DSC3 Gene

Aliases
for DSC3 gene

Previous GC identifers: GC18M028389 GC18M026823 GC18M026825 GC18M025425

Summaries
for DSC3 gene

Genomic Views
for DSC3 gene

RefSeq DNA sequence:

NC_000018.9  NC_018929.1  NT_010966.14  

SwitchGear Promoter luciferase reporter plasmid: DSC3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DSC3

DSC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M028593:  view genomic region     (about GC identifiers)

Proteins
for DSC3 gene

Explore the universe of human proteins at neXtProt for DSC3: NX_Q14574

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for DSC3 (Desmocollin-3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for DSC3
	GenScript Custom Purified and Recombinant Proteins Services for DSC3
	Novus Biologicals DSC3 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DSC3

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for DSC3 (Desmocollin-3)
	OriGene Antibodies: DSC3 OriGene Custom Antibody Services for DSC3
	GenScript Custom Superior Antibodies Services for DSC3
	Novus Biologicals DSC3 Antibodies
	Abcam antibodies for DSC3
	Uscn Antibodies for DSC3
	Search ThermoFisher Antibodies for DSC3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DSC3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DSC3

Protein Domains /
Families
for DSC3 gene

ProtoNet protein and cluster: Q14574

Function
for DSC3 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): DSC3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DSC3
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate DSC3 (see all 28):
		hsa-miR-548j hsa-miR-217 hsa-miR-3607-3p hsa-miR-4307 hsa-miR-548i hsa-miR-138-2* hsa-miR-340 hsa-miR-205*
		SwitchGear 3'UTR luciferase reporter plasmid: DSC3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DSC3 (see all 7) OriGene shRNA RFP: DSC3 OriGene siRNA: DSC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DSC3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for DSC3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DSC3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DSC3 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DSC3 (NM_001941)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DSC3
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DSC3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DSC3
		Search LifeMap BioReagents cell lines for DSC3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSC3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Dsc3)

Pathways & Interactions
for DSC3 gene

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for DSC3 gene

Transcripts
for DSC3 gene

Expression
for DSC3 gene

DSC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DSC3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DSC3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DSC3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DSC3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DSC3

Orthologs
for DSC3 gene

Paralogs
for DSC3 gene

Paralogs for DSC3 gene

CDH4²  CDH18²  DSG4²  CDH3²  CDH10²  CDH11²  CDH1²  CDH6²  

DSC2²  CDH8²  CDH20²  CDH22²  DSC1²  CDH19²  DSG1²  CDH7²  

DSG2²  CDH9²  CDH12²  CDH26²  CDH2²  CDH24²  CDH15²  CDH5²  

DSG3²  

10 SIMAP similar genes for DSC3 using alignment to 3 protein entries:     DSC3_HUMAN (see all proteins):

DKFZp686P18250    DSC2    DKFZp686I11137    DSC1    CDH13    CDH2

CDH3    CDH15    CDH4    DSG4

DSC3 for paralogs           About GeneDecksing

Genomic Variants
for DSC3 gene

10/1190 NCBI SNPs in DSC3 are shown (see all 1190)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1477548501,2	C,	other	57368975(+)	TCACCA/GAGACG	4	L	syn1		0	--	--	--	--
rs124579201,2	C,H	--	25426941(+)	AAATAG/TTACTT	2	--	ut31		1		NA	2
rs785095731,2	C,F,	--	25427432(+)	GGGAGG/ATAGCA	2	--	ut31		4		CSA WA NA	242
rs1119443051,2		--	25427824(+)	AACCCC/TGTCTC	2	--	ut31		1		CSA	2
rs713613091,2	C,	--	25428246(+)	GTCAGC/TTCTGT	2	--	ut31		3		NA	124
rs763436071,2	C,F,	--	25428389(+)	GCAGAC/TGATGT	2	--	ut31		1		WA	118
rs789851171,2	C,F,	--	25428494(+)	GGGCTG/ACTTTC	2	--	ut31		1		NA	120
rs1137696681,2	C,	--	25428501(+)	TTTCTC/TCCAAA	2	--	ut31		2		NA	122
rs751572911,2	C,F,	--	25428696(+)	AAAGCC/TGAAAG	2	--	ut31		1		WA	118
rs788095191,2		--	25428745(+)	CAATGC/ACACTC	2	--	ut31		1		EA	120

HapMap Linkage Disequilibrium report for DSC3 (28569974 - 28622781 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for DSC3: --
Human Gene Mutation Database (HGMD): DSC3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DSC3

DNA2.0 Custom Variant and Variant Library Synthesis for DSC3

Disorders / Diseases
for DSC3 gene

19 diseases for DSC3

10 Novoseek disease relationships for DSC3 gene    About this table

Publications
for DSC3 gene

PubMed articles for DSC3 gene, integrated from 9 sources (see all 76): (articles sorted by number of sources associating them with DSC3)

Utopia: connect your pdf to the dynamic world of online information

1. The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms. (PubMed id 7665906)^{1, 2, 9} King I.A.... Buxton R.S. (1995)
2. Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3. (PubMed id 11027496)^{1, 2, 9} Whittock N.V.... McGrath J.A. (2000)
3. Assignment of the human genes for desmocollin 3 (DSC3) and desmocollin 4 (DSC4) to chromosome 18q12. (PubMed id 7774948)^{1, 3, 9} Amagai M.... Shimizu N. (1995)
4. A homozygous nonsense mutation in the human desmocollin-3 (DSC3) gene underlies hereditary hypotrichosis and recurrent skin vesicles. (PubMed id 19765682)^{1, 2, 9} Ayub M....Ahmad W. (2009)
5. cDNA cloning and expression of a novel human desmocollin. (PubMed id 7929347)^{1, 2} Kawamura K.... Tsurufuji S. (1994)
6. Nomenclature of the desmosomal cadherins. (PubMed id 8486729)^{1, 3} Buxton R.S....Stanley J.R. (1993)
7. Epigenetic silencing of DSC3 is a common event in human breast cancer. (PubMed id 16168112)^{1, 9} Oshiro M.M....Futscher B.W. (2005)
8. Desmocollin switching in colorectal cancer. (PubMed id 17088906)^{1, 9} Khan K....Chidgey M. (2006)
9. Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells. (PubMed id 8884173)^{1, 9} Nuber U.A....Franke W.W. (1996)
10. Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP). (PubMed id 1889810)^{1, 9} Arnemann J....Buxton R.S. (1991)

External Searches for DSC3 gene

Genome Databases showing DSC3 gene

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Specialized Databases showing DSC3 gene

Products
for DSC3 gene