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DRG2 Gene

protein-coding   GIFtS: 62
GCID: GC17P017992

Developmentally Regulated GTP Binding Protein 2

(Previous name: developmentally regulated GTP-binding protein 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Developmentally Regulated GTP Binding Protein 21 2
Developmentally Regulated GTP-Binding Protein 21
Developmentally-Regulated GTP-Binding Protein 22
DRG-23

External Ids:    HGNC: 30301   Entrez Gene: 18192   Ensembl: ENSG000001085917   OMIM: 6029865   UniProtKB: P550393   

Export aliases for DRG2 gene to outside databases

Previous GC identifers: GC17P018236 GC17P019363 GC17P017934 GC17P018191 GC17P017932 GC17P017744


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DRG2 Gene:
This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation.
Read-through transcripts containing this gene and a downstream gene have been identified, but they are not
thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome
17. (provided by RefSeq, Jan 2012)

GeneCards Summary for DRG2 Gene:
DRG2 (developmentally regulated GTP binding protein 2) is a protein-coding gene. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot: DRG2_HUMAN, P55039
Function: May play a role in cell proliferation, differentiation and death

Gene Wiki entry for DRG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DRG2 gene promoter:
         HNF-3beta   POU2F1   POU2F1b   POU2F1a   HNF-1   POU2F1c   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRG2 promoter sequence
   Search Chromatin IP Primers for DRG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DRG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p13-p12

DRG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRG2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P017992:  view genomic region     (about GC identifiers)

Start:
17,991,200 bp from pter      End:
18,011,292 bp from pter
Size:
20,093 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DRG2_HUMAN, P55039 (See protein sequence)
Recommended Name: Developmentally-regulated GTP-binding protein 2  
Size: 364 amino acids; 40746 Da
Subunit: Interacts with RWDD1 (By similarity)
Secondary accessions: B2R8G5 Q53Y50 Q9BWB2

Explore the universe of human proteins at neXtProt for DRG2: NX_P55039

Explore proteomics data for DRG2 at MOPED

Post-translational modifications: 

  • Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1 (By similarity)1
  • Ubiquitination2 at Lys127, Lys161, Lys341
  • Modification sites at PhosphoSitePlus

  • See DRG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001379.1  
    ENSEMBL proteins: 
     ENSP00000225729   ENSP00000462978   ENSP00000379076   ENSP00000464004   ENSP00000464076  
     ENSP00000463747   ENSP00000463268   ENSP00000463522   ENSP00000464244   ENSP00000463436  
     ENSP00000462060   ENSP00000463256  

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    Novus Biologicals DRG2 Protein
    Novus Biologicals DRG2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DRG2

     
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    antibodies-online proteins for DRG2 (5 products) 

     
    antibodies-online peptides for DRG2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR027417 P-loop_NTPase
     IPR005225 Small_GTP-bd_dom
     IPR012676 TGS-like
     IPR006073 GTP_binding_domain
     IPR004095 TGS

    Graphical View of Domain Structure for InterPro Entry P55039

    ProtoNet protein and cluster: P55039

    2 Blocks protein domains:
    IPB002917 GTP-binding protein
    IPB006073 GTP1/OBG GTP-binding protein family signature


    UniProtKB/Swiss-Prot: DRG2_HUMAN, P55039
    Similarity: Belongs to the GTP1/OBG family
    Similarity: Contains 1 G (guanine nucleotide-binding) domain


    Find genes that share domains with DRG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRG2_HUMAN, P55039
    Function: May play a role in cell proliferation, differentiation and death

         Genatlas biochemistry entry for DRG2:
    developmentally regulated GTP-binding protein,41kDa,expressed in normal but not virally transformed fibroblasts

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
    GO:0015093ferrous iron transmembrane transporter activity ----
         
    Find genes that share ontologies with DRG2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for DRG2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased homologous recombina 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Drg2):
     behavior/neurological  growth/size/body  limbs/digits/tail 

    Find genes that share phenotypes with DRG2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DRG2

    miRNA
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    miRTarBase miRNAs that target DRG2:
    hsa-mir-124-3p (MIRT022334), hsa-mir-193b-3p (MIRT041434), hsa-let-7b-5p (MIRT032283), hsa-mir-616-5p (MIRT039603)

    Block miRNA regulation of human, mouse, rat DRG2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate DRG2:
    hsa-miR-24-2* hsa-miR-24-1* hsa-miR-205* hsa-miR-1207-5p hsa-miR-3612 hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidDRG2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DRG2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DRG2_HUMAN, P55039: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    peroxisome2
    plasma membrane2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with DRG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DRG2
    Interactions:

        Search GeneGlobe Interaction Network for DRG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DRG2 (P550392, 3 ENSP000002257294) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RWDD1Q9H4462, 3, ENSP000004203574MINT-67842 I2D: score=5 STRING: ENSP00000420357
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=3 STRING: ENSP00000221413
    ATP6V1B2P212813, ENSP000002763904I2D: score=2 STRING: ENSP00000276390
    DHX38Q926203, ENSP000002684824I2D: score=2 STRING: ENSP00000268482
    EEF1A1P681043, ENSP000003300544I2D: score=2 STRING: ENSP00000330054
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS7929244
    GO:0015684ferrous iron transport ----

    Find genes that share ontologies with DRG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DRG2

    1 HMDB Compound for DRG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DRG2 gene: 
    NM_001388.4  

    Unigene Cluster for DRG2:

    Developmentally regulated GTP binding protein 2
    Hs.78582  [show with all ESTs]
    Unigene Representative Sequence: AB209340
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000225729(uc002gsh.1) ENST00000577771 ENST00000496428 ENST00000395726
    ENST00000578173 ENST00000582314 ENST00000579601 ENST00000473213 ENST00000578767
    ENST00000582419 ENST00000580055 ENST00000467099(uc010vxg.1) ENST00000579224
    ENST00000584212 ENST00000577450 ENST00000580929 ENST00000583162 ENST00000583355

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate DRG2:
    hsa-miR-24-2* hsa-miR-24-1* hsa-miR-205* hsa-miR-1207-5p hsa-miR-3612 hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidDRG2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DRG2
    Predesigned siRNA for gene silencing in human, mouse, rat DRG2
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      QuantiFast Probe-based Assays in human, mouse, rat DRG2

    Additional mRNA sequence: 

    AB209340.1 AK095755.1 AK295575.1 AK297569.1 AK313362.1 BC000493.2 BC062572.1 BT006976.1 
    X80754.1 

    16 DOTS entries:

    DT.95125858  DT.415782  DT.91883037  DT.95359910  DT.100809752  DT.99943033  DT.99935550  DT.95125862 
    DT.100809747  DT.120974914  DT.92441378  DT.100724162  DT.100809746  DT.100809748  DT.120974920  DT.120975006 

    Selected AceView cDNA sequences (see all 309):

    CR602137 BM763131 CR610770 CA393006 BQ706376 AA405448 AI656940 AI380161 
    BU553302 CR619498 BI909797 AW015375 BI768080 CA444541 CK823441 CR591061 
    BQ220102 BP374416 BG250562 NM_001388 BF220080 BU734885 BU684802 AW292629 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DRG2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                -     -           -     -           -     -     -           -     -                                         -               
    SP2:                                                  -     -                                                                                   -               
    SP3:                                -     -           -     -           -     -     -                                                                           
    SP4:                                -     -           -     -                 -     -                                                                           
    SP5:                                -     -           -     -                                                                                                   


    ECgene alternative splicing isoforms for DRG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DRG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGAACCA
    DRG2 Expression
    About this image

    DRG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DRG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78582

    UniProtKB/Swiss-Prot: DRG2_HUMAN, P55039
    Tissue specificity: Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen,
    small intestine, lung and Leukocytes

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    QuantiFast Probe-based Assays in human, mouse, rat DRG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DRG2 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Drg21 , 5 developmentally regulated GTP binding protein 21, 5 90.93(n)1
    98.63(a)1
      11 (37.81 cM)5
    134951  NM_021354.11  NP_067329.11 
     604545915 
    chicken
    (Gallus gallus)
    Aves DRG21 developmentally regulated GTP binding protein 2 81.23(n)
    96.98(a)
      416513  NM_001030634.1  NP_001025805.1 
    lizard
    (Anolis carolinensis)
    Reptilia DRG26
    developmentally regulated GTP binding protein 2
    95(a)
    1 ↔ 1
    GL343977.1(15128-31123)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691362 developmentally regulated GTP binding protein 2 79.5(n)    AB104728.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb96a092 Danio rerio clone RK115A3G01 developmentally regulated more 77.79(n)    AY398336.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61951 , 3 GTP binding3
    CG61951
    80(a)3
    73.09(n)1
    80.72(a)1
      423431  NM_142565.31  NP_650822.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C02F5.31 , 3 GTP-binding protein3
    C02F5.31
    74(a)3
    63.83(n)1
    75.55(a)1
      III(8317627-8320389)3
    1761631  NM_066407.51  NP_498808.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RBG2(YGR173W)4
    RBG21
    Protein with a role in translation; forms a complex more4
    RBG21
    57.05(n)1
    59.34(a)1
      7(843854-844960)4
    8530831, 4  NP_011689.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DRG11 DRG1 62.64(n)
    65.11(a)
      838320  NM_101609.3  NP_173190.1 
    rice
    (Oryza sativa)
    Liliopsida Os.72012 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.15(n)    AK105299.1 


    ENSEMBL Gene Tree for DRG2 (if available)
    TreeFam Gene Tree for DRG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DRG2 gene
    6 SIMAP similar genes for DRG2 using alignment to 10 protein entries:     DRG2_HUMAN (see all proteins):
    COX7A2    MTA3    NUSAP1    ZNF738    DRG1    DKFZp434N1827

    Find genes that share paralogs with DRG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DRG2 (see all 448)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901705761,2
    --17742736(+) TCCCTA/TCTTAC 1 -- us2k10--------
    rs1490356851,2
    C--17742746(+) CCCCC-/TGGCCA 1 -- us2k10--------
    rs1420118381,2
    --17989327(+) TAATCA/CTAGCA 1 -- us2k10--------
    rs1181652321,2
    C,F--17989357(+) GAGGAC/ATGCTT 1 -- us2k11Minor allele frequency- A:0.09EA 120
    rs43653461,2
    C--17989373(+) caggaG/Tttcag 1 -- us2k15Minor allele frequency- T:0.42NA CSA WA EA 361
    rs603661171,2
    --17989388(+) AGCCTG/AGGCAA 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1929818881,2
    --17989393(+) GGGCAA/GCATAG 1 -- us2k10--------
    rs2013974381,2
    --17989415(+) TCTAC-/AAAAAA 1 -- us2k10--------
    rs43492031,2
    C,A,H--17989425(+) aaaaaT/Attttt 1 -- us2k13Minor allele frequency- A:0.49NA EA 244
    rs1848676851,2
    --17989426(+) AAAATA/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DRG2 (17991200 - 18011292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DRG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3077n71CNV Loss21882294
    nsv457697CNV Loss19166990
    nsv907769CNV Loss21882294
    nsv155OTHER Inversion15895083
    nsv499114OTHER Inversion21111241

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602986    OMIM disorders: --


    Find genes that share disorders with DRG2           About GenesLikeMe

    Genetic Association Database (GAD): DRG2
    Human Genome Epidemiology (HuGE) Navigator: DRG2 (1 document)

    Export disorders for DRG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DRG2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with DRG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts. (PubMed id 7929244)1, 2, 3 Schenker T.... Trueb B. (J. Biol. Chem. 1994)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13--&gt;p12 by in situ hybridization. (PubMed id 9605870)1, 3 Schenker T. and Trueb B. (Cytogenet. Cell Genet. 1997)
    6. DRG represents a family of two closely related GTP-binding proteins. (PubMed id 10760581)1, 9 Li B. and Trueeb B. (Biochim. Biophys. Acta 2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1819 HGNC: 3030 AceView: DRG2andMYO15A Ensembl:ENSG00000108591 euGenes: HUgn1819
    ECgene: DRG2 H-InvDB: DRG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DRG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DRG2 gene:
    Search GeneIP for patents involving DRG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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