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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DTX3 Gene

protein-coding   GIFtS: 50
GCID: GC12P057998

Deltex Homolog 3 (Drosophila)

(Previous name: deltex 3 homolog (Drosophila))
  Search for DTX3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Deltex Homolog 3 (Drosophila)1 2     Deltex 3 Homolog2
Protein Deltex-32 3     deltex32
RNF1542 3     Probable E3 Ubiquitin-Protein Ligase DTX32
RING Finger Protein 1542 3     Deltex33
Deltex 3 Homolog (Drosophila)1     EC 6.3.2.-3

External Ids:    HGNC: 244571   Entrez Gene: 1964032   Ensembl: ENSG000001784987   OMIM: 6131425   UniProtKB: Q8N9I93   

Export aliases for DTX3 gene to outside databases

Previous GC identifers: GC12P056284 GC12P055036


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DTX3 Gene:
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)).(supplied by OMIM, Nov 2009)

GeneCards Summary for DTX3 Gene: 
DTX3 (deltex homolog 3 (Drosophila)) is a protein-coding gene. Among its related super-pathways are Notch Signaling Pathway. GO annotations related to this gene include zinc ion binding and ligase activity. An important paralog of this gene is DTX1.

UniProtKB/Swiss-Prot: DTX3_HUMAN, Q8N9I9
Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a
broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch,
depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in
vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DTX3 gene promoter:
         Tal-1   IRF-1   AP-4   NF-kappaB   Tal-1beta   E47   RORalpha1   Pax-3   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDTX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DTX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.2

DTX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTX3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057998:  view genomic region     (about GC identifiers)

Start:
57,998,405 bp from pter      End:
58,003,587 bp from pter
Size:
5,183 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DTX3_HUMAN, Q8N9I9 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase DTX3  
Size: 347 amino acids; 37988 Da
Subunit: Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1 (By
similarity)
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=CAD38593.2; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: Q53ZZ2 Q8NAU6 Q8NDS8
Alternative splicing: 2 isoforms:  Q8N9I9-1   Q8N9I9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DTX3: NX_Q8N9I9

Explore proteomics data for DTX3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N9I9

  • DTX3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DTX3 Protein Expression
    REFSEQ proteins: NP_848597.1  
    ENSEMBL proteins: 
     ENSP00000449294   ENSP00000449118   ENSP00000449950   ENSP00000449688   ENSP00000338050  
     ENSP00000447873   ENSP00000448696   ENSP00000448224   ENSP00000446996  

    Human Recombinant Protein Products for DTX3: 
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    OriGene Protein Over-expression Lysate for DTX3
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    Novus Biologicals DTX3 Protein
    Novus Biologicals DTX3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DTX3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    DTX3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for DTX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8N9I9

    ProtoNet protein and cluster: Q8N9I9

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: DTX3_HUMAN, Q8N9I9
    Similarity: Belongs to the Deltex family
    Similarity: Contains 1 RING-type zinc finger


    DTX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DTX3_HUMAN, Q8N9I9
    Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a
    broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch,
    depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in
    vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    DTX3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DTX3:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DTX3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DTX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DTX3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DTX3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DTX3
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate DTX3 (see all 10):
    hsa-miR-3173-3p hsa-miR-448 hsa-miR-4271 hsa-miR-622 hsa-miR-548v hsa-miR-139-5p hsa-miR-4306 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidDTX3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for DTX3
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DTX3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DTX3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DTX3
        Notch Signaling Pathway



    1         Kegg Pathway  (Kegg details for DTX3):
        Notch signaling pathway

    UniProtKB/Swiss-Prot: DTX3_HUMAN, Q8N9I9
    Pathway: Protein modification; protein ubiquitination


    DTX3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DTX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/27 Interacting proteins for DTX3 (Q8N9I93 ENSP000003380504) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2L6O149333, ENSP000002871564I2D: score=2 STRING: ENSP00000287156
    UBE2V1Q134043, ENSP000003403054I2D: score=2 STRING: ENSP00000340305
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway IEA--
    GO:0016567protein ubiquitination IEA--

    DTX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DTX3

    Search CenterWatch for drugs/clinical trials and news about DTX3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DTX3 gene: 
    NM_178502.2  

    Unigene Cluster for DTX3:

    Deltex homolog 3 (Drosophila)
    Hs.32374  [show with all ESTs]
    Unigene Representative Sequence: AL831941
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548804 ENST00000550596 ENST00000551835 ENST00000549583 ENST00000337737(uc001sow.1 uc001sox.1)
    ENST00000548198(uc001sov.1 uc001soy.1) ENST00000551632 ENST00000548478
    ENST00000550300
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate DTX3 (see all 10):
    hsa-miR-3173-3p hsa-miR-448 hsa-miR-4271 hsa-miR-622 hsa-miR-548v hsa-miR-139-5p hsa-miR-4306 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidDTX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DTX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTX3
    Clone
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    OriGene clones in human, mouse for DTX3 (see all 7)
    OriGene ORF clones in mouse, rat for DTX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DTX3 (NM_138287)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX3
    Sirion Biotech Customized lentivirus for stable overexpression of DTX3 
                         Customized lentivirus expression plasmids for stable overexpression of DTX3 
    Primer
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    OriGene qPCR primer pairs and template standards for DTX3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTX3

    Additional mRNA sequence: 

    AK092085.1 AK094385.1 AL831941.1 AY225126.1 BC035831.1 BC114441.1 BC114498.1 

    13 DOTS entries:

    DT.307909  DT.97779508  DT.100775026  DT.97840707  DT.448678  DT.95272160  DT.121125578  DT.121125598 
    DT.121125594  DT.91694202  DT.97825454  DT.91986402  DT.95272161 

    24/210 AceView cDNA sequences (see all 210):

    BI770075 BI761143 AW574818 BU071933 CA776637 AI264526 BG222952 BE551883 
    BM708735 CA868429 CA865625 H30680 AK092085 AI652097 AW517855 AI031895 
    BM314583 AI262649 AI569820 AY225126 AI224573 AW058006 AI286231 AI351594 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DTX3 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7a · 7b ^ 8 ^ 9
    SP1:              -     -                                                                                                   
    SP2:              -           -     -                                                                                       
    SP3:              -     -     -     -                                                                                       
    SP4:              -     -     -     -                       -                                                               
    SP5:                          -     -                                                                                       


    ECgene alternative splicing isoforms for DTX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DTX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCGGCTG
    DTX3 Expression
    About this image


    See DTX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DTX3

    SOURCE GeneReport for Unigene cluster: Hs.32374
        SABiosciences Expression via Pathway-Focused PCR Array including DTX3: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DTX3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtx31 , 5 deltex 3 homolog (Drosophila)1, 5 91.45(n)1
    98.56(a)1
      10 (74.50 cM)5
    809041  NM_030714.21  NP_109639.11 
     1271903785 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    23(a)
    possible ortholog
    27(5109324-5111363)
    lizard
    (Anolis carolinensis)
    Reptilia DTX36
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343212.1(250893-264063)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171942 Transcribed sequence with weak similarity to protein more 77.24(n)    142022230 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc664402 hypothetical protein MGC66440 73.31(n)   393500  BC055658.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dx6
    deltex
    13(a)
    1 → many
    X(6428043-6432615)


    ENSEMBL Gene Tree for DTX3 (if available)
    TreeFam Gene Tree for DTX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DTX3 gene
    DTX12  DTX42  DTX3L2  DTX22  
    3 SIMAP similar genes for DTX3 using alignment to 4 protein entries:     DTX3_HUMAN (see all proteins):
    DTX4    DTX3L    DTX2

    DTX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/102 SNPs in DTX3 are shown (see all 102)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884302831,2
    --57997713(+) TTGGGA/GGATTC 1 -- us2k10--------
    rs122967871,2
    H--57997736(+) GCTGAG/AGAAGT 1 -- us2k14Minor allele frequency- A:0.00NS EA 374
    rs1455885131,2
    --57997748(+) TTTTGC/GCTGGT 1 -- us2k10--------
    rs1140315081,2
    C,F--57997777(+) GTGGCC/TCCAGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs733460851,2
    C,F--57997869(+) ACTCTG/ATTTGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs743285951,2
    C,F--57998311(+) GGAGCG/CGGGAG 1 -- us2k11Minor allele frequency- C:0.07EA 120
    rs740936371,2
    C,F--57998364(+) GTTCCC/ATGACG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1150117141,2
    F--57998418(+) TTTTGG/AGGAGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1812298231,2
    --57998480(+) CTGTGA/GGGGGA 1 -- us2k10--------
    rs714613301,2
    C,F--57998722(+) TCCCCC/TGGCGC 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for DTX3 (57998405 - 58003587 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DTX3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428283CNV Gain18775914
    dgv513e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DTX3 for disorders           About MalaCards
    OMIM gene information: 613142    OMIM disorders: --


    DTX3 for disorders           About GeneDecksing


    Export disorders for DTX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DTX3 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with DTX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PubMed id 12670957)1, 2, 9 Takeyama K.... Shipp M.A. (2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (2013)
    4. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    5. Direct and indirect control of mitogen-activated prote in kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/R AF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....Urbe S. (2012)
    6. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. (PubMed id 17028573)1 Chastagner P....Brou C. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 196403 HGNC: 24457 AceView: DTX3 Ensembl:ENSG00000178498 euGenes: HUgn196403
    ECgene: DTX3 Kegg: 196403 H-InvDB: DTX3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DTX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DTX3 gene:
    Search GeneIP for patents involving DTX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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