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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DTL Gene

protein-coding   GIFtS: 53
GCID: GC01P212208

Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)

(Previous name: denticleless homolog (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)1 2     L2DTL2 3
CDT22 3 5     DDB1- And CUL4-Associated Factor 22 3
DCAF22 3 5     Denticleless Homolog (Drosophila)1
RAMP2 3 5     Denticleless Homolog2
DDB1 And CUL4 Associated Factor 21 2     Denticleless Protein Homolog2
RA Regulated Nuclear Matrix Associated Protein1 2     RA-Regulated Nuclear Matrix-Associated Protein2
Lethal(2) Denticleless Protein Homolog2 3     CDW13
Retinoic Acid-Regulated Nuclear Matrix-Associated Protein2 3     

External Ids:    HGNC: 302881   Entrez Gene: 515142   Ensembl: ENSG000001434767   OMIM: 6106175   UniProtKB: Q9NZJ03   

Export aliases for DTL gene to outside databases

Previous GC identifers: GC01P208598 GC01P210275 GC01P182885


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DTL Gene: 
DTL (denticleless E3 ubiquitin protein ligase homolog (Drosophila)) is a protein-coding gene. Diseases associated with DTL include osteosarcoma, and esophageal squamous cell carcinoma. GO annotations related to this gene include ubiquitin-protein ligase activity and protein binding.

UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for
cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named
CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1
degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication.
CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication
licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact
with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex,
leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164'
monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis

Gene Wiki entry for DTL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DTL gene promoter:
         STAT5B   p53   Bach2   C/EBPalpha   GATA-1   GATA-2   AREB6   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDTL promoter sequence
   Search SABiosciences Chromatin IP Primers for DTL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32

DTL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P212208:  view genomic region     (about GC identifiers)

Start:
212,208,919 bp from pter      End:
212,280,742 bp from pter
Size:
71,824 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0 (See protein sequence)
Recommended Name: Denticleless protein homolog  
Size: 730 amino acids; 79468 Da
Subunit: Component of the DCX(DTL) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1,
DTL/CDT2 and RBX1. Interacts with CDKN1A and CDT1
Subcellular location: Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm,
cytoskeleton, microtubule organizing center, centrosome. Note=Nuclear matrix-associated protein. Translocates
from the interphase nucleus to the metaphase cytoplasm during mitosis
Developmental stage: Expressed in all fetal tissues examined, included brain, lung, liver, and kidney
Sequence caution: Sequence=BAA91552.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91586.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K8H8 D3DT98 Q5VT77 Q96SN0 Q9NW03 Q9NW34 Q9NWM5
Alternative splicing: 2 isoforms:  Q9NZJ0-1   Q9NZJ0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DTL: NX_Q9NZJ0

Explore proteomics data for DTL at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZJ0

  • DTL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DTL Protein Expression
    REFSEQ proteins: NP_057532.2  
    ENSEMBL proteins: 
     ENSP00000355958   ENSP00000443870  

    Human Recombinant Protein Products for DTL: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA17106265
    GO:0031464Cul4A-RING ubiquitin ligase complex IDA17085480

    DTL for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZJ0

    ProtoNet protein and cluster: Q9NZJ0

    UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
    Similarity: Belongs to the WD repeat cdt2 family
    Similarity: Contains 7 WD repeats


    DTL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DTL_HUMAN, Q9NZJ0
    Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for
    cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named
    CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1
    degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication.
    CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication
    licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact
    with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex,
    leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164'
    monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA18794347
    GO:0005515protein binding IPI17041588
         
    DTL for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for DTL:
     Bright nuclei  Decreased cell number, increas  Decreased viability of wild-ty  G2 arrest 
     Increased ID2::GFP protein exp  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dtl):
     mortality/aging 

    DTL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dtltm1Hch for DTL

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DTL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DTL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DTL 
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    miRTarBase miRNAs that target DTL:
    hsa-mir-192 (MIRT004848)

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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate DTL (see all 29):
    hsa-miR-607 hsa-miR-3660 hsa-miR-1271 hsa-miR-200a hsa-miR-628-3p hsa-miR-507 hsa-miR-3680 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidDTL 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DTL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for DTL (Q9NZJ01, 3 ENSP000003559584) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDB1Q165311, 3, ENSP000003017644EBI-1176075,EBI-350322 I2D: score=3 STRING: ENSP00000301764
    WDR5P619643, ENSP000003514464I2D: score=2 STRING: ENSP00000351446
    GRWD1Q9BQ673, ENSP000002532374I2D: score=1 STRING: ENSP00000253237
    KAT2AQ928303, ENSP000002259164I2D: score=1 STRING: ENSP00000225916
    CDKN1AP389363, ENSP000002447414I2D: score=1 STRING: ENSP00000244741
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination TAS17085480
    GO:0006260DNA replication IEA--
    GO:0006511ubiquitin-dependent protein catabolic process TAS17085480
    GO:0006513protein monoubiquitination IDA--
    GO:0006974response to DNA damage stimulus IDA--

    DTL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DTL

    Search CenterWatch for drugs/clinical trials and news about DTL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DTL gene: 
    NM_016448.2  

    Unigene Cluster for DTL:

    Denticleless E3 ubiquitin protein ligase homolog (Drosophila)
    Hs.656473  [show with all ESTs]
    Unigene Representative Sequence: NM_016448
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366991(uc009xdc.3 uc010ptb.2 uc001hiz.4) ENST00000475419
    ENST00000489149 ENST00000463791 ENST00000496442 ENST00000542077
    miRNA
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate DTL (see all 29):
    hsa-miR-607 hsa-miR-3660 hsa-miR-1271 hsa-miR-200a hsa-miR-628-3p hsa-miR-507 hsa-miR-3680 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidDTL 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF195765.1 AF345896.1 AK000742.1 AK027651.1 AK292343.1 AK299649.1 AK303346.1 BC033297.1 
    BC033540.1 DQ641253.1 

    9 DOTS entries:

    DT.99931047  DT.405249  DT.100777368  DT.100777372  DT.91751062  DT.100777366  DT.121378502  DT.75192561 
    DT.91743762 

    24/147 AceView cDNA sequences (see all 147):

    NM_016448 AA505890 AK000742 BM800170 BG288414 AA252326 BX416133 AF195765 
    BQ431493 BI257561 AL553783 AA913841 BU521670 AW339528 AA252192 AI969579 
    BF512555 AW069881 BC033297 AA581038 BF508267 AW440579 AA846697 AA730175 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DTL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b
    SP1:              -                                                                       -                                 
    SP2:              -     -                                         -                       -                                 
    SP3:                                                                                                                        
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for DTL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DTL expression in normal human tissues (normalized intensities)      DTL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGACTTTG
    DTL Expression
    About this image


    DTL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             placenta ; decidual cells   
     
     Epithelium (Reproductive System)    fully expand to see all 2 entries
             cervix, uterine ; squamous epithelial cells   
     
     Smooth Muscle (Muscoskeletal System)
             smooth muscle ; smooth muscle cells   

    See DTL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DTL

    SOURCE GeneReport for Unigene cluster: Hs.656473

    UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
    Tissue specificity: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all
    hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the
    spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the
    expression in NT2 cell

        SABiosciences Expression via Pathway-Focused PCR Array including DTL: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DTL gene from 9/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtl1 , 5 denticleless homolog (Drosophila)1, 5 87.97(n)1
    89.57(a)1
      1 (96.44 cM)5
    768431  NM_029766.21  NP_084042.11 
     1915373655 
    chicken
    (Gallus gallus)
    Aves DTL1 denticleless homolog (Drosophila) 65.65(n)
    64.15(a)
      421373  NM_001031048.1  NP_001026219.1 
    lizard
    (Anolis carolinensis)
    Reptilia DTL6
    denticleless E3 ubiquitin protein ligase homolog (...
    57(a)
    1 ↔ 1
    1(238332217-238360696)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC755742 hypothetical protein MGC75574 76.26(n)    BC064851.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dtl2 denticleless homolog (Drosophila) 75.71(n)   192314  BC045316.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)dtl6
    lethal-(2)-denticleless
    26(a)
    1 ↔ 1
    2R(19590002-19592926)
    worm
    (Caenorhabditis elegans)
    Secernentea cdt-26
    Protein CDT-2
    21(a)
    1 ↔ 1
    V(14987551-14991024)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G276401 protein denticleless 46.94(n)
    36.24(a)
      822386  NM_113680.1  NP_566822.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06991001 hypothetical protein 42.78(n)
    33.69(a)
      4333813  NM_001057520.1  NP_001050985.1 


    ENSEMBL Gene Tree for DTL (if available)
    TreeFam Gene Tree for DTL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DTL gene
    1 SIMAP similar gene for DTL using alignment to 2 protein entries:     DTL_HUMAN (see all proteins):
    GNB5

    DTL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1364 SNPs in DTL are shown (see all 1364)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487395201,2
    --212211100(+) ATAGT-/GGCGG 
     GGGGGGG
    GGTGG
    1 -- cds10--------
    rs15789911,2
    C,F,A--212211103(+) agtggC/Tggtgg 1 -- int19Minor allele frequency- T:0.33NA WA CSA 15
    rs15789921,2
    C,F,A,H--212211174(+) cccagG/Ttcaaa 1 -- int121Minor allele frequency- C:0.09NS EA NA WA CSA 996
    rs1812154261,2
    --212211176(+) CAGGTC/GAAAAA 1 -- int10--------
    rs15789931,2
    C,F,A,H--212211284(+) acaatT/Gatttg 1 -- int122Minor allele frequency- G:0.47NS EA NA WA CSA 2243
    rs1149773691,2
    C,F--212211418(+) GCACTC/GACACA 1 -- int12Minor allele frequency- G:0.04WA NA 238
    rs757350921,2
    C,F--212211459(+) CACCAG/ATGAAC 1 -- int13Minor allele frequency- A:0.14WA CSA 122
    rs618285391,2
    C,F--212211476(+) TACACA/GTCTTT 1 -- int16Minor allele frequency- G:0.29NA CSA WA EA 364
    rs1853600371,2
    --212211483(+) CTTTGA/GCATGT 1 -- int10--------
    rs1480364771,2
    C--212211523(+) CCCTAC/TGAACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DTL (212208919 - 212280742 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DTL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4432CNV Insertion18451855
    nsv506979CNV Insertion20534489

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for DTL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610617    OMIM disorders: --

    10 diseases for DTL:    About MalaCards
    osteosarcoma    esophageal squamous cell carcinoma    colon cancer    gastric cancer
    sarcoma    hepatocellular carcinoma    esophagitis    squamous cell carcinoma
    breast cancer    neuronitis


    DTL for disorders           About GeneDecksing

    Genetic Association Database (GAD): DTL
    Human Genome Epidemiology (HuGE) Navigator: DTL (1 document)

    Export disorders for DTL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DTL gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with DTL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation. (PubMed id 11278750)1, 2, 3, 9 Cheung W.M.... Ip N.Y. (2001)
    2. L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. (PubMed id 16861906)1, 2, 9 Higa L.A.... Zhang H. (2006)
    3. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PubMed id 18649358)1, 4 Ng D....Taylor P.R. (2008)
    4. CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. (PubMed id 18703516)1, 2 Nishitani H....Tsurimoto T. (2008)
    5. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. (PubMed id 18794347)1, 2 Abbas T....Dutta A. (2008)
    6. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (2006)
    7. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. (PubMed id 17085480)1, 2 Sansam C.L....Lees J.A. (2006)
    8. Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. (PubMed id 17106265)1, 2 Pan H.W....Hsu H.C. (2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1, 2 Higa L.A.... Zhang H. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51514 HGNC: 30288 AceView: RAMP Ensembl:ENSG00000143476 euGenes: HUgn51514
    ECgene: DTL H-InvDB: DTL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DTL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DTL gene:
    Search GeneIP for patents involving DTL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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