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DSTYK Gene

protein-coding   GIFtS: 57
GCID: GC01M205111

Dual Serine/Threonine And Tyrosine Protein Kinase

(Previous name: receptor interacting protein kinase 5)
(Previous symbol: RIPK5)
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Aliases
for DSTYK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Serine/Threonine And Tyrosine Protein Kinase1 2     CAKUT12 5
RIPK51 2 3     KIAA04723 5
RIP52 3 5     Receptor Interacting Protein Kinase 51
Dusty PK2 3     DustyPK2
Dusty Protein Kinase2 3     sgK4962
Receptor-Interacting Serine/Threonine-Protein Kinase 52 3     SGK4963
Sugen Kinase 4962 3     SgK4963
RIP-Homologous Kinase2 3     DUSTYPK5
EC 2.7.12.13 8     

External Ids:    HGNC: 290431   Entrez Gene: 257782   Ensembl: ENSG000001330597   OMIM: 6126665   UniProtKB: Q6XUX33   

Export aliases for DSTYK gene to outside databases

Previous GC identifers: GC01M203379 GC01M176276


Summaries
for DSTYK gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DSTYK Gene:
This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It
is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Dec 2008)

GeneCards Summary for DSTYK Gene:
DSTYK (dual serine/threonine and tyrosine protein kinase) is a protein-coding gene. Diseases associated with DSTYK include congenital anomalies of kidney and urinary tract, and sarcoma. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is TEC.

UniProtKB/Swiss-Prot: DUSTY_HUMAN, Q6XUX3
Function: May induce both caspase-dependent apoptosis and caspase-independent cell death

Gene Wiki entry for DSTYK (RIPK5) Gene


Genomic Views
for DSTYK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DSTYK gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   p53   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DSTYK promoter sequence
   Search Chromatin IP Primers for DSTYK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DSTYK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

DSTYK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSTYK gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205111:  view genomic region     (about GC identifiers)

Start:
 205,111,631 bp from pter      End:
 205,180,727 bp from pter
Size:
 69,097 bases      Orientation:
 minus strand

Proteins
for DSTYK gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DUSTY_HUMAN, Q6XUX3 (See protein sequence)
Recommended Name: Dual serine/threonine and tyrosine protein kinase  
Size: 929 amino acids; 105206 Da
Secondary accessions: B7ZL64 O75060 Q17R94 Q5RKT0 Q6IN87 Q6P997 Q86Y03 Q9P1S5
Alternative splicing: 4 isoforms:  Q6XUX3-1   Q6XUX3-2   Q6XUX3-3   Q6XUX3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DSTYK: NX_Q6XUX3

Explore proteomics data for DSTYK at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for DSTYK (Q6XUX3) (see all 33)
     YELVHTL  WKRKVAQ  AFDMQRD  ETLNTMK 


    See DSTYK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056190.1  NP_955749.1  

    ENSEMBL proteins: 
     ENSP00000356129   ENSP00000356130   ENSP00000356128  

    DSTYK Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for DSTYK
    OriGene Custom Protein Services for DSTYK
    GenScript Custom Purified and Recombinant Proteins Services for DSTYK
    Novus Biologicals DSTYK Proteins
    Novus Biologicals DSTYK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DSTYK

    DSTYK Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for DSTYK at Abcam
    Cloud-Clone Corp. Antibodies for DSTYK
    ThermoFisher Antibodies for DSTYK
    LSBio Antibodies in human, mouse, rat for DSTYK

    DSTYK Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for DSTYK
    Cloud-Clone Corp. CLIAs for DSTYK

    Domains /
    Families
    for DSTYK gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    TryGeneCards Plus    		 IUPHAR Guide to PHARMACOLOGY protein family classification: dual serine/threonine and tyrosine protein kinase
    Other-unique family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q6XUX3

    ProtoNet protein and cluster: Q6XUX3

    UniProtKB/Swiss-Prot: DUSTY_HUMAN, Q6XUX3
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    DSTYK for domains           About GeneDecksing


    Function
    for DSTYK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUSTY_HUMAN, Q6XUX3
    Function: May induce both caspase-dependent apoptosis and caspase-independent cell death
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.12.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005524ATP binding IEA--
         
    DSTYK for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for DSTYK:
     Decreased cell number, increas  Decreased cilium length after   Decreased substrate adherent c  Increased colony dispersion (i 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DSTYK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DSTYK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DSTYK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DSTYK

    miRNA
    Products:            		miRTarBase miRNAs that target DSTYK:
    hsa-mir-148a-3p (MIRT026003), hsa-mir-93-5p (MIRT028170), hsa-mir-130b-3p (MIRT020282), hsa-mir-15a-5p (MIRT051344), hsa-mir-192-5p (MIRT026422), hsa-mir-122-5p (MIRT003727)

    Block miRNA regulation of human, mouse, rat DSTYK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DSTYK (see all 78):
    hsa-miR-323-3p hsa-miR-520f hsa-miR-640 hsa-miR-3152-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-200a hsa-miR-485-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for DSTYK
    Predesigned siRNA for gene silencing in human, mouse, rat DSTYK

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DSTYK

    Clone
    Products:             		 OriGene clones in human, mouse for DSTYK (see all 13)
    OriGene ORF clones in mouse, rat for DSTYK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DSTYK (NM_015375)
    Sino Biological Human cDNA Clone for DSTYK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSTYK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSTYK

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DSTYK
    Browse ESI BIO Cell Lines and PureStem Progenitors for DSTYK 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSTYK


    Localization
    for DSTYK gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUSTY_HUMAN, Q6XUX3: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--
    GO:0045111intermediate filament cytoskeleton ----

    DSTYK for ontologies           About GeneDecksing


    Pathways & Interactions
    for DSTYK gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DSTYK
    Interactions:

        Search GeneGlobe Interaction Network for DSTYK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for DSTYK (Q6XUX33 ENSP000003561304) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDTP300463, ENSP000002157734I2D: score=2 STRING: ENSP00000215773
    HSPE1P616043, ENSP000002338934I2D: score=2 STRING: ENSP00000233893
    PSMB1P206183, ENSP000002621934I2D: score=2 STRING: ENSP00000262193
    RAB14P611063, ENSP000003629464I2D: score=2 STRING: ENSP00000362946
    RAB5CP511483, ENSP000003456894I2D: score=2 STRING: ENSP00000345689
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    DSTYK for ontologies           About GeneDecksing



    Drugs & Compounds
    for DSTYK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DSTYK (DUSTY)

    2 HMDB Compounds for DSTYK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    Transcripts
    for DSTYK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DSTYK gene (2 alternative transcripts): 
    NM_015375.2  NM_199462.2  

    Unigene Cluster for DSTYK:

    Dual serine/threonine and tyrosine protein kinase
    Hs.6874  [show with all ESTs]
    Unigene Representative Sequence: NM_015375
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367161(uc001hby.1 uc001hbx.3) ENST00000367162(uc001hbw.3)
    ENST00000367160
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat DSTYK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DSTYK (see all 78):
    hsa-miR-323-3p hsa-miR-520f hsa-miR-640 hsa-miR-3152-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-200a hsa-miR-485-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for DSTYK
    Predesigned siRNA for gene silencing in human, mouse, rat DSTYK
    Clone
    Products:             		 OriGene clones in human, mouse for DSTYK (see all 13)
    OriGene ORF clones in mouse, rat for DSTYK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DSTYK (NM_015375)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSTYK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSTYK
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for DSTYK
    OriGene qSTAR qPCR primer pairs in human, mouse for DSTYK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DSTYK
      QuantiTect SYBR Green Assays in human, mouse, rat DSTYK
      QuantiFast Probe-based Assays in human, mouse, rat DSTYK

    Additional mRNA sequence: 

    AB007941.1 AF068286.1 AJ420466.1 AK298011.1 AY208850.1 AY429674.1 BC018303.1 BC048204.1 
    BC053627.1 BC060870.1 BC072406.1 BC117411.1 BC143603.1 

    8 DOTS entries:

    DT.101980615  DT.411427  DT.91746948  DT.95272142  DT.95201181  DT.411428  DT.111320  DT.75152585 

    Selected AceView cDNA sequences (see all 192):

    BQ230886 AA256604 AI094827 BU170290 AI241536 AA635138 BU168830 CD655678 
    BU161834 CA390466 BG575815 AI784481 BX283937 BC053627 Z41812 BM726080 
    NM_199462 BU634175 BC072406 BM083921 N42371 BC018303 AA975916 BU159766 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DSTYK    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                                                                    -                                             
    SP2:                                                                    -                             -               
    SP3:                                                                                                                  
    SP4:                                                  -     -     -     -     -     -     -           -               


    ECgene alternative splicing isoforms for DSTYK

    Expression
    for DSTYK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DSTYK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAGCCGAG
    DSTYK Expression
    About this image

    DSTYK Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    DSTYK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6874

    UniProtKB/Swiss-Prot: DUSTY_HUMAN, Q6XUX3
    Tissue specificity: Predominantly expressed in skeletal muscle and testis. Weakly expressed in heart, brain,
    placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal
    cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines

        Custom PCR Arrays for DSTYK
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DSTYK
    QuantiTect SYBR Green Assays in human, mouse, rat DSTYK
    QuantiFast Probe-based Assays in human, mouse, rat DSTYK
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSTYK

    Orthologs
    for DSTYK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DSTYK gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dstyk1 , 5 dual serine/threonine and tyrosine protein kinase1, 5 88.53(n)1
    91.48(a)1    		   1 (57.24 cM)5
    2134521  NM_172516.41  NP_766104.21 
     1324174535 
    chicken
    (Gallus gallus)    		 Aves DSTYK1 dual serine/threonine and tyrosine protein kinase 74.68(n)
    79.45(a)    		   395171  NM_204506.2  NP_989837.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DSTYK6
    		 dual serine/threonine and tyrosine protein kinase
    		 78(a)
    		 1 ↔ 1
    		 4(116222328-116276851)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.54472 Xenopus laevis transcribed sequence with weak similarity more 77.37(n)    48043888 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.131692 Danio rerio dusty protein kinase mRNA, complete cds 74.33(n)    AY208855.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta png6
    Wsck6
    		 Wsck
    		 20(a)
    15(a)
    		 many ↔ many
    many ↔ many
    		 X(1250521-1251646)
    3R(20452796-20455810)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y47G6A.56
    		 Protein Y47G6A.5, isoform a
    		 13(a)
    		 many ↔ many
    		 I(3533994-3539156) WBGene00021635
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CDC156
    		 Protein kinase of the Mitotic Exit Network that is...
    		 10(a)
    		 1 → many
    		 I(172211-175135) YAR019C


    ENSEMBL Gene Tree for DSTYK (if available)
    TreeFam Gene Tree for DSTYK (if available)

    Paralogs
    for DSTYK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DSTYK gene
    TEC2  CSK2  FER2  ITK2  TXK2  FES2  MATK2  BMX2  
    BTK2  
    1 SIMAP similar gene for DSTYK using alignment to 2 protein entries:     DUSTY_HUMAN (see all proteins):
    CDK4

    DSTYK for paralogs           About GeneDecksing



    Genomic Variants
    for DSTYK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DSTYK (see all 1408)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1178842851,2
    		C,Funtested1205160532(+) AGCACA/G/TAGAAT 2 -- int11EA 120
    rs38629471,2
    		C--176310919(-) TTTTT-/TTTT  
          /TTTTT    AAGAG     		2 -- int11NA 2
    rs1162947031,2
    		--205111218(+) GCCAGC/TGTAAG 2 -- ds50010--------
    rs1416677551,2
    		C--205111246(+) CTCACA/CATGTA 2 -- ds50010--------
    rs168551541,2
    		C,F--205111275(+) GCTCAT/CATATG 2 -- ds500112Minor allele frequency- C:0.32NA WA CSA EA 512
    rs1914931391,2
    		--205111313(+) AAAAGA/CAGCTG 2 -- ds50010--------
    rs1177275761,2
    		F--205111317(+) GAAGCT/AGGAAA 2 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1462121151,2
    		--205111454(+) CAAGAA/GCCATG 2 -- ds50010--------
    rs127493031,2
    		C,F,H--205111493(+) GGAACA/GTGTTC 2 -- ds50018Minor allele frequency- G:0.03NS EA NA 544
    rs75543681,2
    		C,F,H--205111643(-) GATCAC/TATTAA 2 -- ut317Minor allele frequency- T:0.02NS EA CSA WA 538

    HapMap Linkage Disequilibrium report for DSTYK (205111631 - 205180727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DSTYK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721918CNV Deletion23290073
    esv2721906CNV Deletion23290073
    nsv468016CNV Loss19166990
    esv1503810OTHER Inversion17803354

    Human Gene Mutation Database (HGMD): DSTYK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DSTYK
    DNA2.0 Custom Variant and Variant Library Synthesis for DSTYK

    Disorders / Diseases
    for DSTYK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 612666   
    OMIM disorders: 610805  
    4 diseases for DSTYK:    About MalaCards
    congenital anomalies of kidney and urinary tract    sarcoma    obesity    prostatitis


    DSTYK for disorders           About GeneDecksing

    Genetic Association Database (GAD): DSTYK
    Human Genome Epidemiology (HuGE) Navigator: DSTYK (1 document)

    Export disorders for DSTYK gene to outside databases

    Publications
    for DSTYK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for DSTYK gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with DSTYK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RIP5 is a RIP-homologous inducer of cell death. (PubMed id 15178406)1, 2, 3 Zha J.... Shu H.B. (Biochem. Biophys. Res. Commun. 2004)
    2. Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. (PubMed id 17123648)1, 2 Peng J....Huang C.-H. (Biochim. Biophys. Acta 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (DNA Res. 1997)
    5. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PubMed id 24026423)1 Shameer K....Kullo I.J. (Hum. Genet. 2014)
    6. Mutations in DSTYK and dominant urinary tract malformations. (PubMed id 23862974)1 Sanna-Cherchi S....Gharavi A.G. (N. Engl. J. Med. 2013)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    10. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (Mol. Cell. Proteomics 2009)

    External Searches for DSTYK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing DSTYK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25778 HGNC: 29043 AceView: RIPK5 Ensembl:ENSG00000133059 euGenes: HUgn25778
    ECgene: DSTYK H-InvDB: DSTYK

    Other Databases showing DSTYK gene

    (According to HUGE)
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    HUGE: KIAA0472

    Specialized Databases showing DSTYK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DSTYK Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DSTYK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for DSTYK gene:
    Search GeneIP for patents involving DSTYK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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