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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DROSHA Gene

protein-coding   GIFtS: 57
GCID: GC05M031401

Drosha, Ribonuclease Type III

(Previous names: ribonuclease type III, nuclear)
(Previous symbol: RNASEN)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Drosha, Ribonuclease Type III1 2     drosha1
RNASEN1 2 3 5     Ribonuclease Type III1
RN32 3 5     ETOHI22
Ribonuclease Type III, Nuclear1 2     HSA2429762
Protein Drosha2 3     Drosha, Double-Stranded RNA-Specific Endoribonuclease2
RNASE3L2 3     Nuclear RNase III Drosha2
p2412 3     Putative Protein P241 Which Interacts With Transcription Factor Sp12
RNase III2 3     Putative Ribonuclease III2
EC 3.1.26.33 8     Ribonuclease 32
RANSE3L2 5     Ribonuclease III, Nuclear2
Double-Stranded RNA-Specific Endoribonuclease1     Ribonuclease III3

External Ids:    HGNC: 179041   Entrez Gene: 291022   Ensembl: ENSG000001133607   OMIM: 6088285   UniProtKB: Q9NRR43   

Export aliases for DROSHA gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DROSHA Gene:
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in
diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 (PubMed
12191433)). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA)
processing in the nucleus (Lee et al., 2003 (PubMed 14508493)).(supplied by OMIM, Mar 2008)

GeneCards Summary for DROSHA Gene: 
DROSHA (drosha, ribonuclease type III) is a protein-coding gene. Diseases associated with DROSHA include digeorge syndrome, and skin cancer, and among its related super-pathways are MicroRNA (miRNA) Biogenesis and Generic Transcription Pathway. GO annotations related to this gene include double-stranded RNA binding and ribonuclease III activity.

UniProtKB/Swiss-Prot: RNC_HUMAN, Q9NRR4
Function: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step
of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA
transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor
complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the
dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to
generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave
single-strand RNA. Involved in the formation of GW bodies

Gene Wiki entry for DROSHA (RNASEN) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DROSHA
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDROSHA promoter sequence
   Search SABiosciences Chromatin IP Primers for DROSHA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DROSHA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.3   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5q11.2

DROSHA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DROSHA gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M031401:  view genomic region     (about GC identifiers)

Start:
31,400,601 bp from pter      End:
31,532,303 bp from pter
Size:
131,703 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNC_HUMAN, Q9NRR4 (See protein sequence)
Recommended Name: Ribonuclease 3  
Size: 1374 amino acids; 159316 Da
Cofactor: Magnesium or manganese (By similarity)
Subunit: Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of
DROSHA and DGCR8. The microprocessor complex may contain multiple subunit of DGCR8 and DROSHA. Interacts with
DGCR8, SP1 and SNIP1. Interacts with SRRT/ARS2
Subcellular location: Nucleus. Nucleus, nucleolus. Note=A fraction is translocated to the nucleolus during the S
phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies
Sequence caution: Sequence=AAD29637.1; Type=Frameshift; Positions=775; Sequence=BAA91511.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for DROSHA:
2KHX (3D)    
Secondary accessions: E7EMP9 Q7Z5V2 Q86YH0 Q9NW73 Q9Y2V9 Q9Y4Y0
Alternative splicing: 4 isoforms:  Q9NRR4-1   Q9NRR4-2   Q9NRR4-3   Q9NRR4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DROSHA: NX_Q9NRR4

Explore proteomics data for DROSHA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRR4

  • 4 DME Specific Peptides for DROSHA (Q9NRR4)
     CVKGLEL  EFLGDAV  RLEFLGDA  NERLEFLGD 

    DROSHA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DROSHA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001093882.1  NP_037367.3  

    ENSEMBL proteins: 
     ENSP00000425979   ENSP00000424161   ENSP00000422745   ENSP00000428782   ENSP00000430921  
     ENSP00000339845   ENSP00000409335  
    Reactome Protein details: Q9NRR4
    Human Recombinant Protein Products for DROSHA: 
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    OriGene Protein Over-expression Lysate for DROSHA
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DROSHA
    GenScript Custom Purified and Recombinant Proteins Services for DROSHA
    Novus Biologicals DROSHA Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IEA--

    DROSHA for ontologies           About GeneDecksing



    DROSHA Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DROSHA 

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    GenScript Custom Assay Services for DROSHA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001159 Ds-RNA-bd
     IPR011907 RNase_III
     IPR000999 RNase_III_dom
     IPR014720 dsRNA-bd-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRR4

    ProtoNet protein and cluster: Q9NRR4

    2 Blocks protein domains:
    IPB000999 Ribonuclease III family
    IPB001159 Double-stranded RNA binding (DsRBD) domain


    UniProtKB/Swiss-Prot: RNC_HUMAN, Q9NRR4
    Domain: The 2 RNase III domains form an intramolecular dimer where the domain 1 cuts the 3'strand while the domain
    2 cleaves the 5'strand of pri-miRNAs, independently of each other
    Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain
    Similarity: Contains 2 RNase III domains


    DROSHA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNC_HUMAN, Q9NRR4
    Function: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step
    of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA
    transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor
    complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the
    dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to
    generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave
    single-strand RNA. Involved in the formation of GW bodies
    Catalytic activity: Endonucleolytic cleavage to 5'-phosphomonoester

         Enzyme Number (IUBMB): EC 3.1.26.31 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0003725double-stranded RNA binding ----
    GO:0004521endoribonuclease activity ----
    GO:0004525ribonuclease III activity IEA--
    GO:0005515protein binding IPI15574589
         
    DROSHA for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Drosha):
     adipose tissue  cardiovascular system  cellular  digestive/alimentary  growth/size 
     hematopoietic system  immune system  integument  liver/biliary system  mortality/aging 
     muscle  respiratory system 

    DROSHA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Droshatm1.1Litt for DROSHA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DROSHA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DROSHA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DROSHA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DROSHA 

    miRNA
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    hsa-miR-4288 hsa-miR-128 hsa-miR-632 hsa-miR-1205 hsa-miR-15b* hsa-miR-205* hsa-miR-1231 hsa-miR-4289
    SwitchGear 3'UTR luciferase reporter plasmidDROSHA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DROSHA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DROSHA About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulatory RNA pathways
    Regulatory RNA pathways0.88
    MicroRNA (miRNA) Biogenesis0.88
    2Generic Transcription Pathway
    Gene Expression0.47
    3Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes
    4Proteoglycans in cancer
    Proteoglycans in cancer
    5Direct p53 effectors
    Direct p53 effectors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DROSHA
        Translational Control

    1 BioSystems Pathway for DROSHA
        Direct p53 effectors

    3        Reactome Pathways for DROSHA
        MicroRNA (miRNA) Biogenesis
    Regulatory RNA pathways
    Gene Expression


    2         Kegg Pathways  (Kegg details for DROSHA):
        Ribosome biogenesis in eukaryotes
    Proteoglycans in cancer


    DROSHA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DROSHA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/28 Interacting proteins for DROSHA (Q9NRR41, 2, 3 ENSP000003398454) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DGCR8Q8WYQ51, 2, 3, ENSP000002632094EBI-528367,EBI-528411 MINT-8329598 I2D: score=4 STRING: ENSP00000263209
    ZNF512BQ96KM62, 3, ENSP000002171304MINT-60789 I2D: score=2 STRING: ENSP00000217130
    SNIP1Q8TAD83, ENSP000002962154I2D: score=1 STRING: ENSP00000296215
    SP1P080473, ENSP000003293574I2D: score=2 STRING: ENSP00000329357
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing ----
    GO:0010467gene expression TAS--
    GO:0010468regulation of gene expression ----
    GO:0010586miRNA metabolic process IEA--
    GO:0016075rRNA catabolic process IEA--

    DROSHA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DROSHA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DROSHA (RNC)

    3 Novoseek inferred chemical compound relationships for DROSHA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polynucleotide 61.3 7 11726520 (4), 1628624 (2), 8901510 (1)
    leucine 0 1 17017124 (1)
    adenylate 0 1 15100988 (1)

    Search CenterWatch for drugs/clinical trials and news about DROSHA / RNC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DROSHA gene (2 alternative transcripts): 
    NM_001100412.1  NM_013235.4  

    Unigene Cluster for DROSHA:

    Drosha, ribonuclease type III
    Hs.97997  [show with all ESTs]
    Unigene Representative Sequence: NM_013235
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000511367(uc003jhh.2 uc003jhg.2) ENST00000513349(uc003jhi.2 uc010iui.1)
    ENST00000514927 ENST00000511778 ENST00000512166 ENST00000509067 ENST00000504133
    ENST00000510178 ENST00000505601 ENST00000507174 ENST00000509608 ENST00000512124
    ENST00000511803 ENST00000510375 ENST00000512885 ENST00000512076 ENST00000512302
    ENST00000507438
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate DROSHA (see all 18):
    hsa-miR-4288 hsa-miR-128 hsa-miR-632 hsa-miR-1205 hsa-miR-15b* hsa-miR-205* hsa-miR-1231 hsa-miR-4289
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF116910.1 AF189011.1 AJ242976.1 AK001121.1 AK026563.1 AK308093.1 BC024261.1 BC041162.1 
    BC054003.1 BX647724.1 

    22 DOTS entries:

    DT.441061  DT.75155929  DT.101983341  DT.95135231  DT.95135237  DT.91902617  DT.75145749  DT.91931526 
    DT.120873851  DT.91755996  DT.95331086  DT.99956997  DT.120873889  DT.120873903  DT.40211533  DT.431844 
    DT.86852147  DT.91999881  DT.101983342  DT.120873879  DT.40119217  DT.91905742 

    24/180 AceView cDNA sequences (see all 180):

    AW874309 BC041162 BP363363 AW438881 AU142521 AF116910 AA460045 AA917625 
    AU120566 CR613595 BP349758 BX090869 BU155281 BC024261 AI864626 BC054003 
    BX647724 AV709821 AA749416 AI972095 CR607257 BM698705 BE385337 BE792065 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for DROSHA (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
    SP1:                    -                                               -                                         -                                         -   
    SP2:                    -     -                                                                                   -                                         -   
    SP3:                    -     -                                         -                                         -                                         -   
    SP4:                                                              -     -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a ·
    SP1:  -                 -                             -                                   -                                         -                 -     -   
    SP2:  -                 -                             -                                   -                                         -                 -     -   
    SP3:  -                 -                             -                                   -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                      -                                                                     

    ExUns: 37b ^ 38 ^ 39a · 39b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for DROSHA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DROSHA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGTGTGGA
    DROSHA Expression
    About this image


    See DROSHA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DROSHA

    SOURCE GeneReport for Unigene cluster: Hs.97997

    UniProtKB/Swiss-Prot: RNC_HUMAN, Q9NRR4
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DROSHA gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Drosha1 , 5 drosha, ribonuclease type III1, 5 87.8(n)1
    95.77(a)1
      15 (5.99 cM)5
    140001  NM_001130149.11  NP_001123621.11 
     128248635 
    chicken
    (Gallus gallus)
    Aves DROSHA1 drosha, ribonuclease type III 79.87(n)
    88.48(a)
      420911  NM_001006379.1  NP_001006379.1 
    lizard
    (Anolis carolinensis)
    Reptilia DROSHA6
    Uncharacterized protein
    83(a)
    1 ↔ 1
    GL343408.1(243814-381357)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.155432 Xenopus laevis transcribed sequence with moderate similarity more 82.56(n)    BJ094119.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.115102 Transcribed sequence with weak similarity to protein more 76.41(n)    BG303805.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta drosha1 CG8730-PA 53.63(n)
    51.64(a)
      35747  NM_058088.3  NP_477436.1 
    worm
    (Caenorhabditis elegans)
    Secernentea drsh-11 Protein DRSH-1 45.52(n)
    32.86(a)
      172830  NM_001128988.1  NP_001122460.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RNT1(YMR239C)4 RNAase III; involved in rDNA transcription and rRNA more   --   13(749677-748262) 855280  NP_013966.1 


    ENSEMBL Gene Tree for DROSHA (if available)
    TreeFam Gene Tree for DROSHA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2780 SNPs in DROSHA are shown (see all 2780)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs723896281,2
    C--31371885(+) ATGCA-/AA/   
       AAAAA
    AAAAA
    2 -- int10--------
    rs1420151281,2
    C--31400103(+) CGCCCA/GCCACC 2 -- ds50010--------
    rs1832662981,2
    --31400112(+) CCATGC/TCTGGG 2 -- ds50010--------
    rs1119452731,2
    C--31400116(+) GCCTGG/TGTAAT 2 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1881414411,2
    C--31400301(+) TTATAG/TAAGAA 2 -- ds50010--------
    rs1167012181,2
    C,F--31400374(+) TTAGGG/AAGAAC 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1126235151,2
    C--31400451(+) GGTCTG/ATTGTG 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1930782801,2
    --31400817(+) TATTGA/GGAGGT 2 -- ut310--------
    rs1846406021,2
    --31400998(+) GCCAAA/TTAATT 2 -- ut310--------
    rs6423211,2
    C,F,O,A,H--31401003(+) TTAATC/TGTTAA 2 -- ut3137Minor allele frequency- T:0.40EA NA MN NS WA CSA 5602

    HapMap Linkage Disequilibrium report for DROSHA (31400601 - 31532303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DROSHA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4776CNV Insertion18451855
    esv34132CNV Loss18971310
    dgv340n21CNV Loss19592680
    nsv819630CNV Gain19587683
    nsv881382CNV Gain21882294
    nsv830249CNV Gain17160897
    dgv1788e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): DROSHA
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608828    OMIM disorders: --

    20/22 diseases for DROSHA (see all 22):    About MalaCards
    digeorge syndrome    skin cancer    esophageal cancer    esophagitis
    myelodysplastic syndromes    esophageal squamous cell carcinoma    nasopharyngitis    renal cell carcinoma
    cervical cancer    pneumonia    hepatitis b    cervicitis
    squamous cell carcinoma    tuberculosis    neuroblastoma    colon cancer
    schizophrenia    ovarian cancer    lung cancer    hepatitis


    DROSHA for disorders           About GeneDecksing


    Export disorders for DROSHA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DROSHA gene, integrated from 9 sources (see all 170):
    (articles sorted by number of sources associating them with DROSHA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human RNase III is a 160-kDa protein involved in preribosomal RNA processing. (PubMed id 10948199)1, 2, 3, 9 Wu H.... Crooke S.T. (2000)
    2. A novel type of RNase III family proteins in eukaryotes. (PubMed id 10713462)1, 3, 9 Filippov V....Gill S.S. (2000)
    3. The Drosha-DGCR8 complex in primary microRNA processing. (PubMed id 15574589)1, 2, 9 Han J.... Kim V.N. (2004)
    4. The nuclear RNase III Drosha initiates microRNA processing. (PubMed id 14508493)1, 2, 9 Lee Y.... Kim V.N. (2003)
    5. The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis. (PubMed id 15589161)1, 2, 9 Landthaler M.... Tuschl T. (2004)
    6. The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis. (PubMed id 18632581)1, 2 Yu B.... Chen X. (2008)
    7. Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. (PubMed id 15565168)1, 2 Zeng Y....Cullen B.R. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The Microprocessor complex mediates the genesis of microRNAs. (PubMed id 15531877)1, 2 Gregory R.I....Shiekhattar R. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29102 HGNC: 17904 AceView: RNASE3L Ensembl:ENSG00000113360 euGenes: HUgn29102
    ECgene: DROSHA Kegg: 29102 H-InvDB: DROSHA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DROSHA Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt087.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DROSHA gene:
    Search GeneIP for patents involving DROSHA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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