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Aliases for DTNB Gene

Aliases for DTNB Gene

  • Dystrobrevin Beta 2 3 5
  • Dystrobrevin, Beta 2 3
  • Beta-Dystrobrevin 3 4
  • DTN-B 3 4

External Ids for DTNB Gene

Previous GeneCards Identifiers for DTNB Gene

  • GC02M025521
  • GC02M025692
  • GC02M025557
  • GC02M025574
  • GC02M025511
  • GC02M025453
  • GC02M025600
  • GC02M025337

Summaries for DTNB Gene

Entrez Gene Summary for DTNB Gene

  • This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]

GeneCards Summary for DTNB Gene

DTNB (Dystrobrevin Beta) is a Protein Coding gene. Among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DRP2.

Gene Wiki entry for DTNB Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTNB Gene

Genomics for DTNB Gene

Regulatory Elements for DTNB Gene

Enhancers for DTNB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DTNB on UCSC Golden Path with GeneCards custom track

Promoters for DTNB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DTNB on UCSC Golden Path with GeneCards custom track

Genomic Location for DTNB Gene

Chromosome:
2
Start:
25,377,198 bp from pter
End:
25,673,647 bp from pter
Size:
296,450 bases
Orientation:
Minus strand

Genomic View for DTNB Gene

Genes around DTNB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTNB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTNB Gene

Proteins for DTNB Gene

  • Protein details for DTNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60941-DTNB_HUMAN
    Recommended name:
    Dystrobrevin beta
    Protein Accession:
    O60941
    Secondary Accessions:
    • B7Z733
    • F5GZG4
    • G5E9F6
    • O43782
    • O60881
    • O75538
    • Q86VR4
    • Q96AW0
    • Q9UE14
    • Q9UE15
    • Q9UE16

    Protein attributes for DTNB Gene

    Size:
    627 amino acids
    Molecular mass:
    71356 Da
    Quaternary structure:
    • Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2. Binds dystrobrevin binding protein 1 (By similarity).

    Alternative splice isoforms for DTNB Gene

neXtProt entry for DTNB Gene

Proteomics data for DTNB Gene at MOPED

Post-translational modifications for DTNB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DTNB Gene

Domains & Families for DTNB Gene

Gene Families for DTNB Gene

Protein Domains for DTNB Gene

Graphical View of Domain Structure for InterPro Entry

O60941

UniProtKB/Swiss-Prot:

DTNB_HUMAN :
  • The coiled coil domain may mediate the interaction with dystrophin.
  • Belongs to the dystrophin family. Dystrobrevin subfamily.
  • Contains 1 ZZ-type zinc finger.
Domain:
  • The coiled coil domain may mediate the interaction with dystrophin.
Family:
  • Belongs to the dystrophin family. Dystrobrevin subfamily.
Similarity:
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with DTNB: view

Function for DTNB Gene

Molecular function for DTNB Gene

GENATLAS Biochemistry:
dystrobrevin beta,71kDa,dystrophin related,copurifying with DP71 and DP140 dystrophins,significantly homologous to DBVA,expressed in brain and other tissues but not in muscle
genes like me logo Genes that share phenotypes with DTNB: view

Animal Models for DTNB Gene

MGI Knock Outs for DTNB:

Animal Model Products

  • Taconic Biosciences Mouse Models for DTNB

miRNA for DTNB Gene

miRTarBase miRNAs that target DTNB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DTNB Gene

Localization for DTNB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTNB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTNB Gene COMPARTMENTS Subcellular localization image for DTNB gene
Compartment Confidence
golgi apparatus 2
cytosol 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DTNB Gene

Pathways & Interactions for DTNB Gene

genes like me logo Genes that share pathways with DTNB: view

Pathways by source for DTNB Gene

Gene Ontology (GO) - Biological Process for DTNB Gene

None

No data available for SIGNOR curated interactions for DTNB Gene

Drugs & Compounds for DTNB Gene

(1) Additional Compounds for DTNB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DTNB: view

Transcripts for DTNB Gene

Unigene Clusters for DTNB Gene

Dystrobrevin, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTNB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: -
SP5: -
SP6: -
SP7: - -
SP8:
SP9:
SP10:

ExUns: 19b ^ 20 ^ 21a · 21b ^ 22
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:

Relevant External Links for DTNB Gene

GeneLoc Exon Structure for
DTNB
ECgene alternative splicing isoforms for
DTNB

Expression for DTNB Gene

mRNA expression in normal human tissues for DTNB Gene

mRNA differential expression in normal tissues according to GTEx for DTNB Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.0).

Protein differential expression in normal tissues from HIPED for DTNB Gene

This gene is overexpressed in Heart (20.1), Colon (11.6), Salivary gland (10.2), and Fetal gut (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DTNB Gene



SOURCE GeneReport for Unigene cluster for DTNB Gene Hs.307720

mRNA Expression by UniProt/SwissProt for DTNB Gene

O60941-DTNB_HUMAN
Tissue specificity: Highly expressed in brain, kidney and pancreas.
genes like me logo Genes that share expression patterns with DTNB: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for DTNB Gene

Orthologs for DTNB Gene

This gene was present in the common ancestor of animals.

Orthologs for DTNB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DTNB 35
  • 94.42 (n)
  • 97.93 (a)
DTNB 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DTNB 35
  • 95.11 (n)
  • 98.09 (a)
DTNB 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtnb 35
  • 91.57 (n)
  • 95.84 (a)
Dtnb 16
Dtnb 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DTNB 35
  • 99.84 (n)
  • 99.84 (a)
DTNB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtnb 35
  • 91.35 (n)
  • 96.17 (a)
oppossum
(Monodelphis domestica)
Mammalia DTNB 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTNB 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTNB 35
  • 82.26 (n)
  • 92.28 (a)
lizard
(Anolis carolinensis)
Reptilia DTNB 36
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dtnb 35
dtnbb 35
  • 75.13 (n)
  • 83.13 (a)
dtnbb 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dyb 35
  • 55.82 (n)
  • 53.06 (a)
Dyb 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dyb-1 37
  • 42 (a)
dyb-1 35
  • 52.79 (n)
  • 50.38 (a)
dyb-1 36
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToMany
Species with no ortholog for DTNB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DTNB Gene

ENSEMBL:
Gene Tree for DTNB (if available)
TreeFam:
Gene Tree for DTNB (if available)

Paralogs for DTNB Gene

Paralogs for DTNB Gene

genes like me logo Genes that share paralogs with DTNB: view

Variants for DTNB Gene

Sequence variations from dbSNP and Humsavar for DTNB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17854576 - 25,628,243(+) TAGAA(G/T)GAAGG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs17854577 - 25,628,186(+) CAGCA(A/G)TCATA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs476731 -- 25,537,044(+) ccCCA(C/T)ACTGC intron-variant
rs478237 -- 25,553,016(+) CCACC(A/G)CGCCC intron-variant
rs483490 -- 25,533,395(-) TTTCG(C/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTNB Gene

Variant ID Type Subtype PubMed ID
esv33372 CNV Loss 17666407
esv2719823 CNV Deletion 23290073
esv4217 CNV Deletion 18987735
nsv512768 CNV Insertion 21212237
esv33756 CNV Gain 17666407
esv33316 CNV Loss 17666407
esv2675591 CNV Deletion 23128226
esv2719824 CNV Deletion 23290073
esv2671046 CNV Deletion 23128226
nsv819351 CNV Gain 19587683
nsv873743 CNV Loss 21882294
esv25482 CNV Loss 19812545

Variation tolerance for DTNB Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTNB Gene

HapMap Linkage Disequilibrium report
DTNB
Human Gene Mutation Database (HGMD)
DTNB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTNB Gene

Disorders for DTNB Gene

Relevant External Links for DTNB

Genetic Association Database (GAD)
DTNB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTNB

No disorders were found for DTNB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTNB Gene

Publications for DTNB Gene

  1. Beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations. (PMID: 9395493) Peters M.F. … Froehner S.C. (J. Biol. Chem. 1997) 3 4 23 67
  2. beta-dystrobrevin, a member of the dystrophin-related protein family. (PMID: 9419360) Blake D.J. … Davies K.E. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 23
  3. Identification and characterization of a novel member of the dystrobrevin gene family. (PMID: 9540997) Puca A.A. … Franco B. (FEBS Lett. 1998) 3 23
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for DTNB Gene

Sources for DTNB Gene

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