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Aliases for DRG2 Gene

Aliases for DRG2 Gene

  • Developmentally Regulated GTP Binding Protein 2 2 3 5
  • Developmentally Regulated GTP-Binding Protein 2 2
  • DRG-2 4

External Ids for DRG2 Gene

Previous GeneCards Identifiers for DRG2 Gene

  • GC17P018236
  • GC17P019363
  • GC17P017934
  • GC17P018191
  • GC17P017932
  • GC17P017992
  • GC17P017744

Summaries for DRG2 Gene

Entrez Gene Summary for DRG2 Gene

  • This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]

GeneCards Summary for DRG2 Gene

DRG2 (Developmentally Regulated GTP Binding Protein 2) is a Protein Coding gene. Diseases associated with DRG2 include Smith-Magenis Syndrome and Potocki-Luspski Syndrome. GO annotations related to this gene include GTP binding and ferrous iron transmembrane transporter activity.

UniProtKB/Swiss-Prot for DRG2 Gene

  • May play a role in cell proliferation, differentiation and death.

Gene Wiki entry for DRG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRG2 Gene

Genomics for DRG2 Gene

Regulatory Elements for DRG2 Gene

Enhancers for DRG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G017913 1.9 FANTOM5 Ensembl ENCODE dbSUPER 39.4 -173.6 -173589 1.6 PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF2 FOS ZNF263 SP3 SP5 DRG2 FOXO3B ENSG00000264885 SMCR8 LOC100419436 RPL13P12 ZNF286B MPRIP-AS1 FAM106A RAI1
GH17G017833 1.9 FANTOM5 ENCODE dbSUPER 25.9 -249.4 -249413 8.9 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ENSG00000264885 DRG2 SMCR8 TOM1L2 FOXO3B MPRIP-AS1 FAM106A RPL13P12 LOC100419436 FLCN
GH17G019052 0.9 dbSUPER 45.4 +965.4 965448 1.5 ZNF493 ZFP64 ZEB1 ZNF138 ZNF354C KLF7 ZNF202 ZNF680 ZNF654 ZBTB11 FOXO3B ENSG00000264885 DRG2 FAM106A ZNF286B ENSG00000273018 SMCR8 TVP23B LINC02094 USP32P2
GH17G018181 1.7 FANTOM5 ENCODE dbSUPER 23.6 +97.2 97213 8.0 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 ZNF286B SMCR8 SMCR5 FOXO3B MYO15A DRG2 LLGL1 ENSG00000264885 MIEF2 FAM106A
GH17G017932 2 FANTOM5 Ensembl ENCODE dbSUPER 17.5 -151.6 -151558 6.7 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ENSG00000197815 TOM1L2 DRG2 SMCR8 FOXO3B ENSG00000265511 RAI1 SREBF1 MYO15A ATPAF2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DRG2 on UCSC Golden Path with GeneCards custom track

Promoters for DRG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092044 233 1401 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3

Genomic Location for DRG2 Gene

18,087,867 bp from pter
18,107,985 bp from pter
20,119 bases
Plus strand

Genomic View for DRG2 Gene

Genes around DRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRG2 Gene

Proteins for DRG2 Gene

  • Protein details for DRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Developmentally-regulated GTP-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R8G5
    • Q53Y50
    • Q9BWB2

    Protein attributes for DRG2 Gene

    364 amino acids
    Molecular mass:
    40746 Da
    Quaternary structure:
    • Interacts with RWDD1.

neXtProt entry for DRG2 Gene

Post-translational modifications for DRG2 Gene

  • Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1.
  • Ubiquitination at Lys127, isoforms=161, and isoforms=341
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DRG2 Gene

Domains & Families for DRG2 Gene

Suggested Antigen Peptide Sequences for DRG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with DRG2: view

No data available for Gene Families for DRG2 Gene

Function for DRG2 Gene

Molecular function for DRG2 Gene

GENATLAS Biochemistry:
developmentally regulated GTP-binding protein,41kDa,expressed in normal but not virally transformed fibroblasts
UniProtKB/Swiss-Prot Function:
May play a role in cell proliferation, differentiation and death.

Gene Ontology (GO) - Molecular Function for DRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with DRG2: view
genes like me logo Genes that share phenotypes with DRG2: view

Animal Models for DRG2 Gene

MGI Knock Outs for DRG2:
  • Drg2 tm1a(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

miRNA for DRG2 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DRG2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRG2 Gene

Localization for DRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRG2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRG2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DRG2: view

Pathways & Interactions for DRG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7929244
genes like me logo Genes that share ontologies with DRG2: view

No data available for Pathways by source and SIGNOR curated interactions for DRG2 Gene

Drugs & Compounds for DRG2 Gene

(1) Drugs for DRG2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DRG2: view

Transcripts for DRG2 Gene

Unigene Clusters for DRG2 Gene

Developmentally regulated GTP binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DRG2

Alternative Splicing Database (ASD) splice patterns (SP) for DRG2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8: - -

Relevant External Links for DRG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DRG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRG2 Gene

Protein differential expression in normal tissues from HIPED for DRG2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.9) and Salivary gland (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DRG2 Gene

Protein tissue co-expression partners for DRG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DRG2 Gene:


SOURCE GeneReport for Unigene cluster for DRG2 Gene:


mRNA Expression by UniProt/SwissProt for DRG2 Gene:

Tissue specificity: Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes.

Evidence on tissue expression from TISSUES for DRG2 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DRG2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRG2 Gene

Orthologs for DRG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DRG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia DRG2 35
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia DRG2 35
  • 97 (a)
(Pan troglodytes)
Mammalia DRG2 34 35
  • 93.59 (n)
(Canis familiaris)
Mammalia DRG2 34 35
  • 92.03 (n)
(Bos Taurus)
Mammalia DRG2 34 35
  • 91.3 (n)
(Mus musculus)
Mammalia Drg2 34 16 35
  • 90.93 (n)
(Rattus norvegicus)
Mammalia Drg2 34
  • 90.75 (n)
(Gallus gallus)
Aves DRG2 34 35
  • 81.23 (n)
(Anolis carolinensis)
Reptilia DRG2 35
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia drg2 34
  • 79.76 (n)
Str.7109 34
African clawed frog
(Xenopus laevis)
Amphibia MGC69136 34
(Danio rerio)
Actinopterygii drg2 34 35
  • 75.92 (n)
wufb96a09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.773 34
fruit fly
(Drosophila melanogaster)
Insecta CG6195 36 34 35
  • 73.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002185 34
  • 72.82 (n)
(Caenorhabditis elegans)
Secernentea C02F5.3 36 34 35
  • 63.83 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL134W 34
  • 61.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RBG2 34 35 37
  • 57.05 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F14993g 34
  • 56.96 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DRG1 34
  • 62.64 (n)
(Oryza sativa)
Liliopsida Os05g0357600 34
  • 62.27 (n)
Os.7201 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtp1 34
  • 60.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01183 34
  • 60.6 (n)
Species where no ortholog for DRG2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRG2 Gene

Gene Tree for DRG2 (if available)
Gene Tree for DRG2 (if available)

Paralogs for DRG2 Gene

genes like me logo Genes that share paralogs with DRG2: view

No data available for Paralogs for DRG2 Gene

Variants for DRG2 Gene

Sequence variations from dbSNP and Humsavar for DRG2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000210526 -- 18,105,177(+) CCCCA(C/G)GGGAG intron-variant
rs1000268454 -- 18,098,855(+) CTGCA(A/C)TGGGC intron-variant
rs1000325226 -- 18,092,717(+) TTATT(C/T)AAATA intron-variant
rs1000395212 -- 18,094,431(+) GGTTT(C/T)TCTGG intron-variant
rs1000706461 -- 18,106,449(+) CCACC(A/G)GTCAC intron-variant, downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DRG2 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER inversion 15895083
nsv457697 CNV loss 19166990
nsv499114 OTHER inversion 21111241
nsv574527 CNV loss 21841781
nsv953839 CNV deletion 24416366

Variation tolerance for DRG2 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRG2 Gene

Disorders for DRG2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DRG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smith-magenis syndrome
  • 17p11.2 microdeletion syndrome
potocki-luspski syndrome
  • potocki-lupski syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DRG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DRG2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DRG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRG2 Gene

Publications for DRG2 Gene

  1. A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts. (PMID: 7929244) Schenker T. … Trueb B. (J. Biol. Chem. 1994) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. DRG represents a family of two closely related GTP-binding proteins. (PMID: 10760581) Li B. … Trueeb B. (Biochim. Biophys. Acta 2000) 3 22 64

Products for DRG2 Gene

Sources for DRG2 Gene

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