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Aliases for DTHD1 Gene

Aliases for DTHD1 Gene

  • Death Domain Containing 1 2 3

External Ids for DTHD1 Gene

Summaries for DTHD1 Gene

Entrez Gene Summary for DTHD1 Gene

  • This gene encodes a protein which contains a death domain. Death domain-containing proteins function in signaling pathways and formation of signaling complexes, as well as the apoptosis pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

GeneCards Summary for DTHD1 Gene

DTHD1 (Death Domain Containing 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTHD1 Gene

Genomics for DTHD1 Gene

Genomic Location for DTHD1 Gene

Start:
36,281,615 bp from pter
End:
36,345,756 bp from pter
Size:
64,142 bases
Orientation:
Plus strand

Genomic View for DTHD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTHD1 Gene

No data available for Regulatory Elements for DTHD1 Gene

Proteins for DTHD1 Gene

  • Protein details for DTHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMT9-DTHD1_HUMAN
    Recommended name:
    Death domain-containing protein 1
    Protein Accession:
    Q6ZMT9
    Secondary Accessions:
    • B2RXK4
    • B4E2N7

    Protein attributes for DTHD1 Gene

    Size:
    781 amino acids
    Molecular mass:
    88329 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DTHD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTHD1 Gene

Proteomics data for DTHD1 Gene at MOPED

Post-translational modifications for DTHD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTHD1 Gene

No data available for DME Specific Peptides for DTHD1 Gene

Domains for DTHD1 Gene

Protein Domains for DTHD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DTHD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMT9

UniProtKB/Swiss-Prot:

DTHD1_HUMAN
Domain:
  • Contains 1 death domain.:
    • Q6ZMT9
genes like me logo Genes that share domains with DTHD1: view

No data available for Gene Families for DTHD1 Gene

Function for DTHD1 Gene

Gene Ontology (GO) - Molecular Function for DTHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DTHD1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DTHD1 Gene

Localization for DTHD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTHD1 Gene COMPARTMENTS Subcellular localization image for DTHD1 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DTHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0008540 proteasome regulatory particle, base subcomplex IBA --
genes like me logo Genes that share ontologies with DTHD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DTHD1 Gene

Pathways for DTHD1 Gene

SuperPathways for DTHD1 Gene

No Data Available

Interacting Proteins for DTHD1 Gene

Gene Ontology (GO) - Biological Process for DTHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA --
GO:0070682 proteasome regulatory particle assembly IBA --
genes like me logo Genes that share ontologies with DTHD1: view

No data available for Pathways by source for DTHD1 Gene

Transcripts for DTHD1 Gene

mRNA/cDNA for DTHD1 Gene

Unigene Clusters for DTHD1 Gene

Death domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTHD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: -
SP3:

Relevant External Links for DTHD1 Gene

GeneLoc Exon Structure for
DTHD1
ECgene alternative splicing isoforms for
DTHD1

Expression for DTHD1 Gene

mRNA expression in normal human tissues for DTHD1 Gene

mRNA differential expression in normal tissues according to GTEx for DTHD1 Gene

This gene is overexpressed in Fallopian Tube (5.4), Whole Blood (4.8), Brain - Caudate (basal ganglia) (4.8), Brain - Hypothalamus (4.5), Cervix - Endocervix (4.4), and Lung (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DTHD1 Gene

SOURCE GeneReport for Unigene cluster for DTHD1 Gene Hs.363407

genes like me logo Genes that share expressions with DTHD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DTHD1 Gene

Orthologs for DTHD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DTHD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTHD1 35
  • 99.06 (n)
  • 98.08 (a)
DTHD1 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DTHD1 35
  • 87.02 (n)
  • 80.72 (a)
DTHD1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DTHD1 35
  • 85.65 (n)
  • 78.92 (a)
DTHD1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm17384 35
  • 81.12 (n)
  • 74.77 (a)
Gm17384 16
Gm17384 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DTHD1 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTHD1 35
  • 63.78 (n)
  • 53.51 (a)
DTHD1 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTHD1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734689 35
  • 61.11 (n)
  • 51.41 (a)
zebrafish
(Danio rerio)
Actinopterygii CU672227.1 36
  • 39 (a)
OneToOne
LOC100536769 35
  • 49.38 (n)
  • 41.65 (a)
Species with no ortholog for DTHD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTHD1 Gene

ENSEMBL:
Gene Tree for DTHD1 (if available)
TreeFam:
Gene Tree for DTHD1 (if available)

Paralogs for DTHD1 Gene

No data available for Paralogs for DTHD1 Gene

Variants for DTHD1 Gene

Sequence variations from dbSNP and Humsavar for DTHD1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs993087 -- 36,321,516(+) cccag(A/C)tggga intron-variant
rs993088 -- 36,321,549(+) GCTCA(A/G)GGCTC intron-variant
rs993089 -- 36,321,862(+) CTACT(A/C)GCCTC intron-variant
rs1501123 -- 36,327,631(-) AATGA(C/T)GTAAT intron-variant
rs1909914 -- 36,288,214(+) ctgtt(C/T)cagtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTHD1 Gene

Variant ID Type Subtype PubMed ID
nsv829907 CNV Gain 17160897
nsv4301 CNV Insertion 18451855
esv268366 CNV Insertion 20981092
esv1393189 CNV Insertion 17803354

Relevant External Links for DTHD1 Gene

HapMap Linkage Disequilibrium report
DTHD1
Human Gene Mutation Database (HGMD)
DTHD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTHD1 Gene

Disorders for DTHD1 Gene

(1) University of Copenhagen DISEASES for DTHD1 Gene

Relevant External Links for DTHD1

Genetic Association Database (GAD)
DTHD1
genes like me logo Genes that share disorders with DTHD1: view

No data available for UniProtKB/Swiss-Prot for DTHD1 Gene

Publications for DTHD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The death domain superfamily in intracellular signaling of apoptosis and inflammation. (PMID: 17201679) Park H.H. … Wu H. (Annu. Rev. Immunol. 2007) 3
  3. Autozygome-guided exome sequencing in retinal dystrophy patients reveals pathogenetic mutations and novel candidate disease genes. (PMID: 23105016) Abu-Safieh L. … Alkuraya F.S. (Genome Res. 2013) 3
  4. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48
  5. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 48

Products for DTHD1 Gene

Sources for DTHD1 Gene

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