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DTD1 Gene

protein-coding   GIFtS: 51
GCID: GC20P018568

D-Tyrosyl-TRNA Deacylase 1

(Previous names: chromosome 20 open reading frame 88, D-tyrosyl-tRNA deacylase...)
(Previous symbols: C20orf88, HARS2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
D-Tyrosyl-TRNA Deacylase 11 2     D-Tyrosyl-TRNA Deacylase 1 Homolog (S. Cerevisiae)1
C20orf881 2 3 5     bA379J5.32
HARS21 2 3     bA555E18.12
Histidyl-TRNA Synthase-Related2 3     D-Tyrosyl-TRNA Deacylase 1 Homolog2
DUE-B2 3     D-Tyrosyl-TRNA(Tyr) Deacylase 12
DUEB2 3     Histidyl-TRNA Synthetase 22
DNA-Unwinding Element-Binding Protein B2 3     pqn-682
Chromosome 20 Open Reading Frame 881     EC 3.1.-.-3

External Ids:    HGNC: 162191   Entrez Gene: 926752   Ensembl: ENSG000001258217   OMIM: 6109965   UniProtKB: Q8TEA83   

Export aliases for DTD1 gene to outside databases

Previous GC identifers: GC20P018517 GC20P018530


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DTD1 Gene:
The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes
D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein is found in the cytoplasm. (provided
by RefSeq, Jul 2008)

GeneCards Summary for DTD1 Gene:
DTD1 (D-tyrosyl-tRNA deacylase 1) is a protein-coding gene. GO annotations related to this gene include hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot: DTD1_HUMAN, Q8TEA8
Function: ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May
hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful
effect of D-tyrosine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DTD1 gene promoter:
         Pax-5   RelA   Gfi-1   GATA-1   FOXL1   PPAR-alpha   SRY   Cart-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDTD1 promoter sequence
   Search Chromatin IP Primers for DTD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DTD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.23   Ensembl cytogenetic band:  20p11.23   HGNC cytogenetic band: 20p11.23

DTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTD1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P018568:  view genomic region     (about GC identifiers)

Start:
18,568,537 bp from pter      End:
18,744,561 bp from pter
Size:
176,025 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DTD1_HUMAN, Q8TEA8 (See protein sequence)
Recommended Name: D-tyrosyl-tRNA(Tyr) deacylase 1  
Size: 209 amino acids; 23424 Da
Subunit: Homodimer. Interacts with CDC45 and TOPBP1
Sequence caution: Sequence=BAB85044.1; Type=Miscellaneous discrepancy; Note=Presence of Alu-repeat DNA;
1 PDB 3D structure from and Proteopedia for DTD1:
2OKV (3D)    
Secondary accessions: A8K5X5 D3DW37 Q496D1 Q5W184 Q8WXU8 Q9BW67 Q9H464 Q9H474

Explore the universe of human proteins at neXtProt for DTD1: NX_Q8TEA8

Explore proteomics data for DTD1 at MOPED

Post-translational modifications: 

  • Preferentially phosphorylated in cells arrested early in S phase. Phosphorylation in the C-terminus weakens the
    interaction with CDC451
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DTD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_543010.3  
    ENSEMBL proteins: 
     ENSP00000366672  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023509 DTD-like_dom
     IPR003732 DTyrtRNA_deacyls

    Graphical View of Domain Structure for InterPro Entry Q8TEA8

    ProtoNet protein and cluster: Q8TEA8

    1 Blocks protein domain: IPB003732 D-tyrosyl-tRNA(Tyr) deacylase

    UniProtKB/Swiss-Prot: DTD1_HUMAN, Q8TEA8
    Similarity: Belongs to the DTD family


    Find genes that share domains with DTD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DTD1_HUMAN, Q8TEA8
    Function: ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May
    hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful
    effect of D-tyrosine

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0016788hydrolase activity, acting on ester bonds IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with DTD1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DTD1:
     Decreased viability of wild-ty  Synthetic lethal with c-Myc af 

    Animal Models:
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    hsa-mir-145-5p (MIRT021511), hsa-mir-16-5p (MIRT031804)

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    4 qRT-PCR Assays for microRNAs that regulate DTD1:
    hsa-miR-140-5p hsa-miR-140-3p hsa-miR-4311 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDTD1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DTD1_HUMAN, Q8TEA8: Nucleus. Cytoplasm (Potential). Note=Associated with chromatin at some replication origins
    containing functional DNA-unwinding elements
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    mitochondrion3
    peroxisome2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005730nucleolus ----
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DTD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DTD1
    Interactions:

        Search GeneGlobe Interaction Network for DTD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for DTD1 (Q8TEA83 ENSP000003666724) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP6CO007433, ENSP000003921474I2D: score=4 STRING: ENSP00000392147
    HIRAP541983, ENSP000002632084I2D: score=1 STRING: ENSP00000263208
    NEMFO605243, ENSP000002983104I2D: score=1 STRING: ENSP00000298310
    POLR2IP369543I2D: score=5 
    ATP6V0CP274493I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0019478D-amino acid catabolic process IEA--

    Find genes that share ontologies with DTD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DTD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DTD1 gene: 
    NM_080820.4  

    Unigene Cluster for DTD1:

    D-tyrosyl-tRNA deacylase 1
    Hs.659442  [show with all ESTs]
    Unigene Representative Sequence: BM548476
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377452(uc002wrf.4) ENST00000494921
    miRNA
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    hsa-miR-140-5p hsa-miR-140-3p hsa-miR-4311 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDTD1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF332356.1 AK291440.1 BC000599.2 BC045167.2 BC100923.1 BC100924.2 BC100925.1 BC100926.1 

    10 DOTS entries:

    DT.95291367  DT.100650818  DT.40127274  DT.419076  DT.120838695  DT.120838697  DT.91759716  DT.91985228 
    DT.95291381  DT.70100622 

    Selected AceView cDNA sequences (see all 271):

    BM840899 BE278833 BM480163 BQ649919 BE047746 BE741172 AI720383 BQ926417 
    BQ062417 BM919952 AA337353 AA971718 CA421423 BE275663 AI968250 AI695872 
    BQ686626 BQ009066 CN482138 BU538348 BU157757 AA449158 BE207213 CA435579 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DTD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTTTTAT
    DTD1 Expression
    About this image


    DTD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Lens
    DTD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DTD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659442

    UniProtKB/Swiss-Prot: DTD1_HUMAN, Q8TEA8
    Tissue specificity: Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in
    adult and fetal brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DTD1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dtd11 , 5 D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)5
    D-tyrosyl-tRNA deacylase 11
    88.36(n)1
    95.22(a)1
      2 (71.02 cM)5
    660441  NM_025314.31  NP_079590.11 
     1445998975 
    chicken
    (Gallus gallus)
    Aves DTD11 D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae) 79.77(n)
    88.83(a)
      416726  NM_001199402.1  NP_001186331.1 
    lizard
    (Anolis carolinensis)
    Reptilia DTD16
    D-tyrosyl-tRNA deacylase 1
    86(a)
    1 ↔ 1
    4(79984275-80003753)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.46902 Xenopus laevis transcribed sequence with moderate similarity more 76.36(n)    AW639861.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dtd11 D-tyrosyl-tRNA deacylase 1 71.52(n)
    77.18(a)
      445046  NM_001003440.1  NP_001003440.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG186431 CG18643 58.96(n)
    63.27(a)
      41371  NM_141815.2  NP_650072.2 
    worm
    (Caenorhabditis elegans)
    Secernentea pqn-681 pqn-68 54.65(n)
    55.78(a)
      188555  NM_001047703.1  NP_001041168.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DTD1(YDL219W)4
    DTD11
    D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, more4
    DTD11
    46.94(n)1
    47.62(a)1
      4(65242-65765)4
    8513071, 4  NP_010062.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G184601 AT4G18460 54.73(n)
    53.38(a)
      827578  NM_117960.3  NP_193582.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g02425001 Os01g0242500 58.5(n)
    51.02(a)
      4327697  NM_001049091.1  NP_001042556.1 


    ENSEMBL Gene Tree for DTD1 (if available)
    TreeFam Gene Tree for DTD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DTD1 (see all 3901)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs607810911,2
    C--18526806(+) TGTGT-/GTGTGT
            
    ATAGA
    1 -- int11Minor allele frequency- GTGTGT:0.00NA 2
    rs741809151,2
    C--18539806(+) AGAAA-/GTGTGTGTGT/G
    TGTGTGTGTGTGTGT
    GTGTG
    1 -- int11NA 2
    rs61320851,2
    C,F,A--18566620(+) gtgacG/Atatag 1 -- us2k1 tfbs39Minor allele frequency- A:0.39NA WA CSA EA 370
    rs341030411,2
    C--18566957(+) TTTTTTTT/-GAGAC 2 -- us2k1 cds11Minor allele frequency- -:0.00NA 2
    rs1393511791,2
    --18567026(+) CCTCCA/GCCTCC 1 -- us2k10--------
    rs622164471,2
    C,F--18567032(+) CCTCCC/TGGGTT 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs622164481,2
    C--18567183(+) GATCCA/GCCCAC 1 -- us2k15Minor allele frequency- G:0.11NA WA CSA 9
    rs1877166451,2
    --18567206(+) AAGTGC/TTGGGA 1 -- us2k10--------
    rs1925155921,2
    --18567216(+) ATTACA/GGGTAG 1 -- us2k10--------
    rs666401421,2
    C,F--18567257(+) GGCGCG/AGTGGC 1 -- us2k15Minor allele frequency- A:0.22NA WA CSA 9

    HapMap Linkage Disequilibrium report for DTD1 (18568537 - 18744561 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DTD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658051CNV Deletion23128226
    esv2722264CNV Deletion23290073
    esv1522771CNV Deletion17803354
    esv1401622CNV Insertion17803354
    esv2468883CNV Insertion19546169
    esv1476050CNV Insertion17803354
    esv1653693CNV Insertion17803354
    nsv178568CNV Loss16902084
    nsv178936CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610996    OMIM disorders: --


    Find genes that share disorders with DTD1           About GenesLikeMe

    Genetic Association Database (GAD): DTD1
    Human Genome Epidemiology (HuGE) Navigator: DTD1 (1 document)

    Export disorders for DTD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DTD1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with DTD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. (PubMed id 20065034)1, 2 Chowdhury A....Leffak M. (Mol. Cell. Biol. 2010)
    3. The c-myc DNA-unwinding element-binding protein modulates the assembly of DNA replication complexes in vitro. (PubMed id 15653697)1, 2 Casper J.M....Leffak M. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Cloning and identification of a novel cDNA which may be associated with FKBP25. (PubMed id 12392168)1, 2 Meng X.X....Mao Y. (Biochem. Genet. 2002)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Association analysis of DTD1 gene variations with aspirin-intolerance in asthmatics. (PubMed id 21479357)1 Pasaje C.F....Shin H.D. (Int. J. Mol. Med. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92675 HGNC: 16219 AceView: HARS2 Ensembl:ENSG00000125821 euGenes: HUgn92675
    ECgene: DTD1 H-InvDB: DTD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DTD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DTD1 gene:
    Search GeneIP for patents involving DTD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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