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Aliases for DTX3 Gene

Aliases for DTX3 Gene

  • Deltex 3, E3 Ubiquitin Ligase 2 3
  • RING Finger Protein 154 3 4
  • Protein Deltex-3 3 4
  • Deltex3 3 4
  • RNF154 3 4
  • Probable E3 Ubiquitin-Protein Ligase DTX3 3
  • Deltex 3 Homolog (Drosophila) 2
  • Deltex Homolog 3 (Drosophila) 2
  • Deltex Homolog 3 3
  • EC 6.3.2.- 4

External Ids for DTX3 Gene

Previous GeneCards Identifiers for DTX3 Gene

  • GC12P056284
  • GC12P057998
  • GC12P055036

Summaries for DTX3 Gene

Entrez Gene Summary for DTX3 Gene

  • DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

GeneCards Summary for DTX3 Gene

DTX3 (Deltex 3, E3 Ubiquitin Ligase) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG) and Notch signaling pathway (KEGG). GO annotations related to this gene include ligase activity. An important paralog of this gene is DTX4.

UniProtKB/Swiss-Prot for DTX3 Gene

  • Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX3 Gene

Genomics for DTX3 Gene

Regulatory Elements for DTX3 Gene

Genomic Location for DTX3 Gene

Start:
57,604,327 bp from pter
End:
57,609,804 bp from pter
Size:
5,478 bases
Orientation:
Plus strand

Genomic View for DTX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX3 Gene

Proteins for DTX3 Gene

  • Protein details for DTX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9I9-DTX3_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase DTX3
    Protein Accession:
    Q8N9I9
    Secondary Accessions:
    • Q53ZZ2
    • Q8NAU6
    • Q8NDS8

    Protein attributes for DTX3 Gene

    Size:
    347 amino acids
    Molecular mass:
    37988 Da
    Quaternary structure:
    • Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1 (By similarity).
    SequenceCaution:
    • Sequence=CAD38593.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for DTX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX3 Gene

Proteomics data for DTX3 Gene at MOPED

Post-translational modifications for DTX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DTX3 Gene

Domains for DTX3 Gene

Gene Families for DTX3 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for DTX3 Gene

Suggested Antigen Peptide Sequences for DTX3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N9I9

UniProtKB/Swiss-Prot:

DTX3_HUMAN :
  • Q8N9I9
Family:
  • Belongs to the Deltex family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with DTX3: view

Function for DTX3 Gene

Molecular function for DTX3 Gene

UniProtKB/Swiss-Prot Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Enzyme Numbers (IUBMB) for DTX3 Gene

Gene Ontology (GO) - Molecular Function for DTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with DTX3: view
genes like me logo Genes that share phenotypes with DTX3: view

miRNA for DTX3 Gene

miRTarBase miRNAs that target DTX3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DTX3 Gene

Localization for DTX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTX3 Gene COMPARTMENTS Subcellular localization image for DTX3 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DTX3: view

Pathways for DTX3 Gene

genes like me logo Genes that share pathways with DTX3: view

Pathways by source for DTX3 Gene

1 BioSystems pathway for DTX3 Gene
1 KEGG pathway for DTX3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q8N9I9-DTX3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DTX3: view

Transcripts for DTX3 Gene

Unigene Clusters for DTX3 Gene

Deltex homolog 3 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DTX3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTX3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: - -
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for DTX3 Gene

GeneLoc Exon Structure for
DTX3
ECgene alternative splicing isoforms for
DTX3

Expression for DTX3 Gene

mRNA expression in normal human tissues for DTX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DTX3 Gene

This gene is overexpressed in Retina (12.8), Rectum (11.2), Fetal Brain (8.6), and Stomach (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DTX3 Gene

SOURCE GeneReport for Unigene cluster for DTX3 Gene Hs.32374

genes like me logo Genes that share expressions with DTX3: view

Expression partners for DTX3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DTX3 Gene

Orthologs for DTX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DTX3 35
  • 92.32 (n)
  • 97.12 (a)
DTX3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DTX3 35
  • 91.24 (n)
  • 94.23 (a)
DTX3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtx3 35
  • 90.11 (n)
  • 97.12 (a)
Dtx3 16
Dtx3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DTX3 35
  • 97.08 (n)
  • 96.79 (a)
DTX3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtx3 35
  • 90.97 (n)
  • 97.12 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia DTX3 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia DTX3 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtx3 35
  • 68.43 (n)
  • 74.71 (a)
Str.17194 35
zebrafish
(Danio rerio)
Actinopterygii zgc66440 35
zgc:66440 35
  • 59.18 (n)
  • 55.06 (a)
DTX3 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dx 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for DTX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX3 Gene

ENSEMBL:
Gene Tree for DTX3 (if available)
TreeFam:
Gene Tree for DTX3 (if available)

Paralogs for DTX3 Gene

Paralogs for DTX3 Gene

Selected SIMAP similar genes for DTX3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DTX3: view

Variants for DTX3 Gene

Sequence variations from dbSNP and Humsavar for DTX3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs703834 -- 57,606,595(+) GGCAA(A/G)TTGTT intron-variant
rs755288 -- 57,606,413(+) TTTCT(C/T)ACTTT intron-variant
rs755289 -- 57,606,433(+) TTTCC(A/G)CCCTA intron-variant
rs775242 -- 57,605,763(+) GGGGC(A/T)GCTGC intron-variant
rs1806652 -- 57,605,318(-) GGCGG(A/G)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTX3 Gene

Variant ID Type Subtype PubMed ID
dgv513e1 CNV Complex 17122850
nsv428283 CNV Gain 18775914

Relevant External Links for DTX3 Gene

HapMap Linkage Disequilibrium report
DTX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX3 Gene

Disorders for DTX3 Gene

No disorders were found for DTX3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DTX3 Gene

Publications for DTX3 Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K. … Shipp M.A. (J. Biol. Chem. 2003) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Itch/AIP4 mediates Deltex degradation through the formation of K29- linked polyubiquitin chains. (PMID: 17028573) Chastagner P. … Brou C. (EMBO Rep. 2006) 3
  5. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G. … Sanderson C.M. (Genome Res. 2009) 3

Products for DTX3 Gene

Sources for DTX3 Gene

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