Aliases for DSG2 Gene
External Ids for DSG2 Gene
Previous GeneCards Identifiers for DSG2 Gene
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jul 2008]
GeneCards Summary for DSG2 Gene
DSG2 (Desmoglein 2) is a Protein Coding gene. Diseases associated with DSG2 include arrhythmogenic right ventricular dysplasia 10 and cardiomyopathy, dilated, 1bb. Among its related pathways are Cytoskeletal Signaling and Apoptotic cleavage of cellular proteins. GO annotations related to this gene include calcium ion binding and cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication. An important paralog of this gene is CDH13.
UniProtKB/Swiss-Prot for DSG2 Gene
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion