DSPP Gene
protein-coding GIFtS: 50
GCID: GC04P088529
|
|
dentin sialophosphoprotein
(Previous symbols: DFNA39, DGI1)
| |
Aliases
for DSPP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dentin Sialophosphoprotein1 2 | | DSP2 | | DFNA391 2 5 | | Dentin Phosphophoryn2 | | DGI11 2 5 | | Dentin Phosphoprotein2 | | DMP31 2 | | Dentin Phosphoryn2 | | DPP2 5 | | Dentin Sialoprotein2 | | DTDP22 5 | | |
Export aliases for DSPP gene to outside databasesPrevious GC identifers: GC04P088687 GC04P088831 GC04P088988 GC04P088886 GC04P084275 |
Summaries
for DSPP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DSPP:
This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secretedby odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to beinvolved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesisimperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form ofdeafness. Allelic differences due to repeat polymorphisms have been found for this gene. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: DSPP_HUMAN, Q9NZW4Function: DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initialmineralization of dentin matrix collagen as well as regulate the size and shape of the crystals
Gene Wiki entry for DSPP (Dentin sialophosphoprotein)
|
Genomic Views
for DSPP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DSPP gene promoter:
c-Fos S8 AP-1 Pax-6 ATF-2 c-Jun FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DSPP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSPP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q21.3 Ensembl cytogenetic band: 4q22.1 HGNC cytogenetic band: 4q21.3DSPP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P088529: view genomic region
(about GC identifiers)
Start:
|
88,529,681 bp from pter |
End:
|
88,538,062 bp from pter |
Size:
|
8,382 bases |
Orientation:
|
plus strand |
|
Proteins
for DSPP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DSPP_HUMAN, Q9NZW4 (See
protein sequence)Recommended Name: Dentin sialophosphoprotein precursor Size: 1301 amino acids; 131151 Da
Subunit: Interacts with FBLN7 (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: A8MUI0 O95815Explore the universe of human proteins at neXtProt for DSPP: NX_Q9NZW4
Post-translational modifications:
DSP is glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZW4
DSPP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055023.2
ENSEMBL proteins: ENSP00000282478 ENSP00000382213
Human Recombinant Protein Products for DSPP:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005578 | proteinaceous extracellular matrix |
IEA | -- |
DSPP for ontologies About GeneDecksing
DSPP Antibody Products:
Assay Products for DSPP: |
Protein
Domains /
Families
for DSPP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NZW4 |
Function
for DSPP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DSPP_HUMAN, Q9NZW4Function: DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initialmineralization of dentin matrix collagen as well as regulate the size and shape of the crystals Genatlas biochemistry entry for DSPP:dentin sialophosphoprotein,precursor of dentin sialoprotein (DSP) and dentin phosphoprotein,non collagenous componentsof the dentin extra-cellular matrix,tooth specific,encoded by a bicistronic transcript
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
DSPP for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for DSPP:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Dspp):
DSPP for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DSPP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DSPP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DSPP (NM_014208) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DSPP | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DSPP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSPP |
|
Pathways & Interactions
for DSPP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DSPP
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
DSPP for ontologies About GeneDecksing
|
Drugs & Compounds
for DSPP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DSPP for compounds About GeneDecksing
 Browse Tocris compounds for DSPP
1 HMDB Compound for DSPP About this table
10/143 Novoseek chemical compound relationships for DSPP gene (see all 143) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| scotchbond |
94.9 |
185 |
15575443 (3), 19683377 (3), 8600009 (3), 7499591 (3) (see all 99) |
| gluma |
93.4 |
165 |
15986959 (5), 7865421 (4), 11764114 (4), 1524756 (3) (see all 99) |
| syntac |
93 |
99 |
15851937 (2), 8600007 (2), 9545895 (2), 11572290 (2) (see all 69) |
| phosphoric acid |
91.2 |
505 |
12001244 (7), 11203785 (6), 1524738 (5), 17563100 (5) (see all 99) |
| scotchbond 2 |
90.1 |
52 |
1901813 (4), 1813345 (3), 1819937 (2), 1524740 (2) (see all 35) |
| dentsply |
86 |
45 |
15272658 (2), 1401449 (1), 16752698 (1), 14528776 (1) (see all 33) |
| calcium hydroxide |
86 |
136 |
14600695 (4), 15322647 (3), 12540209 (3), 17212082 (3) (see all 74) |
| copalite |
84 |
9 |
2367241 (1), 7993602 (1), 7576386 (1), 9002794 (1) (see all 7) |
| vivadent |
83.5 |
25 |
15810477 (2), 18800947 (1), 1291387 (1), 1288602 (1) (see all 16) |
| vitrebond |
82.7 |
30 |
2200818 (4), 1991864 (3), 15851937 (2), 1901813 (2) (see all 21) |
Search CenterWatch for drugs/clinical trials and news about DSPP
|
Transcripts
for DSPP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DSPP gene: NM_014208.3 Unigene Cluster for DSPP: Dentin sialophosphoprotein Hs.678914 Unigene Representative Sequence: NM_0142082 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000282478 ENST00000399271(uc003hqu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DSPP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DSPP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DSPP (NM_014208) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DSPP | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DSPP |
1 DOTS entry: DT.121243912 1 AceView cDNA sequence: NM_014208
GeneLoc Exon Structure
|
Expression
for DSPP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DSPP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTGAAAAT
About this image
See DSPP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DSPP
SOURCE GeneReport for Unigene cluster: Hs.678914
UniProtKB/Swiss-Prot: DSPP_HUMAN, Q9NZW4Tissue specificity: Expressed in teeth. DPP is synthesized by odontoblast and transiently expressed by pre-ameloblasts
SABiosciences Custom PCR Arrays for DSPP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DSPP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DSPP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSPP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSPP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSPP |
Orthologs
for DSPP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for DSPP gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ071618.12 |
-- |
67.6(n) |
|
BJ071618.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
stm1 |
starmaker |
35.62(n)
32.65(a) |
|
386700 NM_198817.2 NP_942112.2 |
mosquito
(Anopheles gambiae) |
Insecta |
AgaP_AGAP0108461 |
AGAP010846-PA |
32.42(n)
26.38(a) |
|
3291186 XM_564089.3 XP_564089.3 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
DDR481 |
Ddr48p |
39.83(n)
39.5(a) |
|
855210 NP_013897.1 |
ENSEMBL Gene Tree for DSPP (if available)
TreeFam Gene Tree for DSPP (if available) |
Paralogs
for DSPP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DSPP gene
- DMP12
DSPP for paralogs About GeneDecksing
|
Genomic Variants
for DSPP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DSPP (88529681 - 88538062 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DSPP
1 CNV: 98788
Human Gene Mutation Database (HGMD): DSPP
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DSPP |
|
Disorders
/ Diseases
for DSPP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DSPP for disorders About GeneDecksing
OMIM gene information: 125485
OMIM disorders: 125490 605594 125500 125420
UniProtKB/Swiss-Prot: DSPP_HUMAN, Q9NZW4
Defects in DSPP are the cause of deafness autosomal dominant type 39 with dentinogenesis imperfecta 1(DFNA39/DGI1) [MIM:605594]. Affected individuals present DGI1 associated with early onset progressive sensorineuralhigh-frequency hearing loss Defects in DSPP are the cause of dentinogenesis imperfecta type 1 (DGI1) [MIM:125490]; also known asdentinogenesis imperfecta Shields type 2 (DGI2). DGI1 is an autosomal dominant disorder in which both the primary andthe permanent teeth are affected. It occurs with an incidence of 1:8000 live births. The teeth are amber andopalescent, the pulp chamber being obliterated by abnormal dentin. The enamel, although unaffected, tends to fracture,which makes dentin undergo rapid attrition, leading to shortening of the teeth Defects in DSPP are a cause of dentinogenesis imperfecta Shields type 3 (DGI3) [MIM:125500]. Patients withDGI3 do not have stigmata of osteogenesis imperfecta. The finding that a single defects in the DSPP gene causes bothphenotypic patterns of DGI2 and DGI3 strongly supports the conclusion that these two disorders are not separatediseases but rather the phenotypic variation of a single genetic defect Defects in DSPP are the cause of dentin dysplasia type 2 (DTDP2) [MIM:125420]; also known as dentin dysplasiaShields type 2. DTDP2 is an autosomal dominant disorder in which mineralization of the dentine of the primary teeth isabnormal. On the basis of the phenotypic overlap between, and shared chromosomal location with DGI2 it has beenproposed that DTDP2 and DGI2 are allelic. From the results of recent studies, it is clear that different types ofmutations in DSPP lead to the two different phenotypes
20/85  diseases for DSPP (see all 85): About MalaCardsdentinogenesis imperfecta dentinogenesis imperfecta 1 tricho-dento-osseous syndrome deafness, autosomal dominant 36
deafness, autosomal dominant 36, with dentinogenesis ehlers-danlos syndrome dentinogenesis imperfecta shields type 3 dentin dysplasia, type ii
odontoma dentin dysplasia amelogenesis imperfecta root caries
dental pulp calcification osteogenesis imperfecta tooth resorption dental enamel hypoplasia
tooth erosion gastroesophageal reflux disease dental caries cleft lip/palate
7 diseases from the University of Copenhagen DISEASES database for DSPP:Dentinogenesis imperfecta Dentin dysplasia Vaginal discharge Dental pulp calcification
Dental enamel hypoplasia Endometritis Tooth agenesis 10/95 Novoseek disease relationships for DSPP gene (see all 95) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dentinogenesis imperfecta |
89.4 |
141 |
11116156 (3), 10371252 (3), 17686168 (2), 18797159 (2) (see all 65) |
| dentin dysplasia |
89.2 |
110 |
9493074 (7), 1785908 (4), 19417880 (4), 1891231 (3) (see all 48) |
| dentin sensitivity |
89.2 |
82 |
2285881 (4), 1508870 (3), 1650304 (3), 1819929 (3) (see all 43) |
| dgi-ii |
85 |
35 |
10765957 (4), 20146806 (2), 8006116 (2), 11175779 (2) (see all 14) |
| hereditary opalescent dentin |
81.7 |
19 |
19927739 (3), 19186872 (2), 9780905 (2), 15573663 (2) (see all 9) |
| teeth endodontically treated |
81.4 |
38 |
16399275 (2), 15318256 (2), 18021825 (2), 18718775 (2) (see all 30) |
| dgi-iii |
75.2 |
9 |
15690376 (3), 10371253 (1), 17452557 (1) |
| root caries |
74.2 |
23 |
8054192 (2), 10522203 (2), 14674495 (2), 10575804 (1) (see all 17) |
| collagen fibril |
73.1 |
90 |
15769538 (3), 15846504 (2), 16973251 (2), 9736372 (2) (see all 65) |
| pulpless teeth |
71.8 |
12 |
1402574 (4), 1432755 (2), 7853252 (1), 17655074 (1) (see all 5) |
Human Genome Epidemiology (HuGE) Navigator: DSPP (2 documents)
Export disorders for DSPP gene to outside databases
|
Publications
for DSPP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DSPP gene, integrated from 9 sources (see all 2073):
(articles sorted by number of sources associating them with DSPP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of a human dentin sialophosphoprotein gene. (PubMed id 10706475)1, 2, 9 Gu K.... Rutherford R.B. (2000)
- Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4. Dentin phosphoprotein DNA sequence determination. (PubMed id 8995371)1, 3, 9 MacDougall M....Gu T.T. (1997)
- DSPP mutation in dentinogenesis imperfecta Shields type II. (PubMed id 11175779)1, 2, 9 Zhang X.... Shen Y. (2001)
- Human dentin phosphophoryn nucleotide and amino acid sequence. (PubMed id 9879917)1, 2, 9 Gu K....Ritchie H.H. (1998)
- DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. (PubMed id 17033625)1, 2 Lorenz-Depiereux B.... Strom T.M. (2006)
- Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. (PubMed id 11175790)1, 2 Xiao S.... Kong X. (2001)
- Assignment of dentin sialophosphoprotein (DSPP) to the critical DGI2 locus on human chromosome 4 band q21.3 by in situ hybridization. (PubMed id 9533027)1, 3 MacDougall M....DuPont B.R. (1997)
- Dentin sialophosphoprotein (DSPP) is cleaved into its two natural dentin matrix products by three isoforms of bone morphogenetic pro tein-1 (BMP1). (PubMed id 20079836)1, 9 von Marschall Z. and Fisher L.W. (2010)
- Dentin phosphoprotein frameshift mutations in hereditary dentin disorders and their variation patterns in normal human population. (PubMed id 18456718)1, 9 Song Y.L....Bian Z. (2008)
- Dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis. (PubMed id 16014627)1, 9 Paine M.L....Snead M.L. (2005)
|
External Searches for DSPP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DSPP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DSPP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DSPP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DSPP gene:
Search GeneIP for patents involving DSPP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DSPP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DSPP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DSPP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DSPP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DSPP | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DSPP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DSPP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DSPP | | OriGene Custom Protein Services for DSPP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DSPP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DSPP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSPP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSPP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSPP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSPP |
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| | | | Search Tocris compounds for DSPP |
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 | | | DSPP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSPP |
|  |  |  |  | | | | Search ThermoFisher Antibodies for DSPP |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DSPP |
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