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Aliases for DSCC1 Gene

Aliases for DSCC1 Gene

  • DNA Replication And Sister Chromatid Cohesion 1 2 3 5
  • Defective In Sister Chromatid Cohesion Protein 1 Homolog 3 4
  • DCC1 3 4
  • Defective In Sister Chromatid Cohesion Homolog 1 (S. Cerevisiae) 2
  • Defective In Sister Chromatid Cohesion 1 Homolog (S. Cerevisiae) 2
  • Defective In Sister Chromatid Cohesion 1 Homolog 3
  • Sister Chromatid Cohesion Protein DCC1 3

External Ids for DSCC1 Gene

Previous GeneCards Identifiers for DSCC1 Gene

  • GC08M120916
  • GC08M120917
  • GC08M120846
  • GC08M116167

Summaries for DSCC1 Gene

Entrez Gene Summary for DSCC1 Gene

  • CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DSCC1 Gene

DSCC1 (DNA Replication And Sister Chromatid Cohesion 1) is a Protein Coding gene. Among its related pathways are Gastric cancer network 2. GO annotations related to this gene include DNA clamp loader activity.

UniProtKB/Swiss-Prot for DSCC1 Gene

  • Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

Gene Wiki entry for DSCC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSCC1 Gene

Genomics for DSCC1 Gene

Regulatory Elements for DSCC1 Gene

Enhancers for DSCC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F119854 0.6 ENCODE 66.3 -0.1 -90 2.5 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 ZNF143 DSCC1 TAF2 RN7SL396P
GH08F119866 1 Ensembl ENCODE 38.2 -11.3 -11285 1.2 GTF2F1 CTCF PKNOX1 MAX CEBPG RAD21 RFX5 GLIS2 SMC3 PRDM10 DSCC1 COL14A1 TAF2 RN7SL396P DEPTOR
GH08F119873 0.9 ENCODE 34.1 -18.3 -18338 2.5 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF143 DSCC1 COL14A1 ENSG00000245330 DEPTOR
GH08F119892 1.2 Ensembl ENCODE 32.4 -37.1 -37120 2.0 ZNF680 MAFG MAFF ZNF316 FOS FOXP2 PRDM10 MAFK EMSY DSCC1 ENSG00000245330 COL14A1 TAF2 GC08M119893 RNA5SP277 PIR41964
GH08F119831 0.2 ENCODE 29.4 +23.1 23147 2.2 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 DSCC1 TAF2 LOC105375728 RN7SKP153
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DSCC1 on UCSC Golden Path with GeneCards custom track

Promoters for DSCC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001400040 510 2601 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 ZNF143 SP3

Genomic Location for DSCC1 Gene

Chromosome:
8
Start:
119,833,941 bp from pter
End:
119,856,010 bp from pter
Size:
22,070 bases
Orientation:
Minus strand

Genomic View for DSCC1 Gene

Genes around DSCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DSCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DSCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSCC1 Gene

Proteins for DSCC1 Gene

  • Protein details for DSCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVC3-DCC1_HUMAN
    Recommended name:
    Sister chromatid cohesion protein DCC1
    Protein Accession:
    Q9BVC3
    Secondary Accessions:
    • Q969N5

    Protein attributes for DSCC1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44825 Da
    Quaternary structure:
    • Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex (PubMed:12766176). Interacts with CTF8 and CTF18 (PubMed:12766176). Interacts with DDX11 (PubMed:18499658).

neXtProt entry for DSCC1 Gene

Post-translational modifications for DSCC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DSCC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DSCC1 Gene

Domains & Families for DSCC1 Gene

Protein Domains for DSCC1 Gene

Suggested Antigen Peptide Sequences for DSCC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVC3

UniProtKB/Swiss-Prot:

DCC1_HUMAN :
  • Belongs to the DCC1 family.
Family:
  • Belongs to the DCC1 family.
genes like me logo Genes that share domains with DSCC1: view

No data available for Gene Families for DSCC1 Gene

Function for DSCC1 Gene

Molecular function for DSCC1 Gene

UniProtKB/Swiss-Prot Function:
Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

Gene Ontology (GO) - Molecular Function for DSCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003689 contributes_to DNA clamp loader activity IDA 12930902
GO:0005515 protein binding IPI 16682347
GO:0043142 contributes_to single-stranded DNA-dependent ATPase activity IDA 12930902
genes like me logo Genes that share ontologies with DSCC1: view
genes like me logo Genes that share phenotypes with DSCC1: view

Animal Models for DSCC1 Gene

MGI Knock Outs for DSCC1:

Animal Model Products

miRNA for DSCC1 Gene

miRTarBase miRNAs that target DSCC1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DSCC1 Gene

Localization for DSCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DSCC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DSCC1 Gene COMPARTMENTS Subcellular localization image for DSCC1 gene
Compartment Confidence
nucleus 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DSCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 16682347
GO:0000785 chromatin IDA 16682347
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 16682347
GO:0031390 Ctf18 RFC-like complex IDA 12930902
genes like me logo Genes that share ontologies with DSCC1: view

Pathways & Interactions for DSCC1 Gene

SuperPathways for DSCC1 Gene

SuperPathway Contained pathways
1 Gastric cancer network 2
genes like me logo Genes that share pathways with DSCC1: view

Pathways by source for DSCC1 Gene

1 BioSystems pathway for DSCC1 Gene

Gene Ontology (GO) - Biological Process for DSCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006275 regulation of DNA replication IMP 19907496
GO:0007049 cell cycle IEA --
GO:0034088 maintenance of mitotic sister chromatid cohesion IMP 16682347
GO:0034421 post-translational protein acetylation IMP 19907496
genes like me logo Genes that share ontologies with DSCC1: view

No data available for SIGNOR curated interactions for DSCC1 Gene

Transcripts for DSCC1 Gene

mRNA/cDNA for DSCC1 Gene

Unigene Clusters for DSCC1 Gene

Defective in sister chromatid cohesion 1 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DSCC1 Gene

No ASD Table

Relevant External Links for DSCC1 Gene

GeneLoc Exon Structure for
DSCC1
ECgene alternative splicing isoforms for
DSCC1

Expression for DSCC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DSCC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DSCC1 Gene

This gene is overexpressed in Ovary (43.7) and Fetal ovary (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DSCC1 Gene



Protein tissue co-expression partners for DSCC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DSCC1 Gene:

DSCC1

SOURCE GeneReport for Unigene cluster for DSCC1 Gene:

Hs.315167
genes like me logo Genes that share expression patterns with DSCC1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DSCC1 Gene

Orthologs for DSCC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DSCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DSCC1 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia DSCC1 34 35
  • 91.67 (n)
cow
(Bos Taurus)
Mammalia DSCC1 34 35
  • 88.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DSCC1 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dscc1 34
  • 85.88 (n)
mouse
(Mus musculus)
Mammalia Dscc1 34 16 35
  • 84.1 (n)
oppossum
(Monodelphis domestica)
Mammalia DSCC1 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves DSCC1 34 35
  • 75.17 (n)
lizard
(Anolis carolinensis)
Reptilia DSCC1 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dscc1 34
  • 68.38 (n)
Str.4502 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10004 34
zebrafish
(Danio rerio)
Actinopterygii dscc1 34 35
  • 67.53 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13927 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010703 34
  • 43.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11788 34 35
  • 41.94 (n)
worm
(Caenorhabditis elegans)
Secernentea K09H9.2 34 35
  • 41.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCC1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G44580 34
  • 45.27 (n)
rice
(Oryza sativa)
Liliopsida Os05g0119600 34
  • 43.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.825 35
  • 41 (a)
OneToOne
Species where no ortholog for DSCC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DSCC1 Gene

ENSEMBL:
Gene Tree for DSCC1 (if available)
TreeFam:
Gene Tree for DSCC1 (if available)

Paralogs for DSCC1 Gene

No data available for Paralogs for DSCC1 Gene

Variants for DSCC1 Gene

Sequence variations from dbSNP and Humsavar for DSCC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1048595 -- 119,854,373(+) TAATT(C/T)TCCTG intron-variant, nc-transcript-variant
rs1055130 -- 119,834,948(-) TTCTC(A/G)TTCTT intron-variant, reference, missense
rs1055131 -- 119,834,883(-) ACAAC(A/G)GTCTT intron-variant, utr-variant-3-prime
rs1055133 -- 119,834,838(-) GGATA(C/G)AAGAA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs10563348 -- 119,846,685(+) TCCCT(-/CCCT)AGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DSCC1 Gene

Variant ID Type Subtype PubMed ID
nsv612111 CNV gain 21841781

Variation tolerance for DSCC1 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DSCC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DSCC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSCC1 Gene

Disorders for DSCC1 Gene

Relevant External Links for DSCC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DSCC1

No disorders were found for DSCC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DSCC1 Gene

Publications for DSCC1 Gene

  1. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. (PMID: 12766176) Merkle C.J. … Chen J. (J. Biol. Chem. 2003) 2 3 4 64
  2. Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8. (PMID: 20826785) Murakami T. … Tsurimoto T. (J. Biol. Chem. 2010) 2 3 64
  3. Cohesin acetylation speeds the replication fork. (PMID: 19907496) Terret M.E. … Jallepalli P.V. (Nature 2009) 3 4 64
  4. Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. (PMID: 18499658) Farina A. … Hurwitz J. (J. Biol. Chem. 2008) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for DSCC1 Gene

Sources for DSCC1 Gene

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