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DSTN Gene

protein-coding   GIFtS: 61
GCID: GC20P017550

Destrin (Actin Depolymerizing Factor)

  Search for DSTN
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Destrin (Actin Depolymerizing Factor)1 2     bA462D18.22
ADF2 3 5     BA462D18.2 (Destrin (Actin Depolymerizing Factor ADF) (ACTDP))2
Actin-Depolymerizing Factor2 3     destrin2
ACTDP2 3     Epididymis Luminal Protein 322
HEL322     DSN3

External Ids:    HGNC: 157501   Entrez Gene: 110342   Ensembl: ENSG000001258687   OMIM: 6091145   UniProtKB: P609813   

Export aliases for DSTN gene to outside databases

Previous GC identifers: GC20P017539 GC20P017545 GC20P017498


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DSTN Gene:
The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible
for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs
actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct
isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DSTN Gene:
DSTN (destrin (actin depolymerizing factor)) is a protein-coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is CFL2.

UniProtKB/Swiss-Prot: DEST_HUMAN, P60981
Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin).
Acts in a pH-independent manner




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the DSTN gene promoter:
         TBP   Spz1   POU3F1   Lmo2   MIF-1   Tal-1beta   MEF-2A   MZF-1   GATA-6   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDSTN promoter sequence
   Search Chromatin IP Primers for DSTN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DSTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.1   Ensembl cytogenetic band:  20p12.1   HGNC cytogenetic band: 20p12.1

DSTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSTN gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P017550:  view genomic region     (about GC identifiers)

Start:
17,550,508 bp from pter      End:
17,590,564 bp from pter
Size:
40,057 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DEST_HUMAN, P60981 (See protein sequence)
Recommended Name: Destrin  
Size: 165 amino acids; 18506 Da
Secondary accessions: B2R6N2 B4DYA6 P18282 Q5W166 Q6IAW2
Alternative splicing: 2 isoforms:  P60981-1   P60981-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DSTN: NX_P60981

Explore proteomics data for DSTN at MOPED

Post-translational modifications: 

  • ISGylated (Probable)1
  • Ubiquitination2 at Lys92, Lys114, Lys121
  • Modification sites at PhosphoSitePlus

  • See DSTN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001011546.1  NP_006861.1  

    ENSEMBL proteins: 
     ENSP00000246069   ENSP00000476975   ENSP00000434355  

    DSTN Human Recombinant Protein Products:

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    Novus Biologicals DSTN Proteins
    Novus Biologicals DSTN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DSTN
    Cloud-Clone Corp. Proteins for DSTN

     
    Search eBioscience for Proteins for DSTN 

    DSTN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for DSTN
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    ThermoFisher Antibody for DSTN
    LSBio Antibodies in human, mouse, rat for DSTN

    DSTN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DSTN
    Cloud-Clone Corp. CLIAs for DSTN
    Search eBioscience for ELISAs for DSTN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002108 Actin-bd_cofilin/tropomyosin
     IPR017904 ADF/Cofilin/Destrin

    Graphical View of Domain Structure for InterPro Entry P60981

    ProtoNet protein and cluster: P60981

    UniProtKB/Swiss-Prot: DEST_HUMAN, P60981
    Similarity: Belongs to the actin-binding proteins ADF family
    Similarity: Contains 1 ADF-H domain


    Find genes that share domains with DSTN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEST_HUMAN, P60981
    Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin).
    Acts in a pH-independent manner

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    Find genes that share ontologies with DSTN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DSTN:
     Decreased TP53 protein express 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dstn):
     cardiovascular system  cellular  embryogenesis  immune system  mortality/aging 
     nervous system  normal  vision/eye 

    Find genes that share phenotypes with DSTN           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DSTN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DSTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DSTN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DSTN

    miRNA
    Products:
        
    miRTarBase miRNAs that target DSTN:
    hsa-mir-484 (MIRT041745)

    Block miRNA regulation of human, mouse, rat DSTN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DSTN (see all 17):
    hsa-miR-548j hsa-miR-548i hsa-miR-2909 hsa-miR-548s hsa-miR-27b* hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-548w
    SwitchGear 3'UTR luciferase reporter plasmidDSTN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DSTN
    Predesigned siRNA for gene silencing in human, mouse, rat DSTN

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DSTN

    Clone
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    OriGene clones in human, mouse for DSTN (see all 11)
    OriGene ORF clones in mouse, rat for DSTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DSTN (NM_006870)
    Sino Biological Human cDNA Clone for DSTN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSTN

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DSTN 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSTN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    mitochondrion3
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0015629actin cytoskeleton TAS8399167
    GO:0030864cortical actin cytoskeleton IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with DSTN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DSTN About    
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    2G protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    3Androgen receptor signaling pathway
    Androgen receptor signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for DSTN
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling CDC42 in cellular processes
    Development MAG-dependent inhibition of neurite outgrowth

    1 BioSystems Pathway for DSTN
        Androgen receptor signaling pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including DSTN: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DSTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DSTN (P609812, 3 ENSP000002460694) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607092, 3, ENSP000003499604MINT-66626 I2D: score=5 STRING: ENSP00000349960
    SMAD9O151982, 3MINT-61935 I2D: score=3 
    ACTG1P632612, 3, ENSP000003315144MINT-67797 I2D: score=6 STRING: ENSP00000331514
    GH1P012413, ENSP000003126734I2D: score=1 STRING: ENSP00000312673
    SSH1Q8WYL53, ENSP000003157134I2D: score=1 STRING: ENSP00000315713
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis ----
    GO:0006928cellular component movement IEA--
    GO:0008154actin polymerization or depolymerization TAS8399167
    GO:0030042actin filament depolymerization IEA--
    GO:0030836positive regulation of actin filament depolymerization IEA--

    Find genes that share ontologies with DSTN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DSTN (DEST)

    1 DrugBank Compound for DSTN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lauryl Dimethylamine-N-Oxide-- --target--10592235

    7 Novoseek inferred chemical compound relationships for DSTN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phalloidin 48.9 1 9694836 (1)
    isocitrate 34.7 2 17181965 (1), 17269733 (1)
    atp 15.5 5 8399168 (2), 20022956 (1), 16339026 (1), 10623520 (1)
    serine 11.1 4 12673949 (1), 7687605 (1)
    dmso 4.66 3 9078407 (1), 8315023 (1)
    calcium 0 1 11327152 (1)
    threonine 0 1 12673949 (1)



    Find genes that share compounds with DSTN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DSTN gene (2 alternative transcripts): 
    NM_001011546.1  NM_006870.3  

    Unigene Cluster for DSTN:

    Destrin (actin depolymerizing factor)
    Hs.304192  [show with all ESTs]
    Unigene Representative Sequence: NM_001011546
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246069(uc002wpr.3) ENST00000474024 ENST00000449141
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DSTN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DSTN (see all 17):
    hsa-miR-548j hsa-miR-548i hsa-miR-2909 hsa-miR-548s hsa-miR-27b* hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-548w
    SwitchGear 3'UTR luciferase reporter plasmidDSTN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DSTN
    Predesigned siRNA for gene silencing in human, mouse, rat DSTN
    Clone
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    OriGene clones in human, mouse for DSTN (see all 11)
    OriGene ORF clones in mouse, rat for DSTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DSTN (NM_006870)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSTN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DSTN
    OriGene qSTAR qPCR primer pairs in human, mouse for DSTN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DSTN
      QuantiTect SYBR Green Assays in human, mouse, rat DSTN
      QuantiFast Probe-based Assays in human, mouse, rat DSTN

    Additional mRNA sequence: 

    AK302338.1 AK308562.1 AK312645.1 AK315994.1 BC009477.2 BX647319.1 CR457042.1 CR541956.1 
    S65738.1 

    23 DOTS entries:

    DT.455864  DT.101966183  DT.97857400  DT.100877062  DT.100877056  DT.91809371  DT.217984  DT.100877070 
    DT.100877066  DT.97767386  DT.100877069  DT.120803525  DT.86853957  DT.100877059  DT.120803523  DT.40270885 
    DT.91838061  DT.95139511  DT.97801688  DT.100810248  DT.40260992  DT.92034806  DT.92452109 

    Selected AceView cDNA sequences (see all 652):

    CR604335 BX460466 AI803116 BU838073 BM671175 BF727154 BQ719753 CB137620 
    CR610796 CR623027 CB215435 CR613178 BX438746 BP375057 BU844467 CD242783 
    CD516049 CR623701 BI094139 CB150243 CB120691 BM705952 BP374551 BM310635 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DSTN (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                                      -     -           -                 -                                 
    SP2:                                                        -           -     -                                 
    SP3:                                      -     -           -           -     -                                 
    SP4:                                      -     -           -           -                                       
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for DSTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DSTN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DSTN Expression
    About this image


    DSTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Corneal Stroma
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    DSTN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DSTN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.304192

    UniProtKB/Swiss-Prot: DEST_HUMAN, P60981
    Tissue specificity: Widely distributed in various tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including DSTN: 
              Cytoskeleton Regulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DSTN
    OriGene qSTAR qPCR primer pairs in human, mouse for DSTN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DSTN
    QuantiTect SYBR Green Assays in human, mouse, rat DSTN
    QuantiFast Probe-based Assays in human, mouse, rat DSTN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DSTN gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dstn1 , 5 destrin1, 5 90.71(n)1
    95.76(a)1
      2 (70.89 cM)5
    564311  NM_019771.21  NP_062745.11 
     1439153205 
    chicken
    (Gallus gallus)
    Aves DSTN1 destrin (actin depolymerizing factor) 84.44(n)
    95.15(a)
      396539  NM_205528.1  NP_990859.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cfl1l6
    cofilin 1 (non-muscle), like
    47(a)
    many ↔ many
    13(33831214-33833902) ENSDARG00000012972
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COF16
    Cofilin, promotes actin filament depolarization in...
    38(a)
    1 → many
    XII(39804-40414) YLL050C


    ENSEMBL Gene Tree for DSTN (if available)
    TreeFam Gene Tree for DSTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DSTN gene
    CFL22  CFL12  
    2 SIMAP similar genes for DSTN using alignment to 2 protein entries:     DEST_HUMAN (see all proteins):
    CFL1    CFL2

    Find genes that share paralogs with DSTN           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for DSTN
    PGOHUM00000239634 PGOHUM00000258117 PGOHUM00000241085 PGOHUM00000237998 PGOHUM00000249715


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DSTN (see all 873)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364594
    A colorectal cancer sample4--see VAR_0364592 G E mis40--------
    rs106605671,2
    C--17511526(+) ataca-/TTttttt 2 -- int1 trp30--------
    rs1416461151,2
    --17548791(+) AGATAC/TGGGAG 2 -- us2k10--------
    rs61319711,2
    C,H--17548799(+) GAGATA/GGGGCA 2 -- us2k1 tfbs34Minor allele frequency- G:0.04NS CSA WA EA 360
    rs1470635701,2
    --17548929(+) CTCTGA/GTGGCA 2 -- us2k10--------
    rs1476565221,2
    --17549031(+) TCTGAA/TTATTA 2 -- us2k10--------
    rs1867244391,2
    --17549063(+) TCCTAC/GGCAGG 2 -- us2k10--------
    rs107076481,2
    C--17549105(+) ATACAG/-GGGGG 2 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1409428061,2
    C--17549184(+) GCCCAG/TTCTCA 2 -- us2k10--------
    rs1914825131,2
    --17549202(+) TCTTAC/GAAGCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DSTN (17550508 - 17590564 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DSTN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3311CNV Insertion18451855
    dgv4556n71CNV Loss21882294
    nsv510781CNV Loss20534489
    nsv520496CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609114    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DSTN:
    Heroin dependence

    Find genes that share disorders with DSTN           About GenesLikeMe

    3 Novoseek inferred disease relationships for DSTN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 7.4 2 8580423 (1), 16339026 (1)
    shock 0 2 9078407 (1), 16035116 (1)
    cancer lung 0 1 16118410 (1)


    Export disorders for DSTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DSTN gene, integrated from 10 sources (see all 146):
    (articles sorted by number of sources associating them with DSTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. (PubMed id 8399167)1, 2, 3, 9 Hawkins M.... Weeds A.G. (Biochemistry 1993)
    2. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PubMed id 16815975)1, 2 Wong J.J.... Chin K.C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Destrin, a mammalian actin-depolymerizing protein, is closely related to cofilin. Cloning and expression of porcine brain destrin cDNA. (PubMed id 2156828)1, 3 Moriyama K....Yahara I. (J. Biol. Chem. 1990)
    8. Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells. (PubMed id 17583572)1, 9 Estornes Y....Abello J. (Int. J. Cancer 2007)
    9. Determining the differences in actin binding by human ADF and cofilin. (PubMed id 11812157)1, 9 Yeoh S....Weeds A. (J. Mol. Biol. 2002)
    10. Tertiary structure of destrin and structural similarity between two actin-regulating protein families. (PubMed id 8674111)1, 9 Hatanaka H....Inagaki F. (Cell 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 11034 HGNC: 15750 AceView: DSTN Ensembl:ENSG00000125868 euGenes: HUgn11034
    ECgene: DSTN H-InvDB: DSTN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DSTN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DSTN gene:
    Search GeneIP for patents involving DSTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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