Aliases for DSG3 Gene
External Ids for DSG3 Gene
Previous GeneCards Identifiers for DSG3 Gene
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016]
GeneCards Summary for DSG3 Gene
DSG3 (Desmoglein 3) is a Protein Coding gene. Diseases associated with DSG3 include Pemphigus and Pemphigus Vulgaris. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Apoptotic cleavage of cellular proteins. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DSG4.
UniProtKB/Swiss-Prot for DSG3 Gene
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.