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Aliases for DRP2 Gene

Aliases for DRP2 Gene

  • Dystrophin Related Protein 2 2 3
  • DRP-2 3 4
  • Dystrophin-Related Protein 2 3

External Ids for DRP2 Gene

Previous GeneCards Identifiers for DRP2 Gene

  • GC0XP095756
  • GC0XP097436
  • GC0XP098510
  • GC0XP099246
  • GC0XP100281
  • GC0XP100361
  • GC0XP100474
  • GC0XP090278

Summaries for DRP2 Gene

Entrez Gene Summary for DRP2 Gene

  • Members of the dystrophin family of proteins perform a critical role in the maintenance of membrane-associated complexes at points of intercellular contact in vertebrate cells. The protein encoded by this gene is predicted to resemble certain short C-terminal isoforms of dystrophin and dystrophin-related protein 1 (DRP1 or utrophin). DRP2 is expressed principally in the brain and spinal cord. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for DRP2 Gene

DRP2 (Dystrophin Related Protein 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is UTRN.

UniProtKB/Swiss-Prot for DRP2 Gene

  • Possibly involved in membrane-cytoskeleton interactions of the central nervous system.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRP2 Gene

Genomics for DRP2 Gene

Regulatory Elements for DRP2 Gene

Genomic Location for DRP2 Gene

Start:
101,219,769 bp from pter
End:
101,264,503 bp from pter
Size:
44,735 bases
Orientation:
Plus strand

Genomic View for DRP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRP2 Gene

Proteins for DRP2 Gene

  • Protein details for DRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13474-DRP2_HUMAN
    Recommended name:
    Dystrophin-related protein 2
    Protein Accession:
    Q13474
    Secondary Accessions:
    • A6ZKI5
    • A8K1B0
    • B1B1F3
    • B4DIZ0

    Protein attributes for DRP2 Gene

    Size:
    957 amino acids
    Molecular mass:
    107962 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50538.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI11696.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF82514.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DRP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRP2 Gene

Proteomics data for DRP2 Gene at MOPED

Post-translational modifications for DRP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DRP2 Gene

No data available for DME Specific Peptides for DRP2 Gene

Domains for DRP2 Gene

Suggested Antigen Peptide Sequences for DRP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13474

UniProtKB/Swiss-Prot:

DRP2_HUMAN :
  • Q13474
Domain:
  • Contains 1 WW domain.
Similarity:
  • Contains 2 spectrin repeats.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with DRP2: view

No data available for Gene Families for DRP2 Gene

Function for DRP2 Gene

Molecular function for DRP2 Gene

GENATLAS Biochemistry: dystrophin related protein 2,expressed in brain and spinal cord,homolog of Apo-dystrophin 2 (Dp116)
UniProtKB/Swiss-Prot Function: Possibly involved in membrane-cytoskeleton interactions of the central nervous system.

Gene Ontology (GO) - Molecular Function for DRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with DRP2: view

Phenotypes for DRP2 Gene

genes like me logo Genes that share phenotypes with DRP2: view

Animal Models for DRP2 Gene

MGI Knock Outs for DRP2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DRP2 Gene

Localization for DRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRP2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRP2 Gene COMPARTMENTS Subcellular localization image for DRP2 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
nucleus 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with DRP2: view

Pathways for DRP2 Gene

SuperPathways for DRP2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development IEA --
genes like me logo Genes that share ontologies with DRP2: view

No data available for Pathways by source for DRP2 Gene

Transcripts for DRP2 Gene

Unigene Clusters for DRP2 Gene

Dystrophin related protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DRP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRP2 Gene

No ASD Table

Relevant External Links for DRP2 Gene

GeneLoc Exon Structure for
DRP2
ECgene alternative splicing isoforms for
DRP2

Expression for DRP2 Gene

mRNA expression in normal human tissues for DRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRP2 Gene

This gene is overexpressed in Nerve - Tibial (26.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DRP2 Gene

SOURCE GeneReport for Unigene cluster for DRP2 Gene Hs.159291

mRNA Expression by UniProt/SwissProt for DRP2 Gene

Q13474-DRP2_HUMAN
Tissue specificity: Brain and spinal cord; very low levels in eye, ovary, epididymis and testis; not in cardiac and skeletal muscle.
genes like me logo Genes that share expressions with DRP2: view

In Situ Assay Products

Orthologs for DRP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRP2 35
  • 99.72 (n)
  • 99.9 (a)
DRP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DRP2 35
  • 91.85 (n)
  • 94.36 (a)
DRP2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRP2 35
  • 92.72 (n)
  • 95.72 (a)
DRP2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drp2 35
  • 90.67 (n)
  • 95.09 (a)
Drp2 16
Drp2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRP2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRP2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drp2 35
  • 90.42 (n)
  • 95.5 (a)
chicken
(Gallus gallus)
Aves DRP2 35
  • 79.58 (n)
  • 87.35 (a)
DRP2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRP2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drp2 35
  • 67.83 (n)
  • 72.24 (a)
Str.4975 35
zebrafish
(Danio rerio)
Actinopterygii drp2 35
  • 68.99 (n)
  • 72.27 (a)
drp2 36
  • 72 (a)
OneToOne
Species with no ortholog for DRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DRP2 Gene

ENSEMBL:
Gene Tree for DRP2 (if available)
TreeFam:
Gene Tree for DRP2 (if available)

Paralogs for DRP2 Gene

Paralogs for DRP2 Gene

Selected SIMAP similar genes for DRP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DRP2: view

Variants for DRP2 Gene

Sequence variations from dbSNP and Humsavar for DRP2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1475971 -- 101,263,459(-) GTTCT(C/G)TGATA utr-variant-3-prime
rs1475972 -- 101,263,176(-) CACAC(A/G)TACTG utr-variant-3-prime
rs2187702 -- 101,258,977(-) ACACC(C/T)TTAGA intron-variant
rs2238990 -- 101,249,613(-) CTGCC(A/G)TTTCC intron-variant
rs2238991 -- 101,249,561(-) AGGCT(C/G)GACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRP2 Gene

Variant ID Type Subtype PubMed ID
nsv524411 CNV Loss 19592680

Relevant External Links for DRP2 Gene

HapMap Linkage Disequilibrium report
DRP2
Human Gene Mutation Database (HGMD)
DRP2
Locus Specific Mutation Databases (LSDB)
DRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRP2 Gene

Disorders for DRP2 Gene

Relevant External Links for DRP2

Genetic Association Database (GAD)
DRP2
Human Genome Epidemiology (HuGE) Navigator
DRP2
genes like me logo Genes that share disorders with DRP2: view

No data available for UniProtKB/Swiss-Prot for DRP2 Gene

Publications for DRP2 Gene

  1. Characterization of DRP2, a novel human dystrophin homologue. (PMID: 8640231) Roberts R.G. … Bobrow M. (Nat. Genet. 1996) 2 3 4 23
  2. No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. (PMID: 12951196) Nakata K. … Kuroda S. (Neurosci. Lett. 2003) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Contribution of the different modules in the utrophin carboxy- terminal region to the formation and regulation of the DAP complex. (PMID: 10767429) Tommasi di Vignano A. … Dente L. (FEBS Lett. 2000) 3 23
  5. Polymorphisms and haplotypes in the C-reactive protein gene and risk of dementia. (PMID: 16854501) van Oijen M. … Breteler M.M. (Neurobiol. Aging 2007) 3 48

Products for DRP2 Gene

Sources for DRP2 Gene

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