Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DSTYK Gene

protein-coding GIFtS: 58
GCID: GC01M205111

Dual Serine/Threonine And Tyrosine Protein Kinase

(Previous name: receptor interacting protein kinase 5)
(Previous symbol: RIPK5)

Microbiology & Infectious Diseases Congress

2 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Dual Serine/Threonine And Tyrosine Protein Kinase¹ ²		EC 2.7.12.1³ ⁸
RIPK5¹ ² ³		KIAA0472³ ⁵
RIP5² ³ ⁵		CAKUT1²
Receptor Interacting Protein Kinase 5¹ ²		DustyPK²
Dusty PK² ³		Receptor Interacting Protein 5²
Dusty Protein Kinase² ³		sgK496²
Receptor-Interacting Serine/Threonine-Protein Kinase 5² ³		SGK496³
Sugen Kinase 496² ³		SgK496³
RIP-Homologous Kinase² ³		DUSTYPK⁵

External Ids:	HGNC: 29043¹	Entrez Gene: 25778²	Ensembl: ENSG00000133059⁷	OMIM: 612666⁵	UniProtKB: Q6XUX3³

Export aliases for DSTYK gene to outside databases

Previous GC identifers: GC01M203379 GC01M176276

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DSTYK Gene:

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It

is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms

have been found for this gene. (provided by RefSeq, Dec 2008)

GeneCards Summary for DSTYK Gene:

DSTYK (dual serine/threonine and tyrosine protein kinase) is a protein-coding gene. Diseases associated with DSTYK include sarcoma, and prostatitis. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is MATK.

UniProtKB/Swiss-Prot: DUSTY_HUMAN, Q6XUX3

Function: May induce both caspase-dependent apoptosis and caspase-independent cell death

Gene Wiki entry for DSTYK (RIPK5) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.2 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DSTYK gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 p53 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DSTYK promoter sequence

Search SABiosciences Chromatin IP Primers for DSTYK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSTYK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32

DSTYK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSTYK gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M205111: view genomic region (about GC identifiers)

Start:	205,111,631 bp from pter	End:	205,180,727 bp from pter
Size:	69,097 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DUSTY_HUMAN, Q6XUX3 (See protein sequence)

Recommended Name: Dual serine/threonine and tyrosine protein kinase

Size: 929 amino acids; 105206 Da

Subcellular location: Cytoplasm

Secondary accessions: B7ZL64 O75060 Q17R94 Q5RKT0 Q6IN87 Q6P997 Q86Y03 Q9P1S5

Alternative splicing: 4 isoforms: Q6XUX3-1 Q6XUX3-2 Q6XUX3-3 Q6XUX3-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DSTYK: NX_Q6XUX3

Explore proteomics data for DSTYK at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q6XUX3

4/33 DME Specific Peptides for DSTYK (Q6XUX3) (see all 33)

YELVHTL

WKRKVAQ

AFDMQRD

ETLNTMK

DSTYK Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_056190.1 NP_955749.1

ENSEMBL proteins:

ENSP00000356129 ENSP00000356130 ENSP00000356128

Human Recombinant Protein Products for DSTYK:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for DSTYK OriGene Protein Over-expression Lysate for DSTYK OriGene MassSpec for DSTYK OriGene Custom Protein Services for DSTYK
	GenScript Custom Purified and Recombinant Proteins Services for DSTYK
	Novus Biologicals DSTYK Proteins Novus Biologicals DSTYK Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for DSTYK

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--
GO:0045111	intermediate filament cytoskeleton	IDA	--

DSTYK for ontologies About GeneDecksing

DSTYK Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for DSTYK
	GenScript Custom Superior Antibodies Services for DSTYK
	Novus Biologicals DSTYK Antibodies
	Abcam antibodies for DSTYK
	Cloud-Clone Corp. Antibodies for DSTYK
	ThermoFisher Antibodies for DSTYK
	LSBio Antibodies in human, mouse, rat for DSTYK

Assay Products for DSTYK:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for DSTYK
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DSTYK
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for DSTYK Cloud-Clone Corp. CLIAs for DSTYK

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IUPHAR Guide to PHARMACOLOGY protein family classification: dual serine/threonine and tyrosine protein kinase

Other-unique family

4 InterPro protein domains:

IPR017441 Protein_kinase_ATP_BS

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q6XUX3

ProtoNet protein and cluster: Q6XUX3

UniProtKB/Swiss-Prot: DUSTY_HUMAN, Q6XUX3

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family

Similarity: Contains 1 protein kinase domain

DSTYK for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DUSTY_HUMAN, Q6XUX3

Function: May induce both caspase-dependent apoptosis and caspase-independent cell death

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.12.1¹ ²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0004712	protein serine/threonine/tyrosine kinase activity	IEA	--
GO:0004713	protein tyrosine kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--

DSTYK for ontologies About GeneDecksing

Phenotypes:
5 GenomeRNAi human phenotypes for DSTYK:

Decreased cell number, increas	Decreased cilium length after	Decreased substrate adherent c	Increased colony dispersion (i
Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for DSTYK

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DSTYK

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DSTYK

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DSTYK

miRNA Products:		miRTarBase miRNAs that target DSTYK: hsa-mir-122 (MIRT003727)

		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DSTYK
		8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate DSTYK (see all 78):
		hsa-miR-323-3p hsa-miR-520f hsa-miR-640 hsa-miR-3152-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-200a hsa-miR-485-3p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for DSTYK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSTYK

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DSTYK
			Sirion Biotech Customized adenovirus for overexpression of DSTYK

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for DSTYK (see all 15) OriGene ORF clones in mouse, rat for DSTYK OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DSTYK (NM_015375)
		Sino Biological Human cDNA Clone for DSTYK
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSTYK
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSTYK
		Sirion Biotech Customized lentivirus for stable overexpression of DSTYK Customized lentivirus expression plasmids for stable overexpression of DSTYK

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DSTYK
		Search LifeMap BioReagents cell lines for DSTYK

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSTYK

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DSTYK

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/16 Interacting proteins for DSTYK (Q6XUX3³ ENSP00000356130⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDT	P30046³, ENSP00000215773⁴	I2D: score=2 STRING: ENSP00000215773
HSPE1	P61604³, ENSP00000233893⁴	I2D: score=2 STRING: ENSP00000233893
PSMB1	P20618³, ENSP00000262193⁴	I2D: score=2 STRING: ENSP00000262193
RAB14	P61106³, ENSP00000362946⁴	I2D: score=2 STRING: ENSP00000362946
RAB5C	P51148³, ENSP00000345689⁴	I2D: score=2 STRING: ENSP00000345689

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	--	--

DSTYK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DSTYK (DUSTY)

2 HMDB Compounds for DSTYK About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

Search CenterWatch for drugs/clinical trials and news about DSTYK / DUSTY

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DSTYK gene (2 alternative transcripts):

NM_015375.2 NM_199462.2

Unigene Cluster for DSTYK:

Dual serine/threonine and tyrosine protein kinase

Hs.6874 [show with all ESTs]

Unigene Representative Sequence: NM_015375

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367161(uc001hby.1 uc001hbx.3) ENST00000367162(uc001hbw.3)

ENST00000367160

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DSTYK
		8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate DSTYK (see all 78):
		hsa-miR-323-3p hsa-miR-520f hsa-miR-640 hsa-miR-3152-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-200a hsa-miR-485-3p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for DSTYK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSTYK

Clone Products:		OriGene clones in human, mouse for DSTYK (see all 15) OriGene ORF clones in mouse, rat for DSTYK OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DSTYK (NM_015375)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSTYK
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSTYK
		Sirion Biotech Customized lentivirus for stable overexpression of DSTYK Customized lentivirus expression plasmids for stable overexpression of DSTYK

Primer Products:		OriGene qPCR primer pairs and template standards for DSTYK OriGene qSTAR qPCR primer pairs in human, mouse for DSTYK
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DSTYK
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSTYK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSTYK

Additional mRNA sequence:

AB007941.1 AF068286.1 AJ420466.1 AK298011.1 AY208850.1 AY429674.1 BC018303.1 BC048204.1

BC053627.1 BC060870.1 BC072406.1 BC117411.1 BC143603.1

8 DOTS entries:

DT.101980615 DT.411427 DT.91746948 DT.95272142 DT.95201181 DT.411428 DT.111320 DT.75152585

24/192 AceView cDNA sequences (see all 192):

BM694016 AY208850 F04547 NM_015375 BE252310 BC053627 AI094827 AI093230

BF025947 AI948556 F02725 AI689310 AA635138 CA943816 BC072406 AI784481

BQ271688 N42371 BC018303 BU168830 BX281845 BM684173 BU170290 AA975916

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DSTYK About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b
SP1:																							-
SP2:																							-										-
SP3:
SP4:																	-		-		-		-		-		-		-				-

ECgene alternative splicing isoforms for DSTYK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DSTYK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGAGCCGAG

About this image

See DSTYK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DSTYK

SOURCE GeneReport for Unigene cluster: Hs.6874

UniProtKB/Swiss-Prot: DUSTY_HUMAN, Q6XUX3

Tissue specificity: Predominantly expressed in skeletal muscle and testis. Weakly expressed in heart, brain,

placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal

cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines

SABiosciences Custom PCR Arrays for DSTYK

Primer Products:		OriGene qPCR primer pairs and template standards for DSTYK OriGene qSTAR qPCR primer pairs in human, mouse for DSTYK
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DSTYK
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSTYK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSTYK

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSTYK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DSTYK gene from 6/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dstyk^{1 , 5}	dual serine/threonine and tyrosine protein kinase^{1, 5}	88.53(n)¹ 91.48(a)¹		1 (57.24 cM)⁵ 213452¹ NM_172516.4¹ NP_766104.2¹ 132417453⁵
chicken (Gallus gallus)	Aves	DSTYK¹	dual serine/threonine and tyrosine protein kinase	74.68(n) 79.45(a)		395171 NM_204506.2 NP_989837.1
lizard (Anolis carolinensis)	Reptilia	DSTYK⁶	dual serine/threonine and tyrosine protein kinase	78(a)	1 ↔ 1	4(116222328-116276851)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5447²	Xenopus laevis transcribed sequence with weak similarity more	77.37(n)		48043888
zebrafish (Danio rerio)	Actinopterygii	Dr.13169²	Danio rerio dusty protein kinase mRNA, complete cds	74.33(n)		AY208855.1
worm (Caenorhabditis elegans)	Secernentea	C34F11.5⁶ F23C8.7⁶ (see all 36)	Protein F23C8.7 (see all 36)	6(a) 16(a) (see all 36)	1 ↔ many 1 ↔ many (see all 36)	II(5195895-5199259) I(2422334-2425073)

ENSEMBL Gene Tree for DSTYK (if available)
TreeFam Gene Tree for DSTYK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DSTYK gene

MATK² FER² CSK² FES²

1 SIMAP similar gene for DSTYK using alignment to 2 protein entries: DUSTY_HUMAN (see all proteins):

CDK4

DSTYK for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117884285^1,2	C,F	untested¹	205160532(+)	`AGCACA/G/TAGAAT`	2	--	int¹		1		EA	120
rs3862947^1,2	C	--	176310919(-)	`TTTTT-/TTTT /TTTTTAAGAG`	2	--	int¹		1		NA	2
rs116294703^1,2		--	205111218(+)	`GCCAGC/TGTAAG`	2	--	ds500¹		0	--	--	--	--
rs141667755^1,2	C	--	205111246(+)	`CTCACA/CATGTA`	2	--	ds500¹		0	--	--	--	--
rs16855154^1,2	C,F	--	205111275(+)	`GCTCAT/CATATG`	2	--	ds500¹		12		NA WA CSA EA	512
rs191493139^1,2		--	205111313(+)	`AAAAGA/CAGCTG`	2	--	ds500¹		0	--	--	--	--
rs117727576^1,2	F	--	205111317(+)	`GAAGCT/AGGAAA`	2	--	ds500¹		1		EA	120
rs146212115^1,2		--	205111454(+)	`CAAGAA/GCCATG`	2	--	ds500¹		0	--	--	--	--
rs12749303^1,2	C,F,H	--	205111493(+)	`GGAACA/GTGTTC`	2	--	ds500¹		8		NS EA NA	544
rs7554368^1,2	C,F,H	--	205111643(-)	`GATCAC/TATTAA`	2	--	ut3¹		7		NS EA CSA WA	538

HapMap Linkage Disequilibrium report for DSTYK (205111631 - 205180727 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for DSTYK: About this table

Variant ID	Type	Subtype	PubMed ID
esv2721918	CNV	Deletion	23290073
esv2721906	CNV	Deletion	23290073
nsv468016	CNV	Loss	19166990
esv1503810	OTHER	Inversion	17803354

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DSTYK

DNA2.0 Custom Variant and Variant Library Synthesis for DSTYK

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 612666 OMIM disorders: --

2 diseases for DSTYK: About MalaCards

sarcoma prostatitis

DSTYK for disorders About GeneDecksing

Genetic Association Database (GAD): DSTYK
Human Genome Epidemiology (HuGE) Navigator: DSTYK (1 document)

Export disorders for DSTYK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DSTYK gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with DSTYK)

Utopia: connect your pdf to the dynamic
world of online information

RIP5 is a RIP-homologous inducer of cell death. (PubMed id 15178406)^{1, 2, 3} Zha J.... Shu H.B. (2004)
Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. (PubMed id 17123648)^{1, 2} Peng J....Huang C.-H. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)^{1, 2} Seki N.... Ohara O. (1997)
Mutations in DSTYK and dominant urinary tract malforma tions. (PubMed id 23862974)¹ Sanna-Cherchi S....Gharavi A.G. (2013)
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)¹ Comuzzie A.G....Butte N.F. (2012)
Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)⁴ Israni A....Oetting W.S. (2010)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)² Oppermann F.S.... Daub H. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 25778	HGNC: 29043	AceView: RIPK5	Ensembl:ENSG00000133059	euGenes: HUgn25778
ECgene: DSTYK	H-InvDB: DSTYK

(According to HUGE)
About This Section

HUGE: KIAA0472

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DSTYK	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DSTYK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DSTYK gene:
Search GeneIP for patents involving DSTYK

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for DSTYK
	OriGene qPCR primer pairs and template standards for DSTYK		OriGene Protein Over-expression Lysate for DSTYK
	OriGene MassSpec something-or-other for DSTYK		OriGene clones in human, mouse for DSTYK
	OriGene qSTAR qPCR primer pairs in human, mouse for DSTYK		OriGene Purified Protein for DSTYK
	OriGene ORF clones in mouse, rat for DSTYK		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DSTYK		OriGene Custom Protein Services for DSTYK

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DSTYK
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DSTYK
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSTYK
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSTYK
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSTYK
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSTYK

	GenScript Custom Purified and Recombinant Proteins Services for DSTYK		GenScript cDNA clones with any tag delivered in your preferred vector for DSTYK
	GenScript Custom Assay Services for DSTYK		GenScript Custom Superior Antibodies Services for DSTYK
	GenScript Custom overexpressing Cell Line Services for DSTYK		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DSTYK promoter
	Search Chromatin IP Primers for DSTYK
	RT² qPCR Primer Assay in human, mouse, rat DSTYK
	Search GNC Networks for DSTYK
	SABiosciences Custom PCR Arrays for DSTYK

Search Tocris compounds for DSTYK (DUSTY)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	cDNA Clones for DSTYK
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DSTYK antibodies
	DSTYK proteins
	DSTYK lysates

	Antibodies for DSTYK
	See all of Abcam's Antibodies, Kits and Proteins for DSTYK
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for DSTYK
	Antibodies for DSTYK
	ELISAs for DSTYK
	CLIAs for DSTYK

Search LifeMap BioReagents cell lines for DSTYK

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSTYK

	Browse SwitchGear 3'UTR luciferase reporter plasmids for DSTYK
	SwitchGear Promoter luciferase reporter plasmids for DSTYK

ThermoFisher Antibodies for DSTYK

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSTYK

	inGenious Targeting Laboratory - Custom generated mouse model solutions for DSTYK
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DSTYK

Customized:

	lentivirus for stable overexpression of DSTYK
	lentivirus expression plasmids for stable overexpression of DSTYK
	adenovirus for overexpression of DSTYK

LSBio Antibodies in human, mouse, rat for DSTYK

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DSTYK gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

DSTYK Gene

Dual Serine/Threonine And Tyrosine Protein Kinase

Aliases
for DSTYK gene

Summaries
for DSTYK gene

Genomic Views
for DSTYK gene

Proteins
for DSTYK gene

Protein Domains /
Families
for DSTYK gene

Function
for DSTYK gene

Pathways & Interactions
for DSTYK gene

Drugs & Compounds
for DSTYK gene

Transcripts
for DSTYK gene

Expression
for DSTYK gene

Orthologs
for DSTYK gene

Paralogs
for DSTYK gene

Genomic Variants
for DSTYK gene

Disorders / Diseases
for DSTYK gene

Publications
for DSTYK gene

External Searches for DSTYK gene

Genome Databases showing DSTYK gene

Other Databases showing DSTYK gene

Specialized Databases showing DSTYK gene

Intellectual Property
for DSTYK gene

Products
for DSTYK gene

View Random Gene

Advanced Search

Export list of displayed genes

DSTYK Gene

Dual Serine/Threonine And Tyrosine Protein Kinase

Aliasesfor DSTYK gene

Summariesfor DSTYK gene

Genomic Viewsfor DSTYK gene

Proteinsfor DSTYK gene

Protein Domains /Familiesfor DSTYK gene

Functionfor DSTYK gene

Pathways & Interactionsfor DSTYK gene

Drugs & Compoundsfor DSTYK gene

Transcriptsfor DSTYK gene

Expression for DSTYK gene

Orthologsfor DSTYK gene

Paralogsfor DSTYK gene

Genomic Variantsfor DSTYK gene

Disorders / Diseasesfor DSTYK gene

Publicationsfor DSTYK gene

External Searches for DSTYK gene

Genome Databases showing DSTYK gene

Other Databases showing DSTYK gene

Specialized Databases showing DSTYK gene

Intellectual Propertyfor DSTYK gene

Productsfor DSTYK gene

View Random Gene

Aliases
for DSTYK gene

Summaries
for DSTYK gene

Genomic Views
for DSTYK gene

Proteins
for DSTYK gene

Protein Domains /
Families
for DSTYK gene

Function
for DSTYK gene

Pathways & Interactions
for DSTYK gene

Drugs & Compounds
for DSTYK gene

Transcripts
for DSTYK gene

Expression
for DSTYK gene

Orthologs
for DSTYK gene

Paralogs
for DSTYK gene

Genomic Variants
for DSTYK gene

Disorders / Diseases
for DSTYK gene

Publications
for DSTYK gene

Intellectual Property
for DSTYK gene

Products
for DSTYK gene