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Aliases for DSCAM Gene

Aliases for DSCAM Gene

  • DS Cell Adhesion Molecule 2 3 5
  • Down Syndrome Cell Adhesion Molecule 2 3
  • CHD2 3 4
  • CHD2-42 3
  • CHD2-52 3

External Ids for DSCAM Gene

Previous GeneCards Identifiers for DSCAM Gene

  • GC21M037958
  • GC21M040305
  • GC21M040306
  • GC21M041382
  • GC21M026864

Summaries for DSCAM Gene

Entrez Gene Summary for DSCAM Gene

  • This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

GeneCards Summary for DSCAM Gene

DSCAM (DS Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with DSCAM include Down Syndrome-Related Congenital Heart Disease and Down Syndrome. Among its related pathways are PAK Pathway and Cell junction organization. An important paralog of this gene is DSCAML1.

UniProtKB/Swiss-Prot for DSCAM Gene

  • Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSCAM Gene

Genomics for DSCAM Gene

Regulatory Elements for DSCAM Gene

Enhancers for DSCAM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G040185 0.8 ENCODE 36.6 +660.3 660274 2.4 SOX13 BACH1 BMI1 ZNF697 RARA ARID3A GATA2 RELB CREM GATAD2A DSCAM MIR4760 GC21P040155
GH21G040844 0.9 FANTOM5 ENCODE 19.9 +1.7 1730 2.3 RFX1 ZNF316 ATF2 EP300 MAFK TRIM28 EZH2 DSCAM DSCAM-IT1
GH21G040176 0.6 ENCODE 26.2 +670.3 670291 0.2 ZNF263 RFX1 POLR2A REST RAD21 EP300 DSCAM GC21P040155 MIR4760
GH21G040603 0.3 FANTOM5 13.6 +243.6 243597 0.3 DSCAM DSCAM-IT1 ENSG00000207147
GH21G040592 0.5 FANTOM5 5.6 +254.0 254018 0.3 GATA3 FOXA1 DSCAM DSCAM-IT1 ENSG00000207147
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DSCAM on UCSC Golden Path with GeneCards custom track

Genomic Location for DSCAM Gene

Chromosome:
21
Start:
40,010,999 bp from pter
End:
40,847,139 bp from pter
Size:
836,141 bases
Orientation:
Minus strand

Genomic View for DSCAM Gene

Genes around DSCAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DSCAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DSCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSCAM Gene

Proteins for DSCAM Gene

  • Protein details for DSCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60469-DSCAM_HUMAN
    Recommended name:
    Down syndrome cell adhesion molecule
    Protein Accession:
    O60469
    Secondary Accessions:
    • O60468

    Protein attributes for DSCAM Gene

    Size:
    2012 amino acids
    Molecular mass:
    222260 Da
    Quaternary structure:
    • Homodimer; mediates homophilic interactions to promote cell adhesion (By similarity). Interacts with DCC; the interaction is abolished in response to NTN1 (By similarity). Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1 (PubMed:15169762). Interacts (via extracellular domain) with NTN1 (PubMed:19196994). Interacts (via cytoplasmic domain) with PAK1; the interaction is direct and enhanced in presence of RAC1. Interacts with RAC1; the interaction requires PAK1.

    Alternative splice isoforms for DSCAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DSCAM Gene

Post-translational modifications for DSCAM Gene

  • Phosphorylated at tyrosine residues. Phosphorylation is enhanced by netrin.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DSCAM Gene

No data available for DME Specific Peptides for DSCAM Gene

Domains & Families for DSCAM Gene

Suggested Antigen Peptide Sequences for DSCAM Gene

Graphical View of Domain Structure for InterPro Entry

O60469

UniProtKB/Swiss-Prot:

DSCAM_HUMAN :
  • Ig-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC (By similarity).
Domain:
  • Ig-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC (By similarity).
genes like me logo Genes that share domains with DSCAM: view

Function for DSCAM Gene

Molecular function for DSCAM Gene

GENATLAS Biochemistry:
neural cell adhesion molecule in the Down syndrome critical region,with several transcripts,largely expressed in the developing nervous system and adult brain,immunoglobulin superfamily,potentially involved in congenital heart disease
UniProtKB/Swiss-Prot Function:
Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).

Gene Ontology (GO) - Molecular Function for DSCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19196994
genes like me logo Genes that share ontologies with DSCAM: view
genes like me logo Genes that share phenotypes with DSCAM: view

Animal Models for DSCAM Gene

MGI Knock Outs for DSCAM:

Animal Model Products

  • Taconic Biosciences Mouse Models for DSCAM

CRISPR Products

miRNA for DSCAM Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DSCAM Gene

Localization for DSCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for DSCAM Gene

Isoform Short: Secreted.
Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell junction, synapse. Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. {ECO:0000250 UniProtKB:Q9ERC8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DSCAM gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 2
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DSCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane TAS,IEA 9426258
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DSCAM: view

Pathways & Interactions for DSCAM Gene

genes like me logo Genes that share pathways with DSCAM: view

Pathways by source for DSCAM Gene

1 BioSystems pathway for DSCAM Gene
2 Reactome pathways for DSCAM Gene
2 Qiagen pathways for DSCAM Gene

Gene Ontology (GO) - Biological Process for DSCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS,IEA 9426258
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS --
GO:0007162 negative regulation of cell adhesion IEA,ISS --
GO:0007399 nervous system development IEA,TAS 9426258
GO:0007416 synapse assembly ISS --
genes like me logo Genes that share ontologies with DSCAM: view

No data available for SIGNOR curated interactions for DSCAM Gene

Drugs & Compounds for DSCAM Gene

(2) Drugs for DSCAM Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 2050
Paclitaxel Approved, Vet_approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2864
genes like me logo Genes that share compounds with DSCAM: view

Transcripts for DSCAM Gene

Unigene Clusters for DSCAM Gene

Down syndrome cell adhesion molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DSCAM Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1:
SP2:

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
SP1:
SP2: -

Relevant External Links for DSCAM Gene

GeneLoc Exon Structure for
DSCAM
ECgene alternative splicing isoforms for
DSCAM

Expression for DSCAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DSCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DSCAM Gene

This gene is overexpressed in Brain - Amygdala (x5.1), Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Cortex (x4.7), Brain - Hypothalamus (x4.7), Pituitary (x4.5), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for DSCAM Gene

This gene is overexpressed in Heart (57.2) and Pancreatic juice (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DSCAM Gene



Protein tissue co-expression partners for DSCAM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DSCAM Gene:

DSCAM

SOURCE GeneReport for Unigene cluster for DSCAM Gene:

Hs.397800

mRNA Expression by UniProt/SwissProt for DSCAM Gene:

O60469-DSCAM_HUMAN
Tissue specificity: Primarily expressed in brain.

Evidence on tissue expression from TISSUES for DSCAM Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with DSCAM: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DSCAM Gene

Orthologs for DSCAM Gene

This gene was present in the common ancestor of animals.

Orthologs for DSCAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DSCAM 34 35
  • 99.5 (n)
oppossum
(Monodelphis domestica)
Mammalia DSCAM 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
OneToMany
-- 35
  • 93 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DSCAM 34 35
  • 92.85 (n)
cow
(Bos Taurus)
Mammalia DSCAM 34 35
  • 90.94 (n)
mouse
(Mus musculus)
Mammalia Dscam 34 16 35
  • 90.11 (n)
rat
(Rattus norvegicus)
Mammalia Dscam 34
  • 89.88 (n)
chicken
(Gallus gallus)
Aves DSCAM 34 35
  • 84.1 (n)
lizard
(Anolis carolinensis)
Reptilia DSCAM 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dscam 34
  • 80.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28566 34
zebrafish
(Danio rerio)
Actinopterygii dscamb 35
  • 79 (a)
ManyToMany
dscama 34 35
  • 73.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dscam4 34
  • 47.62 (n)
CG7060 36
  • 34 (a)
Dscam 36
  • 33 (a)
CG18630 36
  • 28 (a)
sdk 35
  • 17 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007092 34
  • 46.82 (n)
Species where no ortholog for DSCAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DSCAM Gene

ENSEMBL:
Gene Tree for DSCAM (if available)
TreeFam:
Gene Tree for DSCAM (if available)

Paralogs for DSCAM Gene

Paralogs for DSCAM Gene

(2) SIMAP similar genes for DSCAM Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DSCAM: view

Variants for DSCAM Gene

Sequence variations from dbSNP and Humsavar for DSCAM Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000006023 -- 40,558,431(+) CGACA(A/G)AGCAA intron-variant
rs1000006389 -- 40,786,801(+) TACTA(C/T)AGGCT intron-variant
rs1000006602 -- 40,493,325(+) AGAAA(C/T)ACTAA intron-variant
rs1000008192 -- 40,083,112(+) AGAAC(A/G)ACCAT intron-variant
rs1000008489 -- 40,307,152(+) ACCTA(A/C)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DSCAM Gene

Variant ID Type Subtype PubMed ID
dgv1272e212 CNV loss 25503493
dgv2390n106 CNV deletion 24896259
dgv2391n106 CNV deletion 24896259
dgv4434n100 CNV gain 25217958
dgv707e201 CNV deletion 23290073
dgv708e201 CNV deletion 23290073
dgv709e201 CNV deletion 23290073
dgv812e199 CNV deletion 23128226
esv1285936 CNV insertion 17803354
esv1290970 CNV deletion 17803354
esv1433285 OTHER inversion 17803354
esv1502218 CNV deletion 17803354
esv1557821 CNV insertion 17803354
esv1606716 CNV deletion 17803354
esv1662014 CNV deletion 17803354
esv1934003 CNV deletion 18987734
esv1942233 CNV deletion 18987734
esv2038671 CNV deletion 18987734
esv2363998 CNV deletion 18987734
esv2399855 CNV deletion 18987734
esv2519317 CNV insertion 19546169
esv25266 CNV loss 19812545
esv2555910 CNV deletion 19546169
esv2601819 CNV deletion 19546169
esv26953 CNV loss 19812545
esv2723446 CNV deletion 23290073
esv2723447 CNV deletion 23290073
esv2723452 CNV deletion 23290073
esv2723455 CNV deletion 23290073
esv2723457 CNV deletion 23290073
esv2723458 CNV deletion 23290073
esv2723459 CNV deletion 23290073
esv2723460 CNV deletion 23290073
esv2723462 CNV deletion 23290073
esv2723463 CNV deletion 23290073
esv2723464 CNV deletion 23290073
esv2723465 CNV deletion 23290073
esv2723466 CNV deletion 23290073
esv2723467 CNV deletion 23290073
esv2723468 CNV deletion 23290073
esv2723469 CNV deletion 23290073
esv2723470 CNV deletion 23290073
esv2723471 CNV deletion 23290073
esv2762112 CNV loss 21179565
esv2763256 CNV loss 21179565
esv29266 CNV gain+loss 19812545
esv3303657 CNV mobile element insertion 20981092
esv3306564 CNV mobile element insertion 20981092
esv3308121 CNV mobile element insertion 20981092
esv33309 CNV gain 17666407
esv3339698 CNV insertion 20981092
esv3345079 CNV insertion 20981092
esv3371453 CNV insertion 20981092
esv3377141 CNV insertion 20981092
esv3396367 CNV insertion 20981092
esv3404270 CNV insertion 20981092
esv3416759 OTHER inversion 20981092
esv3416951 CNV duplication 20981092
esv3452088 CNV insertion 20981092
esv3557727 CNV deletion 23714750
esv3557728 CNV deletion 23714750
esv3557736 CNV deletion 23714750
esv3568199 CNV loss 25503493
esv3647030 CNV loss 21293372
esv3647032 CNV loss 21293372
esv3647033 CNV loss 21293372
esv3647036 CNV loss 21293372
esv3647038 CNV gain 21293372
esv3647040 CNV loss 21293372
esv3647041 CNV loss 21293372
esv3647044 CNV loss 21293372
esv3647047 CNV loss 21293372
esv3893412 CNV loss 25118596
esv4710 CNV loss 18987735
esv4711 CNV loss 18987735
esv4745 CNV loss 18987735
esv998773 OTHER inversion 20482838
nsv1062498 CNV loss 25217958
nsv1065974 CNV gain 25217958
nsv1072178 CNV deletion 25765185
nsv1111228 CNV tandem duplication 24896259
nsv1116925 CNV deletion 24896259
nsv1116926 CNV deletion 24896259
nsv1121591 CNV deletion 24896259
nsv1123563 CNV deletion 24896259
nsv1127897 CNV deletion 24896259
nsv1129680 CNV tandem duplication 24896259
nsv1131638 CNV deletion 24896259
nsv1131640 CNV deletion 24896259
nsv1136639 CNV deletion 24896259
nsv1139026 CNV deletion 24896259
nsv1139027 CNV deletion 24896259
nsv1142329 CNV tandem duplication 24896259
nsv1142330 CNV tandem duplication 24896259
nsv1142331 CNV tandem duplication 24896259
nsv1147868 CNV deletion 26484159
nsv1160715 CNV duplication 26073780
nsv187086 CNV deletion 16902084
nsv187104 CNV deletion 16902084
nsv187130 CNV deletion 16902084
nsv187207 CNV deletion 16902084
nsv187221 CNV deletion 16902084
nsv3525 CNV insertion 18451855
nsv3526 CNV deletion 18451855
nsv3527 CNV insertion 18451855
nsv436673 OTHER inversion 17901297
nsv510506 OTHER sequence alteration 20534489
nsv513574 CNV insertion 21212237
nsv513717 OTHER inversion 21212237
nsv519745 CNV loss 19592680
nsv520586 CNV loss 19592680
nsv523501 CNV gain 19592680
nsv528658 CNV loss 19592680
nsv587488 CNV loss 21841781
nsv587489 CNV loss 21841781
nsv587490 CNV loss 21841781
nsv587491 CNV gain 21841781
nsv7346 OTHER inversion 18451855
nsv820759 CNV deletion 20802225
nsv834100 CNV gain 17160897
nsv834101 CNV gain 17160897
nsv953627 CNV deletion 24416366
nsv955458 CNV deletion 24416366
nsv956734 CNV deletion 24416366
nsv956756 CNV deletion 24416366
nsv956762 CNV deletion 24416366
nsv956779 CNV deletion 24416366

Variation tolerance for DSCAM Gene

Residual Variation Intolerance Score: 0.187% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DSCAM Gene

Human Gene Mutation Database (HGMD)
DSCAM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DSCAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSCAM Gene

Disorders for DSCAM Gene

MalaCards: The human disease database

(5) MalaCards diseases for DSCAM Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
down syndrome-related congenital heart disease
  • dschd
down syndrome
  • complete trisomy 21 syndrome
idiopathic scoliosis
  • scoliosis idiopathic
chromosomal disease
  • chromosomal disorders
heart disease
  • congestive heart failure
- elite association - COSMIC cancer census association via MalaCards
Search DSCAM in MalaCards View complete list of genes associated with diseases

Relevant External Links for DSCAM

Genetic Association Database (GAD)
DSCAM
Human Genome Epidemiology (HuGE) Navigator
DSCAM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DSCAM
genes like me logo Genes that share disorders with DSCAM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DSCAM Gene

Publications for DSCAM Gene

  1. Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion. (PMID: 10925149) Agarwala K.L. … Yamakawa K. (Brain Res. Mol. Brain Res. 2000) 3 4 22 64
  2. DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. (PMID: 9426258) Yamakawa K. … Korenberg J.R. (Hum. Mol. Genet. 1998) 2 3 4 64
  3. Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel. (PMID: 21079520) Sato Y. … Tamura T. (J Thorac Oncol 2011) 3 46 64
  4. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V. … Ndung'u T. (Clin. Infect. Dis. 2011) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for DSCAM Gene

Sources for DSCAM Gene

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