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Aliases for DSTYK Gene

Aliases for DSTYK Gene

  • Dual Serine/Threonine And Tyrosine Protein Kinase 2 3 5
  • Receptor-Interacting Serine/Threonine-Protein Kinase 5 3 4
  • RIP-Homologous Kinase 3 4
  • Dusty Protein Kinase 3 4
  • Sugen Kinase 496 3 4
  • EC 2.7.12.1 4 63
  • Dusty PK 3 4
  • SgK496 3 4
  • RIPK5 3 4
  • RIP5 3 4
  • Receptor Interacting Protein Kinase 5 2
  • HDCMD38P 3
  • KIAA0472 4
  • DustyPK 3
  • CAKUT1 3

External Ids for DSTYK Gene

Previous HGNC Symbols for DSTYK Gene

  • RIPK5

Previous GeneCards Identifiers for DSTYK Gene

  • GC01M203379
  • GC01M176276

Summaries for DSTYK Gene

Entrez Gene Summary for DSTYK Gene

  • This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for DSTYK Gene

DSTYK (Dual Serine/Threonine And Tyrosine Protein Kinase) is a Protein Coding gene. Diseases associated with DSTYK include congenital anomalies of kidney and urinary tract and renal agenesis, unilateral. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for DSTYK Gene

  • Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.

Gene Wiki entry for DSTYK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSTYK Gene

Genomics for DSTYK Gene

Regulatory Elements for DSTYK Gene

Enhancers for DSTYK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DSTYK on UCSC Golden Path with GeneCards custom track

Promoters for DSTYK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DSTYK on UCSC Golden Path with GeneCards custom track

Genomic Location for DSTYK Gene

Chromosome:
1
Start:
205,142,503 bp from pter
End:
205,211,599 bp from pter
Size:
69,097 bases
Orientation:
Minus strand

Genomic View for DSTYK Gene

Genes around DSTYK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DSTYK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DSTYK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSTYK Gene

Proteins for DSTYK Gene

  • Protein details for DSTYK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XUX3-DUSTY_HUMAN
    Recommended name:
    Dual serine/threonine and tyrosine protein kinase
    Protein Accession:
    Q6XUX3
    Secondary Accessions:
    • B7ZL64
    • O75060
    • Q17R94
    • Q5RKT0
    • Q6IN87
    • Q6P997
    • Q86Y03
    • Q9P1S5

    Protein attributes for DSTYK Gene

    Size:
    929 amino acids
    Molecular mass:
    105206 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DSTYK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DSTYK Gene

Proteomics data for DSTYK Gene at MOPED

Post-translational modifications for DSTYK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DSTYK Gene

Domains & Families for DSTYK Gene

Gene Families for DSTYK Gene

Suggested Antigen Peptide Sequences for DSTYK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6XUX3

UniProtKB/Swiss-Prot:

DUSTY_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with DSTYK: view

Function for DSTYK Gene

Molecular function for DSTYK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.

Enzyme Numbers (IUBMB) for DSTYK Gene

genes like me logo Genes that share phenotypes with DSTYK: view

Human Phenotype Ontology for DSTYK Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for DSTYK

CRISPR Products

miRNA for DSTYK Gene

miRTarBase miRNAs that target DSTYK

No data available for Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DSTYK Gene

Localization for DSTYK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DSTYK Gene

Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction. Note=Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. {ECO:0000250 UniProtKB:Q6XUX1, ECO:0000269 PubMed:23862974}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DSTYK Gene COMPARTMENTS Subcellular localization image for DSTYK gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for DSTYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016324 apical plasma membrane IDA 23862974
genes like me logo Genes that share ontologies with DSTYK: view

Pathways & Interactions for DSTYK Gene

SuperPathways for DSTYK Gene

No Data Available

Gene Ontology (GO) - Biological Process for DSTYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033674 positive regulation of kinase activity IMP 23862974
GO:0044344 cellular response to fibroblast growth factor stimulus IDA 23862974
genes like me logo Genes that share ontologies with DSTYK: view

No data available for Pathways by source and SIGNOR curated interactions for DSTYK Gene

Drugs & Compounds for DSTYK Gene

(1) Drugs for DSTYK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DSTYK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DSTYK: view

Transcripts for DSTYK Gene

Unigene Clusters for DSTYK Gene

Dual serine/threonine and tyrosine protein kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DSTYK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - -
SP3:
SP4: - - - - - - - -

Relevant External Links for DSTYK Gene

GeneLoc Exon Structure for
DSTYK
ECgene alternative splicing isoforms for
DSTYK

Expression for DSTYK Gene

mRNA expression in normal human tissues for DSTYK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DSTYK Gene

This gene is overexpressed in Adrenal (30.2) and Adipocyte (26.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DSTYK Gene



SOURCE GeneReport for Unigene cluster for DSTYK Gene Hs.6874

mRNA Expression by UniProt/SwissProt for DSTYK Gene

Q6XUX3-DUSTY_HUMAN
Tissue specificity: Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines.
genes like me logo Genes that share expression patterns with DSTYK: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DSTYK Gene

Orthologs for DSTYK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DSTYK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DSTYK 35
  • 91.56 (n)
  • 93.86 (a)
DSTYK 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DSTYK 35
  • 90.56 (n)
  • 94.08 (a)
DSTYK 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dstyk 35
  • 88.53 (n)
  • 91.48 (a)
Dstyk 16
Dstyk 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DSTYK 35
  • 99.78 (n)
  • 99.46 (a)
DSTYK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dstyk 35
  • 88.03 (n)
  • 91.15 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves DSTYK 35
  • 74.68 (n)
  • 79.45 (a)
DSTYK 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DSTYK 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dstyk 35
  • 68.99 (n)
  • 73.87 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5447 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13169 35
dstyk 35
  • 67.19 (n)
  • 71.17 (a)
dstyk 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta png 36
  • 20 (a)
ManyToMany
Wsck 36
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y47G6A.5 36
  • 13 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 36
  • 10 (a)
OneToMany
Species with no ortholog for DSTYK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DSTYK Gene

ENSEMBL:
Gene Tree for DSTYK (if available)
TreeFam:
Gene Tree for DSTYK (if available)

Paralogs for DSTYK Gene

(1) SIMAP similar genes for DSTYK Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DSTYK: view

No data available for Paralogs for DSTYK Gene

Variants for DSTYK Gene

Sequence variations from dbSNP and Humsavar for DSTYK Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35845538 - 205,169,193(+) ATCCA(C/G)AAGTT reference, missense
VAR_071324 Congenital anomalies of the kidney and urinary tract 1 (CAKUT1)
VAR_071325 Congenital anomalies of the kidney and urinary tract 1 (CAKUT1)
VAR_071326 Congenital anomalies of the kidney and urinary tract 1 (CAKUT1)
rs2836 -- 205,142,633(+) GTCGC(A/C)TCTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DSTYK Gene

Variant ID Type Subtype PubMed ID
nsv468016 CNV Loss 19166990
esv2721906 CNV Deletion 23290073
esv2721918 CNV Deletion 23290073
esv1503810 OTHER Inversion 17803354

Variation tolerance for DSTYK Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DSTYK Gene

HapMap Linkage Disequilibrium report
DSTYK
Human Gene Mutation Database (HGMD)
DSTYK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSTYK Gene

Disorders for DSTYK Gene

MalaCards: The human disease database

(3) MalaCards diseases for DSTYK Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
congenital anomalies of kidney and urinary tract
  • renal hypodysplasia, nonsyndromic, 1
renal agenesis, unilateral
posterior urethral valves
  • posterior urethral valve
- elite association - COSMIC cancer census association via MalaCards
Search DSTYK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DUSTY_HUMAN
  • Congenital anomalies of the kidney and urinary tract 1 (CAKUT1) [MIM:610805]: A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children. {ECO:0000269 PubMed:23862974}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for DSTYK

Genetic Association Database (GAD)
DSTYK
Human Genome Epidemiology (HuGE) Navigator
DSTYK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DSTYK
genes like me logo Genes that share disorders with DSTYK: view

No data available for Genatlas for DSTYK Gene

Publications for DSTYK Gene

  1. RIP5 is a RIP-homologous inducer of cell death. (PMID: 15178406) Zha J. … Shu H.B. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PMID: 24026423) Shameer K. … Kullo I.J. (Hum. Genet. 2014) 3
  5. Mutations in DSTYK and dominant urinary tract malformations. (PMID: 23862974) Sanna-Cherchi S. … Gharavi A.G. (N. Engl. J. Med. 2013) 3

Products for DSTYK Gene

Sources for DSTYK Gene

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