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Aliases for DSEL Gene

Aliases for DSEL Gene

  • Dermatan Sulfate Epimerase-Like 2 3
  • C18orf4 3 4 6
  • NCAG1 3 4 6
  • Dermatan-Sulfate Epimerase-Like Protein 3
  • Chromosome 18 Open Reading Frame 4 2
  • EC 5.1.-.- 4

External Ids for DSEL Gene

Previous HGNC Symbols for DSEL Gene

  • C18orf4

Previous GeneCards Identifiers for DSEL Gene

  • GC18M063325
  • GC18M065173
  • GC18M061894

Summaries for DSEL Gene

GeneCards Summary for DSEL Gene

DSEL (Dermatan Sulfate Epimerase-Like) is a Protein Coding gene. Diseases associated with DSEL include colorectal cancer. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include sulfotransferase activity and isomerase activity. An important paralog of this gene is DSE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSEL Gene

Genomics for DSEL Gene

Regulatory Elements for DSEL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DSEL Gene

67,506,582 bp from pter
67,516,980 bp from pter
10,399 bases
Minus strand

Genomic View for DSEL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DSEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSEL Gene

Proteins for DSEL Gene

  • Protein details for DSEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dermatan-sulfate epimerase-like protein
    Protein Accession:
    Secondary Accessions:
    • Q17RH1
    • Q6P5Z3

    Protein attributes for DSEL Gene

    1212 amino acids
    Molecular mass:
    139238 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI17326.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN32895.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DSEL Gene

Proteomics data for DSEL Gene at MOPED

Post-translational modifications for DSEL Gene

  • Glycosylation at Asn28, Asn666, Asn688, Asn709, and Asn874
  • Modification sites at PhosphoSitePlus

Other Protein References for DSEL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DSEL Gene

Domains for DSEL Gene

Protein Domains for DSEL Gene

Suggested Antigen Peptide Sequences for DSEL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IZU8
  • Belongs to the dermatan-sulfate isomerase family.
genes like me logo Genes that share domains with DSEL: view

No data available for Gene Families for DSEL Gene

Function for DSEL Gene

Enzyme Numbers (IUBMB) for DSEL Gene

Gene Ontology (GO) - Molecular Function for DSEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with DSEL: view

Phenotypes for DSEL Gene

GenomeRNAi human phenotypes for DSEL:
genes like me logo Genes that share phenotypes with DSEL: view

Animal Model Products

miRNA for DSEL Gene

miRTarBase miRNAs that target DSEL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DSEL

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for DSEL Gene

Localization for DSEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for DSEL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DSEL Gene COMPARTMENTS Subcellular localization image for DSEL gene
Compartment Confidence
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DSEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DSEL: view

Pathways for DSEL Gene

genes like me logo Genes that share pathways with DSEL: view

Interacting Proteins for DSEL Gene

Selected Interacting proteins: Q8IZU8-DSEL_HUMAN for DSEL Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for DSEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030208 dermatan sulfate biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with DSEL: view

Transcripts for DSEL Gene

mRNA/cDNA for DSEL Gene

(44) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DSEL Gene

Dermatan sulfate epimerase-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DSEL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DSEL Gene

No ASD Table

Relevant External Links for DSEL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DSEL Gene

mRNA expression in normal human tissues for DSEL Gene

Protein differential expression in normal tissues for DSEL Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DSEL Gene

SOURCE GeneReport for Unigene cluster for DSEL Gene Hs.124673

mRNA Expression by UniProt/SwissProt for DSEL Gene

Tissue specificity: Expressed in different brain areas as well as in multiple other peripheral tissues.
genes like me logo Genes that share expressions with DSEL: view

Expression partners for DSEL Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DSEL Gene

Orthologs for DSEL Gene

This gene was present in the common ancestor of chordates.

Orthologs for DSEL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DSEL 35
  • 86.36 (n)
  • 90.1 (a)
  • 90 (a)
(Canis familiaris)
Mammalia DSEL 35
  • 92.38 (n)
  • 94.72 (a)
  • 94 (a)
(Mus musculus)
Mammalia Dsel 35
  • 88.73 (n)
  • 89.73 (a)
Dsel 16
Dsel 36
  • 90 (a)
(Pan troglodytes)
Mammalia DSEL 35
  • 99.86 (n)
  • 99.84 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dsel 35
  • 88.01 (n)
  • 88.73 (a)
(Monodelphis domestica)
Mammalia DSEL 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia DSEL 36
  • 77 (a)
(Gallus gallus)
Aves DSEL 35
  • 76.49 (n)
  • 78.05 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia DSEL 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dsel 35
  • 70.65 (n)
  • 70.87 (a)
(Danio rerio)
Actinopterygii dsela 35
  • 62.78 (n)
  • 61.32 (a)
DSEL (2 of 2) 36
  • 62 (a)
dsela 36
  • 58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for DSEL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DSEL Gene

Gene Tree for DSEL (if available)
Gene Tree for DSEL (if available)

Paralogs for DSEL Gene

Paralogs for DSEL Gene

Selected SIMAP similar genes for DSEL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DSEL: view

Variants for DSEL Gene

Sequence variations from dbSNP and Humsavar for DSEL Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs2279269 - 67,512,592(+) TGTGG(A/G)TTCCA reference, missense
rs3073946 -- 67,510,866(-) GTGTG(-/TG/TGTG)CACGC utr-variant-3-prime
rs7227452 -- 67,507,549(+) TGTAT(A/C)CCAAG utr-variant-3-prime
rs7227616 -- 67,507,587(+) GAAAT(C/T)GTTGC utr-variant-3-prime
rs9951268 -- 67,508,969(+) gacct(C/T)gtgat utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DSEL Gene

Variant ID Type Subtype PubMed ID
nsv458102 CNV Loss 19166990
nsv909748 CNV Gain 21882294

Relevant External Links for DSEL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSEL Gene

Disorders for DSEL Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DSEL Gene in MalaCards »

(1) Diseases for DSEL Gene including...

Relevant External Links for DSEL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DSEL: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DSEL Gene

Publications for DSEL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5- epimerase is identical to SART2. (PMID: 16505484) Maccarana M. … Malmstroem A. (J. Biol. Chem. 2006) 2 3
  3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 48
  4. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3 48
  5. A novel CpG-associated brain-expressed candidate gene for chromosome 18q-linked bipolar disorder. (PMID: 12556911) Goossens D. … Del-Favero J. (Mol. Psychiatry 2003) 3 4

Products for DSEL Gene

Sources for DSEL Gene

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