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DTWD1 Gene

protein-coding   GIFtS: 42
GCID: GC15P049913

DTW Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DTW Domain Containing 11 2
DTW Domain-Containing Protein 12
X 009 Protein2

External Ids:    HGNC: 309261   Entrez Gene: 569862   Ensembl: ENSG000001040477   UniProtKB: Q8N5C73   

Export aliases for DTWD1 gene to outside databases

Previous GC identifers: GC15P047701 GC15P026744


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DTWD1 Gene:
DTWD1 (DTW domain containing 1) is a protein-coding gene. Diseases associated with DTWD1 include atherosclerosis, and malaria.

Gene Wiki entry for DTWD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DTWD1 gene promoter:
         AML1a   NF-kappaB   RORalpha2   c-Rel   NF-kappaB2   Sox9   c-Myb   NF-kappaB1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDTWD1 promoter sequence
   Search Chromatin IP Primers for DTWD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTWD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

DTWD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTWD1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P049913:  view genomic region     (about GC identifiers)

Start:
49,913,177 bp from pter      End:
49,937,333 bp from pter
Size:
24,157 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DTWD1_HUMAN, Q8N5C7 (See protein sequence)
Recommended Name: DTW domain-containing protein 1  
Size: 304 amino acids; 35248 Da
Sequence caution: Sequence=AAF87319.1; Type=Frameshift; Positions=132, 182, 187, 188, 192, 194, 196, 199, 204,
207, 209;
Secondary accessions: Q567Q3 Q8WVG9 Q9NRU6
Alternative splicing: 3 isoforms:  Q8N5C7-1   Q8N5C7-2   Q8N5C7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DTWD1: NX_Q8N5C7

Explore proteomics data for DTWD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DTWD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138427.1  NP_064619.2  

    ENSEMBL proteins: 
     ENSP00000385399   ENSP00000452628   ENSP00000453529   ENSP00000453686   ENSP00000453071  
     ENSP00000453649   ENSP00000452685   ENSP00000251250   ENSP00000329313   ENSP00000398958  

    DTWD1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DTWD1
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    Novus Biologicals DTWD1 Protein
    Novus Biologicals DTWD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DTWD1

    DTWD1 Antibody Products:

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    Abcam antibodies for DTWD1
    Cloud-Clone Corp. Antibodies for DTWD1
    Search ThermoFisher Antibodies for DTWD1
    LSBio Antibodies in human, mouse, rat for DTWD1

    DTWD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DTWD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DTWD1
    Cloud-Clone Corp. CLIAs for DTWD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005636 DTW

    Graphical View of Domain Structure for InterPro Entry Q8N5C7

    ProtoNet protein and cluster: Q8N5C7

    UniProtKB/Swiss-Prot: DTWD1_HUMAN, Q8N5C7
    Domain: Contains 1 DXTW motif
    Similarity: Belongs to the DTW family


    DTWD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DTWD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DTWD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DTWD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DTWD1

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate DTWD1:
    hsa-miR-33a* hsa-miR-146a* hsa-miR-374a* hsa-miR-548p hsa-miR-34b hsa-miR-330-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DTWD1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DTWD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DTWD1 (NM_020234)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTWD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTWD1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTWD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DTWD1
    Interactions:

        Search GeneGlobe Interaction Network for DTWD1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DTWD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DTWD1 gene (2 alternative transcripts): 
    NM_001144955.1  NM_020234.5  

    Unigene Cluster for DTWD1:

    DTW domain containing 1
    Hs.127432  [show with all ESTs]
    Unigene Representative Sequence: NM_020234
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403028 ENST00000557968(uc001zxp.4) ENST00000559223 ENST00000558653
    ENST00000561188 ENST00000557988 ENST00000560735 ENST00000559164 ENST00000560632
    ENST00000559405 ENST00000251250(uc001zxq.3 uc001zxs.3 uc001zxr.3)
    ENST00000329873 ENST00000415425
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate DTWD1:
    hsa-miR-33a* hsa-miR-146a* hsa-miR-374a* hsa-miR-548p hsa-miR-34b hsa-miR-330-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DTWD1
    Predesigned siRNA for gene silencing in human, mouse, rat DTWD1
    Clone
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    OriGene clones in human, mouse for DTWD1 (see all 13)
    OriGene ORF clones in mouse, rat for DTWD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DTWD1 (NM_020234)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTWD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTWD1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DTWD1
    OriGene qSTAR qPCR primer pairs in human, mouse for DTWD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTWD1
      QuantiTect SYBR Green Assays in human, mouse, rat DTWD1
      QuantiFast Probe-based Assays in human, mouse, rat DTWD1

    Additional mRNA sequence: 

    AF168717.1 AK290184.1 BC018028.1 BC032535.2 BC093073.1 

    13 DOTS entries:

    DT.312655  DT.100024550  DT.100776815  DT.121031693  DT.107936  DT.100776816  DT.91682440  DT.91751936 
    DT.100720321  DT.121031688  DT.91687620  DT.121031695  DT.75166325 

    Selected AceView cDNA sequences (see all 145):

    BM767435 CD676854 CR621462 AI799224 BQ719406 AI167629 BM998169 BQ067819 
    BC032535 BX101081 BQ009258 AI141247 AI740849 BU625894 BG779860 BM849804 
    AL598034 AI669416 AW150854 AW769792 AW452163 AA449019 BG113970 BG498717 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DTWD1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                          -     -           -     -     -     -     -                                       
    SP2:                          -     -           -                                                               
    SP3:                          -     -           -     -     -     -     -     -                                 
    SP4:                          -     -           -     -     -     -                                             
    SP5:                          -     -           -     -     -     -     -     -     -                           


    ECgene alternative splicing isoforms for DTWD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DTWD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATCATCAG
    DTWD1 Expression
    About this image

    DTWD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DTWD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127432
        Custom PCR Arrays for DTWD1
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    QuantiFast Probe-based Assays in human, mouse, rat DTWD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTWD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DTWD1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtwd11 , 5 DTW domain containing 11, 5 78.84(n)1
    73.68(a)1
      2 (61.76 cM)5
    691851  NM_026981.21  NP_081257.11 
     1261545415 
    chicken
    (Gallus gallus)
    Aves LOC7703181 DTW domain-containing protein 1-like 71.28(n)
    69.59(a)
      770318  XM_003641815.2  XP_003641863.2 
    lizard
    (Anolis carolinensis)
    Reptilia DTWD16
    DTW domain containing 1
    65(a)
    1 ↔ 1
    GL343506.1(127090-140083)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237652 Xenopus laevis transcribed sequence with weak similarity more 75.69(n)    BU901523.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570511152   -- 76.39(n)    57051115 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG20061 CG2006 49.26(n)
    43.37(a)
      43472  NM_001202381.2  NP_001189310.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y53C12A.101 Y53C12A.10 51.45(n)
    41.54(a)
      13186571  NM_001267293.1  NP_001254222.1 


    ENSEMBL Gene Tree for DTWD1 (if available)
    TreeFam Gene Tree for DTWD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DTWD1 gene

    DTWD1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DTWD1
    PGOHUM00000250261 PGOHUM00000237829


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DTWD1 (see all 462)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs767841111,2
    C,F--49915301(+) ATCCAC/TAGGAA 2 -- int12Minor allele frequency- T:0.02WA NA 238
    rs174025691,2
    C,F,H--49915406(+) TGAGCT/CACTCC 2 -- int110Minor allele frequency- C:0.10NA NS EA WA 800
    rs1180172001,2
    C,F--49915451(+) TCTGAA/GTAACT 2 -- int11Minor allele frequency- G:0.01NA 120
    rs1169323421,2
    C,F--49915532(+) GTTTAG/AGTGAA 2 -- int11Minor allele frequency- A:0.03EA 120
    rs1458136901,2
    --49915567(+) GAGACA/GCCAAC 2 -- int10--------
    rs1931407411,2
    --49915730(+) GCTAGC/TATTAT 2 -- int10--------
    rs745035171,2
    C,F--49915755(+) ATGCGT/CGGCCC 2 -- int14Minor allele frequency- C:0.21WA CSA 124
    rs1488599441,2
    C--49915895(+) GTGATC/TCCTAA 2 -- ut51 int10--------
    rs116301351,2
    H--49915907(+) AGAATC/GTGAGG 2 -- ut51 int1 ese34Minor allele frequency- G:0.00NS EA 420
    rs1844017741,2
    --49915943(+) TCCTGC/TACTTT 2 -- ut51 int10--------

    HapMap Linkage Disequilibrium report for DTWD1 (49913177 - 49937333 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DTWD1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DTWD1
    DNA2.0 Custom Variant and Variant Library Synthesis for DTWD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for DTWD1:    
    About MalaCards
    atherosclerosis    malaria


    DTWD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DTWD1

    Export disorders for DTWD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DTWD1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DTWD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PubMed id 22041458)1, 4 Clark S.L....van den Oord E.J. (Psychol Med 2012)
    2. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    4. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)4 O'Donnell C.J....Demissie S. (BMC Med. Genet. 2007)
    5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56986 HGNC: 30926 AceView: MDS009 Ensembl:ENSG00000104047 euGenes: HUgn56986
    ECgene: DTWD1 H-InvDB: DTWD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DTWD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DTWD1 gene:
    Search GeneIP for patents involving DTWD1

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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