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Aliases for DRGX Gene

Aliases for DRGX Gene

  • Dorsal Root Ganglia Homeobox 2 3 5
  • Paired-Like Homeodomain Trancription Factor DRG11 2 3
  • Paired Related Homeobox-Like 1 2 3
  • PRRXL1 3 4
  • Paired-Related Homeobox Protein-Like 1 4
  • Dorsal Root Ganglia Homeobox Protein 3
  • DRG11 3

External Ids for DRGX Gene

Previous HGNC Symbols for DRGX Gene

  • PRRXL1

Previous GeneCards Identifiers for DRGX Gene

  • GC10M050243
  • GC10M050573
  • GC10M044838

Summaries for DRGX Gene

GeneCards Summary for DRGX Gene

DRGX (Dorsal Root Ganglia Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ARX.

UniProtKB/Swiss-Prot for DRGX Gene

  • Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRGX Gene

Genomics for DRGX Gene

Regulatory Elements for DRGX Gene

Enhancers for DRGX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F049309 1.3 FANTOM5 Ensembl ENCODE 23 +85.2 85208 2.7 BCOR NFIA MTA2 MAFG ZMYM3 EBF1 MEF2D ZNF121 ZNF316 IKZF1 DRGX C10orf128 C10orf71-AS1 GC10M049333
GH10F049395 2.2 VISTA FANTOM5 8.6 -0.5 -468 1.5 HDAC1 ATF1 PKNOX1 SIN3A FEZF1 ZNF766 GATA2 RCOR1 CEBPB OVOL3 DRGX GC10P049396 LOC105378300
GH10F049205 1.6 VISTA 10.7 +190.2 190185 0.9 ZNF121 GLIS1 HMBOX1 MLLT1 KDM1A DRGX C10orf71-AS1 C10orf71 C10orf128 GC10P049274
GH10F049296 1.4 FANTOM5 ENCODE 11.8 +97.0 96984 6.0 HDGF PKNOX1 ARNT CREB3L1 FEZF1 CBX5 ZNF143 JUNB REST TBX21 DRGX C10orf71 C10orf71-AS1 GC10M049333
GH10F049335 0.7 ENCODE 21.6 +60.4 60428 0.9 HDGF HDAC1 BCOR ESRRA CBX3 ZMYM3 ZBTB40 CHAMP1 ZNF664 NR2F2 DRGX C10orf71-AS1 C10orf71 PGBD3 GC10M049333
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DRGX on UCSC Golden Path with GeneCards custom track

Genomic Location for DRGX Gene

Chromosome:
10
Start:
49,364,066 bp from pter
End:
49,396,016 bp from pter
Size:
31,951 bases
Orientation:
Minus strand

Genomic View for DRGX Gene

Genes around DRGX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRGX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRGX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRGX Gene

Proteins for DRGX Gene

  • Protein details for DRGX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNA5-DRGX_HUMAN
    Recommended name:
    Dorsal root ganglia homeobox protein
    Protein Accession:
    A6NNA5

    Protein attributes for DRGX Gene

    Size:
    263 amino acids
    Molecular mass:
    28672 Da
    Quaternary structure:
    • Interacts with RGMB.

neXtProt entry for DRGX Gene

Post-translational modifications for DRGX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DRGX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRGX Gene

Domains & Families for DRGX Gene

Gene Families for DRGX Gene

Protein Domains for DRGX Gene

Suggested Antigen Peptide Sequences for DRGX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NNA5

UniProtKB/Swiss-Prot:

DRGX_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with DRGX: view

Function for DRGX Gene

Molecular function for DRGX Gene

UniProtKB/Swiss-Prot Function:
Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.

Gene Ontology (GO) - Molecular Function for DRGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DRGX: view
genes like me logo Genes that share phenotypes with DRGX: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DRGX Gene

Localization for DRGX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRGX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRGX gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for DRGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DRGX: view

Pathways & Interactions for DRGX Gene

No Data Available

Interacting Proteins for DRGX Gene

Gene Ontology (GO) - Biological Process for DRGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with DRGX: view

No data available for Pathways by source and SIGNOR curated interactions for DRGX Gene

Transcripts for DRGX Gene

mRNA/cDNA for DRGX Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DRGX Gene

Dorsal root ganglia homeobox:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRGX Gene

No ASD Table

Relevant External Links for DRGX Gene

GeneLoc Exon Structure for
DRGX
ECgene alternative splicing isoforms for
DRGX

Expression for DRGX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DRGX Gene

mRNA differential expression in normal tissues according to GTEx for DRGX Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x22.5), Brain - Frontal Cortex (BA9) (x6.7), and Brain - Cortex (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of DRGX Gene:

DRGX

SOURCE GeneReport for Unigene cluster for DRGX Gene:

Hs.534530
genes like me logo Genes that share expression patterns with DRGX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DRGX Gene

Orthologs for DRGX Gene

This gene was present in the common ancestor of animals.

Orthologs for DRGX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRGX 34 35
  • 99.08 (n)
rat
(Rattus norvegicus)
Mammalia Drgx 34
  • 89.35 (n)
cow
(Bos Taurus)
Mammalia DRGX 34 35
  • 89.1 (n)
oppossum
(Monodelphis domestica)
Mammalia DRGX 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRGX 34 35
  • 86.95 (n)
mouse
(Mus musculus)
Mammalia Prrxl1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRGX 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRG11 35
  • 84 (a)
OneToOne
DRGX 34
  • 76.79 (n)
lizard
(Anolis carolinensis)
Reptilia DRGX 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drgx 34
  • 69.11 (n)
zebrafish
(Danio rerio)
Actinopterygii drgx 34 35
  • 72.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34340 35
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea alr-1 35
  • 20 (a)
ManyToMany
Species where no ortholog for DRGX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRGX Gene

ENSEMBL:
Gene Tree for DRGX (if available)
TreeFam:
Gene Tree for DRGX (if available)

Paralogs for DRGX Gene

Paralogs for DRGX Gene

(9) SIMAP similar genes for DRGX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DRGX: view

Variants for DRGX Gene

Sequence variations from dbSNP and Humsavar for DRGX Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10581304 -- 49,388,919(+) GCCTG(-/AAC)AACAA intron-variant
rs10857480 -- 49,383,051(+) GCAGG(A/G)CTGAC intron-variant
rs10857481 -- 49,383,693(+) CTCTC(A/G)TGAAT intron-variant
rs10857482 -- 49,387,884(+) CAGAT(C/T)CACAG intron-variant
rs11101115 -- 49,371,035(+) AGGAA(C/G)TACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRGX Gene

Variant ID Type Subtype PubMed ID
nsv1042677 CNV loss 25217958
nsv526843 CNV loss 19592680

Variation tolerance for DRGX Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRGX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRGX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRGX Gene

Disorders for DRGX Gene

Relevant External Links for DRGX

Genetic Association Database (GAD)
DRGX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DRGX

No disorders were found for DRGX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DRGX Gene

Publications for DRGX Gene

  1. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S. … Arnett D.K. (Pharmacogenet. Genomics 2012) 3 46 64
  2. Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets. (PMID: 7496632) Saito T. … Anderson D.J. (Mol. Cell. Neurosci. 1995) 2 3 64
  3. Genome-wide association analysis of Sasang constitution in the Korean population. (PMID: 22394158) Kim B.Y. … Kim J.Y. (J Altern Complement Med 2012) 3 64
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64

Products for DRGX Gene

Sources for DRGX Gene

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