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Aliases for DSCR8 Gene

Subcategory (RNA class) for DSCR8 Gene


Quality Score for this RNA gene is


Aliases for DSCR8 Gene

  • Down Syndrome Critical Region 8 2 3
  • Malignant Melanoma-Associated 1 2 3
  • C21orf65 3 4
  • MMA-1 3 4
  • MTAG2 3 4
  • MMA1 3 6
  • Cancer/Testis Antigen Family 25, Member 1a 3
  • Cancer/Testis Antigen Family 25, Member 1b 3
  • Malignant Melanoma Associated Protein 1 3
  • Malignant Melanoma-Associated Protein 1 4
  • Down Syndrome Critical Region Gene 8 3
  • Melanoma-Testis-Associated Protein 2 3
  • Chromosome 21 Open Reading Frame 65 2
  • Cancer/Testis Antigen Family 25 2
  • Cancer/Testis Antigen 25 4
  • Protein MTAG2 4
  • Member 1a 2
  • Member 1b 2
  • CT25.1a 3
  • CT25.1b 3
  • MMA-1a 3
  • MMA-1b 3
  • CT25 4

External Ids for DSCR8 Gene

ORGUL Members for DSCR8 Gene

Previous HGNC Symbols for DSCR8 Gene

  • C21orf65

Previous GeneCards Identifiers for DSCR8 Gene

  • GC21P036070
  • GC21P038413
  • GC21P038415
  • GC21P039493
  • GC21P024963

Summaries for DSCR8 Gene

GeneCards Summary for DSCR8 Gene

DSCR8 (Down Syndrome Critical Region 8) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DSCR8 include melanoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSCR8 Gene

Genomics for DSCR8 Gene

Regulatory Elements for DSCR8 Gene

Genomic Location for DSCR8 Gene

38,121,451 bp from pter
38,188,016 bp from pter
66,566 bases
Plus strand

Genomic View for DSCR8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DSCR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSCR8 Gene

Proteins for DSCR8 Gene

  • Protein details for DSCR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Down syndrome critical region protein 8
    Protein Accession:
    Secondary Accessions:
    • Q8N3X0
    • Q8NDY5
    • Q96B46

    Protein attributes for DSCR8 Gene

    97 amino acids
    Molecular mass:
    10969 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DSCR8 Gene


neXtProt entry for DSCR8 Gene

Proteomics data for DSCR8 Gene at MOPED

Post-translational modifications for DSCR8 Gene

No Post-translational modifications

Other Protein References for DSCR8 Gene

No data available for DME Specific Peptides for DSCR8 Gene

Domains for DSCR8 Gene

Protein Domains for DSCR8 Gene


Suggested Antigen Peptide Sequences for DSCR8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DSCR8: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DSCR8 Gene

Function for DSCR8 Gene

Gene Ontology (GO) - Molecular Function for DSCR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DSCR8: view

miRNA for DSCR8 Gene

miRTarBase miRNAs that target DSCR8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DSCR8 Gene

Localization for DSCR8 Gene

Subcellular locations from

Jensen Localization Image for DSCR8 Gene COMPARTMENTS Subcellular localization image for DSCR8 gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DSCR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with DSCR8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DSCR8 Gene

Pathways for DSCR8 Gene

SuperPathways for DSCR8 Gene

No Data Available

Interacting Proteins for DSCR8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350336 Q96T75-DSCR8_HUMAN for DSCR8 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for DSCR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DSCR8: view

No data available for Pathways by source for DSCR8 Gene

Transcripts for DSCR8 Gene

Unigene Clusters for DSCR8 Gene

Down syndrome critical region gene 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DSCR8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DSCR8 Gene

No ASD Table

Relevant External Links for DSCR8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DSCR8 Gene

mRNA expression in normal human tissues for DSCR8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DSCR8 Gene

This gene is overexpressed in Testis (51.6).

SOURCE GeneReport for Unigene cluster for DSCR8 Gene Hs.733345

mRNA Expression by UniProt/SwissProt for DSCR8 Gene

Tissue specificity: Expressed in numerous tissues; not found in breast, heart, small intestine and liver
genes like me logo Genes that share expressions with DSCR8: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for DSCR8 Gene

Orthologs for DSCR8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DSCR8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DSCR8 36
  • 100 (a)
Species with no ortholog for DSCR8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DSCR8 Gene

Gene Tree for DSCR8 (if available)
Gene Tree for DSCR8 (if available)

Paralogs for DSCR8 Gene

Selected SIMAP similar genes for DSCR8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DSCR8: view

No data available for Paralogs for DSCR8 Gene

Variants for DSCR8 Gene

Sequence variations from dbSNP and Humsavar for DSCR8 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs928767 -- 38,141,223(+) CTTCA(A/G)AAGTG intron-variant
rs928768 -- 38,141,644(+) TGATA(G/T)TTATA intron-variant
rs991015 -- 38,155,877(+) ATTTT(A/G)TGTTA intron-variant
rs1003610 -- 38,151,173(-) tcaca(G/T)actga intron-variant
rs1003611 -- 38,151,171(-) acata(C/T)tgagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DSCR8 Gene

Variant ID Type Subtype PubMed ID
nsv834097 CNV Gain 17160897
esv268329 CNV Insertion 20981092

Relevant External Links for DSCR8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSCR8 Gene

Disorders for DSCR8 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DSCR8 Gene in MalaCards »

(1) Diseases for DSCR8 Gene including...

(1) University of Copenhagen DISEASES for DSCR8 Gene

genes like me logo Genes that share disorders with DSCR8: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for DSCR8 Gene

Publications for DSCR8 Gene

  1. Nineteen additional unpredicted transcripts from human chromosome 21. (PMID: 12036297) Reymond A. … Antonarakis S.E. (Genomics 2002) 2 3 4
  2. Comparative genomic sequence analysis of the human chromosome 21 Down syndrome critical region. (PMID: 12213769) Toyoda A. … Hattori M. (Genome Res. 2002) 3 4
  3. The MMA1 gene family of cancer-testis antigens has multiple alternative splice variants: characterization of their expression profile, the genomic organization, and transcript properties. (PMID: 15472897) de Wit N.J. … van Muijen G.N. (Genes Chromosomes Cancer 2005) 3 23
  4. Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. (PMID: 9503011) Dahmane N. … Delabar J.-M. (Genomics 1998) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DSCR8 Gene

Sources for DSCR8 Gene

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