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Aliases for DSN1 Gene

Aliases for DSN1 Gene

  • DSN1, MIS12 Kinetochore Complex Component 2 3
  • C20orf172 3 4
  • MIS13 3 4
  • DSN1, MIND Kinetochore Complex Component, Homolog (S. Cerevisiae) 2
  • DSN1, MIND Kinetochore Complex Component, Homolog 3
  • Kinetochore-Associated Protein DSN1 Homolog 3
  • Kinetochore Null 3 Homolog (C. Elegans) 2
  • Chromosome 20 Open Reading Frame 172 2
  • Kinetochore Null 3 Homolog 3
  • DJ469A13.2 3
  • HKNL-3 3
  • KNL3 3

External Ids for DSN1 Gene

Previous HGNC Symbols for DSN1 Gene

  • C20orf172

Previous GeneCards Identifiers for DSN1 Gene

  • GC20M034815
  • GC20M035380
  • GC20M032116

Summaries for DSN1 Gene

Entrez Gene Summary for DSN1 Gene

  • This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

GeneCards Summary for DSN1 Gene

DSN1 (DSN1, MIS12 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for DSN1 Gene

  • Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

Gene Wiki entry for DSN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSN1 Gene

Genomics for DSN1 Gene

Regulatory Elements for DSN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DSN1 Gene

36,751,791 bp from pter
36,774,175 bp from pter
22,385 bases
Minus strand

Genomic View for DSN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DSN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSN1 Gene

Proteins for DSN1 Gene

  • Protein details for DSN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinetochore-associated protein DSN1 homolog
    Protein Accession:
    Secondary Accessions:
    • B4DWT2
    • E1P5U9
    • Q5JW55
    • Q5JW56
    • Q9H8P4

    Protein attributes for DSN1 Gene

    356 amino acids
    Molecular mass:
    40067 Da
    Quaternary structure:
    • Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with CASC5, CBX3 and CBX5. Interacts with KNSTRN.
    • Sequence=BAB14564.1; Type=Frameshift; Positions=277; Evidence={ECO:0000305};

    Alternative splice isoforms for DSN1 Gene


neXtProt entry for DSN1 Gene

Proteomics data for DSN1 Gene at MOPED

Post-translational modifications for DSN1 Gene

  • Ubiquitination at Lys132, Lys157, and Lys217
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DSN1 Gene

Domains for DSN1 Gene

Protein Domains for DSN1 Gene


Suggested Antigen Peptide Sequences for DSN1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DSN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DSN1 Gene

Function for DSN1 Gene

Molecular function for DSN1 Gene

UniProtKB/Swiss-Prot Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

Gene Ontology (GO) - Molecular Function for DSN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15502821
genes like me logo Genes that share ontologies with DSN1: view

Phenotypes for DSN1 Gene

genes like me logo Genes that share phenotypes with DSN1: view

Animal Model Products

CRISPR Products

miRNA for DSN1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DSN1 Gene

Localization for DSN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DSN1 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore. {ECO:0000269 PubMed:15502821, ECO:0000269 PubMed:16585270}.

Subcellular locations from

Jensen Localization Image for DSN1 Gene COMPARTMENTS Subcellular localization image for DSN1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DSN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000444 MIS12/MIND type complex IDA 16585270
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DSN1: view

Pathways for DSN1 Gene

genes like me logo Genes that share pathways with DSN1: view

Pathways by source for DSN1 Gene

Interacting Proteins for DSN1 Gene

Gene Ontology (GO) - Biological Process for DSN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007059 chromosome segregation IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with DSN1: view

Transcripts for DSN1 Gene

Unigene Clusters for DSN1 Gene

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DSN1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DSN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DSN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - - -
SP9: - - -

Relevant External Links for DSN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DSN1 Gene

mRNA expression in normal human tissues for DSN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DSN1 Gene

SOURCE GeneReport for Unigene cluster for DSN1 Gene Hs.632268

genes like me logo Genes that share expressions with DSN1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DSN1 Gene

Orthologs for DSN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DSN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DSN1 35
  • 96.94 (n)
  • 97.03 (a)
DSN1 36
  • 95 (a)
(Bos Taurus)
Mammalia DSN1 35
  • 85.09 (n)
  • 78.35 (a)
DSN1 36
  • 77 (a)
(Canis familiaris)
Mammalia DSN1 35
  • 86.82 (n)
  • 80.23 (a)
DSN1 36
  • 57 (a)
(Mus musculus)
Mammalia Dsn1 35
  • 79.81 (n)
  • 71.59 (a)
Dsn1 16
Dsn1 36
  • 71 (a)
(Monodelphis domestica)
Mammalia DSN1 36
  • 59 (a)
(Rattus norvegicus)
Mammalia Dsn1 35
  • 80.29 (n)
  • 72.06 (a)
(Gallus gallus)
Aves DSN1 35
  • 58.83 (n)
  • 50.2 (a)
DSN1 36
  • 39 (a)
(Anolis carolinensis)
Reptilia DSN1 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487901 35
  • 51.2 (n)
  • 43.17 (a)
(Danio rerio)
Actinopterygii DSN1 36
  • 24 (a)
LOC100002916 35
  • 44.16 (n)
  • 29.11 (a)
Species with no ortholog for DSN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DSN1 Gene

Gene Tree for DSN1 (if available)
Gene Tree for DSN1 (if available)

Paralogs for DSN1 Gene Pseudogenes for DSN1 Gene

genes like me logo Genes that share paralogs with DSN1: view

No data available for Paralogs for DSN1 Gene

Variants for DSN1 Gene

Sequence variations from dbSNP and Humsavar for DSN1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1275261 -- 36,751,430(+) ccaaa(C/G)tgctg downstream-variant-500B
rs1275262 -- 36,751,980(+) TCAAA(C/T)TGAAC utr-variant-3-prime
rs1275263 -- 36,753,195(+) aaaaa(A/C)aatta intron-variant
rs2425273 -- 36,755,986(+) TGTTT(G/T)TTTTT intron-variant
rs2425274 -- 36,756,908(+) GGGGA(A/T)ATTTT intron-variant

Relevant External Links for DSN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DSN1 Gene

Disorders for DSN1 Gene

No disorders were found for DSN1 Gene.

No data available for UniProtKB/Swiss-Prot for DSN1 Gene

Publications for DSN1 Gene

  1. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. (PMID: 16585270) Kline S.L. … Desai A. (J. Cell Biol. 2006) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. (PMID: 15502821) Obuse C. … Yanagida M. (Nat. Cell Biol. 2004) 3 4

Products for DSN1 Gene

Sources for DSN1 Gene

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