Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DTX1 Gene

protein-coding   GIFtS: 59
GCID: GC12P113495

Deltex 1, E3 Ubiquitin Ligase

(Previous name: deltex homolog 1 (Drosophila))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Deltex 1, E3 Ubiquitin Ligase1 2     deltex12
Protein Deltex-12 3     E3 Ubiquitin-Protein Ligase DTX12
hDTX12 3     hDx-12
Deltex Homolog 1 (Drosophila)1     Deltex13
Deltex Homolog 12     EC 6.3.2.-3

External Ids:    HGNC: 30601   Entrez Gene: 18402   Ensembl: ENSG000001351447   OMIM: 6025825   UniProtKB: Q86Y013   

Export aliases for DTX1 gene to outside databases

Previous GC identifers: GC12P112390 GC12P113014 GC12P113278 GC12P111907 GC12P111958 GC12P110508


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DTX1 Gene:
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway.
The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix
transcription factor activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for DTX1 Gene:
DTX1 (deltex 1, E3 ubiquitin ligase) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and SH3 domain binding. An important paralog of this gene is DTX4.

UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01
Function: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of
MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad
spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a
negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch,
possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis
and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell
development at the expense of T-cell development, suggesting that it can antagonize NOTCH1

Gene Wiki entry for DTX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DTX1 gene promoter:
         Max1   AhR   Sox5   p53   AML1a   RORalpha2   Arnt   Ik-2   Sox9   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DTX1 promoter sequence
   Search Chromatin IP Primers for DTX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24

DTX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTX1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113495:  view genomic region     (about GC identifiers)

Start:
113,494,514 bp from pter      End:
113,535,833 bp from pter
Size:
41,320 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase DTX1  
Size: 620 amino acids; 67368 Da
Subunit: Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 via its
N-terminus region and EIF3F, the interaction is required for NOTCH1 deubiquitination. Interacts with EP300. Forms
a heterodimer with BBAP; the heterodimerization leading to an increase of in vitro ubiquitin ligase activity.
Interacts with ITCH
Secondary accessions: O60630 Q9BS04

Explore the universe of human proteins at neXtProt for DTX1: NX_Q86Y01

Explore proteomics data for DTX1 at MOPED

Post-translational modifications: 

  • Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DTX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004407.2  
    ENSEMBL proteins: 
     ENSP00000257600  
    Reactome Protein details: Q86Y01

    DTX1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DTX1
    GenScript Custom Purified and Recombinant Proteins Services for DTX1
    Novus Biologicals DTX1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DTX1

     
    Search eBioscience for Proteins for DTX1 

    DTX1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DTX1
    OriGene Antibodies for DTX1
    OriGene Custom Antibody Services for DTX1
    Novus Biologicals DTX1 Antibody
    Abcam antibodies for DTX1
    Cloud-Clone Corp. Antibodies for DTX1
    ThermoFisher Antibody for DTX1
    LSBio Antibodies in human, mouse, rat for DTX1

    DTX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DTX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DTX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DTX1
    Cloud-Clone Corp. CLIAs for DTX1
    Search eBioscience for ELISAs for DTX1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR004170 WWE-dom
     IPR018123 WWE-dom_subgr
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q86Y01

    ProtoNet protein and cluster: Q86Y01

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01
    Domain: The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in
    ubiquitin ligases (By similarity)
    Similarity: Belongs to the Deltex family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 WWE domains


    Find genes that share domains with DTX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DTX1_HUMAN, Q86Y01
    Function: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of
    MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).
    Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad
    spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a
    negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch,
    possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis
    and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell
    development at the expense of T-cell development, suggesting that it can antagonize NOTCH1
    Induction: Regulated by NOTCH2

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS9590294
    GO:0005112Notch binding IDA11564735
    GO:0005515protein binding IPI17028573
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    Find genes that share ontologies with DTX1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DTX1:
     Big cells 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dtx1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     normal  renal/urinary system  respiratory system 

    Find genes that share phenotypes with DTX1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DTX1: Dtx1tm1Crey Dtx1tm1.2Mzl Dtx1tm1Mjb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DTX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DTX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DTX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DTX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DTX1:
    hsa-mir-335-5p (MIRT017334), hsa-mir-1 (MIRT023569)

    Block miRNA regulation of human, mouse, rat DTX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DTX1 (see all 32):
    hsa-miR-194* hsa-miR-219-1-3p hsa-miR-1321 hsa-miR-765 hsa-miR-128 hsa-miR-1276 hsa-miR-629* hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidDTX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DTX1
    Predesigned siRNA for gene silencing in human, mouse, rat DTX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DTX1

    Clone
    Products:
         
    OriGene clones in human, mouse for DTX1 (see all 7)
    OriGene ORF clones in mouse, rat for DTX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DTX1 (NM_004416)
    Sino Biological Human cDNA Clone for DTX1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DTX1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DTX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DTX1_HUMAN, Q86Y01: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles.
    Partially nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS9590294
    GO:0005829cytosol TAS--

    Find genes that share ontologies with DTX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DTX1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    Notch Signaling Pathway0.84
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH0.64
    3Signaling by NOTCH2
    Activated NOTCH1 Transmits Signal to the Nucleus0.61
    4Signaling by GPCR
    Signal Transduction0.58
    5Presenilin action in Notch and Wnt signaling
    Presenilin action in Notch and Wnt signaling


    Find genes that share SuperPaths with DTX1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for DTX1
        Notch Signaling Pathway
    Delta-Notch Signaling Pathway
    Presenilin action in Notch and Wnt signaling
    Notch signaling pathway


    1 Reactome Pathway for DTX1
        Activated NOTCH1 Transmits Signal to the Nucleus


    1 Kegg Pathway  (Kegg details for DTX1):
        Notch signaling pathway

    UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DTX1: 

              Notch Signaling Targets in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DTX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DTX1 (Q86Y011, 2, 3 ENSP000002576004) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-3381104 MINT-3381037 I2D: score=2 STRING: ENSP00000363998
    UBCP0CG481, 2, 3, ENSP000003448184EBI-1755174,EBI-3390054 MINT-3381152 MINT-3381175 I2D: score=1 STRING: ENSP00000344818
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated NAS11564735
    GO:0006366transcription from RNA polymerase II promoter TAS9590294
    GO:0007166cell surface receptor signaling pathway TAS9590294
    GO:0007219Notch signaling pathway TAS--
    GO:0008593regulation of Notch signaling pathway IGI11564735

    Find genes that share ontologies with DTX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DTX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DTX1 gene: 
    NM_004416.2  

    Unigene Cluster for DTX1:

    Deltex homolog 1 (Drosophila)
    Hs.372152  [show with all ESTs]
    Unigene Representative Sequence: NM_004416
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548759 ENST00000257600(uc001tuk.1) ENST00000547974 ENST00000553140
    ENST00000547730
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DTX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DTX1 (see all 32):
    hsa-miR-194* hsa-miR-219-1-3p hsa-miR-1321 hsa-miR-765 hsa-miR-128 hsa-miR-1276 hsa-miR-629* hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidDTX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DTX1
    Predesigned siRNA for gene silencing in human, mouse, rat DTX1
    Clone
    Products:
         
    OriGene clones in human, mouse for DTX1 (see all 7)
    OriGene ORF clones in mouse, rat for DTX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DTX1 (NM_004416)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DTX1
    OriGene qSTAR qPCR primer pairs in human, mouse for DTX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTX1
      QuantiTect SYBR Green Assays in human, mouse, rat DTX1
      QuantiFast Probe-based Assays in human, mouse, rat DTX1

    Additional mRNA sequence: 

    AF053700.1 BC005816.2 BC008321.1 BC048216.1 

    6 DOTS entries:

    DT.411502  DT.409220  DT.92420400  DT.40191795  DT.86855175  DT.92420401 

    Selected AceView cDNA sequences (see all 87):

    AW408836 BQ057477 CR620865 NM_004416 AA721092 BC005816 AW408513 AA810980 
    BX281251 BU726168 AW291600 BQ061257 BE396937 N62052 BX350250 AW504380 
    AW403335 AF053700 BC008321 AW837772 AW408687 BX349022 BM685791 AI364722 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DTX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTGGAAGC
    DTX1 Expression
    About this image


    DTX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
    DTX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DTX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.372152

    UniProtKB/Swiss-Prot: DTX1_HUMAN, Q86Y01
    Tissue specificity: Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous
    system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and
    T-cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DTX1: 
              Notch Signaling Targets in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DTX1
    OriGene qSTAR qPCR primer pairs in human, mouse for DTX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTX1
    QuantiTect SYBR Green Assays in human, mouse, rat DTX1
    QuantiFast Probe-based Assays in human, mouse, rat DTX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DTX1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtx11 , 5 deltex 1 homolog (Drosophila)1, 5 87.8(n)1
    95.97(a)1
      5 (60.64 cM)5
    143571  NM_008052.31  NP_032078.21 
     1206802025 
    chicken
    (Gallus gallus)
    Aves DTX11 deltex homolog 1 (Drosophila) 80.34(n)
    84.02(a)
      770657  XM_001233993.3  XP_001233994.2 
    lizard
    (Anolis carolinensis)
    Reptilia DTX16
    deltex homolog 1 (Drosophila)
    83(a)
    1 ↔ 1
    GL343338.1(729223-752994)
    African clawed frog
    (Xenopus laevis)
    Amphibia dtx2 hypothetical protein 74.7(n)    AJ431211.1 
    zebrafish
    (Danio rerio)
    Actinopterygii DTX16
    deltex homolog 1 (Drosophila)
    78(a)
    1 ↔ 1
    Zv9_NA771(12736-43326) ENSDARG00000062840
    fruit fly
    (Drosophila melanogaster)
    Insecta dx3 N receptor signaling pathway SH3-domain
    binding
    42(a)     --


    ENSEMBL Gene Tree for DTX1 (if available)
    TreeFam Gene Tree for DTX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DTX1 gene
    DTX42  DTX3L2  DTX32  DTX22  
    2 SIMAP similar genes for DTX1 using alignment to 1 protein entry:     DTX1_HUMAN:
    DTX4    DTX2

    Find genes that share paralogs with DTX1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DTX1 (see all 892)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1177412381,2
    F--113493692(+) CCCCCC/GTCCCA 1 -- us2k11Minor allele frequency- G:0.07NA 120
    rs1924950941,2
    --113493734(+) CTGGAA/GGACAG 1 -- us2k10--------
    rs1839278221,2
    --113493846(+) CAGGTG/TGCTGT 1 -- us2k10--------
    rs73065761,2
    C,F--113493916(+) GTCCCC/TTCCCC 1 -- us2k1 tfbs3 trp38Minor allele frequency- T:0.07WA CSA NA EA 367
    rs1444601741,2
    --113494010(+) TCAGAC/TCGGGG 1 -- us2k10--------
    rs734277181,2
    C,F--113494012(+) AGATCG/AGGGTT 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1859014691,2
    --113494044(+) GCTTTC/TGTGAT 1 -- us2k10--------
    rs22547701,2
    C,F,H--113494323(-) GTCACC/GGGCTT 1 -- us2k117Minor allele frequency- G:0.19NS EA NA 2222
    rs1395474881,2
    C--113494610(+) GGAAA-/TTTC  
            
    GCTCG
    1 -- us2k10--------
    rs1898010141,2
    --113494759(+) GAACGA/CGGGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DTX1 (113494514 - 113535833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DTX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899527CNV Loss21882294
    dgv1493n71CNV Loss21882294
    nsv899528CNV Loss21882294
    nsv899525CNV Loss21882294
    nsv519540CNV Gain+Loss19592680
    esv259551OTHER Complex20981092
    esv260035OTHER Complex20981092

    Human Gene Mutation Database (HGMD): DTX1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DTX1
    DNA2.0 Custom Variant and Variant Library Synthesis for DTX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602582    OMIM disorders: --


    Find genes that share disorders with DTX1           About GenesLikeMe


    Export disorders for DTX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DTX1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with DTX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PubMed id 12670957)1, 2, 3, 9 Takeyama K.... Shipp M.A. (J. Biol. Chem. 2003)
    2. Human deltex is a conserved regulator of Notch signalling. (PubMed id 9590294)1, 2, 3 Matsuno K.... Artavanis-Tsakonas S. (Nat. Genet. 1998)
    3. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. (PubMed id 11564735)1, 2, 9 Yamamoto N....Nakafuku M. (J. Biol. Chem. 2001)
    4. The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. (PubMed id 21124883)1, 2 Moretti J.... Brou C. (PLoS Biol. 2010)
    5. Itch/AIP4 mediates Deltex degradation through the formation of K29- linked polyubiquitin chains. (PubMed id 17028573)1, 2 Chastagner P.... Brou C. (EMBO Rep. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. (PubMed id 12753744)1, 2 Saito T.... Hirai H. (Immunity 2003)
    8. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. (PubMed id 11869684)1, 2 Izon D.J.... Pear W.S. (Immunity 2002)
    9. Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy. (PubMed id 19592273)1, 9 Hsiao H.W....Lai M.Z. (Immunity 2009)
    10. New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP). (PubMed id 23395680)1 Zencir S....Mohanty S. (Biochem. Biophys. Res. Commun. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1840 HGNC: 3060 AceView: DTX1 Ensembl:ENSG00000135144 euGenes: HUgn1840
    ECgene: DTX1 Kegg: 1840 H-InvDB: DTX1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DTX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DTX1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DTX1 gene:
    Search GeneIP for patents involving DTX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for DTX1 (DTX1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DTX1   OriGene RNAi products in human, mouse, rat for DTX1  
     OriGene qPCR primer pairs and template standards for DTX1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DTX1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DTX1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DTX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DTX1   OriGene Custom Protein Services for DTX1  

     
     
     Block miRNA regulation of human, mouse, rat DTX1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DTX1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTX1 Predesigned siRNA for gene silencing in human, mouse, rat DTX1
     QuantiFast Probe-based Assays in human, mouse, rat DTX1 QuantiTect SYBR Green Assays in human, mouse, rat DTX1
     PCR Arrays including human, mouse, rat DTX1 Search Chromatin IP Primers for DTX1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTX1  Search GeneGlobe Interaction Network for DTX1
     Regulatory tfbs in DTX1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DTX1 GenScript cDNA clones with any tag delivered in your preferred vector for DTX1
     GenScript Custom Assay Services for DTX1 GenScript Custom overexpressing Cell Line Services for DTX1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DTX1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DTX1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DTX1 antibodies
     DTX1 proteins
     Antibodies for DTX1
     See all of Abcam's Antibodies, Kits and Proteins for DTX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DTX1
     Antibodies for DTX1
     ELISAs for DTX1
     CLIAs for DTX1



     Browse ESI BIO Cell Lines and PureStem Progenitors for DTX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTX1
     SwitchGear 3'UTR luciferase reporter plasmids for DTX1
     SwitchGear Promoter luciferase reporter plasmids for DTX1
     ThermoFisher Antibody for DTX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTX1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DTX1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DTX1
     LSBio Antibodies in human, mouse, rat for DTX1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DTX1
      Search eBioscience for proteins for DTX1
      Search eBioscience for elisas for DTX1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DTX1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4