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Aliases for DTX1 Gene

Aliases for DTX1 Gene

  • Deltex 1, E3 Ubiquitin Ligase 2 3
  • Protein Deltex-1 3 4
  • Deltex1 3 4
  • HDTX1 3 4
  • E3 Ubiquitin-Protein Ligase DTX1 3
  • Deltex Homolog 1 (Drosophila) 2
  • Deltex Homolog 1 3
  • EC 6.3.2.- 4
  • HDx-1 3

External Ids for DTX1 Gene

Summaries for DTX1 Gene

Entrez Gene Summary for DTX1 Gene

  • Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for DTX1 Gene

DTX1 (Deltex 1, E3 Ubiquitin Ligase) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include transcription coactivator activity and SH3 domain binding. An important paralog of this gene is DTX4.

UniProtKB/Swiss-Prot for DTX1 Gene

  • Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

Gene Wiki entry for DTX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX1 Gene

Genomics for DTX1 Gene

Genomic Location for DTX1 Gene

Start:
113,056,709 bp from pter
End:
113,098,028 bp from pter
Size:
41,320 bases
Orientation:
Plus strand

Genomic View for DTX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX1 Gene

Regulatory Elements for DTX1 Gene

Proteins for DTX1 Gene

  • Protein details for DTX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y01-DTX1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase DTX1
    Protein Accession:
    Q86Y01
    Secondary Accessions:
    • O60630
    • Q9BS04

    Protein attributes for DTX1 Gene

    Size:
    620 amino acids
    Molecular mass:
    67368 Da
    Quaternary structure:
    • Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 via its N-terminal region and EIF3F, the interaction is required for NOTCH1 deubiquitination. Interacts with EP300. Forms a heterodimer with BBAP; the heterodimerization leading to an increase of in vitro ubiquitin ligase activity. Interacts with ITCH.

neXtProt entry for DTX1 Gene

Proteomics data for DTX1 Gene at MOPED

Post-translational modifications for DTX1 Gene

  • Ubiquitinated; undergoes Lys-29-linked polyubiquitination catalyzed by ITCH.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTX1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DTX1 Gene

Domains for DTX1 Gene

Protein Domains for DTX1 Gene

UniProtKB/Swiss-Prot:

DTX1_HUMAN
Domain:
  • The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.:
    • Q86Y01
  • Contains 2 WWE domains.:
    • Q86Y01
Family:
  • Belongs to the Deltex family.:
    • Q86Y01
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q86Y01
genes like me logo Genes that share domains with DTX1: view

No data available for Gene Families for DTX1 Gene

Function for DTX1 Gene

Molecular function for DTX1 Gene

UniProtKB/Swiss-Prot Function: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
UniProtKB/Swiss-Prot Induction: Regulated by NOTCH2.

Enzyme Numbers (IUBMB) for DTX1 Gene

Gene Ontology (GO) - Molecular Function for DTX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 9590294
GO:0005112 Notch binding IDA 11564735
GO:0005515 protein binding IPI 17028573
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with DTX1: view
genes like me logo Genes that share phenotypes with DTX1: view

Animal Models for DTX1 Gene

MGI Knock Outs for DTX1:

miRNA for DTX1 Gene

miRTarBase miRNAs that target DTX1

No data available for Transcription Factor Targeting and HOMER Transcription for DTX1 Gene

Localization for DTX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX1 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTX1 Gene COMPARTMENTS Subcellular localization image for DTX1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DTX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 9590294
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DTX1: view

Pathways for DTX1 Gene

genes like me logo Genes that share pathways with DTX1: view

UniProtKB/Swiss-Prot Q86Y01-DTX1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DTX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated NAS 11564735
GO:0006366 transcription from RNA polymerase II promoter TAS 9590294
GO:0007166 cell surface receptor signaling pathway TAS 9590294
GO:0007219 Notch signaling pathway TAS --
GO:0008593 regulation of Notch signaling pathway IGI 11564735
genes like me logo Genes that share ontologies with DTX1: view

Transcripts for DTX1 Gene

Unigene Clusters for DTX1 Gene

Deltex homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTX1 Gene

No ASD Table

Relevant External Links for DTX1 Gene

GeneLoc Exon Structure for
DTX1
ECgene alternative splicing isoforms for
DTX1

Expression for DTX1 Gene

mRNA expression in normal human tissues for DTX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DTX1 Gene

SOURCE GeneReport for Unigene cluster for DTX1 Gene Hs.372152

mRNA Expression by UniProt/SwissProt for DTX1 Gene

Q86Y01-DTX1_HUMAN
Tissue specificity: Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
genes like me logo Genes that share expressions with DTX1: view

Orthologs for DTX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTX1 36
  • 97.31 (n)
  • 96.93 (a)
DTX1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DTX1 36
  • 92.89 (n)
  • 97.25 (a)
DTX1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtx1 36
  • 87.8 (n)
  • 95.97 (a)
Dtx1 16
Dtx1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DTX1 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTX1 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtx1 36
  • 88.55 (n)
  • 96.29 (a)
chicken
(Gallus gallus)
Aves DTX1 36
  • 80.34 (n)
  • 84.02 (a)
DTX1 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTX1 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dtx 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dtx1 36
  • 68.19 (n)
  • 78.14 (a)
zebrafish
(Danio rerio)
Actinopterygii DTX1 37
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dx 37
  • 22 (a)
OneToMany
dx 38
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7641 37
  • 30 (a)
OneToMany
Species with no ortholog for DTX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX1 Gene

ENSEMBL:
Gene Tree for DTX1 (if available)
TreeFam:
Gene Tree for DTX1 (if available)

Paralogs for DTX1 Gene

Paralogs for DTX1 Gene

Selected SIMAP similar genes for DTX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DTX1: view

Variants for DTX1 Gene

Sequence variations from dbSNP and Humsavar for DTX1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs731570 -- 113,059,814(+) CTACT(A/T)AAATT intron-variant
rs733174 -- 113,060,540(-) TCTGC(C/T)CCTTC intron-variant
rs737633 -- 113,066,920(-) ATGCG(A/G)GACCT intron-variant
rs936386 -- 113,065,366(-) CACCC(A/G)GCTGC intron-variant
rs1074161 -- 113,081,938(-) CAGCA(C/T)CAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTX1 Gene

Variant ID Type Subtype PubMed ID
nsv519540 CNV Gain+Loss 19592680
nsv899525 CNV Loss 21882294
dgv1493n71 CNV Loss 21882294
nsv899527 CNV Loss 21882294
nsv899528 CNV Loss 21882294
esv259551 OTHER Complex 20981092
esv260035 OTHER Complex 20981092

Relevant External Links for DTX1 Gene

HapMap Linkage Disequilibrium report
DTX1
Human Gene Mutation Database (HGMD)
DTX1

Disorders for DTX1 Gene

No disorders were found for DTX1 Gene.

No data available for UniProtKB/Swiss-Prot for DTX1 Gene

Publications for DTX1 Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K. … Shipp M.A. (J. Biol. Chem. 2003) 2 3 4 23
  2. Human deltex is a conserved regulator of Notch signalling. (PMID: 9590294) Matsuno K. … Artavanis-Tsakonas S. (Nat. Genet. 1998) 2 3 4
  3. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. (PMID: 11564735) Yamamoto N. … Nakafuku M. (J. Biol. Chem. 2001) 3 4 23
  4. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. (PMID: 12753744) Saito T. … Hirai H. (Immunity 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DTX1 Gene

Sources for DTX1 Gene

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