Aliases for DTX2 Gene
External Ids for DTX2 Gene
Previous GeneCards Identifiers for DTX2 Gene
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
GeneCards Summary for DTX2 Gene
DTX2 (Deltex 2, E3 Ubiquitin Ligase) is a Protein Coding gene. Diseases associated with DTX2 include Parasitic Ectoparasitic Infectious Disease. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Wnt / Hedgehog / Notch. GO annotations related to this gene include ligase activity. An important paralog of this gene is DTX3.
UniProtKB/Swiss-Prot for DTX2 Gene
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.