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Aliases for DSEL Gene

Aliases for DSEL Gene

  • Dermatan Sulfate Epimerase-Like 2 3 5
  • C18orf4 3 4
  • NCAG1 3 4
  • Chromosome 18 Open Reading Frame 4 2
  • EC 5.1.-.- 4

External Ids for DSEL Gene

Previous HGNC Symbols for DSEL Gene

  • C18orf4

Previous GeneCards Identifiers for DSEL Gene

  • GC18M063325
  • GC18M065173
  • GC18M061894

Summaries for DSEL Gene

GeneCards Summary for DSEL Gene

DSEL (Dermatan Sulfate Epimerase-Like) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. GO annotations related to this gene include sulfotransferase activity and isomerase activity. An important paralog of this gene is DSE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSEL Gene

Genomics for DSEL Gene

Regulatory Elements for DSEL Gene

Enhancers for DSEL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DSEL on UCSC Golden Path with GeneCards custom track

Promoters for DSEL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DSEL on UCSC Golden Path with GeneCards custom track

Genomic Location for DSEL Gene

67,506,582 bp from pter
67,516,980 bp from pter
10,399 bases
Minus strand

Genomic View for DSEL Gene

Genes around DSEL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DSEL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DSEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSEL Gene

Proteins for DSEL Gene

  • Protein details for DSEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dermatan-sulfate epimerase-like protein
    Protein Accession:
    Secondary Accessions:
    • Q17RH1
    • Q6P5Z3

    Protein attributes for DSEL Gene

    1212 amino acids
    Molecular mass:
    139238 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI17326.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN32895.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DSEL Gene

Proteomics data for DSEL Gene at MOPED

Post-translational modifications for DSEL Gene

  • Glycosylation at Asn 28, Asn 666, Asn 688, Asn 709, and Asn 874
  • Modification sites at PhosphoSitePlus

Other Protein References for DSEL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DSEL Gene

Domains & Families for DSEL Gene

Protein Domains for DSEL Gene


Suggested Antigen Peptide Sequences for DSEL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dermatan-sulfate isomerase family.
  • Belongs to the dermatan-sulfate isomerase family.
genes like me logo Genes that share domains with DSEL: view

No data available for Gene Families for DSEL Gene

Function for DSEL Gene

Enzyme Numbers (IUBMB) for DSEL Gene

genes like me logo Genes that share phenotypes with DSEL: view

Animal Models for DSEL Gene

MGI Knock Outs for DSEL:

Animal Model Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DSEL Gene

Localization for DSEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for DSEL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DSEL Gene COMPARTMENTS Subcellular localization image for DSEL gene
Compartment Confidence
golgi apparatus 5
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DSEL Gene

Pathways & Interactions for DSEL Gene

genes like me logo Genes that share pathways with DSEL: view

Interacting Proteins for DSEL Gene

Selected Interacting proteins: Q8IZU8-DSEL_HUMAN for DSEL Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for DSEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030205 dermatan sulfate metabolic process IEA --
genes like me logo Genes that share ontologies with DSEL: view

No data available for SIGNOR curated interactions for DSEL Gene

Drugs & Compounds for DSEL Gene

No Compound Related Data Available

Transcripts for DSEL Gene

mRNA/cDNA for DSEL Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DSEL Gene

Dermatan sulfate epimerase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DSEL Gene

No ASD Table

Relevant External Links for DSEL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DSEL Gene

mRNA expression in normal human tissues for DSEL Gene

Protein differential expression in normal tissues from HIPED for DSEL Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DSEL Gene

SOURCE GeneReport for Unigene cluster for DSEL Gene Hs.124673

mRNA Expression by UniProt/SwissProt for DSEL Gene

Tissue specificity: Expressed in different brain areas as well as in multiple other peripheral tissues.
genes like me logo Genes that share expression patterns with DSEL: view

Protein tissue co-expression partners for DSEL Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DSEL Gene

Orthologs for DSEL Gene

This gene was present in the common ancestor of chordates.

Orthologs for DSEL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DSEL 35
  • 86.36 (n)
  • 90.1 (a)
  • 90 (a)
(Canis familiaris)
Mammalia DSEL 35
  • 92.38 (n)
  • 94.72 (a)
  • 94 (a)
(Mus musculus)
Mammalia Dsel 35
  • 88.73 (n)
  • 89.73 (a)
Dsel 16
Dsel 36
  • 90 (a)
(Pan troglodytes)
Mammalia DSEL 35
  • 99.86 (n)
  • 99.84 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dsel 35
  • 88.01 (n)
  • 88.73 (a)
(Monodelphis domestica)
Mammalia DSEL 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia DSEL 36
  • 77 (a)
(Gallus gallus)
Aves DSEL 35
  • 76.49 (n)
  • 78.05 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia DSEL 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dsel 35
  • 70.65 (n)
  • 70.87 (a)
(Danio rerio)
Actinopterygii dsela 35
  • 62.78 (n)
  • 61.32 (a)
DSEL (2 of 2) 36
  • 62 (a)
dsela 36
  • 58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for DSEL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DSEL Gene

Gene Tree for DSEL (if available)
Gene Tree for DSEL (if available)

Paralogs for DSEL Gene

Paralogs for DSEL Gene

(1) SIMAP similar genes for DSEL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DSEL: view

Variants for DSEL Gene

Sequence variations from dbSNP and Humsavar for DSEL Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_030833 -
VAR_030834 -
VAR_036528 A colorectal cancer sample
VAR_057759 -

Structural Variations from Database of Genomic Variants (DGV) for DSEL Gene

Variant ID Type Subtype PubMed ID
nsv458102 CNV Loss 19166990
nsv909748 CNV Gain 21882294

Variation tolerance for DSEL Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.69; 91.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DSEL Gene

Disorders for DSEL Gene

Relevant External Links for DSEL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DSEL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DSEL Gene

Publications for DSEL Gene

  1. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3 48 67
  2. Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5- epimerase is identical to SART2. (PMID: 16505484) Maccarana M. … Malmstroem A. (J. Biol. Chem. 2006) 2 3
  3. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung Y.J. … Rao D.C. (Am. J. Hypertens. 2015) 3
  4. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PMID: 22779921) Long P. … Rose S. (Eur. J. Neurosci. 2012) 3
  5. A maternally inherited chromosome 18q22.1 deletion in a male with late-presenting diaphragmatic hernia and microphthalmia-evaluation of DSEL as a candidate gene for the diaphragmatic defect. (PMID: 20358601) Zayed H. … Slavotinek A.M. (Am. J. Med. Genet. A 2010) 3

Products for DSEL Gene

Sources for DSEL Gene