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Aliases for DSCC1 Gene

Aliases for DSCC1 Gene

  • DNA Replication And Sister Chromatid Cohesion 1 2 3
  • DCC1 3 4 6
  • Defective In Sister Chromatid Cohesion Protein 1 Homolog 3 4
  • Defective In Sister Chromatid Cohesion Homolog 1 (S. Cerevisiae) 2
  • Defective In Sister Chromatid Cohesion 1 Homolog (S. Cerevisiae) 2
  • Defective In Sister Chromatid Cohesion 1 Homolog 3
  • Sister Chromatid Cohesion Protein DCC1 3

External Ids for DSCC1 Gene

Summaries for DSCC1 Gene

Entrez Gene Summary for DSCC1 Gene

  • CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DSCC1 Gene

DSCC1 (DNA Replication And Sister Chromatid Cohesion 1) is a Protein Coding gene. Among its related pathways are Gastric cancer network 2.

UniProtKB/Swiss-Prot for DSCC1 Gene

  • Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

Gene Wiki entry for DSCC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSCC1 Gene

Genomics for DSCC1 Gene

Genomic Location for DSCC1 Gene

Start:
119,833,941 bp from pter
End:
119,856,010 bp from pter
Size:
22,070 bases
Orientation:
Minus strand

Genomic View for DSCC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DSCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSCC1 Gene

Regulatory Elements for DSCC1 Gene

Proteins for DSCC1 Gene

  • Protein details for DSCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVC3-DCC1_HUMAN
    Recommended name:
    Sister chromatid cohesion protein DCC1
    Protein Accession:
    Q9BVC3
    Secondary Accessions:
    • Q969N5

    Protein attributes for DSCC1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44825 Da
    Quaternary structure:
    • Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18.

neXtProt entry for DSCC1 Gene

Proteomics data for DSCC1 Gene at MOPED

Post-translational modifications for DSCC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DSCC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DSCC1 Gene

Domains for DSCC1 Gene

Protein Domains for DSCC1 Gene

UniProtKB/Swiss-Prot:

DCC1_HUMAN
Family:
  • Belongs to the DCC1 family.:
    • Q9BVC3
genes like me logo Genes that share domains with DSCC1: view

No data available for Gene Families for DSCC1 Gene

Function for DSCC1 Gene

Molecular function for DSCC1 Gene

UniProtKB/Swiss-Prot Function: Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

Gene Ontology (GO) - Molecular Function for DSCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003689 contributes_to DNA clamp loader activity IBA --
GO:0005515 protein binding IPI 16682347
genes like me logo Genes that share ontologies with DSCC1: view

Phenotypes for DSCC1 Gene

genes like me logo Genes that share phenotypes with DSCC1: view

miRNA for DSCC1 Gene

miRTarBase miRNAs that target DSCC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DSCC1 Gene

Localization for DSCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DSCC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DSCC1 Gene COMPARTMENTS Subcellular localization image for DSCC1 gene
Compartment Confidence
nucleus 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DSCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 16682347
GO:0000785 chromatin IDA 16682347
GO:0005654 nucleoplasm IDA 16682347
GO:0031390 Ctf18 RFC-like complex IBA --
genes like me logo Genes that share ontologies with DSCC1: view

Pathways for DSCC1 Gene

SuperPathways for DSCC1 Gene

Superpath Contained pathways
1 Gastric cancer network 2
genes like me logo Genes that share pathways with DSCC1: view

Pathways by source for DSCC1 Gene

1 BioSystems pathway for DSCC1 Gene

Gene Ontology (GO) - Biological Process for DSCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006275 regulation of DNA replication IMP 19907496
GO:0034088 maintenance of mitotic sister chromatid cohesion IMP 16682347
GO:0034421 post-translational protein acetylation IMP 19907496
genes like me logo Genes that share ontologies with DSCC1: view

Transcripts for DSCC1 Gene

mRNA/cDNA for DSCC1 Gene

Unigene Clusters for DSCC1 Gene

Defective in sister chromatid cohesion 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DSCC1 Gene

No ASD Table

Relevant External Links for DSCC1 Gene

GeneLoc Exon Structure for
DSCC1
ECgene alternative splicing isoforms for
DSCC1

Expression for DSCC1 Gene

mRNA expression in normal human tissues for DSCC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DSCC1 Gene

SOURCE GeneReport for Unigene cluster for DSCC1 Gene Hs.315167

genes like me logo Genes that share expressions with DSCC1: view

Orthologs for DSCC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DSCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DSCC1 36
  • 99.38 (n)
  • 99.08 (a)
DSCC1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DSCC1 36
  • 88.35 (n)
  • 88.43 (a)
DSCC1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DSCC1 36
  • 91.67 (n)
  • 92.86 (a)
DSCC1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dscc1 36
  • 84.1 (n)
  • 85.71 (a)
Dscc1 16
Dscc1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DSCC1 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DSCC1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dscc1 36
  • 85.88 (n)
  • 88.52 (a)
chicken
(Gallus gallus)
Aves DSCC1 36
  • 75.17 (n)
  • 77.84 (a)
DSCC1 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DSCC1 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10004 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dscc1 36
  • 68.38 (n)
  • 71.47 (a)
Str.4502 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13927 36
zebrafish
(Danio rerio)
Actinopterygii dscc1 36
  • 67.53 (n)
  • 67.78 (a)
dscc1 37
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010703 36
  • 43.42 (n)
  • 28.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11788 36
  • 41.94 (n)
  • 30.38 (a)
CG11788 37
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K09H9.2 36
  • 41.67 (n)
  • 25.94 (a)
K09H9.2 37
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCC1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G44580 36
  • 45.27 (n)
  • 32.25 (a)
rice
(Oryza sativa)
Liliopsida Os05g0119600 36
  • 43.65 (n)
  • 33.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.825 37
  • 41 (a)
OneToOne
Species with no ortholog for DSCC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DSCC1 Gene

ENSEMBL:
Gene Tree for DSCC1 (if available)
TreeFam:
Gene Tree for DSCC1 (if available)

Paralogs for DSCC1 Gene

No data available for Paralogs for DSCC1 Gene

Variants for DSCC1 Gene

Sequence variations from dbSNP and Humsavar for DSCC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1048595 -- 119,854,373(+) TAATT(C/T)TCCTG intron-variant
rs1055130 - 119,834,948(-) TTCTC(A/G)TTCTT reference, missense
rs1055131 -- 119,834,883(-) ACAAC(A/G)GTCTT utr-variant-3-prime
rs1509347 -- 119,854,708(-) TGTGA(A/G)GACTT intron-variant
rs1828238 -- 119,848,105(-) cacct(C/G)tagtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DSCC1 Gene

Variant ID Type Subtype PubMed ID
nsv891418 CNV Gain 21882294

Relevant External Links for DSCC1 Gene

HapMap Linkage Disequilibrium report
DSCC1

Disorders for DSCC1 Gene

No disorders were found for DSCC1 Gene.

No data available for UniProtKB/Swiss-Prot for DSCC1 Gene

Publications for DSCC1 Gene

  1. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. (PMID: 12766176) Merkle C.J. … Chen J. (J. Biol. Chem. 2003) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Cohesin acetylation speeds the replication fork. (PMID: 19907496) Terret M.E. … Jallepalli P.V. (Nature 2009) 3 4
  5. Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8. (PMID: 20826785) Murakami T. … Tsurimoto T. (J. Biol. Chem. 2010) 2 3

Products for DSCC1 Gene

Sources for DSCC1 Gene

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