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Aliases for DSTN Gene

Aliases for DSTN Gene

  • Destrin, Actin Depolymerizing Factor 2 3 5
  • Actin-Depolymerizing Factor 3 4
  • ACTDP 3 4
  • ADF 3 4
  • BA462D18.2 (Destrin (Actin Depolymerizing Factor ADF) (ACTDP)) 3
  • Destrin (Actin Depolymerizing Factor) 2
  • Epididymis Luminal Protein 32 3
  • BA462D18.2 3
  • Destrin 3
  • HEL32 3
  • DSN 4

External Ids for DSTN Gene

Previous GeneCards Identifiers for DSTN Gene

  • GC20P017539
  • GC20P017545
  • GC20P017498

Summaries for DSTN Gene

Entrez Gene Summary for DSTN Gene

  • The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DSTN Gene

DSTN (Destrin, Actin Depolymerizing Factor) is a Protein Coding gene. Diseases associated with DSTN include Necatoriasis. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Development Slit-Robo signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is CFL1.

UniProtKB/Swiss-Prot for DSTN Gene

  • Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSTN Gene

Genomics for DSTN Gene

Regulatory Elements for DSTN Gene

Enhancers for DSTN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G017556 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.5 -10.3 -10323 5.4 PKNOX1 FOXA2 MLX ARID4B SIN3A SLC30A9 ZNF143 FOS DEK ZNF263 RRBP1 DSTN POLR3F GCNT1P1 ENSG00000277373 GC20P017516
GH20G017593 1.3 Ensembl ENCODE dbSUPER 23.9 +25.4 25421 2.1 HDGF NFIB TEAD4 SIN3A RAD21 ZNF697 ZKSCAN1 CTBP1 GATA3 FOS DSTN POLR3F BFSP1 LOC100286962 RRBP1 GC20M017577 RN7SKP69
GH20G017609 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +43.7 43679 7.0 HDGF NFIB ZFP64 SIN3A FEZF1 THRB RAD21 GLIS2 ZNF143 FOS DSTN RRBP1 POLR3F LOC100286962 PIR41690
GH20G017588 1.1 dbSUPER 21.7 +20.0 20028 1.1 HNRNPUL1 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 FEZF1 ZBTB7B YY1 DSTN POLR3F RRBP1 RN7SKP69 LOC100286962 GC20M017577
GH20G017566 1.3 ENCODE dbSUPER 17.8 +1.1 1072 6.5 HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 RRBP1 DSTN POLR3F BANF2 BFSP1 RN7SKP69 GC20M017577
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DSTN on UCSC Golden Path with GeneCards custom track

Promoters for DSTN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000135133 1227 3201 HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1

Genomic Location for DSTN Gene

Chromosome:
20
Start:
17,569,173 bp from pter
End:
17,609,919 bp from pter
Size:
40,747 bases
Orientation:
Plus strand

Genomic View for DSTN Gene

Genes around DSTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DSTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DSTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSTN Gene

Proteins for DSTN Gene

  • Protein details for DSTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60981-DEST_HUMAN
    Recommended name:
    Destrin
    Protein Accession:
    P60981
    Secondary Accessions:
    • B2R6N2
    • B4DYA6
    • P18282
    • Q5W166
    • Q6IAW2

    Protein attributes for DSTN Gene

    Size:
    165 amino acids
    Molecular mass:
    18506 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DSTN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DSTN Gene

Post-translational modifications for DSTN Gene

Other Protein References for DSTN Gene

No data available for DME Specific Peptides for DSTN Gene

Domains & Families for DSTN Gene

Protein Domains for DSTN Gene

Suggested Antigen Peptide Sequences for DSTN Gene

Graphical View of Domain Structure for InterPro Entry

P60981

UniProtKB/Swiss-Prot:

DEST_HUMAN :
  • Belongs to the actin-binding proteins ADF family.
Family:
  • Belongs to the actin-binding proteins ADF family.
genes like me logo Genes that share domains with DSTN: view

No data available for Gene Families for DSTN Gene

Function for DSTN Gene

Molecular function for DSTN Gene

UniProtKB/Swiss-Prot Function:
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.

Gene Ontology (GO) - Molecular Function for DSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0051015 actin filament binding IDA 8399167
genes like me logo Genes that share ontologies with DSTN: view
genes like me logo Genes that share phenotypes with DSTN: view

Animal Models for DSTN Gene

MGI Knock Outs for DSTN:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DSTN Gene

Localization for DSTN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DSTN gene
Compartment Confidence
extracellular 5
cytoskeleton 5
mitochondrion 3
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for DSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0015629 actin cytoskeleton IEA,TAS 8399167
GO:0030864 cortical actin cytoskeleton IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DSTN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DSTN Gene

Pathways & Interactions for DSTN Gene

genes like me logo Genes that share pathways with DSTN: view

Gene Ontology (GO) - Biological Process for DSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008154 actin polymerization or depolymerization TAS 8399167
GO:0030042 actin filament depolymerization IDA,IEA 11812157
GO:0030043 actin filament fragmentation IEA --
GO:0030836 positive regulation of actin filament depolymerization IEA --
GO:0051014 actin filament severing IEA --
genes like me logo Genes that share ontologies with DSTN: view

No data available for SIGNOR curated interactions for DSTN Gene

Drugs & Compounds for DSTN Gene

(6) Drugs for DSTN Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lauryl Dimethylamine-N-Oxide Experimental Pharma Target 0

(2) Additional Compounds for DSTN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DSTN: view

Transcripts for DSTN Gene

Unigene Clusters for DSTN Gene

Destrin (actin depolymerizing factor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DSTN Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5:
SP6: - -

Relevant External Links for DSTN Gene

GeneLoc Exon Structure for
DSTN
ECgene alternative splicing isoforms for
DSTN

Expression for DSTN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DSTN Gene

mRNA differential expression in normal tissues according to GTEx for DSTN Gene

This gene is overexpressed in Artery - Tibial (x6.4).

Protein differential expression in normal tissues from HIPED for DSTN Gene

This gene is overexpressed in Colon muscle (10.2) and Cardia (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DSTN Gene



Protein tissue co-expression partners for DSTN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DSTN Gene:

DSTN

SOURCE GeneReport for Unigene cluster for DSTN Gene:

Hs.304192

mRNA Expression by UniProt/SwissProt for DSTN Gene:

P60981-DEST_HUMAN
Tissue specificity: Widely distributed in various tissues.

Evidence on tissue expression from TISSUES for DSTN Gene

  • Nervous system(4.9)
  • Lung(4.6)
  • Blood(4.4)
  • Heart(3.3)
  • Intestine(2.9)
  • Muscle(2.8)
  • Kidney(2.6)
  • Eye(2.5)
  • Spleen(2.4)
  • Gall bladder(2.3)
  • Liver(2.3)
  • Stomach(2.3)
  • Adrenal gland(2.2)
  • Skin(2.2)
  • Thyroid gland(2.2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with DSTN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DSTN Gene

Orthologs for DSTN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DSTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DSTN 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia DSTN 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 99 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DSTN 34 35
  • 96.4 (n)
cow
(Bos Taurus)
Mammalia DSTN 34 35
  • 93.13 (n)
mouse
(Mus musculus)
Mammalia Dstn 34 16 35
  • 90.71 (n)
chicken
(Gallus gallus)
Aves DSTN 34 35
  • 84.44 (n)
zebrafish
(Danio rerio)
Actinopterygii cfl1l 35
  • 47 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COF1 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4636 35
  • 28 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
Species where no ortholog for DSTN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DSTN Gene

ENSEMBL:
Gene Tree for DSTN (if available)
TreeFam:
Gene Tree for DSTN (if available)

Paralogs for DSTN Gene

Paralogs for DSTN Gene

(2) SIMAP similar genes for DSTN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DSTN: view

Variants for DSTN Gene

Sequence variations from dbSNP and Humsavar for DSTN Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_036459 A colorectal cancer sample
rs1000011717 -- 17,605,741(+) TCCTT(A/G)TTATC intron-variant
rs1000110313 -- 17,579,970(+) AATAG(A/T)TCAAA intron-variant
rs1000141934 -- 17,589,147(+) TAATC(C/T)CATTT intron-variant
rs1000269101 -- 17,586,238(+) TACAA(C/G)CTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DSTN Gene

Variant ID Type Subtype PubMed ID
esv3645426 CNV gain 21293372
nsv3311 CNV insertion 18451855
nsv510781 CNV deletion 20534489
nsv520496 CNV gain 19592680
nsv965857 CNV duplication 23825009

Variation tolerance for DSTN Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DSTN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DSTN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSTN Gene

Disorders for DSTN Gene

MalaCards: The human disease database

(1) MalaCards diseases for DSTN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
necatoriasis
- elite association - COSMIC cancer census association via MalaCards
Search DSTN in MalaCards View complete list of genes associated with diseases

Relevant External Links for DSTN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DSTN
genes like me logo Genes that share disorders with DSTN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DSTN Gene

Publications for DSTN Gene

  1. Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. (PMID: 8399167) Hawkins M. … Weeds A.G. (Biochemistry 1993) 2 3 4 22 64
  2. Determining the differences in actin binding by human ADF and cofilin. (PMID: 11812157) Yeoh S. … Weeds A. (J. Mol. Biol. 2002) 3 4 22 64
  3. Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells. (PMID: 17583572) Estornes Y. … Abello J. (Int. J. Cancer 2007) 3 22 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PMID: 16815975) Wong J.J. … Chin K.C. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 64

Products for DSTN Gene

Sources for DSTN Gene

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