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Aliases for DRGX Gene

Aliases for DRGX Gene

  • Dorsal Root Ganglia Homeobox 2 3
  • Paired-Like Homeodomain Trancription Factor DRG11 2 3
  • Paired Related Homeobox-Like 1 2 3
  • PRRXL1 3 4
  • DRG11 3 6
  • Paired-Related Homeobox Protein-Like 1 4
  • Dorsal Root Ganglia Homeobox Protein 3

External Ids for DRGX Gene

Previous Symbols for DRGX Gene

  • PRRXL1

Summaries for DRGX Gene

GeneCards Summary for DRGX Gene

DRGX (Dorsal Root Ganglia Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is PHOX2B.

UniProtKB/Swiss-Prot for DRGX Gene

  • Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRGX Gene

Genomics for DRGX Gene

Genomic Location for DRGX Gene

Start:
49,364,181 bp from pter
End:
49,396,016 bp from pter
Size:
31,836 bases
Orientation:
Minus strand

Genomic View for DRGX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRGX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRGX Gene

Regulatory Elements for DRGX Gene

Proteins for DRGX Gene

  • Protein details for DRGX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNA5-DRGX_HUMAN
    Recommended name:
    Dorsal root ganglia homeobox protein
    Protein Accession:
    A6NNA5
    Secondary Accessions:

    Protein attributes for DRGX Gene

    Size:
    263 amino acids
    Molecular mass:
    28672 Da
    Quaternary structure:
    • Interacts with RGMB.

neXtProt entry for DRGX Gene

Proteomics data for DRGX Gene at MOPED

Post-translational modifications for DRGX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DRGX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRGX Gene

Domains for DRGX Gene

Gene Families for DRGX Gene

HGNC:
  • PRD :Homeoboxes / PRD class

Protein Domains for DRGX Gene

UniProtKB/Swiss-Prot:

DRGX_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • A6NNA5
Family:
  • Belongs to the paired homeobox family.:
    • A6NNA5
genes like me logo Genes that share domains with DRGX: view

Function for DRGX Gene

Molecular function for DRGX Gene

UniProtKB/Swiss-Prot Function: Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.

Gene Ontology (GO) - Molecular Function for DRGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DRGX: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DRGX Gene

Localization for DRGX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRGX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRGX Gene COMPARTMENTS Subcellular localization image for DRGX gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DRGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DRGX: view

Pathways for DRGX Gene

SuperPathways for DRGX Gene

No Data Available

Interacting Proteins for DRGX Gene

Gene Ontology (GO) - Biological Process for DRGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development --
GO:0007409 axonogenesis --
genes like me logo Genes that share ontologies with DRGX: view

No data available for Pathways by source for DRGX Gene

Transcripts for DRGX Gene

mRNA/cDNA for DRGX Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DRGX Gene

Dorsal root ganglia homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DRGX Gene

No ASD Table

Relevant External Links for DRGX Gene

GeneLoc Exon Structure for
DRGX
ECgene alternative splicing isoforms for
DRGX

Expression for DRGX Gene

mRNA expression in normal human tissues for DRGX Gene

mRNA differential expression in normal tissues according to GTEx for DRGX Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (22.5), Brain - Frontal Cortex (BA9) (6.7), and Brain - Cortex (6.1).

SOURCE GeneReport for Unigene cluster for DRGX Gene Hs.534530

genes like me logo Genes that share expressions with DRGX: view

Orthologs for DRGX Gene

This gene was present in the common ancestor of animals.

Orthologs for DRGX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRGX 36
  • 99.08 (n)
  • 99.21 (a)
DRGX 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DRGX 36
  • 89.1 (n)
  • 95.82 (a)
DRGX 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRGX 36
  • 86.95 (n)
  • 94.3 (a)
DRGX 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prrxl1 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRGX 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRGX 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drgx 36
  • 89.35 (n)
  • 95.06 (a)
chicken
(Gallus gallus)
Aves DRG11 37
  • 84 (a)
OneToOne
DRGX 36
  • 76.79 (n)
  • 85.77 (a)
lizard
(Anolis carolinensis)
Reptilia DRGX 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drgx 36
  • 69.11 (n)
  • 76.06 (a)
zebrafish
(Danio rerio)
Actinopterygii drgx 36
  • 72.8 (n)
  • 83.26 (a)
drgx 37
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34340 37
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea alr-1 37
  • 20 (a)
ManyToMany
Species with no ortholog for DRGX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRGX Gene

ENSEMBL:
Gene Tree for DRGX (if available)
TreeFam:
Gene Tree for DRGX (if available)

Paralogs for DRGX Gene

Paralogs for DRGX Gene

Selected SIMAP similar genes for DRGX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DRGX: view

Variants for DRGX Gene

Sequence variations from dbSNP and Humsavar for DRGX Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs877517 -- 49,367,752(-) GGGAC(A/G)CAAGT intron-variant
rs912467 -- 49,386,322(+) AGCAC(G/T)GGACA intron-variant
rs912469 -- 49,370,051(-) CCTGC(C/T)CCTCT intron-variant
rs912471 -- 49,381,697(+) TGGGA(A/G)CCCTG intron-variant
rs1570645 -- 49,384,617(+) ACAGA(C/T)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRGX Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895375 CNV Gain 21882294
nsv526843 CNV Loss 19592680
nsv895377 CNV Gain 21882294

Relevant External Links for DRGX Gene

HapMap Linkage Disequilibrium report
DRGX

Disorders for DRGX Gene

Relevant External Links for DRGX

Genetic Association Database (GAD)
DRGX
genes like me logo Genes that share disorders with DRGX: view

No data available for UniProtKB/Swiss-Prot for DRGX Gene

Publications for DRGX Gene

  1. Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets. (PMID: 7496632) Saito T. … Anderson D.J. (Mol. Cell. Neurosci. 1995) 2 3
  2. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S. … Arnett D.K. (Pharmacogenet. Genomics 2012) 3 49
  3. Genome-wide association analysis of Sasang constitution in the Korean population. (PMID: 22394158) Kim B.Y. … Kim J.Y. (J Altern Complement Med 2012) 3
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4

Products for DRGX Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DRGX
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DRGX
    • Block miRNA regulation of DRGX using miScript Target Protectors

    Sources for DRGX Gene

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