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DSN1 Gene

protein-coding   GIFtS: 52
GCID: GC20M035380

DSN1, MIS12 Kinetochore Complex Component

(Previous names: chromosome 20 open reading frame 172, DSN1, MIND kinetochore...)
(Previous symbol: C20orf172)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DSN1, MIS12 Kinetochore Complex Component1 2     KNL32
C20orf1721 2 3     dJ469A13.22
MIS132 3     DSN1, MIND Kinetochore Complex Component, Homolog2
Chromosome 20 Open Reading Frame 1721     hKNL-32
DSN1, MIND Kinetochore Complex Component, Homolog (S. Cerevisiae)1     Kinetochore Null 3 Homolog2
Kinetochore Null 3 Homolog (C. Elegans)1     Kinetochore-Associated Protein DSN1 Homolog2

External Ids:    HGNC: 161651   Entrez Gene: 799802   Ensembl: ENSG000001496367   OMIM: 6091755   UniProtKB: Q9H4103   

Export aliases for DSN1 gene to outside databases

Previous GC identifers: GC20M034815 GC20M032116


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DSN1 Gene:
This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere
complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Feb 2009)

GeneCards Summary for DSN1 Gene:
DSN1 (DSN1, MIS12 kinetochore complex component) is a protein-coding gene. Diseases associated with DSN1 include tonsillitis, and thyroiditis.

UniProtKB/Swiss-Prot: DSN1_HUMAN, Q9H410
Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and
kinetochore formation during mitosis

Gene Wiki entry for DSN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DSN1 gene promoter:
         GR   AREB6   GR-beta   GR-alpha   HNF-3beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDSN1 promoter sequence
   Search Chromatin IP Primers for DSN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DSN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

DSN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSN1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M035380:  view genomic region     (about GC identifiers)

Start:
35,380,194 bp from pter      End:
35,402,230 bp from pter
Size:
22,037 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DSN1_HUMAN, Q9H410 (See protein sequence)
Recommended Name: Kinetochore-associated protein DSN1 homolog  
Size: 356 amino acids; 40067 Da
Subunit: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with CASC5, CBX3
and CBX5
Sequence caution: Sequence=BAB14564.1; Type=Frameshift; Positions=277;
Secondary accessions: B4DWT2 E1P5U9 Q5JW55 Q5JW56 Q9H8P4
Alternative splicing: 4 isoforms:  Q9H410-1   Q9H410-2   Q9H410-4   Q9H410-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DSN1: NX_Q9H410

Explore proteomics data for DSN1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys132, Lys157, Lys217
  • Modification sites at PhosphoSitePlus

  • See DSN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001138787.1  NP_001138788.1  NP_001138789.1  NP_001138790.1  NP_079194.3  

    ENSEMBL proteins: 
     ENSP00000362845   ENSP00000404463   ENSP00000362855   ENSP00000362839   ENSP00000395760  
     ENSP00000399654   ENSP00000389810   ENSP00000362850  
    Reactome Protein details: Q9H410

    DSN1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for DSN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013218 Dsn1/Mis13

    Graphical View of Domain Structure for InterPro Entry Q9H410

    ProtoNet protein and cluster: Q9H410


    DSN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DSN1_HUMAN, Q9H410
    Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and
    kinetochore formation during mitosis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15502821
         
    DSN1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DSN1:
     Decreased viability of wild-ty  Increased G1 DNA content 

    Animal Models:
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DSN1

    miRNA
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    miRTarBase miRNAs that target DSN1:
    hsa-mir-193b-3p (MIRT016359), hsa-mir-192-5p (MIRT026495), hsa-mir-215-5p (MIRT024556)

    Block miRNA regulation of human, mouse, rat DSN1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate DSN1:
    hsa-miR-607 hsa-miR-186 hsa-miR-590-3p hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidDSN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DSN1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 5): DSN1 (NM_001145317)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSN1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DSN1_HUMAN, Q9H410: Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000444MIS12/MIND type complex IDA16585270
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    DSN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DSN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for DSN1
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids



    DSN1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DSN1
    Interactions:

        Search GeneGlobe Interaction Network for DSN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DSN1 (Q9H4102, 3 ENSP000003628504) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R3Q925692, 3MINT-8266205 I2D: score=2 
    AIMP2Q131552, 3, ENSP000002230294MINT-8258871 I2D: score=2 STRING: ENSP00000223029
    MIS12Q9H0813, ENSP000003705574I2D: score=4 STRING: ENSP00000370557
    ZWINTO952293, ENSP000003630554I2D: score=4 STRING: ENSP00000363055
    CASC5Q8NG313, ENSP000003354634I2D: score=2 STRING: ENSP00000335463
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation IEA--
    GO:0007067mitosis IEA--
    GO:0051301cell division ----

    DSN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DSN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DSN1 gene (5 alternative transcripts): 
    NM_001145315.1  NM_001145316.1  NM_001145317.1  NM_001145318.1  NM_024918.3  

    Unigene Cluster for DSN1:

    DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
    Hs.632268  [show with all ESTs]
    Unigene Representative Sequence: NM_001145316
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373740 ENST00000448110(uc002xgc.3) ENST00000473615 ENST00000480153(uc002xgb.3)
    ENST00000373750(uc002xga.3) ENST00000373734(uc010zvs.2) ENST00000492703
    ENST00000438549 ENST00000447406 ENST00000426836(uc010gfr.3 uc002xfy.4)
    ENST00000373745(uc002xfz.3)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate DSN1:
    hsa-miR-607 hsa-miR-186 hsa-miR-590-3p hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidDSN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DSN1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): DSN1 (NM_001145317)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSN1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DSN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DSN1
      QuantiTect SYBR Green Assays in human, mouse, rat DSN1
      QuantiFast Probe-based Assays in human, mouse, rat DSN1

    Additional mRNA sequence: 

    AK023408.1 AK093031.1 AK290738.1 AK301671.1 AK301840.1 BC026011.1 BC035821.1 BC058899.1 

    10 DOTS entries:

    DT.101983663  DT.100724334  DT.423104  DT.91716579  DT.97842569  DT.91716567  DT.99994506  DT.99989772 
    DT.92414125  DT.95082253 

    Selected AceView cDNA sequences (see all 111):

    BE350682 AW470067 CA413280 BQ227175 BC058899 CK000307 BQ646799 CR594821 
    AI383031 AL521561 BG574317 BQ057154 BF792421 CR593336 BC035821 BU629093 
    BP368904 AK093031 BG122940 BM561637 AI378990 AX747868 BX447143 BQ890302 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DSN1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:                          -     -                                                                                             
    SP2:                          -     -                                                                                             
    SP3:                                -                                                                                             
    SP4:                          -     -                                                                                             
    SP5:                          -     -                                   -                                                         


    ECgene alternative splicing isoforms for DSN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DSN1 expression in normal human tissues (normalized intensities)      DSN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAGAAAGG
    DSN1 Expression
    About this image


    DSN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    DSN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DSN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632268
        Custom PCR Arrays for DSN1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DSN1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dsn11 , 5 DSN1, MIND kinetochore complex component, homolog (S. more1, 5 79.81(n)1
    71.59(a)1
      2 (77.89 cM)5
    669341  NM_025853.31  NP_080129.21 
     1569952655 
    chicken
    (Gallus gallus)
    Aves DSN11 DSN1, MIND kinetochore complex component, homolog (S. more 58.83(n)
    50.2(a)
      426088  NM_001044660.1  NP_001038125.1 
    lizard
    (Anolis carolinensis)
    Reptilia DSN16
    DSN1, MIS12 kinetochore complex component
    42(a)
    1 ↔ 1
    GL343198.1(4229522-4251015)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004879011 kinetochore-associated protein DSN1 homolog 51.2(n)
    43.17(a)
      100487901  XM_002940567.2  XP_002940613.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000029161 kinetochore-associated protein DSN1 homolog 44.16(n)
    29.11(a)
      100002916  XM_001923613.3  XP_001923648.1 


    ENSEMBL Gene Tree for DSN1 (if available)
    TreeFam Gene Tree for DSN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DSN1 gene

    DSN1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DSN1
    PGOHUM00000236794


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DSN1 (see all 468)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61020791,2
    C,F,H--35379741(+) ataccC/Tggcta 5 -- ds50017Minor allele frequency- T:0.02NS NA WA 1024
    rs12752611,2
    F--35379833(+) ccaaaG/Ctgctg 5 -- ds50012Minor allele frequency- C:0.00NA 4
    rs597657761,2
    C--35379888(+) TTTTTTTTTTTT 
    TTTTTT
    /-
    GAGAC
    5 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1464830931,2
    --35379934(+) CACGAC/TCTCGG 5 -- ds50010--------
    rs1867759561,2
    --35379982(+) TCCTGC/TCTCAC 5 -- ds50010--------
    rs1133398271,2
    C,F--35380017(+) ACACCG/ACCACG 5 -- ds50011Minor allele frequency- A:0.50NA 2
    rs123738571,2
    C--35380050(+) tagtaG/Aagaca 5 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1501606591,2
    C--35380288(+) CTTTCC/TTGTCA 5 -- ut310--------
    rs114734161,2
    C--35380307(+) GATTT-/AGGAGGTC 5 -- cds10--------
    rs12752621,2
    C,F,H--35380383(+) TCAAAT/CTGAAC 5 -- ut318Minor allele frequency- C:0.04MN NS NA WA 1096

    HapMap Linkage Disequilibrium report for DSN1 (35380194 - 35402230 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DSN1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DSN1
    DNA2.0 Custom Variant and Variant Library Synthesis for DSN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609175    OMIM disorders: --

    3 diseases for DSN1:    About MalaCards
    tonsillitis    thyroiditis    prostatitis


    DSN1 for disorders           About GeneDecksing


    Export disorders for DSN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DSN1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with DSN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. (PubMed id 16585270)1, 2, 3 Kline S.L.... Desai A. (J. Cell Biol. 2006)
    2. The MIS12 complex is a protein interaction hub for outer kinetochore assembly. (PubMed id 20819937)1, 3 Petrovic A....Musacchio A. (J. Cell Biol. 2010)
    3. Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. (PubMed id 17981135)1, 2 Kiyomitsu T.... Yanagida M. (Dev. Cell 2007)
    4. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. (PubMed id 15502821)1, 2 Obuse C....Yanagida M. (Nat. Cell Biol. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment. (PubMed id 22869522)1 Liu X.S....Liu X. (Mol. Cell. Biol. 2012)
    10. Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. (PubMed id 22371557)1 Chan Y.W....Santamaria A. (J. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79980 HGNC: 16165 AceView: C20orf172 Ensembl:ENSG00000149636 euGenes: HUgn79980
    ECgene: DSN1 H-InvDB: DSN1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DSN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DSN1 gene:
    Search GeneIP for patents involving DSN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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