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Aliases for DTX2 Gene

Aliases for DTX2 Gene

  • Deltex E3 Ubiquitin Ligase 2 2 3 5
  • Deltex 2, E3 Ubiquitin Ligase 2 3
  • Protein Deltex-2 3 4
  • Deltex2 3 4
  • RNF58 3 4
  • HDTX2 3 4
  • Probable E3 Ubiquitin-Protein Ligase DTX2 3
  • Deltex (Drosophila) Homolog 2 2
  • Deltex Homolog 2 (Drosophila) 2
  • Zinc Ion Binding Protein 3
  • Ring Finger Protein 58 3
  • RING Finger Protein 58 4
  • Deltex Homolog 2 3
  • EC 6.3.2.- 4
  • KIAA1528 4

External Ids for DTX2 Gene

Previous GeneCards Identifiers for DTX2 Gene

  • GC07P074626
  • GC07P075689
  • GC07P075703
  • GC07P075735
  • GC07P075928
  • GC07P076090
  • GC07P071168

Summaries for DTX2 Gene

Entrez Gene Summary for DTX2 Gene

  • DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

GeneCards Summary for DTX2 Gene

DTX2 (Deltex E3 Ubiquitin Ligase 2) is a Protein Coding gene. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Notch signaling pathway (KEGG). GO annotations related to this gene include ligase activity. An important paralog of this gene is DTX4.

UniProtKB/Swiss-Prot for DTX2 Gene

  • Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Gene Wiki entry for DTX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX2 Gene

Genomics for DTX2 Gene

Regulatory Elements for DTX2 Gene

Enhancers for DTX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F077326 1 Ensembl ENCODE 5.5 +866.1 866051 3.4 JUN MAX CEBPG BMI1 EED FOS NFE2L2 MTA2 HLF BHLHE40 GSAP FGL2 PTPN12 DTX2 PIR39731 LOC102723791
GH07F077288 0.7 Ensembl 5.1 +827.2 827246 1.0 ZMYM3 GSAP ENSG00000250990 CCDC146 FGL2 PTPN12 DTX2 LOC102723791 PIR39731
GH07F077278 0.7 FANTOM5 4.9 +816.7 816725 0.2 DTX2 LOC102723791 PIR56172
GH07F077306 0.5 Ensembl 4.9 +845.0 845046 0.6 ZNF316 MAFG NFE2 FOS EMSY FGL2 PTPN12 DTX2 LOC102723791 PIR39731
GH07F077329 0.5 Ensembl ENCODE 4.8 +869.3 869346 2.8 HDGF TBL1XR1 SIN3A ARID4B BMI1 RAD21 EGR1 ZNF143 ETV6 CREM GSAP PTPN12 DTX2 PMS2P9 PIR39731 LOC102723791
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DTX2 on UCSC Golden Path with GeneCards custom track

Promoters for DTX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001893153 445 1801 JUNB

Genomic Location for DTX2 Gene

Chromosome:
7
Start:
76,461,655 bp from pter
End:
76,505,998 bp from pter
Size:
44,344 bases
Orientation:
Plus strand

Genomic View for DTX2 Gene

Genes around DTX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX2 Gene

Proteins for DTX2 Gene

  • Protein details for DTX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UW9-DTX2_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase DTX2
    Protein Accession:
    Q86UW9
    Secondary Accessions:
    • Q6XM87
    • Q6XM88
    • Q96H69
    • Q9H890
    • Q9P200

    Protein attributes for DTX2 Gene

    Size:
    622 amino acids
    Molecular mass:
    67246 Da
    Quaternary structure:
    • Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 (By similarity).
    SequenceCaution:
    • Sequence=BAA96052.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DTX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX2 Gene

Post-translational modifications for DTX2 Gene

  • Ubiquitination at Lys 249 and Lys 553
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DTX2 Gene

Domains & Families for DTX2 Gene

Gene Families for DTX2 Gene

Protein Domains for DTX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UW9

UniProtKB/Swiss-Prot:

DTX2_HUMAN :
  • The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • Belongs to the Deltex family.
  • Contains 1 RING-type zinc finger.
Domain:
  • The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • Contains 2 WWE domains.
Family:
  • Belongs to the Deltex family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with DTX2: view

Function for DTX2 Gene

Molecular function for DTX2 Gene

UniProtKB/Swiss-Prot Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Enzyme Numbers (IUBMB) for DTX2 Gene

Gene Ontology (GO) - Molecular Function for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DTX2: view
genes like me logo Genes that share phenotypes with DTX2: view

Animal Models for DTX2 Gene

MGI Knock Outs for DTX2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DTX2 Gene

Localization for DTX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX2 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTX2 Gene COMPARTMENTS Subcellular localization image for DTX2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with DTX2: view

Pathways & Interactions for DTX2 Gene

genes like me logo Genes that share pathways with DTX2: view

Pathways by source for DTX2 Gene

1 GeneTex pathway for DTX2 Gene
1 Cell Signaling Technology pathway for DTX2 Gene
1 BioSystems pathway for DTX2 Gene

UniProtKB/Swiss-Prot Q86UW9-DTX2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0016567 protein ubiquitination IEA --
GO:0030212 hyaluronan metabolic process IEA --
genes like me logo Genes that share ontologies with DTX2: view

No data available for SIGNOR curated interactions for DTX2 Gene

Transcripts for DTX2 Gene

Unigene Clusters for DTX2 Gene

Deltex homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a ·
SP1: -
SP2: - - - - - - - -
SP3: - - - - - -
SP4:
SP5: -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: - - - -
SP12: - - - - - - - - -
SP13: - -
SP14:
SP15: - - - - - -
SP16: - - - - - - -
SP17:

ExUns: 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -

Relevant External Links for DTX2 Gene

GeneLoc Exon Structure for
DTX2
ECgene alternative splicing isoforms for
DTX2

Expression for DTX2 Gene

mRNA expression in normal human tissues for DTX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DTX2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.7) and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for DTX2 Gene

This gene is overexpressed in Cervix (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DTX2 Gene



Protein tissue co-expression partners for DTX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DTX2 Gene:

DTX2

SOURCE GeneReport for Unigene cluster for DTX2 Gene:

Hs.187058
genes like me logo Genes that share expression patterns with DTX2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DTX2 Gene

Orthologs for DTX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTX2 34 35
  • 98.87 (n)
dog
(Canis familiaris)
Mammalia DTX2 34 35
  • 88.3 (n)
cow
(Bos Taurus)
Mammalia DTX2 34 35
  • 87.65 (n)
rat
(Rattus norvegicus)
Mammalia Dtx2 34
  • 83.87 (n)
mouse
(Mus musculus)
Mammalia Dtx2 34 16 35
  • 83.76 (n)
oppossum
(Monodelphis domestica)
Mammalia DTX2 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTX2 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTX2 34 35
  • 66.98 (n)
lizard
(Anolis carolinensis)
Reptilia DTX2 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtx2 34
  • 60.09 (n)
Str.4864 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53737 34
zebrafish
(Danio rerio)
Actinopterygii dtx2 34 35
  • 65.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta dx 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7641 35
  • 30 (a)
OneToMany
Species where no ortholog for DTX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX2 Gene

ENSEMBL:
Gene Tree for DTX2 (if available)
TreeFam:
Gene Tree for DTX2 (if available)

Paralogs for DTX2 Gene

Paralogs for DTX2 Gene

Pseudogenes.org Pseudogenes for DTX2 Gene

genes like me logo Genes that share paralogs with DTX2: view

Variants for DTX2 Gene

Sequence variations from dbSNP and Humsavar for DTX2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1010933 -- 76,505,502(+) CGCAA(C/T)ATTAC reference, synonymous-codon
rs10247123 -- 76,483,163(+) CAACG(A/G)CCGCT intron-variant
rs10257113 -- 76,502,756(+) CGCCT(A/C)CCCCT intron-variant
rs1051646 -- 76,505,906(+) GAGTA(A/G)AGACT utr-variant-3-prime
rs1055094 -- 76,474,928(-) TCGCC(A/G)CAAAT intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DTX2 Gene

Variant ID Type Subtype PubMed ID
dgv11464n54 CNV gain 21841781
dgv11465n54 CNV loss 21841781
dgv11466n54 CNV loss 21841781
dgv120n16 CNV deletion 17901297
dgv1218e199 CNV deletion 23128226
dgv121n16 CNV insertion 17901297
dgv21n31 CNV gain 19718026
dgv232e55 CNV gain 17911159
dgv233e55 CNV loss 17911159
dgv234e55 CNV gain 17911159
dgv235e55 CNV loss 17911159
dgv6470n100 CNV loss 25217958
dgv6471n100 CNV gain 25217958
dgv6472n100 CNV loss 25217958
dgv6473n100 CNV gain 25217958
dgv6474n100 CNV loss 25217958
dgv6475n100 CNV gain 25217958
dgv6476n100 CNV gain 25217958
dgv6477n100 CNV loss 25217958
esv23516 CNV gain 19812545
esv2422494 CNV duplication 17116639
esv2734687 CNV deletion 23290073
esv2761124 CNV gain 21179565
esv2764008 CNV gain+loss 21179565
esv33074 CNV gain 17666407
esv3613764 CNV loss 21293372
esv3613765 CNV gain 21293372
esv3613766 CNV loss 21293372
esv3891147 CNV gain+loss 25118596
nsv1034692 CNV gain+loss 25217958
nsv1074521 CNV deletion 25765185
nsv1144183 CNV deletion 24896259
nsv1145148 CNV deletion 24896259
nsv428174 CNV gain 18775914
nsv471446 CNV gain 19718026
nsv482106 CNV gain 20164927
nsv509211 CNV insertion 20534489
nsv510964 OTHER complex 20534489
nsv517634 CNV gain+loss 19592680
nsv528969 CNV gain 19592680
nsv5797 CNV deletion 18451855
nsv607585 CNV gain 21841781
nsv607593 CNV gain 21841781
nsv7403 OTHER inversion 18451855
nsv8159 CNV loss 18304495
nsv951360 CNV deletion 24416366
nsv970893 CNV duplication 23825009
nsv970894 CNV duplication 23825009
nsv981537 CNV duplication 23825009

Variation tolerance for DTX2 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX2 Gene

Disorders for DTX2 Gene

Relevant External Links for DTX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTX2

No disorders were found for DTX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTX2 Gene

Publications for DTX2 Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K. … Shipp M.A. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. (PMID: 17286044) Yi Z. … Wu Z. (DNA Seq. 2006) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for DTX2 Gene

Sources for DTX2 Gene

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