Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DTHD1 Gene

protein-coding GIFtS: 44
GCID: GC04P036283

Death Domain Containing 1

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Death Domain Containing 1¹ ²
Death Domain-Containing Protein 1²

External Ids:	HGNC: 37261¹	Entrez Gene: 401124²	Ensembl: ENSG00000197057⁷	UniProtKB: Q6ZMT9³

ORGUL members:
	NONCODE¹⁴:n339903

Export aliases for DTHD1 gene to outside databases

Previous GC identifers: GC04P035961 GC04P035609

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DTHD1 Gene:

This gene encodes a protein which contains a death domain. Death domain-containing proteins function in signaling

pathways and formation of signaling complexes, as well as the apoptosis pathway. Alternative splicing results in

multiple transcript variants. (provided by RefSeq, Oct 2012)

GeneCards Summary for DTHD1 Gene:

DTHD1 (death domain containing 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with DTHD1 include fundus dystrophy.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.2 NT_016297.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for DTHD1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for DTHD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTHD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p14

DTHD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTHD1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P036283: view genomic region (about GC identifiers)

Start:	36,283,244 bp from pter	End:	36,347,378 bp from pter
Size:	64,135 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DTHD1_HUMAN, Q6ZMT9 (See protein sequence)

Recommended Name: Death domain-containing protein 1

Size: 781 amino acids; 88329 Da

Secondary accessions: B2RXK4 B4E2N7

Alternative splicing: 2 isoforms: Q6ZMT9-1 Q6ZMT9-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DTHD1: NX_Q6ZMT9

Explore proteomics data for DTHD1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q6ZMT9

DTHD1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001130008.2 NP_001164171.1

ENSEMBL proteins:

ENSP00000350103 ENSP00000424426 ENSP00000401597

Human Recombinant Protein Products for DTHD1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for DTHD1
	GenScript Custom Purified and Recombinant Proteins Services for DTHD1
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for DTHD1

DTHD1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for DTHD1
	GenScript Custom Superior Antibodies Services for DTHD1
	Novus Biologicals DTHD1 Antibody
	Abcam antibodies for DTHD1
	Cloud-Clone Corp. Antibodies for DTHD1
	Search ThermoFisher Antibodies for DTHD1
	Search LSBio for Antibodies for DTHD1

Assay Products for DTHD1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for DTHD1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DTHD1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for DTHD1 Cloud-Clone Corp. CLIAs for DTHD1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR011029 DEATH-like_dom

IPR000488 Death_domain

Graphical View of Domain Structure for InterPro Entry Q6ZMT9

ProtoNet protein and cluster: Q6ZMT9

1 Blocks protein domain: IPB000488 Death domain

UniProtKB/Swiss-Prot: DTHD1_HUMAN, Q6ZMT9

Similarity: Contains 1 death domain

DTHD1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

DTHD1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for DTHD1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DTHD1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DTHD1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DTHD1

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DTHD1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate DTHD1:
		hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-3935 hsa-miR-105 hsa-miR-573 hsa-miR-3662 hsa-miR-3674 hsa-miR-3668

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for DTHD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTHD1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DTHD1
			Sirion Biotech Customized adenovirus for overexpression of DTHD1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for DTHD1 (see all 9) OriGene ORF clones in mouse, rat for DTHD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DTHD1 (NM_001136536)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTHD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTHD1
		Sirion Biotech Customized lentivirus for stable overexpression of DTHD1 Customized lentivirus expression plasmids for stable overexpression of DTHD1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DTHD1
		Search LifeMap BioReagents cell lines for DTHD1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTHD1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DTHD1

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--

DTHD1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DTHD1

Search CenterWatch for drugs/clinical trials and news about DTHD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DTHD1 gene (2 alternative transcripts):

NM_001136536.4 NM_001170700.2

Unigene Cluster for DTHD1:

Death domain containing 1

Hs.363407 [show with all ESTs]

Unigene Representative Sequence: NM_001170700

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000357504 ENST00000507598 ENST00000506008 ENST00000503528(uc003gsv.3)

ENST00000456874(uc011bxy.2 uc021xne.1)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DTHD1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate DTHD1:
		hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-3935 hsa-miR-105 hsa-miR-573 hsa-miR-3662 hsa-miR-3674 hsa-miR-3668

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for DTHD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTHD1

Clone Products:		OriGene clones in human, mouse for DTHD1 (see all 9) OriGene ORF clones in mouse, rat for DTHD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DTHD1 (NM_001136536)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DTHD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTHD1
		Sirion Biotech Customized lentivirus for stable overexpression of DTHD1 Customized lentivirus expression plasmids for stable overexpression of DTHD1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for DTHD1
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat DTHD1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTHD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTHD1

Additional mRNA sequence:

AK094684.1 AK131492.1 AK304357.1 AK316523.1 BC157885.1 NR_073198.1

2 DOTS entries:

DT.102821129 DT.99933060

8 AceView cDNA sequences:

AK131492 AK094684 AI125835 AA954477 BM978838 BX102378 BU607760 CD694599

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DTHD1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b
SP1:			-														-		-
SP2:																					-
SP3:

ECgene alternative splicing isoforms for DTHD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DTHD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTCAGCACCA

About this image

See DTHD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DTHD1

SOURCE GeneReport for Unigene cluster: Hs.363407

SABiosciences Custom PCR Arrays for DTHD1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for DTHD1
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat DTHD1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTHD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTHD1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTHD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DTHD1 gene from 4/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gm17384^{1 , 5}	predicted gene, 17384^{1, 5}	81.12(n)¹ 74.77(a)¹		5 (32.04 cM)⁵ 100322896¹ NM_001170705.1¹ NP_001164176.1¹ 62813823⁵
chicken (Gallus gallus)	Aves	LOC100858463¹	death domain-containing protein 1-like	61.02(n) 49.43(a)		100858463 XM_003641216.1 XP_003641264.1
lizard (Anolis carolinensis)	Reptilia	DTHD1⁶	Uncharacterized protein	52(a)	1 ↔ 1	GL343598.1(129711-156475)
zebrafish (Danio rerio)	Actinopterygii	LOC100536769¹	death domain-containing protein 1-like	49.26(n) 41.59(a)		100536769 XM_003198997.1 XP_003199045.1

ENSEMBL Gene Tree for DTHD1 (if available)
TreeFam Gene Tree for DTHD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10718142^1,2	C	--	35629723(+)	`CTCCCT/-TTTTT`	2	--	int¹ trp³		2		NA CSA	4
rs200351550^1,2	C	--	35629723(+)	`CTCCCC/TTTTTT`	2	--	int¹		0	--	--	--	--
rs72596074^1,2	C	--	35631523(+)	`AGTTC-/ACGTAG`	2	--	int¹		0	--	--	--	--
rs145284723^1,2		--	36172423(+)	`TCTTAC/TATCTC`	1	--	us2k¹		0	--	--	--	--
rs138469561^1,2		--	36172445(+)	`ACATCC/TGCATC`	1	--	us2k¹		0	--	--	--	--
rs189039940^1,2		--	36172456(+)	`TCTACA/GGCACA`	1	--	us2k¹		0	--	--	--	--
rs181432532^1,2		--	36172478(+)	`ATTGCA/CGTCTG`	1	--	us2k¹		0	--	--	--	--
rs16992023^1,2	C,F,H	--	36172583(+)	`TCTGAC/TTCGTT`	1	--	us2k¹		9		NA NS EA CSA WA	682
rs185523682^1,2		--	36172666(+)	`TGATCA/GTATTA`	1	--	us2k¹		0	--	--	--	--
rs142023260^1,2		--	36172680(+)	`CCTATA/GCTGGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DTHD1 (36283244 - 36347378 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for DTHD1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv4301	CNV	Insertion	18451855
esv1393189	CNV	Insertion	17803354
esv268366	CNV	Insertion	20981092
nsv829907	CNV	Gain	17160897

Human Gene Mutation Database (HGMD): DTHD1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DTHD1

DNA2.0 Custom Variant and Variant Library Synthesis for DTHD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

2 diseases for DTHD1: About MalaCards

fundus dystrophy

1 disease from the University of Copenhagen DISEASES database for DTHD1:

Fundus dystrophy

DTHD1 for disorders About GeneDecksing

Genetic Association Database (GAD): DTHD1

Export disorders for DTHD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DTHD1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with DTHD1)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Autozygome-guided exome sequencing in retinal dystroph y patients reveals pathogenetic mutations and novel candidate disease genes. (PubMed id 23105016)¹ Abu-Safieh L....Alkuraya F.S. (2013)
Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. (PubMed id 20802204)⁴ Baranzini S.E....Pelletier D. (2010)
The death domain superfamily in intracellular signalin g of apoptosis and inflammation. (PubMed id 17201679)¹ Park H.H....Wu H. (2007)
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)⁴ Seshadri S....Wolf P.A. (2007)
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)⁴ Kathiresan S....Cupples L.A. (2007)
Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)⁴ Fox C.S....Atwood L.D. (2007)
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)⁴ Yang Q....O'Donnell C.J. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 401124	HGNC: 37261	AceView: FLJ16686	Ensembl:ENSG00000197057	euGenes: HUgn401124
ECgene: DTHD1	H-InvDB: DTHD1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DTHD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DTHD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DTHD1 gene:
Search GeneIP for patents involving DTHD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for DTHD1
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for DTHD1
	OriGene qSTAR qPCR primer pairs in human, mouse for DTHD1		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for DTHD1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DTHD1		OriGene Custom Protein Services for DTHD1

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DTHD1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DTHD1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTHD1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTHD1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTHD1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTHD1

	GenScript Custom Purified and Recombinant Proteins Services for DTHD1		GenScript cDNA clones with any tag delivered in your preferred vector for DTHD1
	GenScript Custom Assay Services for DTHD1		GenScript Custom Superior Antibodies Services for DTHD1
	GenScript Custom overexpressing Cell Line Services for DTHD1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for DTHD1
	Search Chromatin IP Primers for DTHD1
	RT² qPCR Primer Assay in human, mouse / rat DTHD1
	Search GNC Networks for DTHD1
	SABiosciences Custom PCR Arrays for DTHD1

Search Tocris compounds for DTHD1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DTHD1 antibodies

	Antibodies for DTHD1
	See all of Abcam's Antibodies, Kits and Proteins for DTHD1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for DTHD1
	Antibodies for DTHD1
	ELISAs for DTHD1
	CLIAs for DTHD1

Search LifeMap BioReagents cell lines for DTHD1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTHD1

	Browse SwitchGear 3'UTR luciferase reporter plasmids for DTHD1
	Browse SwitchGear Promoter luciferase reporter plasmids for DTHD1

Search ThermoFisher Antibodies for DTHD1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTHD1

	inGenious Targeting Laboratory - Custom generated mouse model solutions for DTHD1
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DTHD1

Customized:

	lentivirus for stable overexpression of DTHD1
	lentivirus expression plasmids for stable overexpression of DTHD1
	adenovirus for overexpression of DTHD1

Search LSBio for Antibodies for DTHD1

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DTHD1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

DTHD1 Gene

Death Domain Containing 1

Aliases
for DTHD1 gene

Summaries
for DTHD1 gene

Genomic Views
for DTHD1 gene

Proteins
for DTHD1 gene

Protein Domains /
Families
for DTHD1 gene

Function
for DTHD1 gene

Pathways & Interactions
for DTHD1 gene

Drugs & Compounds
for DTHD1 gene

Transcripts
for DTHD1 gene

Expression
for DTHD1 gene

Orthologs
for DTHD1 gene

Paralogs
for DTHD1 gene

Genomic Variants
for DTHD1 gene

Disorders / Diseases
for DTHD1 gene

Publications
for DTHD1 gene

External Searches for DTHD1 gene

Genome Databases showing DTHD1 gene

Other Databases showing DTHD1 gene

Specialized Databases showing DTHD1 gene

Intellectual Property
for DTHD1 gene

Products
for DTHD1 gene

View Random Gene

Advanced Search

Export list of displayed genes

DTHD1 Gene

Death Domain Containing 1

Aliasesfor DTHD1 gene

Summariesfor DTHD1 gene

Genomic Viewsfor DTHD1 gene

Proteinsfor DTHD1 gene

Protein Domains /Familiesfor DTHD1 gene

Functionfor DTHD1 gene

Pathways & Interactionsfor DTHD1 gene

Drugs & Compoundsfor DTHD1 gene

Transcriptsfor DTHD1 gene

Expression for DTHD1 gene

Orthologsfor DTHD1 gene

Paralogsfor DTHD1 gene

Genomic Variantsfor DTHD1 gene

Disorders / Diseasesfor DTHD1 gene

Publicationsfor DTHD1 gene

External Searches for DTHD1 gene

Genome Databases showing DTHD1 gene

Other Databases showing DTHD1 gene

Specialized Databases showing DTHD1 gene

Intellectual Propertyfor DTHD1 gene

Productsfor DTHD1 gene

View Random Gene

Aliases
for DTHD1 gene

Summaries
for DTHD1 gene

Genomic Views
for DTHD1 gene

Proteins
for DTHD1 gene

Protein Domains /
Families
for DTHD1 gene

Function
for DTHD1 gene

Pathways & Interactions
for DTHD1 gene

Drugs & Compounds
for DTHD1 gene

Transcripts
for DTHD1 gene

Expression
for DTHD1 gene

Orthologs
for DTHD1 gene

Paralogs
for DTHD1 gene

Genomic Variants
for DTHD1 gene

Disorders / Diseases
for DTHD1 gene

Publications
for DTHD1 gene

Intellectual Property
for DTHD1 gene

Products
for DTHD1 gene