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Aliases for DTD2 Gene

Aliases for DTD2 Gene

  • D-Tyrosyl-TRNA Deacylase 2 (Putative) 2 3
  • C14orf126 3 4
  • Probable D-Tyrosyl-TRNA(Tyr) Deacylase 2 3
  • Chromosome 14 Open Reading Frame 126 2
  • D-Tyrosyl-TRNA Deacylase 2 4
  • EC 3.1.-.- 4

External Ids for DTD2 Gene

Previous Symbols for DTD2 Gene

  • C14orf126

Summaries for DTD2 Gene

GeneCards Summary for DTD2 Gene

DTD2 (D-Tyrosyl-TRNA Deacylase 2 (Putative)) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on ester bonds. An important paralog of this gene is ENSG00000203546.

UniProtKB/Swiss-Prot for DTD2 Gene

  • Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTD2 Gene

Genomics for DTD2 Gene

Genomic Location for DTD2 Gene

Start:
31,446,036 bp from pter
End:
31,457,510 bp from pter
Size:
11,475 bases
Orientation:
Minus strand

Genomic View for DTD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTD2 Gene

No data available for Regulatory Elements for DTD2 Gene

Proteins for DTD2 Gene

  • Protein details for DTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FN9-DTD2_HUMAN
    Recommended name:
    Probable D-tyrosyl-tRNA(Tyr) deacylase 2
    Protein Accession:
    Q96FN9
    Secondary Accessions:
    • D3DS87

    Protein attributes for DTD2 Gene

    Size:
    168 amino acids
    Molecular mass:
    18660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DTD2 Gene

Proteomics data for DTD2 Gene at MOPED

Post-translational modifications for DTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DTD2 Gene

Domains for DTD2 Gene

Protein Domains for DTD2 Gene

UniProtKB/Swiss-Prot:

DTD2_HUMAN
Family:
  • Belongs to the DTD family.:
    • Q96FN9
genes like me logo Genes that share domains with DTD2: view

No data available for Gene Families for DTD2 Gene

Function for DTD2 Gene

Molecular function for DTD2 Gene

UniProtKB/Swiss-Prot Function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential).

Enzyme Numbers (IUBMB) for DTD2 Gene

Gene Ontology (GO) - Molecular Function for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002161 aminoacyl-tRNA editing activity IBA --
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 22939629
GO:0016788 hydrolase activity, acting on ester bonds --
GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity IBA --
genes like me logo Genes that share ontologies with DTD2: view

miRNA for DTD2 Gene

miRTarBase miRNAs that target DTD2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DTD2 Gene

Localization for DTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTD2 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DTD2: view

Pathways for DTD2 Gene

SuperPathways for DTD2 Gene

No Data Available

Interacting Proteins for DTD2 Gene

Gene Ontology (GO) - Biological Process for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006399 tRNA metabolic process IBA --
GO:0006450 regulation of translational fidelity IBA --
GO:0008150 biological_process ND --
GO:0019478 D-amino acid catabolic process IEA --
genes like me logo Genes that share ontologies with DTD2: view

No data available for Pathways by source for DTD2 Gene

Transcripts for DTD2 Gene

mRNA/cDNA for DTD2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(79) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DTD2 Gene

D-tyrosyl-tRNA deacylase 2 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for DTD2 Gene

GeneLoc Exon Structure for
DTD2
ECgene alternative splicing isoforms for
DTD2

Expression for DTD2 Gene

mRNA expression in normal human tissues for DTD2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DTD2 Gene

SOURCE GeneReport for Unigene cluster for DTD2 Gene Hs.116014

genes like me logo Genes that share expressions with DTD2: view

Orthologs for DTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 99 (a)
OneToMany
DTD2 36
  • 99.6 (n)
  • 99.4 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 89 (a)
ManyToMany
-- 37
  • 89 (a)
ManyToMany
C21H14orf126 36
  • 89.88 (n)
  • 89.29 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 90 (a)
OneToMany
DTD2 36
  • 89.29 (n)
  • 89.88 (a)
mouse
(Mus musculus)
Mammalia Dtd2 36
  • 79.56 (n)
  • 84.52 (a)
Dtd2 16
Dtd2 37
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dtd2 36
  • 78.97 (n)
  • 85.12 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 72 (a)
OneToMany
C14ORF126 36
  • 73.58 (n)
  • 75.47 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 73 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.12995 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dtd2 36
  • 61.11 (n)
  • 60.71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12205 36
zebrafish
(Danio rerio)
Actinopterygii dtd2 36
  • 64.78 (n)
  • 66.04 (a)
dtd2 37
  • 63 (a)
OneToMany
Species with no ortholog for DTD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTD2 Gene

ENSEMBL:
Gene Tree for DTD2 (if available)
TreeFam:
Gene Tree for DTD2 (if available)

Paralogs for DTD2 Gene

Paralogs for DTD2 Gene

genes like me logo Genes that share paralogs with DTD2: view

Variants for DTD2 Gene

Sequence variations from dbSNP and Humsavar for DTD2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1888576 -- 31,459,450(+) ACAAT(A/G)CTGAA upstream-variant-2KB
rs4981101 -- 31,455,884(+) TTAGA(C/T)AGGAT intron-variant
rs8016858 -- 31,455,638(+) gtgca(A/G)tggcg intron-variant
rs8017777 -- 31,455,644(+) tggcg(C/T)gatct intron-variant
rs8017781 -- 31,455,650(+) gatct(C/T)ggctc intron-variant

Relevant External Links for DTD2 Gene

HapMap Linkage Disequilibrium report
DTD2

No data available for Structural Variations from Database of Genomic Variants (DGV) for DTD2 Gene

Disorders for DTD2 Gene

No disorders were found for DTD2 Gene.

No data available for UniProtKB/Swiss-Prot for DTD2 Gene

Publications for DTD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4

Products for DTD2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DTD2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DTD2
    • Block miRNA regulation of DTD2 using miScript Target Protectors

    Sources for DTD2 Gene

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