|
|
Down syndrome critical region gene 9 (non-protein coding)
| |
Aliases
for DSCR9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 8
| Aliases |
|---|
| Down Syndrome Critical Region Gene 9 (Non-Protein Coding)1 2 | | NCRNA000381 2 |
| External Ids: | HGNC: 163011 | Entrez Gene: 2572032 | Ensembl: ENSG000002303667 | UniProtKB: P590203 | | ORGUL members: | |
|---|
| NONCODE:n377000 n386292 n376981 n386288 n378978 | see all 8 |
Export aliases for DSCR9 gene to outside databasesPrevious GC identifers: GC21P035170 GC21P037513 GC21P037502 GC21P024056
|---|
Summaries
for DSCR9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DSCR9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DSCR9 gene promoter:
AP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DSCR9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSCR9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.13 Ensembl cytogenetic band: 21q22.13 HGNC cytogenetic band: 21q22DSCR9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P038580: view genomic region
(about GC identifiers)
Start:
|
38,580,804 bp from pter |
End:
|
38,594,037 bp from pter |
Size:
|
13,234 bases |
Orientation:
|
plus strand |
ORGUL member locations:
Legend (see complete legend)
- n376999
- n377001
- n378978
- n386288
- n377000
- n376981
- n386292
- n380644
38580803 38587422 38594041 chr21
|
Proteins
for DSCR9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DSCR9_HUMAN, P59020 (See
protein sequence)Recommended Name: Down syndrome critical region protein 9 Size: 149 amino acids; 16743 Da
Secondary accessions: B2R8P8Explore the universe of human proteins at neXtProt for DSCR9: NX_P59020
DSCR9 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
DSCR9 for ontologies About GeneDecksing
DSCR9 Antibody Products:
Assay Products for DSCR9: |
Protein
Domains /
Families
for DSCR9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P59020 |
Function
for DSCR9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DSCR9
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DSCR9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for DSCR9 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DSCR9 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DSCR9 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
DSCR9 for ontologies About GeneDecksing
|
Pathways & Interactions
for DSCR9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DSCR9
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
DSCR9 for ontologies About GeneDecksing
|
Drugs & Compounds
for DSCR9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DSCR9
Search CenterWatch for drugs/clinical trials and news about DSCR9
|
Transcripts
for DSCR9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DSCR9 gene: NM_148675.3 Unigene Cluster for DSCR9: Down syndrome critical region gene 9 (non-protein coding) Hs.505159 [show with all ESTs]Unigene Representative Sequence: BC0666536 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000581640(lincRNA) ENST00000578829(lincRNA)(uc010gni.3) ENST00000585273(lincRNA)(uc010gng.3)
ENST00000584840(lincRNA)(uc010gnh.3) ENST00000454482(lincRNA)(uc010gnj.3 uc011aef.2)
ENST00000543267(lincRNA)(uc010gnk.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DSCR9
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DSCR9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for DSCR9 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DSCR9 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DSCR9 |
Additional cDNA sequence: AB066100.1 AB212286.1 AB212287.1 AB212288.1 AB212289.1 AB212290.1 AB212291.1 AK313458.1 BC029827.1 BC066653.1 NR_026719.2 1 DOTS entry: DT.210120 24/30 AceView cDNA sequences (see all 30): AB066100 AA973296 BF508967 CD673555 NM_148675 BQ223675 AI206596 AA432171 BC066653 AA256098 AA255898 AI419824 AI075910 AI291000 AI125524 AW510868 BC029827 AW295935 BI826306 AI918692 BF062278 AI125493 AW236642 AI631552
GeneLoc Exon Structure
|
Expression
for DSCR9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for DSCR9:NONCODE
DSCR9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCCCTGGG
About this image
Genevestigator expression for DSCR9
SOURCE GeneReport for Unigene cluster: Hs.505159
UniProtKB/Swiss-Prot: DSCR9_HUMAN, P59020Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for DSCR9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DSCR9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DSCR9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSCR9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSCR9 |
Orthologs
for DSCR9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DSCR9 (if available)
TreeFam Gene Tree for DSCR9 (if available) |
Paralogs
for DSCR9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DSCR9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DSCR9 (38580804 - 38594037 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DSCR9: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DSCR9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DSCR9 for disorders About GeneDecksing
2  diseases for DSCR9: About MalaCardsdown syndrome critical region down syndrome
Human Genome Epidemiology (HuGE) Navigator: DSCR9 (1 document)
Export disorders for DSCR9 gene to outside databases
|
Publications
for DSCR9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DSCR9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DSCR9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of two novel primate-specific genes in DSCR. (PubMed id 12168953)1, 2, 3 Takamatsu K....Takeda T. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Digital quantification of human eye color highlights genetic association of three new loci. (PubMed id 20463881)1 Liu F....Kayser M. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)2 Hattori M....Yaspo M.L. (2000)
|
External Searches for DSCR9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DSCR9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DSCR9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DSCR9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DSCR9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DSCR9 gene:
Search GeneIP for patents involving DSCR9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DSCR9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DSCR9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DSCR9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DSCR9 | | | OriGene Protein Over-expression Lysate for DSCR9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DSCR9 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DSCR9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DSCR9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DSCR9 | | OriGene Custom Protein Services for DSCR9 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DSCR9 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DSCR9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSCR9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSCR9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSCR9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSCR9 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DSCR9 |
| |  |  |  |  | | | | |
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 |
 |
 | | | DSCR9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for DSCR9 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DSCR9 |
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