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Aliases for DSN1 Gene

Aliases for DSN1 Gene

  • DSN1 Homolog, MIS12 Kinetochore Complex Component 2 3 5
  • C20orf172 3 4
  • MIS13 3 4
  • DSN1, MIND Kinetochore Complex Component, Homolog (S. Cerevisiae) 2
  • DSN1, MIND Kinetochore Complex Component, Homolog 3
  • DSN1, MIS12 Kinetochore Complex Component 3
  • Kinetochore Null 3 Homolog (C. Elegans) 2
  • Chromosome 20 Open Reading Frame 172 2
  • Kinetochore Null 3 Homolog 3
  • DJ469A13.2 3
  • HKNL-3 3
  • KNL3 3

External Ids for DSN1 Gene

Previous HGNC Symbols for DSN1 Gene

  • C20orf172

Previous GeneCards Identifiers for DSN1 Gene

  • GC20M034815
  • GC20M035380
  • GC20M032116

Summaries for DSN1 Gene

Entrez Gene Summary for DSN1 Gene

  • This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

GeneCards Summary for DSN1 Gene

DSN1 (DSN1 Homolog, MIS12 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by Rho GTPases.

UniProtKB/Swiss-Prot for DSN1 Gene

  • Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

Gene Wiki entry for DSN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSN1 Gene

Genomics for DSN1 Gene

Regulatory Elements for DSN1 Gene

Enhancers for DSN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DSN1 on UCSC Golden Path with GeneCards custom track

Promoters for DSN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DSN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DSN1 Gene

36,751,791 bp from pter
36,773,827 bp from pter
22,037 bases
Minus strand

Genomic View for DSN1 Gene

Genes around DSN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DSN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DSN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSN1 Gene

Proteins for DSN1 Gene

  • Protein details for DSN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinetochore-associated protein DSN1 homolog
    Protein Accession:
    Secondary Accessions:
    • B4DWT2
    • E1P5U9
    • Q5JW55
    • Q5JW56
    • Q9H8P4

    Protein attributes for DSN1 Gene

    356 amino acids
    Molecular mass:
    40067 Da
    Quaternary structure:
    • Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with CASC5, CBX3 and CBX5. Interacts with KNSTRN.
    • Sequence=BAB14564.1; Type=Frameshift; Positions=277; Evidence={ECO:0000305};

    Alternative splice isoforms for DSN1 Gene


neXtProt entry for DSN1 Gene

Proteomics data for DSN1 Gene at MOPED

Post-translational modifications for DSN1 Gene

  • Ubiquitination at Lys 157 and Lys 217
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DSN1

No data available for DME Specific Peptides for DSN1 Gene

Domains & Families for DSN1 Gene

Protein Domains for DSN1 Gene


Suggested Antigen Peptide Sequences for DSN1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DSN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DSN1 Gene

Function for DSN1 Gene

Molecular function for DSN1 Gene

UniProtKB/Swiss-Prot Function:
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
genes like me logo Genes that share phenotypes with DSN1: view

Animal Model Products

miRNA for DSN1 Gene

miRTarBase miRNAs that target DSN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DSN1 Gene

Localization for DSN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DSN1 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore. {ECO:0000269 PubMed:15502821, ECO:0000269 PubMed:16585270}.

Subcellular locations from

Jensen Localization Image for DSN1 Gene COMPARTMENTS Subcellular localization image for DSN1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DSN1 Gene

Pathways & Interactions for DSN1 Gene

genes like me logo Genes that share pathways with DSN1: view

Pathways by source for DSN1 Gene

Interacting Proteins for DSN1 Gene

SIGNOR curated interactions for DSN1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DSN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with DSN1: view

Drugs & Compounds for DSN1 Gene

No Compound Related Data Available

Transcripts for DSN1 Gene

Unigene Clusters for DSN1 Gene

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DSN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - - -
SP9: - - -

Relevant External Links for DSN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DSN1 Gene

mRNA expression in normal human tissues for DSN1 Gene

Protein differential expression in normal tissues from HIPED for DSN1 Gene

This gene is overexpressed in Breast (18.3), Peripheral blood mononuclear cells (15.0), and Retina (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DSN1 Gene

SOURCE GeneReport for Unigene cluster for DSN1 Gene Hs.632268

genes like me logo Genes that share expression patterns with DSN1: view

Protein tissue co-expression partners for DSN1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DSN1 Gene

Orthologs for DSN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DSN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DSN1 35
  • 85.09 (n)
  • 78.35 (a)
DSN1 36
  • 77 (a)
(Canis familiaris)
Mammalia DSN1 35
  • 86.82 (n)
  • 80.23 (a)
DSN1 36
  • 57 (a)
(Mus musculus)
Mammalia Dsn1 35
  • 79.81 (n)
  • 71.59 (a)
Dsn1 16
Dsn1 36
  • 71 (a)
(Pan troglodytes)
Mammalia DSN1 35
  • 96.94 (n)
  • 97.03 (a)
DSN1 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Dsn1 35
  • 80.29 (n)
  • 72.06 (a)
(Monodelphis domestica)
Mammalia DSN1 36
  • 59 (a)
(Gallus gallus)
Aves DSN1 35
  • 58.83 (n)
  • 50.2 (a)
DSN1 36
  • 39 (a)
(Anolis carolinensis)
Reptilia DSN1 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487901 35
  • 51.2 (n)
  • 43.17 (a)
(Danio rerio)
Actinopterygii LOC100002916 35
  • 44.16 (n)
  • 29.11 (a)
DSN1 36
  • 24 (a)
Species with no ortholog for DSN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DSN1 Gene

Gene Tree for DSN1 (if available)
Gene Tree for DSN1 (if available)

Paralogs for DSN1 Gene Pseudogenes for DSN1 Gene

genes like me logo Genes that share paralogs with DSN1: view

No data available for Paralogs for DSN1 Gene

Variants for DSN1 Gene

Sequence variations from dbSNP and Humsavar for DSN1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1275261 -- 36,751,430(+) ccaaa(C/G)tgctg downstream-variant-500B
rs1275262 -- 36,751,980(+) TCAAA(C/T)TGAAC utr-variant-3-prime
rs1275263 -- 36,753,195(+) aaaaa(A/C)aatta intron-variant
rs3810505 -- 36,774,227(+) GTGGA(C/G)TGGAG upstream-variant-2KB
rs2425273 -- 36,755,986(+) TGTTT(G/T)TTTTT intron-variant

Variation tolerance for DSN1 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DSN1 Gene

Disorders for DSN1 Gene

Relevant External Links for DSN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DSN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DSN1 Gene

Publications for DSN1 Gene

  1. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. (PMID: 16585270) Kline S.L. … Desai A. (J. Cell Biol. 2006) 2 3 4 67
  2. The MIS12 complex is a protein interaction hub for outer kinetochore assembly. (PMID: 20819937) Petrovic A. … Musacchio A. (J. Cell Biol. 2010) 2 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for DSN1 Gene

Sources for DSN1 Gene