Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DTL Gene

protein-coding   GIFtS: 53
GCID: GC01P212208

Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)

(Previous name: denticleless homolog (Drosophila))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)1 2     Retinoic Acid-Regulated Nuclear Matrix-Associated Protein2 3
CDT22 3 5     L2DTL2 3
DCAF22 3 5     DDB1- And CUL4-Associated Factor 22 3
RAMP2 3 5     Denticleless Homolog (Drosophila)1
DDB1 And CUL4 Associated Factor 21 2     Denticleless Protein Homolog2
RA Regulated Nuclear Matrix Associated Protein1 2     RA-Regulated Nuclear Matrix-Associated Protein2
Lethal(2) Denticleless Protein Homolog2 3     CDW13

External Ids:    HGNC: 302881   Entrez Gene: 515142   Ensembl: ENSG000001434767   OMIM: 6106175   UniProtKB: Q9NZJ03   

Export aliases for DTL gene to outside databases

Previous GC identifers: GC01P208598 GC01P210275 GC01P182885


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DTL Gene:
DTL (denticleless E3 ubiquitin protein ligase homolog (Drosophila)) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for
cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named
CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and
SETD8. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA
replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control
replication licensing. SETD8 degradation is also important for a proper regulation of mechanisms such as TGF-beta
signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with
PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the
'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged
proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being
involved in PCNA-dependent translesion DNA synthesis

Gene Wiki entry for DTL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DTL gene promoter:
         STAT5B   p53   Bach2   C/EBPalpha   GATA-1   GATA-2   AREB6   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDTL promoter sequence
   Search Chromatin IP Primers for DTL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32

DTL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P212208:  view genomic region     (about GC identifiers)

Start:
212,208,919 bp from pter      End:
212,280,742 bp from pter
Size:
71,824 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0 (See protein sequence)
Recommended Name: Denticleless protein homolog  
Size: 730 amino acids; 79468 Da
Subunit: Component of the DCX(DTL) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1,
DTL/CDT2 and RBX1. Interacts with CDKN1A and CDT1. Interacts with FBXO11; SCF(FBXWO11) controls DTL stability but
DCX(DTL) does not control FBXO11 stability
Developmental stage: Expressed in all fetal tissues examined, included brain, lung, liver, and kidney. Protein
levels peak at G1 and decrease through S-phase
Sequence caution: Sequence=BAA91552.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91586.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K8H8 D3DT98 Q5VT77 Q96SN0 Q9NW03 Q9NW34 Q9NWM5
Alternative splicing: 2 isoforms:  Q9NZJ0-1   Q9NZJ0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DTL: NX_Q9NZJ0

Explore proteomics data for DTL at MOPED

Post-translational modifications: 

  • Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C). Autoubiquitinated through
    'Lys-48'-polyubiquitin chains in a PCNA-independent reaction, allowing proteasomal turnover. Polyubiquitinated by
    SCF(FBXO11) when not phosphorylated, leading to its degradation. A tight regulation of the polyubiquitination by
    SCF(FBXO11) is involved in the control of different processes such as TGF-beta signaling, cell cycle progression
    and exit1
  • Phosphorylated at Thr-464 by CDK1/Cyclin-B and CDK2/Cyclin-A but not by CDK2/Cyclin-E, MAPK1 or PLK1.
    Phosphorylation at Thr-464 inhibits the interaction with FBXO11 and decreases upon cell cycle exit induced by
    TGF-beta or serum starvation1
  • Ubiquitination2 at Lys128, Lys137, Lys260, Lys386, Lys397, Lys432, Lys437
  • Modification sites at PhosphoSitePlus

  • See DTL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273158.1  NP_001273159.1  NP_057532.3  

    ENSEMBL proteins: 
     ENSP00000355958   ENSP00000443870  

    DTL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DTL
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DTL
    GenScript Custom Purified and Recombinant Proteins Services for DTL
    Novus Biologicals DTL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DTL 

     
    antibodies-online proteins for DTL 

     
    antibodies-online peptides for DTL

    DTL Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DTL
    Novus Biologicals DTL Antibodies
    Abcam antibodies for DTL
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for DTL
    antibodies-online antibodies for DTL (34 products) 

    DTL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DTL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DTL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DTL 
    antibodies-online kits for DTL (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZJ0

    ProtoNet protein and cluster: Q9NZJ0

    UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
    Similarity: Belongs to the WD repeat cdt2 family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with DTL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DTL_HUMAN, Q9NZJ0
    Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for
    cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named
    CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and
    SETD8. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA
    replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control
    replication licensing. SETD8 degradation is also important for a proper regulation of mechanisms such as TGF-beta
    signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with
    PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the
    'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged
    proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being
    involved in PCNA-dependent translesion DNA synthesis
    Induction: Induced by TGF-beta, the up-regulation is immediate and transient

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA18794347
    GO:0005515protein binding IPI17041588
         
    Find genes that share ontologies with DTL           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for DTL:
     Bright nuclei  Decreased cell number, increas  Decreased viability of wild-ty  G2 arrest 
     Increased ID2::GFP protein exp  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dtl):
     mortality/aging 

    Find genes that share phenotypes with DTL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dtltm1Hch for DTL

       genOway: Develop your customized and physiologically relevant rodent model for DTL

    miRNA
    Products:
        
    miRTarBase miRNAs that target DTL:
    hsa-mir-26b-5p (MIRT030300), hsa-mir-215-5p (MIRT024273), hsa-mir-30a-5p (MIRT006563), hsa-mir-92a-3p (MIRT049694), hsa-mir-24-3p (MIRT030601), hsa-mir-192-5p (MIRT004848)

    Block miRNA regulation of human, mouse, rat DTL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DTL (see all 29):
    hsa-miR-607 hsa-miR-3660 hsa-miR-1271 hsa-miR-200a hsa-miR-628-3p hsa-miR-507 hsa-miR-3680 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidDTL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DTL
    Predesigned siRNA for gene silencing in human, mouse, rat DTL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DTL

    Clone
    Products:
         
    OriGene clones in human, mouse for DTL (see all 6)
    OriGene ORF clones in mouse, rat for DTL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DTL (NM_016448)
    Sino Biological Human cDNA Clone for DTL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTL

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DTL
    Browse ESI BIO Cell Lines and PureStem Progenitors for DTL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DTL_HUMAN, Q9NZJ0: Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm,
    cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Nuclear matrix-associated protein.
    Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA17106265

    Find genes that share ontologies with DTL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




    UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including DTL: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DTL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DTL (Q9NZJ01, 3 ENSP000003559584) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDB1Q165311, 3, ENSP000003017644EBI-1176075,EBI-350322 I2D: score=3 STRING: ENSP00000301764
    WDR5P619643, ENSP000003514464I2D: score=2 STRING: ENSP00000351446
    GRWD1Q9BQ673, ENSP000002532374I2D: score=1 STRING: ENSP00000253237
    KAT2AQ928303, ENSP000002259164I2D: score=1 STRING: ENSP00000225916
    CDKN1AP389363, ENSP000002447414I2D: score=1 STRING: ENSP00000244741
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination TAS17085480
    GO:0006260DNA replication IEA--
    GO:0006511ubiquitin-dependent protein catabolic process TAS17085480
    GO:0006513protein monoubiquitination IDA--
    GO:0006974cellular response to DNA damage stimulus IDA--

    Find genes that share ontologies with DTL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DTL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DTL gene (3 alternative transcripts): 
    NM_001286229.1  NM_001286230.1  NM_016448.3  

    Unigene Cluster for DTL:

    Denticleless E3 ubiquitin protein ligase homolog (Drosophila)
    Hs.656473  [show with all ESTs]
    Unigene Representative Sequence: NM_016448
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366991(uc009xdc.3 uc010ptb.2 uc001hiz.4) ENST00000475419
    ENST00000489149 ENST00000463791 ENST00000496442 ENST00000542077
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DTL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DTL (see all 29):
    hsa-miR-607 hsa-miR-3660 hsa-miR-1271 hsa-miR-200a hsa-miR-628-3p hsa-miR-507 hsa-miR-3680 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidDTL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DTL
    Predesigned siRNA for gene silencing in human, mouse, rat DTL
    Clone
    Products:
         
    OriGene clones in human, mouse for DTL (see all 6)
    OriGene ORF clones in mouse, rat for DTL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DTL (NM_016448)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DTL
    OriGene qSTAR qPCR primer pairs in human, mouse for DTL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTL
      QuantiTect SYBR Green Assays in human, mouse, rat DTL
      QuantiFast Probe-based Assays in human, mouse, rat DTL

    Additional mRNA sequence: 

    AF195765.1 AF345896.1 AK000742.1 AK027651.1 AK292343.1 AK299649.1 AK303346.1 BC033297.1 
    BC033540.1 DQ641253.1 

    9 DOTS entries:

    DT.99931047  DT.405249  DT.100777368  DT.100777372  DT.91751062  DT.100777366  DT.121378502  DT.75192561 
    DT.91743762 

    Selected AceView cDNA sequences (see all 147):

    AA913841 AL553783 AF195765 BM800170 AA581038 BC033297 BX416133 BU521670 
    BI257561 AA505890 BF508267 AA252326 AW339528 NM_016448 AI969579 AA730175 
    BG288414 BF512555 AW440579 AW069881 AA846697 AK000742 BQ431493 AA252192 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DTL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b
    SP1:              -                                                                       -                                 
    SP2:              -     -                                         -                       -                                 
    SP3:                                                                                                                        
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for DTL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DTL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGACTTTG
    DTL Expression
    About this image


    DTL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Bone Marrow
    DTL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DTL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656473

    UniProtKB/Swiss-Prot: DTL_HUMAN, Q9NZJ0
    Tissue specificity: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all
    hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the
    spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the
    expression in NT2 cell

        Pathway & Disease-focused RT2 Profiler PCR Array including DTL: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DTL
    OriGene qSTAR qPCR primer pairs in human, mouse for DTL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTL
    QuantiTect SYBR Green Assays in human, mouse, rat DTL
    QuantiFast Probe-based Assays in human, mouse, rat DTL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DTL gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtl1 , 5 denticleless homolog (Drosophila)1, 5 87.97(n)1
    89.57(a)1
      1 (96.44 cM)5
    768431  NM_029766.21  NP_084042.11 
     1915373655 
    chicken
    (Gallus gallus)
    Aves DTL1 denticleless E3 ubiquitin protein ligase homolog (Drosophila) 65.55(n)
    64.44(a)
      421373  NM_001031048.1  NP_001026219.1 
    lizard
    (Anolis carolinensis)
    Reptilia DTL6
    denticleless E3 ubiquitin protein ligase homolog (...
    57(a)
    1 ↔ 1
    1(238332217-238360696)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC755742 hypothetical protein MGC75574 76.26(n)    BC064851.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dtl2 denticleless homolog (Drosophila) 75.71(n)   192314  BC045316.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)dtl6
    lethal-(2)-denticleless
    27(a)
    1 ↔ 1
    2R(19590002-19592926)
    worm
    (Caenorhabditis elegans)
    Secernentea cdt-26
    Protein CDT-2 (cdt-2) mRNA, complete cds
    21(a)
    1 ↔ 1
    V(14987551-14991024) WBGene00011318


    ENSEMBL Gene Tree for DTL (if available)
    TreeFam Gene Tree for DTL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DTL gene
    1 SIMAP similar gene for DTL using alignment to 2 protein entries:     DTL_HUMAN (see all proteins):
    GNB5

    Find genes that share paralogs with DTL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DTL (see all 1364)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487395201,2
    --212211100(+) ATAGT-/GGCGG 
     GGGGGGG
    GGTGG
    1 -- cds10--------
    rs15789911,2
    C,F,A--212211103(+) agtggC/Tggtgg 1 -- int19Minor allele frequency- T:0.33NA WA CSA 15
    rs15789921,2
    C,F,A,H--212211174(+) cccagG/Ttcaaa 1 -- int121Minor allele frequency- C:0.09NS EA NA WA CSA 996
    rs1812154261,2
    --212211176(+) CAGGTC/GAAAAA 1 -- int10--------
    rs15789931,2
    C,F,A,H--212211284(+) acaatT/Gatttg 1 -- int122Minor allele frequency- G:0.47NS EA NA WA CSA 2243
    rs1149773691,2
    C,F--212211418(+) GCACTC/GACACA 1 -- int12Minor allele frequency- G:0.04WA NA 238
    rs757350921,2
    C,F--212211459(+) CACCAG/ATGAAC 1 -- int13Minor allele frequency- A:0.14WA CSA 122
    rs618285391,2
    C,F--212211476(+) TACACA/GTCTTT 1 -- int16Minor allele frequency- G:0.29NA CSA WA EA 364
    rs1853600371,2
    --212211483(+) CTTTGA/GCATGT 1 -- int10--------
    rs1480364771,2
    C--212211523(+) CCCTAC/TGAACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DTL (212208919 - 212280742 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DTL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4432CNV Insertion18451855
    nsv506979CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DTL
    DNA2.0 Custom Variant and Variant Library Synthesis for DTL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610617    OMIM disorders: --


    Find genes that share disorders with DTL           About GenesLikeMe

    Genetic Association Database (GAD): DTL
    Human Genome Epidemiology (HuGE) Navigator: DTL (1 document)

    Export disorders for DTL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DTL gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with DTL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation. (PubMed id 11278750)1, 2, 3, 9 Cheung W.M.... Ip N.Y. (J. Biol. Chem. 2001)
    2. L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. (PubMed id 16861906)1, 2, 9 Higa L.A.... Zhang H. (Cell Cycle 2006)
    3. Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. (PubMed id 23478441)1, 2 Rossi M....Pagano M. (Mol. Cell 2013)
    4. CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration. (PubMed id 23478445)1, 2 Abbas T....Dutta A. (Mol. Cell 2013)
    5. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PubMed id 18649358)1, 4 Ng D....Taylor P.R. (Int. J. Cancer 2008)
    6. CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. (PubMed id 18703516)1, 2 Nishitani H....Tsurimoto T. (J. Biol. Chem. 2008)
    7. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. (PubMed id 18794347)1, 2 Abbas T.... Dutta A. (Genes Dev. 2008)
    8. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (Mol. Cell 2006)
    9. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PubMed id 16964240)1, 2 Angers S.... Zheng N. (Nature 2006)
    10. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. (PubMed id 17085480)1, 2 Sansam C.L.... Lees J.A. (Genes Dev. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51514 HGNC: 30288 AceView: RAMP Ensembl:ENSG00000143476 euGenes: HUgn51514
    ECgene: DTL H-InvDB: DTL

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DTL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DTL gene:
    Search GeneIP for patents involving DTL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DTL  
     OriGene qPCR primer pairs and template standards for DTL   OriGene Protein Over-expression Lysate for DTL  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DTL  
     OriGene qSTAR qPCR primer pairs in human, mouse for DTL   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DTL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DTL   OriGene Custom Protein Services for DTL  

     
     
     Block miRNA regulation of human, mouse, rat DTL using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DTL
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTL Predesigned siRNA for gene silencing in human, mouse, rat DTL
     QuantiFast Probe-based Assays in human, mouse, rat DTL QuantiTect SYBR Green Assays in human, mouse, rat DTL
     PCR Arrays including human, mouse, rat DTL Search Chromatin IP Primers for DTL
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DTL  GeneGlobe Interaction Network for DTL
     Regulatory tfbs in DTL promoter
     GenScript Custom Purified and Recombinant Proteins Services for DTL GenScript cDNA clones with any tag delivered in your preferred vector for DTL
     GenScript Custom Assay Services for DTL GenScript Custom overexpressing Cell Line Services for DTL
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DTL
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DTL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DTL antibodies
     DTL lysates
     Antibodies for DTL
     See all of Abcam's Antibodies, Kits and Proteins for DTL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for DTL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTL
     SwitchGear 3'UTR luciferase reporter plasmids for DTL
     SwitchGear Promoter luciferase reporter plasmids for DTL
     ThermoFisher Antibodies for DTL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTL
     Browse compounds at ApexBio
     Search Addgene for plasmids for DTL
      Search eBioscience for proteins for DTL
      Search eBioscience for elisas for DTL
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DTL
     antibodies-online antibodies for DTL (34 products)
     antibodies-online kits for DTL (3 products)
     antibodies-online peptides for DTL
     antibodies-online proteins for DTL
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DTL gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4