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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DTWD2 Gene

protein-coding   GIFtS: 38
GCID: GC05M118205

DTW Domain Containing 2

  Search for DTWD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DTW Domain Containing 21 2
DTW Domain-Containing Protein 22

External Ids:    HGNC: 193341   Entrez Gene: 2856052   Ensembl: ENSG000001695707   UniProtKB: Q8NBA83   

Export aliases for DTWD2 gene to outside databases

Previous GC identifer: GC05M113359


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DTWD2 Gene: 
DTWD2 (DTW domain containing 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DTWD2 gene promoter:
         FOXD3   Olf-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Cdc5   POU3F2   S8   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDTWD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DTWD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTWD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23.1

DTWD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTWD2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M118205:  view genomic region     (about GC identifiers)

Start:
118,172,569 bp from pter      End:
118,324,240 bp from pter
Size:
151,672 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DTWD2_HUMAN, Q8NBA8 (See protein sequence)
Recommended Name: DTW domain-containing protein 2  
Size: 298 amino acids; 33416 Da

Explore the universe of human proteins at neXtProt for DTWD2: NX_Q8NBA8

Explore proteomics data for DTWD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NBA8

  • DTWD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DTWD2 Protein Expression
    REFSEQ proteins: NP_775937.1  
    ENSEMBL proteins: 
     ENSP00000302892   ENSP00000425048   ENSP00000424221   ENSP00000425016  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005636 DTW

    Graphical View of Domain Structure for InterPro Entry Q8NBA8

    ProtoNet protein and cluster: Q8NBA8

    UniProtKB/Swiss-Prot: DTWD2_HUMAN, Q8NBA8
    Domain: Contains 1 DXTW motif
    Similarity: Belongs to the DTW family


    DTWD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DTWD2 
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    SwitchGear 3'UTR luciferase reporter plasmidDTWD2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DTWD2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DTWD2

    Search CenterWatch for drugs/clinical trials and news about DTWD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DTWD2 gene: 
    NM_173666.2  

    Unigene Cluster for DTWD2:

    DTW domain containing 2
    Hs.655891  [show with all ESTs]
    Unigene Representative Sequence: NM_173666
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304058(uc003ksa.3) ENST00000510708 ENST00000515439 ENST00000506980

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidDTWD2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTWD2

    Additional mRNA sequence: 

    AK091296.1 AK124328.1 BC012294.1 BC114508.1 BC114955.1 BX648369.1 

    2 DOTS entries:

    DT.100019712  DT.411702 

    24/48 AceView cDNA sequences (see all 48):

    BE897236 BI060701 AA436607 BG036517 CA393433 AI347604 NM_173666 AK124328 
    AW009893 AI078432 BQ441240 AK091296 BG036510 BG285123 BU175844 BE536383 
    AI078436 BC012294 BM821425 BU858313 AX746901 BX648369 CF145180 BQ267628 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DTWD2 expression in normal human tissues (normalized intensities)      DTWD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DTWD2 Expression
    About this image


    DTWD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Skeletal Muscle (Muscoskeletal System)
             gastrocnemius muscle   

    See DTWD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DTWD2

    SOURCE GeneReport for Unigene cluster: Hs.655891
        SABiosciences Custom PCR Arrays for DTWD2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTWD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DTWD2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtwd21 , 5 DTW domain containing 21, 5 85.46(n)1
    84.56(a)1
      18 (27.09 cM)5
    688571  NM_026854.31  NP_081130.11 
     496968145 
    chicken
    (Gallus gallus)
    Aves DTWD21 DTW domain containing 2 75.32(n)
    77.91(a)
      427386  NM_001031442.1  NP_001026613.1 
    lizard
    (Anolis carolinensis)
    Reptilia DTWD26
    Uncharacterized protein
    71(a)
    1 ↔ 1
    GL343193.1(10224215-10334561)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.177042 Transcribed sequences 78.98(n)    AL773776.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005378371 DTW domain-containing protein 2-like 60(n)
    64.8(a)
      100537837  XM_003200799.1  XP_003200847.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100501 CG10050 47.96(n)
    43.46(a)
      40873  NM_141456.3  NP_649713.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G417501 DTW domain-containing protein 42.93(n)
    30.37(a)
      818774  NM_129739.3  NP_181706.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g01426001 hypothetical protein 46.07(n)
    36.44(a)
      4351476  NM_001072664.1  NP_001066132.1 


    ENSEMBL Gene Tree for DTWD2 (if available)
    TreeFam Gene Tree for DTWD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DTWD2 gene

    DTWD2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DTWD2
    PGOHUM00000237032


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3117 SNPs in DTWD2 are shown (see all 3117)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494635241,2
    C--118172170(+) CTCGTC/GATCTA 1 -- ds50010--------
    rs68619071,2
    C,F,A,H--118172345(+) tcacaG/Tgttga 1 -- ds500112Minor allele frequency- T:0.33NS EA NA WA CSA 786
    rs1907227671,2
    --118172364(+) TTCCCA/GAGGTA 1 -- ds50010--------
    rs1928089591,2
    --118172394(+) CTTTGA/GGGGAT 1 -- ds50010--------
    rs1845660561,2
    --118172433(+) AGCTCA/GACCCT 1 -- ds50010--------
    rs1886363571,2
    C--118172650(+) AGCACA/GGTGTA 1 -- ut310--------
    rs1471577691,2
    --118172696(+) TTAAAC/TATAAA 1 -- ut310--------
    rs1404123671,2
    C--118172717(+) GTTAAA/GACCAC 1 -- ut310--------
    rs1813723241,2
    --118172838(+) GTAGGC/TGATGA 1 -- ut310--------
    rs1165923571,2
    C,F--118172852(+) AGGGAG/AAGGAA 1 -- ut312Minor allele frequency- A:0.04WA NA 238

    HapMap Linkage Disequilibrium report for DTWD2 (118172569 - 118324240 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DTWD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2557297CNV Deletion19546169
    esv2666628CNV Deletion23128226
    nsv882767CNV Loss21882294
    dgv6305n71CNV Loss21882294
    nsv823191CNV Loss20364138
    nsv526318CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DTWD2 for disorders           About MalaCards

    DTWD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DTWD2
    Human Genome Epidemiology (HuGE) Navigator: DTWD2 (2 documents)

    Export disorders for DTWD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DTWD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DTWD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions. (PubMed id 1612591)1 Manrow R.E....Berger S.L. (1992)
    9. Isolation and partial sequencing of the human prothymosin alpha gene family. Evidence against export of the gene products. (PubMed id 2708378)1 Eschenfeldt W.H.... Berger S.L. (1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285605 HGNC: 19334 AceView: FLJ33977 Ensembl:ENSG00000169570 euGenes: HUgn285605
    ECgene: DTWD2 H-InvDB: DTWD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DTWD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DTWD2 gene:
    Search GeneIP for patents involving DTWD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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