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DRGX Gene

protein-coding   GIFtS: 38
GCID: GC10M050573

Dorsal Root Ganglia Homeobox

(Previous name: paired related homeobox-like 1)
(Previous symbol: PRRXL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dorsal Root Ganglia Homeobox1 2     DRG112 5
PRRXL11 2 3     Dorsal Root Ganglia Homeobox Protein2
Paired Related Homeobox-Like 11 2     Paired-Related Homeobox Protein-Like 13
Paired-Like Homeodomain Trancription Factor DRG111 2     

External Ids:    HGNC: 215361   Entrez Gene: 6441682   Ensembl: ENSG000001656067   OMIM: 6067015   UniProtKB: A6NNA53   

Export aliases for DRGX gene to outside databases

Previous GC identifers: GC10M050243 GC10M044838


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DRGX Gene:
DRGX (dorsal root ganglia homeobox) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ALX1.

UniProtKB/Swiss-Prot: DRGX_HUMAN, A6NNA5
Function: Transcription factor required for the formation of correct projections from nociceptive sensory neurons
to the dorsal horn of the spinal cord and normal perception of pain (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the DRGX gene promoter:
         FOXD3   AP-2gamma   GATA-2   IRF-2   S8   Chx10   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DRGX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DRGX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.23

DRGX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRGX gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M050573:  view genomic region     (about GC identifiers)

Start:
50,572,237 bp from pter      End:
50,603,497 bp from pter
Size:
31,261 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DRGX_HUMAN, A6NNA5 (See protein sequence)
Recommended Name: Dorsal root ganglia homeobox protein  
Size: 263 amino acids; 28672 Da
Subunit: Interacts with RGMB (By similarity)

Explore the universe of human proteins at neXtProt for DRGX: NX_A6NNA5

Explore proteomics data for DRGX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DRGX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001263380.1  
    ENSEMBL proteins: 
     ENSP00000363254   ENSP00000401653  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRD: Homeoboxes / PRD class

    4 InterPro protein domains:
     IPR003654 OAR_dom
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry A6NNA5

    ProtoNet protein and cluster: A6NNA5

    UniProtKB/Swiss-Prot: DRGX_HUMAN, A6NNA5
    Similarity: Belongs to the paired homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with DRGX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRGX_HUMAN, A6NNA5
    Function: Transcription factor required for the formation of correct projections from nociceptive sensory neurons
    to the dorsal horn of the spinal cord and normal perception of pain (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with DRGX           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DRGX_HUMAN, A6NNA5: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with DRGX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DRGX: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DRGX

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for DRGX (ENSP000004016534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK2ENSP000003720234STRING: ENSP00000372023
    --ENSP000003425894STRING: ENSP00000342589
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration ----
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development IEA--
    GO:0007399nervous system development ----

    Find genes that share ontologies with DRGX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DRGX



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DRGX gene (2 alternative transcripts): 
    NM_001080520.1  NM_001276451.1  

    Unigene Cluster for DRGX:

    Dorsal root ganglia homeobox
    Hs.534530  [show with all ESTs]
    Unigene Representative Sequence: NM_001276451
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374139(uc021pqd.1) ENST00000434016(uc010qgq.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat DRGX

    3 DOTS entries:

    DT.121265749  DT.121265751  DT.121265752 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DRGX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGCCCGCG
    DRGX Expression
    About this image

    DRGX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DRGX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534530
        Pathway & Disease-focused RT2 Profiler PCR Array including DRGX: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRGX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DRGX gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DRGX1 dorsal root ganglia homeobox 76.79(n)
    85.77(a)
      771373  XM_001234655.3  XP_001234656.2 
    lizard
    (Anolis carolinensis)
    Reptilia DRGX6
    dorsal root ganglia homeobox
    77(a)
    1 ↔ 1
    GL343297.1(828832-894394)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia drgx1 dorsal root ganglia homeobox 69.11(n)
    76.06(a)
      100493837  XM_002939741.2  XP_002939787.1 
    zebrafish
    (Danio rerio)
    Actinopterygii drgx1 dorsal root ganglia homeobox 72.8(n)
    83.26(a)
      560399  NM_001037105.1  NP_001032182.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG343406
    --
    17(a)
    1 ↔ 1
    2L(3662745-3691737)
    worm
    (Caenorhabditis elegans)
    Secernentea alr-16
    Protein ALR-1 (alr-1) mRNA, complete cds
    20(a)
    many ↔ many
    X(11121944-11125615) WBGene00044330
            Species with no ortholog for DRGX

    ENSEMBL Gene Tree for DRGX (if available)
    TreeFam Gene Tree for DRGX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DRGX gene
    ALX12  PHOX2B2  ARX2  RAX2  SHOX22  PRRX12  PHOX2A2  ALX42  
    ISX2  RAX22  ALX32  SHOX2  OTP2  PRRX22  
    9 SIMAP similar genes for DRGX using alignment to 2 protein entries:     DRGX_HUMAN (see all proteins):
    CDX1    PRRX1    HOPX    DUX2    PHOX2B    ALX4
    PHOX2A    RAX2    ARX

    Find genes that share paralogs with DRGX           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DRGX (see all 696)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs170099561,2
    C,F,H--50573668(+) CTGCTC/TATCTT 1 -- ds50018Minor allele frequency- T:0.05NA NS EA WA 680
    rs771370691,2
    F--50573701(+) TTGGGG/ATTCCA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1483666331,2
    --50573716(+) TTCCCC/TAGTTC 1 -- ds50010--------
    rs1915054571,2
    C--50573808(+) TCAAAA/GGCAGC 1 -- ds50010--------
    rs1415463571,2
    --50573861(+) CCCTCC/TGAGAC 1 -- ds50010--------
    rs782750651,2
    C,F--50573935(+) CCATCG/AGGATC 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs802743571,2
    C,F--50573968(+) ACACTG/ACCGCA 1 -- ds50011Minor allele frequency- A:0.12WA 118
    rs170099571,2
    C,F,H--50573994(+) AGGGAC/TGCTCC 1 -- ds5001 ese38Minor allele frequency- T:0.05NA NS EA WA 678
    rs1157226931,2
    F--50574086(+) TTTGGA/GGAGTT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1508718581,2
    --50574097(+) TTCTGC/TAGGGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DRGX (50572237 - 50603497 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DRGX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526843CNV Loss19592680
    nsv895365CNV Loss21882294
    nsv895377CNV Gain21882294
    nsv895369CNV Gain21882294
    nsv895375CNV Gain21882294
    nsv7203OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606701    OMIM disorders: --


    Find genes that share disorders with DRGX           About GenesLikeMe

    Genetic Association Database (GAD): DRGX

    Export disorders for DRGX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DRGX gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DRGX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PubMed id 22228203)1, 4 Aslibekyan S....Arnett D.K. (Pharmacogenet. Genomics 2012)
    2. Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets. (PubMed id 7496632)1, 3 Saito T....Anderson D.J. (Mol. Cell. Neurosci. 1995)
    3. Genome-wide association analysis of Sasang constitution in the Korean population. (PubMed id 22394158)1 Kim B.Y....Kim J.Y. (J Altern Complement Med 2012)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 644168 HGNC: 21536 Ensembl:ENSG00000165606 euGenes: HUgn644168 ECgene: DRGX
    H-InvDB: DRGX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DRGX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DRGX gene:
    Search GeneIP for patents involving DRGX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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      eBioscience FlowRNA Probe Sets
           
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