Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DSE Gene

protein-coding   GIFtS: 55
GCID: GC06P116584

Dermatan Sulfate Epimerase

(Previous name: squamous cell carcinoma antigen recognized by T cells 2)
(Previous symbol: SART2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dermatan Sulfate Epimerase1 2     Squamous Cell Carcinoma Antigen Recognized By T Cells 21
SART21 2 3 5     DSEP2
Chondroitin-Glucuronate 5-Epimerase2 3     DSEPI2
Squamous Cell Carcinoma Antigen Recognized By T-Cells 22 3     Dermatan-Sulfate Epimerase2
SART-22 3     EC 5.1.3.193
DS Epimerase2 3     

External Ids:    HGNC: 211441   Entrez Gene: 299402   Ensembl: ENSG000001118177   OMIM: 6059425   UniProtKB: Q9UL013   

Export aliases for DSE gene to outside databases

Previous GC identifers: GC06P116708 GC06P116603 GC06P114181 GC06P116578 GC06P116581 GC06P116582 GC06P116583


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DSE Gene:
The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of
inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for
specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DSE Gene: 
DSE (dermatan sulfate epimerase) is a protein-coding gene. Diseases associated with DSE include cycloplegia, and anisometropia, and among its related super-pathways are chondroitin sulfate biosynthesis and Metabolic pathways. GO annotations related to this gene include chondroitin-glucuronate 5-epimerase activity. An important paralog of this gene is DSEL.

UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01
Function: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues

Gene Wiki entry for DSE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DSE gene promoter:
         USF1   AML1a   STAT5A   Max   SRY   POU2F1   USF-1   POU2F1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDSE promoter sequence
   Search SABiosciences Chromatin IP Primers for DSE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22

DSE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSE gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P116584:  view genomic region     (about GC identifiers)

Start:
116,575,336 bp from pter      End:
116,762,424 bp from pter
Size:
187,089 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01 (See protein sequence)
Recommended Name: Dermatan-sulfate epimerase precursor  
Size: 958 amino acids; 109773 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q5R3K6

Explore the universe of human proteins at neXtProt for DSE: NX_Q9UL01

Explore proteomics data for DSE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UL01

  • DSE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DSE Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001074445.1  NP_037484.1  

    ENSEMBL proteins: 
     ENSP00000397597   ENSP00000404049   ENSP00000332151   ENSP00000446378   ENSP00000441152  
     ENSP00000352567  
    Reactome Protein details: Q9UL01
    Human Recombinant Protein Products for DSE: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DSE
    GenScript Custom Purified and Recombinant Proteins Services for DSE
    Novus Biologicals DSE Proteins
    Novus Biologicals DSE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DSE 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005783endoplasmic reticulum IDA10679095
    GO:0005794Golgi apparatus IDA10679095
    GO:0016021integral to membrane IEA--

    DSE for ontologies           About GeneDecksing



    DSE Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DSE
    GenScript Custom Superior Antibodies Services for DSE
    Novus Biologicals DSE Antibodies
    Abcam antibodies for DSE
    Cloud-Clone Corp. Antibodies for DSE 
    Search ThermoFisher Antibodies for DSE
    LSBio Antibodies in human, mouse, rat for DSE 

    Assay Products for DSE: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DSE
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DSE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DSE 
    Cloud-Clone Corp. CLIAs for DSE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9UL01

    UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01
    Similarity: Belongs to the dermatan-sulfate isomerase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DSE_HUMAN, Q9UL01
    Function: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues
    Catalytic activity: Chondroitin D-glucuronate = dermatan L-iduronate

         Enzyme Number (IUBMB): EC 5.1.3.191

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0047757chondroitin-glucuronate 5-epimerase activity IDA16505484
         
    DSE for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DSE:
     Increased HDAC inhibitor resis 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dse):
     growth/size  integument  limbs/digits/tail  reproductive system 

    DSE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dsetm1Mmac for DSE

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DSE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DSE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DSE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DSE 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DSE
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DSE (see all 11):
    hsa-miR-4307 hsa-miR-3200-5p hsa-miR-448 hsa-miR-507 hsa-miR-587 hsa-miR-153 hsa-miR-9 hsa-miR-129-5p
    SwitchGear 3'UTR luciferase reporter plasmidDSE 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DSE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DSE
    Sirion Biotech Customized adenovirus for overexpression of DSE

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DSE (see all 13)
    OriGene ORF clones in mouse, rat for DSE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DSE (NM_001080976)
    Sino Biological Human cDNA Clone for DSE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSE
    Sirion Biotech Customized lentivirus for stable overexpression of DSE 
                         Customized lentivirus expression plasmids for stable overexpression of DSE 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DSE
    Search LifeMap BioReagents cell lines for DSE
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DSE About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1chondroitin sulfate biosynthesis
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.74
    dermatan sulfate biosynthesis0.64
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    4A tetrasaccharide linker sequence is required for GAG synthesis
    Chondroitin sulfate/dermatan sulfate metabolism0.54
    5CS/DS degradation
    Dermatan sulfate biosynthesis0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for DSE
        dermatan sulfate biosynthesis (late stages)
    dermatan sulfate biosynthesis


    5/18        Reactome Pathways for DSE (see all 18)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Dermatan sulfate biosynthesis


    2         Kegg Pathways  (Kegg details for DSE):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
    Metabolic pathways

    UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01
    Pathway: Glycan metabolism; chondroitin sulfate biosynthesis
    Pathway: Glycan metabolism; heparan sulfate biosynthesis


    DSE for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DSE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for DSE (ENSP000003321514) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCANENSP000003312104STRING: ENSP00000331210
    BGNENSP000003273364STRING: ENSP00000327336
    CHPFENSP000002437764STRING: ENSP00000243776
    CHST14ENSP000003072974STRING: ENSP00000307297
    CHST15ENSP000003339474STRING: ENSP00000333947
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0015012heparan sulfate proteoglycan biosynthetic process IEA--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0030206chondroitin sulfate biosynthetic process IEA--

    DSE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DSE

    5 HMDB Compounds for DSE    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    D-Glucuronic acidD-(+)-glucuronate (see all 15)6556-12-3--
    D-Glucurono-6,3-lactoneD-Glucurono-3,6-lactone (see all 18)32449-92-6--
    DermatanChondroitin sulfate B (see all 13)24967-94-0--
    Iduronic acidL-Iduronate (see all 3)3402-98-0--

    Search CenterWatch for drugs/clinical trials and news about DSE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DSE gene (2 alternative transcripts): 
    NM_001080976.1  NM_013352.2  

    Unigene Cluster for DSE:

    Dermatan sulfate epimerase
    Hs.458358  [show with all ESTs]
    Unigene Representative Sequence: NM_003309
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430252(uc003pwq.1) ENST00000607094 ENST00000452085(uc003pws.3)
    ENST00000331677(uc011ebg.2 uc003pwt.3 uc003pwu.3) ENST00000606265
    ENST00000606712 ENST00000540275(uc011ebf.1) ENST00000537543 ENST00000359564

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DSE
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DSE (see all 11):
    hsa-miR-4307 hsa-miR-3200-5p hsa-miR-448 hsa-miR-507 hsa-miR-587 hsa-miR-153 hsa-miR-9 hsa-miR-129-5p
    SwitchGear 3'UTR luciferase reporter plasmidDSE 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DSE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSE
    Clone
    Products:
         
    OriGene clones in human, mouse for DSE (see all 13)
    OriGene ORF clones in mouse, rat for DSE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DSE (NM_001080976)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSE
    Sirion Biotech Customized lentivirus for stable overexpression of DSE 
                         Customized lentivirus expression plasmids for stable overexpression of DSE 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DSE
    OriGene qSTAR qPCR primer pairs in human, mouse for DSE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DSE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSE

    Additional mRNA sequence: 

    AF042181.1 AF098066.1 AK095123.1 AK096882.1 AK293872.1 AK298559.1 AK301513.1 AK316303.1 
    AL832471.1 BC039245.1 BC043526.1 CR533535.1 

    24/36 DOTS entries (see all 36):

    DT.317026  DT.75130090  DT.95070676  DT.99947066  DT.309644  DT.99943305  DT.100798448  DT.100060249 
    DT.95115225  DT.100798450  DT.87017105  DT.97870393  DT.100060251  DT.100803898  DT.91890461  DT.95232643 
    DT.100709181  DT.100042463  DT.100742632  DT.40122462  DT.95233470  DT.100709193  DT.100703867  DT.100798452 

    24/148 AceView cDNA sequences (see all 148):

    NM_013352 BI461157 AI569987 BQ445872 BX110619 AI927761 AI087828 BX348375 
    AI452787 AF098066 AI393799 AW628136 AA333245 BF982595 AL599182 AI431774 
    BQ020889 CF242815 AA665686 BC043526 AI492462 AI307651 BU185635 BF963620 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DSE    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
    SP1:              -     -     -     -     -                       -                     
    SP2:                                                              -                     
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for DSE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DSE expression in normal human tissues (normalized intensities)      DSE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DSE Expression
    About this image


    DSE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Bone (Muscoskeletal System)
             Human fetal bone marrow-derived mesenchymal stromal cells

    See DSE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DSE

    SOURCE GeneReport for Unigene cluster: Hs.458358

    UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01
    Tissue specificity: Ubiquitously expressed with higher expression in kidney and ovary and lower expression in
    brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and
    adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some
    adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level)

        SABiosciences Custom PCR Arrays for DSE
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DSE
    OriGene qSTAR qPCR primer pairs in human, mouse for DSE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DSE
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSE
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DSE gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dse1 , 5 dermatan sulfate epimerase1, 5 87.5(n)1
    93.94(a)1
      10 (18.85 cM)5
    2128981  NM_172508.21  NP_766096.11 
     341513945 
    chicken
    (Gallus gallus)
    Aves DSE1 dermatan sulfate epimerase 78.81(n)
    85.18(a)
      421745  XM_419777.3  XP_419777.3 
    lizard
    (Anolis carolinensis)
    Reptilia DSE6
    Uncharacterized protein
    83(a)
    1 ↔ 1
    1(186233249-186281507)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.37102 Transcribed sequence with moderate similarity to protein more 77.81(n)    142005898 
    zebrafish
    (Danio rerio)
    Actinopterygii dse1 dermatan sulfate epimerase 65.36(n)
    66.17(a)
      568713  NM_001030225.1  NP_001025396.1 


    ENSEMBL Gene Tree for DSE (if available)
    TreeFam Gene Tree for DSE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DSE gene
    DSEL2  
    1 SIMAP similar gene for DSE using alignment to 3 protein entries:     DSE_HUMAN (see all proteins):
    DSEL

    DSE for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for DSE (see all 9)
    PGOHUM00000259512 PGOHUM00000259674 PGOHUM00000259675 PGOHUM00000260410 PGOHUM00000260494


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2817 SNPs in DSE are shown (see all 2817)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828239771,2
    --116603402(+) AAAAGG/TAATAT 1 -- int10--------
    rs2012328571,2
    --116603521(+) TCCTA-/TTTTTT 1 -- int10--------
    rs1874265101,2
    --116603609(+) ATTAAC/TGTAAT 1 -- int10--------
    rs1429964811,2
    C--116603779(+) TTTGA-/ATATATA 1 -- int10--------
    rs343595931,2
    C--116603780(+) ATATA-/TAGAGAA 1 -- int10--------
    rs1412139071,2
    --116603994(+) TATGTC/GCTATT 1 -- int10--------
    rs1473457481,2
    --116604080(+) TCAGGC/GAGTTA 1 -- int10--------
    rs1394876201,2
    --116604144(+) ATTATA/CGTAGG 1 -- int10--------
    rs1923758991,2
    --116604223(+) TTTACA/GTGACA 1 -- int10--------
    rs1847208601,2
    --116604340(+) GCATTA/GAAGTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for DSE (116575336 - 116762424 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DSE:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1982590CNV Deletion18987734
    esv2732605CNV Deletion23290073
    esv2732607CNV Deletion23290073
    esv2504683CNV Deletion19546169
    esv2732604CNV Deletion23290073
    nsv348791CNV Loss16902084
    esv5754CNV Loss19470904
    nsv524705CNV Loss19592680
    nsv523972CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DSE
    DNA2.0 Custom Variant and Variant Library Synthesis for DSE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605942    OMIM disorders: --

    13 diseases for DSE:    About MalaCards
    cycloplegia    anisometropia    esophagus squamous cell carcinoma    squamous cell carcinoma
    amblyopia    astigmatism    hyperopia    morquio syndrome b
    myopia    renal cell carcinoma    adenocarcinoma    melanoma
    breast cancer

    6 diseases from the University of Copenhagen DISEASES database for DSE:
    Astigmatism     Myopia     Anisometropia     Hyperopia
    Amblyopia     Cycloplegia

    DSE for disorders           About GeneDecksing

    Genetic Association Database (GAD): DSE
    Human Genome Epidemiology (HuGE) Navigator: DSE (4 documents)

    Export disorders for DSE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DSE gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with DSE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5- epimerase is identical to SART2. (PubMed id 16505484)1, 2, 3 Maccarana M.... Malmstroem A. (2006)
    2. Expression of tumor rejection antigens in colorectal carcinomas. (PubMed id 11920522)1, 3, 9 Sasatomi T....Shirouzu K. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL. (PubMed id 10679095)1, 2 Nakao M....Itoh K. (2000)
    6. Expression of tumor-rejection antigens in gynecologic cancers. (PubMed id 11092984)1, 9 Tanaka S....Itoh K. (2000)
    7. Dermatan sulfate is involved in the tumorigenic proper ties of esophagus squamous cell carcinoma. (PubMed id 22350411)1 Thelin M.A....Malmstrom A. (2012)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function. (PubMed id 19004833)1 Pacheco B....MalmstrAPm L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29940 HGNC: 21144 AceView: SART2 Ensembl:ENSG00000111817 euGenes: HUgn29940
    ECgene: DSE Kegg: 29940 H-InvDB: DSE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DSE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DSE gene:
    Search GeneIP for patents involving DSE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DSE  
     OriGene qPCR primer pairs and template standards for DSE   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DSE  
     OriGene qSTAR qPCR primer pairs in human, mouse for DSE   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DSE   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DSE   OriGene Custom Protein Services for DSE  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DSE
     QIAGEN SeqTarget long-range PCR primers for resequencing DSE
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSE
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSE
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSE
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSE
     GenScript Custom Purified and Recombinant Proteins Services for DSE GenScript cDNA clones with any tag delivered in your preferred vector for DSE
     GenScript Custom Assay Services for DSE GenScript Custom Superior Antibodies Services for DSE
     GenScript Custom overexpressing Cell Line Services for DSE CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DSE promoter
     Search Chromatin IP Primers for DSE
     RT2 qPCR Primer Assay in human, mouse, rat DSE
     Search GNC Networks for DSE
     SABiosciences Custom PCR Arrays for DSE
     Search Tocris compounds for DSE
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for DSE
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DSE antibodies
     DSE proteins
     DSE lysates
     Antibodies for DSE
     See all of Abcam's Antibodies, Kits and Proteins for DSE
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DSE
     Antibodies for DSE
     ELISAs for DSE
     CLIAs for DSE
     Search LifeMap BioReagents cell lines for DSE
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSE
     SwitchGear 3'UTR luciferase reporter plasmids for DSE
     SwitchGear Promoter luciferase reporter plasmids for DSE
     Search ThermoFisher Antibodies for DSE
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSE
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DSE
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DSE
    Customized:
     lentivirus for stable overexpression of DSE
     lentivirus expression plasmids for stable overexpression of DSE
     adenovirus for overexpression of DSE
     LSBio Antibodies in human, mouse, rat for DSE
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DSE gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4