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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DTL Gene

protein-coding   GIFtS: 51
GCID: GC01P212208

denticleless E3 ubiquitin protein ligase homolog (Drosophila)

(Previous name: denticleless homolog (Drosophila) )
 Explore 7 diseases affiliated with
DTL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DTL    

Aliases
for DTL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)1 2     Denticleless Homolog (Drosophila)1
DCAF21 2 3 5     DDB1 And CUL4 Associated Factor 22
RAMP1 2 3 5     Denticleless Homolog2
L2DTL1 2 3     Denticleless Protein Homolog2
CDT22 3 5     RA Regulated Nuclear Matrix Associated Protein2
Lethal(2) Denticleless Protein Homolog2 3     RA-Regulated Nuclear Matrix-Associated Protein2
Retinoic Acid-Regulated Nuclear Matrix-Associated Protein2 3     CDW13
DDB1- And CUL4-Associated Factor 22 3     

External Ids:    HGNC: 302881   Entrez Gene: 515142   Ensembl: ENSG000001434767   OMIM: 6106175   UniProtKB: Q9NZJ03   

Export aliases for DTL gene to outside databases

Previous GC identifers: GC01P208598 GC01P210275 GC01P182885


Summaries
for DTL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell
cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex,
mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response
to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation
during S phase or following UV irradiation is essential to control replication licensing. Most substrates require
their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those
containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged
proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being
involved in PCNA-dependent translesion DNA synthesis

Gene Wiki entry for DTL


Genomic Views
for DTL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DTL gene promoter:
         STAT5B   p53   Bach2   C/EBPalpha   GATA-1   GATA-2   AREB6   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DTL promoter sequence
   Search SABiosciences Chromatin IP Primers for DTL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32

DTL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P212208:  view genomic region     (about GC identifiers)

Start:
 212,208,919 bp from pter      End:
 212,280,742 bp from pter
Size:
 71,824 bases      Orientation:
 plus strand

Proteins
for DTL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0 (See protein sequence)
Recommended Name: Denticleless protein homolog  
Size: 730 amino acids; 79468 Da
Subunit: Component of the DCX(DTL) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1,
DTL/CDT2 and RBX1. Interacts with CDKN1A and CDT1
Subcellular location: Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm,
cytoskeleton, centrosome. Note=Nuclear matrix-associated protein. Translocates from the interphase nucleus to the
metaphase cytoplasm during mitosis
Developmental stage: Expressed in all fetal tissues examined, included brain, lung, liver, and kidney
Sequence caution: Sequence=BAA91552.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91586.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K8H8 D3DT98 Q5VT77 Q96SN0 Q9NW03 Q9NW34 Q9NWM5
Alternative splicing: 2 isoforms:  Q9NZJ0-1   Q9NZJ0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DTL: NX_Q9NZJ0

Post-translational modifications:

  • Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZJ0

    • DTL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057532.2  
    ENSEMBL proteins: 
     ENSP00000355958   ENSP00000443870  

    Human Recombinant Protein Products: 
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    Novus Biologicals DTL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DTL

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA17106265
    GO:0031464Cul4A-RING ubiquitin ligase complex IDA18794347
    GO:0031465Cul4B-RING ubiquitin ligase complex IDA18794347


    DTL for ontologies           About GeneDecksing



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    Uscn Antibodies for DTL
    ThermoFisher Antibodies for DTL

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    Uscn ELISAs and CLIAs for DTL

    Protein Domains /
    Families
    for DTL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DTL for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZJ0

    ProtoNet protein and cluster: Q9NZJ0

    UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
    Similarity: Belongs to the WD repeat cdt2 family
    Similarity: Contains 7 WD repeats


    Function
    for DTL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
    Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell
    cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex,
    mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response
    to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation
    during S phase or following UV irradiation is essential to control replication licensing. Most substrates require
    their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those
    containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged
    proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being
    involved in PCNA-dependent translesion DNA synthesis

    miRNA
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    hsa-mir-192 (MIRT004848)

    OriGene 3'-UTR Clone: DTL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DTL
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate DTL (see all 29):
    hsa-miR-607 hsa-miR-3660 hsa-miR-1271 hsa-miR-200a hsa-miR-628-3p hsa-miR-507 hsa-miR-3680 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmid: DTL 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DTL (see all 4)
    OriGene shRNA RFP: DTL
    OriGene siRNA: DTL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTL

    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTL

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI17041588


    DTL for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for DTL:
     Bright nuclei  Decreased cell number, increas  Decreased viability of wild-ty  G2 arrest 
     Increased ID2::GFP protein exp  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Dtltm1Hch for DTL
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Dtl):
     mortality/aging 

    DTL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DTL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DTL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for DTL (Q9NZJ01, 3 ENSP000003559584) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDB1Q165311, 3, ENSP000003017644EBI-2559087,EBI-350322 I2D: score=3 STRING: ENSP00000301764
    WDR5P619643, ENSP000003514464I2D: score=2 STRING: ENSP00000351446
    GRWD1Q9BQ673, ENSP000002532374I2D: score=1 STRING: ENSP00000253237
    KAT2AQ928303, ENSP000002259164I2D: score=1 STRING: ENSP00000225916
    CDKN1AP389363, ENSP000002447414I2D: score=1 STRING: ENSP00000244741
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination TAS17085480
    GO:0006260DNA replication IEA--
    GO:0006511ubiquitin-dependent protein catabolic process TAS17085480
    GO:0006513protein monoubiquitination IDA--
    GO:0006974response to DNA damage stimulus IDA--


    DTL for ontologies           About GeneDecksing



    Drugs & Compounds
    for DTL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DTL
    Search CenterWatch for drugs/clinical trials and news about DTL 

    Transcripts
    for DTL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DTL gene: 
    NM_016448.2  

    Unigene Cluster for DTL:

    Denticleless E3 ubiquitin protein ligase homolog (Drosophila)
    Hs.656473  [show with all ESTs]
    Unigene Representative Sequence: NM_016448
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366991(uc009xdc.3 uc010ptb.2 uc001hiz.4) ENST00000475419
    ENST00000489149 ENST00000463791 ENST00000496442 ENST00000542077

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DTL
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate DTL (see all 29):
    hsa-miR-607 hsa-miR-3660 hsa-miR-1271 hsa-miR-200a hsa-miR-628-3p hsa-miR-507 hsa-miR-3680 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmid: DTL 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DTL (see all 4)
    OriGene shRNA RFP: DTL
    OriGene siRNA: DTL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTL
    Clone
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    GenScript: all cDNA clones in your preferred vector: DTL (NM_016448)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTL 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DTL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTL

    Additional cDNA sequence: 

    AF195765.1 AF345896.1 AK000742.1 AK027651.1 AK292343.1 AK299649.1 AK303346.1 BC033297.1 
    BC033540.1 DQ641253.1 

    9 DOTS entries:

    DT.99931047  DT.405249  DT.100777368  DT.100777372  DT.91751062  DT.100777366  DT.121378502  DT.75192561 
    DT.91743762 

    24/147 AceView cDNA sequences (see all 147):

    AF195765 AL553783 AW069881 BQ431493 BU521670 BF508267 BF512555 AA846697 
    BM800170 AA913841 BX416133 AA252192 AW440579 BI257561 BC033297 AA581038 
    AK000742 AA505890 AI969579 AA730175 BG288414 NM_016448 AA252326 AW339528 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DTL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b
    SP1:              -                                                                       -                                 
    SP2:              -     -                                         -                       -                                 
    SP3:                                                                                                                        
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for DTL

    Expression
    for DTL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DTL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGACTTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DTL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)

    See DTL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DTL

    SOURCE GeneReport for Unigene cluster: Hs.656473

    UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
    Tissue specificity: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all
    hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen
    and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression
    in NT2 cell

        SABiosciences Expression via Pathway-Focused PCR Array including DTL: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTL

    Orthologs
    for DTL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DTL gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dtl1 , 5 denticleless homolog (Drosophila)1, 5 87.97(n)1
    89.57(a)1    		   1 (96.44 cM)5
    768431  NM_029766.21  NP_084042.11 
     1915373655 
    chicken
    (Gallus gallus)    		 Aves DTL1 denticleless homolog (Drosophila) 65.65(n)
    64.15(a)    		   421373  NM_001031048.1  NP_001026219.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DTL6
    		 --
    		 57(a)
    		 1 ↔ 1
    		 1(238332848-238360338)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia MGC755742 hypothetical protein MGC75574 76.26(n)    BC064851.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dtl2 denticleless homolog (Drosophila) 75.71(n)   192314  BC045316.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta l(2)dtl6
    		 lethal-(2)-denticleless
    		 27(a)
    		 1 ↔ 1
    		 2R(19590002-19592926)
    worm
    (Caenorhabditis elegans)    		 Secernentea cdt-26
    		 --
    		 19(a)
    		 1 ↔ 1
    		 V(14987534-14991007)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G276401 protein denticleless 46.94(n)
    36.24(a)    		   822386  NM_113680.1  NP_566822.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g06991001 hypothetical protein 42.78(n)
    33.69(a)    		   4333813  NM_001057520.1  NP_001050985.1 


    ENSEMBL Gene Tree for DTL (if available)
    TreeFam Gene Tree for DTL (if available) 

    Paralogs
    for DTL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DTL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1242 NCBI SNPs in DTL are shown (see all 1242)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1487395201,2
    		--212211100(+) ATAGT-/GGCGG 
     GGGGGGG    GGTGG     		1 -- int10--------
    rs15789911,2
    		C,F,A,,--212211103(+) AGTGGC/TGGTGG 1 -- int19Minor allele frequency- T:0.33NA WA CSA 15
    rs15789921,2
    		C,F,A,H,--212211174(+) CCCAGG/TTCAAA 1 -- int121Minor allele frequency- C:0.09NS EA NA WA CSA 996
    rs1812154261,2
    		--212211176(+) CAGGTC/GAAAAA 1 -- int10--------
    rs15789931,2
    		C,F,A,H,--212211284(+) ACAATT/GATTTG 1 -- int122Minor allele frequency- G:0.47NS EA NA WA CSA 2243
    rs1149773691,2
    		F,--212211418(+) GCACTC/GACACA 1 -- int12Minor allele frequency- G:0.04WA NA 238
    rs757350921,2
    		C,F,--212211459(+) CACCAG/ATGAAC 1 -- int13Minor allele frequency- A:0.14WA CSA 122
    rs618285391,2
    		C,F,--212211476(+) TACACA/GTCTTT 1 -- int16Minor allele frequency- G:0.29NA CSA WA EA 364
    rs1853600371,2
    		--212211483(+) CTTTGA/GCATGT 1 -- int10--------
    rs1480364771,2
    		--212211523(+) CCCTAC/TGAACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DTL (212208919 - 212280742 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DTL: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DTL
    DNA2.0 Custom Variant and Variant Library Synthesis for DTL

    Disorders / Diseases
    for DTL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DTL for disorders           About GeneDecksing

    OMIM gene information: 610617    OMIM disorders: --

    7 diseases for DTL:    About MalaCards
    hepatocellular carcinoma    colon cancer    gastric cancer    osteosarcoma
    carcinoma    breast cancer    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: DTL (1 document)

    Export disorders for DTL gene to outside databases

    Publications
    for DTL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DTL gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with DTL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation. (PubMed id 11278750)1, 2, 3, 9 Cheung W.M.... Ip N.Y. (2001)
    2. L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. (PubMed id 16861906)1, 2, 9 Higa L.A.... Zhang H. (2006)
    3. CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. (PubMed id 18703516)1, 2 Nishitani H....Tsurimoto T. (2008)
    4. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. (PubMed id 18794347)1, 2 Abbas T....Dutta A. (2008)
    5. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (2006)
    6. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. (PubMed id 17085480)1, 2 Sansam C.L....Lees J.A. (2006)
    7. Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. (PubMed id 17106265)1, 2 Pan H.W....Hsu H.C. (2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    9. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1, 2 Higa L.A.... Zhang H. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    External Searches for DTL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DTL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51514 HGNC: 30288 AceView: RAMP Ensembl:ENSG00000143476 euGenes: HUgn51514
    ECgene: DTL H-InvDB: DTL

    Other Databases showing DTL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DTL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DTL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DTL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DTL gene:
    Search GeneIP for patents involving DTL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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