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Aliases for DTX2 Gene

Aliases for DTX2 Gene

  • Deltex 2, E3 Ubiquitin Ligase 2 3
  • Protein Deltex-2 3 4
  • KIAA1528 4 6
  • Deltex2 3 4
  • RNF58 3 4
  • HDTX2 3 4
  • Probable E3 Ubiquitin-Protein Ligase DTX2 3
  • Deltex (Drosophila) Homolog 2 2
  • Deltex Homolog 2 (Drosophila) 2
  • Zinc Ion Binding Protein 3
  • Ring Finger Protein 58 3
  • RING Finger Protein 58 4
  • Deltex Homolog 2 3
  • EC 6.3.2.- 4

External Ids for DTX2 Gene

Previous GeneCards Identifiers for DTX2 Gene

  • GC07P074626
  • GC07P075689
  • GC07P075703
  • GC07P075735
  • GC07P075928
  • GC07P076090
  • GC07P071168

Summaries for DTX2 Gene

Entrez Gene Summary for DTX2 Gene

  • DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

GeneCards Summary for DTX2 Gene

DTX2 (Deltex 2, E3 Ubiquitin Ligase) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ligase activity. An important paralog of this gene is DTX4.

UniProtKB/Swiss-Prot for DTX2 Gene

  • Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity

Gene Wiki entry for DTX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX2 Gene

Genomics for DTX2 Gene

Regulatory Elements for DTX2 Gene

Genomic Location for DTX2 Gene

Start:
76,461,655 bp from pter
End:
76,505,995 bp from pter
Size:
44,341 bases
Orientation:
Plus strand

Genomic View for DTX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX2 Gene

Proteins for DTX2 Gene

  • Protein details for DTX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UW9-DTX2_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase DTX2
    Protein Accession:
    Q86UW9
    Secondary Accessions:
    • Q6XM87
    • Q6XM88
    • Q96H69
    • Q9H890
    • Q9P200

    Protein attributes for DTX2 Gene

    Size:
    622 amino acids
    Molecular mass:
    67246 Da
    Quaternary structure:
    • Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 (By similarity).
    SequenceCaution:
    • Sequence=BAA96052.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DTX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX2 Gene

Proteomics data for DTX2 Gene at MOPED

Post-translational modifications for DTX2 Gene

  • Ubiquitination at Lys249 and Lys553
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DTX2 (DTX2)

No data available for DME Specific Peptides for DTX2 Gene

Domains for DTX2 Gene

Gene Families for DTX2 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for DTX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UW9

UniProtKB/Swiss-Prot:

DTX2_HUMAN :
  • Q86UW9
Domain:
  • The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • Contains 2 WWE domains.
Family:
  • Belongs to the Deltex family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with DTX2: view

Function for DTX2 Gene

Molecular function for DTX2 Gene

UniProtKB/Swiss-Prot Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity

Enzyme Numbers (IUBMB) for DTX2 Gene

Gene Ontology (GO) - Molecular Function for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with DTX2: view
genes like me logo Genes that share phenotypes with DTX2: view

Animal Models for DTX2 Gene

MGI Knock Outs for DTX2:

miRNA for DTX2 Gene

miRTarBase miRNAs that target DTX2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DTX2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for DTX2 Gene

Localization for DTX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX2 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTX2 Gene COMPARTMENTS Subcellular localization image for DTX2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with DTX2: view

Pathways for DTX2 Gene

genes like me logo Genes that share pathways with DTX2: view

Pathways by source for DTX2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q86UW9-DTX2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DTX2: view

Transcripts for DTX2 Gene

Unigene Clusters for DTX2 Gene

Deltex homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DTX2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a ·
SP1: -
SP2: - - - - - - - -
SP3: - - - - - -
SP4:
SP5: -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: - - - -
SP12: - - - - - - - - -
SP13: - -
SP14:
SP15: - - - - - -
SP16: - - - - - - -
SP17:

ExUns: 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -

Relevant External Links for DTX2 Gene

GeneLoc Exon Structure for
DTX2
ECgene alternative splicing isoforms for
DTX2

Expression for DTX2 Gene

mRNA expression in normal human tissues for DTX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DTX2 Gene

This gene is overexpressed in Esophagus - Mucosa (4.7) and Whole Blood (4.3).

Protein differential expression in normal tissues for DTX2 Gene

This gene is overexpressed in Cervix (64.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DTX2 Gene

SOURCE GeneReport for Unigene cluster for DTX2 Gene Hs.187058

genes like me logo Genes that share expressions with DTX2: view

Expression partners for DTX2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DTX2 Gene

Orthologs for DTX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DTX2 35
  • 87.65 (n)
  • 90.91 (a)
DTX2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DTX2 35
  • 88.3 (n)
  • 91.75 (a)
DTX2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtx2 35
  • 83.76 (n)
  • 84.63 (a)
Dtx2 16
Dtx2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DTX2 35
  • 98.87 (n)
  • 98.55 (a)
DTX2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtx2 35
  • 83.87 (n)
  • 84.79 (a)
oppossum
(Monodelphis domestica)
Mammalia DTX2 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTX2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTX2 35
  • 66.98 (n)
  • 64.74 (a)
DTX2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTX2 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtx2 35
  • 60.09 (n)
  • 58.26 (a)
Str.4864 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53737 35
zebrafish
(Danio rerio)
Actinopterygii dtx2 35
  • 65.83 (n)
  • 64.22 (a)
dtx2 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dx 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7641 36
  • 30 (a)
OneToMany
Species with no ortholog for DTX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX2 Gene

ENSEMBL:
Gene Tree for DTX2 (if available)
TreeFam:
Gene Tree for DTX2 (if available)

Paralogs for DTX2 Gene

Paralogs for DTX2 Gene

Pseudogenes.org Pseudogenes for DTX2 Gene

genes like me logo Genes that share paralogs with DTX2: view

Variants for DTX2 Gene

Sequence variations from dbSNP and Humsavar for DTX2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7398 -- 76,505,817(+) GCTTA(A/G)GATGC utr-variant-3-prime
rs723378 -- 76,486,163(+) ATCTA(C/T)GCGCT intron-variant
rs723380 -- 76,486,232(+) TCTGA(C/T)GGATG intron-variant
rs887044 -- 76,479,395(-) AGCAT(C/T)GCTAA intron-variant, upstream-variant-2KB
rs917425 -- 76,500,368(+) GAAGG(C/G)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTX2 Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
dgv2104e1 CNV Complex 17122850
esv2422494 CNV Duplication 17116639
nsv428174 CNV Gain 18775914
dgv232e55 CNV Gain 17911159
dgv2106e1 CNV Complex 17122850
dgv233e55 CNV Loss 17911159
nsv7403 OTHER Inversion 18451855
dgv2107e1 CNV Complex 17122850
dgv234e55 CNV Gain 17911159
dgv235e55 CNV Loss 17911159
nsv517634 CNV Gain+Loss 19592680
esv23516 CNV Gain 19812545
esv33074 CNV Gain 17666407
dgv21n31 CNV Duplication 19718026
dgv7327n71 CNV Gain 21882294
dgv1218e199 CNV Deletion 23128226
nsv888391 CNV Loss 21882294
esv2734687 CNV Deletion 23290073
nsv471446 CNV Duplication 19718026
nsv482106 CNV Gain 20164927
nsv888395 CNV Loss 21882294
dgv7328n71 CNV Gain 21882294
dgv121n16 CNV Insertion 17901297
nsv8159 CNV Loss 18304495
nsv888401 CNV Gain+Loss 21882294
nsv888408 CNV Gain+Loss 21882294
nsv888410 CNV Gain 21882294
nsv888415 CNV Gain 21882294
nsv509211 CNV Insertion 20534489
nsv510964 CNV Complex 20534489
dgv7329n71 CNV Gain 21882294
dgv7330n71 CNV Gain 21882294
dgv7331n71 CNV Loss 21882294
nsv5797 CNV Loss 18451855

Relevant External Links for DTX2 Gene

HapMap Linkage Disequilibrium report
DTX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX2 Gene

Disorders for DTX2 Gene

No disorders were found for DTX2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DTX2 Gene

Publications for DTX2 Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K. … Shipp M.A. (J. Biol. Chem. 2003) 2 3 4 23
  2. cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. (PMID: 17286044) Yi Z. … Wu Z. (DNA Seq. 2006) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. (PMID: 11564735) Yamamoto N. … Nakafuku M. (J. Biol. Chem. 2001) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for DTX2 Gene

Sources for DTX2 Gene

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