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DSCC1 Gene

protein-coding   GIFtS: 50
GCID: GC08M120846

DNA Replication And Sister Chromatid Cohesion 1

(Previous name: defective in sister chromatid cohesion 1 homolog (S. cerevisiae))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DNA Replication And Sister Chromatid Cohesion 11 2     Defective In Sister Chromatid Cohesion Homolog 1 (S. Cerevisiae)1
DCC12 3 5     Defective In Sister Chromatid Cohesion 1 Homolog2
Defective In Sister Chromatid Cohesion Protein 1 Homolog2 3     Sister Chromatid Cohesion Protein DCC12
Defective In Sister Chromatid Cohesion 1 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 244531   Entrez Gene: 790752   Ensembl: ENSG000001369827   OMIM: 6132035   UniProtKB: Q9BVC33   

Export aliases for DSCC1 gene to outside databases

Previous GC identifers: GC08M120916 GC08M120917 GC08M116167


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DSCC1 Gene:
CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC)
(see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al.,
2003 (PubMed 12766176); Bermudez et al., 2003 (PubMed 12930902)).(supplied by OMIM, Dec 2009)

GeneCards Summary for DSCC1 Gene:
DSCC1 (DNA replication and sister chromatid cohesion 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: DCC1_HUMAN, Q9BVC3
Function: Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks.
May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin
subunit SMC3

Gene Wiki entry for DSCC1 (DCC1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DSCC1 gene promoter:
         SRF   Sp1   GATA-3   SRF (504 AA)   Nkx2-5   GATA-2   GATA-1   POU2F1   COMP1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDSCC1 promoter sequence
   Search Chromatin IP Primers for DSCC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DSCC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.12   Ensembl cytogenetic band:  8q24.12   HGNC cytogenetic band: 8q24.12

DSCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DSCC1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M120846:  view genomic region     (about GC identifiers)

Start:
120,846,181 bp from pter      End:
120,868,250 bp from pter
Size:
22,070 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DCC1_HUMAN, Q9BVC3 (See protein sequence)
Recommended Name: Sister chromatid cohesion protein DCC1  
Size: 393 amino acids; 44825 Da
Subunit: Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts
with CTF8 and CTF18
Secondary accessions: Q969N5

Explore the universe of human proteins at neXtProt for DSCC1: NX_Q9BVC3

Explore proteomics data for DSCC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DSCC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076999.2  
    ENSEMBL proteins: 
     ENSP00000322180  

    DSCC1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DSCC1

     
    Search eBioscience for Proteins for DSCC1 

     
    antibodies-online proteins for DSCC1 (3 products) 

     
    antibodies-online peptides for DSCC1

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    antibodies-online antibodies for DSCC1 (22 products) 

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    Cloud-Clone Corp. ELISAs for DSCC1
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    antibodies-online kits for DSCC1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019128 Sister_chromatid_cohesion_Dcc1

    Graphical View of Domain Structure for InterPro Entry Q9BVC3

    ProtoNet protein and cluster: Q9BVC3

    UniProtKB/Swiss-Prot: DCC1_HUMAN, Q9BVC3
    Similarity: Belongs to the DCC1 family


    Find genes that share domains with DSCC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCC1_HUMAN, Q9BVC3
    Function: Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks.
    May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin
    subunit SMC3

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16682347
         
    Find genes that share ontologies with DSCC1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dscc1):
     cellular  mortality/aging  skeleton 

    Find genes that share phenotypes with DSCC1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DSCC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DSCC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DSCC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DSCC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DSCC1:
    hsa-mir-26b-5p (MIRT029497), hsa-mir-193b-3p (MIRT016470)

    Block miRNA regulation of human, mouse, rat DSCC1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate DSCC1:
    hsa-miR-3163 hsa-miR-539 hsa-miR-891b hsa-miR-3143 hsa-miR-708* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidDSCC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DSCC1
    Predesigned siRNA for gene silencing in human, mouse, rat DSCC1

    Gene Editing
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    OriGene ORF clones in mouse, rat for DSCC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DSCC1 (NM_024094)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DSCC1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSCC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCC1_HUMAN, Q9BVC3: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA16682347
    GO:0000785chromatin IDA16682347
    GO:0005654nucleoplasm IDA16682347

    Find genes that share ontologies with DSCC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DSCC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Gastric cancer network 2
    Gastric cancer network 2


    1 BioSystems Pathway for DSCC1
        Gastric cancer network 2


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DSCC1
    Interactions:

        Search GeneGlobe Interaction Network for DSCC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DSCC1 (Q9BVC33 ENSP000003221804) via UniProtKB, MINT, STRING, and/or I2D (see all 190)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    CHTF18Q8WVB63, ENSP000002623154I2D: score=1 STRING: ENSP00000262315
    CHTF8P0CG133, ENSP000003812904I2D: score=1 STRING: ENSP00000381290
    DDX11Q96FC93, ENSP000003847034I2D: score=1 STRING: ENSP00000384703
    RFC2P352503, ENSP000000550774I2D: score=1 STRING: ENSP00000055077
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006275regulation of DNA replication IMP19907496
    GO:0034088maintenance of mitotic sister chromatid cohesion IMP16682347
    GO:0034421post-translational protein acetylation IMP19907496

    Find genes that share ontologies with DSCC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DSCC1 (DCC1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DSCC1 gene: 
    NM_024094.2  

    Unigene Cluster for DSCC1:

    Defective in sister chromatid cohesion 1 homolog (S. cerevisiae)
    Hs.315167  [show with all ESTs]
    Unigene Representative Sequence: NM_024094
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313655(uc003yov.3) ENST00000521795
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DSCC1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate DSCC1:
    hsa-miR-3163 hsa-miR-539 hsa-miR-891b hsa-miR-3143 hsa-miR-708* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidDSCC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DSCC1
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    GenScript: all cDNA clones in your preferred vector: DSCC1 (NM_024094)
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    Primer
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    OriGene qPCR primer pairs and template standards for DSCC1
    OriGene qSTAR qPCR primer pairs in human, mouse for DSCC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DSCC1
      QuantiTect SYBR Green Assays in human, mouse, rat DSCC1
      QuantiFast Probe-based Assays in human, mouse, rat DSCC1

    Additional mRNA sequence: 

    AK054585.1 AK058129.1 AK074355.1 AK315356.1 AY358866.1 BC001316.1 BC001531.2 

    3 DOTS entries:

    DT.107526  DT.100774470  DT.120641799 

    Selected AceView cDNA sequences (see all 85):

    AA541258 BQ433155 AK054585 BF983623 AW389492 CA395067 AY358866 AI912390 
    BQ439963 BM824620 AA514054 BM836598 BM826953 BX342226 BC001531 CR614540 
    BC001316 AA906469 BP872824 BF212205 AA179823 AA101303 BI752896 BM789698 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DSCC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCTTTGGGA
    DSCC1 Expression
    About this image


    DSCC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Ventricular Zone
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    DSCC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DSCC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.315167
        Custom PCR Arrays for DSCC1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSCC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DSCC1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dscc11 , 5 defective in sister chromatid cohesion 1 homolog (S. more1, 5 84.1(n)1
    85.71(a)1
      15 (21.96 cM)5
    721071  NM_183089.21  NP_898912.21 
     550760995 
    chicken
    (Gallus gallus)
    Aves DSCC11 defective in sister chromatid cohesion 1 homolog (S. more 75.17(n)
    77.84(a)
      420358  XM_004940016.1  XP_004940073.1 
    lizard
    (Anolis carolinensis)
    Reptilia DSCC16
    DNA replication and sister chromatid cohesion 1
    73(a)
    1 ↔ 1
    GL343269.1(1098198-1108048)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.100042 Xenopus laevis transcribed sequence with moderate similarity more 73.12(n)    BX845466.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dscc11 defective in sister chromatid cohesion 1 homolog (S. more 67.53(n)
    67.78(a)
      447872  NM_001004611.1  NP_001004611.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117881 CG11788 41.94(n)
    30.38(a)
      37295  NM_137622.2  NP_611466.2 
    worm
    (Caenorhabditis elegans)
    Secernentea K09H9.21 K09H9.2 41.67(n)
    25.94(a)
      171887  NM_058708.6  NP_491109.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G445801 AT2G44580 45.27(n)
    32.25(a)
      819066  NM_130022.2  NP_181986.2 
    rice
    (Oryza sativa)
    Liliopsida Os05g01196001 Os05g0119600 43.65(n)
    33.09(a)
      4337640  NM_001061020.1  NP_001054485.1 


    ENSEMBL Gene Tree for DSCC1 (if available)
    TreeFam Gene Tree for DSCC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DSCC1 (see all 487)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10551331,2
    C,F,O,A,H--120847078(-) GGATAC/GAAGAA 1 -- ut31 ese3 trp321Minor allele frequency- G:0.45MN NS EA NA WA CSA 1124
    rs10551311,2
    C,F,O,A,H--120847123(-) ACAACA/GGTCTT 1 -- ut31 ese332Minor allele frequency- G:0.47MN NA NS EA WA CSA 3026
    rs2017723171,2
    --120847181(+) TGCATC/TGAAGA 2 S syn10--------
    rs10551301,2,,4
    C,F,O,A,H--120847188(-) TTCTCG/ATTCTT 2 /H /R mis139Minor allele frequency- A:0.31MN NS EA NA WA CSA EU 9550
    rs1445501241,2
    C,F--120847222(+) GGTTTG/TCTTCT 2 K Q mis12Minor allele frequency- T:0.00NA EU 5841
    rs1146396091,2
    F--120847353(+) CAAGCG/ATAAGT 1 -- int11Minor allele frequency- A:0.01WA 118
    rs69987711,2
    C,F--120847387(+) GGTGGG/AGAGTG 1 -- int12Minor allele frequency- A:0.03WA NA 238
    rs1409257791,2
    C--120847471(+) GGCCAA/GGCGGG 1 -- int10--------
    rs1445757691,2
    --120847485(+) CTCACA/GCCTGT 1 -- int10--------
    rs1871702131,2
    --120847636(+) CAGCTA/GCTTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for DSCC1 (120846181 - 120868250 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DSCC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv891418CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DSCC1
    DNA2.0 Custom Variant and Variant Library Synthesis for DSCC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613203    OMIM disorders: --


    Find genes that share disorders with DSCC1           About GenesLikeMe


    Export disorders for DSCC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DSCC1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DSCC1)
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    1. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. (PubMed id 12766176)1, 2, 3 Merkle C.J.... Chen J. (J. Biol. Chem. 2003)
    2. Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8. (PubMed id 20826785)1, 3 Murakami T....Tsurimoto T. (J. Biol. Chem. 2010)
    3. Cohesin acetylation speeds the replication fork. (PubMed id 19907496)1, 2 Terret M.E.... Jallepalli P.V. (Nature 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. (PubMed id 18499658)1 Farina A....Hurwitz J. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79075 HGNC: 24453 AceView: DCC1 Ensembl:ENSG00000136982 euGenes: HUgn79075
    ECgene: DSCC1 H-InvDB: DSCC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DSCC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DSCC1 gene:
    Search GeneIP for patents involving DSCC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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