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Aliases for DRG2 Gene

Aliases for DRG2 Gene

  • Developmentally Regulated GTP Binding Protein 2 2 3
  • Developmentally Regulated GTP-Binding Protein 2 2
  • DRG-2 4

External Ids for DRG2 Gene

Previous GeneCards Identifiers for DRG2 Gene

  • GC17P018236
  • GC17P019363
  • GC17P017934
  • GC17P018191
  • GC17P017932
  • GC17P017744

Summaries for DRG2 Gene

Entrez Gene Summary for DRG2 Gene

  • This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]

GeneCards Summary for DRG2 Gene

DRG2 (Developmentally Regulated GTP Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for DRG2 Gene

  • May play a role in cell proliferation, differentiation and death

Gene Wiki entry for DRG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRG2 Gene

Genomics for DRG2 Gene

Regulatory Elements for DRG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DRG2 Gene

18,087,867 bp from pter
18,107,985 bp from pter
20,119 bases
Plus strand

Genomic View for DRG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRG2 Gene

Proteins for DRG2 Gene

  • Protein details for DRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Developmentally-regulated GTP-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R8G5
    • Q53Y50
    • Q9BWB2

    Protein attributes for DRG2 Gene

    364 amino acids
    Molecular mass:
    40746 Da
    Quaternary structure:
    • Interacts with RWDD1.

neXtProt entry for DRG2 Gene

Proteomics data for DRG2 Gene at MOPED

Post-translational modifications for DRG2 Gene

  • Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1.
  • Ubiquitination at Lys127, Lys161, and Lys341
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DRG2 Gene

Domains for DRG2 Gene

Suggested Antigen Peptide Sequences for DRG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P55039
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with DRG2: view

No data available for Gene Families for DRG2 Gene

Function for DRG2 Gene

Molecular function for DRG2 Gene

GENATLAS Biochemistry:
developmentally regulated GTP-binding protein,41kDa,expressed in normal but not virally transformed fibroblasts
UniProtKB/Swiss-Prot Function:
May play a role in cell proliferation, differentiation and death

Gene Ontology (GO) - Molecular Function for DRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
GO:0015093 ferrous iron transmembrane transporter activity --
genes like me logo Genes that share ontologies with DRG2: view
genes like me logo Genes that share phenotypes with DRG2: view

Animal Model Products

miRNA for DRG2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DRG2 Gene

Localization for DRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRG2 Gene


Subcellular locations from

Jensen Localization Image for DRG2 Gene COMPARTMENTS Subcellular localization image for DRG2 gene
Compartment Confidence
cytosol 3
mitochondrion 2
peroxisome 2
plasma membrane 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with DRG2: view

Pathways for DRG2 Gene

SuperPathways for DRG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7929244
GO:0015684 ferrous iron transport --
genes like me logo Genes that share ontologies with DRG2: view

No data available for Pathways by source for DRG2 Gene

Compounds for DRG2 Gene

(1) HMDB Compounds for DRG2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with DRG2: view

Transcripts for DRG2 Gene

Unigene Clusters for DRG2 Gene

Developmentally regulated GTP binding protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRG2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRG2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8: - -

Relevant External Links for DRG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DRG2 Gene

mRNA expression in normal human tissues for DRG2 Gene

Protein differential expression in normal tissues for DRG2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.9) and Salivary gland (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DRG2 Gene

SOURCE GeneReport for Unigene cluster for DRG2 Gene Hs.78582

mRNA Expression by UniProt/SwissProt for DRG2 Gene

Tissue specificity: Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes
genes like me logo Genes that share expressions with DRG2: view

Expression partners for DRG2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DRG2 Gene

Orthologs for DRG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DRG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DRG2 35
  • 91.3 (n)
  • 99.18 (a)
DRG2 36
  • 99 (a)
(Canis familiaris)
Mammalia DRG2 35
  • 92.03 (n)
  • 99.73 (a)
DRG2 36
  • 100 (a)
(Mus musculus)
Mammalia Drg2 35
  • 90.93 (n)
  • 98.63 (a)
Drg2 16
Drg2 36
  • 99 (a)
(Pan troglodytes)
Mammalia DRG2 35
  • 93.59 (n)
  • 93.13 (a)
DRG2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Drg2 35
  • 90.75 (n)
  • 98.63 (a)
(Monodelphis domestica)
Mammalia DRG2 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia DRG2 36
  • 97 (a)
(Gallus gallus)
Aves DRG2 35
  • 81.23 (n)
  • 96.98 (a)
DRG2 36
  • 97 (a)
(Anolis carolinensis)
Reptilia DRG2 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia drg2 35
  • 79.76 (n)
  • 95.6 (a)
Str.7109 35
African clawed frog
(Xenopus laevis)
Amphibia MGC69136 35
(Danio rerio)
Actinopterygii drg2 35
  • 75.92 (n)
  • 91.48 (a)
wufb96a09 35
drg2 36
  • 91 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.773 35
fruit fly
(Drosophila melanogaster)
Insecta CG6195 37
  • 80 (a)
CG6195 35
  • 73.09 (n)
  • 80.72 (a)
CG6195 36
  • 81 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002185 35
  • 72.82 (n)
  • 80.17 (a)
(Caenorhabditis elegans)
Secernentea C02F5.3 37
  • 74 (a)
C02F5.3 35
  • 63.83 (n)
  • 75.55 (a)
C02F5.3 36
  • 75 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL134W 35
  • 61.25 (n)
  • 60.06 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F14993g 35
  • 56.96 (n)
  • 59.34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RBG2 35
  • 57.05 (n)
  • 59.34 (a)
RBG2 36
  • 58 (a)
RBG2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DRG1 35
  • 62.64 (n)
  • 65.11 (a)
(Oryza sativa)
Liliopsida Os.7201 35
Os05g0357600 35
  • 62.27 (n)
  • 65.11 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01183 35
  • 60.6 (n)
  • 60.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtp1 35
  • 60.7 (n)
  • 66.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 73 (a)
Species with no ortholog for DRG2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRG2 Gene

Gene Tree for DRG2 (if available)
Gene Tree for DRG2 (if available)

Paralogs for DRG2 Gene

genes like me logo Genes that share paralogs with DRG2: view

No data available for Paralogs for DRG2 Gene

Variants for DRG2 Gene

Sequence variations from dbSNP and Humsavar for DRG2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs712265 -- 18,105,133(-) CCCCA(C/T)CCCAA intron-variant
rs721669 -- 18,101,759(-) AACCC(C/T)GGTTT intron-variant
rs741783 -- 18,097,007(+) AAGCC(A/G)CTCTA intron-variant
rs854762 -- 18,105,788(+) ATGTG(A/G)GAGGA intron-variant
rs854808 -- 18,103,320(-) ACCTC(A/G)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRG2 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
nsv907769 CNV Loss 21882294
nsv457697 CNV Loss 19166990
dgv3077n71 CNV Loss 21882294

Relevant External Links for DRG2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRG2 Gene

Disorders for DRG2 Gene

Relevant External Links for DRG2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DRG2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DRG2 Gene

Publications for DRG2 Gene

  1. A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts. (PMID: 7929244) Schenker T. … Trueb B. (J. Biol. Chem. 1994) 2 3 4
  2. DRG represents a family of two closely related GTP-binding proteins. (PMID: 10760581) Li B. … Trueeb B. (Biochim. Biophys. Acta 2000) 3 23
  3. Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13-->p12 by in situ hybridization. (PMID: 9605870) Schenker T. … Trueb B. (Cytogenet. Cell Genet. 1997) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DRG2 Gene

Sources for DRG2 Gene

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