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DSCR3 Gene

protein-coding   GIFtS: 56
GCID: GC21M038591

Down Syndrome Critical Region Gene 3

  See DSCR3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Down Syndrome Critical Region Gene 31 2
Down Syndrome Critical Region Protein A2 3 11
DSCRA2 3 5
DCRA2 3
Down Syndrome Critical Region Protein 32

External Ids:    HGNC: 30441   Entrez Gene: 103112   Ensembl: ENSG000001575387   OMIM: 6052985   UniProtKB: O149723   

Export aliases for DSCR3 gene to outside databases

Previous GC identifers: GC21M035173 GC21M037516 GC21M037517 GC21M024071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DSCR3 Gene:
The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been
defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many
characteristics of Down syndrome, including morphological features, hypotonia, and mental retardation. The DSCR3
(Down syndrome critical region gene 3) gene is found in this region and is predictated to contain eight exons.
DSCR3 is expressed in most tissues examined. (provided by RefSeq, Jul 2008)

GeneCards Summary for DSCR3 Gene:
DSCR3 (Down syndrome critical region gene 3) is a protein-coding gene. Diseases associated with DSCR3 include down syndrome.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DSCR3 gene promoter:
         AhR   POU6F1 (c2)   c-Ets-1   CBF-C   Arnt   HEN1   NRF-2   CBF-B   CBF-A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDSCR3 promoter sequence

   Search Chromatin IP Primers for DSCR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DSCR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.13   HGNC cytogenetic band: 21q22.2
Nature(405: 311-319) cytogenetic band:   21q22.13
DSCR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSCR3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M038591:   GeneLoc Nature:405,311-319
Start:
38,595,721 bp from pter       24,172,248 bp from centromere
End:
38,640,262 bp from pter 24,216,356 bp from centromere
Size:
44,542 bases 44,109 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: D87343
genomic clones: pT1601 pD10


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DSCR3_HUMAN, O14972 (See protein sequence)
Recommended Name: Down syndrome critical region protein 3  
Size: 297 amino acids; 33010 Da
Secondary accessions: B2R6T8 D3DSH4 Q2TAY6

Explore the universe of human proteins at neXtProt for DSCR3: NX_O14972

Explore proteomics data for DSCR3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys149, Lys168, Lys175
  • Modification sites at PhosphoSitePlus

  • See DSCR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006043.1  
    ENSEMBL proteins: 
     ENSP00000311399   ENSP00000381967   ENSP00000419496   ENSP00000381964   ENSP00000440308  
     ENSP00000288304  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR014756 Ig_E-set

    Graphical View of Domain Structure for InterPro Entry O14972

    ProtoNet protein and cluster: O14972

    1 Blocks protein domain: IPB005377 Vacuolar protein sorting-associated protein 26

    UniProtKB/Swiss-Prot: DSCR3_HUMAN, O14972
    Similarity: Belongs to the VPS26 family


    Find genes that share domains with DSCR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with DSCR3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DSCR3:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DSCR3
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    miRNA
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    miRTarBase miRNAs that target DSCR3:
    hsa-mir-335-5p (MIRT017966), hsa-mir-877-5p (MIRT037229)

    Block miRNA regulation of human, mouse, rat DSCR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DSCR3 (see all 14):
    hsa-miR-3942-5p hsa-miR-15a hsa-miR-497 hsa-miR-373* hsa-miR-4314 hsa-miR-424 hsa-miR-298 hsa-miR-3920
    SwitchGear 3'UTR luciferase reporter plasmidDSCR3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DSCR3

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSCR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endosome1
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16780588
    GO:0030904retromer complex ----

    Find genes that share ontologies with DSCR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DSCR3
    Interactions:

        Search GeneGlobe Interaction Network for DSCR3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for DSCR3 (O149722, 3 ENSP000003113994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261021 I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    VPS26AENSP000002635594STRING: ENSP00000263559
    VPS26BENSP000002811874STRING: ENSP00000281187
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007034vacuolar transport ----
    GO:0008150biological_process ND--

    Find genes that share ontologies with DSCR3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DSCR3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DSCR3 gene: 
    NM_006052.1  

    Unigene Cluster for DSCR3:

    Down syndrome critical region gene 3
    Hs.369488  [show with all ESTs]
    Unigene Representative Sequence: AK126461
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497493 ENST00000309117(uc002ywf.1 uc010gnn.1 uc010gnl.2 uc011aeg.1 uc011aeh.1)
    ENST00000399000(uc010gnm.1) ENST00000399001 ENST00000476950 ENST00000488368
    ENST00000398998 ENST00000495858 ENST00000480452 ENST00000475009 ENST00000492514
    ENST00000462467 ENST00000498789 ENST00000539844 ENST00000288304
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DSCR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DSCR3 (see all 14):
    hsa-miR-3942-5p hsa-miR-15a hsa-miR-497 hsa-miR-373* hsa-miR-4314 hsa-miR-424 hsa-miR-298 hsa-miR-3920
    SwitchGear 3'UTR luciferase reporter plasmidDSCR3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DSCR3
    Predesigned siRNA for gene silencing in human, mouse, rat DSCR3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSCR3
    Primer
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    OriGene qPCR primer pairs and template standards for DSCR3
    OriGene qSTAR qPCR primer pairs in human, mouse for DSCR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DSCR3
      QuantiTect SYBR Green Assays in human, mouse, rat DSCR3
      QuantiFast Probe-based Assays in human, mouse, rat DSCR3

    Additional mRNA sequence: 

    AJ001867.1 AK126461.1 AK299662.1 AK300024.1 AK303624.1 AK307465.1 AK312707.1 AK316460.1 
    BC110655.1 BX648191.1 D87343.1 

    16 DOTS entries:

    DT.95273201  DT.75171696  DT.210120  DT.121130425  DT.100671766  DT.86853271  DT.101963742  DT.97835601 
    DT.121130466  DT.92432029  DT.92432030  DT.95273200  DT.97777539  DT.100671765  DT.403724  DT.97800328 

    Selected AceView cDNA sequences (see all 215):

    BE042910 AI049665 AA234900 BG541791 AL703854 BX954873 AL602716 CB113178 
    BU844970 AI635374 BM676205 AW613396 BU557228 AU125535 NM_006052 CR624431 
    BQ017976 AU131575 BM856374 AA303429 CA442968 BU629409 AI269171 AU127307 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DSCR3 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                                                                                -           -                                       
    SP2:                                                  -                             -           -                                       
    SP3:                                                  -                             -     -     -                                       
    SP4:                                                  -     -     -                 -           -                                       
    SP5:                                                  -     -     -     -     -     -     -     -                                       


    ECgene alternative splicing isoforms for DSCR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DSCR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTAATAA
    DSCR3 Expression
    About this image


    DSCR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Thymus (Hematopoietic System)
    DSCR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DSCR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369488

    UniProtKB/Swiss-Prot: DSCR3_HUMAN, O14972
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSCR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DSCR3 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dscr31 , 5 Down syndrome critical region gene 31, 5 85.25(n)1
    91.89(a)1
      16 (55.23 cM)5
    131851  NM_007834.31  NP_031860.11 
     944977835 
    chicken
    (Gallus gallus)
    Aves DSCR31 Down syndrome critical region gene 3 80.36(n)
    91.92(a)
      418519  XM_416728.3  XP_416728.1 
    lizard
    (Anolis carolinensis)
    Reptilia DSCR36
    Down syndrome critical region gene 3
    73(a)
    1 ↔ 1
    3(140822926-140900385)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.71032 Xenopus laevis transcribed sequence with moderate similarity more 78.14(n)    BX853083.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dscr31 Down syndrome critical region gene 3 71.49(n)
    77.78(a)
      445026  NM_001003421.1  NP_001003421.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40741 , 3 CG40741 49(a)3
    54.47(n)1
    50.72(a)1
      77E63
    402901  NM_140992.31  NP_649249.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G485501 AT1G48550 50.8(n)
    43.91(a)
      841276  NM_103751.2  NP_175288.1 


    ENSEMBL Gene Tree for DSCR3 (if available)
    TreeFam Gene Tree for DSCR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DSCR3 gene

    Find genes that share paralogs with DSCR3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DSCR3
    PGOHUM00000240503


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DSCR3 (see all 958)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117022271,2
    H--29142813(+) ttgtaC/Gatatg 1 -- ds50010--------
    rs1439211061,2
    --29142887(+) GCTCTA/CATTGG 1 -- ds50010--------
    rs1906145401,2
    --29142945(+) GCAAGC/GCTGGG 1 -- ds50010--------
    rs1817139551,2
    --29142950(+) CCTGGA/GCAAGA 1 -- ds50010--------
    rs1863749091,2
    --29142989(+) AACATC/GTGAGT 1 -- ds50010--------
    rs1912824781,2
    --29143050(+) TGGCCA/GGCCTG 1 -- ds50010--------
    rs1826306571,2
    --29143108(+) CCACGC/TTGTCT 1 -- ds50010--------
    rs31651,2
    C,F,A,H--29143348(-) TATCTA/GTCCTT 1 -- ut3116Minor allele frequency- G:0.21MN NA NS EA WA 1292
    rs1506330471,2
    C--29143382(+) GGAGAC/TTATAA 1 -- ut310--------
    rs743371741,2
    C,F--29143498(+) TTACCC/TTTGGC 1 -- ut312Minor allele frequency- T:0.03WA NA 238

    HapMap Linkage Disequilibrium report for DSCR3 (38595721 - 38640262 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DSCR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2625731CNV Deletion19546169
    dgv70n68CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DSCR3
    DNA2.0 Custom Variant and Variant Library Synthesis for DSCR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605298    OMIM disorders: --

    1 disease for DSCR3:    
    About MalaCards
    down syndrome

    1 disease from the University of Copenhagen DISEASES database for DSCR3:
    Down syndrome

    Find genes that share disorders with DSCR3           About GenesLikeMe

    Genetic Association Database (GAD): DSCR3

    Export disorders for DSCR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DSCR3 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with DSCR3)
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    1. Isolation of a novel human gene from the Down syndrome critical region of chromosome 21q22.2. (PubMed id 9399594)1, 2, 3 Nakamura A.... Sakaki Y. (J. Biochem. 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10311 HGNC: 3044 AceView: DSCR3 Ensembl:ENSG00000157538 euGenes: HUgn10311
    ECgene: DSCR3 H-InvDB: DSCR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DSCR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DSCR3 gene:
    Search GeneIP for patents involving DSCR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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