Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DTX1 Gene

protein-coding   GIFtS: 59
GCID: GC12P113495

deltex homolog 1 (Drosophila)
 Explore 3 diseases affiliated with
DTX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DTX1    

Aliases
for DTX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Deltex Homolog 1 (Drosophila)1 2     Deltex13
HDx-11     E3 Ubiquitin-Protein Ligase DTX12
Protein Deltex-12 3     Deltex13
HDTX11     EC 6.3.2.-3

External Ids:    HGNC: 30601   Entrez Gene: 18402   Ensembl: ENSG000001351447   OMIM: 6025825   UniProtKB: Q86Y013   

Export aliases for DTX1 gene to outside databases

Previous GC identifers: GC12P112390 GC12P113014 GC12P113278 GC12P111907 GC12P111958 GC12P110508


Summaries
for DTX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DTX1:
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The
human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription
factor activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01
Function: Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of
MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator
of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of
cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator,
depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the
transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be
involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell
development, suggesting that it can antagonize NOTCH1

Gene Wiki entry for DTX1


Genomic Views
for DTX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DTX1 gene promoter:
         Max1   AhR   Sox5   p53   AML1a   RORalpha2   Arnt   Ik-2   Sox9   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DTX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DTX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24

DTX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTX1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113495:  view genomic region     (about GC identifiers)

Start:
 113,494,514 bp from pter      End:
 113,535,833 bp from pter
Size:
 41,320 bases      Orientation:
 plus strand

Proteins
for DTX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase DTX1  
Size: 620 amino acids; 67368 Da
Subunit: Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 via its
N-terminus region and EIF3F, the interaction is required for NOTCH1 deubiquitination. Interacts with EP300. Forms a
heterodimer with BBAP; the heterodimerization leading to an increase of in vitro ubiquitin ligase activity. Interacts
with ITCH
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially
nuclear
Secondary accessions: O60630 Q9BS04

Explore the universe of human proteins at neXtProt for DTX1: NX_Q86Y01

Post-translational modifications:

  • Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86Y01

    • DTX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004407.2  
    ENSEMBL proteins: 
     ENSP00000257600  
    Reactome Protein details: Q86Y01
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for DTX1 
    GenScript Custom Purified and Recombinant Proteins Services for DTX1
    Novus Biologicals DTX1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DTX1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS9590294
    GO:0005829cytosol TAS--


    DTX1 for ontologies           About GeneDecksing



    DTX1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DTX1
    OriGene Antibodies: DTX1
    OriGene Custom Antibody Services for DTX1 
    GenScript Custom Superior Antibodies Services for DTX1
    Novus Biologicals DTX1 Antibody
    Abcam antibodies for DTX1 
    Uscn Antibodies for DTX1
    ThermoFisher Antibody for DTX1

    Assay Products for DTX1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DTX1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DTX1

    Protein Domains /
    Families
    for DTX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DTX1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001841 Znf_RING
     IPR004170 WWE-dom
     IPR018123 WWE-dom_subgr
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q86Y01

    ProtoNet protein and cluster: Q86Y01

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01
    Domain: The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin
    ligases (By similarity)
    Similarity: Belongs to the Deltex family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 WWE domains


    Function
    for DTX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01
    Function: Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of
    MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator
    of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of
    cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator,
    depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the
    transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be
    involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell
    development, suggesting that it can antagonize NOTCH1
    Induction: Regulated by NOTCH2

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DTX1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DTX1
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate DTX1 (see all 32):
    hsa-miR-194* hsa-miR-219-1-3p hsa-miR-1321 hsa-miR-765 hsa-miR-128 hsa-miR-1276 hsa-miR-629* hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DTX1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DTX1 (see all 4)
    OriGene shRNA RFP: DTX1
    OriGene siRNA: DTX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTX1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DTX1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DTX1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DTX1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DTX1 (NM_004416)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DTX1
    Search LifeMap BioReagents cell lines for DTX1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS9590294
    GO:0005112Notch binding IDA11564735
    GO:0005515protein binding IPI7671825
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    DTX1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DTX1:
     Big cells 

    Animal Models:
         Mouse knock-outs for DTX1: Dtx1tm1Crey Dtx1tm1.2Mzl Dtx1tm1Mjb
         8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Dtx1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     normal  renal/urinary system  respiratory system 

    DTX1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DTX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		Signaling by NOTCH1 HD Domain Mutants in Cancer1.00
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		FBXW7 Mutants and NOTCH1 in Cancer1.00
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 in Cancer1.00
    		Signaling by NOTCH0.77
    2Cleavage of DNER:NOTCH1 complex releases NICD1
    		Cleavage of DNER:NOTCH1 complex releases NICD11.00
    		Activated NOTCH1 Transmits Signal to the Nucleus0.20
    		Cleavage of CNTN1:NOTCH1 complex releases NICD10.67
    		Signal Transduction0.20
    3Notch Signaling Pathway
    		Notch Signaling Pathway1.00
    		Delta-Notch Signaling Pathway0.27
    		Notch signaling pathway0.82
    4Disease
    		Disease1.00
    5Notch signaling pathway
    		Notch signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for DTX1 
        Notch Signaling Pathway
    Delta-Notch Signaling Pathway
    Notch signaling pathway
    Presenilin action in Notch and Wnt signaling

    5/16        Reactome Pathways for DTX1 (see all 16)
        Cleavage of CNTN1:NOTCH1 complex releases NICD1
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer
    Disease


    1         Kegg Pathway  (Kegg details for DTX1):
        Notch signaling pathway

    UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01
    Pathway: Protein modification; protein ubiquitination


    DTX1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DTX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for DTX1 (Q86Y012, 3 ENSP000002576004) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-3381104 MINT-3381037 I2D: score=2 STRING: ENSP00000363998
    UBCP0CG482, 3, ENSP000003448184MINT-3381152 MINT-3381175 I2D: score=1 STRING: ENSP00000344818
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent NAS11564735
    GO:0006366transcription from RNA polymerase II promoter TAS9590294
    GO:0007166cell surface receptor signaling pathway TAS9590294
    GO:0007219Notch signaling pathway TAS--
    GO:0008593regulation of Notch signaling pathway IGI11564735


    DTX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DTX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DTX1
    Search CenterWatch for drugs/clinical trials and news about DTX1 

    Transcripts
    for DTX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DTX1 gene: 
    NM_004416.2  

    Unigene Cluster for DTX1:

    Deltex homolog 1 (Drosophila)
    Hs.372152  [show with all ESTs]
    Unigene Representative Sequence: NM_004416
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548759 ENST00000257600(uc001tuk.1) ENST00000547974 ENST00000553140
    ENST00000547730

    miRNA
    Products:             		 OriGene 3'-UTR Clone: DTX1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DTX1
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate DTX1 (see all 32):
    hsa-miR-194* hsa-miR-219-1-3p hsa-miR-1321 hsa-miR-765 hsa-miR-128 hsa-miR-1276 hsa-miR-629* hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DTX1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DTX1 (see all 4)
    OriGene shRNA RFP: DTX1
    OriGene siRNA: DTX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTX1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DTX1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DTX1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DTX1 (NM_004416)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DTX1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DTX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTX1

    Additional cDNA sequence: 

    AF053700.1 BC005816.2 BC008321.1 BC048216.1 

    6 DOTS entries:

    DT.411502  DT.409220  DT.92420400  DT.40191795  DT.86855175  DT.92420401 

    24/87 AceView cDNA sequences (see all 87):

    AW408513 BQ061257 NM_004416 BC005816 CR620865 BU726168 BQ057477 AA810980 
    BX281251 AW408836 AW291600 AA721092 BM690009 BX349022 AF053700 BG546217 
    BE396937 BX350250 AI075286 BG757235 BC008321 AW408687 AW837772 BM685791 

    GeneLoc Exon Structure


    Expression
    for DTX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DTX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGTGGAAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DTX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyAfferent ArterioleJuxtaglomerular CellsKidney, Smooth Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See DTX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DTX1

    SOURCE GeneReport for Unigene cluster: Hs.372152

    UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01
    Tissue specificity: Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system,
    pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including DTX1: 
              Notch Signaling Targets in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DTX1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DTX1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTX1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTX1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX1

    Orthologs
    for DTX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DTX1 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dtx11 , 5 deltex 1 homolog (Drosophila)1, 5 88.66(n)1
    96.94(a)1    		   5 (60.64 cM)5
    143571  NM_008052.31  NP_032078.21 
     1206802025 
    chicken
    (Gallus gallus)    		 Aves DTX11 deltex homolog 1 (Drosophila) 80.8(n)
    84.49(a)    		   770657  XM_001233993.2  XP_001233994.2 
    lizard
    (Anolis carolinensis)    		 Reptilia DTX16
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343338.1(729791-748455)
    African clawed frog
    (Xenopus laevis)    		 Amphibia dtx2 hypothetical protein 74.7(n)    AJ431211.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01004876.16
    		 --
    		 76(a)
    		 1 ↔ 1
    		 Zv9_NA771(12736-43326)
    fruit fly
    (Drosophila melanogaster)    		 Insecta dx3 N receptor signaling pathway SH3-domain
    binding    		 42(a)     --


    ENSEMBL Gene Tree for DTX1 (if available)
    TreeFam Gene Tree for DTX1 (if available) 

    Paralogs
    for DTX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DTX1 gene
    DTX42  DTX3L2  DTX32  DTX22  
    2 SIMAP similar genes for DTX1 using alignment to 1 protein entry:     DTX1_HUMAN:
    DTX4    DTX2

    DTX1 for paralogs           About GeneDecksing



    Genomic Variants
    for DTX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/750 NCBI SNPs in DTX1 are shown (see all 750)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1177412381,2
    		F,--113493692(+) CCCCCC/GTCCCA 1 -- us2k11Minor allele frequency- G:0.07NA 120
    rs1924950941,2
    		--113493734(+) CTGGAA/GGACAG 1 -- us2k10--------
    rs1839278221,2
    		--113493846(+) CAGGTG/TGCTGT 1 -- us2k10--------
    rs73065761,2
    		C,F,--113493916(+) GTCCCC/TTNNNN 1 -- us2k1 tfbs3 trp38Minor allele frequency- T:0.07WA CSA NA EA 367
    rs1444601741,2
    		--113494010(+) TCAGAC/TCGGGG 1 -- us2k10--------
    rs734277181,2
    		C,--113494012(+) AGATCG/AGGGTT 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1859014691,2
    		--113494044(+) GCTTTC/TGTGAT 1 -- us2k10--------
    rs22547701,2
    		C,F,H,--113494323(-) GTCACC/GGGCTT 1 -- us2k117Minor allele frequency- G:0.19NS EA NA 2222
    rs1395474881,2
    		C,--113494610(+) GGAAA-/TTTC  
                GCTCG     		1 -- us2k10--------
    rs1898010141,2
    		--113494759(+) GAACGA/CGGGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DTX1 (113494514 - 113535833 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DTX1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DTX1
    DNA2.0 Custom Variant and Variant Library Synthesis for DTX1

    Disorders / Diseases
    for DTX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DTX1 for disorders           About GeneDecksing

    OMIM gene information: 602582    OMIM disorders: --

    3 diseases for DTX1:    About MalaCards
    noonan syndrome    osteosarcoma    neuronitis


    Export disorders for DTX1 gene to outside databases

    Publications
    for DTX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DTX1 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with DTX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human deltex is a conserved regulator of Notch signalling. (PubMed id 9590294)1, 2, 3 Matsuno K.... Artavanis-Tsakonas S. (1998)
    2. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. (PubMed id 11564735)1, 2, 9 Yamamoto N....Nakafuku M. (2001)
    3. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PubMed id 12670957)1, 2, 9 Takeyama K.... Shipp M.A. (2003)
    4. The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. (PubMed id 21124883)1, 2 Moretti J....Brou C. (2010)
    5. Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. (PubMed id 17028573)1, 2 Chastagner P....Brou C. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. (PubMed id 12753744)1, 2 Saito T.... Hirai H. (2003)
    8. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. (PubMed id 11869684)1, 2 Izon D.J.... Pear W.S. (2002)
    9. Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy. (PubMed id 19592273)1, 9 Hsiao H.W....Lai M.Z. (2009)
    10. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)

    External Searches for DTX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DTX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1840 HGNC: 3060 AceView: DTX1 Ensembl:ENSG00000135144 euGenes: HUgn1840
    ECgene: DTX1 Kegg: 1840 H-InvDB: DTX1

    Other Databases showing DTX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DTX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DTX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DTX1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DTX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DTX1 gene:
    Search GeneIP for patents involving DTX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DTX1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for DTX1 (DTX1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for DTX1   OriGene shRNA RFP for DTX1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DTX1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DTX1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for DTX1   OriGene 3'-UTR Clone for DTX1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DTX1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DTX1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DTX1   OriGene Custom Protein Services for DTX1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DTX1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DTX1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTX1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTX1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTX1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTX1
     GenScript Custom Purified and Recombinant Proteins Services for DTX1 GenScript cDNA clones with any tag delivered in your preferred vector for DTX1
     GenScript Custom Assay Services for DTX1 GenScript Custom Superior Antibodies Services for DTX1
     GenScript Custom overexpressing Cell Line Services for DTX1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DTX1 promoter
     Search Chromatin IP Primers for DTX1
     RT2 qPCR Primer Assay in human, mouse, rat DTX1
     Search GNC Networks for DTX1
     SABiosciences PCR Arrays including human, mouse, rat DTX1
     Search Tocris compounds for DTX1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DTX1 antibodies
     DTX1 proteins
     Antibodies for DTX1
     See all of Abcam's Antibodies, Kits and Proteins for DTX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     DTX1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for DTX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX1
     SwitchGear 3'UTR luciferase reporter plasmids for DTX1
     SwitchGear Promoter luciferase reporter plasmids for DTX1
     ThermoFisher Antibody for DTX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      DTX1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4