Aliases for DSPP Gene
External Ids for DSPP Gene
Previous Symbols for DSPP Gene
This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DSPP Gene
DSPP (Dentin Sialophosphoprotein) is a Protein Coding gene. Diseases associated with DSPP include dentinogenesis imperfecta, shields type ii and vaginal discharge. Among its related pathways are ERK Signaling and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and collagen binding.
UniProtKB/Swiss-Prot for DSPP Gene
DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals