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Aliases for DTD2 Gene

Aliases for DTD2 Gene

  • D-Tyrosyl-TRNA Deacylase 2 (Putative) 2 3 5
  • C14orf126 3 4
  • Chromosome 14 Open Reading Frame 126 2
  • D-Tyrosyl-TRNA Deacylase 2 4
  • EC 3.1.-.- 4

External Ids for DTD2 Gene

Previous HGNC Symbols for DTD2 Gene

  • C14orf126

Previous GeneCards Identifiers for DTD2 Gene

  • GC14M031917

Summaries for DTD2 Gene

GeneCards Summary for DTD2 Gene

DTD2 (D-Tyrosyl-TRNA Deacylase 2 (Putative)) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on ester bonds and D-tyrosyl-tRNA(Tyr) deacylase activity. An important paralog of this gene is ENSG00000203546.

UniProtKB/Swiss-Prot for DTD2 Gene

  • Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTD2 Gene

Genomics for DTD2 Gene

Regulatory Elements for DTD2 Gene

Promoters for DTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DTD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DTD2 Gene

Chromosome:
14
Start:
31,446,036 bp from pter
End:
31,457,510 bp from pter
Size:
11,475 bases
Orientation:
Minus strand

Genomic View for DTD2 Gene

Genes around DTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTD2 Gene

Proteins for DTD2 Gene

  • Protein details for DTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FN9-DTD2_HUMAN
    Recommended name:
    Probable D-tyrosyl-tRNA(Tyr) deacylase 2
    Protein Accession:
    Q96FN9
    Secondary Accessions:
    • D3DS87

    Protein attributes for DTD2 Gene

    Size:
    168 amino acids
    Molecular mass:
    18660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DTD2 Gene

Proteomics data for DTD2 Gene at MOPED

Post-translational modifications for DTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DTD2 Gene

Domains & Families for DTD2 Gene

Protein Domains for DTD2 Gene

Suggested Antigen Peptide Sequences for DTD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FN9

UniProtKB/Swiss-Prot:

DTD2_HUMAN :
  • Belongs to the DTD family.
Family:
  • Belongs to the DTD family.
genes like me logo Genes that share domains with DTD2: view

No data available for Gene Families for DTD2 Gene

Function for DTD2 Gene

Molecular function for DTD2 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential).

Enzyme Numbers (IUBMB) for DTD2 Gene

Gene Ontology (GO) - Molecular Function for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002161 aminoacyl-tRNA editing activity IBA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
genes like me logo Genes that share ontologies with DTD2: view
genes like me logo Genes that share phenotypes with DTD2: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTD2 Gene

Localization for DTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTD2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTD2 Gene COMPARTMENTS Subcellular localization image for DTD2 gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DTD2 Gene

Pathways & Interactions for DTD2 Gene

SuperPathways for DTD2 Gene

No Data Available

Interacting Proteins for DTD2 Gene

Gene Ontology (GO) - Biological Process for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DTD2: view

No data available for Pathways by source and SIGNOR curated interactions for DTD2 Gene

Drugs & Compounds for DTD2 Gene

No Compound Related Data Available

Transcripts for DTD2 Gene

mRNA/cDNA for DTD2 Gene

Unigene Clusters for DTD2 Gene

D-tyrosyl-tRNA deacylase 2 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for DTD2 Gene

GeneLoc Exon Structure for
DTD2
ECgene alternative splicing isoforms for
DTD2

Expression for DTD2 Gene

mRNA expression in normal human tissues for DTD2 Gene

Protein differential expression in normal tissues from HIPED for DTD2 Gene

This gene is overexpressed in Bone marrow stromal cell (20.9) and Salivary gland (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DTD2 Gene



SOURCE GeneReport for Unigene cluster for DTD2 Gene Hs.116014

genes like me logo Genes that share expression patterns with DTD2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DTD2 Gene

Orthologs for DTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTD2 35
  • 99.6 (n)
  • 99.4 (a)
-- 36
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 89 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
C21H14orf126 35
  • 89.88 (n)
  • 89.29 (a)
dog
(Canis familiaris)
Mammalia DTD2 35
  • 89.29 (n)
  • 89.88 (a)
-- 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dtd2 36
  • 85 (a)
OneToMany
Dtd2 16
Dtd2 35
  • 79.56 (n)
  • 84.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dtd2 35
  • 78.97 (n)
  • 85.12 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 72 (a)
OneToMany
C14ORF126 35
  • 73.58 (n)
  • 75.47 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.12995 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dtd2 35
  • 61.11 (n)
  • 60.71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12205 35
zebrafish
(Danio rerio)
Actinopterygii dtd2 36
  • 63 (a)
OneToMany
dtd2 35
  • 64.78 (n)
  • 66.04 (a)
Species with no ortholog for DTD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTD2 Gene

ENSEMBL:
Gene Tree for DTD2 (if available)
TreeFam:
Gene Tree for DTD2 (if available)

Paralogs for DTD2 Gene

Paralogs for DTD2 Gene

genes like me logo Genes that share paralogs with DTD2: view

Variants for DTD2 Gene

Sequence variations from dbSNP and Humsavar for DTD2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17097904 - 31,457,378(+) AATCC(A/C/G)GCTAC reference, missense
rs4981101 -- 31,455,884(+) TTAGA(C/T)AGGAT intron-variant
rs8016858 -- 31,455,638(+) gtgca(A/G)tggcg intron-variant
rs17097901 -- 31,454,477(+) AACAA(C/T)AGGCA intron-variant
rs12432479 -- 31,454,305(+) GTACA(A/C/T)GATAG intron-variant

Variation tolerance for DTD2 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTD2 Gene

HapMap Linkage Disequilibrium report
DTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DTD2 Gene

Disorders for DTD2 Gene

Relevant External Links for DTD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTD2

No disorders were found for DTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTD2 Gene

Publications for DTD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for DTD2 Gene

Sources for DTD2 Gene

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