with DTX3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DTX3 (see all 102)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884302831,2
    --57997713(+) TTGGGA/GGATTC 1 -- us2k10--------
    rs122967871,2
    H--57997736(+) GCTGAG/AGAAGT 1 -- us2k14Minor allele frequency- A:0.00NS EA 374
    rs1455885131,2
    --57997748(+) TTTTGC/GCTGGT 1 -- us2k10--------
    rs1140315081,2
    C,F--57997777(+) GTGGCC/TCCAGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs733460851,2
    C,F--57997869(+) ACTCTG/ATTTGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs743285951,2
    C,F--57998311(+) GGAGCG/CGGGAG 1 -- us2k11Minor allele frequency- C:0.07EA 120
    rs740936371,2
    C,F--57998364(+) GTTCCC/ATGACG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1150117141,2
    F--57998418(+) TTTTGG/AGGAGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1812298231,2
    --57998480(+) CTGTGA/GGGGGA 1 -- us2k10--------
    rs714613301,2
    C,F--57998722(+) TCCCCC/TGGCGC 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for DTX3 (57998405 - 58003587 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DTX3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428283CNV Gain18775914
    dgv513e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613142    OMIM disorders: --


    Find genes that share disorders with DTX3           About GenesLikeMe


    Export disorders for DTX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DTX3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with DTX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PubMed id 12670957)1, 2, 3, 9 Takeyama K.... Shipp M.A. (J. Biol. Chem. 2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    5. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)
    6. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Itch/AIP4 mediates Deltex degradation through the formation of K29- linked polyubiquitin chains. (PubMed id 17028573)1 Chastagner P.... Brou C. (EMBO Rep. 2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 196403 HGNC: 24457 AceView: DTX3 Ensembl:ENSG00000178498 euGenes: HUgn196403
    ECgene: DTX3 Kegg: 196403 H-InvDB: DTX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DTX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DTX3 gene:
    Search GeneIP for patents involving DTX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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