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Aliases for DTD2 Gene

Aliases for DTD2 Gene

  • D-Tyrosyl-TRNA Deacylase 2 (Putative) 2 3 5
  • C14orf126 3 4
  • Probable D-Tyrosyl-TRNA(Tyr) Deacylase 2 3
  • Chromosome 14 Open Reading Frame 126 2
  • D-Tyrosyl-TRNA Deacylase 2 4
  • EC 3.1.-.- 4

External Ids for DTD2 Gene

Previous HGNC Symbols for DTD2 Gene

  • C14orf126

Previous GeneCards Identifiers for DTD2 Gene

  • GC14M031917

Summaries for DTD2 Gene

GeneCards Summary for DTD2 Gene

DTD2 (D-Tyrosyl-TRNA Deacylase 2 (Putative)) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on ester bonds and D-tyrosyl-tRNA(Tyr) deacylase activity. An important paralog of this gene is ENSG00000203546.

UniProtKB/Swiss-Prot for DTD2 Gene

  • Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTD2 Gene

Genomics for DTD2 Gene

Regulatory Elements for DTD2 Gene

Enhancers for DTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F032134 0.8 ENCODE 10.4 -677.4 -677350 0.1 PKNOX1 ZNF133 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 KLF7 FOS ZNF263 LOC100533787 ENSG00000257472 ENSG00000258196 ENSG00000257155 RNU6-7 RNU6-8 ARHGAP5 DTD2 GC14P032154 ARHGAP5-AS1
GH14F031505 1.1 Ensembl ENCODE 9.8 -48.1 -48083 1.2 ZNF680 NR2F2 DTD2 NUBPL LOC105370438 PIR47875
GH14F031456 0.7 ENCODE 9.6 +0.3 348 2.3 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 HEATR5A LOC101927124 RPL21P5 UBE2CP1 DTD2 HECTD1 ENSG00000203546 GC14P031438
GH14F031418 0.2 ENCODE 8.4 +37.0 37039 3.9 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 RPL21P5 LOC101927124 UBE2CP1 DTD2 ENSG00000203546 HEATR5A
GH14F031461 0.4 ENCODE 8 -5.1 -5138 1.4 ZNF366 LOC101927124 HEATR5A DTD2 GC14M031463
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DTD2 on UCSC Golden Path with GeneCards custom track

Promoters for DTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000415999 410 2201 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for DTD2 Gene

Chromosome:
14
Start:
31,446,036 bp from pter
End:
31,457,510 bp from pter
Size:
11,475 bases
Orientation:
Minus strand

Genomic View for DTD2 Gene

Genes around DTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTD2 Gene

Proteins for DTD2 Gene

  • Protein details for DTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FN9-DTD2_HUMAN
    Recommended name:
    Probable D-tyrosyl-tRNA(Tyr) deacylase 2
    Protein Accession:
    Q96FN9
    Secondary Accessions:
    • D3DS87

    Protein attributes for DTD2 Gene

    Size:
    168 amino acids
    Molecular mass:
    18660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DTD2 Gene

Post-translational modifications for DTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DTD2 Gene

Domains & Families for DTD2 Gene

Protein Domains for DTD2 Gene

Suggested Antigen Peptide Sequences for DTD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FN9

UniProtKB/Swiss-Prot:

DTD2_HUMAN :
  • Belongs to the DTD family.
Family:
  • Belongs to the DTD family.
genes like me logo Genes that share domains with DTD2: view

No data available for Gene Families for DTD2 Gene

Function for DTD2 Gene

Molecular function for DTD2 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential).

Enzyme Numbers (IUBMB) for DTD2 Gene

Gene Ontology (GO) - Molecular Function for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002161 aminoacyl-tRNA editing activity IBA --
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 22939629
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
genes like me logo Genes that share ontologies with DTD2: view
genes like me logo Genes that share phenotypes with DTD2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTD2 Gene

Localization for DTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTD2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTD2 Gene COMPARTMENTS Subcellular localization image for DTD2 gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DTD2: view

Pathways & Interactions for DTD2 Gene

SuperPathways for DTD2 Gene

No Data Available

Interacting Proteins for DTD2 Gene

Gene Ontology (GO) - Biological Process for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006399 tRNA metabolic process IBA --
GO:0006450 regulation of translational fidelity IEA --
GO:0008150 biological_process ND --
GO:0019478 D-amino acid catabolic process IEA --
genes like me logo Genes that share ontologies with DTD2: view

No data available for Pathways by source and SIGNOR curated interactions for DTD2 Gene

Transcripts for DTD2 Gene

mRNA/cDNA for DTD2 Gene

Unigene Clusters for DTD2 Gene

D-tyrosyl-tRNA deacylase 2 (putative):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for DTD2 Gene

GeneLoc Exon Structure for
DTD2
ECgene alternative splicing isoforms for
DTD2

Expression for DTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DTD2 Gene

Protein differential expression in normal tissues from HIPED for DTD2 Gene

This gene is overexpressed in Bone marrow stromal cell (20.9) and Salivary gland (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DTD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of DTD2 Gene:

DTD2

SOURCE GeneReport for Unigene cluster for DTD2 Gene:

Hs.116014
genes like me logo Genes that share expression patterns with DTD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DTD2 Gene

Orthologs for DTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTD2 34
  • 99.6 (n)
-- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 90 (a)
OneToMany
DTD2 34
  • 89.29 (n)
cow
(Bos Taurus)
Mammalia C21H14orf126 34
  • 89.88 (n)
-- 35
  • 89 (a)
ManyToMany
-- 35
  • 89 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dtd2 34 16 35
  • 79.56 (n)
rat
(Rattus norvegicus)
Mammalia Dtd2 34
  • 78.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves C14ORF126 34
  • 73.58 (n)
-- 35
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dtd2 34
  • 61.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12995 34
zebrafish
(Danio rerio)
Actinopterygii dtd2 34 35
  • 64.78 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12205 34
Species where no ortholog for DTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTD2 Gene

ENSEMBL:
Gene Tree for DTD2 (if available)
TreeFam:
Gene Tree for DTD2 (if available)

Paralogs for DTD2 Gene

Paralogs for DTD2 Gene

genes like me logo Genes that share paralogs with DTD2: view

Variants for DTD2 Gene

Sequence variations from dbSNP and Humsavar for DTD2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10136175 -- 31,445,854(+) aattg(G/T)tattc intron-variant
rs10137265 -- 31,450,188(+) TCCAC(A/G)TACCT intron-variant
rs10143393 -- 31,457,520(+) GCCCC(G/T)CCCTT upstream-variant-2KB
rs10150602 -- 31,447,189(+) ttctg(C/T)ccagg intron-variant, utr-variant-3-prime
rs111959891 -- 31,451,421(+) GGGAT(G/T)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTD2 Gene

Variant ID Type Subtype PubMed ID
nsv456198 CNV loss 19166990
nsv564179 CNV loss 21841781

Variation tolerance for DTD2 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTD2 Gene

Disorders for DTD2 Gene

Relevant External Links for DTD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTD2

No disorders were found for DTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTD2 Gene

Publications for DTD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for DTD2 Gene

Sources for DTD2 Gene

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