Aliases for DSG4 Gene
External Ids for DSG4 Gene
This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded protein is a transmembrane component in desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and potentially in other skin disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
GeneCards Summary for DSG4 Gene
DSG4 (Desmoglein 4) is a Protein Coding gene. Diseases associated with DSG4 include hypotrichosis and hypotrichosis 6. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH13.
UniProtKB/Swiss-Prot for DSG4 Gene
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).