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Aliases for DTHD1 Gene

Aliases for DTHD1 Gene

  • Death Domain Containing 1 2 3 5

External Ids for DTHD1 Gene

Previous GeneCards Identifiers for DTHD1 Gene

  • GC04P035961
  • GC04P035609

Summaries for DTHD1 Gene

Entrez Gene Summary for DTHD1 Gene

  • This gene encodes a protein which contains a death domain. Death domain-containing proteins function in signaling pathways and formation of signaling complexes, as well as the apoptosis pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

GeneCards Summary for DTHD1 Gene

DTHD1 (Death Domain Containing 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTHD1 Gene

Genomics for DTHD1 Gene

Regulatory Elements for DTHD1 Gene

Enhancers for DTHD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DTHD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DTHD1 Gene

Chromosome:
4
Start:
36,281,611 bp from pter
End:
36,345,756 bp from pter
Size:
64,146 bases
Orientation:
Plus strand

Genomic View for DTHD1 Gene

Genes around DTHD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTHD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTHD1 Gene

Proteins for DTHD1 Gene

  • Protein details for DTHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMT9-DTHD1_HUMAN
    Recommended name:
    Death domain-containing protein 1
    Protein Accession:
    Q6ZMT9
    Secondary Accessions:
    • B2RXK4
    • B4E2N7

    Protein attributes for DTHD1 Gene

    Size:
    781 amino acids
    Molecular mass:
    88329 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DTHD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTHD1 Gene

Proteomics data for DTHD1 Gene at MOPED

Post-translational modifications for DTHD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTHD1 Gene

No data available for DME Specific Peptides for DTHD1 Gene

Domains & Families for DTHD1 Gene

Protein Domains for DTHD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DTHD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMT9

UniProtKB/Swiss-Prot:

DTHD1_HUMAN :
  • Contains 1 death domain.
Domain:
  • Contains 1 death domain.
genes like me logo Genes that share domains with DTHD1: view

No data available for Gene Families for DTHD1 Gene

Function for DTHD1 Gene

genes like me logo Genes that share phenotypes with DTHD1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTHD1 Gene

Localization for DTHD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTHD1 Gene COMPARTMENTS Subcellular localization image for DTHD1 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DTHD1 Gene

Pathways & Interactions for DTHD1 Gene

SuperPathways for DTHD1 Gene

No Data Available

Interacting Proteins for DTHD1 Gene

Gene Ontology (GO) - Biological Process for DTHD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DTHD1 Gene

Drugs & Compounds for DTHD1 Gene

No Compound Related Data Available

Transcripts for DTHD1 Gene

mRNA/cDNA for DTHD1 Gene

Unigene Clusters for DTHD1 Gene

Death domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTHD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: -
SP3:

Relevant External Links for DTHD1 Gene

GeneLoc Exon Structure for
DTHD1
ECgene alternative splicing isoforms for
DTHD1

Expression for DTHD1 Gene

mRNA expression in normal human tissues for DTHD1 Gene

mRNA differential expression in normal tissues according to GTEx for DTHD1 Gene

This gene is overexpressed in Fallopian Tube (x5.4), Whole Blood (x4.8), Brain - Caudate (basal ganglia) (x4.8), Brain - Hypothalamus (x4.5), Cervix - Endocervix (x4.4), and Lung (x4.3).

Protein differential expression in normal tissues from HIPED for DTHD1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DTHD1 Gene



SOURCE GeneReport for Unigene cluster for DTHD1 Gene Hs.363407

genes like me logo Genes that share expression patterns with DTHD1: view

Protein tissue co-expression partners for DTHD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DTHD1 Gene

Orthologs for DTHD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DTHD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DTHD1 35
  • 87.02 (n)
  • 80.72 (a)
DTHD1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DTHD1 35
  • 85.65 (n)
  • 78.92 (a)
DTHD1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm17384 35
  • 81.12 (n)
  • 74.77 (a)
Dthd1 16
Gm17384 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DTHD1 35
  • 99.06 (n)
  • 98.08 (a)
DTHD1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DTHD1 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTHD1 35
  • 63.78 (n)
  • 53.51 (a)
DTHD1 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTHD1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734689 35
  • 61.11 (n)
  • 51.41 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536769 35
  • 49.38 (n)
  • 41.65 (a)
CU672227.1 36
  • 39 (a)
OneToOne
Species with no ortholog for DTHD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTHD1 Gene

ENSEMBL:
Gene Tree for DTHD1 (if available)
TreeFam:
Gene Tree for DTHD1 (if available)

Paralogs for DTHD1 Gene

No data available for Paralogs for DTHD1 Gene

Variants for DTHD1 Gene

Sequence variations from dbSNP and Humsavar for DTHD1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs16992035 - 36,284,155(+) CAAGA(A/G)GGGAA intron-variant, reference, missense
rs1995319 - 36,290,396(+) TGATG(A/T)TACTG reference, missense
rs12507599 - 36,308,427(+) CATCT(C/T)GTCAT reference, missense
rs9654132 - 36,339,131(+) CAACC(A/G)TCCAC reference, missense
rs993087 -- 36,321,516(+) cccag(A/C)tggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTHD1 Gene

Variant ID Type Subtype PubMed ID
nsv829907 CNV Gain 17160897
nsv4301 CNV Insertion 18451855
esv268366 CNV Insertion 20981092
esv1393189 CNV Insertion 17803354

Variation tolerance for DTHD1 Gene

Gene Damage Index Score: 10.73; 91.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTHD1 Gene

HapMap Linkage Disequilibrium report
DTHD1
Human Gene Mutation Database (HGMD)
DTHD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTHD1 Gene

Disorders for DTHD1 Gene

Relevant External Links for DTHD1

Genetic Association Database (GAD)
DTHD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTHD1

No disorders were found for DTHD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTHD1 Gene

Publications for DTHD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Autozygome-guided exome sequencing in retinal dystrophy patients reveals pathogenetic mutations and novel candidate disease genes. (PMID: 23105016) Abu-Safieh L. … Alkuraya F.S. (Genome Res. 2013) 3
  3. The death domain superfamily in intracellular signaling of apoptosis and inflammation. (PMID: 17201679) Park H.H. … Wu H. (Annu. Rev. Immunol. 2007) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for DTHD1 Gene

Sources for DTHD1 Gene

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