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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DTD2 Gene

protein-coding   GIFtS: 39
GCID: GC14M031917

D-Tyrosyl-TRNA Deacylase 2 (Putative)

(Previous name: chromosome 14 open reading frame 126)
(Previous symbol: C14orf126)
  Search for DTD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
D-Tyrosyl-TRNA Deacylase 2 (Putative)1 2
C14orf1261 2 3
Chromosome 14 Open Reading Frame 1261
Probable D-Tyrosyl-TRNA(Tyr) Deacylase 22
EC 3.1.-.-3
D-Tyrosyl-TRNA Deacylase 23

External Ids:    HGNC: 202771   Entrez Gene: 1124872   Ensembl: ENSG000001294807   UniProtKB: Q96FN93   

Export aliases for DTD2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DTD2 Gene: 
DTD2 (D-tyrosyl-tRNA deacylase 2 (putative)) is a protein-coding gene. GO annotations related to this gene include hydrolase activity, acting on ester bonds and molecular_function. An important paralog of this gene is ENSG00000203546.

UniProtKB/Swiss-Prot: DTD2_HUMAN, Q96FN9
Function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against
a harmful effect of D-tyrosine (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DTD2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DTD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DTD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

DTD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTD2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M031917:  view genomic region     (about GC identifiers)

Start:
31,915,242 bp from pter      End:
31,926,716 bp from pter
Size:
11,475 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DTD2_HUMAN, Q96FN9 (See protein sequence)
Recommended Name: Probable D-tyrosyl-tRNA(Tyr) deacylase 2  
Size: 168 amino acids; 18660 Da
Subcellular location: Cytoplasm (Potential)
Secondary accessions: D3DS87

Explore the universe of human proteins at neXtProt for DTD2: NX_Q96FN9

Explore proteomics data for DTD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96FN9

  • DTD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DTD2 Protein Expression
    REFSEQ proteins: NP_542395.1  
    ENSEMBL proteins: 
     ENSP00000312224   ENSP00000449624   ENSP00000348503  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--

    DTD2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR023509 DTD-like_dom
     IPR003732 DTyrtRNA_deacyls

    Graphical View of Domain Structure for InterPro Entry Q96FN9

    ProtoNet protein and cluster: Q96FN9

    1 Blocks protein domain: IPB003732 D-tyrosyl-tRNA(Tyr) deacylase

    UniProtKB/Swiss-Prot: DTD2_HUMAN, Q96FN9
    Similarity: Belongs to the DTD family


    DTD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DTD2_HUMAN, Q96FN9
    Function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against
    a harmful effect of D-tyrosine (Potential)

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0016788hydrolase activity, acting on ester bonds IEA--
         
    DTD2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DTD2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for DTD2 (ENSP000003122244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0019478D-amino acid catabolic process IEA--

    DTD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DTD2

    Search CenterWatch for drugs/clinical trials and news about DTD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DTD2 gene: 
    NM_080664.2  

    Unigene Cluster for DTD2:

    D-tyrosyl-tRNA deacylase 2 (putative)
    Hs.116014  [show with all ESTs]
    Unigene Representative Sequence: NM_080664
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310850(uc001wrj.3) ENST00000549850 ENST00000356180
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK022703.1 AK055367.1 

    6 DOTS entries:

    DT.91918275  DT.211371  DT.95371243  DT.91658225  DT.100022644  DT.40270027 

    24/79 AceView cDNA sequences (see all 79):

    AI381726 AA453268 AA495859 BG370429 BQ065235 AI400522 BC062720 CA444474 
    AA649027 AA234653 AA424819 BE782443 AI375899 AW103113 CD104134 AA453370 
    BI549501 BI603138 BM984416 AI336132 BG613464 BU944885 AK055367 AI867464 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DTD2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for DTD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DTD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DTD2 Expression
    About this image


    See DTD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DTD2

    SOURCE GeneReport for Unigene cluster: Hs.116014
        SABiosciences Custom PCR Arrays for DTD2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DTD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DTD2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtd21 , 5 RIKEN cDNA 6530401N04 gene5
    D-tyrosyl-tRNA deacylase 21
    79.56(n)1
    84.52(a)1
      12 (22.11 cM)5
    3280921  NM_029545.21  NP_083821.11 
     519883125 
    chicken
    (Gallus gallus)
    Aves C5H14orf1261 chromosome 5 open reading frame, human C14orf126 73.58(n)
    75.47(a)
      770817  XM_001234139.2  XP_001234140.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    73(a)
    1 → many
    2(56788458-56792605)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.129952 Xenopus laevis transcribed sequence with weak similarity more 73.98(n)    BJ098828.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1007951 zgc:100795 64.57(n)
    66.04(a)
      445510  NM_001004011.1  NP_001004011.1 


    ENSEMBL Gene Tree for DTD2 (if available)
    TreeFam Gene Tree for DTD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DTD2 gene
    ENSG000002035462  

    DTD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/283 SNPs in DTD2 are shown (see all 283)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928733681,2
    C--31914851(+) ACAGCA/GCTATC 1 -- int10--------
    rs766818691,2
    C--31914967(+) CGACTG/TCATTT 1 -- int10--------
    rs1153221941,2
    F--31914971(+) TTCATT/CTGCCT 1 -- int11Minor allele frequency- C:0.04WA 118
    rs101361751,2
    C,F,H--31915060(+) aattgT/Gtattc 1 -- int110Minor allele frequency- G:0.03NS EA NA WA 1212
    rs351633161,2
    C--31915093(+) TTTTT-/AAAGAGG 1 -- int10--------
    rs714309591,2
    C--31915093(+) TTTTTAA/-AGAGG 1 -- int11Minor allele frequency- -:0.50NA 2
    rs2006031001,2
    C--31915094(-) CCTCTC/TTAAAA 1 -- int10--------
    rs1844412271,2
    --31915122(+) ACAGCA/CATCAA 1 -- int10--------
    rs170978921,2
    C,F,H--31915216(+) CCTCTT/CTGGAG 1 -- int124Minor allele frequency- C:0.24NA NS EA WA CSA 2488
    rs1884406041,2
    --31915226(+) GAAACC/TTTGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for DTD2 (31915242 - 31926716 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DTD2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DTD2
    DNA2.0 Custom Variant and Variant Library Synthesis for DTD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DTD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DTD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    6. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 112487 HGNC: 20277 AceView: C14orf126 Ensembl:ENSG00000129480 euGenes: HUgn112487
    ECgene: DTD2 H-InvDB: DTD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DTD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DTD2 gene:
    Search GeneIP for patents involving DTD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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