Aliases for DSC1 Gene
External Ids for DSC1 Gene
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for DSC1 Gene
DSC1 (Desmocollin 1) is a Protein Coding gene. Diseases associated with DSC1 include atrophic lichen planus and subcorneal pustular dermatosis. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH13.
UniProtKB/Swiss-Prot for DSC1 Gene
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues