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Down syndrome critical region gene 10 (non-protein coding)(Previous name: Down syndrome critical region gene 10 )
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Aliases
for DSCR10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| Down Syndrome Critical Region Gene 10 (Non-Protein Coding)1 2 | | Down Syndrome Critical Region Gene 101 |
| External Ids: | HGNC: 163021 | Entrez Gene: 2592342 | Ensembl: ENSG000002333167 | UniProtKB: P590223 | | ORGUL members: | |
|---|
| NONCODE:n386297 | |
Export aliases for DSCR10 gene to outside databasesPrevious GC identifers: GC21U990114 GC21P036238 GC21P038498 GC21P038500 GC21P025047
|---|
Summaries
for DSCR10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DSCR10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DSCR10 gene promoter:
c-Fos AP-1 POU6F1 (c2) C/EBPalpha RORalpha1 NF-AT4 NF-AT2 NF-AT3 c-Jun NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DSCR10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSCR10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.13 Ensembl cytogenetic band: 21q22.13 HGNC cytogenetic band: 21q22.13DSCR10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P039578: view genomic region
(about GC identifiers)
Start:
|
39,578,250 bp from pter |
End:
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39,580,738 bp from pter |
Size:
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2,489 bases |
Orientation:
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plus strand |
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Proteins
for DSCR10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DSC10_HUMAN, P59022 (See
protein sequence)Recommended Name: Down syndrome critical region protein 10 Size: 87 amino acids; 9286 Da
Secondary accessions: Q52LN2Explore the universe of human proteins at neXtProt for DSCR10: NX_P59022
DSCR10 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
DSCR10 for ontologies About GeneDecksing
DSCR10 Antibody Products:
Assay Products for DSCR10: |
Protein
Domains /
Families
for DSCR10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P59022 |
Function
for DSCR10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSCR10 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
DSCR10 for ontologies About GeneDecksing
|
Pathways & Interactions
for DSCR10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DSCR10
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
DSCR10 for ontologies About GeneDecksing
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Drugs & Compounds
for DSCR10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DSCR10
Search CenterWatch for drugs/clinical trials and news about DSCR10 
|
Transcripts
for DSCR10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DSCR10 gene: NM_148676.2 Unigene Cluster for DSCR10: Down syndrome critical region gene 10 (non-protein coding) Hs.147695 [show with all ESTs]Unigene Representative Sequence: AB0662912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000432141(lincRNA)(uc010gnt.2) ENST00000538415(lincRNA)
Additional cDNA sequence: AB066291.1 BC093855.1 NR_027695.1 1 DOTS entry: DT.100016359 5 AceView cDNA sequences: BX115939 AI219658 AB066291 NM_148676 AW663423
GeneLoc Exon Structure
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Expression
for DSCR10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for DSCR10:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
Genevestigator expression for DSCR10
SOURCE GeneReport for Unigene cluster: Hs.147695
UniProtKB/Swiss-Prot: DSC10_HUMAN, P59022Tissue specificity: Expressed in placenta and testis
SABiosciences Custom PCR Arrays for DSCR10
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DSCR10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DSCR10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSCR10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSCR10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSCR10 |
Orthologs
for DSCR10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DSCR10 (if available)
TreeFam Gene Tree for DSCR10 (if available) |
Paralogs
for DSCR10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DSCR10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DSCR10 (39578250 - 39580738 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DSCR10: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for DSCR10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DSCR10 for disorders About GeneDecksing
3  diseases for DSCR10: About MalaCardsdown syndrome critical region down syndrome atherosclerosis
Human Genome Epidemiology (HuGE) Navigator: DSCR10 (1 document)
Export disorders for DSCR10 gene to outside databases
|
Publications
for DSCR10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DSCR10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DSCR10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of two novel primate-specific genes in DSCR. (PubMed id 12168953)1, 2, 3 Takamatsu K....Takeda T. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1 Wang Y....Huang W. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DSCR10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DSCR10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DSCR10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DSCR10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DSCR10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DSCR10 gene:
Search GeneIP for patents involving DSCR10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DSCR10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DSCR10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DSCR10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DSCR10 | | | OriGene Protein Over-expression Lysate for DSCR10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DSCR10 | | Browse 3'-UTR reporter clones for miRNA target validation | | | Browse OriGene untagged cDNA clones in CMV expression vector | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DSCR10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DSCR10 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DSCR10 | | OriGene Custom Protein Services for DSCR10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DSCR10 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DSCR10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSCR10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSCR10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSCR10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSCR10 |
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 |  |  |  | |
| | | | Search Tocris compounds for DSCR10 |
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 | | | DSCR10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSCR10 |
|  |  |  | | | | Search ThermoFisher Antibodies for DSCR10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSCR10 |
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