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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DSE Gene

protein-coding   GIFtS: 52
GCID: GC06P116583

dermatan sulfate epimerase

(Previous name: squamous cell carcinoma antigen recognized by T cells 2...)
(Previous symbol: SART2)
 Explore 12 diseases affiliated with
DSE via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DSE    

Aliases
for DSE gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dermatan Sulfate Epimerase1 2     SART-22 3
SART21 2 3 5     DS Epimerase2 3
DSEPI1 2     DSEP2
Squamous Cell Carcinoma Antigen Recognized By T Cells 21 2     Dermatan-Sulfate Epimerase2
Chondroitin-Glucuronate 5-Epimerase2 3     EC 5.1.3.193
Squamous Cell Carcinoma Antigen Recognized By T-Cells 22 3     

External Ids:    HGNC: 211441   Entrez Gene: 299402   Ensembl: ENSG000001118177   OMIM: 6059425   UniProtKB: Q9UL013   

Export aliases for DSE gene to outside databases

Previous GC identifers: GC06P116708 GC06P116603 GC06P114181 GC06P116578 GC06P116581 GC06P116582


Summaries
for DSE gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DSE:
The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of
inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for
specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding
the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01
Function: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues

Gene Wiki entry for DSE


Genomic Views
for DSE gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DSE gene promoter:
         USF1   AML1a   STAT5A   Max   SRY   POU2F1   USF-1   POU2F1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DSE promoter sequence
   Search SABiosciences Chromatin IP Primers for DSE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22

DSE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSE gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P116583:  view genomic region     (about GC identifiers)

Start:
 116,575,336 bp from pter      End:
 116,759,442 bp from pter
Size:
 184,107 bases      Orientation:
 plus strand

Proteins
for DSE gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01 (See protein sequence)
Recommended Name: Dermatan-sulfate epimerase precursor  
Size: 958 amino acids; 109773 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q5R3K6

Explore the universe of human proteins at neXtProt for DSE: NX_Q9UL01

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UL01

    • DSE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001074445.1  NP_037484.1  

    ENSEMBL proteins: 
     ENSP00000397597   ENSP00000332151   ENSP00000446378   ENSP00000441152   ENSP00000404049  
     ENSP00000352567  
    Reactome Protein details: Q9UL01
    Human Recombinant Protein Products: 
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    Novus Biologicals DSE Proteins
    Novus Biologicals DSE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DSE

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005783endoplasmic reticulum IDA10679095
    GO:0005794Golgi apparatus IDA10679095
    GO:0016021integral to membrane IEA--


    DSE for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DSE

    Protein Domains /
    Families
    for DSE gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9UL01

    UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01
    Similarity: Belongs to the dermatan-sulfate isomerase family


    Function
    for DSE gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01
    Function: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues
    Catalytic activity: Chondroitin D-glucuronate = dermatan L-iduronate

    Enzyme Number (IUBMB): EC 5.1.3.191

    miRNA
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    hsa-miR-4307 hsa-miR-3200-5p hsa-miR-448 hsa-miR-507 hsa-miR-587 hsa-miR-153 hsa-miR-9 hsa-miR-129-5p
    SwitchGear 3'UTR luciferase reporter plasmid: DSE 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DSE (see all 7)
    OriGene shRNA RFP: DSE
    OriGene siRNA: DSE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSE

    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0047757chondroitin-glucuronate 5-epimerase activity IDA16505484


    DSE for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DSE:
     Increased HDAC inhibitor resis 

    Animal Models:
         Mouse knock-out Dsetm1Mmac for DSE
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dse):
     growth/size  integument  limbs/digits/tail  reproductive system 

    DSE for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DSE gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIIA - Sanfilippo syndrome A1.00
    		MPS I - Hurler syndrome1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		Mucopolysaccharidoses1.00
    		MPS IX - Natowicz syndrome1.00
    		MPS IV - Morquio syndrome A1.00
    		MPS II - Hunter syndrome1.00
    2dermatan sulfate biosynthesis
    		dermatan sulfate biosynthesis1.00
    		Glycosaminoglycan biosynthesis - chondroitin sulfate0.73
    3Disease
    		Disease1.00
    4Metabolism
    		Metabolism1.00
    5dermatan sulfate biosynthesis (late stages)
    		dermatan sulfate biosynthesis (late stages)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for DSE 
        dermatan sulfate biosynthesis (late stages)
    dermatan sulfate biosynthesis

    5/18        Reactome Pathways for DSE (see all 18)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Dermatan sulfate biosynthesis


    1         Kegg Pathway  (Kegg details for DSE):
        Glycosaminoglycan biosynthesis - chondroitin sulfate

    UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01
    Pathway: Glycan metabolism; chondroitin sulfate biosynthesis
    Pathway: Glycan metabolism; heparan sulfate biosynthesis


    DSE for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DSE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for DSE (ENSP000003321514) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCANENSP000003312104STRING: ENSP00000331210
    BGNENSP000003273364STRING: ENSP00000327336
    CHPFENSP000002437764STRING: ENSP00000243776
    CHST14ENSP000003072974STRING: ENSP00000307297
    CHST15ENSP000003339474STRING: ENSP00000333947
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0015012heparan sulfate proteoglycan biosynthetic process IEA--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0030206chondroitin sulfate biosynthetic process IEA--


    DSE for ontologies           About GeneDecksing



    Drugs & Compounds
    for DSE gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DSE

    5 HMDB Compounds for DSE    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    D-Glucuronic acidD-(+)-glucuronate (see all 15)6556-12-3--
    D-Glucurono-6,3-lactoneD-Glucurono-3,6-lactone (see all 18)32449-92-6--
    DermatanChondroitin sulfate B (see all 13)24967-94-0--
    Iduronic acidL-Iduronate (see all 3)3402-98-0--
    Search CenterWatch for drugs/clinical trials and news about DSE 

    Transcripts
    for DSE gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DSE gene (2 alternative transcripts): 
    NM_001080976.1  NM_013352.2  

    Unigene Cluster for DSE:

    Dermatan sulfate epimerase
    Hs.744135  [show with all ESTs]
    Unigene Representative Sequence: NM_003309
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430252(uc003pwq.1) ENST00000331677(uc011ebg.2 uc003pwt.3 uc003pwu.3)
    ENST00000540275(uc011ebf.1) ENST00000537543 ENST00000452085(uc003pws.3)
    ENST00000359564

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DSE
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DSE (see all 11):
    hsa-miR-4307 hsa-miR-3200-5p hsa-miR-448 hsa-miR-507 hsa-miR-587 hsa-miR-153 hsa-miR-9 hsa-miR-129-5p
    SwitchGear 3'UTR luciferase reporter plasmid: DSE 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DSE (see all 7)
    OriGene shRNA RFP: DSE
    OriGene siRNA: DSE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSE
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF098066.1 AK095123.1 AK293872.1 AK298559.1 AK301513.1 AK316303.1 AL832471.1 BC039245.1 
    BC043526.1 

    24/26 DOTS entries (see all 26):

    DT.95070676  DT.99947066  DT.309644  DT.99943305  DT.100060249  DT.87017105  DT.97870393  DT.100060251 
    DT.100803898  DT.91890461  DT.95115225  DT.100709181  DT.100742632  DT.317026  DT.40122462  DT.95233470 
    DT.100709193  DT.75130090  DT.100042463  DT.100703867  DT.121403371  DT.40277112  DT.95136696  DT.97805301 

    24/148 AceView cDNA sequences (see all 148):

    NM_013352 BX110619 AI569987 BI461157 BQ445872 AI927761 BX348375 AI087828 
    AI452787 AF098066 AI393799 AW628136 AA333245 BF982595 BQ020889 CF242815 
    AA665686 BC043526 AI492462 AI431774 AL599182 AI923929 BM479415 AK095123 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DSE    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
    SP1:              -     -     -     -     -                       -                     
    SP2:                                                              -                     
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for DSE

    Expression
    for DSE gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DSE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DSE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DSE

    SOURCE GeneReport for Unigene cluster: Hs.744135

    UniProtKB/Swiss-Prot: DSE_HUMAN, Q9UL01
    Tissue specificity: Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain,
    colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and
    adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some
    adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level)

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    In Situ
    Assay Products:     
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    Orthologs
    for DSE gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DSE gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dse1 , 5 dermatan sulfate epimerase1, 5 87.5(n)1
    93.94(a)1    		   10 (18.85 cM)5
    2128981  NM_172508.21  NP_766096.11 
     341513945 
    chicken
    (Gallus gallus)    		 Aves DSE1 dermatan sulfate epimerase 78.81(n)
    85.18(a)    		   421745  XM_419777.3  XP_419777.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DSE6
    		 --
    		 81(a)
    		 1 ↔ 1
    		 1(186236553-186255481)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.37102 Transcribed sequence with moderate similarity to protein more 77.81(n)    142005898 
    zebrafish
    (Danio rerio)    		 Actinopterygii dse1 dermatan sulfate epimerase 65.36(n)
    66.17(a)    		   568713  NM_001030225.1  NP_001025396.1 


    ENSEMBL Gene Tree for DSE (if available)
    TreeFam Gene Tree for DSE (if available) 

    Paralogs
    for DSE gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DSE gene
    DSEL2  
    1 SIMAP similar gene for DSE using alignment to 3 protein entries:     DSE_HUMAN (see all proteins):
    DSEL

    DSE for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for DSE (see all 9)
    PGOHUM00000259512 PGOHUM00000259674 PGOHUM00000259675 PGOHUM00000260410 PGOHUM00000260494


    Genomic Variants
    for DSE gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2397 NCBI SNPs in DSE are shown (see all 2397)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs802038391,2
    		F,--114271199(+) AAATAG/CAAGTG 1 -- ds50011Minor allele frequency- C:0.08WA 118
    rs93873991,2
    		H--114272228(+) TGCGGT/GTTCCT 1 -- nc-transcript-varianttrp34Minor allele frequency- G:0.00NS EA 418
    rs776134431,2
    		--114272784(+) CGAGCC/TGGGAA 1 -- nc-transcript-variant1Minor allele frequency- T:0.01NA 120
    rs613028521,2
    		--114273990(+) TTTCAC/TGCAAA 1 -- us2k10--------
    rs94816341,2
    		H,--114274596(+) agctgG/Tgcgtg 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs94889151,2
    		F,--114275041(+) CTGCCC/GTGAGA 1 -- us2k11Minor allele frequency- G:0.11WA 118
    rs1828239771,2
    		--116603402(+) AAAAGG/TAATAT 1 -- int10--------
    rs2012328571,2
    		--116603521(+) TCCTA-/TTTTTT 1 -- int10--------
    rs1874265101,2
    		--116603609(+) ATTAAC/TGTAAT 1 -- int10--------
    rs1429964811,2
    		C,--116603779(+) TTTGA-/ATATATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DSE (116575336 - 116759442 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for DSE
         1 CNV: 99676
         6 Indels: 40905 40904 62564 40903 46978 12857

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    Disorders / Diseases
    for DSE gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DSE for disorders           About GeneDecksing

    OMIM gene information: 605942    OMIM disorders: --

    12 diseases for DSE:    About MalaCards
    squamous cell carcinoma    carcinoma    cycloplegia    anisometropia
    amblyopia    hyperopia    astigmatism    renal cell carcinoma
    myopia    breast cancer    melanoma    adenocarcinoma

    6 diseases from the University of Copenhagen DISEASES database for DSE:
    Astigmatism     Myopia     Anisometropia     Hyperopia
    Amblyopia     Cycloplegia
    Human Genome Epidemiology (HuGE) Navigator: DSE (4 documents)

    Export disorders for DSE gene to outside databases

    Publications
    for DSE gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DSE gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with DSE)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5- epimerase is identical to SART2. (PubMed id 16505484)1, 2, 3 Maccarana M.... Malmstroem A. (2006)
    2. Expression of tumor rejection antigens in colorectal carcinomas. (PubMed id 11920522)1, 3, 9 Sasatomi T....Shirouzu K. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL. (PubMed id 10679095)1, 2 Nakao M....Itoh K. (2000)
    6. Expression of tumor-rejection antigens in gynecologic cancers. (PubMed id 11092984)1, 9 Tanaka S....Itoh K. (2000)
    7. Dermatan sulfate is involved in the tumorigenic proper ties of esophagus squamous cell carcinoma. (PubMed id 22350411)1 Thelin M.A....Malmstrom A. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function. (PubMed id 19004833)1 Pacheco B....MalmstrAPm L. (2009)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for DSE gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DSE gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29940 HGNC: 21144 AceView: SART2 Ensembl:ENSG00000111817 euGenes: HUgn29940
    ECgene: DSE Kegg: 29940 H-InvDB: DSE

    Other Databases showing DSE gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DSE gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DSE Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DSE gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DSE gene:
    Search GeneIP for patents involving DSE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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