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Aliases for DTWD1 Gene

Aliases for DTWD1 Gene

  • DTW Domain Containing 1 2 3 5
  • DTW Domain-Containing Protein 1 3
  • X 009 Protein 3
  • MDS009 3

External Ids for DTWD1 Gene

Previous GeneCards Identifiers for DTWD1 Gene

  • GC15P047701
  • GC15P049913
  • GC15P026744

Summaries for DTWD1 Gene

GeneCards Summary for DTWD1 Gene

DTWD1 (DTW Domain Containing 1) is a Protein Coding gene.

Gene Wiki entry for DTWD1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTWD1 Gene

Genomics for DTWD1 Gene

Regulatory Elements for DTWD1 Gene

Enhancers for DTWD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F049846 0.8 FANTOM5 Ensembl ENCODE 19.6 +226.8 226797 3.1 TBP CTCF MXI1 JUN MAX RAD21 BRCA1 GATA3 SMC3 FOS DTWD1 FAM227B FGF7 ATP8B4 LOC102724587 RLIMP3
GH15F049831 1 Ensembl ENCODE 18.6 +211.0 211041 1.7 CTCF MAX EP300 RAD21 GATA3 CBX1 SCRT2 SMC3 NFE2 FOS DTWD1 FAM227B LOC102724587 FGF7 RLIMP3
GH15F049844 0.7 ENCODE 17.5 +223.5 223516 0.7 KDM1A MAFK HHEX DTWD1 FAM227B ATP8B4 LOC102724587 RLIMP3
GH15F049462 0.6 Ensembl ENCODE 15.8 -158.4 -158411 0.5 DTWD1 FAM227B LOC105370811 FGF7
GH15F049645 0.5 ENCODE 11.5 +25.1 25124 0.3 GTF2F1 MXI1 MAX RFX5 GATA3 POLR2A GATA2 SMC3 RCOR1 MAFK FAM227B DTWD1 GC15P049652
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DTWD1 on UCSC Golden Path with GeneCards custom track

Promoters for DTWD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000407709 320 3001 CREB3L1 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for DTWD1 Gene

Chromosome:
15
Start:
49,620,980 bp from pter
End:
49,656,232 bp from pter
Size:
35,253 bases
Orientation:
Plus strand

Genomic View for DTWD1 Gene

Genes around DTWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTWD1 Gene

Proteins for DTWD1 Gene

  • Protein details for DTWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5C7-DTWD1_HUMAN
    Recommended name:
    DTW domain-containing protein 1
    Protein Accession:
    Q8N5C7
    Secondary Accessions:
    • Q567Q3
    • Q8WVG9
    • Q9NRU6

    Protein attributes for DTWD1 Gene

    Size:
    304 amino acids
    Molecular mass:
    35248 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF87319.1; Type=Frameshift; Positions=132, 182, 187, 188, 192, 194, 196, 199, 204, 207, 209; Evidence={ECO:0000305};

    Alternative splice isoforms for DTWD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTWD1 Gene

Post-translational modifications for DTWD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DTWD1 Gene

Domains & Families for DTWD1 Gene

Protein Domains for DTWD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DTWD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5C7

UniProtKB/Swiss-Prot:

DTWD1_HUMAN :
  • Contains 1 DXTW motif.
  • Belongs to the DTW family.
Domain:
  • Contains 1 DXTW motif.
Family:
  • Belongs to the DTW family.
genes like me logo Genes that share domains with DTWD1: view

No data available for Gene Families for DTWD1 Gene

Function for DTWD1 Gene

Phenotypes for DTWD1 Gene

GenomeRNAi human phenotypes for DTWD1:
genes like me logo Genes that share phenotypes with DTWD1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DTWD1 Gene

Localization for DTWD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTWD1 Gene COMPARTMENTS Subcellular localization image for DTWD1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DTWD1 Gene

Pathways & Interactions for DTWD1 Gene

SuperPathways for DTWD1 Gene

No Data Available

Interacting Proteins for DTWD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000251250%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q8N5C7-DTWD1_HUMAN ENSP00000251250 for DTWD1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for DTWD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DTWD1 Gene

Transcripts for DTWD1 Gene

Unigene Clusters for DTWD1 Gene

DTW domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTWD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: -
SP8: - - - - - - -

Relevant External Links for DTWD1 Gene

GeneLoc Exon Structure for
DTWD1
ECgene alternative splicing isoforms for
DTWD1

Expression for DTWD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DTWD1 Gene

Protein differential expression in normal tissues from HIPED for DTWD1 Gene

This gene is overexpressed in Ovary (54.1) and Adrenal (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DTWD1 Gene



Protein tissue co-expression partners for DTWD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DTWD1 Gene:

DTWD1

SOURCE GeneReport for Unigene cluster for DTWD1 Gene:

Hs.127432
genes like me logo Genes that share expression patterns with DTWD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DTWD1 Gene

Orthologs for DTWD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTWD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTWD1 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia DTWD1 34 35
  • 93.31 (n)
cow
(Bos Taurus)
Mammalia DTWD1 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtwd1 34
  • 79.39 (n)
mouse
(Mus musculus)
Mammalia Dtwd1 34 16 35
  • 78.84 (n)
oppossum
(Monodelphis domestica)
Mammalia DTWD1 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTWD1 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC770318 34
  • 71.28 (n)
DTWD1 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTWD1 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtwd1 34
  • 68.24 (n)
Str.17345 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23765 34
zebrafish
(Danio rerio)
Actinopterygii dtwd1 34 35
  • 56.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004295 34
  • 51.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2006 34 35
  • 49.26 (n)
worm
(Caenorhabditis elegans)
Secernentea Y53C12A.10 34 35
  • 51.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3444 35
  • 43 (a)
OneToOne
Species where no ortholog for DTWD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTWD1 Gene

ENSEMBL:
Gene Tree for DTWD1 (if available)
TreeFam:
Gene Tree for DTWD1 (if available)

Paralogs for DTWD1 Gene

Pseudogenes.org Pseudogenes for DTWD1 Gene

genes like me logo Genes that share paralogs with DTWD1: view

No data available for Paralogs for DTWD1 Gene

Variants for DTWD1 Gene

Sequence variations from dbSNP and Humsavar for DTWD1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152191 -- 49,653,253(+) gaaga(C/T)ggata intron-variant
rs10220770 -- 49,629,638(+) TTTCA(A/C)CTGAG intron-variant
rs10220846 -- 49,631,162(+) tcccc(A/C)aaccc intron-variant
rs1048348 -- 49,644,041(+) AATTC(C/T)GGTAT intron-variant, utr-variant-3-prime
rs10519234 -- 49,640,947(+) ACTAT(A/G)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTWD1 Gene

Variant ID Type Subtype PubMed ID
nsv569392 CNV loss 21841781

Variation tolerance for DTWD1 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTWD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTWD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTWD1 Gene

Disorders for DTWD1 Gene

Relevant External Links for DTWD1

Genetic Association Database (GAD)
DTWD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTWD1

No disorders were found for DTWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTWD1 Gene

Publications for DTWD1 Gene

  1. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark S.L. … van den Oord E.J. (Psychol Med 2012) 3 46 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PMID: 17903303) O'Donnell C.J. … Demissie S. (BMC Med. Genet. 2007) 46 64

Products for DTWD1 Gene

Sources for DTWD1 Gene

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