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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DSG3 Gene

protein-coding   GIFtS: 59
GCID: GC18P029050

desmoglein 3

(Previous name: desmoglein 3 (pemphigus vulgaris antigen) )
 Explore 42 diseases affiliated with
DSG3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DSG3    

Aliases
for DSG3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Desmoglein 31 2     Desmoglein 3 (Pemphigus Vulgaris Antigen)1
CDHF61 2 3     130-KD Pemphigus Vulgaris Antigen2
Cadherin Family Member 62 3     Desmoglein-31
130 KDa Pemphigus Vulgaris Antigen2 3     Pemphigus Vulgaris Antigen2
PVA2 3     

External Ids:    HGNC: 30501   Entrez Gene: 18302   Ensembl: ENSG000001347577   OMIM: 1696155   UniProtKB: P329263   

Export aliases for DSG3 gene to outside databases

Previous GC identifers: GC18P028846 GC18P027279 GC18P027281 GC18P025884


Summaries
for DSG3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DSG3:
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a
calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three
desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule
superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been
identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: DSG3_HUMAN, P32926
Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and
intermediate filaments mediating cell-cell adhesion

Gene Wiki entry for DSG3 (Desmoglein 3)


Genomic Views
for DSG3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DSG3 gene promoter:
         STAT5B   HFH-3   STAT1   Sox5   NCX/Ncx   Lmo2   CUTL1   STAT1alpha   AREB6   FOXI1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DSG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DSG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.1   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.1

DSG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSG3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P029050:  view genomic region     (about GC identifiers)

Start:
 29,027,732 bp from pter      End:
 29,058,665 bp from pter
Size:
 30,934 bases      Orientation:
 plus strand

Proteins
for DSG3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DSG3_HUMAN, P32926 (See protein sequence)
Recommended Name: Desmoglein-3 precursor  
Size: 999 amino acids; 107533 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, desmosome (By
similarity)
Miscellaneous: Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the
result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3
Secondary accessions: A8K2V2

Explore the universe of human proteins at neXtProt for DSG3: NX_P32926

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P32926

    • DSG3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001935.2  
    ENSEMBL proteins: 
     ENSP00000257189  
    Reactome Protein details: P32926
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DSG3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0030057desmosome IEA--


    DSG3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DSG3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DSG3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR009123 Desmoglein
     IPR000233 Cadherin_cytoplasmic-dom
     IPR002126 Cadherin
     IPR015919 Cadherin-like
     IPR009122 Desmo_cadherin

    Graphical View of Domain Structure for InterPro Entry P32926

    ProtoNet protein and cluster: P32926

    3 Blocks protein families:
    IPB002126 Cadherin
    IPB009122 Desmosomal cadherin signature
    IPB009123 Desmoglein signature


    UniProtKB/Swiss-Prot: DSG3_HUMAN, P32926
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,
    imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 4 cadherin domains


    Function
    for DSG3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DSG3_HUMAN, P32926
    Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and
    intermediate filaments mediating cell-cell adhesion

         Genatlas biochemistry entry for DSG3:
    desmoglein 3 (desmosomal glycoprotein,cadherin superfamily of calcium dependent cell-adhesion molecule),pemphigus
    vulgaris and herpetiform pemphigus,autoantigen (130kDa),mostly expressed in stratified squamous epithelia,lower
    spinous layer,critical for development of the epidermis and physiologic terminal differentiation of keratinocytes

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DSG3
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate DSG3 (see all 25):
    hsa-let-7d hsa-miR-188-5p hsa-miR-29c hsa-miR-29a hsa-let-7c hsa-miR-374a hsa-let-7g hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: DSG3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DSG3 (see all 4)
    OriGene shRNA RFP: DSG3
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DSG3

    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--


    DSG3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DSG3:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Dsg3tm1Stan for DSG3
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dsg3):
     adipose tissue  cellular  craniofacial  digestive/alimentary  growth/size 
     hematopoietic system  immune system  integument  mortality/aging  vision/eye 

    DSG3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DSG3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic cleavage of cellular proteins
    		Apoptotic cleavage of cellular proteins1.00
    		Apoptotic execution phase0.73
    2Apoptotic cleavage of cell adhesion proteins
    		Apoptotic cleavage of cell adhesion proteins1.00
    3Ubiquitinated Orc1 is degraded by the proteasome
    		Apoptosis0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for DSG3
        Apoptotic cleavage of cell adhesion proteins
    Apoptotic execution phase
    Apoptotic cleavage of cellular proteins
    Apoptosis



    DSG3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DSG3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DSG3 (P329263 ENSP000002571894) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PKP3Q9Y4463, ENSP000003316784I2D: score=3 STRING: ENSP00000331678
    JUPP149233, ENSP000003111134I2D: score=2 STRING: ENSP00000311113
    CASP3P425743, ENSP000003110324I2D: score=1 STRING: ENSP00000311032
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007156homophilic cell adhesion IEA--


    DSG3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DSG3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DSG3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DSG3

    1 HMDB Compound for DSG3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    7 Novoseek chemical compound relationships for DSG3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ivig 57.7 7 16297153 (3), 18423257 (1), 19222460 (1), 18693160 (1)
    toxin a 39.4 2 11062541 (1), 15854034 (1)
    prednisolone 18.7 2 15942219 (1), 18410336 (1)
    serine 6.91 4 17101502 (1), 19348003 (1), 10427986 (1)
    calcium 0 23 18578707 (7), 19348003 (4), 2306347 (2), 7543549 (1) (see all 7)
    tyrosine 0 1 18434319 (1)
    acetylcholine 0 1 17377799 (1)

    Search CenterWatch for drugs/clinical trials and news about DSG3 

    Transcripts
    for DSG3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DSG3 gene: 
    NM_001944.2  

    Unigene Cluster for DSG3:

    Desmoglein 3
    Hs.1925  [show with all ESTs]
    Unigene Representative Sequence: NM_001944
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000257189(uc002kws.3 uc002kwt.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DSG3
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate DSG3 (see all 25):
    hsa-let-7d hsa-miR-188-5p hsa-miR-29c hsa-miR-29a hsa-let-7c hsa-miR-374a hsa-let-7g hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: DSG3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DSG3 (see all 4)
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    OriGene siRNA: DSG3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSG3
    Clone
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    GenScript: all cDNA clones in your preferred vector: DSG3 (NM_001944)
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    Primer
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    Additional cDNA sequence: 

    AK290367.1 BC063544.1 BC105997.1 M76482.1 

    3 DOTS entries:

    DT.103524  DT.40113974  DT.91750134 

    24/72 AceView cDNA sequences (see all 72):

    BP368530 BG679530 M76482 NM_001944 BX507120 BC063544 BX099718 AL603251 
    CB134600 BX953299 AI582245 U51696 AI813404 BX110234 BG742713 BX538327 
    BX477176 BG677707 AW873136 BG677389 BX642231 AW381250 AA045253 BX504828 

    GeneLoc Exon Structure


    Expression
    for DSG3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DSG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DSG3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungRespiratory BronchiolesBasal CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DSG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DSG3

    SOURCE GeneReport for Unigene cluster: Hs.1925

    UniProtKB/Swiss-Prot: DSG3_HUMAN, P32926
    Tissue specificity: Epidermis, tongue, tonsil, esophagus and carcinomas

        SABiosciences Expression via Pathway-Focused PCR Arrays including DSG3: 
              Lung Cancer in human mouse rat
              Adherens Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSG3

    Orthologs
    for DSG3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DSG3 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NHU4_CHICK6
    		 Uncharacterized protein
    		 39(a)
    		 1 → many
    		 2(109227240-109245549)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 40(a)
    		 1 → many
    		 GL343207.1(3859127-3883207)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch73-74h11.16
    FP236168.16
    (see all 3)    		 --
    		 33(a)
    27(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 20(16990224-17010459)
    2(2392229-2424395)


    ENSEMBL Gene Tree for DSG3 (if available)
    TreeFam Gene Tree for DSG3 (if available) 

    Paralogs
    for DSG3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DSG3 gene
    CDH42  CDH182  DSG42  CDH32  CDH102  CDH112  CDH12  CDH62  
    DSC22  CDH82  CDH202  CDH222  DSC12  CDH192  DSG12  CDH72  
    DSG22  CDH92  CDH122  CDH262  DSC32  CDH22  CDH242  CDH152  
    CDH52  
    6 SIMAP similar genes for DSG3 using alignment to 1 protein entry:     DSG3_HUMAN:
    DKFZp686P23184    DSG4    DSG1    DSG2    ME5    CDH1

    DSG3 for paralogs           About GeneDecksing



    Genomic Variants
    for DSG3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/757 NCBI SNPs in DSG3 are shown (see all 757)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1445157071,2
    		--29025736(+) TAGTGA/GGAACT 1 -- us2k10--------
    rs1841668101,2
    		--29025757(+) CACCAA/GATTTG 1 -- us2k10--------
    rs1899328191,2
    		--29025786(+) TCCTAA/GTGGAA 1 -- us2k10--------
    rs100483051,2
    		C,F,H,--29025949(+) CATACA/GGTCTC 1 -- us2k113Minor allele frequency- G:0.38NS EA NA WA CSA 784
    rs1914929271,2
    		--29025956(+) TCTCTA/GTCCAT 1 -- us2k10--------
    rs1843726141,2
    		--29026092(+) AAGAGC/TGGTAA 1 -- us2k10--------
    rs1391950831,2
    		--29026094(+) GAGTGG/TTAATG 1 -- us2k10--------
    rs578461041,2
    		C,F,--29026220(+) AAAACA/CAAATT 1 -- us2k13Minor allele frequency- C:0.16WA CSA 122
    rs80971881,2
    		C,--29026313(+) gctcaA/Cgcctg 1 -- us2k10--------
    rs286987821,2
    		C,F,--29026346(+) GAGGCA/GGGAGG 1 -- us2k15Minor allele frequency- G:0.26NA WA CSA 127

    HapMap Linkage Disequilibrium report for DSG3 (29027732 - 29058665 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for DSG3
         3 CNVs: 34481 1968 8856
         1 Indel: 10711

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    Disorders / Diseases
    for DSG3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DSG3 for disorders           About GeneDecksing

    OMIM gene information: 169615    OMIM disorders: --

    20/42 diseases for DSG3 (see all 42):    About MalaCards
    pemphigus vulgaris    pemphigus    multiple self healing squamous epithelioma    subcorneal pustular dermatosis
    hailey-hailey disease    epidermolysis bullosa acquisita    pemphigus foliaceus    dendritic cell sarcoma
    follicular dendritic cell sarcoma    lichen planus    inverted papilloma    epidermolysis bullosa
    castleman's disease    dermatitis herpetiformis    bullous pemphigoid    squamous cell carcinoma
    myasthenia gravis    bronchiolitis obliterans    keratoacanthoma    ritter's disease

    2 diseases from the University of Copenhagen DISEASES database for DSG3:
    Dermatitis     Hypersensitivity reaction type II disease

    10/25 Novoseek disease relationships for DSG3 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pemphigus vulgaris 98.5 312 8043076 (6), 7930691 (6), 9406813 (6), 11069620 (5) (see all 99)
    pemphigus 97.2 100 17263817 (5), 10021453 (3), 7543549 (2), 14639380 (2) (see all 67)
    pemphigus foliaceus 96.6 61 11982757 (5), 8688919 (2), 9424092 (2), 7543549 (1) (see all 43)
    acantholysis 95.1 40 19200441 (3), 20093368 (2), 15840580 (2), 19164289 (2) (see all 22)
    skin diseases bullous 85.2 8 20015693 (1), 15128839 (1), 12496453 (1), 17056584 (1) (see all 5)
    pemphigoid bullous 83.6 8 18833046 (2), 17263817 (1), 15242953 (1), 17026501 (1) (see all 6)
    autoimmune diseases 69.6 20 10219770 (1), 16014554 (1), 16831306 (1), 17493073 (1) (see all 16)
    skin diseases 67.6 17 9176383 (2), 10844502 (1), 1601426 (1), 19601982 (1) (see all 13)
    pemphigus erythematosus 60.3 1 1991976 (1)
    autoimmunity 54.7 6 16831306 (1), 17386081 (1), 11903226 (1), 15925832 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: DSG3 (2 documents)

    Export disorders for DSG3 gene to outside databases

    Publications
    for DSG3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DSG3 gene, integrated from 9 sources (see all 319):
    (articles sorted by number of sources associating them with DSG3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18. (PubMed id 1601426)1, 3, 9 Arnemann J....Buxton R.S. (1992)
    2. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. (PubMed id 1720352)1, 2, 9 Amagai M.... Stanley J.R. (1991)
    3. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    4. Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity. (PubMed id 17428808)1, 9 Yamamoto Y....Kitajima Y. (2007)
    5. Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens. (PubMed id 9405290)1, 9 Adams M.J.... Ali R.R. (1998)
    6. The role of desmoglein-3 in the diagnosis of squamous cell carcinoma of the lung. (PubMed id 19342368)1, 9 Savci-Heijink C.D....Vasmatzis G. (2009)
    7. DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. (PubMed id 16878157)1, 9 Chen Y.J....Cheng A.J. (2007)
    8. Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation. (PubMed id 12485422)1, 9 Hanakawa Y....Hashimoto K. (2002)
    9. Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus. (PubMed id 19164289)1, 9 Heupel W.M....Waschke J. (2009)
    10. Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism. (PubMed id 18434319)1, 9 Delva E....Kowalczyk A.P. (2008)

    External Searches for DSG3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing DSG3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1830 HGNC: 3050 AceView: DSG3 Ensembl:ENSG00000134757 euGenes: HUgn1830
    ECgene: DSG3 H-InvDB: DSG3

    Other Databases showing DSG3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DSG3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DSG3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DSG3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DSG3 gene:
    Search GeneIP for patents involving DSG3

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