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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DTWD2 Gene

protein-coding   GIFtS: 38
GCID: GC05M118205

DTW domain containing 2
  Search for DTWD2
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DTWD2    

Aliases
for DTWD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DTW Domain Containing 21 2
FLJ339771
DTW Domain-Containing Protein 22

External Ids:    HGNC: 193341   Entrez Gene: 2856052   Ensembl: ENSG000001695707   UniProtKB: Q8NBA83   

Export aliases for DTWD2 gene to outside databases

Previous GC identifer: GC05M113359


Summaries
for DTWD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for DTWD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DTWD2 gene promoter:
         FOXD3   Olf-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Cdc5   POU3F2   S8   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DTWD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DTWD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTWD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23.1

DTWD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTWD2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M118205:  view genomic region     (about GC identifiers)

Start:
 118,172,569 bp from pter      End:
 118,324,240 bp from pter
Size:
 151,672 bases      Orientation:
 minus strand

Proteins
for DTWD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DTWD2_HUMAN, Q8NBA8 (See protein sequence)
Recommended Name: DTW domain-containing protein 2  
Size: 298 amino acids; 33416 Da

Explore the universe of human proteins at neXtProt for DTWD2: NX_Q8NBA8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NBA8

    • DTWD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_775937.1  
    ENSEMBL proteins: 
     ENSP00000302892   ENSP00000425048   ENSP00000425016   ENSP00000424221  

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    Protein Domains /
    Families
    for DTWD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DTWD2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005636 DTW

    Graphical View of Domain Structure for InterPro Entry Q8NBA8

    ProtoNet protein and cluster: Q8NBA8

    UniProtKB/Swiss-Prot: DTWD2_HUMAN, Q8NBA8
    Domain: Contains 1 DXTW motif
    Similarity: Belongs to the DTW family


    Function
    for DTWD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DTWD2
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate DTWD2 (see all 17):
    hsa-miR-3164 hsa-miR-29a hsa-miR-29c hsa-miR-138-2* hsa-miR-3658 hsa-miR-889 hsa-miR-3613-3p hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmid: DTWD2 3' UTR sequence
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    Pathways & Interactions
    for DTWD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DTWD2

    Drugs & Compounds
    for DTWD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DTWD2
    Search CenterWatch for drugs/clinical trials and news about DTWD2 

    Transcripts
    for DTWD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DTWD2 gene: 
    NM_173666.2  

    Unigene Cluster for DTWD2:

    DTW domain containing 2
    Hs.655891  [show with all ESTs]
    Unigene Representative Sequence: NM_173666
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304058(uc003ksa.3) ENST00000510708 ENST00000506980 ENST00000515439


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    hsa-miR-3164 hsa-miR-29a hsa-miR-29c hsa-miR-138-2* hsa-miR-3658 hsa-miR-889 hsa-miR-3613-3p hsa-miR-205*
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK091296.1 AK124328.1 BC012294.1 BC114508.1 BC114955.1 BX648369.1 

    2 DOTS entries:

    DT.100019712  DT.411702 

    24/48 AceView cDNA sequences (see all 48):

    BE897236 BI060701 BM821425 BQ441240 NM_173666 BG036510 BG036517 AI078436 
    AW009893 AX746901 AI078432 BC012294 CA393433 BE536383 BU858313 AK091296 
    BG285123 BX648369 AA436607 AK124328 AI347604 BU175844 BG182620 BG286654 

    GeneLoc Exon Structure


    Expression
    for DTWD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DTWD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DTWD2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DTWD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DTWD2

    SOURCE GeneReport for Unigene cluster: Hs.655891
        SABiosciences Custom PCR Arrays for DTWD2
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTWD2

    Orthologs
    for DTWD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DTWD2 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dtwd21 , 5 DTW domain containing 21, 5 85.46(n)1
    84.56(a)1    		   18 (27.09 cM)5
    688571  NM_026854.31  NP_081130.11 
     496968145 
    chicken
    (Gallus gallus)    		 Aves DTWD21 DTW domain containing 2 75.32(n)
    77.91(a)    		   427386  NM_001031442.1  NP_001026613.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DTWD26
    		 --
    		 79(a)
    		 1 ↔ 1
    		 GL343193.1(10228165-10334468)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.177042 Transcribed sequences 78.98(n)    AL773776.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005378371 DTW domain-containing protein 2-like 60(n)
    64.8(a)    		   100537837  XM_003200799.1  XP_003200847.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG100501 CG10050 47.96(n)
    43.46(a)    		   40873  NM_141456.3  NP_649713.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G417501 DTW domain-containing protein 42.93(n)
    30.37(a)    		   818774  NM_129739.3  NP_181706.1 
    rice
    (Oryza sativa)    		 Liliopsida Os12g01426001 hypothetical protein 46.07(n)
    36.44(a)    		   4351476  NM_001072664.1  NP_001066132.1 


    ENSEMBL Gene Tree for DTWD2 (if available)
    TreeFam Gene Tree for DTWD2 (if available) 

    Paralogs
    for DTWD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DTWD2 gene

    DTWD2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DTWD2
    PGOHUM00000237032


    Genomic Variants
    for DTWD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2684 NCBI SNPs in DTWD2 are shown (see all 2684)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1494635241,2
    		--118172170(+) CTCGTC/GATCTA 1 -- ds50010--------
    rs68619071,2
    		C,F,A,H,--118172345(+) TCACAG/TGTTGA 1 -- ds500112Minor allele frequency- T:0.33NS EA NA WA CSA 786
    rs1907227671,2
    		--118172364(+) TTCCCA/GAGGTA 1 -- ds50010--------
    rs1928089591,2
    		--118172394(+) CTTTGA/GGGGAT 1 -- ds50010--------
    rs1845660561,2
    		--118172433(+) AGCTCA/GACCCT 1 -- ds50010--------
    rs1886363571,2
    		--118172650(+) AGCACA/GGTGTA 1 -- ut310--------
    rs1471577691,2
    		--118172696(+) TTAAAC/TATAAA 1 -- ut310--------
    rs1404123671,2
    		--118172717(+) GTTAAA/GACCAC 1 -- ut310--------
    rs1813723241,2
    		--118172838(+) GTAGGC/TGATGA 1 -- ut310--------
    rs1165923571,2
    		F,--118172852(+) AGGGAG/AAGGAA 1 -- ut312Minor allele frequency- A:0.04WA NA 238

    HapMap Linkage Disequilibrium report for DTWD2 (118172569 - 118324240 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DTWD2
         1 CNV: 99275

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    Disorders / Diseases
    for DTWD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DTWD2 for disorders           About MalaCards

    DTWD2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: DTWD2 (2 documents)

    Export disorders for DTWD2 gene to outside databases

    Publications
    for DTWD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DTWD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DTWD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions. (PubMed id 1612591)1 Manrow R.E....Berger S.L. (1992)
    8. Isolation and partial sequencing of the human prothymosin alpha gene family. Evidence against export of the gene products. (PubMed id 2708378)1 Eschenfeldt W.H.... Berger S.L. (1989)

    External Searches for DTWD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DTWD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285605 HGNC: 19334 AceView: FLJ33977 Ensembl:ENSG00000169570 euGenes: HUgn285605
    ECgene: DTWD2 H-InvDB: DTWD2

    Other Databases showing DTWD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DTWD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DTWD2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DTWD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DTWD2 gene:
    Search GeneIP for patents involving DTWD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DTWD2 gene

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    About This Section

     
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