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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DSTN Gene

protein-coding   GIFtS: 60
GCID: GC20P017550

Destrin (Actin Depolymerizing Factor)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Destrin (Actin Depolymerizing Factor)1 2     bA462D18.22
ADF2 3 5     BA462D18.2 (Destrin (Actin Depolymerizing Factor ADF) (ACTDP))2
Actin-Depolymerizing Factor2 3     destrin2
ACTDP2 3     DSN3

External Ids:    HGNC: 157501   Entrez Gene: 110342   Ensembl: ENSG000001258687   OMIM: 6091145   UniProtKB: P609813   

Export aliases for DSTN gene to outside databases

Previous GC identifers: GC20P017539 GC20P017545 GC20P017498


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DSTN Gene:
The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible
for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs
actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct
isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DSTN Gene: 
DSTN (destrin (actin depolymerizing factor)) is a protein-coding gene. Diseases associated with DSTN include heroin dependence, and rheumatic disease, and among its related super-pathways are Neurophysiological process Receptor-mediated axon growth repulsion and Development MAG-dependent inhibition of neurite outgrowth. GO annotations related to this gene include actin binding. An important paralog of this gene is CFL2.

UniProtKB/Swiss-Prot: DEST_HUMAN, P60981
Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin).
Acts in a pH-independent manner




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DSTN gene promoter:
         TBP   Spz1   POU3F1   Lmo2   MIF-1   Tal-1beta   MEF-2A   MZF-1   GATA-6   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDSTN promoter sequence
   Search SABiosciences Chromatin IP Primers for DSTN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.1   Ensembl cytogenetic band:  20p12.1   HGNC cytogenetic band: 20p12.1

DSTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSTN gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P017550:  view genomic region     (about GC identifiers)

Start:
17,550,508 bp from pter      End:
17,588,887 bp from pter
Size:
38,380 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DEST_HUMAN, P60981 (See protein sequence)
Recommended Name: Destrin  
Size: 165 amino acids; 18506 Da
Secondary accessions: B2R6N2 B4DYA6 P18282 Q5W166 Q6IAW2
Alternative splicing: 2 isoforms:  P60981-1   P60981-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DSTN: NX_P60981

Explore proteomics data for DSTN at MOPED 

Post-translational modifications:

  • UniProtKB: ISGylated (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P60981

  • DSTN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DSTN Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001011546.1  NP_006861.1  

    ENSEMBL proteins: 
     ENSP00000246069   ENSP00000434355   ENSP00000444808  

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    Novus Biologicals DSTN Proteins
    Novus Biologicals DSTN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DSTN
    Cloud-Clone Corp. Proteins for DSTN 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0015629actin cytoskeleton TAS8399167
    GO:0030864cortical actin cytoskeleton IEA--

    DSTN for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for DSTN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002108 Actin-bd_cofilin/tropomyosin
     IPR017904 ADF/Cofilin/Destrin

    Graphical View of Domain Structure for InterPro Entry P60981

    ProtoNet protein and cluster: P60981

    UniProtKB/Swiss-Prot: DEST_HUMAN, P60981
    Similarity: Belongs to the actin-binding proteins ADF family
    Similarity: Contains 1 ADF-H domain


    DSTN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEST_HUMAN, P60981
    Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin).
    Acts in a pH-independent manner

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    DSTN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DSTN:
     Decreased TP53 protein express 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dstn):
     cardiovascular system  cellular  embryogenesis  immune system  mortality/aging 
     nervous system  normal  vision/eye 

    DSTN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DSTN 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DSTN 
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    SwitchGear 3'UTR luciferase reporter plasmidDSTN 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DSTN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Neurophysiological process Receptor-mediated axon growth repulsion
    Neurophysiological process Receptor-mediated axon growth repulsion0.94
    2Development MAG-dependent inhibition of neurite outgrowth
    Development MAG-dependent inhibition of neurite outgrowth0.87
    3Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    4Androgen receptor signaling pathway
    Androgen receptor signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for DSTN
        Cytoskeleton remodeling CDC42 in cellular processes
    Neurophysiological process Receptor-mediated axon growth repulsion


    3 GeneGo (Thomson Reuters) Pathways for DSTN
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling CDC42 in cellular processes
    Development MAG-dependent inhibition of neurite outgrowth

    1 BioSystems Pathway for DSTN
        Androgen receptor signaling pathway




    DSTN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DSTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/32 Interacting proteins for DSTN (P609812, 3 ENSP000002460694) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607092, 3, ENSP000003499604MINT-66626 I2D: score=5 STRING: ENSP00000349960
    SMAD9O151982, 3MINT-61935 I2D: score=3 
    ACTG1P632612, 3, ENSP000003315144MINT-67797 I2D: score=6 STRING: ENSP00000331514
    GH1P012413, ENSP000003126734I2D: score=1 STRING: ENSP00000312673
    RRBP1Q9P2E93, ENSP000003540454I2D: score=1 STRING: ENSP00000354045
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IEA--
    GO:0006928cellular component movement IEA--
    GO:0008154actin polymerization or depolymerization TAS8399167
    GO:0030042actin filament depolymerization IEA--
    GO:0030836positive regulation of actin filament depolymerization IEA--

    DSTN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DSTN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DSTN (DEST)

    1 DrugBank Compound for DSTN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lauryl Dimethylamine-N-Oxide-- --target--10592235

    7 Novoseek inferred chemical compound relationships for DSTN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phalloidin 48.9 1 9694836 (1)
    isocitrate 34.7 2 17181965 (1), 17269733 (1)
    atp 15.5 5 8399168 (2), 20022956 (1), 16339026 (1), 10623520 (1)
    serine 11.1 4 12673949 (1), 7687605 (1)
    dmso 4.66 3 9078407 (1), 8315023 (1)
    calcium 0 1 11327152 (1)
    threonine 0 1 12673949 (1)

    Search CenterWatch for drugs/clinical trials and news about DSTN / DEST

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DSTN gene (2 alternative transcripts): 
    NM_001011546.1  NM_006870.3  

    Unigene Cluster for DSTN:

    Destrin (actin depolymerizing factor)
    Hs.304192  [show with all ESTs]
    Unigene Representative Sequence: NM_001011546
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246069(uc002wpr.3) ENST00000474024 ENST00000449141 ENST00000543261(uc002wpq.3 uc010gck.3)


    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate DSTN (see all 17):
    hsa-miR-548j hsa-miR-548i hsa-miR-2909 hsa-miR-548s hsa-miR-27b* hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-548w
    SwitchGear 3'UTR luciferase reporter plasmidDSTN 3' UTR sequence
    Inhib. RNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSTN
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    Additional mRNA sequence: 

    AK302338.1 AK308562.1 AK312645.1 AK315994.1 BC009477.2 BX647319.1 CR457042.1 CR541956.1 
    S65738.1 

    23 DOTS entries:

    DT.455864  DT.101966183  DT.97857400  DT.100877062  DT.100877056  DT.91809371  DT.217984  DT.100877070 
    DT.100877066  DT.97767386  DT.100877069  DT.120803525  DT.86853957  DT.100877059  DT.120803523  DT.40270885 
    DT.91838061  DT.95139511  DT.97801688  DT.100810248  DT.40260992  DT.92034806  DT.92452109 

    24/652 AceView cDNA sequences (see all 652):

    AL533931 BM668026 CN482792 BU685531 BM739298 CB215435 BM705952 BG623262 
    BP340874 BP377013 BP341002 AL553445 AA470063 BM671175 AA652977 BP372297 
    BI094139 CR602092 BM704170 BM834892 BX438746 CR604335 CR613178 CA396860 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DSTN (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                                      -     -           -                 -                                 
    SP2:                                                        -           -     -                                 
    SP3:                                      -     -           -           -     -                                 
    SP4:                                      -     -           -           -                                       
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for DSTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DSTN expression in normal human tissues (normalized intensities)      DSTN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DSTN Expression
    About this image


    DSTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             ganglion/cranial/vagus X   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See DSTN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DSTN

    SOURCE GeneReport for Unigene cluster: Hs.304192

    UniProtKB/Swiss-Prot: DEST_HUMAN, P60981
    Tissue specificity: Widely distributed in various tissues

        SABiosciences Expression via Pathway-Focused PCR Array including DSTN: 
              Cytoskeleton Regulators in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DSTN gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dstn1 , 5 destrin1, 5 90.71(n)1
    95.76(a)1
      2 (70.89 cM)5
    564311  NM_019771.21  NP_062745.11 
     1439153205 
    chicken
    (Gallus gallus)
    Aves DSTN1 destrin (actin depolymerizing factor) 84.44(n)
    95.15(a)
      396539  NM_205528.1  NP_990859.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cfl1l6
    cofilin 1 (non-muscle), like
    48(a)
    1 ↔ 1
    13(33831214-33833902)
    fruit fly
    (Drosophila melanogaster)
    Insecta tsr6
    CG68736
    --
    30(a)
    28(a)
    many ↔ many
    many ↔ many
    2R(19931971-19934359)
    X(18633249-18633928)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-606
    Actin-depolymerizing factor 1, isoforms a/b
    21(a)
    1 → many
    V(1474786-1479582)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COF16
    Cofilin, promotes actin filament depolarization in...
    35(a)
    1 → many
    XII(39804-40414)


    ENSEMBL Gene Tree for DSTN (if available)
    TreeFam Gene Tree for DSTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DSTN gene
    CFL22  CFL12  
    2 SIMAP similar genes for DSTN using alignment to 2 protein entries:     DEST_HUMAN (see all proteins):
    CFL1    CFL2

    DSTN for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for DSTN
    PGOHUM00000239634 PGOHUM00000258117 PGOHUM00000241085 PGOHUM00000237998 PGOHUM00000249715


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/873 SNPs in DSTN are shown (see all 873)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364594
    A colorectal cancer sample4--see VAR_0364592 G E mis40--------
    rs106605671,2
    C--17511526(+) ataca-/TTttttt 2 -- int1 trp30--------
    rs1416461151,2
    --17548791(+) AGATAC/TGGGAG 2 -- us2k10--------
    rs61319711,2
    C,H--17548799(+) GAGATA/GGGGCA 2 -- us2k1 tfbs34Minor allele frequency- G:0.04NS CSA WA EA 360
    rs1470635701,2
    --17548929(+) CTCTGA/GTGGCA 2 -- us2k10--------
    rs1476565221,2
    --17549031(+) TCTGAA/TTATTA 2 -- us2k10--------
    rs1867244391,2
    --17549063(+) TCCTAC/GGCAGG 2 -- us2k10--------
    rs107076481,2
    C--17549105(+) ATACAG/-GGGGG 2 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1409428061,2
    C--17549184(+) GCCCAG/TTCTCA 2 -- us2k10--------
    rs1914825131,2
    --17549202(+) TCTTAC/GAAGCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DSTN (17550508 - 17588887 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DSTN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3311CNV Insertion18451855
    dgv4556n71CNV Loss21882294
    nsv510781CNV Loss20534489
    nsv520496CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609114    OMIM disorders: --

    17 diseases for DSTN:    About MalaCards
    heroin dependence    rheumatic disease    myotonic dystrophy    thyroid cancer
    alzheimer's disease    osteoarthritis    thyroiditis    colon cancer
    retinitis    ovarian cancer    pancreatic cancer    lung cancer
    prostate cancer    prostatitis    endotheliitis    neuronitis
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for DSTN:
    Heroin dependence

    DSTN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for DSTN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 7.4 2 8580423 (1), 16339026 (1)
    shock 0 2 9078407 (1), 16035116 (1)
    cancer lung 0 1 16118410 (1)


    Export disorders for DSTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DSTN gene, integrated from 9 sources (see all 142):
    (articles sorted by number of sources associating them with DSTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. (PubMed id 8399167)1, 2, 3, 9 Hawkins M.... Weeds A.G. (1993)
    2. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PubMed id 16815975)1, 2 Wong J.J....Chin K.C. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Destrin, a mammalian actin-depolymerizing protein, is closely related to cofilin. Cloning and expression of porcine brain destrin cDNA. (PubMed id 2156828)1, 3 Moriyama K....Yahara I. (1990)
    8. Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells. (PubMed id 17583572)1, 9 Estornes Y....Abello J. (2007)
    9. Determining the differences in actin binding by human ADF and cofilin. (PubMed id 11812157)1, 9 Yeoh S....Weeds A. (2002)
    10. Tertiary structure of destrin and structural similarity between two actin-regulating protein families. (PubMed id 8674111)1, 9 Hatanaka H....Inagaki F. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11034 HGNC: 15750 AceView: DSTN Ensembl:ENSG00000125868 euGenes: HUgn11034
    ECgene: DSTN H-InvDB: DSTN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DSTN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DSTN gene:
    Search GeneIP for patents involving DSTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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