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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DSG3 Gene

protein-coding   GIFtS: 60
GCID: GC18P029050

Desmoglein 3

(Previous name: desmoglein 3 (pemphigus vulgaris antigen))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Desmoglein 31 2     PVA2 3
Pemphigus Vulgaris Antigen1 2     Desmoglein 3 (Pemphigus Vulgaris Antigen)1
Cadherin Family Member 62 3     130-KD Pemphigus Vulgaris Antigen2
130 KDa Pemphigus Vulgaris Antigen2 3     desmoglein-32
CDHF62 3     

External Ids:    HGNC: 30501   Entrez Gene: 18302   Ensembl: ENSG000001347577   OMIM: 1696155   UniProtKB: P329263   

Export aliases for DSG3 gene to outside databases

Previous GC identifers: GC18P028846 GC18P027279 GC18P027281 GC18P025884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DSG3 Gene:
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a
calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently,
three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion
molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This
protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DSG3 Gene: 
DSG3 (desmoglein 3) is a protein-coding gene. Diseases associated with DSG3 include bullous impetigo, and pemphigus erythematosus, and among its related super-pathways are Apoptotic execution phase and Regulation of Apoptosis. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DSC1.

UniProtKB/Swiss-Prot: DSG3_HUMAN, P32926
Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and
intermediate filaments mediating cell-cell adhesion

Gene Wiki entry for DSG3 (Desmoglein 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.2  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DSG3 gene promoter:
         STAT5B   HFH-3   STAT1   Sox5   NCX/Ncx   Lmo2   CUTL1   STAT1alpha   AREB6   FOXI1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDSG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DSG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.1   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.1

DSG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSG3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P029050:  view genomic region     (about GC identifiers)

Start:
29,027,732 bp from pter      End:
29,058,665 bp from pter
Size:
30,934 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DSG3_HUMAN, P32926 (See protein sequence)
Recommended Name: Desmoglein-3 precursor  
Size: 999 amino acids; 107533 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, desmosome
(By similarity)
Miscellaneous: Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as
the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3
Secondary accessions: A8K2V2

Explore the universe of human proteins at neXtProt for DSG3: NX_P32926

Explore proteomics data for DSG3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32926

  • DSG3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DSG3 Protein Expression
    REFSEQ proteins: NP_001935.2  
    ENSEMBL proteins: 
     ENSP00000257189  
    Reactome Protein details: P32926
    Human Recombinant Protein Products for DSG3: 
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    Browse OriGene Protein Over-expression Lysates
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    Cloud-Clone Corp. Proteins for DSG3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0030057desmosome IEA--

    DSG3 for ontologies           About GeneDecksing



    DSG3 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for DSG3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MCDH: Cadherins / Major cadherins

    5/7 InterPro protein domains (see all 7):
     IPR027397 Catenin_binding_dom
     IPR009123 Desmoglein
     IPR000233 Cadherin_cytoplasmic-dom
     IPR002126 Cadherin
     IPR015919 Cadherin-like

    Graphical View of Domain Structure for InterPro Entry P32926

    ProtoNet protein and cluster: P32926

    3 Blocks protein domains:
    IPB002126 Cadherin
    IPB009122 Desmosomal cadherin signature
    IPB009123 Desmoglein signature


    UniProtKB/Swiss-Prot: DSG3_HUMAN, P32926
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 4 cadherin domains


    DSG3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DSG3_HUMAN, P32926
    Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and
    intermediate filaments mediating cell-cell adhesion

         Genatlas biochemistry entry for DSG3:
    desmoglein 3 (desmosomal glycoprotein,cadherin superfamily of calcium dependent cell-adhesion molecule),pemphigus
    vulgaris and herpetiform pemphigus,autoantigen (130kDa),mostly expressed in stratified squamous epithelia,lower
    spinous layer,critical for development of the epidermis and physiologic terminal differentiation of keratinocytes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    DSG3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DSG3:
     Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dsg3):
     adipose tissue  cellular  craniofacial  digestive/alimentary  growth/size 
     hematopoietic system  immune system  integument  mortality/aging  vision/eye 

    DSG3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dsg3tm1Stan for DSG3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DSG3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DSG3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DSG3 
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    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate DSG3 (see all 25):
    hsa-let-7d hsa-miR-188-5p hsa-miR-29c hsa-miR-29a hsa-let-7c hsa-miR-374a hsa-let-7g hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidDSG3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSG3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DSG3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.73
    Apoptotic execution phase0.73
    2CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.39
    3Apoptotic cleavage of cell adhesion proteins
    Apoptotic cleavage of cell adhesion proteins

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for DSG3
        Apoptotic cleavage of cell adhesion proteins
    Apoptotic execution phase
    Apoptotic cleavage of cellular proteins
    Apoptosis



    DSG3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DSG3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DSG3 (P329263 ENSP000002571894) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PKP3Q9Y4463, ENSP000003316784I2D: score=3 STRING: ENSP00000331678
    JUPP149233, ENSP000003111134I2D: score=2 STRING: ENSP00000311113
    CASP3P425743, ENSP000003110324I2D: score=1 STRING: ENSP00000311032
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007156homophilic cell adhesion IEA--

    DSG3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DSG3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DSG3

    1 HMDB Compound for DSG3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 Novoseek inferred chemical compound relationships for DSG3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ivig 57.7 7 16297153 (3), 18423257 (1), 19222460 (1), 18693160 (1)
    toxin a 39.4 2 11062541 (1), 15854034 (1)
    prednisolone 18.7 2 15942219 (1), 18410336 (1)
    serine 6.91 4 17101502 (1), 19348003 (1), 10427986 (1)
    calcium 0 23 18578707 (7), 19348003 (4), 2306347 (2), 7543549 (1) (see all 7)
    tyrosine 0 1 18434319 (1)
    acetylcholine 0 1 17377799 (1)

    Search CenterWatch for drugs/clinical trials and news about DSG3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DSG3 gene: 
    NM_001944.2  

    Unigene Cluster for DSG3:

    Desmoglein 3
    Hs.1925  [show with all ESTs]
    Unigene Representative Sequence: NM_001944
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000257189(uc002kws.3 uc002kwt.3)
    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate DSG3 (see all 25):
    hsa-let-7d hsa-miR-188-5p hsa-miR-29c hsa-miR-29a hsa-let-7c hsa-miR-374a hsa-let-7g hsa-miR-374c
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    Additional mRNA sequence: 

    AK290367.1 BC063544.1 BC105997.1 M76482.1 

    3 DOTS entries:

    DT.103524  DT.40113974  DT.91750134 

    24/72 AceView cDNA sequences (see all 72):

    BX507120 AL603251 BX099718 BC063544 M76482 NM_001944 BG679530 BP368530 
    CA432873 BG676082 BG696657 BG680338 BG677389 AA045253 AI284074 BX538327 
    CB134600 BG680199 BX642231 BE563277 AW381250 AI813438 U51696 AW873136 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DSG3 expression in normal human tissues (normalized intensities)      DSG3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DSG3 Expression
    About this image


    DSG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Epithelium
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 6 entries
             Human Oral Keritinocytes (HOK)   
             mouth   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Basal Cells Respiratory Bronchioles
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Epidermis (Integumentary System)    fully expand to see all 4 entries
             Spinous Keratinocytes Stratified Epidermis
             Human EpiDermal Keratinocytes (HEK)   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   

    See DSG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DSG3

    SOURCE GeneReport for Unigene cluster: Hs.1925

    UniProtKB/Swiss-Prot: DSG3_HUMAN, P32926
    Tissue specificity: Epidermis, tongue, tonsil, esophagus and carcinomas

        SABiosciences Expression via Pathway-Focused PCR Arrays including DSG3: 
              Lung Cancer in human mouse rat
              Adherens Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DSG3 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dsg31 , 5 desmoglein 31, 5 78.21(n)1
    75.23(a)1
      18 (11.39 cM)5
    135121  NM_030596.31  NP_085099.21 
     205103045 
    zebrafish
    (Danio rerio)
    Actinopterygii FP236168.16
    si:ch73-74h11.16
    (see all 3)
    si:ch73-74h11.1
    (see all 3)
    29(a)
    23(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(2392229-2424395)
    20(16989151-17012815)


    ENSEMBL Gene Tree for DSG3 (if available)
    TreeFam Gene Tree for DSG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DSG3 gene
    DSC12  CDH42  DSG42  CDH162  DSG12  CDH132  CDH32  DSG22  
    CDH12  CDH262  DSC32  CDH22  DSC22  CDH152  CDH172  
    6 SIMAP similar genes for DSG3 using alignment to 1 protein entry:     DSG3_HUMAN:
    DKFZp686P23184    DSG4    DSG1    DSG2    ME5    CDH1

    DSG3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/911 SNPs in DSG3 are shown (see all 911)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445157071,2
    C--29025736(+) TAGTGA/GGAACT 1 -- us2k10--------
    rs1841668101,2
    --29025757(+) CACCAA/GATTTG 1 -- us2k10--------
    rs1899328191,2
    --29025786(+) TCCTAA/GTGGAA 1 -- us2k10--------
    rs100483051,2
    C,F,H--29025949(+) CATACA/GGTCTC 1 -- us2k113Minor allele frequency- G:0.38NS EA NA WA CSA 784
    rs1914929271,2
    --29025956(+) TCTCTA/GTCCAT 1 -- us2k10--------
    rs1843726141,2
    --29026092(+) AAGAGC/TGGTAA 1 -- us2k10--------
    rs1391950831,2
    --29026094(+) GAGTGG/TTAATG 1 -- us2k10--------
    rs578461041,2
    C,F--29026220(+) AAAACA/CAAATT 1 -- us2k13Minor allele frequency- C:0.16WA CSA 122
    rs80971881,2
    C,F--29026313(+) gctcaA/Cgcctg 1 -- us2k10--------
    rs286987821,2
    C,F--29026346(+) GAGGCA/GGGAGG 1 -- us2k15Minor allele frequency- G:0.26NA WA CSA 127

    HapMap Linkage Disequilibrium report for DSG3 (29027732 - 29058665 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DSG3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2656541CNV Deletion23128226
    nsv909518CNV Loss21882294
    nsv438278CNV Loss16468122
    nsv437177CNV Loss16327808
    esv2751776CNV Gain17911159
    nsv458045CNV Gain19166990
    nsv833615CNV Gain17160897
    nsv524890CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 169615    OMIM disorders: --

    20/47 diseases for DSG3 (see all 47):    About MalaCards
    bullous impetigo    pemphigus erythematosus    herpetiform pemphigus    pemphigus vegetans
    subcorneal pustular dermatosis    multiple self healing squamous epithelioma    ritter's disease    keratoacanthoma
    inverted papilloma    castleman's disease    impetigo    follicular dendritic cell sarcoma
    pemphigus    pemphigus foliaceus    skin disease    dendritic cell sarcoma
    hailey-hailey disease    pemphigus vulgaris    bullous pemphigoid    epidermolysis bullosa acquisita

    2 diseases from the University of Copenhagen DISEASES database for DSG3:
    Dermatitis     Hypersensitivity reaction type II disease

    DSG3 for disorders           About GeneDecksing

    10/25 Novoseek inferred disease relationships for DSG3 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pemphigus vulgaris 98.5 312 8043076 (6), 7930691 (6), 9406813 (6), 11069620 (5) (see all 99)
    pemphigus 97.2 100 17263817 (5), 10021453 (3), 7543549 (2), 14639380 (2) (see all 67)
    pemphigus foliaceus 96.6 61 11982757 (5), 8688919 (2), 9424092 (2), 7543549 (1) (see all 43)
    acantholysis 95.1 40 19200441 (3), 20093368 (2), 15840580 (2), 19164289 (2) (see all 22)
    skin diseases bullous 85.2 8 20015693 (1), 15128839 (1), 12496453 (1), 17056584 (1) (see all 5)
    pemphigoid bullous 83.6 8 18833046 (2), 17263817 (1), 15242953 (1), 17026501 (1) (see all 6)
    autoimmune diseases 69.6 20 10219770 (1), 16014554 (1), 16831306 (1), 17493073 (1) (see all 16)
    skin diseases 67.6 17 9176383 (2), 10844502 (1), 1601426 (1), 19601982 (1) (see all 13)
    pemphigus erythematosus 60.3 1 1991976 (1)
    autoimmunity 54.7 6 16831306 (1), 17386081 (1), 11903226 (1), 15925832 (1) (see all 6)

    Genetic Association Database (GAD): DSG3
    Human Genome Epidemiology (HuGE) Navigator: DSG3 (2 documents)

    Export disorders for DSG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DSG3 gene, integrated from 9 sources (see all 321):
    (articles sorted by number of sources associating them with DSG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18. (PubMed id 1601426)1, 3, 9 Arnemann J....Buxton R.S. (1992)
    2. Evidence of an association between desmoglein 3 haplotypes and pemphigus vulgaris. (PubMed id 16403096)1, 4, 9 Capon F....Harman K.E. (2006)
    3. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. (PubMed id 1720352)1, 2, 9 Amagai M.... Stanley J.R. (1991)
    4. Genomewide association study for onset age in Parkins on disease. (PubMed id 19772629)1, 4 Latourelle J.C....Foroud T. (2009)
    5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    6. Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity. (PubMed id 17428808)1, 9 Yamamoto Y....Kitajima Y. (2007)
    7. Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens. (PubMed id 9405290)1, 9 Adams M.J.... Ali R.R. (1998)
    8. The role of desmoglein-3 in the diagnosis of squamous cell carcinoma of the lung. (PubMed id 19342368)1, 9 Savci-Heijink C.D....Vasmatzis G. (2009)
    9. DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. (PubMed id 16878157)1, 9 Chen Y.J....Cheng A.J. (2007)
    10. Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation. (PubMed id 12485422)1, 9 Hanakawa Y....Hashimoto K. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1830 HGNC: 3050 AceView: DSG3 Ensembl:ENSG00000134757 euGenes: HUgn1830
    ECgene: DSG3 H-InvDB: DSG3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DSG3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DSG3 gene:
    Search GeneIP for patents involving DSG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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