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Aliases for DTD1 Gene

Aliases for DTD1 Gene

  • D-Tyrosyl-TRNA Deacylase 1 2 3 5
  • DNA-Unwinding Element-Binding Protein B 3 4
  • Histidyl-TRNA Synthase-Related 3 4
  • C20orf88 3 4
  • HARS2 3 4
  • DUE-B 3 4
  • DUEB 3 4
  • D-Tyrosyl-TRNA Deacylase 1 Homolog (S. Cerevisiae) 2
  • Chromosome 20 Open Reading Frame 88 2
  • D-Tyrosyl-TRNA Deacylase 1 Homolog 3
  • Histidyl-TRNA Synthetase 2 3
  • EC 3.1.-.- 4
  • Pqn-68 3

External Ids for DTD1 Gene

Previous HGNC Symbols for DTD1 Gene

  • C20orf88
  • HARS2

Previous GeneCards Identifiers for DTD1 Gene

  • GC20P018517
  • GC20P018530

Summaries for DTD1 Gene

Entrez Gene Summary for DTD1 Gene

  • The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for DTD1 Gene

DTD1 (D-Tyrosyl-TRNA Deacylase 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on ester bonds and D-tyrosyl-tRNA(Tyr) deacylase activity.

UniProtKB/Swiss-Prot for DTD1 Gene

  • ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTD1 Gene

Genomics for DTD1 Gene

Regulatory Elements for DTD1 Gene

Enhancers for DTD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DTD1 on UCSC Golden Path with GeneCards custom track

Promoters for DTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DTD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DTD1 Gene

Chromosome:
20
Start:
18,567,453 bp from pter
End:
18,763,917 bp from pter
Size:
196,465 bases
Orientation:
Plus strand

Genomic View for DTD1 Gene

Genes around DTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTD1 Gene

Proteins for DTD1 Gene

  • Protein details for DTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEA8-DTD1_HUMAN
    Recommended name:
    D-tyrosyl-tRNA(Tyr) deacylase 1
    Protein Accession:
    Q8TEA8
    Secondary Accessions:
    • A8K5X5
    • D3DW37
    • Q496D1
    • Q5W184
    • Q8WXU8
    • Q9BW67
    • Q9H464
    • Q9H474

    Protein attributes for DTD1 Gene

    Size:
    209 amino acids
    Molecular mass:
    23424 Da
    Quaternary structure:
    • Homodimer. Interacts with CDC45 and TOPBP1.
    SequenceCaution:
    • Sequence=BAB85044.1; Type=Miscellaneous discrepancy; Note=Presence of Alu-repeat DNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DTD1 Gene

neXtProt entry for DTD1 Gene

Proteomics data for DTD1 Gene at MOPED

Post-translational modifications for DTD1 Gene

  • Preferentially phosphorylated in cells arrested early in S phase. Phosphorylation in the C-terminus weakens the interaction with CDC45.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DTD1 Gene

Domains & Families for DTD1 Gene

Protein Domains for DTD1 Gene

Suggested Antigen Peptide Sequences for DTD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TEA8

UniProtKB/Swiss-Prot:

DTD1_HUMAN :
  • Belongs to the DTD family.
Family:
  • Belongs to the DTD family.
genes like me logo Genes that share domains with DTD1: view

No data available for Gene Families for DTD1 Gene

Function for DTD1 Gene

Molecular function for DTD1 Gene

UniProtKB/Swiss-Prot Function:
ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine.

Enzyme Numbers (IUBMB) for DTD1 Gene

Gene Ontology (GO) - Molecular Function for DTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002161 aminoacyl-tRNA editing activity IBA --
genes like me logo Genes that share ontologies with DTD1: view
genes like me logo Genes that share phenotypes with DTD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DTD1

miRNA for DTD1 Gene

miRTarBase miRNAs that target DTD1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTD1 Gene

Localization for DTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTD1 Gene

Nucleus. Cytoplasm. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DTD1 Gene COMPARTMENTS Subcellular localization image for DTD1 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 3
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for DTD1 Gene

Pathways & Interactions for DTD1 Gene

SuperPathways for DTD1 Gene

No Data Available

Interacting Proteins for DTD1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366672%0d%0a9606.ENSP00000260810%0d%0a9606.ENSP00000217244%0d%0a9606.ENSP00000405726%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000303570%0d%0a
Selected Interacting proteins: ENSP00000366672 Q8TEA8-DTD1_HUMAN for DTD1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for DTD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DTD1 Gene

Drugs & Compounds for DTD1 Gene

No Compound Related Data Available

Transcripts for DTD1 Gene

Unigene Clusters for DTD1 Gene

D-tyrosyl-tRNA deacylase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DTD1 Gene

No ASD Table

Relevant External Links for DTD1 Gene

GeneLoc Exon Structure for
DTD1
ECgene alternative splicing isoforms for
DTD1

Expression for DTD1 Gene

mRNA expression in normal human tissues for DTD1 Gene

Protein differential expression in normal tissues from HIPED for DTD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.6), Fetal Brain (6.6), and Frontal cortex (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DTD1 Gene



SOURCE GeneReport for Unigene cluster for DTD1 Gene Hs.659442

mRNA Expression by UniProt/SwissProt for DTD1 Gene

Q8TEA8-DTD1_HUMAN
Tissue specificity: Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.
genes like me logo Genes that share expression patterns with DTD1: view

Protein tissue co-expression partners for DTD1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for DTD1 Gene

Orthologs for DTD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DTD1 35
  • 88.04 (n)
  • 94.74 (a)
DTD1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DTD1 35
  • 91.07 (n)
  • 96.65 (a)
DTD1 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dtd1 35
  • 88.36 (n)
  • 95.22 (a)
Dtd1 16
Dtd1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DTD1 35
  • 99.68 (n)
  • 99.52 (a)
DTD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtd1 35
  • 87.63 (n)
  • 94.34 (a)
oppossum
(Monodelphis domestica)
Mammalia DTD1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTD1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTD1 35
  • 79.77 (n)
  • 88.83 (a)
DTD1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTD1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtd1 35
  • 74.76 (n)
  • 82.04 (a)
Str.17396 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4690 35
zebrafish
(Danio rerio)
Actinopterygii dtd1 35
  • 71.52 (n)
  • 77.18 (a)
dtd1 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9158 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001371 35
  • 59.56 (n)
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18643 35
  • 58.96 (n)
  • 63.27 (a)
CG18643 36
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pqn-68 35
  • 54.65 (n)
  • 55.78 (a)
pqn-68 36
  • 55 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL152W 35
  • 49.65 (n)
  • 44.76 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08690g 35
  • 48.55 (n)
  • 41.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DTD1 35
  • 46.94 (n)
  • 47.62 (a)
DTD1 36
  • 47 (a)
OneToOne
DTD1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18460 35
  • 54.73 (n)
  • 53.38 (a)
rice
(Oryza sativa)
Liliopsida Os01g0242500 35
  • 58.5 (n)
  • 51.02 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2652 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03854 35
  • 50.11 (n)
  • 40.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC8C9.05 35
  • 48.59 (n)
  • 46.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToOne
Species with no ortholog for DTD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTD1 Gene

ENSEMBL:
Gene Tree for DTD1 (if available)
TreeFam:
Gene Tree for DTD1 (if available)

Paralogs for DTD1 Gene

No data available for Paralogs for DTD1 Gene

Variants for DTD1 Gene

Sequence variations from dbSNP and Humsavar for DTD1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs9139 -- 18,763,739(+) TCCAA(C/T)ACACT utr-variant-3-prime
rs1018520 -- 18,643,854(+) GGTGT(A/G)TGTGT intron-variant
rs1018521 -- 18,666,677(+) TTGGT(A/G)TAGCT intron-variant
rs1018522 -- 18,672,384(+) CTTGG(G/T)CATGA intron-variant
rs1018523 -- 18,672,440(+) TAGCT(G/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTD1 Gene

Variant ID Type Subtype PubMed ID
nsv178568 CNV Loss 16902084
esv2658051 CNV Deletion 23128226
esv2468883 CNV Insertion 19546169
esv1476050 CNV Insertion 17803354
esv1401622 CNV Insertion 17803354
esv1522771 CNV Deletion 17803354
esv1653693 CNV Insertion 17803354
nsv178936 CNV Loss 16902084
esv2722264 CNV Deletion 23290073

Variation tolerance for DTD1 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DTD1 Gene

Disorders for DTD1 Gene

Relevant External Links for DTD1

Genetic Association Database (GAD)
DTD1
Human Genome Epidemiology (HuGE) Navigator
DTD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DTD1

No disorders were found for DTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTD1 Gene

Publications for DTD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid/lymphoid neoplasms. (PMID: 24772479) Gosenca D. … Reiter A. (Genes Chromosomes Cancer 2014) 3
  5. Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation. (PMID: 25258324) Gao Y. … Leffak M. (J. Biol. Chem. 2014) 3

Products for DTD1 Gene

Sources for DTD1 Gene

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