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Aliases for DSTYK Gene

Aliases for DSTYK Gene

  • Dual Serine/Threonine And Tyrosine Protein Kinase 2 3
  • RIP5 3 4 6
  • Receptor-Interacting Serine/Threonine-Protein Kinase 5 3 4
  • RIP-Homologous Kinase 3 4
  • Dusty Protein Kinase 3 4
  • Sugen Kinase 496 3 4
  • EC 4 63
  • Dusty PK 3 4
  • KIAA0472 4 6
  • DustyPK 3 6
  • SgK496 3 4
  • CAKUT1 3 6
  • RIPK5 3 4
  • Receptor Interacting Protein Kinase 5 2
  • HDCMD38P 3

External Ids for DSTYK Gene

Previous HGNC Symbols for DSTYK Gene

  • RIPK5

Previous GeneCards Identifiers for DSTYK Gene

  • GC01M203379
  • GC01M176276

Summaries for DSTYK Gene

Entrez Gene Summary for DSTYK Gene

  • This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for DSTYK Gene

DSTYK (Dual Serine/Threonine And Tyrosine Protein Kinase) is a Protein Coding gene. Diseases associated with DSTYK include congenital anomalies of kidney and urinary tract and unilateral renal agenesis. GO annotations related to this gene include protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. An important paralog of this gene is FER.

UniProtKB/Swiss-Prot for DSTYK Gene

  • Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.

Gene Wiki entry for DSTYK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSTYK Gene

Genomics for DSTYK Gene

Regulatory Elements for DSTYK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DSTYK Gene

205,142,503 bp from pter
205,211,599 bp from pter
69,097 bases
Minus strand

Genomic View for DSTYK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DSTYK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSTYK Gene

Proteins for DSTYK Gene

  • Protein details for DSTYK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual serine/threonine and tyrosine protein kinase
    Protein Accession:
    Secondary Accessions:
    • B7ZL64
    • O75060
    • Q17R94
    • Q5RKT0
    • Q6IN87
    • Q6P997
    • Q86Y03
    • Q9P1S5

    Protein attributes for DSTYK Gene

    929 amino acids
    Molecular mass:
    105206 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DSTYK Gene


neXtProt entry for DSTYK Gene

Proteomics data for DSTYK Gene at MOPED

Post-translational modifications for DSTYK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DSTYK Gene

Domains for DSTYK Gene

Protein Domains for DSTYK Gene

Suggested Antigen Peptide Sequences for DSTYK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6XUX3
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with DSTYK: view

Function for DSTYK Gene

Molecular function for DSTYK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.

Enzyme Numbers (IUBMB) for DSTYK Gene

Gene Ontology (GO) - Molecular Function for DSTYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DSTYK: view
genes like me logo Genes that share phenotypes with DSTYK: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DSTYK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DSTYK Gene

Localization for DSTYK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DSTYK Gene

Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction. Note=Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. {ECO:0000250 UniProtKB:Q6XUX1, ECO:0000269 PubMed:23862974}.

Subcellular locations from

Jensen Localization Image for DSTYK Gene COMPARTMENTS Subcellular localization image for DSTYK gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DSTYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23862974
GO:0016323 basolateral plasma membrane IDA 23862974
GO:0016324 apical plasma membrane IDA 23862974
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DSTYK: view

Pathways for DSTYK Gene

SuperPathways for DSTYK Gene

No Data Available

Gene Ontology (GO) - Biological Process for DSTYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0033674 positive regulation of kinase activity IMP 23862974
GO:0044344 cellular response to fibroblast growth factor stimulus IDA 23862974
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway IMP 23862974
genes like me logo Genes that share ontologies with DSTYK: view

No data available for Pathways by source for DSTYK Gene

Compounds for DSTYK Gene

(2) HMDB Compounds for DSTYK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
genes like me logo Genes that share compounds with DSTYK: view

Transcripts for DSTYK Gene

Unigene Clusters for DSTYK Gene

Dual serine/threonine and tyrosine protein kinase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DSTYK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DSTYK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - -
SP4: - - - - - - - -

Relevant External Links for DSTYK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DSTYK Gene

mRNA expression in normal human tissues for DSTYK Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DSTYK Gene

SOURCE GeneReport for Unigene cluster for DSTYK Gene Hs.6874

mRNA Expression by UniProt/SwissProt for DSTYK Gene

Tissue specificity: Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines.
genes like me logo Genes that share expressions with DSTYK: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DSTYK Gene

Orthologs for DSTYK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DSTYK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DSTYK 35
  • 99.78 (n)
  • 99.46 (a)
  • 99 (a)
(Bos Taurus)
Mammalia DSTYK 35
  • 91.56 (n)
  • 93.86 (a)
  • 94 (a)
(Canis familiaris)
Mammalia DSTYK 35
  • 90.56 (n)
  • 94.08 (a)
  • 97 (a)
(Mus musculus)
Mammalia Dstyk 35
  • 88.53 (n)
  • 91.48 (a)
Dstyk 16
Dstyk 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
-- 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Dstyk 35
  • 88.03 (n)
  • 91.15 (a)
(Gallus gallus)
Aves DSTYK 35
  • 74.68 (n)
  • 79.45 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia DSTYK 36
  • 78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5447 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dstyk 35
  • 68.99 (n)
  • 73.87 (a)
(Danio rerio)
Actinopterygii Dr.13169 35
dstyk 35
  • 67.19 (n)
  • 71.17 (a)
dstyk 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta png 36
  • 20 (a)
Wsck 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea Y47G6A.5 36
  • 13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 36
  • 10 (a)
Species with no ortholog for DSTYK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DSTYK Gene

Gene Tree for DSTYK (if available)
Gene Tree for DSTYK (if available)

Paralogs for DSTYK Gene

Paralogs for DSTYK Gene

Selected SIMAP similar genes for DSTYK Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DSTYK: view

Variants for DSTYK Gene

Sequence variations from dbSNP and Humsavar for DSTYK Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2836 -- 205,142,633(+) GTCGC(A/C)TCTCT utr-variant-3-prime
rs11367 -- 205,147,507(-) TCACC(A/T)TTTGG utr-variant-3-prime
rs1046925 -- 205,142,658(-) ACCGT(C/T)TTAAT utr-variant-3-prime
rs1061132 -- 205,146,022(-) GTCTG(G/T)GAAGT utr-variant-3-prime
rs1062715 -- 205,160,191(-) CACTT(C/T)CCTTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DSTYK Gene

Variant ID Type Subtype PubMed ID
nsv468016 CNV Loss 19166990
esv2721906 CNV Deletion 23290073
esv2721918 CNV Deletion 23290073
esv1503810 OTHER Inversion 17803354

Relevant External Links for DSTYK Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSTYK Gene

Disorders for DSTYK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for DSTYK Gene including...

Search for DSTYK Gene in MalaCards »

(1) OMIM Diseases for DSTYK Gene (612666)


  • Congenital anomalies of the kidney and urinary tract (CAKUT) [MIM:610805]: A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. CAKUT is the commonest cause of chronic kidney disease in children. {ECO:0000269 PubMed:23862974}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for DSTYK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DSTYK: view

Publications for DSTYK Gene

  1. RIP5 is a RIP-homologous inducer of cell death. (PMID: 15178406) Zha J. … Shu H.B. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mutations in DSTYK and dominant urinary tract malformations. (PMID: 23862974) Sanna-Cherchi S. … Gharavi A.G. (N. Engl. J. Med. 2013) 3 4
  4. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4
  5. Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. (PMID: 17123648) Peng J. … Huang C.-H. (Biochim. Biophys. Acta 2006) 3 4

Products for DSTYK Gene

  • Addgene plasmids for DSTYK

Sources for DSTYK Gene

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