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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DSTN Gene

protein-coding GIFtS: 59
GCID: GC20P017550

destrin (actin depolymerizing factor)

Explore 15 diseases affiliated with
DSTN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Destrin (Actin Depolymerizing Factor)¹ ²		BA462D18.2¹
ADF¹ ² ³ ⁵		BA462D18.2 (Destrin (Actin Depolymerizing Factor ADF) (ACTDP))²
ACTDP¹ ² ³		Destrin¹
Actin-Depolymerizing Factor² ³		DSN³

External Ids:	HGNC: 15750¹	Entrez Gene: 11034²	Ensembl: ENSG00000125868⁷	OMIM: 609114⁵	UniProtKB: P60981³

Export aliases for DSTN gene to outside databases

Previous GC identifers: GC20P017539 GC20P017545 GC20P017498

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DSTN:

The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for

enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin

filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have

been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DEST_HUMAN, P60981

Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in

a pH-independent manner

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DSTN gene promoter:
TBP Spz1 POU3F1 Lmo2 MIF-1 Tal-1beta MEF-2A MZF-1 GATA-6 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DSTN promoter sequence

Search SABiosciences Chromatin IP Primers for DSTN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSTN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.1 Ensembl cytogenetic band: 20p12.1 HGNC cytogenetic band: 20p12.1

DSTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSTN gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P017550: view genomic region (about GC identifiers)

Start:	17,550,508 bp from pter	End:	17,588,887 bp from pter
Size:	38,380 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DEST_HUMAN, P60981 (See protein sequence)

Recommended Name: Destrin

Size: 165 amino acids; 18506 Da

Secondary accessions: B2R6N2 B4DYA6 P18282 Q5W166 Q6IAW2

Alternative splicing: 2 isoforms: P60981-1 P60981-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DSTN: NX_P60981

Post-translational modifications:

ISGylated (Probable)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P60981

DSTN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001011546.1 NP_006861.1

ENSEMBL proteins:

ENSP00000246069 ENSP00000434355 ENSP00000444808

Human Recombinant Protein Products for DSTN:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: DSTN OriGene Protein Over-expression Lysate (see all 2): DSTN OriGene Custom Protein Services for DSTN
	GenScript Custom Purified and Recombinant Proteins Services for DSTN
	Novus Biologicals DSTN Proteins Novus Biologicals DSTN Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for DSTN
	Uscn Proteins for DSTN

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	--	--
GO:0015629	actin cytoskeleton	TAS	8399167
GO:0030864	cortical actin cytoskeleton	IEA	--

DSTN for ontologies About GeneDecksing

DSTN Antibody Products:

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	GenScript Custom Superior Antibodies Services for DSTN
	Novus Biologicals DSTN Antibodies
	Abcam antibodies for DSTN
	Uscn Antibodies for DSTN
	ThermoFisher Antibody for DSTN

Assay Products for DSTN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DSTN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DSTN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DSTN for domains About GeneDecksing

2 InterPro domains/families:

IPR002108 Actin-bd_cofilin/tropomyosin

IPR017904 ADF/Cofilin/Destrin

Graphical View of Domain Structure for InterPro Entry P60981

ProtoNet protein and cluster: P60981

UniProtKB/Swiss-Prot: DEST_HUMAN, P60981

Similarity: Belongs to the actin-binding proteins ADF family

Similarity: Contains 1 ADF-H domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DEST_HUMAN, P60981

Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in

a pH-independent manner

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--

DSTN for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DSTN:

Decreased TP53 protein express

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dstn):

cardiovascular system	cellular	immune system	nervous system	normal
vision/eye

DSTN for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DSTN

miRNA Products:		OriGene 3'-UTR Clone (see all 2): DSTN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DSTN
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate DSTN (see all 17):
		hsa-miR-548j hsa-miR-548i hsa-miR-2909 hsa-miR-548s hsa-miR-27b* hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-548w

		SwitchGear 3'UTR luciferase reporter plasmid: DSTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DSTN (see all 7) OriGene shRNA RFP: DSTN Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSTN
		Sirion Biotech Custom design and validation of potent shRNA sequences against DSTN

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DSTN
			Sirion Biotech Customized adenovirus for overexpression of DSTN Sirion Biotech Customized adenovirus for potent knockdown of DSTN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DSTN (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DSTN (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DSTN (NM_006870)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSTN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSTN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DSTN
		Search LifeMap BioReagents cell lines for DSTN
		Sirion Biotech Customized stable knockdown cell line services for DSTN Sirion Biotech Customized inducible knockdown cell line services for DSTN Sirion Biotech Customized stable overexpressing cell line services for DSTN Sirion Biotech Customized inducible overexpressing cell line services for DSTN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSTN

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Neurophysiological process Receptor-mediated axon growth repulsion

Neurophysiological process Receptor-mediated axon growth repulsion

1.00

Neurophysiological process_Receptor-mediated axon growth repulsion

0.94

G-protein signaling_RAC1 in cellular process

Cytoskeleton remodeling_CDC42 in cellular processes

0.37

Cytoskeleton remodeling CDC42 in cellular processes

0.37

Androgen receptor signaling pathway

Androgen receptor signaling pathway

1.00

Development MAG-dependent inhibition of neurite outgrowth

Development_MAG-dependent inhibition of neurite outgrowth

0.87

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for DSTN

	Cytoskeleton remodeling CDC42 in cellular processes
	Neurophysiological process Receptor-mediated axon growth repulsion

3 GeneGo (Thomson Reuters) Pathways for DSTN

	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling CDC42 in cellular processes
	Development MAG-dependent inhibition of neurite outgrowth

1 BioSystems Pathway for DSTN

Androgen receptor signaling pathway

DSTN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DSTN

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/32 Interacting proteins for DSTN (P60981^{2, 3} ENSP00000246069⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACTB	P60709²^,³, ENSP00000349960⁴	MINT-66626 I2D: score=5 STRING: ENSP00000349960
SMAD9	O15198²^,³	MINT-61935 I2D: score=3
ACTG1	P63261²^,³, ENSP00000331514⁴	MINT-67797 I2D: score=6 STRING: ENSP00000331514
GH1	P01241³, ENSP00000312673⁴	I2D: score=1 STRING: ENSP00000312673
RRBP1	Q9P2E9³, ENSP00000354045⁴	I2D: score=1 STRING: ENSP00000354045

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000910	cytokinesis	IEA	--
GO:0006928	cellular component movement	IEA	--
GO:0008154	actin polymerization or depolymerization	TAS	8399167
GO:0030836	positive regulation of actin filament depolymerization	IEA	--
GO:0051014	actin filament severing	TAS	8399167

DSTN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DSTN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DSTN

1 DrugBank Compound for DSTN About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Lauryl Dimethylamine-N-Oxide	--	--	target	--	10592235

7 Novoseek chemical compound relationships for DSTN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phalloidin	48.9	1	9694836 (1)
isocitrate	34.7	2	17181965 (1), 17269733 (1)
atp	15.5	5	8399168 (2), 20022956 (1), 16339026 (1), 10623520 (1)
serine	11.1	4	12673949 (1), 7687605 (1)
dmso	4.66	3	9078407 (1), 8315023 (1)
calcium	0	1	11327152 (1)
threonine	0	1	12673949 (1)

Search CenterWatch for drugs/clinical trials and news about DSTN / DEST

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DSTN gene (2 alternative transcripts):

NM_001011546.1 NM_006870.3

Unigene Cluster for DSTN:

Destrin (actin depolymerizing factor)

Hs.304192 [show with all ESTs]

Unigene Representative Sequence: NM_001011546

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000246069(uc002wpr.3) ENST00000474024 ENST00000449141 ENST00000543261(uc002wpq.3 uc010gck.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): DSTN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DSTN
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate DSTN (see all 17):
		hsa-miR-548j hsa-miR-548i hsa-miR-2909 hsa-miR-548s hsa-miR-27b* hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-548w

		SwitchGear 3'UTR luciferase reporter plasmid: DSTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DSTN (see all 7) OriGene shRNA RFP: DSTN Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSTN
		Sirion Biotech Custom design and validation of potent shRNA sequences against DSTN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DSTN (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DSTN (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DSTN (NM_006870)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSTN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSTN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DSTN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DSTN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSTN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSTN

Additional cDNA sequence:

AK302338.1 AK308562.1 AK312645.1 AK315994.1 BC009477.2 BX647319.1 CR457042.1 CR541956.1

S65738.1

24/26 DOTS entries (see all 26):

DT.455864 DT.101966183 DT.97857400 DT.100877062 DT.100877056 DT.91809371 DT.217984 DT.100877070

DT.100877066 DT.92452110 DT.97767386 DT.86853957 DT.100877069 DT.120803525 DT.100877059 DT.120803523

DT.40270885 DT.91691799 DT.91838061 DT.92034806 DT.92452109 DT.95139511 DT.97801688 DT.100810248

24/652 AceView cDNA sequences (see all 652):

BE394028 CR598189 CR604335 AI803116 CA434281 CB107482 BQ721614 BU580903

CR622679 BX460466 CR610796 BU838073 BU685531 AW517614 BM671175 BP375057

CR541956 CD679229 AL533931 CR601160 CN482792 BU164813 BQ723503 BM542202

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DSTN (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f
SP1:													-		-				-						-
SP2:																			-				-		-
SP3:													-		-				-				-		-
SP4:													-		-				-				-
SP5:

ECgene alternative splicing isoforms for DSTN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DSTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

DSTN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Eye

Gut Tube

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DSTN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DSTN

SOURCE GeneReport for Unigene cluster: Hs.304192

UniProtKB/Swiss-Prot: DEST_HUMAN, P60981

Tissue specificity: Widely distributed in various tissues

SABiosciences Expression via Pathway-Focused PCR Array including DSTN:

Cytoskeleton Regulators in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DSTN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DSTN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSTN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSTN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSTN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DSTN gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dstn^{1 , 5}	destrin^{1, 5}	90.71(n)¹ 95.76(a)¹		2 (70.89 cM)⁵ 56431¹ NM_019771.2¹ NP_062745.1¹ 143915320⁵
chicken (Gallus gallus)	Aves	DSTN¹	destrin (actin depolymerizing factor)	84.44(n) 95.15(a)		396539 NM_205528.1 NP_990859.1
zebrafish (Danio rerio)	Actinopterygii	cfl1l⁶	cofilin 1 (non-muscle), like	45(a)	1 ↔ 1	13(33831214-33833902)
fruit fly (Drosophila melanogaster)	Insecta	tsr⁶ CG6873⁶	--	32(a) 29(a)	many ↔ many many ↔ many	2R(19931971-19934359) X(18633249-18633928)
worm (Caenorhabditis elegans)	Secernentea	unc-60⁶	Actin-depolymerizing factor 1, isoforms a/b	18(a)	1 → many	V(1474786-1479582)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATADF4⁶ ADF7⁶ (see all 12)	actin depolymerizing factor 7 (see all 12)	32(a) 31(a) (see all 12)	many ↔ many many ↔ many (see all 12)	5(24122412-24123912) 4(13058936-13060107)
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	actin-depolymerizing factor, putative, expressed (see all 10)	32(a) 31(a) (see all 10)	many ↔ many many ↔ many (see all 10)	7(17739695-17741322) 3(32353444-32356711)

ENSEMBL Gene Tree for DSTN (if available)
TreeFam Gene Tree for DSTN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DSTN gene

CFL2² CFL1²

2 SIMAP similar genes for DSTN using alignment to 2 protein entries: DEST_HUMAN (see all proteins):

CFL1 CFL2

DSTN for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for DSTN
PGOHUM00000239634 PGOHUM00000258117 PGOHUM00000241085 PGOHUM00000237998 PGOHUM00000249715

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141646115^1,2		--	17548791(+)	`AGATAC/TGGGAG`	2	--	us2k¹		0	--	--	--	--
rs6131971^1,2	C,H	--	17548799(+)	`GAGATA/GGGGCA`	2	--	us2k¹ tfbs³		4		NS CSA WA EA	360
rs147063570^1,2		--	17548929(+)	`CTCTGA/GTGGCA`	2	--	us2k¹		0	--	--	--	--
rs147656522^1,2		--	17549031(+)	`TCTGAA/TTATTA`	2	--	us2k¹		0	--	--	--	--
rs186724439^1,2		--	17549063(+)	`TCCTAC/GGCAGG`	2	--	us2k¹		0	--	--	--	--
rs10707648^1,2	C	--	17549105(+)	`ATACAG/-GGGGG`	2	--	us2k¹		1		NA	2
rs140942806^1,2		--	17549184(+)	`GCCCAG/TTCTCA`	2	--	us2k¹		0	--	--	--	--
rs191482513^1,2		--	17549202(+)	`TCTTAC/GAAGCA`	2	--	us2k¹		0	--	--	--	--
rs183199534^1,2		--	17549205(+)	`TAGAAG/TCAGTG`	2	--	us2k¹		0	--	--	--	--
rs2180823^1,2	C	--	17549391(+)	`GGGTTT/CCTATG`	2	--	us2k¹		12		NA WA CSA EA	374

HapMap Linkage Disequilibrium report for DSTN (17550508 - 17588887 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DSTN
1 CNV: 50626

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DSTN for disorders           About GeneDecksing

OMIM gene information: 609114    OMIM disorders: --

15 diseases for DSTN:    About MalaCards

heroin dependence myotonic dystrophy alzheimer's disease colon cancer

osteoarthritis thyroid cancer ovarian cancer thyroiditis

lung cancer prostate cancer retinitis prostatitis

immunodeficiency malaria neuronitis

1 disease from the University of Copenhagen DISEASES database for DSTN:

Heroin dependence

3 Novoseek disease relationships for DSTN gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	7.4	2	8580423 (1), 16339026 (1)
shock	0	2	9078407 (1), 16035116 (1)
cancer lung	0	1	16118410 (1)

Export disorders for DSTN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DSTN gene, integrated from 9 sources (see all 136):
(articles sorted by number of sources associating them with DSTN)

Utopia: connect your pdf to the dynamic
world of online information

Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. (PubMed id 8399167)^{1, 2, 3, 9} Hawkins M.... Weeds A.G. (1993)
HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PubMed id 16815975)^{1, 2} Wong J.J....Chin K.C. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Destrin, a mammalian actin-depolymerizing protein, is closely related to cofilin. Cloning and expression of porcine brain destrin cDNA. (PubMed id 2156828)^{1, 3} Moriyama K....Yahara I. (1990)
Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells. (PubMed id 17583572)^{1, 9} Estornes Y....Abello J. (2007)
Determining the differences in actin binding by human ADF and cofilin. (PubMed id 11812157)^{1, 9} Yeoh S....Weeds A. (2002)
Tertiary structure of destrin and structural similarity between two actin-regulating protein families. (PubMed id 8674111)^{1, 9} Hatanaka H....Inagaki F. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11034	HGNC: 15750	AceView: DSTN	Ensembl:ENSG00000125868	euGenes: HUgn11034
ECgene: DSTN	H-InvDB: DSTN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DSTN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DSTN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DSTN gene:
Search GeneIP for patents involving DSTN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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destrin (actin depolymerizing factor)

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