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DTWD2 Gene

protein-coding   GIFtS: 42
GCID: GC05M118205

DTW Domain Containing 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DTW Domain Containing 21 2
DTW Domain-Containing Protein 22

External Ids:    HGNC: 193341   Entrez Gene: 2856052   Ensembl: ENSG000001695707   UniProtKB: Q8NBA83   

Export aliases for DTWD2 gene to outside databases

Previous GC identifer: GC05M113359


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DTWD2 Gene:
DTWD2 (DTW domain containing 2) is a protein-coding gene. Diseases associated with DTWD2 include malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the DTWD2 gene promoter:
         FOXD3   Olf-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Cdc5   POU3F2   S8   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDTWD2 promoter sequence
   Search Chromatin IP Primers for DTWD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTWD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23.1

DTWD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTWD2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M118205:  view genomic region     (about GC identifiers)

Start:
118,172,569 bp from pter      End:
118,324,240 bp from pter
Size:
151,672 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DTWD2_HUMAN, Q8NBA8 (See protein sequence)
Recommended Name: DTW domain-containing protein 2  
Size: 298 amino acids; 33416 Da

Explore the universe of human proteins at neXtProt for DTWD2: NX_Q8NBA8

Explore proteomics data for DTWD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DTWD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775937.1  
    ENSEMBL proteins: 
     ENSP00000302892   ENSP00000425048   ENSP00000424221   ENSP00000425016  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005636 DTW

    Graphical View of Domain Structure for InterPro Entry Q8NBA8

    ProtoNet protein and cluster: Q8NBA8

    UniProtKB/Swiss-Prot: DTWD2_HUMAN, Q8NBA8
    Domain: Contains 1 DXTW motif
    Similarity: Belongs to the DTW family


    DTWD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DTWD2
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    hsa-miR-3164 hsa-miR-29a hsa-miR-29c hsa-miR-138-2* hsa-miR-3658 hsa-miR-889 hsa-miR-3613-3p hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidDTWD2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DTWD2
    Interactions:

        Search GeneGlobe Interaction Network for DTWD2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DTWD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DTWD2 gene: 
    NM_173666.2  

    Unigene Cluster for DTWD2:

    DTW domain containing 2
    Hs.655891  [show with all ESTs]
    Unigene Representative Sequence: NM_173666
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304058(uc003ksa.3) ENST00000510708 ENST00000515439 ENST00000506980

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DTWD2 (see all 17):
    hsa-miR-3164 hsa-miR-29a hsa-miR-29c hsa-miR-138-2* hsa-miR-3658 hsa-miR-889 hsa-miR-3613-3p hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidDTWD2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat DTWD2

    Additional mRNA sequence: 

    AK091296.1 AK124328.1 BC012294.1 BC114508.1 BC114955.1 BX648369.1 

    2 DOTS entries:

    DT.100019712  DT.411702 

    Selected AceView cDNA sequences (see all 48):

    BI060701 BE897236 AW009893 AK124328 BG036510 BG036517 BU858313 AA436607 
    BC012294 BX648369 BQ441240 AI078436 AI078432 NM_173666 AX746901 BG285123 
    BE536383 AI347604 BU175844 CA393433 AK091296 BM821425 AL699903 CF145180 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DTWD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DTWD2 Expression
    About this image

    DTWD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DTWD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655891
        Custom PCR Arrays for DTWD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTWD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DTWD2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtwd21 , 5 DTW domain containing 21, 5 85.46(n)1
    84.56(a)1
      18 (27.09 cM)5
    688571  NM_026854.31  NP_081130.11 
     496968145 
    chicken
    (Gallus gallus)
    Aves DTWD21 DTW domain containing 2 76.5(n)
    81.15(a)
      427386  NM_001031442.1  NP_001026613.1 
    lizard
    (Anolis carolinensis)
    Reptilia DTWD26
    DTW domain containing 2
    72(a)
    1 ↔ 1
    GL343193.1(10224215-10334561)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.177042 Transcribed sequences 78.98(n)    AL773776.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:zfos-1462c8.51 si:zfos-1462c8.5 59.97(n)
    65.57(a)
      100537837  XM_003200799.2  XP_003200847.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100501 CG10050 48.28(n)
    43.97(a)
      40873  NM_141456.3  NP_649713.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G417501 AT2G41750 44.5(n)
    31.38(a)
      818774  NM_129739.3  NP_181706.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g01426001 Os12g0142600 47.22(n)
    38.89(a)
      4351476  NM_001072664.1  NP_001066132.1 


    ENSEMBL Gene Tree for DTWD2 (if available)
    TreeFam Gene Tree for DTWD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DTWD2 gene

    DTWD2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DTWD2
    PGOHUM00000237032


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DTWD2 (see all 3117)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494635241,2
    C--118172170(+) CTCGTC/GATCTA 1 -- ds50010--------
    rs68619071,2
    C,F,A,H--118172345(+) tcacaG/Tgttga 1 -- ds500112Minor allele frequency- T:0.33NS EA NA WA CSA 786
    rs1907227671,2
    --118172364(+) TTCCCA/GAGGTA 1 -- ds50010--------
    rs1928089591,2
    --118172394(+) CTTTGA/GGGGAT 1 -- ds50010--------
    rs1845660561,2
    --118172433(+) AGCTCA/GACCCT 1 -- ds50010--------
    rs1886363571,2
    C--118172650(+) AGCACA/GGTGTA 1 -- ut310--------
    rs1471577691,2
    --118172696(+) TTAAAC/TATAAA 1 -- ut310--------
    rs1404123671,2
    C--118172717(+) GTTAAA/GACCAC 1 -- ut310--------
    rs1813723241,2
    --118172838(+) GTAGGC/TGATGA 1 -- ut310--------
    rs1165923571,2
    C,F--118172852(+) AGGGAG/AAGGAA 1 -- ut312Minor allele frequency- A:0.04WA NA 238

    HapMap Linkage Disequilibrium report for DTWD2 (118172569 - 118324240 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DTWD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2557297CNV Deletion19546169
    esv2666628CNV Deletion23128226
    nsv882767CNV Loss21882294
    dgv6305n71CNV Loss21882294
    nsv823191CNV Loss20364138
    nsv526318CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DTWD2
    DNA2.0 Custom Variant and Variant Library Synthesis for DTWD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for DTWD2:    
    About MalaCards
    malaria


    DTWD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DTWD2
    Human Genome Epidemiology (HuGE) Navigator: DTWD2 (2 documents)

    Export disorders for DTWD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DTWD2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DTWD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions. (PubMed id 1612591)1 Manrow R.E....Berger S.L. (Genomics 1992)
    10. Isolation and partial sequencing of the human prothymosin alpha gene family. Evidence against export of the gene products. (PubMed id 2708378)1 Eschenfeldt W.H.... Berger S.L. (J. Biol. Chem. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285605 HGNC: 19334 AceView: FLJ33977 Ensembl:ENSG00000169570 euGenes: HUgn285605
    ECgene: DTWD2 H-InvDB: DTWD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DTWD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DTWD2 gene:
    Search GeneIP for patents involving DTWD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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