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Aliases for DTWD2 Gene

Aliases for DTWD2 Gene

  • DTW Domain Containing 2 2 3 5

External Ids for DTWD2 Gene

Previous GeneCards Identifiers for DTWD2 Gene

  • GC05M118205
  • GC05M113359

Summaries for DTWD2 Gene

GeneCards Summary for DTWD2 Gene

DTWD2 (DTW Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTWD2 Gene

Genomics for DTWD2 Gene

Regulatory Elements for DTWD2 Gene

Enhancers for DTWD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DTWD2 on UCSC Golden Path with GeneCards custom track

Promoters for DTWD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DTWD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DTWD2 Gene

118,836,074 bp from pter
118,988,545 bp from pter
152,472 bases
Minus strand

Genomic View for DTWD2 Gene

Genes around DTWD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTWD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTWD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTWD2 Gene

Proteins for DTWD2 Gene

  • Protein details for DTWD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DTW domain-containing protein 2
    Protein Accession:

    Protein attributes for DTWD2 Gene

    298 amino acids
    Molecular mass:
    33416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DTWD2 Gene

Proteomics data for DTWD2 Gene at MOPED

Post-translational modifications for DTWD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTWD2 Gene

No data available for DME Specific Peptides for DTWD2 Gene

Domains & Families for DTWD2 Gene

Protein Domains for DTWD2 Gene


Suggested Antigen Peptide Sequences for DTWD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DXTW motif.
  • Belongs to the DTW family.
  • Contains 1 DXTW motif.
  • Belongs to the DTW family.
genes like me logo Genes that share domains with DTWD2: view

No data available for Gene Families for DTWD2 Gene

Function for DTWD2 Gene

genes like me logo Genes that share phenotypes with DTWD2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTWD2 Gene

Localization for DTWD2 Gene

Subcellular locations from

Jensen Localization Image for DTWD2 Gene COMPARTMENTS Subcellular localization image for DTWD2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DTWD2 Gene

Pathways & Interactions for DTWD2 Gene

SuperPathways for DTWD2 Gene

No Data Available

Interacting Proteins for DTWD2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000425048 for DTWD2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for DTWD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for DTWD2 Gene

Drugs & Compounds for DTWD2 Gene

No Compound Related Data Available

Transcripts for DTWD2 Gene

Unigene Clusters for DTWD2 Gene

DTW domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTWD2 Gene

No ASD Table

Relevant External Links for DTWD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DTWD2 Gene

mRNA expression in normal human tissues for DTWD2 Gene

Protein differential expression in normal tissues from HIPED for DTWD2 Gene

This gene is overexpressed in Lung (46.5) and Pancreas (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DTWD2 Gene

SOURCE GeneReport for Unigene cluster for DTWD2 Gene Hs.655891

genes like me logo Genes that share expression patterns with DTWD2: view

Protein tissue co-expression partners for DTWD2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DTWD2 Gene

Orthologs for DTWD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTWD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DTWD2 35
  • 88.81 (n)
  • 88.59 (a)
DTWD2 36
  • 89 (a)
(Canis familiaris)
Mammalia DTWD2 35
  • 93.22 (n)
  • 96.02 (a)
-- 36
  • 83 (a)
-- 36
  • 81 (a)
(Mus musculus)
Mammalia Dtwd2 35
  • 85.46 (n)
  • 84.56 (a)
Dtwd2 16
Dtwd2 36
  • 85 (a)
(Pan troglodytes)
Mammalia DTWD2 35
  • 99.66 (n)
  • 99.66 (a)
DTWD2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dtwd2 35
  • 84.45 (n)
  • 84.23 (a)
(Monodelphis domestica)
Mammalia DTWD2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia DTWD2 36
  • 71 (a)
(Gallus gallus)
Aves DTWD2 35
  • 76.5 (n)
  • 81.15 (a)
DTWD2 36
  • 76 (a)
(Anolis carolinensis)
Reptilia DTWD2 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dtwd2 35
  • 70.48 (n)
  • 77.55 (a)
Str.17704 35
(Danio rerio)
Actinopterygii si:zfos-1462c8.5 35
  • 59.97 (n)
  • 65.57 (a)
DTWD2 36
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3789 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001801 35
  • 45.31 (n)
  • 42.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10050 35
  • 48.28 (n)
  • 43.97 (a)
CG10050 36
  • 41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G41750 35
  • 44.5 (n)
  • 31.38 (a)
(Oryza sativa)
Liliopsida Os12g0142600 35
  • 47.22 (n)
  • 38.89 (a)
Species with no ortholog for DTWD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTWD2 Gene

Gene Tree for DTWD2 (if available)
Gene Tree for DTWD2 (if available)

Paralogs for DTWD2 Gene Pseudogenes for DTWD2 Gene

genes like me logo Genes that share paralogs with DTWD2: view

No data available for Paralogs for DTWD2 Gene

Variants for DTWD2 Gene

Sequence variations from dbSNP and Humsavar for DTWD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs727029 -- 118,989,285(-) TCATT(C/T)TAACA upstream-variant-2KB
rs10768 -- 118,837,432(+) TTAGA(A/T)CTGAC utr-variant-3-prime
rs764074 -- 118,989,277(-) ACATA(A/G)ATTTC upstream-variant-2KB
rs767935 -- 118,907,348(-) TCTCT(A/C/T)TATAT intron-variant
rs822743 -- 118,854,886(+) TATAT(G/T)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTWD2 Gene

Variant ID Type Subtype PubMed ID
nsv882767 CNV Loss 21882294
dgv6305n71 CNV Loss 21882294
esv2557297 CNV Deletion 19546169
nsv526318 CNV Loss 19592680
nsv823191 CNV Loss 20364138
esv2666628 CNV Deletion 23128226

Variation tolerance for DTWD2 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DTWD2 Gene

Disorders for DTWD2 Gene

Relevant External Links for DTWD2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DTWD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTWD2 Gene

Publications for DTWD2 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association studies of maximum number of drinks. (PMID: 23953852) Pan Y. … Wang K.S. (J Psychiatr Res 2013) 3
  4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3

Products for DTWD2 Gene

Sources for DTWD2 Gene