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Aliases for DSTN Gene

Aliases for DSTN Gene

  • Destrin (Actin Depolymerizing Factor) 2 3
  • Actin-Depolymerizing Factor 3 4
  • ACTDP 3 4
  • ADF 3 4
  • BA462D18.2 (Destrin (Actin Depolymerizing Factor ADF) (ACTDP)) 3
  • Epididymis Luminal Protein 32 3
  • BA462D18.2 3
  • HEL32 3
  • DSN 4

External Ids for DSTN Gene

Previous GeneCards Identifiers for DSTN Gene

  • GC20P017539
  • GC20P017545
  • GC20P017498

Summaries for DSTN Gene

Entrez Gene Summary for DSTN Gene

  • The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DSTN Gene

DSTN (Destrin (Actin Depolymerizing Factor)) is a Protein Coding gene. Diseases associated with DSTN include necatoriasis. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Development Slit-Robo signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is CFL2.

UniProtKB/Swiss-Prot for DSTN Gene

  • Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSTN Gene

Genomics for DSTN Gene

Regulatory Elements for DSTN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DSTN Gene

Chromosome:
20
Start:
17,569,173 bp from pter
End:
17,609,919 bp from pter
Size:
40,747 bases
Orientation:
Plus strand

Genomic View for DSTN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DSTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSTN Gene

Proteins for DSTN Gene

  • Protein details for DSTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60981-DEST_HUMAN
    Recommended name:
    Destrin
    Protein Accession:
    P60981
    Secondary Accessions:
    • B2R6N2
    • B4DYA6
    • P18282
    • Q5W166
    • Q6IAW2

    Protein attributes for DSTN Gene

    Size:
    165 amino acids
    Molecular mass:
    18506 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DSTN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DSTN Gene

Proteomics data for DSTN Gene at MOPED

Post-translational modifications for DSTN Gene

Other Protein References for DSTN Gene

Antibody Products

No data available for DME Specific Peptides for DSTN Gene

Domains & Families for DSTN Gene

Protein Domains for DSTN Gene

Suggested Antigen Peptide Sequences for DSTN Gene

Graphical View of Domain Structure for InterPro Entry

P60981

UniProtKB/Swiss-Prot:

DEST_HUMAN :
  • Contains 1 ADF-H domain.
  • Belongs to the actin-binding proteins ADF family.
Domain:
  • Contains 1 ADF-H domain.
Family:
  • Belongs to the actin-binding proteins ADF family.
genes like me logo Genes that share domains with DSTN: view

No data available for Gene Families for DSTN Gene

Function for DSTN Gene

Molecular function for DSTN Gene

UniProtKB/Swiss-Prot Function:
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner

Gene Ontology (GO) - Molecular Function for DSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DSTN: view
genes like me logo Genes that share phenotypes with DSTN: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DSTN Gene

Localization for DSTN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DSTN Gene COMPARTMENTS Subcellular localization image for DSTN gene
Compartment Confidence
extracellular 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for DSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0015629 actin cytoskeleton TAS 8399167
GO:0030864 cortical actin cytoskeleton IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DSTN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DSTN Gene

Pathways & Interactions for DSTN Gene

genes like me logo Genes that share pathways with DSTN: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008154 actin polymerization or depolymerization TAS 8399167
GO:0030042 actin filament depolymerization IEA --
GO:0030836 positive regulation of actin filament depolymerization IEA --
GO:0051014 actin filament severing IEA --
genes like me logo Genes that share ontologies with DSTN: view

No data available for SIGNOR curated interactions for DSTN Gene

Drugs & Compounds for DSTN Gene

(5) Drugs for DSTN Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lauryl Dimethylamine-N-Oxide Experimental Pharma Target 0
ATP Pharma Activator 0
Calcium Nutra 0
serine Nutra 420
threonine Nutra 16

(3) Additional Compounds for DSTN Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
DMSO
Isocitrate
Phalloidin
genes like me logo Genes that share compounds with DSTN: view

Transcripts for DSTN Gene

Unigene Clusters for DSTN Gene

Destrin (actin depolymerizing factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DSTN Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5:
SP6: - -

Relevant External Links for DSTN Gene

GeneLoc Exon Structure for
DSTN
ECgene alternative splicing isoforms for
DSTN

Expression for DSTN Gene

mRNA expression in normal human tissues for DSTN Gene

mRNA differential expression in normal tissues according to GTEx for DSTN Gene

This gene is overexpressed in Artery - Tibial (x6.4).

Protein differential expression in normal tissues from HIPED for DSTN Gene

This gene is overexpressed in Colon muscle (10.2) and Cardia (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DSTN Gene



SOURCE GeneReport for Unigene cluster for DSTN Gene Hs.304192

mRNA Expression by UniProt/SwissProt for DSTN Gene

P60981-DEST_HUMAN
Tissue specificity: Widely distributed in various tissues
genes like me logo Genes that share expression patterns with DSTN: view

Protein tissue co-expression partners for DSTN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DSTN Gene

Orthologs for DSTN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DSTN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DSTN 35
  • 93.13 (n)
  • 100 (a)
DSTN 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DSTN 35
  • 96.4 (n)
  • 100 (a)
DSTN 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dstn 35
  • 90.71 (n)
  • 95.76 (a)
Dstn 16
Dstn 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DSTN 35
  • 100 (n)
  • 100 (a)
DSTN 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DSTN 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
chicken
(Gallus gallus)
Aves DSTN 35
  • 84.44 (n)
  • 95.15 (a)
DSTN 36
  • 95 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cfl1l 36
  • 47 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COF1 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
CSA.4636 36
  • 28 (a)
ManyToMany
Species with no ortholog for DSTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DSTN Gene

ENSEMBL:
Gene Tree for DSTN (if available)
TreeFam:
Gene Tree for DSTN (if available)

Paralogs for DSTN Gene

Paralogs for DSTN Gene

(2) SIMAP similar genes for DSTN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DSTN: view

Variants for DSTN Gene

Sequence variations from dbSNP and Humsavar for DSTN Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1051084 -- 17,607,356(+) TGGCC(A/C)AATGC utr-variant-3-prime
rs1051234 -- 17,608,160(+) CACTT(C/T)GAACG downstream-variant-500B, utr-variant-3-prime
rs1051235 -- 17,600,859(+) CAGTG(C/T)AGACA reference, missense
rs1051238 -- 17,608,243(+) ACTTA(C/T)CTCTC downstream-variant-500B
rs1407195 -- 17,571,704(+) ATTAT(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DSTN Gene

Variant ID Type Subtype PubMed ID
nsv510781 CNV Loss 20534489
nsv520496 CNV Gain 19592680
dgv4556n71 CNV Loss 21882294
nsv3311 CNV Insertion 18451855

Variation tolerance for DSTN Gene

Residual Variation Intolerance Score: 38.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DSTN Gene

HapMap Linkage Disequilibrium report
DSTN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSTN Gene

Disorders for DSTN Gene

MalaCards: The human disease database

(1) MalaCards diseases for DSTN Gene - From: DISEASES

Disorder Aliases PubMed IDs
necatoriasis
- elite association
Search DSTN in MalaCards View complete list of genes associated with diseases

Relevant External Links for DSTN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DSTN
genes like me logo Genes that share disorders with DSTN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DSTN Gene

Publications for DSTN Gene

  1. Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. (PMID: 8399167) Hawkins M. … Weeds A.G. (Biochemistry 1993) 2 23 67
  2. ADF/cofilin: a functional node in cell biology. (PMID: 20133134) Bernstein B.W. … Bamburg J.R. (Trends Cell Biol. 2010) 23 67
  3. Actin filament remodeling by actin depolymerization factor/cofilin. (PMID: 20368459) Pfaendtner J. … Voth G.A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67
  4. ADF/cofilin binds phosphoinositides in a multivalent manner to act as a PIP(2)-density sensor. (PMID: 20483342) Zhao H. … Lappalainen P. (Biophys. J. 2010) 23 67
  5. Isolation and characterization of cytoplasmic cofilin-actin rods. (PMID: 20022956) Minamide L.S. … Bamburg J.R. (J. Biol. Chem. 2010) 23 67

Products for DSTN Gene

Sources for DSTN Gene

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