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Aliases for DSTN Gene

Aliases for DSTN Gene

  • Destrin (Actin Depolymerizing Factor) 2 3
  • ADF 3 4 6
  • Actin-Depolymerizing Factor 3 4
  • ACTDP 3 4
  • BA462D18.2 (Destrin (Actin Depolymerizing Factor ADF) (ACTDP)) 3
  • Epididymis Luminal Protein 32 3
  • BA462D18.2 3
  • Destrin 3
  • HEL32 3
  • DSN 4

External Ids for DSTN Gene

Previous GeneCards Identifiers for DSTN Gene

  • GC20P017539
  • GC20P017545
  • GC20P017498

Summaries for DSTN Gene

Entrez Gene Summary for DSTN Gene

  • The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DSTN Gene

DSTN (Destrin (Actin Depolymerizing Factor)) is a Protein Coding gene. Among its related pathways are Cell adhesion Integrin-mediated cell adhesion and migration and G-protein signaling RAC1 in cellular process. GO annotations related to this gene include actin binding. An important paralog of this gene is CFL2.

UniProtKB/Swiss-Prot for DSTN Gene

  • Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSTN Gene

Genomics for DSTN Gene

Regulatory Elements for DSTN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DSTN Gene

Start:
17,569,863 bp from pter
End:
17,609,919 bp from pter
Size:
40,057 bases
Orientation:
Plus strand

Genomic View for DSTN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DSTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSTN Gene

Proteins for DSTN Gene

  • Protein details for DSTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60981-DEST_HUMAN
    Recommended name:
    Destrin
    Protein Accession:
    P60981
    Secondary Accessions:
    • B2R6N2
    • B4DYA6
    • P18282
    • Q5W166
    • Q6IAW2

    Protein attributes for DSTN Gene

    Size:
    165 amino acids
    Molecular mass:
    18506 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DSTN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DSTN Gene

Proteomics data for DSTN Gene at MOPED

Post-translational modifications for DSTN Gene

Other Protein References for DSTN Gene

No data available for DME Specific Peptides for DSTN Gene

Domains for DSTN Gene

Protein Domains for DSTN Gene

Suggested Antigen Peptide Sequences for DSTN Gene

Graphical View of Domain Structure for InterPro Entry

P60981

UniProtKB/Swiss-Prot:

DEST_HUMAN :
  • P60981
Domain:
  • Contains 1 ADF-H domain.
Family:
  • Belongs to the actin-binding proteins ADF family.
genes like me logo Genes that share domains with DSTN: view

No data available for Gene Families for DSTN Gene

Function for DSTN Gene

Molecular function for DSTN Gene

UniProtKB/Swiss-Prot Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner

Gene Ontology (GO) - Molecular Function for DSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DSTN: view
genes like me logo Genes that share phenotypes with DSTN: view

Animal Model Products

CRISPR Products

miRNA for DSTN Gene

miRTarBase miRNAs that target DSTN

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DSTN Gene

Localization for DSTN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DSTN Gene COMPARTMENTS Subcellular localization image for DSTN gene
Compartment Confidence
cytoskeleton 4
cytosol 3
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for DSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0015629 actin cytoskeleton TAS 8399167
GO:0030864 cortical actin cytoskeleton IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DSTN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DSTN Gene

Pathways for DSTN Gene

genes like me logo Genes that share pathways with DSTN: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component --
GO:0008154 actin polymerization or depolymerization TAS 8399167
GO:0030042 actin filament depolymerization IEA --
GO:0030836 positive regulation of actin filament depolymerization IEA --
GO:0051014 actin filament severing IEA --
genes like me logo Genes that share ontologies with DSTN: view

Compounds for DSTN Gene

(1) Drugbank Compounds for DSTN Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Lauryl Dimethylamine-N-Oxide
target

(7) Novoseek inferred chemical compound relationships for DSTN Gene

Compound -log(P) Hits PubMed IDs
phalloidin 48.9 1
isocitrate 34.7 2
atp 15.5 5
serine 11.1 2
dmso 4.66 2
genes like me logo Genes that share compounds with DSTN: view

Transcripts for DSTN Gene

Unigene Clusters for DSTN Gene

Destrin (actin depolymerizing factor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DSTN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DSTN Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5:
SP6: - -

Relevant External Links for DSTN Gene

GeneLoc Exon Structure for
DSTN
ECgene alternative splicing isoforms for
DSTN

Expression for DSTN Gene

mRNA expression in normal human tissues for DSTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DSTN Gene

This gene is overexpressed in Artery - Tibial (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DSTN Gene

SOURCE GeneReport for Unigene cluster for DSTN Gene Hs.304192

mRNA Expression by UniProt/SwissProt for DSTN Gene

P60981-DEST_HUMAN
Tissue specificity: Widely distributed in various tissues
genes like me logo Genes that share expressions with DSTN: view

In Situ Assay Products

Orthologs for DSTN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DSTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DSTN 35
  • 100 (n)
  • 100 (a)
DSTN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DSTN 35
  • 93.13 (n)
  • 100 (a)
DSTN 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DSTN 35
  • 96.4 (n)
  • 100 (a)
DSTN 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dstn 35
  • 90.71 (n)
  • 95.76 (a)
Dstn 16
Dstn 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DSTN 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
chicken
(Gallus gallus)
Aves DSTN 35
  • 84.44 (n)
  • 95.15 (a)
DSTN 36
  • 95 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cfl1l 36
  • 47 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COF1 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
CSA.4636 36
  • 28 (a)
ManyToMany
Species with no ortholog for DSTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DSTN Gene

ENSEMBL:
Gene Tree for DSTN (if available)
TreeFam:
Gene Tree for DSTN (if available)

Paralogs for DSTN Gene

Paralogs for DSTN Gene

Selected SIMAP similar genes for DSTN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DSTN: view

Variants for DSTN Gene

Sequence variations from dbSNP and Humsavar for DSTN Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1051084 -- 17,607,356(+) TGGCC(A/C)AATGC utr-variant-3-prime
rs1051234 -- 17,608,160(+) CACTT(C/T)GAACG downstream-variant-500B
rs1051235 -- 17,600,859(+) CAGTG(C/T)AGACA reference, missense
rs1051238 -- 17,608,243(+) ACTTA(C/T)CTCTC downstream-variant-500B
rs1407195 -- 17,571,704(+) ATTAT(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DSTN Gene

Variant ID Type Subtype PubMed ID
nsv510781 CNV Loss 20534489
nsv520496 CNV Gain 19592680
dgv4556n71 CNV Loss 21882294
nsv3311 CNV Insertion 18451855

Relevant External Links for DSTN Gene

HapMap Linkage Disequilibrium report
DSTN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSTN Gene

Disorders for DSTN Gene

(1) University of Copenhagen DISEASES for DSTN Gene

(3) Novoseek inferred disease relationships for DSTN Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 7.4 2
shock 0 2
cancer lung 0 1
genes like me logo Genes that share disorders with DSTN: view

No data available for UniProtKB/Swiss-Prot for DSTN Gene

Publications for DSTN Gene

  1. Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. (PMID: 8399167) Hawkins M. … Weeds A.G. (Biochemistry 1993) 2 3 4 23
  2. Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor). (PMID: 12700171) Ikeda S. … Nishina P.M. (Hum. Mol. Genet. 2003) 3 23
  3. Destrin, a mammalian actin-depolymerizing protein, is closely related to cofilin. Cloning and expression of porcine brain destrin cDNA. (PMID: 2156828) Moriyama K. … Yahara I. (J. Biol. Chem. 1990) 2 3
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Proteomic profiling identifies an UV-induced activation of cofilin-1 and destrin in human epidermis. (PMID: 15816841) Hensbergen P. … Tensen C.P. (J. Invest. Dermatol. 2005) 3 23

Products for DSTN Gene

Sources for DSTN Gene

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