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DSPP Gene

protein-coding   GIFtS: 53
GCID: GC04P088529

Dentin Sialophosphoprotein


(Previous symbols: DFNA39, DGI1)
  See DSPP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dentin Sialophosphoprotein1 2     DSP2
DFNA391 2 5     Dentin Phosphophoryn2
DGI11 2 5     Dentin Phosphoprotein2
DPP2 5     Dentin Phosphoryn2
DTDP22 5     Dentin Sialoprotein2
DMP32     

External Ids:    HGNC: 30541   Entrez Gene: 18342   Ensembl: ENSG000001525917   OMIM: 1254855   UniProtKB: Q9NZW43   

Export aliases for DSPP gene to outside databases

Previous GC identifers: GC04P088687 GC04P088831 GC04P088988 GC04P088886 GC04P084275


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DSPP Gene:
This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is
secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is
thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated
with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an
autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DSPP Gene:
DSPP (dentin sialophosphoprotein) is a protein-coding gene. Diseases associated with DSPP include tooth erosion, and dentin caries. GO annotations related to this gene include collagen binding and calcium ion binding.

UniProtKB/Swiss-Prot: DSPP_HUMAN, Q9NZW4
Function: DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate
initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals

Gene Wiki entry for DSPP (Dentin sialophosphoprotein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DSPP gene promoter:
         c-Fos   S8   AP-1   Pax-6   ATF-2   c-Jun   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDSPP promoter sequence
   Search Chromatin IP Primers for DSPP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DSPP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.3   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21.3

DSPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSPP gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088529:  view genomic region     (about GC identifiers)

Start:
88,529,681 bp from pter      End:
88,538,062 bp from pter
Size:
8,382 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DSPP_HUMAN, Q9NZW4 (See protein sequence)
Recommended Name: Dentin sialophosphoprotein precursor  
Size: 1301 amino acids; 131151 Da
Subunit: Interacts with FBLN7 (By similarity)
Secondary accessions: A8MUI0 O95815

Explore the universe of human proteins at neXtProt for DSPP: NX_Q9NZW4

Explore proteomics data for DSPP at MOPED

Post-translational modifications: 

  • DSP is glycosylated1
  • Glycosylation2 at Asn41, Asn49, Asn81, Asn130, Asn150, Asn190, Asn191, Asn209, Asn222, Asn275,
                                 Asn336, Asn387
  • Modification sites at PhosphoSitePlus

  • See DSPP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055023.2  
    ENSEMBL proteins: 
     ENSP00000282478   ENSP00000382213  
    Reactome Protein details: Q9NZW4

    DSPP Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for DSPP
    Cloud-Clone Corp. CLIAs for DSPP
    Search eBioscience for ELISAs for DSPP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9NZW4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DSPP_HUMAN, Q9NZW4
    Function: DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate
    initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals

         Genatlas biochemistry entry for DSPP:
    dentin sialophosphoprotein,precursor of dentin sialoprotein (DSP) and dentin phosphoprotein,non collagenous
    components of the dentin extra-cellular matrix,tooth specific,encoded by a bicistronic transcript

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS8995371
    GO:0005509calcium ion binding TAS9879917
    GO:0005518collagen binding TAS9879917
         
    Find genes that share ontologies with DSPP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DSPP:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dspp):
     craniofacial 

    Find genes that share phenotypes with DSPP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DSPP
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DSPP

    miRNA
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    miRTarBase miRNAs that target DSPP:
    hsa-mir-34a-5p (MIRT025251), hsa-mir-16-5p (MIRT031374), hsa-let-7b-5p (MIRT001637), hsa-mir-186-5p (MIRT045149), hsa-mir-9-5p (MIRT021319), hsa-let-7e-5p (MIRT051650)

    Block miRNA regulation of human, mouse, rat DSPP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DSPP:
    hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidDSPP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DSPP_HUMAN, Q9NZW4: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--

    Find genes that share ontologies with DSPP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DSPP About    
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    2ECM proteoglycans
    ECM proteoglycans


    Find genes that share SuperPaths with DSPP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DSPP
        ILK Signaling

    1 Reactome Pathway for DSPP
        ECM proteoglycans


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DSPP
    Interactions:

        GeneGlobe Interaction Network for DSPP

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8995371
    GO:0001503ossification TAS9879917
    GO:0007275multicellular organismal development TAS8995371
    GO:0030198extracellular matrix organization TAS--
    GO:0031214biomineral tissue development IEA--

    Find genes that share ontologies with DSPP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DSPP

    1 HMDB Compound for DSPP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for DSPP gene (see all 143)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scotchbond 94.9 185 15575443 (3), 19683377 (3), 8600009 (3), 7499591 (3) (see all 99)
    gluma 93.4 165 15986959 (5), 7865421 (4), 11764114 (4), 1524756 (3) (see all 99)
    syntac 93 99 15851937 (2), 8600007 (2), 9545895 (2), 11572290 (2) (see all 69)
    phosphoric acid 91.2 505 12001244 (7), 11203785 (6), 1524738 (5), 17563100 (5) (see all 99)
    scotchbond 2 90.1 52 1901813 (4), 1813345 (3), 1819937 (2), 1524740 (2) (see all 35)
    dentsply 86 45 15272658 (2), 1401449 (1), 16752698 (1), 14528776 (1) (see all 33)
    calcium hydroxide 86 136 14600695 (4), 15322647 (3), 12540209 (3), 17212082 (3) (see all 74)
    copalite 84 9 2367241 (1), 7993602 (1), 7576386 (1), 9002794 (1) (see all 7)
    vivadent 83.5 25 15810477 (2), 18800947 (1), 1291387 (1), 1288602 (1) (see all 16)
    vitrebond 82.7 30 2200818 (4), 1991864 (3), 15851937 (2), 1901813 (2) (see all 21)



    Find genes that share compounds with DSPP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DSPP gene: 
    NM_014208.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282478 ENST00000399271(uc003hqu.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat DSPP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DSPP:
    hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidDSPP 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DSPP
      QuantiFast Probe-based Assays in human, mouse, rat DSPP

    1 AceView cDNA sequence:

    NM_014208 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DSPP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGAAAAT
    DSPP Expression
    About this image


    DSPP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 7 entries
             Odontoblasts Dentin
             Dentin
             Odontoblast-like cells
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Mesenchymal Stem Cells
             Dental Pulp Stem Cells Dental Pulp
    DSPP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DSPP Protein Expression

    UniProtKB/Swiss-Prot: DSPP_HUMAN, Q9NZW4
    Tissue specificity: Expressed in teeth. DPP is synthesized by odontoblast and transiently expressed by
    pre-ameloblasts

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSPP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DSPP gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dspp5 dentin sialophosphoprotein   --   5 (50.59 cM) 104170712 
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ071618.12   -- 67.6(n)    BJ071618.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii BX299541.22   -- 80.02(n)    BX299541.2 


    ENSEMBL Gene Tree for DSPP (if available)
    TreeFam Gene Tree for DSPP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DSPP (see all 409)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360944641,2,,4
    C,FDentinogenesis imperfecta, Shields type 2 (DGI2)4 pathogenic188341850(+) GAGGAA/TGGCAA 2 R W mis112Minor allele frequency- T:0.08EU NS NA WA CSA EA 2440
    VAR_0702534
    Dentinogenesis imperfecta, Shields type 2 (DGI2)4--see VAR_0702532 V D mis40--------
    VAR_0702524
    Dentinogenesis imperfecta, Shields type 3 (DGI3)4--see VAR_0702522 P L mis40--------
    rs1119072641,2
    C,F--88336065(+) ATTTCC/TCTCAT 1 -- us2k12Minor allele frequency- T:0.06WA 120
    rs758079671,2
    C,F--88336072(+) TCATTA/TGTCTG 1 -- us2k11Minor allele frequency- T:0.15EA 120
    rs1911942281,2
    --88336292(+) TTAGTA/GCTATA 1 -- us2k10--------
    rs1502121761,2
    --88336327(+) GTGACA/TTCCCA 1 -- us2k10--------
    rs1834968671,2
    --88336374(+) CCCATA/TTATTT 1 -- us2k10--------
    rs1128150261,2
    C,F--88336453(+) ACTTGC/GGGTTT 1 -- us2k13Minor allele frequency- G:0.04CSA WA NA 240
    rs1883445971,2
    --88336513(+) TAAACA/CTAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DSPP (88529681 - 88538062 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DSPP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2581729CNV Deletion19546169
    esv2727947CNV Deletion23290073
    esv2727945CNV Deletion23290073
    esv2727946CNV Deletion23290073

    Human Gene Mutation Database (HGMD): DSPP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DSPP
    DNA2.0 Custom Variant and Variant Library Synthesis for DSPP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 125485   
    OMIM disorders: 125490  605594  125500  125420  
    UniProtKB/Swiss-Prot: DSPP_HUMAN, Q9NZW4
  • Deafness, autosomal dominant, 39, with dentinogenesis imperfecta 1 (DFNA39/DGI1) [MIM:605594]: A disorder
    characterized by the association of progressive sensorineural high-frequency hearing loss with dentinogenesis
    imperfecta. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Dentinogenesis imperfecta, Shields type 2 (DGI2) [MIM:125490]: A form of dentinogenesis imperfecta, an
    autosomal dominant dentin disorder characterized by amber-brown, opalescent teeth that fracture and shed their
    enamel during mastication, thereby exposing the dentin to rapid wear. Radiographically, the crown appears bulbous
    and pulpal obliteration is common. The pulp chambers are initially larger than normal prior and immediately after
    tooth eruption, and then progressively close down to become almost obliterated by abnormal dentin formation.
    Roots are short and thin. Both primary and permanent teeth are affected. DGI2 is not associated with osteogenesis
    imperfecta. Note=The disease is caused by mutations affecting the gene represented in this entry. DSPP defects
    causing dentin abnormalities act in a dominant negative manner and include missense, splice-site, frameshift
    mutations. 5' frameshift mutations cause dentin dysplasia while frameshift mutations at the 3' end cause the more
    severe dentinogenesis imperfecta phenotype (PubMed:18521831 and PubMed:22392858)
  • Dentinogenesis imperfecta, Shields type 3 (DGI3) [MIM:125500]: A form of dentinogenesis imperfecta, an
    autosomal dominant dentin disorder characterized by amber-brown, opalescent teeth that fracture and shed their
    enamel during mastication, thereby exposing the dentin to rapid wear. Radiographically, the crown appears bulbous
    and pulpal obliteration is common. The pulp chambers are initially larger than normal prior and immediately after
    tooth eruption, and then progressively close down to become almost obliterated by abnormal dentin formation.
    Roots are short and thin. Both primary and permanent teeth are affected. DGI3 teeth typically manifest multiple
    periapical radiolucencies. DGI3 is not associated with osteogenesis imperfecta. Note=The disease is caused by
    mutations affecting the gene represented in this entry. DSPP defects causing dentin abnormalities act in a
    dominant negative manner and include missense, splice-site, frameshift mutations. 5' frameshift mutations cause
    dentin dysplasia while frameshift mutations at the 3' end cause the more severe dentinogenesis imperfecta
    phenotype (PubMed:18521831 and PubMed:22392858)
  • Dentin dysplasia 2 (DTDP2) [MIM:125420]: A dental defect in which the deciduous teeth are opalescent. The
    permanent teeth are of normal shape, form, and color in most cases. The root length is normal. On radiographs,
    the pulp chambers of permanent teeth are obliterated, have a thistle-tube deformity and contain pulp stones.
    Note=The disease is caused by mutations affecting the gene represented in this entry. DSPP defects causing dentin
    abnormalities act in a dominant negative manner and include missense, splice-site, frameshift mutations. 5'
    frameshift mutations cause dentin dysplasia while frameshift mutations at the 3' end cause the more severe
    dentinogenesis imperfecta phenotype (PubMed:18521831, PubMed:22392858)

  • Selected diseases for DSPP (see all 29):    
    About MalaCards
    tooth erosion    dentin caries    dental pulp calcification    hypercementosis
    tooth resorption    pulp degeneration    dentinogenesis imperfecta 1    gingival recession
    dentinogenesis imperfecta    dentinogenesis imperfecta shields type 3    dentin dysplasia, type ii    dentin sensitivity
    dentin dysplasia    regional odontodysplasia    dental caries    deafness, autosomal dominant 36, with dentinogenesis
    root caries    odontoma    vaginal discharge    ankylosis

    7 diseases from the University of Copenhagen DISEASES database for DSPP:
    Dentinogenesis imperfecta     Dentin dysplasia     Vaginal discharge     Dental pulp calcification
    Dental enamel hypoplasia     Endometritis     Tooth agenesis

    Find genes that share disorders with DSPP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DSPP gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dentinogenesis imperfecta 89.4 141 11116156 (3), 10371252 (3), 17686168 (2), 18797159 (2) (see all 65)
    dentin dysplasia 89.2 110 9493074 (7), 1785908 (4), 19417880 (4), 1891231 (3) (see all 48)
    dentin sensitivity 89.2 82 2285881 (4), 1508870 (3), 1650304 (3), 1819929 (3) (see all 43)
    dgi-ii 85 35 10765957 (4), 20146806 (2), 8006116 (2), 11175779 (2) (see all 14)
    hereditary opalescent dentin 81.7 19 19927739 (3), 19186872 (2), 9780905 (2), 15573663 (2) (see all 9)
    teeth endodontically treated 81.4 38 16399275 (2), 15318256 (2), 18021825 (2), 18718775 (2) (see all 30)
    dgi-iii 75.2 9 15690376 (3), 10371253 (1), 17452557 (1)
    root caries 74.2 23 8054192 (2), 10522203 (2), 14674495 (2), 10575804 (1) (see all 17)
    collagen fibril 73.1 90 15769538 (3), 15846504 (2), 16973251 (2), 9736372 (2) (see all 65)
    pulpless teeth 71.8 12 1402574 (4), 1432755 (2), 7853252 (1), 17655074 (1) (see all 5)

    Genetic Association Database (GAD): DSPP
    Human Genome Epidemiology (HuGE) Navigator: DSPP (2 documents)

    Export disorders for DSPP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DSPP gene, integrated from 10 sources (see all 2078):
    (articles sorted by number of sources associating them with DSPP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a human dentin sialophosphoprotein gene. (PubMed id 10706475)1, 2, 9 Gu K.... Rutherford R.B. (Eur. J. Oral Sci. 2000)
    2. Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4. Dentin phosphoprotein DNA sequence determination. (PubMed id 8995371)1, 3, 9 MacDougall M....Gu T.T. (J. Biol. Chem. 1997)
    3. DSPP mutation in dentinogenesis imperfecta Shields type II. (PubMed id 11175779)1, 2, 9 Zhang X.... Shen Y. (Nat. Genet. 2001)
    4. A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP gene. (PubMed id 18521831)1, 2, 9 McKnight D.A.... Fisher L.W. (Hum. Mutat. 2008)
    5. Human dentin phosphophoryn nucleotide and amino acid sequence. (PubMed id 9879917)1, 2, 9 Gu K....Ritchie H.H. (Eur. J. Oral Sci. 1998)
    6. A DSPP mutation causing dentinogenesis imperfecta and characterization of the mutational effect. (PubMed id 23509818)1, 2 Lee S.K....Kim J.W. (Biomed Res Int 2013)
    7. Rough endoplasmic reticulum trafficking errors by different classes of mutant dentin sialophosphoprotein (DSPP) cause dominant negative effects in both dentinogenesis imperfecta and dentin dysplasia by entrapping normal DSPP. (PubMed id 22392858)1, 2 von Marschall Z....Fisher L.W. (J. Bone Miner. Res. 2012)
    8. Identification of the DSPP mutation in a new kindred and phenotype-genotype correlation. (PubMed id 21029264)1, 2 Lee S.K....Kim J.W. (Oral Dis 2011)
    9. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    10. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1834 HGNC: 3054 AceView: DSPP Ensembl:ENSG00000152591 euGenes: HUgn1834
    ECgene: DSPP H-InvDB: DSPP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DSPP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DSPP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DSPP gene:
    Search GeneIP for patents involving DSPP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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