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Aliases for DSEL Gene

Aliases for DSEL Gene

  • Dermatan Sulfate Epimerase-Like 2 3
  • C18orf4 3 4
  • NCAG1 3 4
  • Chromosome 18 Open Reading Frame 4 2
  • EC 5.1.-.- 4

External Ids for DSEL Gene

Previous HGNC Symbols for DSEL Gene

  • C18orf4

Previous GeneCards Identifiers for DSEL Gene

  • GC18M063325
  • GC18M065173
  • GC18M061894

Summaries for DSEL Gene

GeneCards Summary for DSEL Gene

DSEL (Dermatan Sulfate Epimerase-Like) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and isomerase activity. An important paralog of this gene is DSE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSEL Gene

Genomics for DSEL Gene

Regulatory Elements for DSEL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DSEL Gene

Chromosome:
18
Start:
67,506,582 bp from pter
End:
67,516,980 bp from pter
Size:
10,399 bases
Orientation:
Minus strand

Genomic View for DSEL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DSEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSEL Gene

Proteins for DSEL Gene

  • Protein details for DSEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZU8-DSEL_HUMAN
    Recommended name:
    Dermatan-sulfate epimerase-like protein
    Protein Accession:
    Q8IZU8
    Secondary Accessions:
    • Q17RH1
    • Q6P5Z3

    Protein attributes for DSEL Gene

    Size:
    1212 amino acids
    Molecular mass:
    139238 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17326.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN32895.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DSEL Gene

Proteomics data for DSEL Gene at MOPED

Post-translational modifications for DSEL Gene

  • Glycosylation at Asn 28, Asn 666, Asn 688, Asn 709, and Asn 874
  • Modification sites at PhosphoSitePlus

Other Protein References for DSEL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DSEL Gene

Domains & Families for DSEL Gene

Protein Domains for DSEL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DSEL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZU8

UniProtKB/Swiss-Prot:

DSEL_HUMAN :
  • Belongs to the dermatan-sulfate isomerase family.
Family:
  • Belongs to the dermatan-sulfate isomerase family.
genes like me logo Genes that share domains with DSEL: view

No data available for Gene Families for DSEL Gene

Function for DSEL Gene

Enzyme Numbers (IUBMB) for DSEL Gene

Gene Ontology (GO) - Molecular Function for DSEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity --
GO:0047757 chondroitin-glucuronate 5-epimerase activity IEA --
genes like me logo Genes that share ontologies with DSEL: view

Phenotypes for DSEL Gene

genes like me logo Genes that share phenotypes with DSEL: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DSEL

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , Transcription Factor Targets and HOMER Transcription for DSEL Gene

Localization for DSEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for DSEL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DSEL Gene COMPARTMENTS Subcellular localization image for DSEL gene
Compartment Confidence
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for DSEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DSEL: view

Pathways & Interactions for DSEL Gene

genes like me logo Genes that share pathways with DSEL: view

Interacting Proteins for DSEL Gene

Selected Interacting proteins: Q8IZU8-DSEL_HUMAN for DSEL Gene via I2D

Symbol External ID(s) Details
PRKAG2

Gene Ontology (GO) - Biological Process for DSEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030205 dermatan sulfate metabolic process --
GO:0030208 dermatan sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with DSEL: view

No data available for SIGNOR curated interactions for DSEL Gene

Drugs & Compounds for DSEL Gene

No Compound Related Data Available

Transcripts for DSEL Gene

mRNA/cDNA for DSEL Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DSEL Gene

Dermatan sulfate epimerase-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DSEL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DSEL Gene

No ASD Table

Relevant External Links for DSEL Gene

GeneLoc Exon Structure for
DSEL
ECgene alternative splicing isoforms for
DSEL

Expression for DSEL Gene

mRNA expression in normal human tissues for DSEL Gene

Protein differential expression in normal tissues from HIPED for DSEL Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DSEL Gene



SOURCE GeneReport for Unigene cluster for DSEL Gene Hs.124673

mRNA Expression by UniProt/SwissProt for DSEL Gene

Q8IZU8-DSEL_HUMAN
Tissue specificity: Expressed in different brain areas as well as in multiple other peripheral tissues.
genes like me logo Genes that share expression patterns with DSEL: view

Protein tissue co-expression partners for DSEL Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DSEL Gene

Orthologs for DSEL Gene

This gene was present in the common ancestor of chordates.

Orthologs for DSEL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DSEL 35
  • 86.36 (n)
  • 90.1 (a)
DSEL 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DSEL 35
  • 92.38 (n)
  • 94.72 (a)
DSEL 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dsel 35
  • 88.73 (n)
  • 89.73 (a)
Dsel 16
Dsel 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DSEL 35
  • 99.86 (n)
  • 99.84 (a)
DSEL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dsel 35
  • 88.01 (n)
  • 88.73 (a)
oppossum
(Monodelphis domestica)
Mammalia DSEL 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DSEL 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DSEL 35
  • 76.49 (n)
  • 78.05 (a)
DSEL 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DSEL 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dsel 35
  • 70.65 (n)
  • 70.87 (a)
zebrafish
(Danio rerio)
Actinopterygii dsela 35
  • 62.78 (n)
  • 61.32 (a)
DSEL (2 of 2) 36
  • 62 (a)
OneToMany
dsela 36
  • 58 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for DSEL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DSEL Gene

ENSEMBL:
Gene Tree for DSEL (if available)
TreeFam:
Gene Tree for DSEL (if available)

Paralogs for DSEL Gene

Paralogs for DSEL Gene

(1) SIMAP similar genes for DSEL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DSEL: view

Variants for DSEL Gene

Sequence variations from dbSNP and Humsavar for DSEL Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs267605241 untested 67,512,894(+) GCAAA(A/G)CACGA reference, missense
rs267605242 untested 67,513,245(+) TCCAG(A/G)AATAT reference, missense
rs267605243 untested 67,514,422(+) ACTTG(A/G)ATGAA reference, missense
VAR_030833 -
VAR_030834 -

Structural Variations from Database of Genomic Variants (DGV) for DSEL Gene

Variant ID Type Subtype PubMed ID
nsv458102 CNV Loss 19166990
nsv909748 CNV Gain 21882294

Variation tolerance for DSEL Gene

Residual Variation Intolerance Score: 44.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.69; 91.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DSEL Gene

HapMap Linkage Disequilibrium report
DSEL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSEL Gene

Disorders for DSEL Gene

Relevant External Links for DSEL

Genetic Association Database (GAD)
DSEL
Human Genome Epidemiology (HuGE) Navigator
DSEL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DSEL
genes like me logo Genes that share disorders with DSEL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DSEL Gene

Publications for DSEL Gene

  1. Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5- epimerase is identical to SART2. (PMID: 16505484) Maccarana M. … Malmstroem A. (J. Biol. Chem. 2006) 2 67
  2. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung Y.J. … Rao D.C. (Am. J. Hypertens. 2015) 67
  3. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PMID: 22779921) Long P. … Rose S. (Eur. J. Neurosci. 2012) 67
  4. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 67
  5. A maternally inherited chromosome 18q22.1 deletion in a male with late-presenting diaphragmatic hernia and microphthalmia-evaluation of DSEL as a candidate gene for the diaphragmatic defect. (PMID: 20358601) Zayed H. … Slavotinek A.M. (Am. J. Med. Genet. A 2010) 67

Products for DSEL Gene

Sources for DSEL Gene

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