DTHD1 Gene
protein-coding GIFtS: 41
GCID: GC04P036283
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death domain containing 1
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Aliases
for DTHD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Death Domain Containing 11 2 | | FLJ166861 | | Death Domain-Containing Protein 12 |
| External Ids: | HGNC: 372611 | Entrez Gene: 4011242 | Ensembl: ENSG000001970577 | UniProtKB: Q6ZMT93 | | ORGUL members: | |
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| NONCODE:n339903 | |
Export aliases for DTHD1 gene to outside databasesPrevious GC identifers: GC04P035961 GC04P035609
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Summaries
for DTHD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DTHD1:
This gene encodes a protein which contains a death domain. Death domain-containing proteins function in signalingpathways and formation of signaling complexes, as well as the apoptosis pathway. Alternative splicing results inmultiple transcript variants. (provided by RefSeq, Oct 2012)
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Genomic Views
for DTHD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016297.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DTHD1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DTHD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTHD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p14 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p14DTHD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P036283: view genomic region
(about GC identifiers)
Start:
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36,283,244 bp from pter |
End:
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36,347,378 bp from pter |
Size:
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64,135 bases |
Orientation:
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plus strand |
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Proteins
for DTHD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DTHD1_HUMAN, Q6ZMT9 (See
protein sequence)Recommended Name: Death domain-containing protein 1 Size: 781 amino acids; 88329 Da
Secondary accessions: B2RXK4 B4E2N7Alternative splicing: 2 isoforms: Q6ZMT9-1 Q6ZMT9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DTHD1: NX_Q6ZMT9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZMT9
DTHD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001164171.1
ENSEMBL proteins: ENSP00000350103 ENSP00000424426 ENSP00000401597
Human Recombinant Protein Products:
DTHD1 Antibody Products:
Assay Products for DTHD1: |
Protein
Domains /
Families
for DTHD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DTHD1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZMT9ProtoNet protein and cluster: Q6ZMT9 1 Blocks protein family: IPB000488 Death domain
UniProtKB/Swiss-Prot: DTHD1_HUMAN, Q6ZMT9Similarity: Contains 1 death domain |
Function
for DTHD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DTHD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DTHD1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DTHD1 (NM_001136536) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DTHD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTHD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTHD1 |
|
Pathways & Interactions
for DTHD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DTHD1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- |
DTHD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DTHD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DTHD1
Search CenterWatch for drugs/clinical trials and news about DTHD1
|
Transcripts
for DTHD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DTHD1 gene (2 alternative transcripts): NM_001170700.2 NM_001136536.3 Unigene Cluster for DTHD1: Death domain containing 1 Hs.363407 [show with all ESTs]Unigene Representative Sequence: NM_0011707005 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357504 ENST00000507598 ENST00000506008 ENST00000503528(uc003gsv.3)
ENST00000456874(uc011bxy.2 uc021xne.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DTHD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DTHD1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DTHD1 (NM_001136536) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DTHD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTHD1 |
Additional cDNA sequence: AK094684.1 AK131492.1 AK304357.1 AK316523.1 BC157885.1 NR_073198.1 2 DOTS entries: DT.102821129 DT.99933060 8 AceView cDNA sequences: AK131492 AI125835 AK094684 BM978838 AA954477 CD694599 BX102378 BU607760
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for DTHD1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
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| SP1: | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DTHD1
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Expression
for DTHD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DTHD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAGCACCA
About this image
See DTHD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DTHD1
SOURCE GeneReport for Unigene cluster: Hs.363407
SABiosciences Custom PCR Arrays for DTHD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DTHD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DTHD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTHD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTHD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTHD1 |
Orthologs
for DTHD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DTHD1 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for DTHD1 (if available)
TreeFam Gene Tree for DTHD1 (if available) |
Paralogs
for DTHD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DTHD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DTHD1
2 CNVs: 80246 92038 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DTHD1 |
|
Disorders
/ Diseases
for DTHD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 DTHD1 for disorders About MalaCards
DTHD1 for disorders About GeneDecksing
1 disease from the University of Copenhagen DISEASES database for DTHD1:Fundus dystrophy Export disorders for DTHD1 gene to outside databases
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Publications
for DTHD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DTHD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DTHD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for DTHD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DTHD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DTHD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DTHD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DTHD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DTHD1 gene:
Search GeneIP for patents involving DTHD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DTHD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DTHD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DTHD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DTHD1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DTHD1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DTHD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DTHD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DTHD1 | | OriGene Custom Protein Services for DTHD1 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DTHD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DTHD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTHD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DTHD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DTHD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DTHD1 |
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 |  |  |  | |
| | | | Search Tocris compounds for DTHD1 |
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 | | | DTHD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTHD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for DTHD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DTHD1 |
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