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Aliases for DTX2 Gene

Aliases for DTX2 Gene

  • Deltex E3 Ubiquitin Ligase 2 2 3 5
  • RING-Type E3 Ubiquitin Transferase DTX2 3 4
  • Deltex 2, E3 Ubiquitin Ligase 2 3
  • Protein Deltex-2 3 4
  • Deltex2 3 4
  • RNF58 3 4
  • HDTX2 3 4
  • Probable E3 Ubiquitin-Protein Ligase DTX2 3
  • Deltex (Drosophila) Homolog 2 2
  • Deltex Homolog 2 (Drosophila) 2
  • Zinc Ion Binding Protein 3
  • Ring Finger Protein 58 3
  • RING Finger Protein 58 4
  • Deltex Homolog 2 3
  • EC 2.3.2.27 4
  • KIAA1528 4

External Ids for DTX2 Gene

Previous GeneCards Identifiers for DTX2 Gene

  • GC07P074626
  • GC07P075689
  • GC07P075703
  • GC07P075735
  • GC07P075928
  • GC07P076090
  • GC07P071168

Summaries for DTX2 Gene

Entrez Gene Summary for DTX2 Gene

  • DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

GeneCards Summary for DTX2 Gene

DTX2 (Deltex E3 Ubiquitin Ligase 2) is a Protein Coding gene. Among its related pathways are Signaling by NOTCH1 and Notch signaling pathway (KEGG). GO annotations related to this gene include ligase activity. An important paralog of this gene is DTX1.

UniProtKB/Swiss-Prot for DTX2 Gene

  • Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Gene Wiki entry for DTX2 Gene

Additional gene information for DTX2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX2 Gene

Genomics for DTX2 Gene

Regulatory Elements for DTX2 Gene

Enhancers for DTX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H076290 2 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -167.1 -167101 8 HNRNPUL1 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF548 STAG3L1 PMS2P3 FAM185BP POMZP3 DTX2P1 SRRM3 PMS2P9 DTX2 SPDYE18 ENSG00000250778
GH07H075637 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -822.3 -822277 3 ATF1 ARNT ZNF133 SIN3A GLI4 ZNF2 ZBTB7B ETS1 ZNF766 GLIS2 SPDYE5 HIP1 STAG3L1 PMS2P3 NSUN5P1 GTF2IRD2B GTF2IRD2 LOC101926943 TRIM73 DTX2
GH07H076301 1.6 Ensembl ENCODE dbSUPER 10.7 -154.9 -154906 10 HDGF FOXA2 PKNOX1 ARID4B SIN3A FEZF1 ZBTB7B YY1 SLC30A9 ZNF143 STAG3L1 PMS2P3 POMZP3 SPDYE5 SPDYE18 PMS2P9 DTX2P1 SPDYE17 NSUN5P1 SRRM3
GH07H075989 1.6 Ensembl ENCODE dbSUPER 10.2 -471.4 -471376 2 HNRNPUL1 PKNOX1 ATF1 ARNT SIN3A TCF12 ZNF766 GLIS2 CBX5 GATA2 STYXL1 STAG3L1 DTX2P1 PMS2P3 DTX2 GTF2IRD2B POMZP3 TMEM120A SNORA14A GC07P075946
GH07H076356 1.4 ENCODE dbSUPER 10.7 -103.0 -103044 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 PMS2P3 POMZP3 STAG3L1 SPDYE18 PMS2P9 DTX2P1 FAM185BP LOC100133091 NSUN5P1 SPDYE5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DTX2 on UCSC Golden Path with GeneCards custom track

Promoters for DTX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000213931 445 1401

Genomic Location for DTX2 Gene

Chromosome:
7
Start:
76,461,655 bp from pter
End:
76,505,998 bp from pter
Size:
44,344 bases
Orientation:
Plus strand

Genomic View for DTX2 Gene

Genes around DTX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX2 Gene

Proteins for DTX2 Gene

  • Protein details for DTX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UW9-DTX2_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase DTX2
    Protein Accession:
    Q86UW9
    Secondary Accessions:
    • Q4ZH49
    • Q6XM87
    • Q6XM88
    • Q96H69
    • Q9H890
    • Q9P200

    Protein attributes for DTX2 Gene

    Size:
    622 amino acids
    Molecular mass:
    67246 Da
    Quaternary structure:
    • Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1.
    SequenceCaution:
    • Sequence=BAA96052.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DTX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX2 Gene

Post-translational modifications for DTX2 Gene

  • Ubiquitination at isoforms=2249 and posLast=553553
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DTX2 Gene

Domains & Families for DTX2 Gene

Gene Families for DTX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DTX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UW9

UniProtKB/Swiss-Prot:

DTX2_HUMAN :
  • The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • Belongs to the Deltex family.
Domain:
  • The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Family:
  • Belongs to the Deltex family.
genes like me logo Genes that share domains with DTX2: view

Function for DTX2 Gene

Molecular function for DTX2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Enzyme Numbers (IUBMB) for DTX2 Gene

Phenotypes From GWAS Catalog for DTX2 Gene

Gene Ontology (GO) - Molecular Function for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DTX2: view
genes like me logo Genes that share phenotypes with DTX2: view

Animal Models for DTX2 Gene

MGI Knock Outs for DTX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DTX2 Gene

Localization for DTX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX2 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000269 PubMed:11564735}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTX2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with DTX2: view

Pathways & Interactions for DTX2 Gene

genes like me logo Genes that share pathways with DTX2: view

Pathways by source for DTX2 Gene

1 GeneTex pathway for DTX2 Gene
1 Cell Signaling Technology pathway for DTX2 Gene
1 BioSystems pathway for DTX2 Gene

UniProtKB/Swiss-Prot Q86UW9-DTX2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DTX2: view

No data available for SIGNOR curated interactions for DTX2 Gene

Drugs & Compounds for DTX2 Gene

No Compound Related Data Available

Transcripts for DTX2 Gene

Unigene Clusters for DTX2 Gene

Deltex homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a ·
SP1: -
SP2: - - - - - - - -
SP3: - - - - - -
SP4:
SP5: -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: - - - -
SP12: - - - - - - - - -
SP13: - -
SP14:
SP15: - - - - - -
SP16: - - - - - - -
SP17:

ExUns: 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -

Relevant External Links for DTX2 Gene

GeneLoc Exon Structure for
DTX2
ECgene alternative splicing isoforms for
DTX2

Expression for DTX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DTX2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.7) and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for DTX2 Gene

This gene is overexpressed in Cervix (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DTX2 Gene



Protein tissue co-expression partners for DTX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DTX2 Gene:

DTX2

SOURCE GeneReport for Unigene cluster for DTX2 Gene:

Hs.187058

Evidence on tissue expression from TISSUES for DTX2 Gene

  • Nervous system(4.5)
  • Muscle(4.1)
  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with DTX2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTX2 Gene

Orthologs for DTX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTX2 33 34
  • 98.87 (n)
dog
(Canis familiaris)
Mammalia DTX2 33 34
  • 88.3 (n)
cow
(Bos Taurus)
Mammalia DTX2 33 34
  • 87.65 (n)
rat
(Rattus norvegicus)
Mammalia Dtx2 33
  • 83.87 (n)
mouse
(Mus musculus)
Mammalia Dtx2 33 16 34
  • 83.76 (n)
oppossum
(Monodelphis domestica)
Mammalia DTX2 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTX2 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTX2 33 34
  • 66.98 (n)
lizard
(Anolis carolinensis)
Reptilia DTX2 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtx2 33
  • 60.09 (n)
Str.4864 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53737 33
zebrafish
(Danio rerio)
Actinopterygii dtx2 33 34
  • 65.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta dx 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7641 34
  • 30 (a)
OneToMany
Species where no ortholog for DTX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX2 Gene

ENSEMBL:
Gene Tree for DTX2 (if available)
TreeFam:
Gene Tree for DTX2 (if available)

Paralogs for DTX2 Gene

Paralogs for DTX2 Gene

Pseudogenes.org Pseudogenes for DTX2 Gene

genes like me logo Genes that share paralogs with DTX2: view

Variants for DTX2 Gene

Sequence variations from dbSNP and Humsavar for DTX2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000130029 -- 76,483,793(+) TGACA(C/T)CTTTA intron-variant
rs1000325454 -- 76,465,079(+) ACTTA(C/G)AGGTG intron-variant
rs1000603294 -- 76,483,583(+) TGTCA(C/G)CGCGG intron-variant
rs1000930599 -- 76,469,032(+) AGTGC(G/T)GGGAT intron-variant
rs1000978791 -- 76,479,403(+) GCTTC(A/C)GGGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DTX2 Gene

Variant ID Type Subtype PubMed ID
dgv11464n54 CNV gain 21841781
dgv11465n54 CNV loss 21841781
dgv11466n54 CNV loss 21841781
dgv120n16 CNV deletion 17901297
dgv1218e199 CNV deletion 23128226
dgv121n16 CNV insertion 17901297
dgv21n31 CNV gain 19718026
dgv232e55 CNV gain 17911159
dgv233e55 CNV loss 17911159
dgv234e55 CNV gain 17911159
dgv235e55 CNV loss 17911159
dgv6470n100 CNV loss 25217958
dgv6471n100 CNV gain 25217958
dgv6472n100 CNV loss 25217958
dgv6473n100 CNV gain 25217958
dgv6474n100 CNV loss 25217958
dgv6475n100 CNV gain 25217958
dgv6476n100 CNV gain 25217958
dgv6477n100 CNV loss 25217958
esv23516 CNV gain 19812545
esv2422494 CNV duplication 17116639
esv2734687 CNV deletion 23290073
esv2761124 CNV gain 21179565
esv2764008 CNV gain+loss 21179565
esv33074 CNV gain 17666407
esv3613764 CNV loss 21293372
esv3613765 CNV gain 21293372
esv3613766 CNV loss 21293372
esv3891147 CNV gain+loss 25118596
nsv1034692 CNV gain+loss 25217958
nsv1074521 CNV deletion 25765185
nsv1144183 CNV deletion 24896259
nsv1145148 CNV deletion 24896259
nsv428174 CNV gain 18775914
nsv471446 CNV gain 19718026
nsv482106 CNV gain 20164927
nsv509211 CNV insertion 20534489
nsv510964 OTHER complex 20534489
nsv517634 CNV gain+loss 19592680
nsv528969 CNV gain 19592680
nsv5797 CNV deletion 18451855
nsv607585 CNV gain 21841781
nsv607593 CNV gain 21841781
nsv7403 OTHER inversion 18451855
nsv8159 CNV loss 18304495
nsv951360 CNV deletion 24416366
nsv970893 CNV duplication 23825009
nsv970894 CNV duplication 23825009
nsv981537 CNV duplication 23825009

Variation tolerance for DTX2 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX2 Gene

Disorders for DTX2 Gene

Relevant External Links for DTX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTX2

No disorders were found for DTX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTX2 Gene

Publications for DTX2 Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K … Shipp MA (The Journal of biological chemistry 2003) 2 3 4 22 60
  2. cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. (PMID: 17286044) Yi Z … Wu Z (DNA sequence : the journal of DNA sequencing and mapping 2006) 3 22 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60

Products for DTX2 Gene

Sources for DTX2 Gene

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