Aliases for DSTN Gene
External Ids for DSTN Gene
Previous GeneCards Identifiers for DSTN Gene
The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DSTN Gene
DSTN (Destrin, Actin Depolymerizing Factor) is a Protein Coding gene. Diseases associated with DSTN include necatoriasis. Among its related pathways are G-protein signaling RAC1 in cellular process and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include actin binding. An important paralog of this gene is CFL2.
UniProtKB/Swiss-Prot for DSTN Gene
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.