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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DTX2 Gene

protein-coding   GIFtS: 57
GCID: GC07P076090

Deltex Homolog 2 (Drosophila)

(Previous name: deltex (Drosophila) homolog 2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Deltex Homolog 2 (Drosophila)1 2     Deltex (Drosophila) Homolog 21
Protein Deltex-22 3     deltex22
RING Finger Protein 582 3     Probable E3 Ubiquitin-Protein Ligase DTX22
RNF582 3     Zinc Ion Binding Protein2
hDTX22 3     Deltex23
KIAA15283 5     EC 6.3.2.-3

External Ids:    HGNC: 159731   Entrez Gene: 1138782   Ensembl: ENSG000000910737   OMIM: 6131415   UniProtKB: Q86UW93   

Export aliases for DTX2 gene to outside databases

Previous GC identifers: GC07P074626 GC07P075689 GC07P075703 GC07P075735 GC07P075928 GC07P071168


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DTX2 Gene:
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)).(supplied by OMIM, Nov 2009)

GeneCards Summary for DTX2 Gene: 
DTX2 (deltex homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with DTX2 include pthirus pubis infestation, and among its related super-pathways are Notch Signaling Pathway and Constitutive Signaling by NOTCH1 PEST Domain Mutants. GO annotations related to this gene include zinc ion binding and ligase activity. An important paralog of this gene is DTX1.

UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9
Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a
broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch,
depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by
inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro,
suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity

Gene Wiki entry for DTX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DTX2 gene promoter:
         Max1   GATA-3   HOXA5   AP-4   Evi-1   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): DTX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DTX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

DTX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTX2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P076090:  view genomic region     (about GC identifiers)

Start:
76,090,972 bp from pter      End:
76,135,312 bp from pter
Size:
44,341 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 75,424,036-75,468,376     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase DTX2  
Size: 622 amino acids; 67246 Da
Subunit: Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 (By
similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear
Sequence caution: Sequence=BAA96052.1; Type=Erroneous initiation;
Secondary accessions: Q6XM87 Q6XM88 Q96H69 Q9H890 Q9P200
Alternative splicing: 2 isoforms:  Q86UW9-1   Q86UW9-2   

Explore the universe of human proteins at neXtProt for DTX2: NX_Q86UW9

Explore proteomics data for DTX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UW9

  • DTX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DTX2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001096064.1  NP_001096065.1  NP_001096066.1  NP_065943.2  

    ENSEMBL proteins: 
     ENSP00000407398   ENSP00000409040   ENSP00000389231   ENSP00000322885   ENSP00000390881  
     ENSP00000397648   ENSP00000390218   ENSP00000415838   ENSP00000387894   ENSP00000411986  
     ENSP00000392114   ENSP00000403342   ENSP00000399639   ENSP00000392545   ENSP00000410892  
     ENSP00000305242  
    Reactome Protein details: Q86UW9
    Human Recombinant Protein Products for DTX2: 
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    Novus Biologicals DTX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DTX2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0031965nuclear membrane IDA--

    DTX2 for ontologies           About GeneDecksing



    DTX2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DTX2 

    Assay Products for DTX2: 
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    Cloud-Clone Corp. ELISAs for DTX2 
    Cloud-Clone Corp. CLIAs for DTX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR004170 WWE-dom
     IPR018123 WWE-dom_subgr
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q86UW9

    ProtoNet protein and cluster: Q86UW9

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9
    Domain: The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in
    ubiquitin ligases (By similarity)
    Similarity: Belongs to the Deltex family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 WWE domains


    DTX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DTX2_HUMAN, Q86UW9
    Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a
    broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch,
    depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by
    inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro,
    suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    DTX2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DTX2:
     Decreased Wnt reporter activit  Increased Salmonella enterica   Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dtx2):
     immune system 

    DTX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dtx2tm1Mjb for DTX2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DTX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DTX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DTX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DTX2 

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DTX2 (see all 19):
    hsa-miR-137 hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidDTX2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DTX2
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    GenScript: all cDNA clones in your preferred vector (see all 4): DTX2 (NM_001102596)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX2
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DTX2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84
    2Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH0.74
    3NOTCH2 intracellular domain regulates transcription
    Activated NOTCH1 Transmits Signal to the Nucleus0.59
    4Signaling by GPCR
    Signal Transduction0.55
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for DTX2
        Wnt / Hedgehog / Notch
    Protein Stability

    1 BioSystems Pathway for DTX2
        Notch Signaling Pathway

    5/11        Reactome Pathways for DTX2 (see all 11)
        Signaling by NOTCH
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer
    Disease


    1         Kegg Pathway  (Kegg details for DTX2):
        Notch signaling pathway

    UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9
    Pathway: Protein modification; protein ubiquitination


    DTX2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DTX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/27 Interacting proteins for DTX2 (Q86UW91, 2, 3 ENSP000003228854) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCALDP616012, 3, ENSP000002209314MINT-67559 I2D: score=5 STRING: ENSP00000220931
    HPCAL4Q9UM192, 3, ENSP000003619354MINT-66565 I2D: score=4 STRING: ENSP00000361935
    RBPMSQ930622, 3, ENSP000003401764MINT-66077 I2D: score=4 STRING: ENSP00000340176
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66536 I2D: score=4 STRING: ENSP00000360441
    VSNL1P627602, 3, ENSP000002951564MINT-66129 I2D: score=4 STRING: ENSP00000295156
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway IEA--
    GO:0016567protein ubiquitination IEA--

    DTX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DTX2

    Search CenterWatch for drugs/clinical trials and news about DTX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DTX2 gene (4 alternative transcripts): 
    NM_001102594.1  NM_001102595.1  NM_001102596.1  NM_020892.2  

    Unigene Cluster for DTX2:

    Deltex homolog 2 (Drosophila)
    Hs.187058  [show with all ESTs]
    Unigene Representative Sequence: NM_020892
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000425780 ENST00000456590 ENST00000451769 ENST00000324432(uc011kgk.1 uc003uff.4 uc003ufg.4 uc003ufh.4)
    ENST00000492339 ENST00000457529 ENST00000446600(uc003ufl.1) ENST00000413936(uc003ufj.4 uc003ufk.4)
    ENST00000423646 ENST00000438930 ENST00000430490 ENST00000442516 ENST00000429179
    ENST00000435861 ENST00000472426 ENST00000446820 ENST00000467729 ENST00000435251

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DTX2 (see all 19):
    hsa-miR-137 hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidDTX2 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX2
    Sirion Biotech Customized lentivirus for stable overexpression of DTX2 
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    Additional mRNA sequence: 

    AB040961.1 AK023924.1 AK026252.1 AK293226.1 AY225124.1 AY225125.1 BC008856.2 BC013192.1 
    BC018555.1 BC026059.2 BC064535.1 BC093079.1 DQ010329.1 DQ082728.1 DQ082730.1 

    24 DOTS entries:

    DT.100682666  DT.92469716  DT.95192094  DT.95214454  DT.114138  DT.100810678  DT.40239991  DT.100810690 
    DT.100720557  DT.121099383  DT.121099330  DT.121099351  DT.121099373  DT.100810682  DT.100810684  DT.101987018 
    DT.121099342  DT.102834853  DT.121124795  DT.40224247  DT.91713744  DT.91880229  DT.95078662  DT.97860962 

    24/195 AceView cDNA sequences (see all 195):

    CB993822 BI334999 CB991425 CB992094 BU689947 AY225124 AI001005 BM982854 
    AL555691 BU145636 BQ102509 BQ086180 BU542343 AW274887 BI333802 BM837596 
    AY225125 BU616049 BM665144 BM974787 AL561485 BI769881 AI921688 CB989696 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DTX2 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a ·
    SP1:                                                                                                                                                        -   
    SP2:                                -                 -     -     -     -     -     -     -                                                                     
    SP3:                                -                 -     -     -     -                 -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                        -   

    ExUns: 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:        -                                 


    ECgene alternative splicing isoforms for DTX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DTX2 expression in normal human tissues (normalized intensities)      DTX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DTX2 Expression
    About this image


    DTX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Secondary Oocyte Antral Follicle
             oocyte   
     
     Testis (Reproductive System)
             sperm   
     
     Adipose (Muscoskeletal System)
             epididymal fat pads   
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Eye (Sensory Organs)
             retinal progenitor cell e16.5   

    See DTX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DTX2

    SOURCE GeneReport for Unigene cluster: Hs.187058
        SABiosciences Expression via Pathway-Focused PCR Arrays including DTX2: 
              Ubiquitin Ligases in human mouse rat
              Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DTX2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtx21 , 5 deltex 2 homolog (Drosophila)1, 5 84.41(n)1
    85.44(a)1
      5 (75.64 cM)5
    741981  NM_001256096.11  NP_001243025.11 
     1359948005 
    chicken
    (Gallus gallus)
    Aves DTX21 deltex homolog 2 (Drosophila) 66.98(n)
    64.74(a)
      417515  XM_415763.3  XP_415763.3 
    lizard
    (Anolis carolinensis)
    Reptilia DTX26
    deltex homolog 2 (Drosophila)
    57(a)
    1 ↔ 1
    GL343889.1(38092-55820)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC537372 similar to deltex homolog 2 (Drosophila) 72.65(n)    BC047978.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1948001 zgc:194800 61.7(n)
    59.66(a)
      568626  NM_001127307.1  NP_001120779.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dx6
    deltex
    22(a)
    1 → many
    X(6428043-6432615)


    ENSEMBL Gene Tree for DTX2 (if available)
    TreeFam Gene Tree for DTX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DTX2 gene
    DTX12  DTX42  DTX3L2  DTX32  
    3 SIMAP similar genes for DTX2 using alignment to 16 protein entries:     DTX2_HUMAN (see all proteins):
    DTX1    DTX4    DTX3

    DTX2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DTX2
    PGOHUM00000250953


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/480 SNPs in DTX2 are shown (see all 480)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0169204
    ----see VAR_0169202 A T mis40--------
    VAR_0169214
    ----see VAR_0169212 G E mis40--------
    rs3721639381,2
    C--76089091(+) CCCCAC/TCTCCT 3 -- us2k10--------
    rs1999236541,2
    C--76089465(+) TCTTTA/CTTTTC 3 -- us2k10--------
    rs284377961,2
    C--76089647(+) ACACCC/TAGTTA 3 -- us2k1 tfbs30--------
    rs132369171,2
    C--76089671(+) ttattT/Attttt 3 -- us2k12Minor allele frequency- A:0.25NA 4
    rs624756251,2
    C--76089963(+) CCCGGA/CCTCCA 3 -- us2k10--------
    rs2021091591,2
    C--76090551(+) GAGAGA/TAAAAA 3 -- us2k10--------
    rs1472995551,2
    C--76092361(+) CATGGC/GCGACA 3 -- int10--------
    rs1420372911,2
    C--76092407(+) AAACT-/AAAAAAAC 3 -- int10--------

    HapMap Linkage Disequilibrium report for DTX2 (76090972 - 76135312 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/37 variations for DTX2 (see all 37):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv120n16CNV Deletion17901297
    esv2734687CNV Deletion23290073
    dgv1218e199CNV Deletion23128226
    dgv21n31CNV Duplication19718026
    esv2422494CNV Duplication17116639
    nsv471446CNV Duplication19718026
    nsv509211CNV Insertion20534489
    dgv121n16CNV Insertion17901297
    dgv233e55CNV Loss17911159
    dgv235e55CNV Loss17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613141    OMIM disorders: --

    2 diseases for DTX2:    About MalaCards
    pthirus pubis infestation    


    DTX2 for disorders           About GeneDecksing


    Export disorders for DTX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DTX2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with DTX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PubMed id 12670957)1, 2, 9 Takeyama K.... Shipp M.A. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. (PubMed id 11564735)1, 2 Yamamoto N....Nakafuku M. (2001)
    6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    7. cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. (PubMed id 17286044)1, 9 Yi Z....Wu Z. (2006)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113878 HGNC: 15973 AceView: DTX2 Ensembl:ENSG00000091073 euGenes: HUgn113878
    ECgene: DTX2 Kegg: 113878 H-InvDB: DTX2

    (According to HUGE)
    About This Section
    HUGE: KIAA1528

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DTX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DTX2 gene:
    Search GeneIP for patents involving DTX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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