Aliases for DSG4 Gene
External Ids for DSG4 Gene
Previous GeneCards Identifiers for DSG4 Gene
This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. [provided by RefSeq, May 2016]
GeneCards Summary for DSG4 Gene
DSG4 (Desmoglein 4) is a Protein Coding gene. Diseases associated with DSG4 include Hypotrichosis 6 and Monilethrix. Among its related pathways are Keratinization and Developmental Biology. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DSG3.
UniProtKB/Swiss-Prot for DSG4 Gene
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).