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Aliases for DTD1 Gene

Aliases for DTD1 Gene

  • D-Tyrosyl-TRNA Deacylase 1 2 3
  • C20orf88 3 4 6
  • DNA-Unwinding Element-Binding Protein B 3 4
  • Histidyl-TRNA Synthase-Related 3 4
  • HARS2 3 4
  • DUE-B 3 4
  • DUEB 3 4
  • D-Tyrosyl-TRNA Deacylase 1 Homolog (S. Cerevisiae) 2
  • Chromosome 20 Open Reading Frame 88 2
  • D-Tyrosyl-TRNA Deacylase 1 Homolog 3
  • D-Tyrosyl-TRNA(Tyr) Deacylase 1 3
  • Histidyl-TRNA Synthetase 2 3
  • BA555E18.1 3
  • EC 3.1.-.- 4
  • BA379J5.3 3
  • Pqn-68 3

External Ids for DTD1 Gene

Previous HGNC Symbols for DTD1 Gene

  • C20orf88
  • HARS2

Previous GeneCards Identifiers for DTD1 Gene

  • GC20P018517
  • GC20P018530

Summaries for DTD1 Gene

Entrez Gene Summary for DTD1 Gene

  • The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein is found in the cytoplasm. [provided by RefSeq, Jul 2008]

GeneCards Summary for DTD1 Gene

DTD1 (D-Tyrosyl-TRNA Deacylase 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot for DTD1 Gene

  • ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTD1 Gene

Genomics for DTD1 Gene

Regulatory Elements for DTD1 Gene

Genomic Location for DTD1 Gene

Start:
18,567,453 bp from pter
End:
18,763,917 bp from pter
Size:
196,465 bases
Orientation:
Plus strand

Genomic View for DTD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTD1 Gene

Proteins for DTD1 Gene

  • Protein details for DTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEA8-DTD1_HUMAN
    Recommended name:
    D-tyrosyl-tRNA(Tyr) deacylase 1
    Protein Accession:
    Q8TEA8
    Secondary Accessions:
    • A8K5X5
    • D3DW37
    • Q496D1
    • Q5W184
    • Q8WXU8
    • Q9BW67
    • Q9H464
    • Q9H474

    Protein attributes for DTD1 Gene

    Size:
    209 amino acids
    Molecular mass:
    23424 Da
    Quaternary structure:
    • Homodimer. Interacts with CDC45 and TOPBP1.
    SequenceCaution:
    • Sequence=BAB85044.1; Type=Miscellaneous discrepancy; Note=Presence of Alu-repeat DNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DTD1 Gene

neXtProt entry for DTD1 Gene

Proteomics data for DTD1 Gene at MOPED

Post-translational modifications for DTD1 Gene

  • Preferentially phosphorylated in cells arrested early in S phase. Phosphorylation in the C-terminus weakens the interaction with CDC45.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DTD1 Gene

Domains for DTD1 Gene

Protein Domains for DTD1 Gene

Suggested Antigen Peptide Sequences for DTD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TEA8

UniProtKB/Swiss-Prot:

DTD1_HUMAN :
  • Q8TEA8
Family:
  • Belongs to the DTD family.
genes like me logo Genes that share domains with DTD1: view

No data available for Gene Families for DTD1 Gene

Function for DTD1 Gene

Molecular function for DTD1 Gene

UniProtKB/Swiss-Prot Function: ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine.

Enzyme Numbers (IUBMB) for DTD1 Gene

Gene Ontology (GO) - Molecular Function for DTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002161 aminoacyl-tRNA editing activity IBA --
GO:0003677 DNA binding IEA --
GO:0016788 hydrolase activity, acting on ester bonds --
GO:0046872 metal ion binding IEA --
GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity IBA --
genes like me logo Genes that share ontologies with DTD1: view
genes like me logo Genes that share phenotypes with DTD1: view

miRNA for DTD1 Gene

miRTarBase miRNAs that target DTD1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DTD1 Gene

Localization for DTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTD1 Gene

Nucleus. Cytoplasm. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTD1 Gene COMPARTMENTS Subcellular localization image for DTD1 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for DTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DTD1: view

Pathways for DTD1 Gene

genes like me logo Genes that share pathways with DTD1: view

Pathways by source for DTD1 Gene

1 KEGG pathway for DTD1 Gene

Interacting Proteins for DTD1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366672%0d%0a9606.ENSP00000260810%0d%0a9606.ENSP00000217244%0d%0a9606.ENSP00000405726%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000303570%0d%0a
Selected Interacting proteins: ENSP00000366672 Q8TEA8-DTD1_HUMAN for DTD1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for DTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006399 tRNA metabolic process IBA --
GO:0006450 regulation of translational fidelity IBA --
GO:0019478 D-amino acid catabolic process IEA --
genes like me logo Genes that share ontologies with DTD1: view

Transcripts for DTD1 Gene

Unigene Clusters for DTD1 Gene

D-tyrosyl-tRNA deacylase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTD1 Gene

No ASD Table

Relevant External Links for DTD1 Gene

GeneLoc Exon Structure for
DTD1
ECgene alternative splicing isoforms for
DTD1

Expression for DTD1 Gene

mRNA expression in normal human tissues for DTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DTD1 Gene

SOURCE GeneReport for Unigene cluster for DTD1 Gene Hs.659442

mRNA Expression by UniProt/SwissProt for DTD1 Gene

Q8TEA8-DTD1_HUMAN
Tissue specificity: Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.
genes like me logo Genes that share expressions with DTD1: view

No data available for mRNA differential expression in normal tissues for DTD1 Gene

Orthologs for DTD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTD1 35
  • 99.68 (n)
  • 99.52 (a)
DTD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DTD1 35
  • 88.04 (n)
  • 94.74 (a)
DTD1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DTD1 35
  • 91.07 (n)
  • 96.65 (a)
DTD1 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtd1 35
  • 88.36 (n)
  • 95.22 (a)
Dtd1 16
Dtd1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DTD1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTD1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtd1 35
  • 87.63 (n)
  • 94.34 (a)
chicken
(Gallus gallus)
Aves DTD1 35
  • 79.77 (n)
  • 88.83 (a)
DTD1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTD1 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4690 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dtd1 35
  • 74.76 (n)
  • 82.04 (a)
Str.17396 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9158 35
zebrafish
(Danio rerio)
Actinopterygii dtd1 35
  • 71.52 (n)
  • 77.18 (a)
dtd1 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001371 35
  • 59.56 (n)
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18643 35
  • 58.96 (n)
  • 63.27 (a)
CG18643 36
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pqn-68 35
  • 54.65 (n)
  • 55.78 (a)
pqn-68 36
  • 55 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL152W 35
  • 49.65 (n)
  • 44.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DTD1 35
  • 46.94 (n)
  • 47.62 (a)
DTD1 36
  • 47 (a)
OneToOne
DTD1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08690g 35
  • 48.55 (n)
  • 41.61 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18460 35
  • 54.73 (n)
  • 53.38 (a)
rice
(Oryza sativa)
Liliopsida Os01g0242500 35
  • 58.5 (n)
  • 51.02 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03854 35
  • 50.11 (n)
  • 40.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC8C9.05 35
  • 48.59 (n)
  • 46.48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2652 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToOne
Species with no ortholog for DTD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTD1 Gene

ENSEMBL:
Gene Tree for DTD1 (if available)
TreeFam:
Gene Tree for DTD1 (if available)

Paralogs for DTD1 Gene

No data available for Paralogs for DTD1 Gene

Variants for DTD1 Gene

Sequence variations from dbSNP and Humsavar for DTD1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs9139 -- 18,763,739(+) TCCAA(C/T)ACACT utr-variant-3-prime
rs724584 -- 18,618,039(+) GACAT(A/G)ATGAA intron-variant
rs868128 -- 18,739,182(+) GGTCT(C/T)TCAAG intron-variant
rs884491 -- 18,739,026(+) GTCCT(C/T)TGCAG intron-variant
rs911010 -- 18,737,580(-) TCAGA(A/G)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTD1 Gene

Variant ID Type Subtype PubMed ID
nsv178568 CNV Loss 16902084
esv2658051 CNV Deletion 23128226
esv2468883 CNV Insertion 19546169
esv1476050 CNV Insertion 17803354
esv1401622 CNV Insertion 17803354
esv1522771 CNV Deletion 17803354
esv1653693 CNV Insertion 17803354
nsv178936 CNV Loss 16902084
esv2722264 CNV Deletion 23290073

Relevant External Links for DTD1 Gene

HapMap Linkage Disequilibrium report
DTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTD1 Gene

Disorders for DTD1 Gene

Relevant External Links for DTD1

Genetic Association Database (GAD)
DTD1
Human Genome Epidemiology (HuGE) Navigator
DTD1
genes like me logo Genes that share disorders with DTD1: view

No data available for UniProtKB/Swiss-Prot for DTD1 Gene

Publications for DTD1 Gene

  1. The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. (PMID: 20065034) Chowdhury A. … Leffak M. (Mol. Cell. Biol. 2010) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The c-myc DNA-unwinding element-binding protein modulates the assembly of DNA replication complexes in vitro. (PMID: 15653697) Casper J.M. … Leffak M. (J. Biol. Chem. 2005) 3 4

Products for DTD1 Gene

Sources for DTD1 Gene

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